{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,30]],"date-time":"2026-05-30T03:12:27Z","timestamp":1780110747724,"version":"3.54.0"},"reference-count":119,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2025,4,12]],"date-time":"2025-04-12T00:00:00Z","timestamp":1744416000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,4,12]],"date-time":"2025-04-12T00:00:00Z","timestamp":1744416000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Inflammopharmacol"],"published-print":{"date-parts":[[2025,5]]},"DOI":"10.1007\/s10787-025-01731-z","type":"journal-article","created":{"date-parts":[[2025,4,12]],"date-time":"2025-04-12T05:59:49Z","timestamp":1744437589000},"page":"2263-2275","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Role of polyphenolics in the management of rheumatoid arthritis through intracellular signaling pathways: a mechanistic review"],"prefix":"10.1007","volume":"33","author":[{"given":"Uzma","family":"Saleem","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5439-0284","authenticated-orcid":false,"given":"Maryam","family":"Farrukh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Malik","family":"Saadullah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rida","family":"Siddique","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Humaira","family":"Gul","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aqsa","family":"Ahmad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bushra","family":"Shaukat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammad Ajmal","family":"Shah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,4,12]]},"reference":[{"key":"1731_CR1","doi-asserted-by":"publisher","first-page":"2393","DOI":"10.1002\/art.22023","volume":"54","author":"S Ahmed","year":"2006","unstructured":"Ahmed S, Pakozdi A, Koch AE (2006) Regulation of interleukin-1\u03b2\u2013induced chemokine production and matrix metalloproteinase 2 activation by epigallocatechin-3-gallate in rheumatoid arthritis synovial fibroblasts. Arthritis Rheum 54:2393\u20132401","journal-title":"Arthritis Rheum"},{"key":"1731_CR2","doi-asserted-by":"publisher","first-page":"148","DOI":"10.1016\/j.bbrc.2003.11.108","volume":"313","author":"S-C Ahn","year":"2004","unstructured":"Ahn S-C, Kim G-Y, Kim J-H, Baik S-W, Han M-K, Lee H-J, Moon D-O, Lee C-M, Kang J-H, Kim B-H (2004) Epigallocatechin-3-gallate, constituent of green tea, suppresses the LPS-induced phenotypic and functional maturation of murine dendritic cells through inhibition of mitogen-activated protein kinases and NF-\u039ab. Biochem Biophys Res Commun 313:148\u2013155","journal-title":"Biochem Biophys Res Commun"},{"key":"1731_CR3","doi-asserted-by":"publisher","first-page":"7","DOI":"10.4110\/in.2014.14.1.7","volume":"14","author":"J Alam","year":"2014","unstructured":"Alam J, Kim YC, Choi Y (2014) Potential role of bacterial infection in autoimmune diseases: a new aspect of molecular mimicry. Immune Network 14:7\u201313","journal-title":"Immune Network"},{"key":"1731_CR4","doi-asserted-by":"publisher","first-page":"3702","DOI":"10.1002\/art.30634","volume":"63","author":"D Aletaha","year":"2011","unstructured":"Aletaha D, Smolen JS (2011) Joint damage in rheumatoid arthritis progresses in remission according to the disease activity score in 28 joints and is driven by residual swollen joints. Arthritis Rheum 63:3702\u20133711","journal-title":"Arthritis Rheum"},{"key":"1731_CR5","doi-asserted-by":"publisher","first-page":"733","DOI":"10.1136\/ard.2010.138693","volume":"70","author":"D Aletaha","year":"2011","unstructured":"Aletaha D, Funovits J, Smolen JS (2011) Physical disability in rheumatoid arthritis is associated with cartilage damage rather than bone destruction. Ann Rheum Dis 70:733\u2013739","journal-title":"Ann Rheum Dis"},{"key":"1731_CR6","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s13075-015-0736-9","volume":"17","author":"D Aletaha","year":"2015","unstructured":"Aletaha D, Alasti F, Smolen JS (2015) Rheumatoid factor, not antibodies against citrullinated proteins, is associated with baseline disease activity in rheumatoid arthritis clinical trials. Arthritis Res Ther 17:1\u201310","journal-title":"Arthritis Res Ther"},{"key":"1731_CR7","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1002\/mnfr.201300195","volume":"58","author":"VBO Ayissi","year":"2014","unstructured":"Ayissi VBO, Ebrahimi A, Schluesenner H (2014) Epigenetic effects of natural polyphenols: a focus on Sirt1-mediated mechanisms. Mol Nutr Food Res 58:22\u201332","journal-title":"Mol Nutr Food Res"},{"key":"1731_CR8","doi-asserted-by":"publisher","first-page":"1586","DOI":"10.1056\/NEJM200011303432201","volume":"343","author":"JM Bathon","year":"2000","unstructured":"Bathon JM, Martin RW, Fleischmann RM, Tesser JR, Schiff MH, Keystone EC, Genovese MC, Wasko MC, Moreland LW, Weaver AL (2000) A comparison of etanercept and methotrexate in patients with early rheumatoid arthritis. N Engl J Med 343:1586\u20131593","journal-title":"N Engl J Med"},{"key":"1731_CR9","doi-asserted-by":"publisher","first-page":"5372","DOI":"10.1080\/10408398.2021.1924613","volume":"62","author":"T Behl","year":"2022","unstructured":"Behl T, Mehta K, Sehgal A, Singh S, Sharma N, Ahmadi A, Arora S, Bungau S (2022) Exploring the role of polyphenols in rheumatoid arthritis. Crit Rev Food Sci Nutr 62:5372\u20135393","journal-title":"Crit Rev Food Sci Nutr"},{"key":"1731_CR10","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1016\/j.tifs.2018.01.014","volume":"74","author":"T Belwal","year":"2018","unstructured":"Belwal T, Devkota HP, Hassan HA, Ahluwalia S, Ramadan MF, Mocan A, Atanasov AG (2018) Phytopharmacology of acerola (Malpighia Spp.) and its potential as functional food. Trends Food Sci Technol 74:99\u2013106","journal-title":"Trends Food Sci Technol"},{"key":"1731_CR11","doi-asserted-by":"crossref","unstructured":"Bharadwaj S, Sarma P (2020) Symptomization of rheumatoid arthritis in patients on pathological examination: a case study. 2020 IEEE international students' conference on electrical, electronics and computer science (Sceecs), IEEE, 1\u20133.","DOI":"10.1109\/SCEECS48394.2020.29"},{"key":"1731_CR12","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1016\/S0006-2952(99)00296-8","volume":"59","author":"ALA BowieO\u2019neill","year":"2000","unstructured":"BowieO\u2019neill ALA (2000) Oxidative stress and nuclear factor-\u039ab activation: a reassessment of the evidence in the light of recent discoveries. Biochem Pharmacol 59:13\u201323","journal-title":"Biochem Pharmacol"},{"key":"1731_CR13","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1007\/s40495-015-0018-x","volume":"1","author":"SS Boyanapalli","year":"2015","unstructured":"Boyanapalli SS, Kong A-NT (2015) \u201cCurcumin, The King Of Spices\u201d: epigenetic regulatory mechanisms in the prevention of cancer, neurological, and inflammatory diseases. Curr Pharmacol Rep 1:129\u2013139","journal-title":"Curr Pharmacol Rep"},{"key":"1731_CR14","doi-asserted-by":"publisher","first-page":"38050","DOI":"10.1074\/jbc.M112.377028","volume":"287","author":"F Busch","year":"2012","unstructured":"Busch F, Mobasheri A, Shayan P, Lueders C, Stahlmann R, Shakibaei M (2012) Resveratrol modulates interleukin-1\u03b2-induced phosphatidylinositol 3-kinase and nuclear factor \u039ab signaling pathways in human tenocytes. J Biol Chem 287:38050\u201338063","journal-title":"J Biol Chem"},{"key":"1731_CR15","doi-asserted-by":"publisher","first-page":"461","DOI":"10.1111\/j.1471-4159.2011.07594.x","volume":"120","author":"H Capiralla","year":"2012","unstructured":"Capiralla H, Vingtdeux V, Zhao H, Sankowski R, Al-Abed Y, Davies P, Marambaud P (2012) Resveratrol mitigates lipopolysaccharide-and A\u03b2-mediated microglial inflammation by inhibiting the Tlr4\/Nf-\u039ab\/Stat signaling cascade. J Neurochem 120:461\u2013472","journal-title":"J Neurochem"},{"key":"1731_CR16","doi-asserted-by":"publisher","first-page":"1719","DOI":"10.1002\/ptr.4639","volume":"26","author":"B Chandran","year":"2012","unstructured":"Chandran B, Goel A (2012) A randomized, pilot study to assess the efficacy and safety of curcumin in patients with active rheumatoid arthritis. Phytother Res 26:1719\u20131725","journal-title":"Phytother Res"},{"key":"1731_CR122","doi-asserted-by":"publisher","first-page":"2090","DOI":"10.3390\/molecules26072090","volume":"26","author":"HF Chiu","year":"2021","unstructured":"Chiu HF, Venkatakrishnan K, Golovinskaia O, Wang CK (2021) Gastroprotective effects of polyphenols against various gastro-intestinal disorders: a mini-review with special focus on clinical evidence. Mol 26: 2090","journal-title":"Mol"},{"key":"1731_CR17","doi-asserted-by":"publisher","DOI":"10.1016\/j.jff.2020.104003","volume":"71","author":"LM Christman","year":"2020","unstructured":"Christman LM, Gu L (2020) Efficacy and mechanisms of dietary polyphenols in mitigating rheumatoid arthritis. J Funct Foods 71:104003","journal-title":"J Funct Foods"},{"key":"1731_CR18","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/ar4174","volume":"15","author":"LJ Crofford","year":"2013","unstructured":"Crofford LJ (2013) Use of NSAIDS in treating patients with arthritis. Arthritis Res Ther 15:1\u201310","journal-title":"Arthritis Res Ther"},{"key":"1731_CR19","first-page":"348","volume":"43","author":"M D\u2019Archivio","year":"2007","unstructured":"D\u2019Archivio M, Filesi C, Di Benedetto R, Gargiulo R, Giovannini C, Masella R (2007) Polyphenols, dietary sources and bioavailability. Ann-Ist Superi Sanita 43:348","journal-title":"Ann-Ist Superi Sanita"},{"key":"1731_CR20","doi-asserted-by":"publisher","first-page":"348","DOI":"10.1681\/ASN.2016040449","volume":"28","author":"K Dahan","year":"2017","unstructured":"Dahan K, Debiec H, Plaisier E, Cachanado M, Rousseau A, Wakselman L, Michel P-A, Mihout F, Dussol B, Matignon M (2017) Rituximab for severe membranous nephropathy: a 6-month trial with extended follow-up. J Am Soc Nephrol 28:348\u2013358","journal-title":"J Am Soc Nephrol"},{"key":"1731_CR21","doi-asserted-by":"publisher","first-page":"520","DOI":"10.1097\/BOR.0b013e32832e6eaa","volume":"21","author":"J Dekker","year":"2009","unstructured":"Dekker J, Van Dijk GM, Veenhof C (2009) Risk factors for functional decline in osteoarthritis of the hip or knee. Curr Opin Rheumatol 21:520\u2013524","journal-title":"Curr Opin Rheumatol"},{"key":"1731_CR22","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/1264074","author":"S Ding","year":"2018","unstructured":"Ding S, Jiang H, Fang J (2018) Regulation of immune function by polyphenols. J Immunol Res. https:\/\/doi.org\/10.1155\/2018\/1264074","journal-title":"J Immunol Res"},{"key":"1731_CR23","doi-asserted-by":"publisher","first-page":"145","DOI":"10.3390\/pharmaceutics13020145","volume":"13","author":"R Direito","year":"2021","unstructured":"Direito R, Rocha J, Sepodes B, Eduardo-Figueira M (2021) Phenolic compounds impact on rheumatoid arthritis, inflammatory bowel disease and microbiota modulation. Pharmaceutics 13:145","journal-title":"Pharmaceutics"},{"key":"1731_CR24","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1038\/nrrheum.2017.204","volume":"14","author":"HJ Donahue","year":"2018","unstructured":"Donahue HJ, Qu RW, Genetos DC (2018) Joint diseases: from connexins to gap junctions. Nat Rev Rheumatol 14:42\u201351","journal-title":"Nat Rev Rheumatol"},{"key":"1731_CR25","doi-asserted-by":"publisher","first-page":"844","DOI":"10.1016\/j.autrev.2012.02.019","volume":"11","author":"W Dong","year":"2012","unstructured":"Dong W, Zhu P (2012) Functional niche of inflamed synovium for Th17-cell expansion and activation in rheumatoid arthritis: implication to clinical therapeutics. Autoimmun Rev 11:844\u2013851","journal-title":"Autoimmun Rev"},{"key":"1731_CR26","doi-asserted-by":"publisher","first-page":"1071","DOI":"10.1007\/s00702-009-0268-z","volume":"116","author":"A Dreiseitel","year":"2009","unstructured":"Dreiseitel A, Korte G, Schreier P, Oehme A, Locher S, Hajak G, Sand PG (2009) Sphospholipase A2 is inhibited by anthocyanidins. J Neural Transm 116:1071\u20131077","journal-title":"J Neural Transm"},{"key":"1731_CR119","doi-asserted-by":"publisher","first-page":"98","DOI":"10.2174\/1871530317666171114122417","volume":"18","author":"SA Fazal","year":"2018","unstructured":"Fazal SA, Khan M, Nishi SE, Alam F, Zarin N, Bari MT, Ashraf GM (2018) A clinical update and global economic burden of rheumatoid arthritis. Endocrine, metabolic & immune disorders-drug targets 18: 98\u2013109","journal-title":"Endocr Metab Immune Disord Drug Targets"},{"key":"1731_CR27","doi-asserted-by":"publisher","first-page":"351","DOI":"10.1021\/np050327j","volume":"69","author":"JL Funk","year":"2006","unstructured":"Funk JL, Oyarzo JN, Frye JB, Chen G, Lantz RC, Jolad SD, S\u00f3lyom AM, Timmermann BN (2006) Turmeric extracts containing curcuminoids prevent experimental rheumatoid arthritis. J Nat Prod 69:351\u2013355","journal-title":"J Nat Prod"},{"key":"1731_CR28","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1016\/S0889-857X(05)70201-5","volume":"27","author":"SE Gabriel","year":"2001","unstructured":"Gabriel SE (2001) The epidemiology of rheumatoid arthritis. Rheum Dis Clin North Am 27:269\u2013281","journal-title":"Rheum Dis Clin North Am"},{"key":"1731_CR29","doi-asserted-by":"publisher","first-page":"455","DOI":"10.3390\/nu9050455","volume":"9","author":"K Ganesan","year":"2017","unstructured":"Ganesan K, Xu B (2017) A critical review on polyphenols and health benefits of black soybeans. Nutrients 9:455","journal-title":"Nutrients"},{"key":"1731_CR30","doi-asserted-by":"publisher","first-page":"1205","DOI":"10.1002\/art.1780301102","volume":"30","author":"P Gregersen","year":"1987","unstructured":"Gregersen P, Silver J, Winchester RJ (1987) The shared epitope hypothesis: an approach to understanding the molecular genetics of susceptibility to rheumatoid arthritis. Arthritis Rheum 30:1205\u20131213","journal-title":"Arthritis Rheum"},{"key":"1731_CR31","doi-asserted-by":"publisher","first-page":"1432","DOI":"10.1248\/bpb.34.1432","volume":"34","author":"M-K Ha","year":"2011","unstructured":"Ha M-K, Song YH, Jeong S-J, Lee H-J, Jung JH, Kim B, Song HS, Huh J-E, Kim S-H (2011) Emodin inhibits proinflammatory responses and inactivates histone deacetylase 1 in hypoxic rheumatoid synoviocytes. Biol Pharm Bull 34:1432\u20131437","journal-title":"Biol Pharm Bull"},{"key":"1731_CR32","doi-asserted-by":"publisher","first-page":"5668","DOI":"10.1021\/acs.jafc.7b01879","volume":"65","author":"Y He","year":"2017","unstructured":"He Y, Zeng H, Yu Y, Zhang J, Zeng X, Gong F, Duan X, Liu Q, Yang B (2017) Resveratrol improved the progression of chronic prostatitis via the downregulation of C-Kit\/Scf by activating Sirt1. J Agric Food Chem 65:5668\u20135673","journal-title":"J Agric Food Chem"},{"key":"1731_CR33","doi-asserted-by":"publisher","first-page":"210","DOI":"10.1016\/j.taap.2011.12.025","volume":"259","author":"K-S Hong","year":"2012","unstructured":"Hong K-S, Park J-I, Kim M-J, Kim H-B, Lee J-W, Dao TT, Oh WK, Kang C-D, Kim S-H (2012) Involvement of Sirt1 in hypoxic down-regulation of C-Myc and \u0392-catenin and hypoxic preconditioning effect of polyphenols. Toxicol Appl Pharmacol 259:210\u2013218","journal-title":"Toxicol Appl Pharmacol"},{"key":"1731_CR34","doi-asserted-by":"publisher","first-page":"3601","DOI":"10.1080\/10408398.2016.1246413","volume":"57","author":"SD Hughes","year":"2017","unstructured":"Hughes SD, Ketheesan N, Haleagrahara N (2017) The therapeutic potential of plant flavonoids on rheumatoid arthritis. Crit Rev Food Sci Nutr 57:3601\u20133613","journal-title":"Crit Rev Food Sci Nutr"},{"key":"1731_CR35","doi-asserted-by":"publisher","first-page":"1583","DOI":"10.1093\/rheumatology\/ket178","volume":"52","author":"J-K Hwang","year":"2013","unstructured":"Hwang J-K, Noh E-M, Moon S-J, Kim J-M, Kwon K-B, Park B-H, You Y-O, Hwang B-M, Kim H-J, Kim B-S (2013) Emodin suppresses inflammatory responses and joint destruction in collagen-induced arthritic mice. Rheumatology 52:1583\u20131591","journal-title":"Rheumatology"},{"key":"1731_CR36","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/5137431","author":"M Islam","year":"2016","unstructured":"Islam M, Alam F, Solayman M, Khalil M, Kamal MA, Gan SH (2016) Dietary phytochemicals: natural swords combating inflammation and oxidation-mediated degenerative diseases. Oxid Med Cell Longev. https:\/\/doi.org\/10.1155\/2016\/5137431","journal-title":"Oxid Med Cell Longev"},{"key":"1731_CR37","doi-asserted-by":"publisher","first-page":"E90972","DOI":"10.1371\/journal.pone.0090972","volume":"9","author":"L Karthik","year":"2014","unstructured":"Karthik L, Kumar G, Keswani T, Bhattacharyya A, Chandar SS, Bhaskara Rao K (2014) Protease inhibitors from marine actinobacteria as a potential source for antimalarial compound. PLoS ONE 9:E90972","journal-title":"PLoS ONE"},{"key":"1731_CR38","doi-asserted-by":"publisher","first-page":"647","DOI":"10.1016\/j.autrev.2019.05.001","volume":"18","author":"H Khan","year":"2019","unstructured":"Khan H, Sureda A, Belwal T, \u00c7etinkaya S, S\u00fcntar \u0130, Tejada S, Devkota HP, Ullah H, Aschner M (2019) Polyphenols in the treatment of autoimmune diseases. Autoimmun Rev 18:647\u2013657","journal-title":"Autoimmun Rev"},{"key":"1731_CR39","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1007\/s10067-016-3485-5","volume":"36","author":"M Kihara","year":"2017","unstructured":"Kihara M, Davies R, Kearsley-Fleet L, Watson KD, Lunt M, Symmons DP, Hyrich KL (2017) Use and effectiveness of tocilizumab among patients with rheumatoid arthritis: an observational study from the british society for rheumatology biologics register for rheumatoid arthritis. Clin Rheumatol 36:241\u2013250","journal-title":"Clin Rheumatol"},{"key":"1731_CR40","doi-asserted-by":"publisher","first-page":"396","DOI":"10.1016\/j.bbadis.2009.12.009","volume":"1802","author":"EK Kim","year":"2010","unstructured":"Kim EK, Choi E-J (2010) Pathological roles of Mapk signaling pathways in human diseases. Biochimica Biophys Acta (Bba)-Mol Basis Dis 1802:396\u2013405","journal-title":"Biochimica Biophys Acta (Bba)-Mol Basis Dis"},{"key":"1731_CR41","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1016\/j.cyto.2017.04.012","volume":"98","author":"EY Kim","year":"2017","unstructured":"Kim EY, Moudgil KD (2017) Immunomodulation of autoimmune arthritis by pro-inflammatory cytokines. Cytokine 98:87\u201396","journal-title":"Cytokine"},{"key":"1731_CR42","doi-asserted-by":"publisher","DOI":"10.1254\/jphs.crj04003x","author":"HP Kim","year":"2004","unstructured":"Kim HP, Son KH, Chang HW, Kang SS (2004) Anti-inflammatory plant flavonoids and cellular action mechanisms. J Pharmacolo Sci. https:\/\/doi.org\/10.1254\/jphs.crj04003x","journal-title":"J Pharmacolo Sci"},{"key":"1731_CR43","doi-asserted-by":"publisher","first-page":"400","DOI":"10.1016\/j.intimp.2013.01.003","volume":"15","author":"B Kloesch","year":"2013","unstructured":"Kloesch B, Becker T, Dietersdorfer E, Kiener H, Steiner G (2013) Anti-inflammatory and apoptotic effects of the polyphenol curcumin on human fibroblast-like synoviocytes. Int Immunopharmacol 15:400\u2013405","journal-title":"Int Immunopharmacol"},{"key":"1731_CR44","doi-asserted-by":"publisher","first-page":"581","DOI":"10.1016\/j.molonc.2014.01.005","volume":"8","author":"E Kronski","year":"2014","unstructured":"Kronski E, Fiori ME, Barbieri O, Astigiano S, Mirisola V, Killian PH, Bruno A, Pagani A, Rovera F, Pfeffer U (2014) Mir181b is induced by the chemopreventive polyphenol curcumin and inhibits breast cancer metastasis via down-regulation of the inflammatory cytokines Cxcl1 and-2. Mol Oncol 8:581\u2013595","journal-title":"Mol Oncol"},{"key":"1731_CR45","doi-asserted-by":"publisher","first-page":"473","DOI":"10.1007\/s10822-007-9129-8","volume":"21","author":"J L\u00e4ttig","year":"2007","unstructured":"L\u00e4ttig J, B\u00f6hl M, Fischer P, Tischer S, Tietb\u00f6hl C, Menschikowski M, Gutzeit HO, Metz P, Pisabarro MT (2007) Mechanism of inhibition of human secretory phospholipase A2 by flavonoids: rationale for lead design. J Comput Aided Mol des 21:473\u2013483","journal-title":"J Comput Aided Mol des"},{"key":"1731_CR46","doi-asserted-by":"publisher","first-page":"51251","DOI":"10.1002\/app.51251","volume":"138","author":"Y Lei","year":"2021","unstructured":"Lei Y, Mao L, Zhu H, Yao J (2021) Development of catechol-functionalized chitosan\/poly (vinyl alcohol) nanocomposite films incorporated with dual network coated layered clay for active packaging applications. J Appl Polym Sci 138:51251","journal-title":"J Appl Polym Sci"},{"key":"1731_CR47","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1007\/s11010-013-1728-1","volume":"382","author":"H Li","year":"2013","unstructured":"Li H, Jia Z, Li A, Jenkins G, Yang X, Hu J, Guo W (2013) Resveratrol repressed viability of U251 cells by Mir-21 inhibiting of Nf-\u039ab pathway. Mol Cell Biochem 382:137\u2013143","journal-title":"Mol Cell Biochem"},{"key":"1731_CR48","doi-asserted-by":"publisher","first-page":"315","DOI":"10.2147\/DDDT.S52354","volume":"8","author":"J Li","year":"2014","unstructured":"Li J, Li J, Yue Y, Hu Y, Cheng W, Liu R, Pan X, Zhang P (2014) Genistein suppresses tumor necrosis factor \u0391-induced inflammation via modulating reactive oxygen species\/Akt\/nuclear factor \u039ab and adenosine monophosphate-activated protein kinase signal pathways in human synoviocyte Mh7a cells. Drug des Dev Ther 8:315","journal-title":"Drug des Dev Ther"},{"key":"1731_CR49","doi-asserted-by":"publisher","first-page":"324","DOI":"10.1111\/1753-0407.12296","volume":"8","author":"Z Liu","year":"2016","unstructured":"Liu Z, Jiang C, Zhang J, Liu B, Du Q (2016) Resveratrol inhibits inflammation and ameliorates insulin resistant endothelial dysfunction via regulation of amp-activated protein kinase and sirtuin 1 activities. J Diabetes 8:324\u2013335","journal-title":"J Diabetes"},{"key":"1731_CR50","first-page":"E17023","volume":"2","author":"T Liu","year":"2017","unstructured":"Liu T, Zhang L, Joo D, Sun S (2017) Signal transduct. Target Ther 2:E17023","journal-title":"Target Ther"},{"key":"1731_CR51","first-page":"2479","volume":"17","author":"Z Lou","year":"2018","unstructured":"Lou Z, Li X, Zhao X, Du K, Li X, Wang B (2018) Resveratrol attenuates hydrogen peroxide-induced apoptosis, reactive oxygen species generation, and Psgl-1 and Vwf activation in human umbilical vein endothelial cells, potentially via Mapk signalling pathways. Mol Med Rep 17:2479\u20132487","journal-title":"Mol Med Rep"},{"key":"1731_CR52","doi-asserted-by":"publisher","first-page":"991","DOI":"10.1016\/j.bbrc.2007.06.002","volume":"359","author":"Z Lu","year":"2007","unstructured":"Lu Z, Doulabi BZ, Wuisman P, Bank R, Helder M (2007) Differentiation of adipose stem cells by nucleus pulposus cells: configuration effect. Biochem Biophys Res Commun 359:991\u2013996","journal-title":"Biochem Biophys Res Commun"},{"key":"1731_CR53","doi-asserted-by":"publisher","first-page":"35","DOI":"10.3390\/antiox9010035","volume":"9","author":"T Magrone","year":"2019","unstructured":"Magrone T, Magrone M, Russo MA, Jirillo E (2019) Recent advances on the anti-inflammatory and antioxidant properties of red grape polyphenols: in vitro and in vivo studies. Antioxidants 9:35","journal-title":"Antioxidants"},{"key":"1731_CR54","doi-asserted-by":"publisher","first-page":"327","DOI":"10.1089\/ars.2012.4600","volume":"17","author":"S Malireddy","year":"2012","unstructured":"Malireddy S, Kotha SR, Secor JD, Gurney TO, Abbott JL, Maulik G, Maddipati KR, Parinandi NL (2012) Phytochemical antioxidants modulate mammalian cellular epigenome: implications in health and disease. Antioxid Redox Signal 17:327\u2013339","journal-title":"Antioxid Redox Signal"},{"key":"1731_CR55","doi-asserted-by":"publisher","first-page":"1156","DOI":"10.1126\/science.aar7201","volume":"359","author":"S Manfredo Vieira","year":"2018","unstructured":"Manfredo Vieira S, Hiltensperger M, Kumar V, Zegarra-Ruiz D, Dehner C, Khan N, Costa F, Tiniakou E, Greiling T, Ruff W (2018) Translocation Of a gut pathobiont drives autoimmunity in mice and humans. Science 359:1156\u20131161","journal-title":"Science"},{"key":"1731_CR56","doi-asserted-by":"publisher","first-page":"436","DOI":"10.1038\/nature07205","volume":"454","author":"A Mantovani","year":"2008","unstructured":"Mantovani A, Allavena P, Sica A, Balkwill F (2008) Cancer-related inflammation. Nature 454:436\u2013444","journal-title":"Nature"},{"key":"1731_CR57","doi-asserted-by":"publisher","first-page":"2118","DOI":"10.3390\/ijms19072118","volume":"19","author":"A Maugeri","year":"2018","unstructured":"Maugeri A, Barchitta M, Mazzone MG, Giuliano F, Basile G, Agodi A (2018) Resveratrol modulates Sirt1 and DNMT functions and restores Line-1 methylation levels in ARPE-19 cells under oxidative stress and inflammation. Int J Mol Sci 19:2118","journal-title":"Int J Mol Sci"},{"key":"1731_CR58","doi-asserted-by":"publisher","first-page":"2205","DOI":"10.1056\/NEJMra1004965","volume":"365","author":"IB Mcinnes","year":"2011","unstructured":"Mcinnes IB, Schett G (2011) The pathogenesis of rheumatoid arthritis. N Engl J Med 365:2205\u20132219","journal-title":"N Engl J Med"},{"key":"1731_CR59","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s12950-015-0097-9","volume":"12","author":"S-Y Min","year":"2015","unstructured":"Min S-Y, Yan M, Kim SB, Ravikumar S, Kwon S-R, Vanarsa K, Kim H-Y, Davis LS, Mohan C (2015) Green tea epigallocatechin-3-gallate suppresses autoimmune arthritis through indoleamine-2, 3-dioxygenase expressing dendritic cells and the nuclear factor, erythroid 2-like 2 antioxidant pathway. J Inflamm 12:1\u201315","journal-title":"J Inflamm"},{"key":"1731_CR60","doi-asserted-by":"publisher","first-page":"2012","DOI":"10.1002\/art.23594","volume":"58","author":"A Morinobu","year":"2008","unstructured":"Morinobu A, Biao W, Tanaka S, Horiuchi M, Jun L, Tsuji G, Sakai Y, Kurosaka M, Kumagai S (2008) (\u2212)-Epigallocatechin-3-gallate suppresses osteoclast differentiation and ameliorates experimental arthritis in mice. Arthritis Rheum 58:2012\u20132018","journal-title":"Arthritis Rheum"},{"key":"1731_CR61","doi-asserted-by":"publisher","first-page":"945","DOI":"10.2174\/138955706777934937","volume":"6","author":"N-H Nam","year":"2006","unstructured":"Nam N-H (2006) Naturally occurring Nf-\u039ab inhibitors. Mini Rev Med Chem 6:945\u2013951","journal-title":"Mini Rev Med Chem"},{"key":"1731_CR62","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1097\/BOR.0b013e3282fb7caa","volume":"20","author":"P Nandi","year":"2008","unstructured":"Nandi P, Kingsley GH, Scott DL (2008) Disease-modifying antirheumatic drugs other than methotrexate in rheumatoid arthritis and seronegative arthritis. Curr Opin Rheumatol 20:251\u2013256","journal-title":"Curr Opin Rheumatol"},{"key":"1731_CR63","doi-asserted-by":"publisher","first-page":"E0127165","DOI":"10.1371\/journal.pone.0127165","volume":"10","author":"V Natarajan","year":"2015","unstructured":"Natarajan V, Madhan B, Tiku ML (2015) Intra-articular injections of polyphenols protect articular cartilage from inflammation-induced degradation: suggesting a potential role in cartilage therapeutics. PLoS ONE 10:E0127165","journal-title":"PLoS ONE"},{"key":"1731_CR120","doi-asserted-by":"publisher","first-page":"e260","DOI":"10.1016\/j.atherosclerosis.2019.06.803","volume":"287","author":"V Nemtsova","year":"2019","unstructured":"Nemtsova V, Bilovol O, Zlatkina V, Ilchenko I (2019) The effect of middle-dose statin therapy on the vascular endothelium function in patients with a combined course of hypertension, type 2 diabetes and subclinical hypothyroidism. Atherosclerosis 287: e260","journal-title":"Atherosclerosis"},{"key":"1731_CR64","doi-asserted-by":"publisher","first-page":"1389","DOI":"10.1136\/ard.2009.119776","volume":"69","author":"C Ng","year":"2010","unstructured":"Ng C, Biniecka M, Kennedy A, Mccormick J, Fitzgerald O, Bresnihan B, Buggy D, Taylor C, O\u2019sullivan J, Fearon U (2010) Synovial tissue hypoxia and inflammation in vivo. Ann Rheum Dis 69:1389\u20131395","journal-title":"Ann Rheum Dis"},{"key":"1731_CR65","doi-asserted-by":"publisher","first-page":"68","DOI":"10.2174\/1573397115666191127141801","volume":"17","author":"P Nijhawan","year":"2021","unstructured":"Nijhawan P, Behl T (2021) The role of endostatin in rheumatoid arthritis. Curr Rheumatol Rev 17:68\u201375","journal-title":"Curr Rheumatol Rev"},{"key":"1731_CR66","doi-asserted-by":"publisher","first-page":"1306","DOI":"10.3390\/nu9121306","volume":"9","author":"ALDB Oliveira","year":"2017","unstructured":"Oliveira ALDB, Monteiro VVS, Navegantes-Lima KC, Reis JF, Gomes RDS, Rodrigues DVS, Gaspar SLDF, Monteiro MC (2017) Resveratrol Role in autoimmune disease\u2014a mini-review. Nutrients 9:1306","journal-title":"Nutrients"},{"key":"1731_CR67","doi-asserted-by":"publisher","first-page":"1653","DOI":"10.1002\/jsfa.8664","volume":"98","author":"F Oliviero","year":"2018","unstructured":"Oliviero F, Scanu A, Zamudio-Cuevas Y, Punzi L, Spinella P (2018) Anti-Inflammatory effects of polyphenols in arthritis. J Sci Food Agric 98:1653\u20131659","journal-title":"J Sci Food Agric"},{"issue":"11","key":"1731_CR68","doi-asserted-by":"publisher","first-page":"1465","DOI":"10.2174\/138161212799504740","volume":"18","author":"A Onat","year":"2012","unstructured":"Onat A, Direskeneli H (2012) Excess cardiovascular risk in inflammatory rheumatic diseases: pathophysiology and targeted therapy. Curr Pharm des 18(11):1465\u20131477","journal-title":"Curr Pharm des"},{"key":"1731_CR69","doi-asserted-by":"publisher","first-page":"463","DOI":"10.1038\/nrrheum.2017.115","volume":"13","author":"C Orr","year":"2017","unstructured":"Orr C, Vieira-Sousa E, Boyle DL, Buch MH, Buckley CD, Ca\u00f1ete JD, Catrina AI, Choy EH, Emery P, Fearon U (2017) Synovial tissue research: a state-of-the-art review. Nat Rev Rheumatol 13:463\u2013475","journal-title":"Nat Rev Rheumatol"},{"key":"1731_CR70","doi-asserted-by":"publisher","first-page":"409","DOI":"10.1007\/s00281-017-0621-5","volume":"39","author":"C Ospelt","year":"2017","unstructured":"Ospelt C, Gay S, Klein K (2017) Epigenetics in the pathogenesis of RA. Semin Immunopathol 39:409\u2013419","journal-title":"Semin Immunopathol"},{"key":"1731_CR71","first-page":"365","volume":"20","author":"C Park","year":"2007","unstructured":"Park C, Moon D-O, Choi I-W, Choi BT, Nam T-J, Rhu C-H, Kwon TK, Lee WH, Kim G-Y, Choi YH (2007) Curcumin induces apoptosis and inhibits prostaglandin E2 production in synovial fibroblasts of patients with rheumatoid arthritis. Int J Mol Med 20:365\u2013372","journal-title":"Int J Mol Med"},{"key":"1731_CR73","doi-asserted-by":"publisher","first-page":"2946","DOI":"10.1172\/JCI93450","volume":"127","author":"A Pianta","year":"2017","unstructured":"Pianta A, Arvikar SL, Strle K, Drouin EE, Wang Q, Costello CE, Steere AC (2017) Two rheumatoid arthritis-specific autoantigens correlate microbial immunity with autoimmune responses in joints. J Clin Investig 127:2946\u20132956","journal-title":"J Clin Investig"},{"key":"1731_CR121","doi-asserted-by":"publisher","first-page":"409","DOI":"10.46939\/J.Sci.Arts-24.2-b02","volume":"24","author":"CG Pisoschi","year":"2024","unstructured":"Pisoschi CG, Varut RM, Popescu C (2024) Molecular docking analysis and dynamics simulation of some antioxidant polyphenols. J Sci Arts 24: 409\u2013418","journal-title":"J Sci Arts"},{"key":"1731_CR74","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1159\/000314513","volume":"101","author":"I Rahman","year":"2010","unstructured":"Rahman I, Chung S (2010) Dietary polyphenols, deacetylases and chromatin remodeling in inflammation. Personalized Nutr 101:84\u201394","journal-title":"Personalized Nutr"},{"key":"1731_CR75","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1007\/s10753-010-9278-0","volume":"34","author":"G Ramadan","year":"2011","unstructured":"Ramadan G, Al-Kahtani MA, El-Sayed WM (2011) Anti-inflammatory and anti-oxidant properties of curcuma longa (turmeric) versus Zingiber officinale (Ginger) rhizomes in rat adjuvant-induced arthritis. Inflammation 34:291\u2013301","journal-title":"Inflammation"},{"key":"1731_CR76","doi-asserted-by":"publisher","first-page":"234","DOI":"10.1038\/nrd3669","volume":"11","author":"K Redlich","year":"2012","unstructured":"Redlich K, Smolen JS (2012) Inflammatory bone loss: pathogenesis and therapeutic intervention. Nat Rev Drug Discov 11:234\u2013250","journal-title":"Nat Rev Drug Discov"},{"key":"1731_CR77","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1016\/j.pharmthera.2018.09.009","volume":"194","author":"KR Rengasamy","year":"2019","unstructured":"Rengasamy KR, Khan H, Gowrishankar S, Lagoa RJ, Mahomoodally FM, Khan Z, Suroowan S, Tewari D, Zengin G, Hassan ST (2019) The role of flavonoids in autoimmune diseases: therapeutic updates. Pharmacol Ther 194:107\u2013131","journal-title":"Pharmacol Ther"},{"key":"1731_CR78","doi-asserted-by":"publisher","first-page":"1275","DOI":"10.1016\/j.jnutbio.2014.07.006","volume":"25","author":"M\u00c1 Rosillo","year":"2014","unstructured":"Rosillo M\u00c1, Alcaraz MJ, S\u00e1nchez-Hidalgo M, Fern\u00e1ndez-Bola\u00f1os JG, Alarc\u00f3n-De-La-Lastra C, Ferr\u00e1ndiz ML (2014) Anti-inflammatory and joint protective effects of extra-virgin olive-oil polyphenol extract in experimental arthritis. J Nutr Biochem 25:1275\u20131281","journal-title":"J Nutr Biochem"},{"key":"1731_CR79","doi-asserted-by":"publisher","first-page":"480","DOI":"10.1136\/annrheumdis-2014-206624","volume":"74","author":"C Roubille","year":"2015","unstructured":"Roubille C, Richer V, Starnino T, Mccourt C, Mcfarlane A, Fleming P, Siu S, Kraft J, Lynde C, Pope J (2015) The effects of tumour necrosis factor inhibitors, methotrexate, non-steroidal anti-inflammatory drugs and corticosteroids on cardiovascular events in rheumatoid arthritis, psoriasis and psoriatic arthritis: a systematic review and meta-analysis. Ann Rheum Dis 74:480\u2013489","journal-title":"Ann Rheum Dis"},{"key":"1731_CR80","first-page":"394","volume":"43","author":"C Santangelo","year":"2007","unstructured":"Santangelo C, Var\u00ec R, Scazzocchio B, Di Benedetto R, Filesi C, Masella R (2007) Polyphenols, intracellular signalling and inflammation. Annali-Istituto Superiore di Sanita 43:394","journal-title":"Annali-Istituto Superiore di Sanita"},{"key":"1731_CR81","doi-asserted-by":"publisher","first-page":"E01202","DOI":"10.7554\/eLife.01202","volume":"2","author":"JU Scher","year":"2013","unstructured":"Scher JU, Sczesnak A, Longman RS, Segata N, Ubeda C, Bielski C, Rostron T, Cerundolo V, Pamer EG, Abramson SB (2013) Expansion of intestinal prevotella copri correlates with enhanced susceptibility to arthritis. Elife 2:E01202","journal-title":"Elife"},{"key":"1731_CR82","doi-asserted-by":"publisher","first-page":"E01202","DOI":"10.7554\/eLife.01202","volume":"2","author":"S Scherju","year":"2013","unstructured":"Scherju S (2013) Expansion of intestinal Prevotella copri correlates with enhanced susceptibility to arthritis. Elife 2:E01202","journal-title":"Elife"},{"key":"1731_CR83","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/ar2571","volume":"11","author":"G Schett","year":"2009","unstructured":"Schett G (2009) Osteoimmunology in rheumatic diseases. Arthritis Res Ther 11:1\u20136","journal-title":"Arthritis Res Ther"},{"key":"1731_CR84","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1016\/j.bbapap.2014.12.017","volume":"1854","author":"PK Shukla","year":"2015","unstructured":"Shukla PK, Gautam L, Sinha M, Kaur P, Sharma S, Singh TP (2015) Structures and binding studies of the complexes of phospholipase A2 with five inhibitors. Biochimica Biophys Acta (Bba)-Proteins and Proteomics 1854:269\u2013277","journal-title":"Biochimica Biophys Acta (Bba)-Proteins and Proteomics"},{"key":"1731_CR85","doi-asserted-by":"publisher","first-page":"583","DOI":"10.1080\/10715762.2018.1455002","volume":"52","author":"E Simon","year":"2018","unstructured":"Simon E, Aswini P, Sameer Kumar V, Mankadath G (2018) Curcumin and its synthetic analogue dimethoxycurcumin differentially modulates antioxidant status of normal human peripheral blood mononuclear cells. Free Radical Res 52:583\u2013591","journal-title":"Free Radical Res"},{"key":"1731_CR86","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1016\/j.pathophys.2006.05.002","volume":"13","author":"U Singh","year":"2006","unstructured":"Singh U, Jialal I (2006) Oxidative stress and atherosclerosis. Pathophysiology 13:129\u2013142","journal-title":"Pathophysiology"},{"key":"1731_CR87","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD012657","author":"JA Singh","year":"2017","unstructured":"Singh JA, Hossain A, Mudano AS, Ghogomu ET, Suarez-Almazor ME, Buchbinder R, Maxwell LJ, Tugwell P, Wells GA (2017) Biologics or tofacitinib for people with rheumatoid arthritis naive to methotrexate: a systematic review and network meta-analysis. Cochrane Database Syst Rev. https:\/\/doi.org\/10.1002\/14651858.CD012657","journal-title":"Cochrane Database Syst Rev"},{"key":"1731_CR88","doi-asserted-by":"publisher","DOI":"10.1515\/mmr-2017-0002","author":"D Spasovski","year":"2017","unstructured":"Spasovski D, Genadieva-Stavric S, Sotirova T, Brezovska-Kavrakova J (2017) Rheumatoid Factor as a potentiator of anti-citrullinated protein antibody-mediated inflammation in early undifferentiated seronegative osteoarthropathy. Macedonian Med Rev. https:\/\/doi.org\/10.1515\/mmr-2017-0002","journal-title":"Macedonian Med Rev"},{"key":"1731_CR89","doi-asserted-by":"publisher","first-page":"311","DOI":"10.1677\/JOE-09-0270","volume":"204","author":"H-Z Sun","year":"2010","unstructured":"Sun H-Z, Yang T-W, Zang W-J, Wu S-F (2010) Dehydroepiandrosterone-induced proliferation of prostatic epithelial cell is mediated By Nfkb Via Pi3k\/Akt signaling pathway. J Endocrinol 204:311","journal-title":"J Endocrinol"},{"key":"1731_CR90","doi-asserted-by":"publisher","first-page":"1937","DOI":"10.1084\/jem.20160792","volume":"213","author":"EM Tan","year":"2016","unstructured":"Tan EM, Smolen JS (2016) Historical observations contributing insights on etiopathogenesis of rheumatoid arthritis and role of rheumatoid factor. J Exp Med 213:1937\u20131950","journal-title":"J Exp Med"},{"key":"1731_CR91","first-page":"9CMT.S282","volume":"5","author":"T Tanaka","year":"2013","unstructured":"Tanaka T, Ogata A, Narazaki M (2013) Tocilizumab: an updated review of its use in the treatment of rheumatoid arthritis and its application for other immune-mediated diseases. Clin Med Insights: Ther 5:9CMT.S282","journal-title":"Clin Med Insights: Ther"},{"key":"1731_CR117","doi-asserted-by":"publisher","first-page":"2825","DOI":"10.1038\/s41467-025-58186-7","volume":"16","author":"K Tanaka","year":"2025","unstructured":"Tanaka K, Sugisaka J, Shiraishi Y, Watanabe Y, Daga H, Azuma K, Nishino K, Mori M, Ota T, Saito H (2025) Serum vegf-a as a biomarker for the addition of bevacizumab to chemo-immunotherapy in metastatic nsclc. Nat commun 16:2825","journal-title":"Nat commun"},{"issue":"7","key":"1731_CR118","doi-asserted-by":"publisher","first-page":"1829","DOI":"10.1007\/s00296-012-2657-0","volume":"33","author":"J Tian","year":"2013","unstructured":"Tian J, Chen J, Gao J, Li L,  Xie X (2013) Resveratrol inhibits TNF-\u03b1-induced IL-1\u03b2 MMP-3 production in human rheumatoid arthritis fibroblast-like synoviocytes via modulation of PI3kinase\/Akt pathway. Rheumatol Int 33(7) 1829\u20131835. https:\/\/doi.org\/10.1007\/s00296-012-2657-0","journal-title":"Rheumatol Int"},{"key":"1731_CR94","doi-asserted-by":"publisher","first-page":"3729","DOI":"10.1002\/art.20590","volume":"50","author":"C Turesson","year":"2004","unstructured":"Turesson C, Mcclelland RL, Christianson TJ, Matteson EL (2004) No decrease over time in the incidence of vasculitis or other extraarticular manifestations in rheumatoid arthritis: results from a community-based study. Arthritis Rheum 50:3729\u20133731","journal-title":"Arthritis Rheum"},{"key":"1731_CR95","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.01363.2007","author":"K Venkatachalam","year":"2008","unstructured":"Venkatachalam K, Mummidi S, Cortez DM, Prabhu SD, Valente AJ, Chandrasekar B (2008) Resveratrol inhibits high glucose-induced Pi3k\/Akt\/Erk-dependent interleukin-17 expression in primary mouse cardiac fibroblasts. Am J Physiol-Heart Circulatory Physiol. https:\/\/doi.org\/10.1152\/ajpheart.01363.2007","journal-title":"Am J Physiol-Heart Circulatory Physiol"},{"key":"1731_CR96","doi-asserted-by":"publisher","first-page":"341","DOI":"10.1007\/s00011-003-1182-8","volume":"52","author":"M Verdrengh","year":"2003","unstructured":"Verdrengh M, Jonsson I, Holmdahl R, Tarkowski A (2003) Genistein as an anti-inflammatory agent. Inflamm Res 52:341\u2013346","journal-title":"Inflamm Res"},{"key":"1731_CR97","doi-asserted-by":"publisher","first-page":"395","DOI":"10.1007\/s00281-017-0630-4","volume":"39","author":"S Viatte","year":"2017","unstructured":"Viatte S, Barton A (2017) Genetics Of rheumatoid arthritis susceptibility, severity, and treatment response. Semin Immunopathol 39:395\u2013408","journal-title":"Semin Immunopathol"},{"key":"1731_CR98","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1038\/nrrheum.2012.237","volume":"9","author":"S Viatte","year":"2013","unstructured":"Viatte S, Plant D, Raychaudhuri S (2013) Genetics and epigenetics of rheumatoid arthritis. Nat Rev Rheumatol 9:141\u2013153","journal-title":"Nat Rev Rheumatol"},{"key":"1731_CR99","doi-asserted-by":"publisher","first-page":"963","DOI":"10.1016\/S0006-2952(01)00734-1","volume":"62","author":"TL Wadsworth","year":"2001","unstructured":"Wadsworth TL, Mcdonald TL, Koop DR (2001) Effects of ginkgo biloba extract (Egb 761) and quercetin on lipopolysaccharide-induced signaling pathways involved in the release of tumor necrosis factor-\u0391. Biochem Pharmacol 62:963\u2013974","journal-title":"Biochem Pharmacol"},{"key":"1731_CR100","doi-asserted-by":"publisher","first-page":"1705","DOI":"10.3109\/13880209.2015.1125931","volume":"54","author":"MG Wahba","year":"2016","unstructured":"Wahba MG, Messiha BA, Abo-Saif AA (2016) Protective effects of fenofibrate and resveratrol in an aggressive model of rheumatoid arthritis in rats. Pharm Biol 54:1705\u20131715","journal-title":"Pharm Biol"},{"key":"1731_CR101","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1016\/j.semcdb.2015.10.014","volume":"50","author":"D Wallach","year":"2016","unstructured":"Wallach D (2016) The cybernetics of tnf: old views and newer ones. Semin Cell Dev Biol 50:105\u2013114","journal-title":"Semin Cell Dev Biol"},{"key":"1731_CR102","doi-asserted-by":"publisher","first-page":"405","DOI":"10.1016\/j.maturitas.2008.04.003","volume":"59","author":"J Wang","year":"2008","unstructured":"Wang J, Zhang Q, Jin S, He D, Zhao S, Liu S (2008) Genistein modulate immune responses in collagen-induced rheumatoid arthritis model. Maturitas 59:405\u2013412","journal-title":"Maturitas"},{"key":"1731_CR103","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1016\/j.mam.2011.10.001","volume":"33","author":"D Wu","year":"2012","unstructured":"Wu D, Wang J, Pae M, Meydani SN (2012) Green tea Egcg, T cells, and T cell-mediated autoimmune diseases. Mol Aspects Med 33:107\u2013118","journal-title":"Mol Aspects Med"},{"key":"1731_CR104","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1136\/ard.2011.149831","volume":"71","author":"G Xuzhu","year":"2012","unstructured":"Xuzhu G, Komai-Koma M, Leung BP, Howe HS, Mcsharry C, Mcinnes IB, Xu D (2012) Resveratrol modulates murine collagen-induced arthritis by inhibiting Th17 and B-cell function. Ann Rheum Dis 71:129\u2013135","journal-title":"Ann Rheum Dis"},{"key":"1731_CR105","doi-asserted-by":"publisher","first-page":"1618","DOI":"10.3390\/nu10111618","volume":"10","author":"N Yahfoufi","year":"2018","unstructured":"Yahfoufi N, Alsadi N, Jambi M, Matar C (2018) The immunomodulatory and anti-inflammatory role of polyphenols. Nutrients 10:1618","journal-title":"Nutrients"},{"key":"1731_CR106","doi-asserted-by":"publisher","first-page":"12953","DOI":"10.1021\/acs.jafc.8b05047","volume":"66","author":"G Yang","year":"2018","unstructured":"Yang G, Chang C-C, Yang Y, Yuan L, Xu L, Ho C-T, Li S (2018) Resveratrol alleviates rheumatoid arthritis via reducing ROS and inflammation, inhibiting MAPK signaling pathways, and suppressing angiogenesis. J Agric Food Chem 66:12953\u201312960","journal-title":"J Agric Food Chem"},{"key":"1731_CR107","doi-asserted-by":"publisher","first-page":"2043","DOI":"10.1111\/bph.13803","volume":"174","author":"SCM Yeo","year":"2017","unstructured":"Yeo SCM, Fenwick PS, Barnes PJ, Lin HS, Donnelly LE (2017) Isorhapontigenin, a bioavailable dietary polyphenol, suppresses airway epithelial cell inflammation through a corticosteroid-independent mechanism. Br J Pharmacol 174:2043\u20132059","journal-title":"Br J Pharmacol"},{"key":"1731_CR108","first-page":"345","volume":"36","author":"AWK Yeung","year":"2018","unstructured":"Yeung AWK, Aggarwal BB, Barreca D, Battino M, Belwal T, Horbanczuk OK, Berindan-Neagoe I, Bishayee A, Daglia M, Devkota HP (2018) Dietary natural products and their potential to influence health and disease including animal model studies. Anim Sci Pap Rep 36:345\u2013358","journal-title":"Anim Sci Pap Rep"},{"key":"1731_CR109","doi-asserted-by":"publisher","first-page":"585","DOI":"10.3349\/ymj.2005.46.5.585","volume":"46","author":"J-H Yoon","year":"2005","unstructured":"Yoon J-H, Baek SJ (2005) Molecular targets of dietary polyphenols with anti-inflammatory properties. Yonsei Med J 46:585\u2013596","journal-title":"Yonsei Med J"},{"key":"1731_CR110","doi-asserted-by":"publisher","first-page":"971","DOI":"10.3892\/ijmm.2013.1468","volume":"32","author":"HY Yoon","year":"2013","unstructured":"Yoon HY, Lee EG, Lee H, Cho IJ, Choi YJ, Sung MS, Yoo HG, Yoo WH (2013) Kaempferol inhibits Il-1\u03b2-induced proliferation of rheumatoid arthritis synovial fibroblasts and the production Of Cox-2, Pge2 and Mmps. Int J Mol Med 32:971\u2013977","journal-title":"Int J Mol Med"},{"key":"1731_CR111","doi-asserted-by":"publisher","first-page":"637","DOI":"10.1002\/art.40406","volume":"70","author":"S You","year":"2018","unstructured":"You S, Koh JH, Leng L, Kim WU, Bucala R (2018) The tumor-like phenotype of rheumatoid synovium: molecular profiling and prospects for precision medicine. Arthritis Rheumatol 70:637\u2013652","journal-title":"Arthritis Rheumatol"},{"key":"1731_CR112","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1007\/s00296-008-0597-5","volume":"29","author":"H-J Yun","year":"2008","unstructured":"Yun H-J, Yoo W-H, Han M-K, Lee Y-R, Kim J-S, Lee S-I (2008) Epigallocatechin-3-gallate suppresses Tnf-A-induced production of Mmp-1 and-3 in rheumatoid arthritis synovial fibroblasts. Rheumatol Int 29:23\u201329","journal-title":"Rheumatol Int"},{"key":"1731_CR113","doi-asserted-by":"publisher","first-page":"377","DOI":"10.1007\/s10753-011-9365-x","volume":"35","author":"Y Zhang","year":"2012","unstructured":"Zhang Y, Dong J, He P, Li W, Zhang Q, Li N, Sun T (2012) Genistein inhibit cytokines or growth factor-induced proliferation and transformation phenotype in fibroblast-like synoviocytes of rheumatoid arthritis. Inflammation 35:377\u2013387","journal-title":"Inflammation"},{"key":"1731_CR114","first-page":"5942","volume":"14","author":"L Zhao","year":"2017","unstructured":"Zhao L, Cen F, Tian F, Li M-J, Zhang Q, Shen HY, Shen X-C, Zhou MM, Du J (2017) Combination treatment with quercetin and resveratrol attenuates high fat diet-induced obesity and associated inflammation in rats via the Ampk\u03b11\/Sirt1 signaling pathway. Exp Ther Med 14:5942\u20135948","journal-title":"Exp Ther Med"},{"key":"1731_CR115","first-page":"4931","volume":"9","author":"Z Zheng","year":"2015","unstructured":"Zheng Z, Sun Y, Liu Z, Zhang M, Li C, Cai H (2015) The effect of curcumin and its nanoformulation on adjuvant-induced arthritis in rats. Drug des Dev Ther 9:4931","journal-title":"Drug des Dev Ther"},{"key":"1731_CR116","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1016\/j.intimp.2017.02.009","volume":"45","author":"W Zheng","year":"2017","unstructured":"Zheng W, Feng Z, You S, Zhang H, Tao Z, Wang Q, Chen H, Wu Y (2017) Fisetin inhibits Il-1\u03b2-induced inflammatory response in human osteoarthritis chondrocytes through activating Sirt1 and attenuates the progression of osteoarthritis in mice. Int Immunopharmacol 45:135\u2013147","journal-title":"Int Immunopharmacol"}],"container-title":["Inflammopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10787-025-01731-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10787-025-01731-z\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10787-025-01731-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,18]],"date-time":"2025-06-18T07:03:00Z","timestamp":1750230180000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10787-025-01731-z"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4,12]]},"references-count":119,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2025,5]]}},"alternative-id":["1731"],"URL":"https:\/\/doi.org\/10.1007\/s10787-025-01731-z","relation":{},"ISSN":["0925-4692","1568-5608"],"issn-type":[{"value":"0925-4692","type":"print"},{"value":"1568-5608","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,4,12]]},"assertion":[{"value":"14 September 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 December 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 April 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Authors have no financial or other conflicts to disclose.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}