{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T14:45:59Z","timestamp":1787496359939,"version":"build-2736575974"},"reference-count":185,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2025,4,22]],"date-time":"2025-04-22T00:00:00Z","timestamp":1745280000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,4,22]],"date-time":"2025-04-22T00:00:00Z","timestamp":1745280000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Inflammopharmacol"],"published-print":{"date-parts":[[2025,5]]},"DOI":"10.1007\/s10787-025-01751-9","type":"journal-article","created":{"date-parts":[[2025,4,22]],"date-time":"2025-04-22T15:33:44Z","timestamp":1745336024000},"page":"2477-2492","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Multifaceted roles of melatonin in oncology: an insight into its therapeutic potential in cancer management"],"prefix":"10.1007","volume":"33","author":[{"given":"Hossein","family":"Maghsoudi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Farhad","family":"Sheikhnia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nooshin","family":"Hajmalek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fatemeh Dadash","family":"Gholipour","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shahriar","family":"Alipour","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mansour","family":"Ghorbanpour","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Farzanegan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seyed Mostafa","family":"Mir","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0328-4753","authenticated-orcid":false,"given":"Mohammad Yousef","family":"Memar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,4,22]]},"reference":[{"issue":"16","key":"1751_CR1","doi-asserted-by":"publisher","first-page":"2997","DOI":"10.1007\/s00018-014-1579-2","volume":"71","author":"D Acu\u00f1a-Castroviejo","year":"2014","unstructured":"Acu\u00f1a-Castroviejo D, Escames G, Venegas C, D\u00edaz-Casado ME, Lima-Cabello E, L\u00f3pez LC et al (2014) Extrapineal melatonin: sources, regulation, and potential functions. Cell Mol Life Sci 71(16):2997\u20133025","journal-title":"Cell Mol Life Sci"},{"issue":"1","key":"1751_CR2","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1007\/s12282-018-0894-0","volume":"26","author":"A Aftab","year":"2019","unstructured":"Aftab A, Shahzad S, Hussain HMJ, Khan R, Irum S, Tabassum S (2019) CDKN2A\/P16INK4A variants association with breast cancer and their in-silico analysis. Breast Cancer 26(1):11\u201328","journal-title":"Breast Cancer"},{"key":"1751_CR3","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2024.116487","volume":"174","author":"S Ahmadi","year":"2024","unstructured":"Ahmadi S, Taghizadieh M, Mehdizadehfar E, Hasani A, Fard JK, Feizi H et al (2024) Gut microbiota in neurological diseases: melatonin plays an important regulatory role. Biomed Pharm 174:116487","journal-title":"Biomed Pharm"},{"issue":"2","key":"1751_CR4","doi-asserted-by":"publisher","first-page":"145","DOI":"10.3390\/biom14020145","volume":"14","author":"N Al-Ansari","year":"2024","unstructured":"Al-Ansari N, Samuel SM, B\u00fcsselberg D (2024) Unveiling the protective role of melatonin in osteosarcoma: current knowledge and limitations. Biomolecules 14(2):145","journal-title":"Biomolecules"},{"issue":"2","key":"1751_CR5","first-page":"560","volume":"52","author":"C Alonso-Gonz\u00e1lez","year":"2018","unstructured":"Alonso-Gonz\u00e1lez C, Men\u00e9ndez-Men\u00e9ndez J, Gonz\u00e1lez-Gonz\u00e1lez A, Gonz\u00e1lez A, Cos S, Mart\u00ednez-Campa C (2018) Melatonin enhances the apoptotic effects and modulates the changes in gene expression induced by docetaxel in MCF-7 human breast cancer cells. Int J Oncol 52(2):560\u201370","journal-title":"Int J Oncol"},{"issue":"2","key":"1751_CR6","doi-asserted-by":"publisher","first-page":"548","DOI":"10.3390\/ijms21020548","volume":"21","author":"A Alvarez-Artime","year":"2020","unstructured":"Alvarez-Artime A, Cernuda-Cernuda R, Cepas V, Gonzalez-Menendez P, Fernadez-Vega S, Quiros-Gonzalez I et al (2020) Melatonin-induced cytoskeleton reorganization leads to inhibition of melanoma cancer cell proliferation. Int J Mol Sci 21(2):548","journal-title":"Int J Mol Sci"},{"issue":"1","key":"1751_CR7","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1038\/s41698-017-0026-x","volume":"1","author":"JL Arbiser","year":"2017","unstructured":"Arbiser JL, Bonner MY, Gilbert LC (2017) Targeting the duality of cancer. NPJ Precis Oncol 1(1):23","journal-title":"NPJ Precis Oncol"},{"issue":"1","key":"1751_CR8","first-page":"1015","volume":"2","author":"R Ataee","year":"2017","unstructured":"Ataee R, Shokrzadeh M, Jafari-Sabet M, Nasrabadi Nasri N, Ataie A, Haghi Aminjan H (2017) The role of melatonin and melatonin receptors in pharmacology and pharmacotherapy of cancer. Austin Oncol 2(1):1015","journal-title":"Austin Oncol"},{"key":"1751_CR9","doi-asserted-by":"publisher","first-page":"319","DOI":"10.3389\/fgene.2012.00319","volume":"3","author":"J Azpurua","year":"2013","unstructured":"Azpurua J, Seluanov A (2013) Long-lived cancer-resistant rodents as new model species for cancer research. Front Genet 3:319","journal-title":"Front Genet"},{"issue":"6","key":"1751_CR10","doi-asserted-by":"publisher","first-page":"1244","DOI":"10.1093\/biolre\/iox053","volume":"96","author":"RS Barberino","year":"2017","unstructured":"Barberino RS, Menezes VG, Ribeiro AE, Palheta RC Jr, Jiang X, Smitz JE et al (2017) Melatonin protects against cisplatin-induced ovarian damage in mice via the MT1 receptor and antioxidant activity. Biol Reprod 96(6):1244\u201355","journal-title":"Biol Reprod"},{"issue":"10","key":"1751_CR11","doi-asserted-by":"publisher","first-page":"792","DOI":"10.1038\/nrm1493","volume":"5","author":"J Bartek","year":"2004","unstructured":"Bartek J, Lukas C, Lukas J (2004) Checking on DNA damage in S phase. Nat Rev Mol Cell Biol 5(10):792\u2013804","journal-title":"Nat Rev Mol Cell Biol"},{"issue":"2","key":"1751_CR12","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1111\/j.1600-079X.1985.tb00633.x","volume":"2","author":"C Bartsch","year":"1985","unstructured":"Bartsch C, Bartsch H, Fl\u00fcchter SH, Attanasio A, Gupta D (1985) Evidence for modulation of melatonin secretion in men with benign and malignant tumors of the prostate: relationship with the pituitary hormones. J Pineal Res 2(2):121\u201332","journal-title":"J Pineal Res"},{"key":"1751_CR13","doi-asserted-by":"crossref","unstructured":"Bellet M, Orozco-Solis R, Sahar S, Eckel-Mahan K, Sassone-Corsi P (2011) The time of metabolism: NAD+, SIRT1, and the circadian clock. Cold Spring Harbor symposia on quantitative biology. Cold Spring Harbor Laboratory Press","DOI":"10.1101\/sqb.2011.76.010520"},{"issue":"1","key":"1751_CR14","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1007\/s11010-019-03617-5","volume":"462","author":"S Bhattacharya","year":"2019","unstructured":"Bhattacharya S, Patel KK, Dehari D, Agrawal AK, Singh S (2019) Melatonin and its ubiquitous anticancer effects. Mol Cell Biochem 462(1):133\u201355","journal-title":"Mol Cell Biochem"},{"issue":"2","key":"1751_CR15","doi-asserted-by":"publisher","first-page":"113","DOI":"10.2174\/1568026023394407","volume":"2","author":"DE Blask","year":"2002","unstructured":"Blask DE, Sauer LA, Dauchy RT (2002) Melatonin as a chronobiotic\/anticancer agent: cellular, biochemical, and molecular mechanisms of action and their implications for circadian-based cancer therapy. Curr Top Med Chem 2(2):113\u201332","journal-title":"Curr Top Med Chem"},{"issue":"12","key":"1751_CR16","doi-asserted-by":"publisher","first-page":"23448","DOI":"10.3390\/ijms151223448","volume":"15","author":"MA Bonmati-Carrion","year":"2014","unstructured":"Bonmati-Carrion MA, Arguelles-Prieto R, Martinez-Madrid MJ, Reiter R, Hardeland R, Rol MA et al (2014) Protecting the melatonin rhythm through circadian healthy light exposure. Int J Mol Sci 15(12):23448\u2013500","journal-title":"Int J Mol Sci"},{"issue":"1","key":"1751_CR17","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1111\/jpi.12270","volume":"60","author":"TF Borin","year":"2016","unstructured":"Borin TF, Arbab AS, Gelaleti GB, Ferreira LC, Moschetta MG, Jardim-Perassi BV et al (2016) Melatonin decreases breast cancer metastasis by modulating Rho-associated kinase protein-1 expression. J Pineal Res 60(1):3\u201315","journal-title":"J Pineal Res"},{"issue":"5","key":"1751_CR18","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1016\/j.tibs.2004.03.006","volume":"29","author":"DP Brazil","year":"2004","unstructured":"Brazil DP, Yang Z-Z, Hemmings BA (2004) Advances in protein kinase B signalling: AKTion on multiple fronts. Trends Biochem Sci 29(5):233\u201342","journal-title":"Trends Biochem Sci"},{"issue":"34","key":"1751_CR19","doi-asserted-by":"publisher","first-page":"56698","DOI":"10.18632\/oncotarget.18082","volume":"8","author":"DE Butler","year":"2017","unstructured":"Butler DE, Marlein C, Walker HF, Frame FM, Mann VM, Simms MS et al (2017) Inhibition of the PI3K\/AKT\/mTOR pathway activates autophagy and compensatory Ras\/Raf\/MEK\/ERK signalling in prostate cancer. Oncotarget 8(34):56698","journal-title":"Oncotarget"},{"issue":"5","key":"1751_CR20","doi-asserted-by":"publisher","first-page":"299","DOI":"10.1038\/nrc3496","volume":"13","author":"MJ Bywater","year":"2013","unstructured":"Bywater MJ, Pearson RB, McArthur GA, Hannan RD (2013) Dysregulation of the basal RNA polymerase transcription apparatus in cancer. Nat Rev Cancer 13(5):299\u2013314","journal-title":"Nat Rev Cancer"},{"issue":"1","key":"1751_CR21","first-page":"45","volume":"49","author":"J Cabrera","year":"2010","unstructured":"Cabrera J, Negr\u00edn G, Est\u00e9vez F, Loro J, Reiter RJ, Quintana J (2010) Melatonin decreases cell proliferation and induces melanogenesis in human melanoma SK-MEL-1 cells. J Pineal Res 49(1):45\u201354","journal-title":"J Pineal Res"},{"issue":"2","key":"1751_CR22","doi-asserted-by":"publisher","first-page":"442","DOI":"10.1038\/bjc.2012.563","volume":"108","author":"S Carbajo-Pescador","year":"2013","unstructured":"Carbajo-Pescador S, Steinmetz C, Kashyap A, Lorenz S, Mauriz JL, Heise M et al (2013) Melatonin induces transcriptional regulation of Bim by FoxO3a in HepG2 cells. Br J Cancer 108(2):442\u20139","journal-title":"Br J Cancer"},{"issue":"1","key":"1751_CR23","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1111\/j.1600-079X.2009.00727.x","volume":"48","author":"S Casado-Zapico","year":"2010","unstructured":"Casado-Zapico S, Rodriguez-Blanco J, Garc\u00eda-Santos G, Mart\u00edn V, S\u00e1nchez-S\u00e1nchez AM, Antol\u00edn I et al (2010) Synergistic antitumor effect of melatonin with several chemotherapeutic drugs on human Ewing sarcoma cancer cells: potentiation of the extrinsic apoptotic pathway. J Pineal Res 48(1):72\u201380","journal-title":"J Pineal Res"},{"issue":"7","key":"1751_CR24","doi-asserted-by":"publisher","first-page":"1263","DOI":"10.1038\/sj.leu.2402945","volume":"17","author":"F Chang","year":"2003","unstructured":"Chang F, Steelman LS, Lee JT, Shelton JG, Navolanic PM, Blalock WL et al (2003) Signal transduction mediated by the Ras\/Raf\/MEK\/ERK pathway from cytokine receptors to transcription factors: potential targeting for therapeutic intervention. Leukemia 17(7):1263\u201393","journal-title":"Leukemia"},{"issue":"11","key":"1751_CR25","doi-asserted-by":"publisher","first-page":"5649","DOI":"10.3390\/ijms22115649","volume":"22","author":"YC Chao","year":"2021","unstructured":"Chao YC, Lee KY, Wu SM, Kuo DY, Shueng PW, Lin CW (2021) Melatonin downregulates PD-L1 expression and modulates tumor immunity in KRAS-mutant non-small cell lung cancer. Int J Mol Sci 22(11):5649","journal-title":"Int J Mol Sci"},{"issue":"2","key":"1751_CR26","doi-asserted-by":"publisher","first-page":"208","DOI":"10.1111\/jpi.12341","volume":"61","author":"X Chen","year":"2016","unstructured":"Chen X, Hao A, Li X, Du Z, Li H, Wang H et al (2016) Melatonin inhibits tumorigenicity of glioblastoma stem-like cells via the AKT-EZH2-STAT3 signaling axis. J Pineal Res 61(2):208\u201317","journal-title":"J Pineal Res"},{"issue":"1","key":"1751_CR27","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s11626-017-0200-z","volume":"54","author":"L Chen","year":"2018","unstructured":"Chen L, Liu L, Li Y, Gao J (2018) Melatonin increases human cervical cancer HeLa cells apoptosis induced by cisplatin via inhibition of JNK\/Parkin\/mitophagy axis. In Vitro Cell Dev Biol-Animal 54(1):1\u201310","journal-title":"In Vitro Cell Dev Biol-Animal"},{"issue":"1","key":"1751_CR28","first-page":"451","volume":"10","author":"BS Chhikara","year":"2023","unstructured":"Chhikara BS, Parang K (2023) Global Cancer Statistics 2022: the trends projection analysis. Chem Biol Lett 10(1):451","journal-title":"Chem Biol Lett"},{"issue":"9","key":"1751_CR29","doi-asserted-by":"publisher","first-page":"1211","DOI":"10.3390\/biom10091211","volume":"10","author":"DM Chitimus","year":"2020","unstructured":"Chitimus DM, Popescu MR, Voiculescu SE, Panaitescu AM, Pavel B, Zagrean L et al (2020) Melatonin\u2019s impact on antioxidative and anti-inflammatory reprogramming in homeostasis and disease. Biomolecules 10(9):1211","journal-title":"Biomolecules"},{"issue":"2","key":"1751_CR30","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1016\/S0092-8674(04)00046-7","volume":"116","author":"NN Danial","year":"2004","unstructured":"Danial NN, Korsmeyer SJ (2004) Cell death: critical control points. Cell. 116(2):205\u201319","journal-title":"Cell."},{"issue":"15","key":"1751_CR31","doi-asserted-by":"publisher","first-page":"4099","DOI":"10.1158\/0008-5472.CAN-13-3156","volume":"74","author":"RT Dauchy","year":"2014","unstructured":"Dauchy RT, Xiang S, Mao L, Brimer S, Wren MA, Yuan L et al (2014) Circadian and melatonin disruption by exposure to light at night drives intrinsic resistance to tamoxifen therapy in breast cancer. Cancer Res 74(15):4099\u2013110","journal-title":"Cancer Res"},{"key":"1751_CR32","doi-asserted-by":"publisher","first-page":"1006","DOI":"10.3389\/fonc.2020.01006","volume":"10","author":"A Dun","year":"2020","unstructured":"Dun A, Zhao X, Jin X, Wei T, Gao X, Wang Y et al (2020) Association between night-shift work and cancer risk: updated systematic review and meta-analysis. Front Oncol 10:1006","journal-title":"Front Oncol"},{"issue":"6990","key":"1751_CR33","doi-asserted-by":"publisher","first-page":"457","DOI":"10.1038\/nature02625","volume":"429","author":"G Egger","year":"2004","unstructured":"Egger G, Liang G, Aparicio A, Jones PA (2004) Epigenetics in human disease and prospects for epigenetic therapy. Nature 429(6990):457\u201363","journal-title":"Nature"},{"issue":"12","key":"1751_CR34","doi-asserted-by":"publisher","first-page":"1473","DOI":"10.3748\/wjg.v16.i12.1473","volume":"16","author":"L-L Fan","year":"2010","unstructured":"Fan L-L, Sun G-P, Wei W, Wang Z-G, Ge L, Fu W-Z et al (2010) Melatonin and doxorubicin synergistically induce cell apoptosis in human hepatoma cell lines. W J Gastroenterol WJG 16(12):1473","journal-title":"W J Gastroenterol WJG"},{"issue":"2","key":"1751_CR35","doi-asserted-by":"publisher","first-page":"184","DOI":"10.1111\/jpi.12061","volume":"55","author":"L Fan","year":"2013","unstructured":"Fan L, Sun G, Ma T, Zhong F, Lei Y, Li X et al (2013) Melatonin reverses tunicamycin-induced endoplasmic reticulum stress in human hepatocellular carcinoma cells and improves cytotoxic response to doxorubicin by increasing CHOP and decreasing survivin. J Pineal Res 55(2):184\u201394","journal-title":"J Pineal Res"},{"issue":"5","key":"1751_CR36","doi-asserted-by":"publisher","first-page":"5613","DOI":"10.1002\/jcp.27391","volume":"234","author":"B Farhood","year":"2019","unstructured":"Farhood B, Goradel NH, Mortezaee K, Khanlarkhani N, Najafi M, Sahebkar A (2019) Melatonin and cancer: from the promotion of genomic stability to use in cancer treatment. J Cell Physiol 234(5):5613\u201327","journal-title":"J Cell Physiol"},{"issue":"7","key":"1751_CR37","doi-asserted-by":"publisher","first-page":"791","DOI":"10.4161\/epi.6.7.16209","volume":"6","author":"C Faulk","year":"2011","unstructured":"Faulk C, Dolinoy DC (2011) Timing is everything: the when and how of environmentally induced changes in the epigenome of animals. Epigenetics 6(7):791\u20137","journal-title":"Epigenetics"},{"key":"1751_CR38","doi-asserted-by":"publisher","first-page":"1086","DOI":"10.3389\/fphar.2018.01086","volume":"9","author":"G Favero","year":"2018","unstructured":"Favero G, Moretti E, Bonomini F, Reiter RJ, Rodella LF, Rezzani R (2018) Promising antineoplastic actions of melatonin. Front Pharmacol 9:1086","journal-title":"Front Pharmacol"},{"issue":"5","key":"1751_CR39","doi-asserted-by":"publisher","first-page":"1129","DOI":"10.3390\/molecules23051129","volume":"23","author":"DG Franco","year":"2018","unstructured":"Franco DG, Moretti IF, Marie SKN (2018) Mitochondria transcription factor a: a putative target for the effect of melatonin on U87MG malignant glioma cell line. Molecules 23(5):1129","journal-title":"Molecules"},{"issue":"5","key":"1751_CR40","doi-asserted-by":"publisher","first-page":"1129","DOI":"10.3390\/molecules23051129","volume":"23","author":"DG Franco","year":"2018","unstructured":"Franco DG, Moretti IF, Marie SK (2018) Mitochondria transcription factor a: a putative target for the effect of melatonin on U87MG malignant glioma cell line. Molecules 23(5):1129","journal-title":"Molecules"},{"issue":"1","key":"1751_CR41","doi-asserted-by":"publisher","first-page":"388","DOI":"10.1074\/jbc.M611043200","volume":"283","author":"K Fujiwara","year":"2008","unstructured":"Fujiwara K, Daido S, Yamamoto A, Kobayashi R, Yokoyama T, Aoki H et al (2008) Pivotal role of the cyclin-dependent kinase inhibitor p21WAF1\/CIP1 in apoptosis and autophagy. J Biol Chem 283(1):388\u201397","journal-title":"J Biol Chem"},{"issue":"11","key":"1751_CR42","doi-asserted-by":"publisher","first-page":"bvaa115","DOI":"10.1210\/jendso\/bvaa115","volume":"4","author":"GA Greendale","year":"2020","unstructured":"Greendale GA, Witt-Enderby P, Karlamangla AS, Munmun F, Crawford S, Huang M et al (2020) Melatonin patterns and levels during the human menstrual cycle and after menopause. J Endocr Soc 4(11):bvaa115","journal-title":"J Endocr Soc"},{"issue":"1","key":"1751_CR43","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1016\/j.biocel.2008.08.035","volume":"41","author":"B Grimaldi","year":"2009","unstructured":"Grimaldi B, Nakahata Y, Kaluzova M, Masubuchi S, Sassone-Corsi P (2009) Chromatin remodeling, metabolism and circadian clocks: the interplay of CLOCK and SIRT1. Int J Biochem Cell Biol 41(1):81\u20136","journal-title":"Int J Biochem Cell Biol"},{"issue":"9","key":"1751_CR44","doi-asserted-by":"publisher","first-page":"937","DOI":"10.1080\/17425255.2018.1513492","volume":"14","author":"H Haghi-Aminjan","year":"2018","unstructured":"Haghi-Aminjan H, Farhood B, Rahimifard M, Didari T, Baeeri M, Hassani S et al (2018) The protective role of melatonin in chemotherapy-induced nephrotoxicity: a systematic review of non-clinical studies. Exp Opinion Drug Metabol Toxicol 14(9):937\u201350","journal-title":"Exp Opinion Drug Metabol Toxicol"},{"issue":"3","key":"1751_CR45","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1111\/jphp.12855","volume":"70","author":"H Haghi-Aminjan","year":"2018","unstructured":"Haghi-Aminjan H, Asghari MH, Farhood B, Rahimifard M, Hashemi Goradel N, Abdollahi M (2018) The role of melatonin on chemotherapy-induced reproductive toxicity. J Pharm Pharmacol 70(3):291\u2013306","journal-title":"J Pharm Pharmacol"},{"issue":"5","key":"1751_CR46","doi-asserted-by":"publisher","first-page":"646","DOI":"10.1016\/j.cell.2011.02.013","volume":"144","author":"D Hanahan","year":"2011","unstructured":"Hanahan D, Weinberg RA (2011) Hallmarks of cancer: the next generation. Cell 144(5):646\u201374","journal-title":"Cell"},{"issue":"1","key":"1751_CR47","first-page":"13","volume":"7","author":"J Hao","year":"2017","unstructured":"Hao J, Li Z, Zhang C, Yu W, Tang Z, Li Y et al (2017) Targeting NF-\u03baB\/AP-2\u03b2 signaling to enhance antitumor activity of cisplatin by melatonin in hepatocellular carcinoma cells. Am J Cancer Res 7(1):13","journal-title":"Am J Cancer Res"},{"issue":"10","key":"1751_CR48","doi-asserted-by":"publisher","first-page":"18221","DOI":"10.3390\/ijms151018221","volume":"15","author":"R Hardeland","year":"2014","unstructured":"Hardeland R (2014) Melatonin, noncoding RNAs, messenger RNA stability and epigenetics\u2014evidence, hints, gaps and perspectives. Int J Mol Sci 15(10):18221\u201352","journal-title":"Int J Mol Sci"},{"issue":"5","key":"1751_CR49","doi-asserted-by":"publisher","first-page":"1223","DOI":"10.3390\/ijms20051223","volume":"20","author":"R Hardeland","year":"2019","unstructured":"Hardeland R (2019) Aging, melatonin, and the pro-and anti-inflammatory networks. Int J Mol Sci 20(5):1223","journal-title":"Int J Mol Sci"},{"issue":"2","key":"1751_CR50","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1111\/j.1600-079X.2011.00934.x","volume":"52","author":"R Hardeland","year":"2012","unstructured":"Hardeland R, Madrid JA, Tan DX, Reiter RJ (2012) Melatonin, the circadian multioscillator system and health: the need for detailed analyses of peripheral melatonin signaling. J Pineal Res 52(2):139\u201366","journal-title":"J Pineal Res"},{"issue":"4930","key":"1751_CR51","doi-asserted-by":"publisher","first-page":"629","DOI":"10.1126\/science.2683079","volume":"246","author":"LH Hartwell","year":"1989","unstructured":"Hartwell LH, Weinert TA (1989) Checkpoints: controls that ensure the order of cell cycle events. Science 246(4930):629\u201334","journal-title":"Science"},{"issue":"1","key":"1751_CR52","volume":"2014","author":"M Hassan","year":"2014","unstructured":"Hassan M, Watari H, AbuAlmaaty A, Ohba Y, Sakuragi N (2014) [Retracted] apoptosis and molecular targeting therapy in cancer. BioMed Res Int 2014(1):150845","journal-title":"BioMed Res Int"},{"key":"1751_CR53","doi-asserted-by":"publisher","first-page":"124508","DOI":"10.1016\/j.ijbiomac.2023.124508","volume":"241","author":"S Hassani","year":"2023","unstructured":"Hassani S, Maghsoudi H, Fattahi F, Malekinejad F, Hajmalek N, Sheikhnia F et al (2023) Flavonoids nanostructures promising therapeutic efficiencies in colorectal cancer. Int J Biol Macromol 241:124508","journal-title":"Int J Biol Macromol"},{"issue":"1","key":"1751_CR54","doi-asserted-by":"publisher","first-page":"59","DOI":"10.32794\/mr112500141","volume":"6","author":"N Heydari","year":"2023","unstructured":"Heydari N, Memar MY, Reiter RJ, Rezatabar S, Arab-Bafran Z, Jaz AA et al (2023) Melatonin: an anticancer molecule in esophageal squamous cell carcinoma: a mechanistic review. Melat Res 6(1):59\u201371","journal-title":"Melat Res"},{"issue":"4","key":"1751_CR55","doi-asserted-by":"publisher","first-page":"337","DOI":"10.1177\/1534735409353332","volume":"8","author":"SM Hill","year":"2009","unstructured":"Hill SM, Frasch T, Xiang S, Yuan L, Duplessis T, Mao L (2009) Molecular mechanisms of melatonin anticancer effects. Integr Cancer Therap 8(4):337\u201346","journal-title":"Integr Cancer Therap"},{"issue":"3","key":"1751_CR56","doi-asserted-by":"publisher","first-page":"R183","DOI":"10.1530\/ERC-15-0030","volume":"22","author":"SM Hill","year":"2015","unstructured":"Hill SM, Belancio VP, Dauchy RT, Xiang S, Brimer S, Mao L et al (2015) Melatonin: an inhibitor of breast cancer. Endocrine-Related Cancer 22(3):R183\u2013R204","journal-title":"Endocrine-Related Cancer"},{"issue":"2","key":"1751_CR57","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1038\/nrg3863","volume":"16","author":"D Holoch","year":"2015","unstructured":"Holoch D, Moazed D (2015) RNA-mediated epigenetic regulation of gene expression. Nat Rev Genet 16(2):71\u201384","journal-title":"Nat Rev Genet"},{"issue":"3","key":"1751_CR58","doi-asserted-by":"publisher","first-page":"264","DOI":"10.1111\/jpi.12119","volume":"56","author":"Y Hong","year":"2014","unstructured":"Hong Y, Won J, Lee Y, Lee S, Park K, Chang KT et al (2014) Melatonin treatment induces interplay of apoptosis, autophagy, and senescence in human colorectal cancer cells. J Pineal Res 56(3):264\u201374","journal-title":"J Pineal Res"},{"key":"1751_CR59","doi-asserted-by":"publisher","first-page":"877","DOI":"10.1016\/j.omtn.2019.12.022","volume":"19","author":"MJ Hsieh","year":"2020","unstructured":"Hsieh MJ, Lin CW, Su SC, Reiter RJ, Chen AW, Chen MK et al (2020) Effects of miR-34b\/miR-892a upregulation and inhibition of ABCB1\/ABCB4 on melatonin-induced apoptosis in VCR-resistant oral cancer cells. Mol Ther Nucleic Acids 19:877\u201389","journal-title":"Mol Ther Nucleic Acids"},{"issue":"1","key":"1751_CR60","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/ncb3452","volume":"19","author":"N Hustedt","year":"2017","unstructured":"Hustedt N, Durocher D (2017) The control of DNA repair by the cell cycle. Nat Cell Biol 19(1):1\u20139","journal-title":"Nat Cell Biol"},{"issue":"6","key":"1751_CR61","doi-asserted-by":"publisher","first-page":"347","DOI":"10.1038\/nrn.2017.46","volume":"18","author":"J-Y Hwang","year":"2017","unstructured":"Hwang J-Y, Aromolaran KA, Zukin RS (2017) The emerging field of epigenetics in neurodegeneration and neuroprotection. Nat Rev Neurosci 18(6):347\u201361","journal-title":"Nat Rev Neurosci"},{"issue":"2","key":"1751_CR62","doi-asserted-by":"publisher","first-page":"205","DOI":"10.15171\/apb.2019.024","volume":"9","author":"R Jan","year":"2019","unstructured":"Jan R (2019) Understanding apoptosis and apoptotic pathways targeted cancer therapeutics. Adv Pharm Bull 9(2):205","journal-title":"Adv Pharm Bull"},{"issue":"3","key":"1751_CR63","doi-asserted-by":"publisher","first-page":"336","DOI":"10.1111\/jpi.12316","volume":"60","author":"H Jang","year":"2016","unstructured":"Jang H, Lee O-H, Lee Y, Yoon H, Chang EM, Park M et al (2016) Melatonin prevents cisplatin-induced primordial follicle loss via suppression of PTEN\/AKT\/FOXO3a pathway activation in the mouse ovary. J Pineal Res 60(3):336\u201347","journal-title":"J Pineal Res"},{"issue":"3","key":"1751_CR64","doi-asserted-by":"publisher","DOI":"10.1111\/jpi.12432","volume":"63","author":"H Jang","year":"2017","unstructured":"Jang H, Na Y, Hong K, Lee S, Moon S, Cho M et al (2017) Synergistic effect of melatonin and ghrelin in preventing cisplatin-induced ovarian damage via regulation of FOXO3a phosphorylation and binding to the p27Kip1 promoter in primordial follicles. J Pineal Res 63(3):e12432","journal-title":"J Pineal Res"},{"issue":"4","key":"1751_CR65","doi-asserted-by":"publisher","first-page":"503","DOI":"10.32794\/mr112500165","volume":"6","author":"AA Jazi","year":"2023","unstructured":"Jazi AA, Mohammadzadeh F, Amirkhanlou S, Bafarani ZA, Mir SM (2023) Nanocarriers for melatonin delivery. Melatonin Res 6(4):503\u201319","journal-title":"Melatonin Res"},{"issue":"1","key":"1751_CR66","first-page":"879746","volume":"2013","author":"JH Jung","year":"2013","unstructured":"Jung JH, Sohn EJ, Shin EA, Lee D, Kim B, Jung D-B et al (2013) Melatonin suppresses the expression of 45S preribosomal RNA and upstream binding factor and enhances the antitumor activity of puromycin in MDA-MB-231 breast cancer cells. Evidence-Based Compl Altern Med 2013(1):879746","journal-title":"Evidence-Based Compl Altern Med"},{"key":"1751_CR67","volume":"2013","author":"JH Jung","year":"2013","unstructured":"Jung JH, Sohn EJ, Shin EA, Lee D, Kim B, Jung DB et al (2013) Melatonin suppresses the expression of 45S preribosomal RNA and upstream binding factor and enhances the antitumor activity of puromycin in MDA-MB-231 breast cancer cells. Evid Based Compl Altern Med eCAM 2013:879746","journal-title":"Evid Based Compl Altern Med eCAM"},{"issue":"9","key":"1751_CR68","doi-asserted-by":"publisher","first-page":"7629","DOI":"10.1074\/jbc.M110.208173","volume":"286","author":"Y Kawai","year":"2011","unstructured":"Kawai Y, Gardu\u00f1o L, Theodore M, Yang J, Arinze IJ (2011) Acetylation-deacetylation of the transcription factor Nrf2 (nuclear factor erythroid 2-related factor 2) regulates its transcriptional activity and nucleocytoplasmic localization. J Biol Chem 286(9):7629\u201340","journal-title":"J Biol Chem"},{"key":"1751_CR69","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s12929-015-0156-9","volume":"22","author":"S Khan","year":"2015","unstructured":"Khan S, Adhikari JS, Rizvi MA, Chaudhury NK (2015) Radioprotective potential of melatonin against 60 Co \u03b3-ray-induced testicular injury in male C57BL\/6 mice. J Biomed Sci 22:1\u201315","journal-title":"J Biomed Sci"},{"issue":"2","key":"1751_CR70","doi-asserted-by":"publisher","first-page":"501","DOI":"10.1002\/tox.22254","volume":"32","author":"S Khan","year":"2017","unstructured":"Khan S, Adhikari JS, Rizvi MA, Chaudhury NK (2017) Melatonin attenuates 60Co \u03b3-ray-induced hematopoietic, immunological and gastrointestinal injuries in C57BL\/6 male mice. Environ Toxicol 32(2):501\u201318","journal-title":"Environ Toxicol"},{"issue":"3","key":"1751_CR71","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1111\/j.1600-079X.1988.tb00651.x","volume":"5","author":"R Khoory","year":"1988","unstructured":"Khoory R, Stemme D (1988) Plasma melatonin levels in patients suffering from colorectal carcinoma. J Pineal Res 5(3):251\u20138","journal-title":"J Pineal Res"},{"issue":"6","key":"1751_CR72","doi-asserted-by":"publisher","first-page":"711","DOI":"10.1515\/hsz-2018-0397","volume":"400","author":"M Khosravi","year":"2019","unstructured":"Khosravi M, Poursaleh A, Ghasempour G, Farhad S, Najafi M (2019) The effects of oxidative stress on the development of atherosclerosis. Biol Chem 400(6):711\u201332","journal-title":"Biol Chem"},{"issue":"2","key":"1751_CR73","doi-asserted-by":"publisher","first-page":"244","DOI":"10.1111\/j.1600-079X.2011.00935.x","volume":"52","author":"JH Kim","year":"2012","unstructured":"Kim JH, Jeong SJ, Kim B, Yun SM, Choi DY, Kim SH (2012) Melatonin synergistically enhances cisplatin-induced apoptosis via the dephosphorylation of ERK\/p90 ribosomal S6 kinase\/heat shock protein 27 in SK-OV-3 cells. J Pineal Res 52(2):244\u201352","journal-title":"J Pineal Res"},{"issue":"3","key":"1751_CR74","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0092627","volume":"9","author":"HS Kim","year":"2014","unstructured":"Kim HS, Kim T-J, Yoo Y-M (2014) Melatonin combined with endoplasmic reticulum stress induces cell death via the PI3K\/Akt\/mTOR pathway in B16F10 melanoma cells. PLoS One 9(3):e92627","journal-title":"PLoS One"},{"issue":"4","key":"1751_CR75","doi-asserted-by":"publisher","first-page":"379","DOI":"10.1111\/j.1600-079X.2007.00539.x","volume":"44","author":"SR Kimball","year":"2008","unstructured":"Kimball SR, Abbas A, Jefferson LS (2008) Melatonin represses oxidative stress-induced activation of the MAP kinase and mTOR signaling pathways in H4IIE hepatoma cells through inhibition of Ras. J Pineal Res 44(4):379\u201386","journal-title":"J Pineal Res"},{"key":"1751_CR76","doi-asserted-by":"publisher","first-page":"113","DOI":"10.3389\/fphar.2012.00113","volume":"3","author":"GL Klement","year":"2012","unstructured":"Klement GL, Goukassian D, Hlatky L, Carrozza J, Morgan JP, Yan X (2012) Cancer therapy targeting the HER2-PI3K pathway: potential impact on the heart. Front Pharmacol 3:113","journal-title":"Front Pharmacol"},{"key":"1751_CR77","doi-asserted-by":"publisher","first-page":"474","DOI":"10.1111\/j.1749-6632.1994.tb56852.x","volume":"719","author":"P Kloeden","year":"1994","unstructured":"Kloeden P, R\u00f6ssler R, R\u00f6ssler O (1994) Artificial life extension. The epigenetic approach. Ann NY Acad Sci 719:474\u201382","journal-title":"Ann NY Acad Sci"},{"issue":"11","key":"1751_CR78","doi-asserted-by":"publisher","first-page":"859","DOI":"10.1016\/j.tem.2020.08.001","volume":"31","author":"X Kong","year":"2020","unstructured":"Kong X, Gao R, Wang Z, Wang X, Fang Y, Gao J et al (2020) Melatonin: a potential therapeutic option for breast cancer. Trends Endocrinol Metab 31(11):859\u201371","journal-title":"Trends Endocrinol Metab"},{"issue":"2","key":"1751_CR79","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1111\/j.1600-079X.2008.00648.x","volume":"46","author":"P Kongsuphol","year":"2009","unstructured":"Kongsuphol P, Mukda S, Nopparat C, Villarroel A, Govitrapong P (2009) Melatonin attenuates methamphetamine-induced deactivation of the mammalian target of rapamycin signaling to induce autophagy in SK-N-SH cells. J Pineal Res 46(2):199\u2013206","journal-title":"J Pineal Res"},{"issue":"1","key":"1751_CR80","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1111\/j.1600-079X.2007.00509.x","volume":"44","author":"A Korkmaz","year":"2008","unstructured":"Korkmaz A, Reiter RJ (2008) Epigenetic regulation: a new research area for melatonin? J Pineal Res 44(1):41\u20134","journal-title":"J Pineal Res"},{"issue":"4","key":"1751_CR81","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1007\/s11154-009-9117-5","volume":"10","author":"A Korkmaz","year":"2009","unstructured":"Korkmaz A, Topal T, Tan D-X, Reiter RJ (2009) Role of melatonin in metabolic regulation. Rev Endocr Metab Dis 10(4):261\u201370","journal-title":"Rev Endocr Metab Dis"},{"issue":"4","key":"1751_CR82","doi-asserted-by":"publisher","first-page":"219","DOI":"10.2478\/v10102-009-0020-4","volume":"2","author":"A Korkmaz","year":"2009","unstructured":"Korkmaz A, Oter S, Seyrek M, Topal T (2009) Molecular, genetic and epigenetic pathways of peroxynitrite-induced cellular toxicity. Interdiscip Toxicol 2(4):219","journal-title":"Interdiscip Toxicol"},{"issue":"1","key":"1751_CR83","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.gene.2012.04.040","volume":"503","author":"A Korkmaz","year":"2012","unstructured":"Korkmaz A, Rosales-Corral S, Reiter RJ (2012) Gene regulation by melatonin linked to epigenetic phenomena. Gene 503(1):1\u201311","journal-title":"Gene"},{"issue":"2","key":"1751_CR84","doi-asserted-by":"publisher","first-page":"128","DOI":"10.1016\/j.mce.2011.10.013","volume":"349","author":"A Korkmaz","year":"2012","unstructured":"Korkmaz A, Ma S, Topal T, Rosales-Corral S, Tan D-X, Reiter RJ (2012) Glucose: a vital toxin and potential utility of melatonin in protecting against the diabetic state. Mol Cell Endocrinol 349(2):128\u201337","journal-title":"Mol Cell Endocrinol"},{"key":"1751_CR85","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1016\/j.critrevonc.2017.12.018","volume":"122","author":"P Kubatka","year":"2018","unstructured":"Kubatka P, Zubor P, Busselberg D, Kwon TK, Adamek M, Petrovic D et al (2018) Melatonin and breast cancer: evidences from preclinical and human studies. Crit Rev Oncol Hematol 122:133\u201343","journal-title":"Crit Rev Oncol Hematol"},{"issue":"3","key":"1751_CR86","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s41419-018-0383-6","volume":"9","author":"K Kucharewicz","year":"2018","unstructured":"Kucharewicz K, Dudkowska M, Zawadzka A, Ogrodnik M, Szczepankiewicz AA, Czarnocki Z et al (2018) Simultaneous induction and blockade of autophagy by a single agent. Cell Death Dis 9(3):1\u201315","journal-title":"Cell Death Dis"},{"issue":"4","key":"1751_CR87","doi-asserted-by":"publisher","first-page":"353","DOI":"10.1007\/s13206-011-5409-4","volume":"5","author":"SE Lee","year":"2011","unstructured":"Lee SE, Kim SJ, Yang H, Jeong SI, Hwang SY, Park C-S et al (2011) Molecular analysis of melatonin-induced changes in breast cancer cells: microarray study of anti-cancer effect of melatonin. BioChip J 5(4):353\u201361","journal-title":"BioChip J"},{"issue":"7","key":"1751_CR88","doi-asserted-by":"publisher","first-page":"11941","DOI":"10.3390\/ijms150711941","volume":"15","author":"Y-J Lee","year":"2014","unstructured":"Lee Y-J, Lee J-H, Moon J-H, Park S-Y (2014) Overcoming hypoxic-resistance of tumor cells to TRAIL-induced apoptosis through melatonin. Int J Mol Sci 15(7):11941\u201356","journal-title":"Int J Mol Sci"},{"issue":"2","key":"1751_CR89","doi-asserted-by":"publisher","first-page":"dju403","DOI":"10.1093\/jnci\/dju403","volume":"107","author":"BS Lee","year":"2015","unstructured":"Lee BS, Cho YW, Kim GC, Lee DH, Kim CJ, Kil HS et al (2015) Induced phenotype targeted therapy: radiation-induced apoptosis-targeted chemotherapy. J Natl Cancer Inst 107(2):dju403","journal-title":"J Natl Cancer Inst"},{"issue":"6","key":"1751_CR90","doi-asserted-by":"publisher","first-page":"1237","DOI":"10.1016\/j.cell.2013.02.014","volume":"152","author":"I Lee Tong","year":"2013","unstructured":"Lee Tong I, Young RA (2013) Transcriptional regulation and its misregulation in disease. Cell 152(6):1237\u201351","journal-title":"Cell"},{"issue":"4","key":"1751_CR91","doi-asserted-by":"publisher","first-page":"415","DOI":"10.1111\/jpi.12131","volume":"56","author":"J Le\u00f3n","year":"2014","unstructured":"Le\u00f3n J, Casado J, Jim\u00e9nez Ruiz SM, Zurita MS, Gonz\u00e1lez-Puga C, Rej\u00f3n JD et al (2014) Melatonin reduces endothelin-1 expression and secretion in colon cancer cells through the inactivation of FoxO-1 and NF-\u03ba\u03b2. J Pineal Res 56(4):415\u201326","journal-title":"J Pineal Res"},{"issue":"9","key":"1751_CR92","doi-asserted-by":"publisher","first-page":"528","DOI":"10.1038\/nrc.2017.53","volume":"17","author":"JMM Levy","year":"2017","unstructured":"Levy JMM, Towers CG, Thorburn A (2017) Targeting autophagy in cancer. Nat Rev Cancer 17(9):528\u201342","journal-title":"Nat Rev Cancer"},{"issue":"4","key":"1751_CR93","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0122083","volume":"10","author":"M Li","year":"2015","unstructured":"Li M, Yang Z, Vollmer LL, Gao Y, Fu Y, Liu C et al (2015) AMDE-1 is a dual function chemical for autophagy activation and inhibition. PLoS One 10(4):e0122083","journal-title":"PLoS One"},{"issue":"3","key":"1751_CR94","doi-asserted-by":"publisher","first-page":"353","DOI":"10.1111\/jpi.12353","volume":"61","author":"M Li","year":"2016","unstructured":"Li M, Pi H, Yang Z, Reiter RJ, Xu S, Chen X et al (2016) Melatonin antagonizes cadmium-induced neurotoxicity by activating the transcription factor EB-dependent autophagy\u2013lysosome machinery in mouse neuroblastoma cells. J Pineal Res 61(3):353\u201369","journal-title":"J Pineal Res"},{"issue":"24","key":"1751_CR95","doi-asserted-by":"publisher","first-page":"39896","DOI":"10.18632\/oncotarget.16379","volume":"8","author":"Y Li","year":"2017","unstructured":"Li Y, Li S, Zhou Y, Meng X, Zhang J-J, Xu D-P et al (2017) Melatonin for the prevention and treatment of cancer. Oncotarget 8(24):39896","journal-title":"Oncotarget"},{"issue":"4","key":"1751_CR96","doi-asserted-by":"publisher","first-page":"2737","DOI":"10.3892\/ol.2017.5785","volume":"13","author":"W Li","year":"2017","unstructured":"Li W, Wang Z, Chen Y, Wang K, Lu T, Ying F et al (2017) Melatonin treatment induces apoptosis through regulating the nuclear factor-\u03baB and mitogen-activated protein kinase signaling pathways in human gastric cancer SGC7901 cells. Oncol Lett 13(4):2737\u201344","journal-title":"Oncol Lett"},{"issue":"9","key":"1751_CR97","doi-asserted-by":"publisher","first-page":"681","DOI":"10.1080\/15384047.2017.1360442","volume":"18","author":"M-Y Li","year":"2017","unstructured":"Li M-Y, Liu J-Q, Chen D-P, Li Z-Y, Qi B, He L et al (2017) Radiotherapy induces cell cycle arrest and cell apoptosis in nasopharyngeal carcinoma via the ATM and Smad pathways. Cancer Biol Therapy 18(9):681\u201393","journal-title":"Cancer Biol Therapy"},{"issue":"22","key":"1751_CR98","doi-asserted-by":"publisher","first-page":"8742","DOI":"10.1158\/0008-5472.CAN-09-1541","volume":"69","author":"S Liu","year":"2009","unstructured":"Liu S, Goldstein RH, Scepansky EM, Rosenblatt M (2009) Inhibition of rho-associated kinase signaling prevents breast cancer metastasis to human bone. Cancer Res 69(22):8742\u201351","journal-title":"Cancer Res"},{"issue":"2","key":"1751_CR99","doi-asserted-by":"publisher","first-page":"394","DOI":"10.1016\/j.intimp.2011.12.012","volume":"12","author":"C Liu","year":"2012","unstructured":"Liu C, Jia Z, Zhang X, Hou J, Wang L, Hao S et al (2012) Involvement of melatonin in autophagy-mediated mouse hepatoma H22 cell survival. Int Immunopharm 12(2):394\u2013401","journal-title":"Int Immunopharm"},{"issue":"6","key":"1751_CR100","doi-asserted-by":"publisher","first-page":"2297","DOI":"10.1159\/000447922","volume":"39","author":"L Liu","year":"2016","unstructured":"Liu L, Xu Y, Reiter RJ, Pan Y, Chen D, Liu Y et al (2016) Inhibition of ERK1\/2 signaling pathway is involved in melatonin\u2019s antiproliferative effect on human MG-63 osteosarcoma cells. Cell Physiol Biochem 39(6):2297\u2013307","journal-title":"Cell Physiol Biochem"},{"issue":"34","key":"1751_CR101","doi-asserted-by":"publisher","first-page":"21342","DOI":"10.1039\/C7RA02113E","volume":"7","author":"F Long","year":"2017","unstructured":"Long F, Dong C, Jiang K, Xu Y, Chi X, Sun D et al (2017) Melatonin enhances the anti-tumor effect of sorafenib via AKT\/p27-mediated cell cycle arrest in hepatocarcinoma cell lines. RSC Adv 7(34):21342\u201351","journal-title":"RSC Adv"},{"issue":"10","key":"1751_CR102","doi-asserted-by":"publisher","first-page":"e2432","DOI":"10.1038\/cddis.2016.330","volume":"7","author":"Y-X Lu","year":"2016","unstructured":"Lu Y-X, Chen D-L, Wang D-S, Chen L-Z, Mo H-Y, Sheng H et al (2016) Melatonin enhances sensitivity to fluorouracil in oesophageal squamous cell carcinoma through inhibition of Erk and Akt pathway. Cell Death Dis 7(10):e2432","journal-title":"Cell Death Dis"},{"issue":"2","key":"1751_CR103","doi-asserted-by":"publisher","first-page":"606","DOI":"10.1002\/med.21628","volume":"40","author":"N Ma","year":"2020","unstructured":"Ma N, Zhang J, Reiter RJ, Ma X (2020) Melatonin mediates mucosal immune cells, microbial metabolism, and rhythm crosstalk: a therapeutic target to reduce intestinal inflammation. Med Res Rev 40(2):606\u201332","journal-title":"Med Res Rev"},{"issue":"5435","key":"1751_CR104","first-page":"2023","volume":"15","author":"H Maghsoudi","year":"2023","unstructured":"Maghsoudi H, Sheikhnia F, Sitarek P, Hajmalek N, Hassani S, Rashidi V et al (2023) The potential preventive and therapeutic roles of NSAIDs in prostate cancer. Cancers 15(5435):2023","journal-title":"Cancers"},{"issue":"22","key":"1751_CR105","doi-asserted-by":"publisher","first-page":"5435","DOI":"10.3390\/cancers15225435","volume":"15","author":"H Maghsoudi","year":"2023","unstructured":"Maghsoudi H, Sheikhnia F, Sitarek P, Hajmalek N, Hassani S, Rashidi V et al (2023) The potential preventive and therapeutic roles of NSAIDs in prostate cancer. Cancers 15(22):5435","journal-title":"Cancers"},{"issue":"01","key":"1751_CR106","first-page":"13","volume":"67","author":"M Majidinia","year":"2017","unstructured":"Majidinia M, Alizadeh E, Yousefi B, Akbarzadeh M, Mihanfar A, Rahmati-Yamchi M et al (2017) Co-inhibition of notch and nf-\u03bab signaling pathway decreases proliferation through downregulating i\u03bab-\u03b1 and hes-1 expression in human ovarian cancer OVCAR-3 cells. Drug Res 67(01):13\u20139","journal-title":"Drug Res"},{"key":"1751_CR107","doi-asserted-by":"publisher","first-page":"198","DOI":"10.1016\/j.arr.2018.07.010","volume":"47","author":"M Majidinia","year":"2018","unstructured":"Majidinia M, Reiter RJ, Shakouri SK, Yousefi B (2018) The role of melatonin, a multitasking molecule, in retarding the processes of ageing. Age Res Rev 47:198\u2013213","journal-title":"Age Res Rev"},{"issue":"2","key":"1751_CR108","first-page":"46","volume":"6","author":"S Malhotra","year":"2004","unstructured":"Malhotra S, Sawhney G, Pandhi P (2004) The therapeutic potential of melatonin: a review of the science. Medscape Gen Med 6(2):46","journal-title":"Medscape Gen Med"},{"issue":"3","key":"1751_CR109","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1038\/nrc2602","volume":"9","author":"M Malumbres","year":"2009","unstructured":"Malumbres M, Barbacid M (2009) Cell cycle, CDKs and cancer: a changing paradigm. Nat Rev Cancer 9(3):153\u201366","journal-title":"Nat Rev Cancer"},{"issue":"36","key":"1751_CR110","doi-asserted-by":"publisher","first-page":"24435","DOI":"10.1074\/jbc.M801738200","volume":"283","author":"R Mamillapalli","year":"2008","unstructured":"Mamillapalli R, VanHouten J, Zawalich W, Wysolmerski J (2008) Switching of G-protein usage by the calcium-sensing receptor reverses its effect on parathyroid hormone-related protein secretion in normal versus malignant breast cells. J Biol Chem 283(36):24435\u201347","journal-title":"J Biol Chem"},{"issue":"2","key":"1751_CR111","doi-asserted-by":"publisher","first-page":"216","DOI":"10.1016\/j.canlet.2009.06.016","volume":"287","author":"V Mart\u00edn","year":"2010","unstructured":"Mart\u00edn V, Garc\u00eda-Santos G, Rodriguez-Blanco J, Casado-Zapico S, Sanchez-Sanchez A, Antol\u00edn I et al (2010) Melatonin sensitizes human malignant glioma cells against TRAIL-induced cell death. Cancer Lett 287(2):216\u201323","journal-title":"Cancer Lett"},{"issue":"3","key":"1751_CR112","doi-asserted-by":"publisher","first-page":"308","DOI":"10.1111\/jpi.12170","volume":"57","author":"V Mart\u00edn","year":"2014","unstructured":"Mart\u00edn V, Sanchez-Sanchez AM, Puente-Moncada N, Gomez-Lobo M, Alvarez-Vega MA, Antol\u00edn I et al (2014) Involvement of autophagy in melatonin-induced cytotoxicity in glioma-initiating cells. J Pineal Res 57(3):308\u201316","journal-title":"J Pineal Res"},{"issue":"4","key":"1751_CR113","doi-asserted-by":"publisher","first-page":"532","DOI":"10.1111\/j.1600-079X.2008.00641.x","volume":"45","author":"J Mart\u00edn-Renedo","year":"2008","unstructured":"Mart\u00edn-Renedo J, Mauriz JL, Jorquera F, Ruiz-Andr\u00e9s O, Gonz\u00e1lez P, Gonz\u00e1lez-Gallego J (2008) Melatonin induces cell cycle arrest and apoptosis in hepatocarcinoma HepG2 cell line. J Pineal Res 45(4):532\u201340","journal-title":"J Pineal Res"},{"issue":"36","key":"1751_CR114","doi-asserted-by":"publisher","first-page":"4462","DOI":"10.2174\/092986710794183015","volume":"17","author":"DM Mediavilla","year":"2010","unstructured":"Mediavilla DM, Sanchez-Barcelo JE, Tan XD, Manchester L, Reiter JR (2010) Basic mechanisms involved in the anti-cancer effects of melatonin. Curr Med Chem 17(36):4462\u201381","journal-title":"Curr Med Chem"},{"issue":"4","key":"1751_CR115","doi-asserted-by":"publisher","first-page":"360","DOI":"10.1111\/j.1600-079X.2005.00258.x","volume":"39","author":"E Mills","year":"2005","unstructured":"Mills E, Wu P, Seely D, Guyatt G (2005) Melatonin in the treatment of cancer: a systematic review of randomized controlled trials and meta-analysis. J Pineal Res 39(4):360\u20136","journal-title":"J Pineal Res"},{"issue":"1","key":"1751_CR116","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1002\/cbf.3672","volume":"40","author":"SM Mir","year":"2022","unstructured":"Mir SM, Aliarab A, Goodarzi G, Shirzad M, Jafari SM, Qujeq D et al (2022) Melatonin: a smart molecule in the DNA repair system. Cell Biochem Funct 40(1):4\u201316","journal-title":"Cell Biochem Funct"},{"issue":"10","key":"1751_CR117","doi-asserted-by":"publisher","first-page":"17011","DOI":"10.1002\/jcp.28435","volume":"234","author":"M Mirza-Aghazadeh-Attari","year":"2019","unstructured":"Mirza-Aghazadeh-Attari M, Mohammadzadeh A, Adib A, Darband SG, Sadighparvar S, Mihanfar A et al (2019) Melatonin-mediated regulation of autophagy: making sense of double-edged sword in cancer. J Cell Physiol 234(10):17011\u201322","journal-title":"J Cell Physiol"},{"key":"1751_CR118","doi-asserted-by":"publisher","first-page":"228","DOI":"10.1016\/j.lfs.2019.05.009","volume":"228","author":"K Mortezaee","year":"2019","unstructured":"Mortezaee K, Najafi M, Farhood B, Ahmadi A, Potes Y, Shabeeb D et al (2019) Modulation of apoptosis by melatonin for improving cancer treatment efficiency: an updated review. Life Sci 228:228\u201341","journal-title":"Life Sci"},{"key":"1751_CR119","doi-asserted-by":"crossref","unstructured":"Nagelkerke A, Bussink J, Geurts-Moespot A, Sweep FC, Span PN (2015) Therapeutic targeting of autophagy in cancer. Part II: pharmacological modulation of treatment-induced autophagy. Seminars in cancer biology. Elsevier","DOI":"10.1016\/j.semcancer.2014.06.001"},{"issue":"2","key":"1751_CR120","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1016\/j.cell.2008.07.002","volume":"134","author":"Y Nakahata","year":"2008","unstructured":"Nakahata Y, Kaluzova M, Grimaldi B, Sahar S, Hirayama J, Chen D et al (2008) The NAD+-dependent deacetylase SIRT1 modulates CLOCK-mediated chromatin remodeling and circadian control. Cell 134(2):329\u201340","journal-title":"Cell"},{"key":"1751_CR121","doi-asserted-by":"publisher","DOI":"10.1016\/j.msec.2020.111554","volume":"119","author":"G Niu","year":"2021","unstructured":"Niu G, Yousefi B, Qujeq D, Marjani A, Asadi J, Wang Z et al (2021) Melatonin and doxorubicin co-delivered via a functionalized graphene-dendrimeric system enhances apoptosis of osteosarcoma cells. Mater Sci Eng C 119:111554","journal-title":"Mater Sci Eng C"},{"key":"1751_CR122","doi-asserted-by":"publisher","first-page":"456","DOI":"10.1016\/j.biopha.2016.07.004","volume":"83","author":"E Nooshinfar","year":"2016","unstructured":"Nooshinfar E, Bashash D, Safaroghli-Azar A, Bayati S, Rezaei-Tavirani M, Ghaffari SH et al (2016) Melatonin promotes ATO-induced apoptosis in MCF-7 cells: proposing novel therapeutic potential for breast cancer. Biomed Pharm 83:456\u201365","journal-title":"Biomed Pharm"},{"issue":"1","key":"1751_CR123","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1007\/s12282-016-0690-7","volume":"24","author":"E Nooshinfar","year":"2017","unstructured":"Nooshinfar E, Safaroghli-Azar A, Bashash D, Akbari ME (2017) Melatonin, an inhibitory agent in breast cancer. Breast Cancer 24(1):42\u201351","journal-title":"Breast Cancer"},{"issue":"1","key":"1751_CR124","doi-asserted-by":"publisher","DOI":"10.1111\/jpi.12407","volume":"63","author":"C Nopparat","year":"2017","unstructured":"Nopparat C, Sinjanakhom P, Govitrapong P (2017) Melatonin reverses H2O2-induced senescence in SH-SY 5Y cells by enhancing autophagy via sirtuin 1 deacetylation of the RelA\/p65 subunit of NF-\u03baB. J Pineal Res 63(1):e12407","journal-title":"J Pineal Res"},{"key":"1751_CR125","doi-asserted-by":"publisher","first-page":"402","DOI":"10.3389\/fendo.2018.00402","volume":"9","author":"J O'Brien","year":"2018","unstructured":"O\u2019Brien J, Hayder H, Zayed Y, Peng C (2018) Overview of MicroRNA biogenesis, mechanisms of actions, and circulation. Front Endocrinol 9:402","journal-title":"Front Endocrinol"},{"key":"1751_CR126","doi-asserted-by":"crossref","unstructured":"Oishi A, Cecon E, Jockers R (2018) Chapter two-melatonin receptor signaling: impact of receptor oligomerization on receptor function. In: (Shukla AK ed). International review of cell and molecular biology. 338, Academic Press. pp 59\u201377","DOI":"10.1016\/bs.ircmb.2018.02.002"},{"issue":"1","key":"1751_CR127","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1111\/jpi.12102","volume":"56","author":"EJ Park","year":"2014","unstructured":"Park EJ, Woo SM, Min KJ, Kwon TK (2014) Transcriptional and post-translational regulation of Bim controls apoptosis in melatonin-treated human renal cancer Caki cells. J Pineal Res 56(1):97\u2013106","journal-title":"J Pineal Res"},{"issue":"3","key":"1751_CR128","doi-asserted-by":"publisher","first-page":"460","DOI":"10.1089\/ars.2013.5371","volume":"20","author":"KR Parzych","year":"2014","unstructured":"Parzych KR, Klionsky DJ (2014) An overview of autophagy: morphology, mechanism, and regulation. Antioxid Redox Sign 20(3):460\u201373","journal-title":"Antioxid Redox Sign"},{"issue":"2","key":"1751_CR129","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1111\/jpi.12062","volume":"55","author":"J Perdomo","year":"2013","unstructured":"Perdomo J, Cabrera J, Est\u00e9vez F, Loro J, Reiter RJ, Quintana J (2013) Melatonin induces apoptosis through a caspase-dependent but reactive oxygen species-independent mechanism in human leukemia Molt-3 cells. J Pineal Res 55(2):195\u2013206","journal-title":"J Pineal Res"},{"issue":"1","key":"1751_CR130","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1111\/j.1600-079X.2007.00548.x","volume":"45","author":"JG Pizarro","year":"2008","unstructured":"Pizarro JG, Yeste-Velasco M, Esparza JL, Verdaguer E, Pall\u00e0s M, Camins A et al (2008) The antiproliferative activity of melatonin in B65 rat dopaminergic neuroblastoma cells is related to the downregulation of cell cycle-related genes. J Pineal Res 45(1):8\u201316","journal-title":"J Pineal Res"},{"issue":"3","key":"1751_CR131","doi-asserted-by":"publisher","first-page":"396","DOI":"10.1111\/jpi.12358","volume":"61","author":"N Prieto-Dom\u00ednguez","year":"2016","unstructured":"Prieto-Dom\u00ednguez N, Ord\u00f3\u00f1ez R, Fern\u00e1ndez A, M\u00e9ndez-Blanco C, Baulies A, Garcia-Ruiz C et al (2016) Melatonin-induced increase in sensitivity of human hepatocellular carcinoma cells to sorafenib is associated with reactive oxygen species production and mitophagy. J Pin Res 61(3):396\u2013407","journal-title":"J Pin Res"},{"issue":"6","key":"1751_CR132","first-page":"1616","volume":"15","author":"E Ramos","year":"2023","unstructured":"Ramos E, Egea J, L\u00f3pez-Mu\u00f1oz F, Gil-Mart\u00edn E, Romero A (2023) Therapeutic potential of melatonin counteracting chemotherapy-induced toxicity in breast cancer patients: a systematic review. Pharm 15(6):1616","journal-title":"Pharm"},{"key":"1751_CR133","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1016\/j.lfs.2017.08.029","volume":"188","author":"P Ravanan","year":"2017","unstructured":"Ravanan P, Srikumar IF, Talwar P (2017) Autophagy: The spotlight for cellular stress responses. Life Sci 188:53\u201367","journal-title":"Life Sci"},{"issue":"3","key":"1751_CR134","doi-asserted-by":"publisher","first-page":"465","DOI":"10.1111\/pcmr.12227","volume":"27","author":"VW Rebecca","year":"2014","unstructured":"Rebecca VW, Massaro RR, Fedorenko IV, Sondak VK, Anderson AR, Kim E et al (2014) Inhibition of autophagy enhances the effects of the AKT inhibitor MK-2206 when combined with paclitaxel and carboplatin in BRAF wild-type melanoma. Pigment Cell Melanoma Res 27(3):465\u201378","journal-title":"Pigment Cell Melanoma Res"},{"issue":"3","key":"1751_CR135","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1111\/j.1600-079X.2004.00165.x","volume":"37","author":"RJ Reiter","year":"2004","unstructured":"Reiter RJ (2004) Mechanisms of cancer inhibition by melatonin. J Pineal Res 37(3):213\u20134","journal-title":"J Pineal Res"},{"issue":"4","key":"1751_CR136","doi-asserted-by":"publisher","first-page":"843","DOI":"10.3390\/ijms18040843","volume":"18","author":"RJ Reiter","year":"2017","unstructured":"Reiter RJ, Rosales-Corral SA, Tan D-X, Acuna-Castroviejo D, Qin L, Yang S-F et al (2017) Melatonin, a full service anti-cancer agent: inhibition of initiation, progression and metastasis. Int J Mol Sci 18(4):843","journal-title":"Int J Mol Sci"},{"issue":"1","key":"1751_CR137","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1111\/j.1600-079X.2012.01017.x","volume":"54","author":"A Rodriguez-Garcia","year":"2013","unstructured":"Rodriguez-Garcia A, Mayo JC, Hevia D, Quiros-Gonzalez I, Navarro M, Sainz RM (2013) Phenotypic changes caused by melatonin increased sensitivity of prostate cancer cells to cytokine-induced apoptosis. J Pineal Res 54(1):33\u201345","journal-title":"J Pineal Res"},{"issue":"5","key":"1751_CR138","doi-asserted-by":"publisher","first-page":"499","DOI":"10.1007\/s40520-013-0118-6","volume":"25","author":"M Rondanelli","year":"2013","unstructured":"Rondanelli M, Faliva MA, Perna S, Antoniello N (2013) Update on the role of melatonin in the prevention of cancer tumorigenesis and in the management of cancer correlates, such as sleep-wake and mood disturbances: review and remarks. Aging Clin Exper Res 25(5):499\u2013510","journal-title":"Aging Clin Exper Res"},{"key":"1751_CR139","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1016\/j.phrs.2018.01.022","volume":"133","author":"A Roohbakhsh","year":"2018","unstructured":"Roohbakhsh A, Shamsizadeh A, Hayes AW, Reiter RJ, Karimi G (2018) Melatonin as an endogenous regulator of diseases: the role of autophagy. Pharmacol Res 133:265\u201376","journal-title":"Pharmacol Res"},{"key":"1751_CR140","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1007\/978-3-642-25950-0_2","volume":"2013","author":"S Sahar","year":"2013","unstructured":"Sahar S, Sassone-Corsi P (2013) The epigenetic language of circadian clocks. Circ Clocks 2013:29\u201344","journal-title":"Circ Clocks"},{"issue":"7","key":"1751_CR141","doi-asserted-by":"publisher","first-page":"1407","DOI":"10.1007\/s00018-003-2319-1","volume":"60","author":"R Sainz","year":"2003","unstructured":"Sainz R, Mayo J, Rodriguez C, Tan D, Lopez-Burillo S, Reiter R (2003) Melatonin and cell death: differential actions on apoptosis in normal and cancer cells. Cell Mol Life Sci CMLS 60(7):1407\u201326","journal-title":"Cell Mol Life Sci CMLS"},{"key":"1751_CR142","doi-asserted-by":"crossref","unstructured":"San\u2010Miguel B, Crespo I, S\u00e1nchez DI, Gonz\u00e1lez\u2010Fern\u00e1ndez B, Ortiz de Urbina JJ, Tu\u00f1\u00f3n MJ, et al. (2015) Melatonin inhibits autophagy and endoplasmic reticulum stress in mice with carbon tetrachloride\u2010induced fibrosis. J Pineal Res 59(2): 151\u2013162","DOI":"10.1111\/jpi.12247"},{"issue":"9","key":"1751_CR143","doi-asserted-by":"publisher","first-page":"1249","DOI":"10.2119\/molmed.2012.00077","volume":"18","author":"C Savvidis","year":"2012","unstructured":"Savvidis C, Koutsilieris M (2012) Circadian rhythm disruption in cancer biology. Mol Med 18(9):1249\u201360","journal-title":"Mol Med"},{"key":"1751_CR144","doi-asserted-by":"publisher","first-page":"412","DOI":"10.2741\/s276","volume":"4","author":"AH Schonthal","year":"2012","unstructured":"Schonthal AH (2012) Targeting endoplasmic reticulum stress for cancer therapy. Front Biosci (Schol Ed) 4:412\u201331","journal-title":"Front Biosci (Schol Ed)"},{"issue":"3","key":"1751_CR145","doi-asserted-by":"publisher","first-page":"277","DOI":"10.1111\/j.1600-079X.2008.00587.x","volume":"45","author":"R Sharma","year":"2008","unstructured":"Sharma R, Ottenhof T, Rzeczkowska PA, Niles LP (2008) Epigenetic targets for melatonin: induction of histone H3 hyperacetylation and gene expression in C17.2 neural stem cells. J Pineal Res 45(3):277\u201384","journal-title":"J Pineal Res"},{"key":"1751_CR146","doi-asserted-by":"publisher","first-page":"601","DOI":"10.2174\/1389557523666230825144150","volume":"24","author":"F Sheikhnia","year":"2023","unstructured":"Sheikhnia F, Maghsoudi H, Majidinia M (2023) The critical function of microRNAs in developing resistance against 5-fluorouracil in cancer cells. Mini Rev Med Chem 24:601\u2013617","journal-title":"Mini Rev Med Chem"},{"issue":"1","key":"1751_CR147","doi-asserted-by":"publisher","first-page":"320","DOI":"10.1186\/s12935-023-03174-4","volume":"23","author":"F Sheikhnia","year":"2023","unstructured":"Sheikhnia F, Rashidi V, Maghsoudi H, Majidinia M (2023) Potential anticancer properties and mechanisms of thymoquinone in colorectal cancer. Cancer Cell Int 23(1):320","journal-title":"Cancer Cell Int"},{"issue":"2","key":"1751_CR148","doi-asserted-by":"publisher","first-page":"176","DOI":"10.3390\/ijms17020176","volume":"17","author":"C-J Shen","year":"2016","unstructured":"Shen C-J, Chang C-C, Chen Y-T, Lai C-S, Hsu Y-C (2016) Melatonin suppresses the growth of ovarian cancer cell lines (OVCAR-429 and PA-1) and potentiates the effect of G1 arrest by targeting CDKs. Int J Mol Sci 17(2):176","journal-title":"Int J Mol Sci"},{"issue":"3","key":"1751_CR149","doi-asserted-by":"publisher","DOI":"10.1111\/jpi.12461","volume":"64","author":"YQ Shen","year":"2018","unstructured":"Shen YQ, Guerra-Librero A, Fernandez-Gil BI, Florido J, Garc\u00eda-L\u00f3pez S, Martinez-Ruiz L et al (2018) Combination of melatonin and rapamycin for head and neck cancer therapy: suppression of AKT\/mTOR pathway activation, and activation of mitophagy and apoptosis via mitochondrial function regulation. J Pineal Res 64(3):e12461","journal-title":"J Pineal Res"},{"key":"1751_CR150","doi-asserted-by":"publisher","first-page":"138","DOI":"10.1016\/j.redox.2018.07.004","volume":"18","author":"M Shen","year":"2018","unstructured":"Shen M, Cao Y, Jiang Y, Wei Y, Liu H (2018) Melatonin protects mouse granulosa cells against oxidative damage by inhibiting FOXO1-mediated autophagy: implication of an antioxidation-independent mechanism. Redox Biol 18:138\u201357","journal-title":"Redox Biol"},{"issue":"1","key":"1751_CR151","doi-asserted-by":"publisher","first-page":"7","DOI":"10.3322\/caac.21551","volume":"69","author":"RL Siegel","year":"2019","unstructured":"Siegel RL, Miller KD, Jemal A (2019) Cancer statistics,2019. CA Cancer J Clin 69(1):7\u201334","journal-title":"CA Cancer J Clin"},{"issue":"3","key":"1751_CR152","doi-asserted-by":"publisher","first-page":"490","DOI":"10.1016\/j.jid.2017.10.025","volume":"138","author":"AT Slominski","year":"2018","unstructured":"Slominski AT, Hardeland R, Zmijewski MA, Slominski RM, Reiter RJ, Paus R (2018) Melatonin: a cutaneous perspective on its production, metabolism, and functions. J Invest Dermatol 138(3):490\u20139","journal-title":"J Invest Dermatol"},{"issue":"1","key":"1751_CR153","doi-asserted-by":"publisher","first-page":"19","DOI":"10.7150\/jca.9591","volume":"6","author":"EJ Sohn","year":"2015","unstructured":"Sohn EJ, Won G, Lee J, Lee S, Kim SH (2015) Upregulation of miRNA3195 and miRNA374b mediates the anti-angiogenic properties of melatonin in hypoxic PC-3 prostate cancer cells. J Cancer 6(1):19\u201328","journal-title":"J Cancer"},{"issue":"4","key":"1751_CR154","doi-asserted-by":"publisher","first-page":"335","DOI":"10.1111\/j.1600-079X.2012.01003.x","volume":"53","author":"N Song","year":"2012","unstructured":"Song N, Kim AJ, Kim HJ, Jee HJ, Kim M, Yoo YH et al (2012) Melatonin suppresses doxorubicin-induced premature senescence of A549 lung cancer cells by ameliorating mitochondrial dysfunction. J Pineal Res 53(4):335\u201343","journal-title":"J Pineal Res"},{"issue":"4","key":"1751_CR155","first-page":"1975","volume":"39","author":"J Song","year":"2018","unstructured":"Song J, Ma S-J, Luo J-H, Zhang H, Wang R-X, Liu H et al (2018) Melatonin induces the apoptosis and inhibits the proliferation of human gastric cancer cells via blockade of the AKT\/MDM2 pathway. Oncol Rep 39(4):1975\u201383","journal-title":"Oncol Rep"},{"issue":"4","key":"1751_CR156","first-page":"1975","volume":"39","author":"J Song","year":"2018","unstructured":"Song J, Ma S-J, Luo J-H, Zhang H, Wang R-X, Liu H et al (2018) Melatonin induces the apoptosis and inhibits the proliferation of human gastric cancer cells via blockade of the AKT\/MDM2 pathway. Oncology Rep 39(4):1975\u201383","journal-title":"Oncology Rep"},{"issue":"3","key":"1751_CR157","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1177\/1534735408322846","volume":"7","author":"V Srinivasan","year":"2008","unstructured":"Srinivasan V, Spence DW, Pandi-Perumal SR, Trakht I, Cardinali DP (2008) Therapeutic actions of melatonin in cancer: possible mechanisms. Integr Cancer Therap 7(3):189\u2013203","journal-title":"Integr Cancer Therap"},{"issue":"3","key":"1751_CR158","doi-asserted-by":"publisher","DOI":"10.1111\/jpi.12556","volume":"66","author":"GJ Sung","year":"2019","unstructured":"Sung GJ, Kim SH, Kwak S, Park SH, Song JH, Jung JH et al (2019) Inhibition of TFEB oligomerization by co-treatment of melatonin with vorinostat promotes the therapeutic sensitivity in glioblastoma and glioma stem cells. J Pineal Res 66(3):e12556","journal-title":"J Pineal Res"},{"issue":"3","key":"1751_CR159","doi-asserted-by":"publisher","first-page":"209","DOI":"10.3322\/caac.21660","volume":"71","author":"H Sung","year":"2021","unstructured":"Sung H, Ferlay J, Siegel RL, Laversanne M, Soerjomataram I, Jemal A et al (2021) Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin 71(3):209\u201349","journal-title":"CA Cancer J Clin"},{"issue":"1","key":"1751_CR160","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1111\/j.1600-079X.2010.00812.x","volume":"50","author":"S Swarnakar","year":"2011","unstructured":"Swarnakar S, Paul S, Singh LP, Reiter RJ (2011) Matrix metalloproteinases in health and disease: regulation by melatonin. J Pineal Res 50(1):8\u201320","journal-title":"J Pineal Res"},{"issue":"2","key":"1751_CR161","doi-asserted-by":"publisher","first-page":"659","DOI":"10.3390\/ijerph17020659","volume":"17","author":"M Szkiela","year":"2020","unstructured":"Szkiela M, Kuside\u0142 E, Makowiec-D\u0105browska T, Kaleta D (2020) Night shift work\u2014a risk factor for breast cancer. Int J Environ Res Public Health 17(2):659","journal-title":"Int J Environ Res Public Health"},{"issue":"9","key":"1751_CR162","doi-asserted-by":"publisher","first-page":"2506","DOI":"10.3390\/molecules26092506","volume":"26","author":"WH Talib","year":"2021","unstructured":"Talib WH, Alsayed AR, Abuawad A, Daoud S, Mahmod AI (2021) Melatonin in cancer treatment: current knowledge and future opportunities. Molecules 26(9):2506","journal-title":"Molecules"},{"issue":"5","key":"1751_CR163","doi-asserted-by":"publisher","first-page":"5372","DOI":"10.1002\/jcp.27372","volume":"234","author":"OR Tamtaji","year":"2019","unstructured":"Tamtaji OR, Mirhosseini N, Reiter RJ, Behnamfar M, Asemi Z (2019) Melatonin and pancreatic cancer: current knowledge and future perspectives. J Cell Physiol 234(5):5372\u20138","journal-title":"J Cell Physiol"},{"key":"1751_CR164","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1016\/j.biochi.2022.06.008","volume":"202","author":"N Targhazeh","year":"2022","unstructured":"Targhazeh N, Reiter RJ, Rahimi M, Qujeq D, Yousefi T, Shahavi MH et al (2022) Oncostatic activities of melatonin: roles in cell cycle, apoptosis, and autophagy. Biochimie 202:34\u201348","journal-title":"Biochimie"},{"key":"1751_CR165","doi-asserted-by":"publisher","first-page":"285","DOI":"10.1016\/bs.ircmb.2019.11.001","volume":"350","author":"A Thangaraj","year":"2020","unstructured":"Thangaraj A, Sil S, Tripathi A, Chivero ET, Periyasamy P, Buch S (2020) Targeting endoplasmic reticulum stress and autophagy as therapeutic approaches for neurological diseases. Int Rev Cell Mol Biol 350:285\u2013325","journal-title":"Int Rev Cell Mol Biol"},{"issue":"6","key":"1751_CR166","doi-asserted-by":"publisher","first-page":"1433","DOI":"10.1016\/j.cell.2016.11.023","volume":"167","author":"SA Tooze","year":"2016","unstructured":"Tooze SA, Dikic I (2016) Autophagy captures the nobel prize. Cell 167(6):1433\u20135","journal-title":"Cell"},{"issue":"3","key":"1751_CR167","doi-asserted-by":"publisher","first-page":"434","DOI":"10.2174\/1570159X14666161228122115","volume":"15","author":"S Tordjman","year":"2017","unstructured":"Tordjman S, Chokron S, Delorme R, Charrier A, Bellissant E, Jaafari N et al (2017) Melatonin: pharmacology, functions and therapeutic benefits. Current neuropharmacology 15(3):434\u201343","journal-title":"Current neuropharmacology"},{"key":"1751_CR168","unstructured":"TORK O, Eltablawy N (2013) The effect of melatonin on cisplatin induced-kidney injury in rats: possible role of autophagy"},{"issue":"3","key":"1751_CR169","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1002\/mc.22274","volume":"55","author":"P Trivedi","year":"2016","unstructured":"Trivedi P, Jena G, Tikoo K, Kumar V (2016) Melatonin modulated autophagy and Nrf2 signaling pathways in mice with colitis-associated colon carcinogenesis. Mol Carcinog 55(3):255\u201367","journal-title":"Mol Carcinog"},{"issue":"1","key":"1751_CR170","doi-asserted-by":"publisher","first-page":"80","DOI":"10.1111\/j.1600-079X.2011.00922.x","volume":"52","author":"I Vega-Naredo","year":"2012","unstructured":"Vega-Naredo I, Caballero B, Sierra V, Garc\u00eda-Macia M, de Gonzalo-Calvo D, Oliveira PJ et al (2012) Melatonin modulates autophagy through a redox-mediated action in female Syrian hamster Harderian gland controlling cell types and gland activity. J Pineal Res 52(1):80\u201392","journal-title":"J Pineal Res"},{"issue":"7","key":"1751_CR171","doi-asserted-by":"publisher","first-page":"3779","DOI":"10.3390\/ijms23073779","volume":"23","author":"L Wang","year":"2022","unstructured":"Wang L, Wang C, Choi WS (2022) Use of melatonin in cancer treatment: Where are we? Int J Mol Sci 23(7):3779","journal-title":"Int J Mol Sci"},{"issue":"8","key":"1751_CR172","doi-asserted-by":"publisher","first-page":"6723","DOI":"10.1002\/jcb.26864","volume":"119","author":"X Wei","year":"2018","unstructured":"Wei X, Qi Y, Jia N, Zhou Q, Zhang S, Wang Y (2018) Hyperbaric oxygen treatment sensitizes gastric cancer cells to melatonin-induced apoptosis through multiple pathways. J Cell Biochem 119(8):6723\u201331","journal-title":"J Cell Biochem"},{"issue":"2","key":"1751_CR173","doi-asserted-by":"publisher","DOI":"10.1111\/jpi.12668","volume":"69","author":"YC Wen","year":"2020","unstructured":"Wen YC, Lin YW, Chu CY, Yang YC, Yang SF, Liu YF et al (2020) Melatonin-triggered post-transcriptional and post-translational modifications of ADAMTS1 coordinately retard tumorigenesis and metastasis of renal cell carcinoma. J Pineal Res 69(2):e12668","journal-title":"J Pineal Res"},{"issue":"1","key":"1751_CR174","first-page":"1","volume":"32","author":"ES Wenzel","year":"2018","unstructured":"Wenzel ES, Singh AT (2018) Cell-cycle checkpoints and aneuploidy on the path to cancer. In Vivo 32(1):1\u20135","journal-title":"In Vivo"},{"issue":"4","key":"1751_CR175","doi-asserted-by":"publisher","first-page":"705","DOI":"10.1080\/15548627.2016.1144005","volume":"12","author":"NP Whitehead","year":"2016","unstructured":"Whitehead NP (2016) Enhanced autophagy as a potential mechanism for the improved physiological function by simvastatin in muscular dystrophy. Autophagy 12(4):705\u20136","journal-title":"Autophagy"},{"key":"1751_CR176","doi-asserted-by":"publisher","first-page":"1514","DOI":"10.1902\/jop.2008.080172","volume":"79","author":"AG Wilson","year":"2008","unstructured":"Wilson AG (2008) Epigenetic regulation of gene expression in the inflammatory response and relevance to common diseases. J Periodontol 79:1514\u20139","journal-title":"J Periodontol"},{"issue":"16","key":"1751_CR177","doi-asserted-by":"publisher","first-page":"21952","DOI":"10.18632\/oncotarget.8009","volume":"7","author":"CM Yeh","year":"2016","unstructured":"Yeh CM, Lin CW, Yang JS, Yang WE, Su SC, Yang SF (2016) Melatonin inhibits TPA-induced oral cancer cell migration by suppressing matrix metalloproteinase-9 activation through the histone acetylation. Oncotarget 7(16):21952\u201367","journal-title":"Oncotarget"},{"key":"1751_CR178","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2024.113548","volume":"143","author":"T Yousefi","year":"2024","unstructured":"Yousefi T, Memar MY, Jazi AA, Zand S, Reiter RJ, Amirkhanlou S et al (2024) Molecular pathways and biological roles of melatonin and vitamin D; effects on immune system and oxidative stress. Int Immunopharm 143:113548","journal-title":"Int Immunopharm"},{"issue":"1","key":"1751_CR179","doi-asserted-by":"publisher","DOI":"10.1111\/jpi.12478","volume":"65","author":"Z Yu","year":"2018","unstructured":"Yu Z, Tian X, Peng Y, Sun Z, Wang C, Tang N et al (2018) Mitochondrial cytochrome P450 (CYP) 1B1 is responsible for melatonin-induced apoptosis in neural cancer cells. J Pineal Res 65(1):e12478","journal-title":"J Pineal Res"},{"key":"1751_CR180","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1016\/j.mce.2015.11.016","volume":"422","author":"S-M Yun","year":"2016","unstructured":"Yun S-M, Woo SH, Oh ST, Hong S-E, Choe T-B, Ye S-K et al (2016) Melatonin enhances arsenic trioxide-induced cell death via sustained upregulation of Redd1 expression in breast cancer cells. Mol Cell Endocrinol 422:64\u201373","journal-title":"Mol Cell Endocrinol"},{"issue":"7","key":"1751_CR181","doi-asserted-by":"publisher","first-page":"3951","DOI":"10.21873\/anticanres.12681","volume":"38","author":"CW Yun","year":"2018","unstructured":"Yun CW, Kim S, Lee JH, Lee SH (2018) Melatonin promotes apoptosis of colorectal cancer cells via superoxide-mediated ER stress by inhibiting cellular prion protein expression. Anticancer Res 38(7):3951\u201360","journal-title":"Anticancer Res"},{"issue":"3","key":"1751_CR182","doi-asserted-by":"publisher","first-page":"383","DOI":"10.1016\/S1734-1140(09)70081-7","volume":"61","author":"JB Zawilska","year":"2009","unstructured":"Zawilska JB, Skene DJ, Arendt J (2009) Physiology and pharmacology of melatonin in relation to biological rhythms. Pharmacol Rep 61(3):383\u2013410","journal-title":"Pharmacol Rep"},{"issue":"7","key":"1751_CR183","doi-asserted-by":"publisher","first-page":"831","DOI":"10.7150\/jca.14573","volume":"7","author":"M Zhao","year":"2016","unstructured":"Zhao M, Wan J, Zeng K, Tong M, Lee AC, Ding J et al (2016) The reduction in circulating melatonin level may contribute to the pathogenesis of ovarian cancer: a retrospective study. J Cancer 7(7):831","journal-title":"J Cancer"},{"issue":"3","key":"1751_CR184","doi-asserted-by":"publisher","first-page":"156","DOI":"10.3390\/nu8030156","volume":"8","author":"Y Zhou","year":"2016","unstructured":"Zhou Y, Li Y, Zhou T, Zheng J, Li S, Li H-B (2016) Dietary natural products for prevention and treatment of liver cancer. Nutrients 8(3):156","journal-title":"Nutrients"},{"issue":"4","key":"1751_CR185","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0175122","volume":"12","author":"Y Zhou","year":"2017","unstructured":"Zhou Y, Zhang X, Zhang J, Fang J, Ge Z, Li X (2017) LRG1 promotes proliferation and inhibits apoptosis in colorectal cancer cells via RUNX1 activation. PLOS One 12(4):e0175122","journal-title":"PLOS One"}],"container-title":["Inflammopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10787-025-01751-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10787-025-01751-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10787-025-01751-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,18]],"date-time":"2025-06-18T03:02:39Z","timestamp":1750215759000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10787-025-01751-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4,22]]},"references-count":185,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2025,5]]}},"alternative-id":["1751"],"URL":"https:\/\/doi.org\/10.1007\/s10787-025-01751-9","relation":{},"ISSN":["0925-4692","1568-5608"],"issn-type":[{"value":"0925-4692","type":"print"},{"value":"1568-5608","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,4,22]]},"assertion":[{"value":"6 December 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 April 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 April 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interest"}}]}}