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For in vivo assessment, Histamine (0.1\u00a0ml from 1% w\/v) and Formaldehyde (0.1\u00a0ml from 2% v\/v) were used to mediate inflammation. In silico molecular docking and network pharmacology were employed to probe the possible target genes mediating gastroprotective effect of \u03b2-Citronellol at 25, 50, and 100\u00a0mg\/kg, using indomethacin-induced (25\u00a0mg\/kg i.p) gastric ulcer in rats. Moreover, Gastric tissues were evaluated for morphological, histopathological, and bio-chemical analysis of PGE<jats:sub>2,<\/jats:sub> COX-I, COX-II, 5-LOX, eNOS, ICAM-1, oxygen-free radical scavengers (SOD, CAT), and oxidative stress marker (MDA).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>\u03b2<jats:italic>-<\/jats:italic>Citronellol prevented denaturation of proteins and RBCs membrane stabilization with maximum effect observed at 6,400\u00a0\u00b5g\/mL. Citronellol decreased rat\u2019s paw edema. Network pharmacology and docking studies revealed gastro-protective potential of Citronellol possibly mediated through arachidonic acid pathways by targeting COX-I, COX-II, PGE<jats:sub>2<\/jats:sub>, and 5-LOX. Citronellol reduced the ulcer indices, and histopathological changes. Further, \u03b2<jats:italic>-<\/jats:italic>Citronellol (50 and 100\u00a0mg\/kg) increased gastric PGE<jats:sub>2,<\/jats:sub> COX-1, and eNOS; while suppressing COX-2, 5-LOX and ICAM-1. Citronellol markedly enhanced the oxidative balance in isolated rat stomach tissues.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>The anti-inflammatory, anti-oxidant, and gastro-protective effects of \u03b2<jats:italic>-<\/jats:italic>Citronellol against indomethacin-induced gastric ulcer model in rats through mediating COX-I, COX-II, PGE<jats:sub>2,<\/jats:sub> 5-LOX, eNOS, and ICAM-1 inflammatory markers.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Graphical abstract<\/jats:title>\n                \n              <\/jats:sec>","DOI":"10.1007\/s10787-024-01569-x","type":"journal-article","created":{"date-parts":[[2024,9,29]],"date-time":"2024-09-29T05:01:36Z","timestamp":1727586096000},"page":"3761-3784","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["\u03b2-Citronellol: a potential anti-inflammatory and gastro-protective agent-mechanistic insights into its modulatory effects on COX-II, 5-LOX, eNOS, and ICAM-1 pathways through in vitro, in vivo, in silico, and network pharmacology studies"],"prefix":"10.1007","volume":"32","author":[{"given":"Urooj","family":"Iqbal","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdul","family":"Malik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nabeela Tabassum","family":"Sial","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Malik Hassan","family":"Mehmood","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shoaib","family":"Nawaz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9020-874X","authenticated-orcid":false,"given":"Marios","family":"Papadakis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dalia","family":"Fouad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hayam","family":"Ateyya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nermeen N.","family":"Welson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2206-7236","authenticated-orcid":false,"given":"Athanasios","family":"Alexiou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gaber El-Saber","family":"Batiha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,9,29]]},"reference":[{"key":"1569_CR1","doi-asserted-by":"publisher","first-page":"914032","DOI":"10.3389\/fonc.2022.914032","volume":"12","author":"S Ahmed","year":"2022","unstructured":"Ahmed S, Mobashir M, Al-Keridis LA, Alshammari N, Adnan M, Abid M, Hassan MI (2022) A network-guided approach to discover phytochemical-based anticancer therapy: targeting MARK4 for hepatocellular carcinoma. 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