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This study aimed to evaluate the soothing and wound-healing effects of fixed and volatile oils of\n                    <jats:italic>Boswellia sarca<\/jats:italic>\n                    , as well as extracts of\n                    <jats:italic>Glycyrrhiza glabra<\/jats:italic>\n                    and\n                    <jats:italic>Acacia nilotica<\/jats:italic>\n                    , on acute contact dermatitis in rats. Phytochemical analysis revealed the presence of flavonoids, tannins, saponins, triterpenoids, alkaloids, and cardiac glycosides in\n                    <jats:italic>Acacia nilotica<\/jats:italic>\n                    and,\n                    <jats:italic>Glycyrrhiza glabra<\/jats:italic>\n                    extracts, with\n                    <jats:italic>Boswellia sarca<\/jats:italic>\n                    showing a dominance of volatile oils. The study included a normal group and six acute allergic dermatitis groups induced by subcutaneous histamine injection. One group served as a positive control without treatment, while five groups were treated topically at inflamed sites with\n                    <jats:italic>Boswellia sarca<\/jats:italic>\n                    oils,\n                    <jats:italic>Glycyrrhiza glabra<\/jats:italic>\n                    , and\n                    <jats:italic>Acacia nilotica<\/jats:italic>\n                    extracts, alongside betamethasone as a standard treatment. The effects were evaluated through inspection, serum levels of ICAM-1, LTB4, and IL\u03b2-4, as well as histopathological and immunohistochemical analyses. GC\/MS analysis identified Incensole acetate (50.12%) and Incensole (32.44%) as major compounds in\n                    <jats:italic>BS<\/jats:italic>\n                    fixed oil, with significant terpenoids and volatile components. Metabolomic profiling using LC-MS\/MS highlighted diverse secondary metabolites in\n                    <jats:italic>Acacia nilotica<\/jats:italic>\n                    and,\n                    <jats:italic>Glycyrrhiza glabra<\/jats:italic>\n                    , including polyphenolic acids, flavonoids, and amino acids, showcasing their therapeutic potential. All topical treatments reduced ICAM-1 and LTB4 levels to varying degrees and exhibited better histopathological and immunohistochemical results compared to the untreated positive control group. Among the treatments,\n                    <jats:italic>Boswellia<\/jats:italic>\n                    oils and,\n                    <jats:italic>Glycyrrhiza glabra<\/jats:italic>\n                    extracts demonstrated the most effective soothing and curative effects on allergic dermatitis.\n                    <jats:italic>Boswellia sarca<\/jats:italic>\n                    oils and,\n                    <jats:italic>Glycyrrhiza glabra<\/jats:italic>\n                    extract showed the best soothing and curative effects against allergic dermatitis.\n                  <\/jats:p>","DOI":"10.1007\/s10787-025-01761-7","type":"journal-article","created":{"date-parts":[[2025,5,19]],"date-time":"2025-05-19T14:41:14Z","timestamp":1747665674000},"page":"2793-2814","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["A pharmaco-metabolomics study of Glycyrrhiza glabra, Boswellia sarca, and Acacia nilotica in acute allergic dermatitis"],"prefix":"10.1007","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4668-9811","authenticated-orcid":false,"given":"Bassant M. 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