{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T08:56:52Z","timestamp":1789117012067,"version":"build-2803163510"},"reference-count":25,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2025,2,26]],"date-time":"2025-02-26T00:00:00Z","timestamp":1740528000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,2,26]],"date-time":"2025-02-26T00:00:00Z","timestamp":1740528000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Inflammopharmacol"],"published-print":{"date-parts":[[2025,3]]},"DOI":"10.1007\/s10787-025-01696-z","type":"journal-article","created":{"date-parts":[[2025,2,26]],"date-time":"2025-02-26T11:32:21Z","timestamp":1740569541000},"page":"1381-1391","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Dissolving microneedle patch for transdermal delivery of perindopril erbumine"],"prefix":"10.1007","volume":"33","author":[{"given":"Zunaira","family":"Altaf","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2565-7223","authenticated-orcid":false,"given":"Zulcaif","family":"Ahmad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asif","family":"Mahmood","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saniia","family":"Shchinar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Riffat","family":"Latif","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,2,26]]},"reference":[{"issue":"2","key":"1696_CR1","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1208\/s12249-019-1611-9","volume":"21","author":"Z Ahmad","year":"2020","unstructured":"Ahmad Z, Khan MI, Siddique MI, Sarwar HS, Shahnaz G, Hussain SZ, Bukhari NI, Hussain I, Sohail MF (2020) Fabrication and characterization of thiolated chitosan microneedle patch for transdermal delivery of tacrolimus. AAPS PharmSciTech 21(2):68. https:\/\/doi.org\/10.1208\/s12249-019-1611-9","journal-title":"AAPS PharmSciTech"},{"issue":"9","key":"1696_CR2","doi-asserted-by":"publisher","first-page":"896","DOI":"10.1080\/10837450.2023.2272863","volume":"28","author":"Z Ahmad","year":"2023","unstructured":"Ahmad Z, Zafar N, Mahmood A, Sarfraz RM, Latif R, Gad HA (2023) Fast dissolving microneedle patch for pronounced systemic delivery of an antihyperlipidemic drug. Pharm Dev Technol 28(9):896\u2013906","journal-title":"Pharm Dev Technol"},{"issue":"3","key":"1696_CR3","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1515\/bmt-2019-0019","volume":"65","author":"N Akhtar","year":"2020","unstructured":"Akhtar N, Singh V, Yusuf M, Khan RA (2020) Non-invasive drug delivery technology: development and current status of transdermal drug delivery devices, techniques and biomedical applications. Biomed Eng\/biomedizinische Technik 65(3):243\u2013272","journal-title":"Biomed Eng\/biomedizinische Technik"},{"issue":"1","key":"1696_CR4","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1016\/j.jconrel.2012.09.017","volume":"164","author":"A Alexander","year":"2012","unstructured":"Alexander A, Dwivedi S, Giri TK, Saraf S, Saraf S, Tripathi DK (2012) Approaches for breaking the barriers of drug permeation through transdermal drug delivery. J Control Release 164(1):26\u201340","journal-title":"J Control Release"},{"issue":"10","key":"1696_CR5","doi-asserted-by":"publisher","first-page":"1016","DOI":"10.1080\/10837450.2023.2285498","volume":"28","author":"RK Andranilla","year":"2023","unstructured":"Andranilla RK, Anjani QK, Hartrianti P, Donnelly RF, Ramadon D (2023) Fabrication of dissolving microneedles for transdermal delivery of protein and peptide drugs: polymer materials and solvent casting micromoulding method. Pharm Dev Technol 28(10):1016\u20131031","journal-title":"Pharm Dev Technol"},{"key":"1696_CR6","doi-asserted-by":"publisher","first-page":"1290","DOI":"10.1016\/j.csbj.2019.09.004","volume":"17","author":"R Bajracharya","year":"2019","unstructured":"Bajracharya R, Song JG, Back SY, Han H-K (2019) Recent advancements in non-invasive formulations for protein drug delivery. Comput Struct Biotechnol J 17:1290\u20131308","journal-title":"Comput Struct Biotechnol J"},{"issue":"20","key":"1696_CR7","doi-asserted-by":"publisher","first-page":"10012","DOI":"10.7150\/thno.66478","volume":"11","author":"B Cai","year":"2021","unstructured":"Cai B, Gong Y, Wang Z, Wang L, Chen W (2021) Microneedle arrays integrated with living organisms for smart biomedical applications. Theranostics 11(20):10012","journal-title":"Theranostics"},{"key":"1696_CR8","doi-asserted-by":"publisher","DOI":"10.1016\/j.jddst.2021.102711","volume":"65","author":"NT Chevala","year":"2021","unstructured":"Chevala NT, Jitta SR, Marques SM, Vaz VM, Kumar L (2021) Polymeric microneedles for transdermal delivery of nanoparticles: frontiers of formulation, sterility and stability aspects. J Drug Delivery Sci Technol 65:102711","journal-title":"J Drug Delivery Sci Technol"},{"issue":"2","key":"1696_CR9","doi-asserted-by":"publisher","first-page":"190","DOI":"10.3390\/ph15020190","volume":"15","author":"F Damiri","year":"2022","unstructured":"Damiri F, Kommineni N, Ebhodaghe SO, Bulusu R, Jyothi VGS, Sayed AA, Awaji AA, Germoush MO, Al-Malky HS, Nasrullah MZ (2022) Microneedle-based natural polysaccharide for drug delivery systems (DDS): progress and challenges. Pharmaceuticals 15(2):190","journal-title":"Pharmaceuticals"},{"key":"1696_CR10","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1016\/j.ejpb.2019.01.005","volume":"136","author":"S Duarah","year":"2019","unstructured":"Duarah S, Sharma M, Wen J (2019) Recent advances in microneedle-based drug delivery: special emphasis on its use in paediatric population. Eur J Pharm Biopharm 136:48\u201369","journal-title":"Eur J Pharm Biopharm"},{"key":"1696_CR11","first-page":"585","volume-title":"Delivery of drugs, vaccines, and cosmeceuticals to skin using microneedle patches Percutaneous Absorption","author":"Y Gomaa","year":"2021","unstructured":"Gomaa Y, Prausnitz MR (2021) Delivery of drugs, vaccines, and cosmeceuticals to skin using microneedle patches Percutaneous Absorption. CRC Press, pp 585\u2013608"},{"issue":"1","key":"1696_CR12","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1007\/s12045-022-1294-5","volume":"27","author":"BJ Gowda","year":"2022","unstructured":"Gowda BJ, Ahmed MG, Sanjana A (2022) Can microneedles replace hypodermic needles? Painless drug delivery. Resonance 27(1):63\u201385","journal-title":"Resonance"},{"issue":"sup2","key":"1696_CR13","doi-asserted-by":"publisher","first-page":"539","DOI":"10.1080\/21691401.2018.1463230","volume":"46","author":"AK Goyal","year":"2018","unstructured":"Goyal AK, Singh R, Chauhan G, Rath G (2018) Non-invasive systemic drug delivery through mucosal routes. Artif Cells, Nanomed, Biotechnol 46(sup2):539\u2013551","journal-title":"Artif Cells, Nanomed, Biotechnol"},{"key":"1696_CR14","doi-asserted-by":"publisher","first-page":"275","DOI":"10.1201\/9781003014935-7","volume-title":"Microneedles: current trends and applications Microfluidics and Bio-MEMS","author":"H Manoj","year":"2020","unstructured":"Manoj H, Gupta P, Mohan L, Nagai M, Wankhar S, Santra TS (2020) Microneedles: current trends and applications Microfluidics and Bio-MEMS. Jenny Stanford Publishing, pp 275\u2013342"},{"issue":"1","key":"1696_CR15","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1002\/jps.21793","volume":"99","author":"NR Mathias","year":"2010","unstructured":"Mathias NR, Hussain MA (2010) Non-invasive systemic drug delivery: developability considerations for alternate routes of administration. J Pharm Sci 99(1):1\u201320","journal-title":"J Pharm Sci"},{"key":"1696_CR16","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1016\/j.jare.2020.07.017","volume":"26","author":"F Meng","year":"2020","unstructured":"Meng F, Hasan A, Babadaei MMN, Kani PH, Talaei AJ, Sharifi M, Cai T, Falahati M, Cai Y (2020) Polymeric-based microneedle arrays as potential platforms in the development of drugs delivery systems. J Adv Res 26:137\u2013147","journal-title":"J Adv Res"},{"key":"1696_CR17","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1208\/s12249-021-02186-5","volume":"23","author":"A Prabhu","year":"2022","unstructured":"Prabhu A, Jose J, Kumar L, Salwa S, Vijay Kumar M, Nabavi SM (2022) Transdermal delivery of curcumin-loaded solid lipid nanoparticles as microneedle patch: an in vitro and in vivo study. AAPS PharmSciTech 23:1\u201312","journal-title":"AAPS PharmSciTech"},{"key":"1696_CR18","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1146\/annurev-chembioeng-060816-101514","volume":"8","author":"MR Prausnitz","year":"2017","unstructured":"Prausnitz MR (2017) Engineering microneedle patches for vaccination and drug delivery to skin. Annu Rev Chem Biomol Eng 8:177\u2013200","journal-title":"Annu Rev Chem Biomol Eng"},{"issue":"8","key":"1696_CR19","doi-asserted-by":"publisher","first-page":"2936","DOI":"10.1208\/s12249-017-0774-5","volume":"18","author":"V Shah","year":"2017","unstructured":"Shah V, Choudhury BK (2017) Fabrication, physicochemical characterization, and performance evaluation of biodegradable polymeric microneedle patch system for enhanced transcutaneous flux of high molecular weight therapeutics. AAPS PharmSciTech 18(8):2936\u20132948","journal-title":"AAPS PharmSciTech"},{"issue":"3","key":"1696_CR20","doi-asserted-by":"publisher","DOI":"10.1002\/wnan.1778","volume":"14","author":"H Shang","year":"2022","unstructured":"Shang H, Younas A, Zhang N (2022) Recent advances on transdermal delivery systems for the treatment of arthritic injuries: from classical treatment to nanomedicines. Wires Nanomed Nanobiotechnol 14(3):e1778. https:\/\/doi.org\/10.1002\/wnan.1778","journal-title":"Wires Nanomed Nanobiotechnol"},{"key":"1696_CR21","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2024.124289","volume":"660","author":"AO Tijani","year":"2024","unstructured":"Tijani AO, Connors D, Schiavone C, Pel\u00e1ez MJ, Dogra P, Puri A (2024) Iontophoresis-coupled rapidly dissolving polymeric microneedle patch of naloxone for its enhanced transdermal delivery. Int J Pharm 660:124289. https:\/\/doi.org\/10.1016\/j.ijpharm.2024.124289","journal-title":"Int J Pharm"},{"issue":"11","key":"1696_CR22","doi-asserted-by":"publisher","first-page":"961","DOI":"10.3390\/mi11110961","volume":"11","author":"A Tucak","year":"2020","unstructured":"Tucak A, Sirbubalo M, Hindija L, Rahi\u0107 O, Had\u017eiabdi\u0107 J, Muhamedagi\u0107 K, \u010ceki\u0107 A, Vrani\u0107 E (2020) Microneedles: characteristics, materials, production methods and commercial development. Micromachines 11(11):961","journal-title":"Micromachines"},{"issue":"2","key":"1696_CR23","doi-asserted-by":"publisher","first-page":"2000307","DOI":"10.1002\/mabi.202000307","volume":"21","author":"JG Turner","year":"2021","unstructured":"Turner JG, White LR, Estrela P, Leese HS (2021) Hydrogel-forming microneedles: current advancements and future trends. Macromol Biosci 21(2):2000307","journal-title":"Macromol Biosci"},{"key":"1696_CR24","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1016\/j.ejpb.2020.12.006","volume":"159","author":"LK Vora","year":"2021","unstructured":"Vora LK, Moffatt K, Tekko IA, Paredes AJ, Volpe-Zanutto F, Mishra D, Peng K, Thakur RRS, Donnelly RF (2021) Microneedle array systems for long-acting drug delivery. Eur J Pharm Biopharm 159:44\u201376","journal-title":"Eur J Pharm Biopharm"},{"issue":"8","key":"1696_CR25","doi-asserted-by":"publisher","first-page":"1304","DOI":"10.3390\/mi13081304","volume":"13","author":"N Zulcaif Zafar","year":"2022","unstructured":"Zulcaif Zafar N, Mahmood A, Sarfraz RM, Elaissari A (2022) Simvastatin loaded dissolvable microneedle patches with improved pharmacokinetic performance. Micromachines 13(8):1304","journal-title":"Micromachines"}],"container-title":["Inflammopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10787-025-01696-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10787-025-01696-z\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10787-025-01696-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,18]],"date-time":"2025-03-18T13:19:11Z","timestamp":1742303951000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10787-025-01696-z"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2,26]]},"references-count":25,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2025,3]]}},"alternative-id":["1696"],"URL":"https:\/\/doi.org\/10.1007\/s10787-025-01696-z","relation":{},"ISSN":["0925-4692","1568-5608"],"issn-type":[{"value":"0925-4692","type":"print"},{"value":"1568-5608","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,2,26]]},"assertion":[{"value":"15 January 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"31 January 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 February 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Authors declare that they have no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"This study approval was taken from the Animal Ethical Committee vide letter No. RIU\/RIPS\/24\/2084 dated April 13, 2024.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"Not applicable.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}},{"value":"Not applicable.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to publish"}}]}}