{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T16:34:45Z","timestamp":1792514085886,"version":"4.5.0"},"reference-count":107,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2025,2,16]],"date-time":"2025-02-16T00:00:00Z","timestamp":1739664000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,2,16]],"date-time":"2025-02-16T00:00:00Z","timestamp":1739664000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Inflammopharmacol"],"published-print":{"date-parts":[[2025,3]]},"DOI":"10.1007\/s10787-025-01653-w","type":"journal-article","created":{"date-parts":[[2025,2,16]],"date-time":"2025-02-16T09:36:36Z","timestamp":1739698596000},"page":"959-977","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Implications of nociceptor receptors and immune modulation: emerging therapeutic targets for autoimmune diseases"],"prefix":"10.1007","volume":"33","author":[{"given":"Syeda Asloob","family":"Fatima","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8380-7827","authenticated-orcid":false,"given":"Bushra","family":"Akhtar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali","family":"Sharif","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammad Imran","family":"Khan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammad","family":"Shahid","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fozia","family":"Anjum","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fatma","family":"Hussain","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aisha","family":"Mobashar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maham","family":"Ashraf","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,2,16]]},"reference":[{"key":"1653_CR1","doi-asserted-by":"publisher","first-page":"216","DOI":"10.1002\/ejp.1140","volume":"22","author":"L Arendt-Nielsen","year":"2018","unstructured":"Arendt-Nielsen L, Morlion B, Perrot S, Dahan A, Dickenson A, Kress H, Wells C, Bouhassira D, Drewes AM (2018) Assessment and manifestation of central sensitisation across different chronic pain conditions. Eur J Pain 22:216\u2013241","journal-title":"Eur J Pain"},{"key":"1653_CR2","doi-asserted-by":"publisher","first-page":"433","DOI":"10.1038\/s41577-019-0147-2","volume":"19","author":"P Baral","year":"2019","unstructured":"Baral P, Udit S, Chiu IM (2019) Pain and immunity: implications for host defence. Nat Rev Immunol 19:433\u2013447","journal-title":"Nat Rev Immunol"},{"key":"1653_CR3","doi-asserted-by":"publisher","first-page":"2951","DOI":"10.1096\/fj.12-205765","volume":"26","author":"M Barber\u00e0-Cremades","year":"2012","unstructured":"Barber\u00e0-Cremades M, Baroja-Mazo A, Gomez AI, Machado F, di Virgilio F, Pelegr\u00edn P (2012) P2X7 receptor-stimulation causes fever via PGE2 and IL-1\u03b2 release. FASEB J 26:2951\u20132962","journal-title":"FASEB J"},{"key":"1653_CR4","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1016\/j.cell.2009.09.028","volume":"139","author":"AI Basbaum","year":"2009","unstructured":"Basbaum AI, Bautista DM, Scherrer G, Julius D (2009) Cellular and molecular mechanisms of pain. Cell 139:267\u2013284","journal-title":"Cell"},{"key":"1653_CR5","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1146\/annurev-physiol-030212-183811","volume":"75","author":"DM Bautista","year":"2013","unstructured":"Bautista DM, Pellegrino M, Tsunozaki M (2013) TRPA1: a gatekeeper for inflammation. Annu Rev Physiol 75:181\u2013200","journal-title":"Annu Rev Physiol"},{"key":"1653_CR6","doi-asserted-by":"publisher","first-page":"2219","DOI":"10.1111\/bph.13957","volume":"175","author":"LP Bernier","year":"2018","unstructured":"Bernier LP, Ase AR, S\u00e9gu\u00e9la P (2018) P2X receptor channels in chronic pain pathways. Br J Pharmacol 175:2219\u20132230","journal-title":"Br J Pharmacol"},{"key":"1653_CR7","doi-asserted-by":"publisher","first-page":"479","DOI":"10.4161\/19336950.2014.991640","volume":"8","author":"S Bertin","year":"2014","unstructured":"Bertin S, de Jong PR, Jefferies WA, Raz E (2014) Novel immune function for the TRPV1 channel in T lymphocytes. Channels 8:479\u2013480","journal-title":"Channels"},{"key":"1653_CR8","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s11926-016-0581-0","volume":"18","author":"SD Boyden","year":"2016","unstructured":"Boyden SD, Hossain IN, Wohlfahrt A, Lee YC (2016) Non-inflammatory causes of pain in patients with rheumatoid arthritis. Curr Rheumatol Rep 18:1\u20138","journal-title":"Curr Rheumatol Rep"},{"key":"1653_CR9","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1016\/bs.apha.2015.09.001","volume":"75","author":"G Burnstock","year":"2016","unstructured":"Burnstock G (2016) Purinergic mechanisms and pain. Adv Pharmacol 75:91\u2013137","journal-title":"Adv Pharmacol"},{"key":"1653_CR10","first-page":"188","volume":"20","author":"I Calik","year":"2020","unstructured":"Calik I, Calik M, Sarikaya B, Ozercan IH, Arslan R, Artas G, Dagli AF (2020) P2X7 receptor as an independent prognostic indicator in gastric cancer. Bosn J Basic Med Sci 20:188","journal-title":"Bosn J Basic Med Sci"},{"key":"1653_CR11","doi-asserted-by":"publisher","first-page":"205873841983838","DOI":"10.1177\/2058738419838383","volume":"33","author":"E Cavalli","year":"2019","unstructured":"Cavalli E, Mammana S, Nicoletti F, Bramanti P, Mazzon E (2019) The neuropathic pain: An overview of the current treatment and future therapeutic approaches. Int J Immunopathol Pharmacol 33:2058738419838383","journal-title":"Int J Immunopathol Pharmacol"},{"key":"1653_CR12","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2023.117498","volume":"321","author":"R Chalotra","year":"2024","unstructured":"Chalotra R, Dhanawat M, Chauhan S, Mujwar S, Gupta S (2024) Evaluation of Iris Kashmiriana Baker plant extracts against nociception and rheumatoid arthritis in experimental rats: a concept proof by In-silico model. J Ethnopharmacol 321:117498","journal-title":"J Ethnopharmacol"},{"key":"1653_CR13","volume-title":"Neuroimmune interactions in pain: mechanisms and therapeutics","author":"O Chen","year":"2023","unstructured":"Chen O, Rahman S, Olexa M, Ji J, Huh Y, Ji RR (2023) Neuroimmune interactions in acute and chronic itch. Neuroimmune interactions in pain: mechanisms and therapeutics. Springer"},{"key":"1653_CR14","doi-asserted-by":"publisher","first-page":"1063","DOI":"10.1038\/nn.3144","volume":"15","author":"IM Chiu","year":"2012","unstructured":"Chiu IM, von Hehn CA, Woolf CJ (2012) Neurogenic inflammation and the peripheral nervous system in host defense and immunopathology. Nat Neurosci 15:1063\u20131067","journal-title":"Nat Neurosci"},{"issue":"1\u20132","key":"1653_CR15","doi-asserted-by":"publisher","first-page":"132","DOI":"10.1016\/j.pain.2007.06.006","volume":"132","author":"BA Chizh","year":"2007","unstructured":"Chizh BA, O\u2019Donnell MB, Napolitano A, Wang J, Brooke AC, Aylott MC, Bullman JN, Gray EJ, Lai RY, Williams PM, Appleby JM (2007) The effects of the TRPV1 antagonist SB-705498 on TRPV1 receptor-mediated activity and inflammatory hyperalgesia in humans. Pain 132(1\u20132):132\u2013141","journal-title":"Pain"},{"key":"1653_CR16","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0138592","volume":"10","author":"JH Choi","year":"2015","unstructured":"Choi JH, Lee MJ, Jang M, Kim E-J, Shim I, Kim H-J, Lee S, Lee SW, Kim YO, Cho I-H (2015) An oriental medicine, Hyungbangpaedok-San attenuates motor paralysis in an experimental model of multiple sclerosis by regulating the T cell response. PLoS ONE 10:e0138592","journal-title":"PLoS ONE"},{"key":"1653_CR17","doi-asserted-by":"publisher","first-page":"723","DOI":"10.1124\/mol.112.083279","volume":"83","author":"COX, B. M.","year":"2013","unstructured":"COX, B. M. (2013) Recent developments in the study of opioid receptors. Mol Pharmacol 83:723\u2013728","journal-title":"Mol Pharmacol"},{"key":"1653_CR18","doi-asserted-by":"publisher","first-page":"668","DOI":"10.55563\/clinexprheumatol\/e7ayu8","volume":"39","author":"N Crispino","year":"2021","unstructured":"Crispino N, Ciccia F (2021) JAK\/STAT pathway and nociceptive cytokine signalling in rheumatoid arthritis and psoriatic arthritis. Clin Exp Rheumatol 39:668\u2013675","journal-title":"Clin Exp Rheumatol"},{"key":"1653_CR19","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1007\/s12035-014-8790-x","volume":"51","author":"MD da Silva","year":"2015","unstructured":"da Silva MD, Bobinski F, Sato KL, Kolker SJ, Sluka KA, Santos AR (2015) IL-10 cytokine released from M2 macrophages is crucial for analgesic and anti-inflammatory effects of acupuncture in a model of inflammatory muscle pain. Mol Neurobiol 51:19\u201331","journal-title":"Mol Neurobiol"},{"key":"1653_CR20","doi-asserted-by":"publisher","first-page":"1511","DOI":"10.3390\/cells12111511","volume":"12","author":"DP Dalenogare","year":"2023","unstructured":"Dalenogare DP, Monteiro S, de Ara\u00fajo D, Landini L, Titiz M, de Siena G, de Logu F, Geppetti P, Nassini R, Trevisan G (2023) Neuropathic-like nociception and spinal cord neuroinflammation are dependent on the TRPA1 channel in multiple sclerosis models in mice. Cells 12:1511","journal-title":"Cells"},{"key":"1653_CR21","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1111\/imr.12757","volume":"289","author":"BA David","year":"2019","unstructured":"David BA, Kubes P (2019) Exploring the complex role of chemokines and chemoattractants in vivo on leukocyte dynamics. Immunol Rev 289:9\u201330","journal-title":"Immunol Rev"},{"issue":"3","key":"1653_CR22","first-page":"383","volume":"13","author":"CL Deal","year":"1991","unstructured":"Deal CL, Schnitzer TJ, Lipstein E, Seibold JR, Stevens RM, Levy MD, Albert D, Renold F (1991) Treatment of arthritis with topical capsaicin: a double-blind trial. Clin Ther 13(3):383\u2013395","journal-title":"Clin Ther"},{"key":"1653_CR23","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0123810","volume":"10","author":"A Deiteren","year":"2015","unstructured":"Deiteren A, van der Linden L, de Wit A, Ceuleers H, Buckinx R, Timmermans J-P, Moreels TG, Pelckmans PA, de Man JG, de Winter BY (2015) P2X3 receptors mediate visceral hypersensitivity during acute chemically-induced colitis and in the post-inflammatory phase via different mechanisms of sensitization. PLoS ONE 10:e0123810","journal-title":"PLoS ONE"},{"key":"1653_CR24","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1016\/j.immuni.2017.06.020","volume":"47","author":"F di Virgilio","year":"2017","unstructured":"di Virgilio F, dal Ben D, Sarti AC, Giuliani AL, Falzoni S (2017) The P2X7 receptor in infection and inflammation. Immunity 47:15\u201331","journal-title":"Immunity"},{"key":"1653_CR25","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1111\/ene.13819","volume":"26","author":"R Dobson","year":"2019","unstructured":"Dobson R, Giovannoni G (2019) Multiple sclerosis\u2013a review. Eur J Neurol 26:27\u201340","journal-title":"Eur J Neurol"},{"key":"1653_CR26","first-page":"592","volume":"7","author":"MJ Docherty","year":"2011","unstructured":"Docherty MJ, Jones RCW III, Wallace MS (2011) Managing pain in inflammatory bowel disease. Gastroenterol Hepatol 7:592","journal-title":"Gastroenterol Hepatol"},{"key":"1653_CR27","doi-asserted-by":"publisher","first-page":"1881","DOI":"10.3390\/cells10081881","volume":"10","author":"R Domoto","year":"2021","unstructured":"Domoto R, Sekiguchi F, Tsubota M, Kawabata A (2021) Macrophage as a peripheral pain regulator. Cells 10:1881","journal-title":"Cells"},{"key":"1653_CR28","doi-asserted-by":"publisher","first-page":"409","DOI":"10.1124\/jpet.106.105890","volume":"324","author":"D Donnelly-Roberts","year":"2008","unstructured":"Donnelly-Roberts D, McGaraughty S, Shieh C-C, Honore P, Jarvis MF (2008) Painful purinergic receptors. J Pharmacol Exp Ther 324:409\u2013415","journal-title":"J Pharmacol Exp Ther"},{"key":"1653_CR29","doi-asserted-by":"publisher","first-page":"3760","DOI":"10.1172\/JCI42843","volume":"120","author":"AE Dubin","year":"2010","unstructured":"Dubin AE, Patapoutian A (2010) Nociceptors: the sensors of the pain pathway. J Clin Investig 120:3760\u20133772","journal-title":"J Clin Investig"},{"key":"1653_CR30","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1146\/annurev-pharmtox-061008-103038","volume":"49","author":"DJ Dupr\u00e9","year":"2009","unstructured":"Dupr\u00e9 DJ, Robitaille M, Rebois RV, H\u00e9bert TE (2009) The role of G\u03b2\u03b3 subunits in the organization, assembly, and function of GPCR signaling complexes. Annu Rev Pharmacol Toxicol 49:31\u201356","journal-title":"Annu Rev Pharmacol Toxicol"},{"key":"1653_CR31","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/ar1407","volume":"6","author":"RA Eisenberg","year":"2004","unstructured":"Eisenberg RA, Khan S, Stansberry J, Tsai D, Kolasinski S, Rieder E, Kotzin B, Looney RJ, Strieber C, Albert D (2004) An open-label safety and efficacy study of an anti-CD20 antibody (rituximab, Rituxan) for anti-B-cell therapy in the treatment of systemic lupus erythematosus. Arthritis Res Ther 6:1\u201341","journal-title":"Arthritis Res Ther"},{"key":"1653_CR32","doi-asserted-by":"publisher","first-page":"1599","DOI":"10.1097\/j.pain.0000000000000492","volume":"157","author":"NB Finnerup","year":"2016","unstructured":"Finnerup NB, Haroutounian S, Kamerman P, Baron R, Bennett DL, Bouhassira D, Cruccu G, Freeman R, Hansson P, Nurmikko T (2016) Neuropathic pain: an updated grading system for research and clinical practice. Pain 157:1599\u20131606","journal-title":"Pain"},{"key":"1653_CR33","volume-title":"Pain care essentials and innovations","author":"CJ Fisher","year":"2021","unstructured":"Fisher CJ, Yaksh TL, Bruno K, Eddinger KA (2021) Basic science of pain. Pain care essentials and innovations. Elsevier"},{"key":"1653_CR34","doi-asserted-by":"publisher","first-page":"160","DOI":"10.1016\/j.fitote.2014.03.018","volume":"95","author":"M Galuppo","year":"2014","unstructured":"Galuppo M, Giacoppo S, de Nicola GR, Iori R, Navarra M, Lombardo GE, Bramanti P, Mazzon E (2014) Antiinflammatory activity of glucomoringin isothiocyanate in a mouse model of experimental autoimmune encephalomyelitis. Fitoterapia 95:160\u2013174","journal-title":"Fitoterapia"},{"key":"1653_CR35","doi-asserted-by":"publisher","first-page":"E6808","DOI":"10.1073\/pnas.1501372112","volume":"112","author":"N Ghasemlou","year":"2015","unstructured":"Ghasemlou N, Chiu IM, Julien J-P, Woolf CJ (2015) CD11b+ Ly6G\u2212 myeloid cells mediate mechanical inflammatory pain hypersensitivity. Proc Natl Acad Sci 112:E6808\u2013E6817","journal-title":"Proc Natl Acad Sci"},{"key":"1653_CR36","doi-asserted-by":"publisher","first-page":"174480691772431","DOI":"10.1177\/1744806917724318","volume":"13","author":"S Giacoppo","year":"2017","unstructured":"Giacoppo S, Iori R, Bramanti P, Mazzon E (2017) Topical moringin cream relieves neuropathic pain by suppression of inflammatory pathway and voltage-gated ion channels in murine model of multiple sclerosis. Mol Pain 13:1744806917724318","journal-title":"Mol Pain"},{"key":"1653_CR37","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1007\/s10571-020-00832-3","volume":"41","author":"EC Gon\u00e7alves","year":"2021","unstructured":"Gon\u00e7alves EC, Vieira G, Gon\u00e7alves TR, Sim\u00f5es RR, Brusco I, Oliveira SM, Calixto JB, Cola M, Santos AR, Dutra RC (2021) Bradykinin receptors play a critical role in the chronic post-ischaemia pain model. Cell Mol Neurobiol 41:63\u201378","journal-title":"Cell Mol Neurobiol"},{"key":"1653_CR38","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1002\/ana.25119","volume":"83","author":"AL Greenfield","year":"2018","unstructured":"Greenfield AL, Hauser SL (2018) B-cell therapy for multiple sclerosis: entering an era. Ann Neurol 83:13\u201326","journal-title":"Ann Neurol"},{"key":"1653_CR39","doi-asserted-by":"publisher","first-page":"174480691666055","DOI":"10.1177\/1744806916660557","volume":"12","author":"Y Gu","year":"2016","unstructured":"Gu Y, Wang C, Li G, Huang L-YM (2016) F-actin links Epac-PKC signaling to purinergic P2X3 receptor sensitization in dorsal root ganglia following inflammation. Mol Pain 12:1744806916660557","journal-title":"Mol Pain"},{"key":"1653_CR40","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1016\/j.neuint.2018.11.017","volume":"122","author":"FR Hamann","year":"2019","unstructured":"Hamann FR, Brusco I, de Campos Severo G, de Carvalho LM, Faccin H, Gobo L, Oliveira SM, Rubin MA (2019) Mansoa alliacea extract presents antinociceptive effect in a chronic inflammatory pain model in mice through opioid mechanisms. Neurochem Int 122:157\u2013169","journal-title":"Neurochem Int"},{"key":"1653_CR41","doi-asserted-by":"publisher","first-page":"1677","DOI":"10.1002\/art.20184","volume":"50","author":"Z Helyes","year":"2004","unstructured":"Helyes Z, Szab\u00f3 A, N\u00e9meth J, Jakab B, Pint\u00e9r E, B\u00e1nv\u00f6lgyi A, Kereskai L, K\u00e9ri G, Szolcs\u00e1nyi J (2004) Antiinflammatory and analgesic effects of somatostatin released from capsaicin-sensitive sensory nerve terminals in a Freund\u2019s adjuvant\u2013induced chronic arthritis model in the rat. Arthritis Rheum 50:1677\u20131685","journal-title":"Arthritis Rheum"},{"key":"1653_CR42","doi-asserted-by":"publisher","first-page":"1592","DOI":"10.1097\/j.pain.0000000000003159","volume":"165","author":"JP Higham","year":"2024","unstructured":"Higham JP, Bhebhe CN, Gupta RA, Tranter MM, Barakat FM, Dogra H, Bab N, Wozniak E, Barker KH, Wilson CH (2024) Transcriptomic profiling reveals a pronociceptive role for angiotensin II in inflammatory bowel disease. Pain 165:1592\u20131604","journal-title":"Pain"},{"key":"1653_CR43","doi-asserted-by":"publisher","first-page":"293","DOI":"10.3389\/fimmu.2016.00293","volume":"7","author":"S Hua","year":"2016","unstructured":"Hua S (2016) Neuroimmune interaction in the regulation of peripheral opioid-mediated analgesia in inflammation. Front Immunol 7:293","journal-title":"Front Immunol"},{"key":"1653_CR44","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1016\/j.pharmthera.2009.12.005","volume":"126","author":"AA Izzo","year":"2010","unstructured":"Izzo AA, Sharkey KA (2010) Cannabinoids and the gut: new developments and emerging concepts. Pharmacol Ther 126:21\u201338","journal-title":"Pharmacol Ther"},{"key":"1653_CR45","doi-asserted-by":"publisher","first-page":"1425","DOI":"10.1097\/j.pain.0000000000001857","volume":"161","author":"KA Jacobson","year":"2020","unstructured":"Jacobson KA, Giancotti LA, Lauro F, Mufti F, Salvemini D (2020) Treatment of chronic neuropathic pain: purine receptor modulation. Pain 161:1425\u20131441","journal-title":"Pain"},{"key":"1653_CR46","unstructured":"Jellinger KA 2024 Depression and anxiety in multiple sclerosis. Review of a fatal combination. J Neural Trans, 1\u201323"},{"key":"1653_CR47","doi-asserted-by":"publisher","first-page":"572","DOI":"10.1126\/science.aaf8924","volume":"354","author":"R-R Ji","year":"2016","unstructured":"Ji R-R, Chamessian A, Zhang Y-Q (2016) Pain regulation by non-neuronal cells and inflammation. Science 354:572\u2013577","journal-title":"Science"},{"key":"1653_CR48","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2020.112936","volume":"258","author":"A Karbab","year":"2020","unstructured":"Karbab A, Mokhnache K, Ouhida S, Charef N, Djabi F, Arrar L, Mubarak MS (2020) Anti-inflammatory, analgesic activity, and toxicity of Pituranthos scoparius stem extract: an ethnopharmacological study in rat and mouse models. J Ethnopharmacol 258:112936","journal-title":"J Ethnopharmacol"},{"key":"1653_CR49","doi-asserted-by":"publisher","first-page":"531","DOI":"10.1146\/annurev-pharmtox-032112-135923","volume":"53","author":"V Katritch","year":"2013","unstructured":"Katritch V, Cherezov V, Stevens RC (2013) Structure-function of the G protein\u2013coupled receptor superfamily. Annu Rev Pharmacol Toxicol 53:531\u2013556","journal-title":"Annu Rev Pharmacol Toxicol"},{"key":"1653_CR50","doi-asserted-by":"publisher","first-page":"105211","DOI":"10.1016\/j.neuint.2021.105211","volume":"151","author":"A Khan","year":"2021","unstructured":"Khan A, Shal B, Khan AU, Bibi T, Ul Islam S, Baig MW, Ul Haq I, Ali H, Ahmad S, Khan S (2021) Withametelin, a novel phytosterol, alleviates neurological symptoms in EAE mouse model of multiple sclerosis via modulation of Nrf2\/HO-1 and TLR4\/NF-\u03baB signaling. Neurochem Int 151:105211","journal-title":"Neurochem Int"},{"key":"1653_CR51","doi-asserted-by":"publisher","first-page":"2326","DOI":"10.1002\/ptr.7751","volume":"37","author":"A Khan","year":"2023","unstructured":"Khan A, Shal B, Khan AU, Bibi T, Zeeshan S, Zahra SS, Crews P, Haq IU, Din FU, Ali H (2023) Suppression of MAPK\/NF-kB and activation of Nrf2 signaling by Ajugarin-I in EAE model of multiple sclerosis. Phytother Res 37:2326\u20132343","journal-title":"Phytother Res"},{"key":"1653_CR52","doi-asserted-by":"publisher","first-page":"340","DOI":"10.1016\/j.pain.2010.05.021","volume":"150","author":"WM Knowlton","year":"2010","unstructured":"Knowlton WM, Bifolck-Fisher A, Bautista DM, McKemy DD (2010) TRPM8, but not TRPA1, is required for neural and behavioral responses to acute noxious cold temperatures and cold-mimetics in vivo. Pain 150:340\u2013350","journal-title":"Pain"},{"issue":"4","key":"1653_CR53","doi-asserted-by":"publisher","first-page":"238","DOI":"10.1111\/j.1529-8027.2000.022-8.x","volume":"5","author":"W Koppert","year":"2000","unstructured":"Koppert W, Ostermeier N, Sittl R, Weidner C, Schmelz M (2000) Low-dose lidocaine reduces secondary hyperalgesia by a central mode of action. J Peripher Nerv Syst 5(4):238\u2013238","journal-title":"J Peripher Nerv Syst"},{"key":"1653_CR54","doi-asserted-by":"publisher","first-page":"515","DOI":"10.18388\/abp.2012_2086","volume":"59","author":"D Latek","year":"2012","unstructured":"Latek D, Modzelewska A, Trzaskowski B, Palczewski K, Filipek S (2012) G protein-coupled receptors\u2014recent advances. Acta Biochim Pol 59:515","journal-title":"Acta Biochim Pol"},{"key":"1653_CR55","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2021.114209","volume":"278","author":"J Lee","year":"2021","unstructured":"Lee J, Lim S (2021) Anti-inflammatory, and anti-arthritic effects by the twigs of Cinnamomum cassia on complete Freund\u2019s adjuvant-induced arthritis in rats. J Ethnopharmacol 278:114209","journal-title":"J Ethnopharmacol"},{"key":"1653_CR56","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2021.611773","volume":"9","author":"K Lee","year":"2021","unstructured":"Lee K, Jo YY, Chung G, Jung JH, Kim YH, Park C-K (2021) Functional importance of transient receptor potential (TRP) channels in neurological disorders. Front Cell Develop Biol 9:611773","journal-title":"Front Cell Develop Biol"},{"key":"1653_CR57","doi-asserted-by":"publisher","first-page":"4177","DOI":"10.1002\/ptr.8270","volume":"38","author":"ML Libero","year":"2024","unstructured":"Libero ML, Lucarini E, Recinella L, Ciampi C, Veschi S, Piro A, Chiavaroli A, Acquaviva A, Nilofar N, Orlando G (2024) Anti-inflammatory and anti-hyperalgesic effects induced by an aqueous aged black garlic extract in rodent models of ulcerative colitis and colitis-associated visceral pain. Phytother Res 38:4177\u20134188","journal-title":"Phytother Res"},{"key":"1653_CR58","doi-asserted-by":"publisher","first-page":"74","DOI":"10.3390\/cells7070074","volume":"7","author":"X Liu","year":"2018","unstructured":"Liu X, Ong HL, Ambudkar I (2018) TRP channel involvement in salivary glands\u2014some good, some bad. Cells 7:74","journal-title":"Cells"},{"key":"1653_CR59","doi-asserted-by":"publisher","first-page":"1448","DOI":"10.3390\/ijms22031448","volume":"22","author":"JA Liu","year":"2021","unstructured":"Liu JA, Yu J, Cheung CW (2021) Immune actions on the peripheral nervous system in pain. Int J Mol Sci 22:1448","journal-title":"Int J Mol Sci"},{"key":"1653_CR60","doi-asserted-by":"publisher","first-page":"1388","DOI":"10.3389\/fphar.2018.01388","volume":"9","author":"H Machelska","year":"2018","unstructured":"Machelska H, Celik M\u00d6 (2018) Advances in achieving opioid analgesia without side effects. Front Pharmacol 9:1388","journal-title":"Front Pharmacol"},{"key":"1653_CR61","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1016\/j.imr.2017.11.002","volume":"7","author":"HJ Mahdi","year":"2018","unstructured":"Mahdi HJ, Khan NAK, Asmawi MZB, Mahmud R, Vikneswaran A, Murugaiyah L (2018) In vivo anti-arthritic and anti-nociceptive effects of ethanol extract of Moringa oleifera leaves on complete Freund\u2019s adjuvant (CFA)-induced arthritis in rats. Integrative Medicine Research 7:85\u201394","journal-title":"Integrative Medicine Research"},{"key":"1653_CR62","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1515\/sjpain-2019-0138","volume":"20","author":"M Malcangio","year":"2019","unstructured":"Malcangio M (2019) Role of the immune system in neuropathic pain. Scandinavian J Pain 20:33\u201337","journal-title":"Scandinavian J Pain"},{"key":"1653_CR63","doi-asserted-by":"publisher","first-page":"104483","DOI":"10.1016\/j.jff.2021.104483","volume":"82","author":"D Maria-Ferreira","year":"2021","unstructured":"Maria-Ferreira D, Dallazen JL, Corso CR, Nascimento AM, Cipriani TR, da Silva Watanabe P, Sant\u2019ana DDMG, Baggio CH, Paula Werner MF (2021) Rhamnogalacturonan polysaccharide inhibits inflammation and oxidative stress and alleviates visceral pain. J Funct Foods 82:104483","journal-title":"J Funct Foods"},{"key":"1653_CR64","doi-asserted-by":"publisher","first-page":"4132","DOI":"10.1111\/febs.15846","volume":"289","author":"K Maruyama","year":"2022","unstructured":"Maruyama K (2022) Senso-immunology: crosstalk between nociceptive and immune systems. FEBS J 289:4132\u20134145","journal-title":"FEBS J"},{"key":"1653_CR65","doi-asserted-by":"publisher","first-page":"178","DOI":"10.3389\/fphar.2016.00178","volume":"7","author":"S Mathivanan","year":"2016","unstructured":"Mathivanan S, Devesa I, Changeux J-P, Ferrer-Montiel A (2016) Bradykinin induces TRPV1 exocytotic recruitment in peptidergic nociceptors. Front Pharmacol 7:178","journal-title":"Front Pharmacol"},{"key":"1653_CR66","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s12891-016-1192-7","volume":"17","author":"DF McWilliams","year":"2016","unstructured":"McWilliams DF, Walsh DA (2016) Factors predicting pain and early discontinuation of tumour necrosis factor-\u03b1-inhibitors in people with rheumatoid arthritis: results from the British society for rheumatology biologics register. BMC Musculoskelet Disord 17:1\u201317","journal-title":"BMC Musculoskelet Disord"},{"key":"1653_CR67","doi-asserted-by":"publisher","first-page":"130","DOI":"10.1016\/j.tins.2020.01.001","volume":"43","author":"J Meixiong","year":"2020","unstructured":"Meixiong J, Basso L, Dong X, Gaudenzio N (2020) Nociceptor\u2013mast cell sensory clusters as regulators of skin homeostasis. Trends Neurosci 43:130\u2013132","journal-title":"Trends Neurosci"},{"key":"1653_CR68","doi-asserted-by":"crossref","unstructured":"Miller RJ, Jung H, Bhangoo SK, White FA, 2009 Cytokine and chemokine regulation of sensory neuron function. Sensory Nerves, 417\u2013449","DOI":"10.1007\/978-3-540-79090-7_12"},{"key":"1653_CR69","doi-asserted-by":"publisher","first-page":"342","DOI":"10.3390\/antiox8090342","volume":"8","author":"C Nasuti","year":"2019","unstructured":"Nasuti C, Fedeli D, Bordoni L, Piangerelli M, Servili M, Selvaggini R, Gabbianelli R (2019) Anti-inflammatory, anti-arthritic and anti-nociceptive activities of Nigella sativa oil in a rat model of arthritis. Antioxidants 8:342","journal-title":"Antioxidants"},{"key":"1653_CR70","doi-asserted-by":"crossref","unstructured":"Nikolenko VN, Shelomentseva EM, Tsvetkova MM, Abdeeva EI, Giller DB, Babayeva JV, Achkasov EE, Gavryushova LV, Sinelnikov MY, 2022 Nociceptors: their role in body\u2019s defenses, tissue specific variations and anatomical update. J Pain Res, 867\u2013877","DOI":"10.2147\/JPR.S348324"},{"key":"1653_CR71","doi-asserted-by":"publisher","first-page":"3922","DOI":"10.1002\/jcb.26534","volume":"119","author":"P Nu\u00f1ez-Badinez","year":"2018","unstructured":"Nu\u00f1ez-Badinez P, Sep\u00falveda H, Diaz E, Greffrath W, Treede RD, Stehberg J, Montecino M, van Zundert B (2018) Variable transcriptional responsiveness of the P2X3 receptor gene during CFA-induced inflammatory hyperalgesia. J Cell Biochem 119:3922\u20133935","journal-title":"J Cell Biochem"},{"key":"1653_CR72","doi-asserted-by":"publisher","first-page":"1309583","DOI":"10.3389\/fimmu.2024.1309583","volume":"15","author":"H Ouyang","year":"2024","unstructured":"Ouyang H, Li X, Xu H, Zhan Y, Zheng Z, Chen G, Lou Z, Chen H, Zhang J, Mao H (2024) Risk factors of neuropathic pain in multiple sclerosis: a retrospective case-cohort study. Front Immunol 15:1309583","journal-title":"Front Immunol"},{"key":"1653_CR73","unstructured":"Pablo-P\u00e9rez SS, Parada-Cruz B, Barbier OC, Mel\u00e9ndez-Camargo ME 2018 The ethanolic extract of Eysenhardtia polystachya (Ort.) Sarg. bark and its fractions delay the progression of rheumatoid arthritis and show antinociceptive activity in murine models. Iranian journal of pharmaceutical research: IJPR, 17, 236"},{"key":"1653_CR74","doi-asserted-by":"publisher","first-page":"2824","DOI":"10.1002\/jcp.25993","volume":"233","author":"MC Pace","year":"2018","unstructured":"Pace MC, Passavanti MB, de Nardis L, Bosco F, Sansone P, Pota V, Barbarisi M, Palagiano A, Iannotti FA, Panza E (2018) Nociceptor plasticity: a closer look. J Cell Physiol 233:2824\u20132838","journal-title":"J Cell Physiol"},{"key":"1653_CR75","doi-asserted-by":"publisher","first-page":"106","DOI":"10.1016\/j.intimp.2016.10.024","volume":"41","author":"P Palit","year":"2016","unstructured":"Palit P, Mandal SC, Bhunia B (2016) Total steroid and terpenoid enriched fraction from Euphorbia neriifolia Linn offers protection against nociceptive-pain, inflammation, and in vitro arthritis model: an insight of mechanistic study. Int Immunopharmacol 41:106\u2013115","journal-title":"Int Immunopharmacol"},{"key":"1653_CR76","doi-asserted-by":"publisher","first-page":"2628","DOI":"10.3748\/wjg.v29.i17.2628","volume":"29","author":"GC Peiter","year":"2023","unstructured":"Peiter GC, Queiroz TKM, Michalkiewicz EL Jr, Chappuis RH, Luz JS, Piovezani LHC, Silva CF, Tsutumi MN, Chaves AF, Luiz RM (2023) Lafoensia pacari alleviates intestinal damage by modulating cyclooxygenase-2: In silico and in vivo evaluation in a colitis model. World J Gastroenterol 29:2628","journal-title":"World J Gastroenterol"},{"key":"1653_CR77","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1016\/j.it.2016.10.001","volume":"38","author":"FA Pinho-Ribeiro","year":"2017","unstructured":"Pinho-Ribeiro FA, Verri WA, Chiu IM (2017) Nociceptor sensory neuron\u2013immune interactions in pain and inflammation. Trends Immunol 38:5\u201319","journal-title":"Trends Immunol"},{"key":"1653_CR78","doi-asserted-by":"publisher","first-page":"509","DOI":"10.1038\/s41581-023-00720-1","volume":"19","author":"DS Pisetsky","year":"2023","unstructured":"Pisetsky DS (2023) Pathogenesis of autoimmune disease. Nature Rev Nephrol 19:509\u2013524","journal-title":"Nature Rev Nephrol"},{"key":"1653_CR79","doi-asserted-by":"publisher","first-page":"279","DOI":"10.1016\/j.neuroscience.2015.01.030","volume":"290","author":"A Rahimi","year":"2015","unstructured":"Rahimi A, Faizi M, Talebi F, Noorbakhsh F, Kahrizi F, Naderi N (2015) Interaction between the protective effects of cannabidiol and palmitoylethanolamide in experimental model of multiple sclerosis in C57BL\/6 mice. Neuroscience 290:279\u2013287","journal-title":"Neuroscience"},{"key":"1653_CR80","doi-asserted-by":"publisher","first-page":"429","DOI":"10.1093\/rheumatology\/kex308","volume":"57","author":"R Raoof","year":"2018","unstructured":"Raoof R, Willemen HL, Eijkelkamp N (2018) Divergent roles of immune cells and their mediators in pain. Rheumatology 57:429\u2013440","journal-title":"Rheumatology"},{"key":"1653_CR81","doi-asserted-by":"publisher","first-page":"8465","DOI":"10.3390\/app10238465","volume":"10","author":"J Rocha","year":"2020","unstructured":"Rocha J, Leandro R, Direito R, Gon\u00e7alves M, Duarte MP, Fernandes A, Sepodes B, Figueira M-E (2020) Attenuation of colonic injury and inflammation by administration of a phenolic extract of summer savory (Satureja hortensis L.) in experimental inflammatory bowel disease in mice. Appl Sci 10:8465","journal-title":"Appl Sci"},{"key":"1653_CR82","doi-asserted-by":"publisher","first-page":"86","DOI":"10.1038\/s41575-023-00854-4","volume":"21","author":"JJ Rudbaek","year":"2024","unstructured":"Rudbaek JJ, Agrawal M, Torres J, Mehandru S, Colombel J-F, Jess T (2024) Deciphering the different phases of preclinical inflammatory bowel disease. Nat Rev Gastroenterol Hepatol 21:86\u2013100","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"1653_CR83","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2022.967644","volume":"13","author":"AJ Ruiz-Malag\u00f3n","year":"2022","unstructured":"Ruiz-Malag\u00f3n AJ, Rodr\u00edguez-Sanchez MJ, Rodr\u00edguez-Sojo MJ, Vezza T, Pischel I, Algieri F, Rodr\u00edguez-Cabezas ME, Rodr\u00edguez-Nogales A, G\u00e1lvez J (2022) Intestinal anti-inflammatory and visceral analgesic effects of a Serpylli herba extract in an experimental model of irritable bowel syndrome in rats. Front Pharmacol 13:967644","journal-title":"Front Pharmacol"},{"key":"1653_CR84","doi-asserted-by":"publisher","first-page":"671","DOI":"10.1038\/s41584-024-01155-z","volume":"20","author":"Z Rutter-Locher","year":"2024","unstructured":"Rutter-Locher Z, Kirkham BW, Bannister K, Bennett DL, Buckley CD, Taams LS, Denk F (2024) An interdisciplinary perspective on peripheral drivers of pain in rheumatoid arthritis. Nature Rev Rheumatol 20:671\u2013682","journal-title":"Nature Rev Rheumatol"},{"key":"1653_CR85","doi-asserted-by":"publisher","first-page":"843","DOI":"10.1080\/1028415X.2019.1681742","volume":"24","author":"H Safari","year":"2021","unstructured":"Safari H, Anani Sarab G, SNaseri M (2021) Artemisia dracunculus L. modulates the immune system in a multiple sclerosis mouse model. Nutr Neurosci 24:843\u2013849","journal-title":"Nutr Neurosci"},{"key":"1653_CR86","doi-asserted-by":"crossref","unstructured":"Sarzi-Puttini P, Zen M, Arru F, Giorgi V, Choy EA 2023 Residual pain in rheumatoid arthritis: is it a real problem? Autoimmunity Rev, 103423","DOI":"10.1016\/j.autrev.2023.103423"},{"key":"1653_CR87","doi-asserted-by":"publisher","DOI":"10.1016\/j.conctc.2021.100770","volume":"22","author":"HM Schenker","year":"2021","unstructured":"Schenker HM, Tascilar K, Konerth L, Sergeeva M, Prade J, Strobelt S, Kleyer A, Simon D, Mendez L, Hagen M, Sch\u00f6nau V (2021) Prediction of response to Certolizumab-Pegol in rheumatoid arthritis (PreCePRA) by functional MRI of the brain\u2013Study protocol for a randomized double-blind controlled study. Contemporary Clin Trials Commun 22:100770","journal-title":"Contemporary Clin Trials Commun"},{"key":"1653_CR88","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1097\/j.pain.0000000000001365","volume":"160","author":"J Scholz","year":"2019","unstructured":"Scholz J, Finnerup NB, Attal N, Aziz Q, Baron R, Bennett MI, Benoliel R, Cohen M, Cruccu G, Davis KD (2019) The IASP classification of chronic pain for ICD-11: chronic neuropathic pain. Pain 160:53\u201359","journal-title":"Pain"},{"key":"1653_CR89","doi-asserted-by":"publisher","first-page":"112350","DOI":"10.1016\/j.jep.2019.112350","volume":"248","author":"S Shanmugam","year":"2020","unstructured":"Shanmugam S, Thangaraj P, dos Santos LB, Trindade GG, Narain N, Silva AM, Santin JR, Broering MF, Serafini MR, Quintans-J\u00fanior LJ (2020) Protective effects of flavonoid composition rich P subpeltata Ortega on indomethacin induced experimental ulcerative colitis in rat models of inflammatory bowel diseases. J Ethnopharmacol 248:112350","journal-title":"J Ethnopharmacol"},{"key":"1653_CR90","doi-asserted-by":"publisher","first-page":"407","DOI":"10.1016\/j.mcn.2005.10.011","volume":"31","author":"VI Shubayev","year":"2006","unstructured":"Shubayev VI, Angert M, Dolkas J, Campana WM, Palenscar K, Myers RR (2006) TNF\u03b1-induced MMP-9 promotes macrophage recruitment into injured peripheral nerve. Mol Cell Neurosci 31:407\u2013415","journal-title":"Mol Cell Neurosci"},{"key":"1653_CR91","doi-asserted-by":"publisher","first-page":"180","DOI":"10.1016\/j.bbi.2017.11.011","volume":"69","author":"J Song","year":"2018","unstructured":"Song J, Ying Y, Wang W, Liu X, Xu X, Wei X, Ruan X (2018) The role of P2X7R\/ERK signaling in dorsal root ganglia satellite glial cells in the development of chronic postsurgical pain induced by skin\/muscle incision and retraction (SMIR). Brain Behav Immun 69:180\u2013189","journal-title":"Brain Behav Immun"},{"key":"1653_CR92","doi-asserted-by":"publisher","first-page":"6053","DOI":"10.2174\/138161212803582513","volume":"18","author":"C Stein","year":"2012","unstructured":"Stein C, Kuchler S (2012) Non-analgesic effects of opioids: peripheral opioid effects on inflammation and wound healing. Curr Pharm des 18:6053\u20136069","journal-title":"Curr Pharm des"},{"key":"1653_CR93","doi-asserted-by":"publisher","first-page":"585","DOI":"10.1038\/s41584-021-00652-9","volume":"17","author":"Z Szekanecz","year":"2021","unstructured":"Szekanecz Z, McInnes IB, Schett G, Szamosi S, Benk\u0151 S, Sz\u0171cs G (2021) Autoinflammation and autoimmunity across rheumatic and musculoskeletal diseases. Nat Rev Rheumatol 17:585\u2013595","journal-title":"Nat Rev Rheumatol"},{"key":"1653_CR94","doi-asserted-by":"publisher","first-page":"287","DOI":"10.1016\/j.tins.2008.03.002","volume":"31","author":"K Talavera","year":"2008","unstructured":"Talavera K, Nilius B, Voets T (2008) Neuronal TRP channels: thermometers, pathfinders and life-savers. Trends Neurosci 31:287\u2013295","journal-title":"Trends Neurosci"},{"key":"1653_CR95","doi-asserted-by":"publisher","first-page":"295","DOI":"10.1038\/cmi.2018.9","volume":"15","author":"P Tang","year":"2018","unstructured":"Tang P, Wang JM (2018) Chemokines: the past, the present and the future. Cell Mol Immunol 15:295\u2013298","journal-title":"Cell Mol Immunol"},{"issue":"1","key":"1653_CR96","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1111\/pme.12569","volume":"16","author":"D Turcotte","year":"2015","unstructured":"Turcotte D, Doupe M, Torabi M, Gomori A, Ethans K, Esfahani F, Galloway K, Namaka M (2015) Nabilone as an adjunctive to gabapentin for multiple sclerosis-induced neuropathic pain: a randomized controlled trial. Pain Med 16(1):149\u2013159","journal-title":"Pain Med"},{"issue":"2628\u20132641","key":"1653_CR97","volume":"38","author":"M-C Vieira","year":"2016","unstructured":"Vieira M-C, Zwillich SH, Jansen JP, Smiechowski B, Spurden D, Wallenstein GV (2016) Tofacitinib versus biologic treatments in patients with active rheumatoid arthritis who have had an inadequate response to tumor necrosis factor inhibitors: results from a network meta-analysis. Clin Ther 38(2628\u20132641):e5","journal-title":"Clin Ther"},{"key":"1653_CR98","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1038\/aps.2015.127","volume":"37","author":"J Wang","year":"2016","unstructured":"Wang J, Yu Y (2016) Insights into the channel gating of P2X receptors from structures, dynamics and small molecules. Acta Pharmacol Sin 37:44\u201355","journal-title":"Acta Pharmacol Sin"},{"key":"1653_CR99","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1038\/s41385-021-00443-1","volume":"15","author":"H Wang","year":"2022","unstructured":"Wang H, Foong JP, Harris NL, Bornstein JC (2022) Enteric neuroimmune interactions coordinate intestinal responses in health and disease. Mucosal Immunol 15:27\u201339","journal-title":"Mucosal Immunol"},{"key":"1653_CR100","volume-title":"Translational Research in pain and itch","author":"T Wang","year":"2024","unstructured":"Wang T, Ma C (2024) Peripheral nociceptors as immune sensors in the development of pain and itch. Translational Research in pain and itch. Springer"},{"key":"1653_CR101","doi-asserted-by":"publisher","first-page":"649","DOI":"10.1007\/s00296-017-3925-9","volume":"38","author":"S Won","year":"2018","unstructured":"Won S, Cho S-K, Kim D, Han M, Lee J, Jang EJ, Sung Y-K, Bae S-C (2018) Update on the prevalence and incidence of rheumatoid arthritis in Korea and an analysis of medical care and drug utilization. Rheumatol Int 38:649\u2013656","journal-title":"Rheumatol Int"},{"key":"1653_CR102","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.870952","volume":"13","author":"T Xiao","year":"2022","unstructured":"Xiao T, Sun M, Kang J, Zhao C (2022) Transient receptor potential Vanilloid1 (TRPV1) Channel opens Sesame of T cell responses and T cell-mediated inflammatory diseases. Front Immunol 13:870952","journal-title":"Front Immunol"},{"key":"1653_CR103","doi-asserted-by":"publisher","first-page":"2164","DOI":"10.3390\/ijms19082164","volume":"19","author":"MF Yam","year":"2018","unstructured":"Yam MF, Loh YC, Tan CS, Khadijah Adam S, Abdul Manan N, Basir R (2018) General pathways of pain sensation and the major neurotransmitters involved in pain regulation. Int J Mole Sci 19:2164","journal-title":"Int J Mole Sci"},{"key":"1653_CR104","first-page":"7980","volume":"17","author":"M Yu","year":"2018","unstructured":"Yu M, Zhao Y, Zhang X (2018) Gardenoside combined with ozone inhibits the expression of P2X3 and P2X7 purine receptors in rats with sciatic nerve injury. Mol Med Rep 17:7980\u20137986","journal-title":"Mol Med Rep"},{"key":"1653_CR105","doi-asserted-by":"publisher","first-page":"1031","DOI":"10.1016\/j.jpain.2013.03.012","volume":"14","author":"H Zhang","year":"2013","unstructured":"Zhang H, Boyette-Davis JA, Kosturakis AK, Li Y, Yoon S-Y, Walters ET, Dougherty PM (2013) Induction of monocyte chemoattractant protein-1 (MCP-1) and its receptor CCR2 in primary sensory neurons contributes to paclitaxel-induced peripheral neuropathy. J Pain 14:1031\u20131044","journal-title":"J Pain"},{"key":"1653_CR106","doi-asserted-by":"publisher","first-page":"174480691769921","DOI":"10.1177\/1744806917699212","volume":"13","author":"M Zhuo","year":"2017","unstructured":"Zhuo M (2017) Descending facilitation: from basic science to the treatment of chronic pain. Mole Pain 13:1744806917699212","journal-title":"Mole Pain"},{"key":"1653_CR107","doi-asserted-by":"publisher","first-page":"419","DOI":"10.1097\/MIB.0000000000000234","volume":"21","author":"M Zieli\u0144ska","year":"2015","unstructured":"Zieli\u0144ska M, Jarmu\u017c A, Wasilewski A, Sa\u0142aga M, Fichna J (2015) Role of transient receptor potential channels in intestinal inflammation and visceral pain: novel targets in inflammatory bowel diseases. Inflamm Bowel Dis 21:419\u2013427","journal-title":"Inflamm Bowel Dis"}],"container-title":["Inflammopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10787-025-01653-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10787-025-01653-w\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10787-025-01653-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,18]],"date-time":"2025-03-18T13:15:18Z","timestamp":1742303718000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10787-025-01653-w"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2,16]]},"references-count":107,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2025,3]]}},"alternative-id":["1653"],"URL":"https:\/\/doi.org\/10.1007\/s10787-025-01653-w","relation":{},"ISSN":["0925-4692","1568-5608"],"issn-type":[{"value":"0925-4692","type":"print"},{"value":"1568-5608","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,2,16]]},"assertion":[{"value":"13 November 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 January 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 February 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors have no relevant financial or non-financial interests to disclose.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"N\/A.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"N\/A.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}},{"value":"N\/A.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to publish"}}]}}