{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T01:30:27Z","timestamp":1792287027252,"version":"4.4.0"},"reference-count":179,"publisher":"Springer Science and Business Media LLC","license":[{"start":{"date-parts":[[2025,5,8]],"date-time":"2025-05-08T00:00:00Z","timestamp":1746662400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2025,5,8]],"date-time":"2025-05-08T00:00:00Z","timestamp":1746662400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100002386","name":"Cairo University","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100002386","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Inflammopharmacol"],"abstract":"<jats:title>Abstract<\/jats:title>\n          <jats:p>Ototoxicity, the property of certain drugs to cause hearing loss, is a significant concern in medical treatments, particularly with the use of chemotherapeutic agents like cisplatin and aminoglycosides. These drugs can lead to permanent sensorineural hearing loss (SNHL), affecting a substantial proportion of patients. Existing strategies to alleviate these side effects are limited, prompting interest in natural products as potential protective agents. Natural products are being investigated for their ability to counteract these mechanisms through anti-inflammatory and antioxidant properties. The review seeks to highlight the potential of these natural products as complementary therapies to conventional ototoxic medications, emphasizing their protective roles, which are involved in cochlear cellular damage and programmed cell death. Further research is essential to establish standardized protocols for their use and to ensure their integration into clinical practice as effective therapeutic options.<\/jats:p>","DOI":"10.1007\/s10787-025-01766-2","type":"journal-article","created":{"date-parts":[[2025,5,8]],"date-time":"2025-05-08T07:18:54Z","timestamp":1746688734000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["A comprehensive review of the impact of natural products in preventing drug-induced ototoxicity"],"prefix":"10.1007","author":[{"given":"Rania S.","family":"Salah","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asmaa A.","family":"Mahmoud","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3179-3352","authenticated-orcid":false,"given":"Riham A.","family":"El-Shiekh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmed M.","family":"El-Dessouki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abrar Gomaa Abd-Elfattah","family":"Hassan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samar S.","family":"Khalaf","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,5,8]]},"reference":[{"key":"1766_CR1","doi-asserted-by":"publisher","first-page":"1461823","DOI":"10.3389\/fneur.2024.1461823","volume":"15","author":"AA Adeyemo","year":"2024","unstructured":"Adeyemo AA, Adeolu J, Akinyemi JO, Omotade OO, Oluwatosin OM (2024) Predictive model for aminoglycoside induced ototoxicity. Front Neurol 15:1461823","journal-title":"Front Neurol"},{"issue":"2","key":"1766_CR2","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1016\/j.tips.2008.11.002","volume":"30","author":"BB Aggarwal","year":"2009","unstructured":"Aggarwal BB, Sung B (2009) Pharmacological basis for the role of curcumin in chronic diseases: an age-old spice with modern targets. Trends Pharmacol Sci 30(2):85\u201394","journal-title":"Trends Pharmacol Sci"},{"key":"1766_CR3","unstructured":"Alberti PW (2001) The anatomy and physiology of the ear and hearing. Occupational exposure to noise: Evaluation, prevention, and control, 53\u201362."},{"issue":"3","key":"1766_CR4","doi-asserted-by":"publisher","first-page":"141","DOI":"10.4103\/indianjotol.INDIANJOTOL_129_20","volume":"26","author":"EE Altuntas","year":"2020","unstructured":"Altuntas EE, Durmus K, Bora A, Turgut NH, Terzi H, Kutluhan A (2020) Examination of ototoxicity induced by imatinib, being a tyrosine kinase inhibitor: an experimental study. Indian J Otol 26(3):141\u2013146","journal-title":"Indian J Otol"},{"key":"1766_CR5","doi-asserted-by":"publisher","DOI":"10.54393\/pbmj.v6i10.894","author":"S Arshad","year":"2023","unstructured":"Arshad S, Kanwal A, Ijaz M, Maqbool S, Ilyas T (2023) Nocturnal leg cramps in young adults: nocturnal leg cramps. Pakistan BioMed J. https:\/\/doi.org\/10.54393\/pbmj.v6i10.894","journal-title":"Pakistan BioMed J"},{"issue":"26","key":"1766_CR6","doi-asserted-by":"publisher","first-page":"10151","DOI":"10.1021\/jf061809j","volume":"54","author":"OB Ashton","year":"2006","unstructured":"Ashton OB, Wong M, Mcghie TK, Vather R, Wang Y, Requejo-Jackman C, Ramankutty P, Woolf AB (2006) Pigments in avocado tissue and oil. J Agric Food Chem 54(26):10151\u201310158","journal-title":"J Agric Food Chem"},{"key":"1766_CR7","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1016\/j.ijporl.2019.04.003","volume":"122","author":"NGY Asl\u0131er","year":"2019","unstructured":"Asl\u0131er NGY, Ta\u011fa\u00e7 AA, Durankaya SM, \u00c7al\u0131\u015f\u0131r M, Ersoy N, K\u0131rk\u0131m G, Yurdako\u00e7 K, Ba\u011fr\u0131yan\u0131k HA, Y\u0131lmaz O, S\u00fctay S (2019) Dexamethasone-loaded chitosan-based genipin-cross-linked hydrogel for prevention of cisplatin induced ototoxicity in Guinea pig model. Int J Pediatr Otorhinolaryngol 122:60\u201369","journal-title":"Int J Pediatr Otorhinolaryngol"},{"issue":"3","key":"1766_CR8","doi-asserted-by":"publisher","first-page":"290","DOI":"10.5152\/iao.2016.2617","volume":"12","author":"D Avci","year":"2016","unstructured":"Avci D, Erkan M, S\u00f6nmez MF, K\u00f6koglu K, G\u00fcnes MS, G\u00fcndogdu R, G\u00fcle\u00e7 S, Karabulut D (2016) A prospective experimental study on the protective effect of resveratrol against amikacin-induced ototoxicity in rats. J Int Adv Otol 12(3):290","journal-title":"J Int Adv Otol"},{"issue":"3","key":"1766_CR9","doi-asserted-by":"publisher","first-page":"785","DOI":"10.1007\/s00439-021-02303-1","volume":"141","author":"P Bahena","year":"2022","unstructured":"Bahena P, Daftarian N, Maroofian R, Linares P, Villalobos D, Mirrahimi M, Rad A, Doll J, Hofrichter MA, Koparir A (2022) Unraveling the genetic complexities of combined retinal dystrophy and hearing impairment. Hum Genet 141(3):785\u2013803","journal-title":"Hum Genet"},{"issue":"03","key":"1766_CR10","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1016\/j.wjorl.2021.01.005","volume":"8","author":"X Bai","year":"2022","unstructured":"Bai X, Wang M, Niu X, Yu H, Yue J-X, Sun Y (2022) Effect of N-acetyl-cysteine treatment on sensorineural hearing loss: a meta-analysis. World J Otorhinolaryngol Head Neck Surg 8(03):205\u2013212","journal-title":"World J Otorhinolaryngol Head Neck Surg"},{"key":"1766_CR11","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2022.912647","volume":"13","author":"M Barbara","year":"2022","unstructured":"Barbara M, Margani V, Covelli E, Filippi C, Volpini L, El-Borady OM, El-Kemary M, Elzayat S, Elfarargy HH (2022) The Use of Nanoparticles in Otoprotection. Front Neurol 13:912647","journal-title":"Front Neurol"},{"key":"1766_CR12","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1044\/2022_AJA-21-00252","volume":"32","author":"G Basura","year":"2023","unstructured":"Basura G, Cienkowski K, Hamlin L, Ray C, Rutherford C, Stamper G, Schooling T, Ambrose J (2023) American speech-language-hearing association clinical practice guideline on aural rehabilitation for adults with hearing loss. Am J Audiol 32:1\u201351","journal-title":"Am J Audiol"},{"key":"1766_CR13","first-page":"721","volume":"5","author":"I Bellezza","year":"1865","unstructured":"Bellezza I, Giambanco I, Minelli A, Donato R (1865) (2018) Nrf2-Keap1 signaling in oxidative and reductive stress. Biochim Biophys Acta 5:721\u2013733","journal-title":"Biochim Biophys Acta"},{"issue":"10","key":"1766_CR14","doi-asserted-by":"publisher","first-page":"570","DOI":"10.1177\/014556130808701010","volume":"87","author":"S Bonabi","year":"2008","unstructured":"Bonabi S, Caelers A, Monge A, Huber A, Bodmer D (2008) Resveratrol protects auditory hair cells from gentamicin toxicity. Ear Nose Throat J 87(10):570\u2013573","journal-title":"Ear Nose Throat J"},{"issue":"7","key":"1766_CR15","doi-asserted-by":"publisher","first-page":"e2921","DOI":"10.1038\/cddis.2017.314","volume":"8","author":"V Borse","year":"2017","unstructured":"Borse V, Al Aameri RF, Sheehan K, Sheth S, Kaur T, Mukherjea D, Tupal S, Lowy M, Ghosh S, Dhukhwa A (2017) Epigallocatechin-3-gallate, a prototypic chemopreventative agent for protection against cisplatin-based ototoxicity. Cell Death Dis 8(7):e2921\u2013e2921","journal-title":"Cell Death Dis"},{"key":"1766_CR16","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1016\/j.heares.2013.01.006","volume":"303","author":"EC B\u00f6ttger","year":"2013","unstructured":"B\u00f6ttger EC, Schacht J (2013) The mitochondrion: a perpetrator of acquired hearing loss. Hear Res 303:12\u201319","journal-title":"Hear Res"},{"issue":"3","key":"1766_CR17","doi-asserted-by":"publisher","first-page":"246","DOI":"10.1177\/0049475520917236","volume":"50","author":"H Brough","year":"2020","unstructured":"Brough H (2020) Acquired auditory neuropathy spectrum disorder after malaria treated with quinine. Trop Doct 50(3):246\u2013248","journal-title":"Trop Doct"},{"issue":"11","key":"1766_CR18","doi-asserted-by":"publisher","first-page":"1097","DOI":"10.1017\/S0022215112002046","volume":"126","author":"B Cakil","year":"2012","unstructured":"Cakil B, Basar FS, Atmaca S, Cengel SK, Tekat A, Tanyeri Y (2012) The protective effect of Ginkgo biloba extract against experimental cisplatin ototoxicity: animal research using distortion product otoacoustic emissions. J Laryngol Otol 126(11):1097\u20131101","journal-title":"J Laryngol Otol"},{"issue":"4","key":"1766_CR19","doi-asserted-by":"publisher","first-page":"166","DOI":"10.3109\/21695717.2014.964939","volume":"12","author":"E Cannizzaro","year":"2014","unstructured":"Cannizzaro E, Cannizzaro C, Plescia F, Martines F, Soleo L, Pira E, Lo Coco D (2014) Exposure to ototoxic agents and hearing loss: a review of current knowledge. Hear Balance Commun 12(4):166\u2013175","journal-title":"Hear Balance Commun"},{"key":"1766_CR20","doi-asserted-by":"publisher","first-page":"409","DOI":"10.1016\/j.jep.2018.11.016","volume":"231","author":"R Castaneda","year":"2019","unstructured":"Castaneda R, Natarajan S, Jeong SY, Hong BN, Kang TH (2019) Traditional oriental medicine for sensorineural hearing loss: Can ethnopharmacology contribute to potential drug discovery? J Ethnopharmacol 231:409\u2013428","journal-title":"J Ethnopharmacol"},{"issue":"4","key":"1766_CR21","first-page":"115","volume":"32","author":"MD \u00c7evikkan","year":"2022","unstructured":"\u00c7evikkan MD, Aslan A, Uluer ET, Tas DD (2022) Investigation of ototoxicity of intratympanic 5-fluorouracil in rats. Turk J Ear Nose Throat 32(4):115\u2013120","journal-title":"Turk J Ear Nose Throat"},{"issue":"4","key":"1766_CR22","doi-asserted-by":"publisher","first-page":"242","DOI":"10.2471\/BLT.21.285643","volume":"99","author":"S Chadha","year":"2021","unstructured":"Chadha S, Kamenov K, Cieza A (2021) The world report on hearing, 2021. Bull World Health Organ 99(4):242","journal-title":"Bull World Health Organ"},{"issue":"5","key":"1766_CR23","doi-asserted-by":"publisher","first-page":"278","DOI":"10.1200\/OP.22.00710","volume":"19","author":"A Chattaraj","year":"2023","unstructured":"Chattaraj A, Syed MP, Low CA, Owonikoko TK (2023) Cisplatin-Induced Ototoxicity: a concise review of the burden, prevention, and interception strategies. JCO Oncol Pract 19(5):278\u2013283","journal-title":"JCO Oncol Pract"},{"issue":"8","key":"1766_CR24","doi-asserted-by":"publisher","first-page":"e2118895","DOI":"10.1001\/jamanetworkopen.2021.18895","volume":"4","author":"C-H Chen","year":"2021","unstructured":"Chen C-H, Huang C-Y, Lin H-YH, Wang M-C, Chang C-Y, Cheng Y-F (2021) Association of sodium thiosulfate with risk of ototoxic effects from platinum-based chemotherapy: a systematic review and meta-analysis. JAMA Netw Open 4(8):e2118895\u2013e2118895","journal-title":"JAMA Netw Open"},{"issue":"6","key":"1766_CR25","doi-asserted-by":"publisher","first-page":"980","DOI":"10.1111\/bph.13397","volume":"173","author":"HI Cho","year":"2016","unstructured":"Cho HI, Kim SJ, Choi JW, Lee SM (2016) Genipin alleviates sepsis-induced liver injury by restoring autophagy. Br J Pharmacol 173(6):980\u2013991","journal-title":"Br J Pharmacol"},{"key":"1766_CR26","doi-asserted-by":"publisher","DOI":"10.1016\/j.heares.2020.108019","volume":"395","author":"SN Davis","year":"2020","unstructured":"Davis SN, Wu P, Camci ED, Simon JA, Rubel EW, Raible DW (2020) Chloroquine kills hair cells in zebrafish lateral line and murine cochlear cultures: implications for ototoxicity. Hear Res 395:108019","journal-title":"Hear Res"},{"issue":"10","key":"1766_CR27","doi-asserted-by":"publisher","first-page":"2209","DOI":"10.1016\/j.ajem.2020.07.030","volume":"38","author":"A Della Porta","year":"2020","unstructured":"Della Porta A, Bornstein K, Coye A, Montrief T, Long B, Parris MA (2020) Acute chloroquine and hydroxychloroquine toxicity: a review for emergency clinicians. Am J Emerg Med 38(10):2209\u20132217","journal-title":"Am J Emerg Med"},{"issue":"2","key":"1766_CR28","doi-asserted-by":"publisher","first-page":"806","DOI":"10.3892\/ijmm.2020.4633","volume":"46","author":"Y Di","year":"2020","unstructured":"Di Y, Xu T, Tian Y, Ma T, Qu D, Wang Y, Lin Y, Bao D, Yu L, Liu S (2020) Ursolic acid protects against cisplatin-induced ototoxicity by inhibiting oxidative stress and TRPV1-mediated Ca2+-signaling. Int J Mol Med 46(2):806\u2013816","journal-title":"Int J Mol Med"},{"issue":"2","key":"1766_CR29","doi-asserted-by":"publisher","first-page":"12","DOI":"10.5935\/0946-5448.20150003","volume":"19","author":"MA Dias","year":"2015","unstructured":"Dias MA, Sampaio ALL, de Alencar Meneses E, Oliveira CACP (2015) The chemopreventive effect of Ginkgo biloba extract 761 against cisplatin ototoxicity: a pilot study. Int Tinnitus J 19(2):12\u201319","journal-title":"Int Tinnitus J"},{"issue":"4","key":"1766_CR30","doi-asserted-by":"publisher","first-page":"dlab184","DOI":"10.1093\/jacamr\/dlab184","volume":"3","author":"F Diepstraten","year":"2021","unstructured":"Diepstraten F, Hoetink A, Van Grotel M, Huitema A, Stokroos R, van den Heuvel-Eibrink M, Meijer A (2021) Aminoglycoside-and glycopeptide-induced ototoxicity in children: a systematic review. JAC Antimicrob Resist 3(4):dlab184","journal-title":"JAC Antimicrob Resist"},{"key":"1766_CR31","doi-asserted-by":"publisher","DOI":"10.1016\/j.canep.2022.102203","volume":"79","author":"LK Dillard","year":"2022","unstructured":"Dillard LK, Lopez-Perez L, Martinez RX, Fullerton AM, Chadha S, McMahon CM (2022) Global burden of ototoxic hearing loss associated with platinum-based cancer treatment: a systematic review and meta-analysis. Cancer Epidemiol 79:102203","journal-title":"Cancer Epidemiol"},{"issue":"2","key":"1766_CR32","first-page":"696","volume":"27","author":"B Dincer","year":"2023","unstructured":"Dincer B, Atalay F, Tatar A (2023a) Zingiberene attenuates paclitaxel-induced ototoxicity by strengthening cochlear antioxidant defense system in vivo. J Res Pharm 27(2):696\u2013704","journal-title":"J Res Pharm"},{"issue":"4","key":"1766_CR33","doi-asserted-by":"publisher","first-page":"753","DOI":"10.33808\/clinexphealthsci.1130449","volume":"13","author":"B Dincer","year":"2023","unstructured":"Dincer B, Atalay F, Tatar AJC, Sciences EH (2023b) Otoprotective mechanisms of carvone as an antioxidant agent against ototoxic damage caused by paclitaxel. Clin Exp Health Sci 13(4):753\u2013759","journal-title":"Clin Exp Health Sci"},{"issue":"4","key":"1766_CR34","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1016\/j.joto.2016.10.001","volume":"11","author":"D Ding","year":"2016","unstructured":"Ding D, Liu H, Qi W, Jiang H, Li Y, Wu X, Sun H, Gross K, Salvi R (2016) Ototoxic effects and mechanisms of loop diuretics. Journal of Otology 11(4):145\u2013156","journal-title":"Journal of Otology"},{"key":"1766_CR35","doi-asserted-by":"publisher","DOI":"10.3389\/fnmol.2022.829642","volume":"15","author":"H Du","year":"2022","unstructured":"Du H, Zhou X, Shi L, Xia M, Wang Y, Guo N, Hu H, Zhang P, Yang H, Zhu F (2022) Shikonin attenuates cochlear spiral ganglion neuron degeneration by activating Nrf2-ARE signaling pathway. Front Mol Neurosci 15:829642","journal-title":"Front Mol Neurosci"},{"key":"1766_CR36","doi-asserted-by":"publisher","first-page":"479","DOI":"10.1007\/978-3-031-77370-9_23","volume-title":"Neurotology updates","author":"OK E\u011filmez","year":"2024","unstructured":"E\u011filmez OK, Aksoy F, Kalcioglu MT, Steyger PS (2024) Ototoxicity: cochleotoxicity and vestibulotoxicity. In: Kalcioglu MT, Muluk NB, Jenkins HA (eds) Neurotology updates. Springer, Cham, pp 479\u2013518"},{"key":"1766_CR37","doi-asserted-by":"publisher","first-page":"2185","DOI":"10.1007\/s00405-011-1883-5","volume":"269","author":"T Erdem","year":"2012","unstructured":"Erdem T, Bayindir T, Filiz A, Iraz M, Selimoglu E (2012) The effect of resveratrol on the prevention of cisplatin ototoxicity. Eur Arch Otorhinolaryngol 269:2185\u20132188","journal-title":"Eur Arch Otorhinolaryngol"},{"issue":"9","key":"1766_CR38","doi-asserted-by":"publisher","first-page":"3556","DOI":"10.1172\/JCI84939","volume":"126","author":"R Esterberg","year":"2016","unstructured":"Esterberg R, Linbo T, Pickett SB, Wu P, Ou HC, Rubel EW, Raible DW (2016) Mitochondrial calcium uptake underlies ROS generation during aminoglycoside-induced hair cell death. J Clin Investig 126(9):3556\u20133566","journal-title":"J Clin Investig"},{"issue":"10","key":"1766_CR39","doi-asserted-by":"publisher","first-page":"3025","DOI":"10.4103\/NRR.NRR-D-23-01879","volume":"20","author":"J Fang","year":"2025","unstructured":"Fang J, Li Z, Wang P, Zhang X, Mao S, Li Y, Yu D, Li X, Xing Y, Shi H (2025) Inhibition of the NLRP3 inflammasome attenuates spiral ganglion neuron degeneration in aminoglycoside-induced hearing loss. Neural Regen Res 20(10):3025\u20133039","journal-title":"Neural Regen Res"},{"issue":"01","key":"1766_CR40","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1055\/s-0041-1740986","volume":"26","author":"CP Fernandes","year":"2022","unstructured":"Fernandes CP, Vernier LS, Dallegrave E, Machado MS (2022) The ototoxicity of chloroquine and hydroxychloroquine: a systematic review. Int Arch Otorhinolaryngol 26(01):167\u2013177","journal-title":"Int Arch Otorhinolaryngol"},{"issue":"3","key":"1766_CR41","doi-asserted-by":"publisher","first-page":"586","DOI":"10.3390\/jcm11030586","volume":"11","author":"S Ferreira-Cendon","year":"2022","unstructured":"Ferreira-Cendon S, Martinez-Carranza R, Fernandez-Nava MJ, Villaoslada-Fuente R, Sanchez-Gomez H, Santa Cruz-Ruiz S, Sanchez-Ledesma M, Batuecas-Caletrio A (2022) Prevention of severe vestibular hypofunction after systemic gentamicin. J Clin Med 11(3):586","journal-title":"J Clin Med"},{"issue":"10","key":"1766_CR42","doi-asserted-by":"publisher","first-page":"1434","DOI":"10.1038\/bjc.2015.359","volume":"113","author":"AR Fetoni","year":"2015","unstructured":"Fetoni AR, Paciello F, Mezzogori D, Rolesi R, Eramo SLM, Paludetti G, Troiani D (2015) Molecular targets for anticancer redox chemotherapy and cisplatin-induced ototoxicity: the role of curcumin on pSTAT3 and Nrf-2 signalling. Br J Cancer 113(10):1434\u20131444","journal-title":"Br J Cancer"},{"key":"1766_CR43","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1016\/j.freeradbiomed.2019.02.022","volume":"135","author":"AR Fetoni","year":"2019","unstructured":"Fetoni AR, Paciello F, Rolesi R, Paludetti G, Troiani D (2019) Targeting dysregulation of redox homeostasis in noise-induced hearing loss: oxidative stress and ROS signaling. Free Radical Biol Med 135:46\u201359","journal-title":"Free Radical Biol Med"},{"issue":"8","key":"1766_CR44","doi-asserted-by":"publisher","first-page":"e195","DOI":"10.1038\/cddis.2011.76","volume":"2","author":"S Francis","year":"2011","unstructured":"Francis S, Kramarenko I, Brandon C, Lee F, Baker T, Cunningham L (2011) Celastrol inhibits aminoglycoside-induced ototoxicity via heat shock protein 32. Cell Death Dis 2(8):e195\u2013e195","journal-title":"Cell Death Dis"},{"issue":"2","key":"1766_CR45","doi-asserted-by":"publisher","first-page":"167","DOI":"10.5152\/iao.2022.21416","volume":"18","author":"L Franz","year":"2022","unstructured":"Franz L, Frosolini A, Parrino D, Lovato A, de Filippis C, Marioni G (2022) Ototoxicity of immunosuppressant drugs: a systematic review. J Int Adv Otol 18(2):167","journal-title":"J Int Adv Otol"},{"key":"1766_CR46","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2021.692762","volume":"15","author":"X Fu","year":"2021","unstructured":"Fu X, Wan P, Li P, Wang J, Guo S, Zhang Y, An Y, Ye C, Liu Z, Gao J (2021) Mechanism and prevention of ototoxicity induced by aminoglycosides. Front Cell Neurosci 15:692762","journal-title":"Front Cell Neurosci"},{"issue":"4","key":"1766_CR47","doi-asserted-by":"publisher","first-page":"109","DOI":"10.3390\/antiox8040109","volume":"8","author":"C Fujimoto","year":"2019","unstructured":"Fujimoto C, Yamasoba T (2019) Mitochondria-targeted antioxidants for treatment of hearing loss: a systematic review. Antioxidants 8(4):109","journal-title":"Antioxidants"},{"issue":"24","key":"1766_CR48","doi-asserted-by":"publisher","first-page":"3952","DOI":"10.1002\/cncr.34991","volume":"129","author":"SA Funt","year":"2023","unstructured":"Funt SA, Knezevic A, Wilson K, Bromberg M, Budnick A, O\u2019Connor KL, McHugh DJ, Larsen E, Bajorin DF, Motzer RJ (2023) Ototoxicity associated with high-dose carboplatin for patients with previously treated germ cell tumors. Cancer 129(24):3952\u20133961","journal-title":"Cancer"},{"issue":"3","key":"1766_CR49","doi-asserted-by":"publisher","first-page":"643","DOI":"10.1016\/S0304-4165(99)00152-X","volume":"1472","author":"Z Gao","year":"1999","unstructured":"Gao Z, Huang K, Yang X, Xu H (1999) Free radical scavenging and antioxidant activities of flavonoids extracted from the radix of Scutellaria baicalensis Georgi. Biochim Biophys Acta 1472(3):643\u2013650","journal-title":"Biochim Biophys Acta"},{"key":"1766_CR50","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1016\/j.heares.2017.12.004","volume":"358","author":"F Garcia-Alcantara","year":"2018","unstructured":"Garcia-Alcantara F, Murillo-Cuesta S, Pulido S, Bermudez-Munoz JM, Martinez-Vega R, Milo M, Varela-Nieto I, Rivera T (2018) The expression of oxidative stress response genes is modulated by a combination of resveratrol and N-acetylcysteine to ameliorate ototoxicity in the rat cochlea. Hear Res 358:10\u201321","journal-title":"Hear Res"},{"key":"1766_CR51","doi-asserted-by":"publisher","first-page":"305","DOI":"10.1016\/j.biopha.2017.10.001","volume":"96","author":"A Ghorbani","year":"2017","unstructured":"Ghorbani A (2017) Mechanisms of antidiabetic effects of flavonoid rutin. Biomed Pharmacother 96:305\u2013312","journal-title":"Biomed Pharmacother"},{"key":"1766_CR52","doi-asserted-by":"publisher","DOI":"10.1177\/2473974X221100545","author":"G Gill","year":"2022","unstructured":"Gill G, Blakley BW (2022) Does N-acetylcysteine improve established hearing loss in guinea pigs? OTO Open. https:\/\/doi.org\/10.1177\/2473974X221100545","journal-title":"OTO Open"},{"issue":"8","key":"1766_CR53","doi-asserted-by":"publisher","first-page":"4272","DOI":"10.3390\/ijms25084272","volume":"25","author":"NB Gill","year":"2024","unstructured":"Gill NB, Dowker-Key PD, Hedrick M, Bettaieb A (2024) Unveiling the role of oxidative stress in cochlear hair cell death: prospective phytochemical therapeutics against sensorineural hearing loss. Int J Mol Sci 25(8):4272","journal-title":"Int J Mol Sci"},{"key":"1766_CR54","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/1745-6215-15-110","volume":"15","author":"A Gilles","year":"2014","unstructured":"Gilles A, Ihtijarevic B, Wouters K, Van de Heyning P (2014) Using prophylactic antioxidants to prevent noise-induced hearing damage in young adults: a protocol for a double-blind, randomized controlled trial. Trials 15:1\u20135","journal-title":"Trials"},{"key":"1766_CR55","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s41581-024-00808-2","volume":"20","author":"D Greenberg","year":"2024","unstructured":"Greenberg D, Rosenblum ND, Tonelli M (2024) The multifaceted links between hearing loss and chronic kidney disease. Nat Rev Nephrol 20:1\u201318","journal-title":"Nat Rev Nephrol"},{"key":"1766_CR56","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12951-019-0560-5","volume":"18","author":"J Gu","year":"2020","unstructured":"Gu J, Chen Y, Tong L, Wang X, Yu D, Wu H (2020) Astaxanthin-loaded polymer-lipid hybrid nanoparticles (ATX-LPN): assessment of potential otoprotective effects. J Nanobiotechnol 18:1\u201317","journal-title":"J Nanobiotechnol"},{"issue":"2","key":"1766_CR57","doi-asserted-by":"publisher","first-page":"229","DOI":"10.5152\/iao.2019.5902","volume":"15","author":"R G\u00fcndo\u011fdu","year":"2019","unstructured":"G\u00fcndo\u011fdu R, Erkan M, Ayd\u0131n M, S\u00f6nmez MF, Vural A, K\u00f6ko\u011flu K, Karabulut D, \u015eahin M\u0130 (2019) Assessment of the effectiveness of quercetin on cisplatin-induced ototoxicity in rats. J Int Adv Otol 15(2):229","journal-title":"J Int Adv Otol"},{"issue":"2","key":"1766_CR58","first-page":"25","volume":"20","author":"S Gupta","year":"2019","unstructured":"Gupta S, Singh D (2019) Reviewing all possible causes of ototoxicity and its mechanism. Adv Pharmacol Toxicol 20(2):25","journal-title":"Adv Pharmacol Toxicol"},{"key":"1766_CR59","doi-asserted-by":"publisher","first-page":"1140916","DOI":"10.3389\/fncel.2023.1140916","volume":"17","author":"H Han","year":"2023","unstructured":"Han H, Hu S, Hu Y, Liu D, Zhou J, Liu X, Ma X, Dong Y (2023) Mitophagy in ototoxicity. Front Cell Neurosci 17:1140916","journal-title":"Front Cell Neurosci"},{"issue":"13","key":"1766_CR60","doi-asserted-by":"publisher","first-page":"5512","DOI":"10.1021\/acs.jmedchem.7b01653","volume":"61","author":"RA Hazlitt","year":"2018","unstructured":"Hazlitt RA, Min J, Zuo J (2018) Progress in the development of preventative drugs for cisplatin-induced hearing loss: miniperspective. J Med Chem 61(13):5512\u20135524","journal-title":"J Med Chem"},{"issue":"3","key":"1766_CR61","doi-asserted-by":"publisher","first-page":"600","DOI":"10.1111\/jcmm.13005","volume":"21","author":"Q He","year":"2017","unstructured":"He Q, Jia Z, Zhang Y, Ren X (2017) Morin hydrate promotes inner ear neural stem cell survival and differentiation and protects cochlea against neuronal hearing loss. J Cell Mol Med 21(3):600\u2013608","journal-title":"J Cell Mol Med"},{"key":"1766_CR62","doi-asserted-by":"publisher","DOI":"10.1016\/j.otohns.2010.04.266","author":"S Heman-Ackah","year":"2015","unstructured":"Heman-Ackah S (2015) A combination antioxidant therapy in the treatment and prevention of age related hearing loss. Otolaryngol Head Neck Surg. https:\/\/doi.org\/10.1016\/j.otohns.2010.04.266","journal-title":"Otolaryngol Head Neck Surg"},{"issue":"7","key":"1766_CR63","doi-asserted-by":"publisher","first-page":"1773","DOI":"10.3390\/nu15071773","volume":"15","author":"BN Hong","year":"2023","unstructured":"Hong BN, Shin SW, Nam YH, Shim JH, Kim NW, Kim MC, Nuankaew W, Kwak JH, Kang TH (2023) Amelioration of sensorineural hearing loss through regulation of Trpv1, Cacna1h, and Ngf gene expression by a combination of cuscutae semen and rehmanniae radix preparata. Nutrients 15(7):1773","journal-title":"Nutrients"},{"issue":"1","key":"1766_CR64","doi-asserted-by":"publisher","first-page":"106","DOI":"10.1097\/CM9.0000000000000024","volume":"132","author":"X-J Hu","year":"2019","unstructured":"Hu X-J (2019) Protective capability of Astragalus (Huangqi) on auditory function in a rat model of estrogen deficiency. Chin Med J 132(1):106\u2013108","journal-title":"Chin Med J"},{"key":"1766_CR65","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2021.620741","volume":"12","author":"Y Hu","year":"2021","unstructured":"Hu Y, Ma X (2021) Icariin treatment protects against gentamicin-induced ototoxicity via activation of the AMPK-SIRT3 pathway. Front Pharmacol 12:620741","journal-title":"Front Pharmacol"},{"issue":"1","key":"1766_CR66","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1186\/s13020-023-00825-6","volume":"18","author":"S Hu","year":"2023","unstructured":"Hu S, Sun Q, Xu F, Jiang N, Gao J (2023) Age-related hearing loss and its potential drug candidates: a systematic review. Chin Med 18(1):121","journal-title":"Chin Med"},{"issue":"2","key":"1766_CR67","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1016\/j.canlet.2005.08.025","volume":"239","author":"S-S Huang","year":"2006","unstructured":"Huang S-S, Zheng R-L (2006) Rosmarinic acid inhibits angiogenesis and its mechanism of action in vitro. Cancer Lett 239(2):271\u2013280","journal-title":"Cancer Lett"},{"issue":"10","key":"1766_CR68","doi-asserted-by":"publisher","first-page":"2371","DOI":"10.1271\/bbb.50698","volume":"70","author":"W-H Huang","year":"2006","unstructured":"Huang W-H, Lee A-R, Yang C-H (2006) Antioxidative and anti-inflammatory activities of polyhydroxyflavonoids of Scutellaria baicalensis GEORGI. Biosci Biotechnol Biochem 70(10):2371\u20132380","journal-title":"Biosci Biotechnol Biochem"},{"key":"1766_CR69","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbi.2024.110939","volume":"393","author":"T-L Huang","year":"2024","unstructured":"Huang T-L, Jiang W-J, Zhou Z, Shi T-F, Yu M, Yu M, Si J-Q, Wang Y-P, Li L (2024) Quercetin attenuates cisplatin-induced mitochondrial apoptosis via PI3K\/Akt mediated inhibition of oxidative stress in pericytes and improves the blood labyrinth barrier permeability. Chem Biol Interact 393:110939","journal-title":"Chem Biol Interact"},{"key":"1766_CR70","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2022.980309","volume":"13","author":"EG Hurkmans","year":"2023","unstructured":"Hurkmans EG, Klumpers MJ, Dello Russo C, De Witte W, Guchelaar H-J, Gelderblom H, Cleton-Jansen A-M, Vermeulen SH, Kaal S, van der Graaf WT (2023) Genome-wide analyses of platinum-induced ototoxicity in childhood cancer patients: results of GO-CAT and United Kingdom MAGIC consortia. Front Pharmacol 13:980309","journal-title":"Front Pharmacol"},{"issue":"3S","key":"1766_CR71","doi-asserted-by":"publisher","first-page":"746","DOI":"10.1044\/2023_AJA-22-00199","volume":"32","author":"K Janky","year":"2023","unstructured":"Janky K, Steyger PS (2023) Mechanisms and impact of aminoglycoside-induced vestibular deficits. Am J Audiol 32(3S):746\u2013760","journal-title":"Am J Audiol"},{"issue":"4","key":"1766_CR72","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0018815","volume":"6","author":"H-J Jeong","year":"2011","unstructured":"Jeong H-J, Choi Y, Kim M-H, Kang I-C, Lee J-H, Park C, Park R, Kim H-M (2011) Rosmarinic acid, active component of Dansam-Eum attenuates ototoxicity of cochlear hair cells through blockage of caspase-1 activity. PLoS ONE 6(4):e18815","journal-title":"PLoS ONE"},{"issue":"1","key":"1766_CR73","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1186\/s43046-022-00117-4","volume":"34","author":"N Jose","year":"2022","unstructured":"Jose N, Joel A, Selvakumar RJ, Ramireddy J, John AO, Georgy JT, Singh A, Ram TS (2022) Diagnosis and management of 5-fluorouracil (5-FU)-induced acute leukoencephalopathy: lessons learnt from a single-Centre case series. J Egypt Natl Canc Inst 34(1):22","journal-title":"J Egypt Natl Canc Inst"},{"key":"1766_CR74","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2021.661740","volume":"12","author":"M Jozefowicz-Korczynska","year":"2021","unstructured":"Jozefowicz-Korczynska M, Pajor A, Lucas Grzelczyk W (2021) The ototoxicity of antimalarial drugs\u2014a state of the art review. Front Neurol 12:661740","journal-title":"Front Neurol"},{"key":"1766_CR75","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1016\/j.ijporl.2016.03.019","volume":"85","author":"M Kara","year":"2016","unstructured":"Kara M, T\u00fcrk\u00f6n H, Karaca T, G\u00fc\u00e7l\u00fc O, Uysal S, T\u00fcrky\u0131lmaz M, Demirta\u015f S, Derek\u00f6y FS (2016) Evaluation of the protective effects of hesperetin against cisplatin-induced ototoxicity in a rat animal model. Int J Pediatr Otorhinolaryngol 85:12\u201318","journal-title":"Int J Pediatr Otorhinolaryngol"},{"key":"1766_CR76","doi-asserted-by":"publisher","DOI":"10.3389\/fpubh.2020.00252","author":"AV Kasbekar","year":"2020","unstructured":"Kasbekar AV, Prayuenyong P, Baguley DM (2020) Clinical implications of chloroquine and hydroxychloroquine ototoxicity for COVID-19 treatment: a mini-review. Front Public Health. https:\/\/doi.org\/10.3389\/fpubh.2020.00252","journal-title":"Front Public Health"},{"issue":"9","key":"1766_CR77","doi-asserted-by":"publisher","first-page":"4597","DOI":"10.62347\/OKGQ4382","volume":"14","author":"L Kessler","year":"2024","unstructured":"Kessler L, Koo C, Richter C-P, Tan X (2024) Hearing loss during chemotherapy: prevalence, mechanisms, and protection. Am J Cancer Res 14(9):4597","journal-title":"Am J Cancer Res"},{"issue":"2","key":"1766_CR78","doi-asserted-by":"publisher","first-page":"e142","DOI":"10.1038\/emm.2014.112","volume":"47","author":"S-J Kim","year":"2015","unstructured":"Kim S-J, Ho Hur J, Park C, Kim H-J, Oh G-S, Lee JN, Yoo S-J, Choe S-K, So H-S, Lim DJ (2015) Bucillamine prevents cisplatin-induced ototoxicity through induction of glutathione and antioxidant genes. Exp Mol Med 47(2):e142\u2013e142","journal-title":"Exp Mol Med"},{"key":"1766_CR79","doi-asserted-by":"publisher","first-page":"78","DOI":"10.1016\/j.toxlet.2016.01.005","volume":"245","author":"Y-R Kim","year":"2016","unstructured":"Kim Y-R, Kim M-A, Cho H-J, Oh S-K, Lee I-K, Kim U-K, Lee K-Y (2016) Galangin prevents aminoglycoside-induced ototoxicity by decreasing mitochondrial production of reactive oxygen species in mouse cochlear cultures. Toxicol Lett 245:78\u201385","journal-title":"Toxicol Lett"},{"key":"1766_CR80","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s13258-021-01157-1","volume":"44","author":"J-H Kim","year":"2022","unstructured":"Kim J-H, Baek J-I, Lee I-K, Kim U-K, Kim Y-R, Lee K-Y (2022) Protective effect of berberine chloride against cisplatin-induced ototoxicity. Genes Genomics 44:1\u20137","journal-title":"Genes Genomics"},{"key":"1766_CR81","first-page":"114","volume":"34","author":"LJ Kreeger","year":"2024","unstructured":"Kreeger LJ, Honnuraiah S, Maeker S, Shea S, Fishell G, Goodrich LV (2024) An anatomical and physiological basis for coincidence detection across time scales in the auditory system. bioRxiv 34:114","journal-title":"bioRxiv"},{"issue":"11","key":"1766_CR82","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a033548","volume":"9","author":"CJ Kros","year":"2019","unstructured":"Kros CJ, Steyger PS (2019) Aminoglycoside-and cisplatin-induced ototoxicity: mechanisms and otoprotective strategies. Cold Spring Harb Perspect Med 9(11):a033548","journal-title":"Cold Spring Harb Perspect Med"},{"issue":"1","key":"1766_CR83","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.25281","volume":"102","author":"H Lai","year":"2024","unstructured":"Lai H, Gao M, Yang H (2024) The potassium channels: neurobiology and pharmacology of tinnitus. J Neurosci Res 102(1):e25281","journal-title":"J Neurosci Res"},{"issue":"1","key":"1766_CR84","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1016\/j.ijporl.2014.11.008","volume":"79","author":"SH Lee","year":"2015","unstructured":"Lee SH, Kim HS, An YS, Chang J, Choi J, Im GJ (2015) Protective effect of resveratrol against cisplatin-induced ototoxicity in HEI-OC1 auditory cells. Int J Pediatr Otorhinolaryngol 79(1):58\u201362","journal-title":"Int J Pediatr Otorhinolaryngol"},{"issue":"1","key":"1766_CR85","doi-asserted-by":"publisher","first-page":"12646","DOI":"10.1038\/s41598-019-49133-w","volume":"9","author":"S-H Lee","year":"2019","unstructured":"Lee S-H, Lyu A-R, Shin S-A, Jeong S-H, Lee S-A, Park MJ, Park Y-H (2019) Cochlear glucocorticoid receptor and serum corticosterone expression in a rodent model of noise-induced hearing loss: comparison of timing of dexamethasone administration. Sci Rep 9(1):12646","journal-title":"Sci Rep"},{"issue":"1","key":"1766_CR86","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1146\/annurev-pharmtox-033123-114106","volume":"64","author":"J Lee","year":"2024","unstructured":"Lee J, Fernandez K, Cunningham LL (2024) Hear and now: ongoing clinical trials to prevent drug-induced hearing loss. Annu Rev Pharmacol Toxicol 64(1):211\u2013230","journal-title":"Annu Rev Pharmacol Toxicol"},{"issue":"9","key":"1766_CR87","doi-asserted-by":"publisher","first-page":"4891","DOI":"10.1016\/j.sjbs.2021.06.021","volume":"28","author":"Z Li","year":"2021","unstructured":"Li Z, Wang Y, Zhao J, Zhang H (2021) Dieckol attenuates the nociception and inflammatory responses in different nociceptive and inflammatory induced mice model. Saudi J Biol Sci 28(9):4891\u20134899","journal-title":"Saudi J Biol Sci"},{"issue":"10","key":"1766_CR88","doi-asserted-by":"publisher","first-page":"622","DOI":"10.3390\/md20100622","volume":"20","author":"H Li","year":"2022","unstructured":"Li H, Oh SH, Shin H-C, Suh M-W (2022) Intratympanic administration of dieckol prevents ototoxic hearing loss. Mar Drugs 20(10):622","journal-title":"Mar Drugs"},{"issue":"3","key":"1766_CR89","doi-asserted-by":"publisher","DOI":"10.1002\/brx2.34","volume":"1","author":"L Li","year":"2023","unstructured":"Li L, Chen D, Lin X, Luo J, Tan J, Li P (2023) Understanding the role of inflammation in sensorineural hearing loss: current goals and future prospects. Brain-X 1(3):e34","journal-title":"Brain-X"},{"issue":"21","key":"1766_CR90","doi-asserted-by":"publisher","first-page":"2195","DOI":"10.1001\/jama.2020.17647","volume":"324","author":"JE Lieu","year":"2020","unstructured":"Lieu JE, Kenna M, Anne S, Davidson L (2020) Hearing loss in children: a review. JAMA 324(21):2195\u20132205","journal-title":"JAMA"},{"issue":"10","key":"1766_CR91","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0140346","volume":"10","author":"P Lin","year":"2015","unstructured":"Lin P, Lu J, Wang Y, Gu W, Yu J, Zhao R (2015) Naturally occurring stilbenoid TSG reverses non-alcoholic fatty liver diseases via gut-liver axis. PLoS ONE 10(10):e0140346","journal-title":"PLoS ONE"},{"issue":"2","key":"1766_CR92","doi-asserted-by":"publisher","first-page":"695","DOI":"10.1039\/C6FO01616B","volume":"8","author":"J Liu","year":"2017","unstructured":"Liu J, Tang J (2017) Effects of pomegranate extract in supplementing gonadotropin-releasing hormone therapy on idiopathic central precocious puberty in Chinese girls: a randomized, placebo-controlled, double-blind clinical trial. Food Funct 8(2):695\u2013700","journal-title":"Food Funct"},{"issue":"3","key":"1766_CR93","doi-asserted-by":"publisher","first-page":"385","DOI":"10.1139\/bcb-2020-0459","volume":"99","author":"Y Liu","year":"2021","unstructured":"Liu Y, Wu H, Zhang F, Yang J, He JJB, Biology C (2021) Resveratrol upregulates miR-455\u20135p to antagonize cisplatin ototoxicity via modulating the PTEN\u2013PI3K\u2013AKT axis. Biochem Cell Biol 99(3):385\u2013395","journal-title":"Biochem Cell Biol"},{"issue":"8","key":"1766_CR94","doi-asserted-by":"publisher","first-page":"609","DOI":"10.1002\/ptr.1505","volume":"18","author":"M Long","year":"2004","unstructured":"Long M, Smouha EE, Qiu D, Li F, Johnson F, Luft B (2004) Flavanoid of Drynaria fortunei protects against gentamicin ototoxicity. Phytother Res 18(8):609\u2013614","journal-title":"Phytother Res"},{"key":"1766_CR95","first-page":"1090034","volume":"1","author":"X Lu","year":"2022","unstructured":"Lu X, Deng T, Dong H, Han J, Yu Y, Xiang D, Nie G, Hu B (2022) Novel application of eupatilin for effectively attenuating cisplatin-induced auditory hair cell death via mitochondrial apoptosis pathway. Oxid Med Cell Longev 1:1090034","journal-title":"Oxid Med Cell Longev"},{"key":"1766_CR96","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2024.117174","volume":"178","author":"X Lu","year":"2024","unstructured":"Lu X, Yin N, Chen C, Zhou Y, Ji L, Zhang B, Hu H (2024) Mangiferin alleviates cisplatin-induced ototoxicity in sensorineural hearing loss. Biomed Pharmacother 178:117174","journal-title":"Biomed Pharmacother"},{"key":"1766_CR97","doi-asserted-by":"publisher","first-page":"949","DOI":"10.1007\/s00280-015-2716-9","volume":"75","author":"W Ma","year":"2015","unstructured":"Ma W, Hu J, Cheng Y, Wang J, Zhang X, Xu M (2015) Ginkgolide B protects against cisplatin-induced ototoxicity: enhancement of Akt\u2013Nrf2\u2013HO-1 signaling and reduction of NADPH oxidase. Cancer Chemother Pharmacol 75:949\u2013959","journal-title":"Cancer Chemother Pharmacol"},{"key":"1766_CR98","doi-asserted-by":"publisher","DOI":"10.1590\/s2175-97902019000218311","volume":"55","author":"M-R Mahmoudian-Sani","year":"2019","unstructured":"Mahmoudian-Sani M-R, Sheikhshabani S, Mirfakhar FS, Asgharzade S (2019) A review on medicinal plants used for treating ototoxicity and acoustic trauma induced hearing loss. Braz J Pharm Sci 55:e18311","journal-title":"Braz J Pharm Sci"},{"issue":"7","key":"1766_CR99","doi-asserted-by":"publisher","first-page":"842","DOI":"10.3390\/antiox13070842","volume":"13","author":"A Maniaci","year":"2024","unstructured":"Maniaci A, La Via L, Lechien J, Sangiorgio G, Iannella G, Magliulo G, Pace A, Mat Q, Lavalle S, Lentini M (2024) Hearing loss and oxidative stress: a comprehensive review. Antioxidants 13(7):842","journal-title":"Antioxidants"},{"issue":"4","key":"1766_CR100","doi-asserted-by":"publisher","first-page":"126","DOI":"10.3390\/md16040126","volume":"16","author":"CM Mano","year":"2018","unstructured":"Mano CM, Guaratini T, Cardozo KH, Colepicolo P, Bechara EJ, Barros MP (2018) Astaxanthin restrains nitrative-oxidative peroxidation in mitochondrial-mimetic liposomes: a pre-apoptosis model. Mar Drugs 16(4):126","journal-title":"Mar Drugs"},{"key":"1766_CR101","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1016\/j.actbio.2017.02.019","volume":"53","author":"S Mart\u00edn-Salda\u00f1a","year":"2017","unstructured":"Mart\u00edn-Salda\u00f1a S, Palao-Suay R, Aguilar MR, Ram\u00edrez-Camacho R, San Rom\u00e1n J (2017) Polymeric nanoparticles loaded with dexamethasone or \u03b1-tocopheryl succinate to prevent cisplatin-induced ototoxicity. Acta Biomater 53:199\u2013210","journal-title":"Acta Biomater"},{"key":"1766_CR102","doi-asserted-by":"publisher","first-page":"S27","DOI":"10.1212\/01.wnl.0001051096.16547.16","volume":"103","author":"C Mattson","year":"2024","unstructured":"Mattson C, Olson N, Ruiz Y, Zhong Q (2024) Drug-induced hearing loss. Neurology 103:S27\u2013S27","journal-title":"Neurology"},{"issue":"3","key":"1766_CR103","doi-asserted-by":"publisher","first-page":"419","DOI":"10.1200\/JCO.2005.03.6392","volume":"24","author":"M McCulloch","year":"2006","unstructured":"McCulloch M, See C, Shu X-J, Broffman M, Kramer A, Fan W-Y, Gao J, Lieb W, Shieh K, Colford JM Jr (2006) Astragalus-based Chinese herbs and platinum-based chemotherapy for advanced non\u2013small-cell lung cancer: meta-analysis of randomized trials. J Clin Oncol 24(3):419\u2013430","journal-title":"J Clin Oncol"},{"issue":"1","key":"1766_CR104","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1002\/cncr.33848","volume":"128","author":"AJ Meijer","year":"2022","unstructured":"Meijer AJ, Li KH, Brooks B, Clemens E, Ross CJ, Rassekh SR, Hoetink AE, van Grotel M, van den Heuvel-Eibrink MM, Carleton BC (2022) The cumulative incidence of cisplatin-induced hearing loss in young children is higher and develops at an early stage during therapy compared with older children based on 2052 audiological assessments. Cancer 128(1):169\u2013179","journal-title":"Cancer"},{"key":"1766_CR105","doi-asserted-by":"publisher","first-page":"1336714","DOI":"10.3389\/fonc.2024.1336714","volume":"14","author":"AJ Meijer","year":"2024","unstructured":"Meijer AJ, Diepstraten FA, van den Heuvel-Eibrink MM, Bleyer A (2024) Prevention of cisplatin-induced hearing loss in children: achievements and challenges for evidence-based implementation of sodium Thiosulfate. Front Oncol 14:1336714","journal-title":"Front Oncol"},{"issue":"25","key":"1766_CR106","doi-asserted-by":"publisher","first-page":"6597","DOI":"10.1016\/j.biomaterials.2010.04.062","volume":"31","author":"C Mohanty","year":"2010","unstructured":"Mohanty C, Sahoo SK (2010) The in vitro stability and in vivo pharmacokinetics of curcumin prepared as an aqueous nanoparticulate formulation. Biomaterials 31(25):6597\u20136611","journal-title":"Biomaterials"},{"issue":"3","key":"1766_CR107","doi-asserted-by":"publisher","first-page":"657","DOI":"10.1044\/2023_AJA-22-00157","volume":"32","author":"B Moore","year":"2023","unstructured":"Moore B, Sheets G, Doss J, Umrigar A, Norman M, Fang Z, Prasad P, Musso A, Clay S, Tsien F (2023) Is methotrexate ototoxic? Investigating the ototoxic late effects of pediatric cancer treatment. Am J Audiol 32(3):657\u2013664","journal-title":"Am J Audiol"},{"issue":"1","key":"1766_CR108","first-page":"1","volume":"23","author":"T Muderris","year":"2022","unstructured":"Muderris T, Yar Sa\u011flam AS, Unsal D, M\u00fclazimo\u011flu S, Sevil E, Kayhan H (2022) Efficiency of resveratrol in the prevention and treatment of age-related hearing loss. Exp Ther Med 23(1):1\u20137","journal-title":"Exp Ther Med"},{"issue":"7","key":"1766_CR109","doi-asserted-by":"publisher","first-page":"1189","DOI":"10.1007\/s00296-021-04868-6","volume":"41","author":"R Muller","year":"2021","unstructured":"Muller R (2021) Systemic toxicity of chloroquine and hydroxychloroquine: prevalence, mechanisms, risk factors, prognostic and screening possibilities. Rheumatol Int 41(7):1189\u20131202","journal-title":"Rheumatol Int"},{"issue":"13","key":"1766_CR110","doi-asserted-by":"publisher","first-page":"1001","DOI":"10.1089\/ars.2023.0006","volume":"38","author":"T M\u00fcnzel","year":"2023","unstructured":"M\u00fcnzel T, Daiber A (2023) Vascular redox signaling, endothelial nitric oxide synthase uncoupling, and endothelial dysfunction in the setting of transportation noise exposure or chronic treatment with organic nitrates. Antioxid Redox Signal 38(13):1001\u20131021","journal-title":"Antioxid Redox Signal"},{"key":"1766_CR111","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1016\/j.ijporl.2019.02.002","volume":"120","author":"T Nguyen","year":"2019","unstructured":"Nguyen T, Jeyakumar A (2019) Genetic susceptibility to aminoglycoside ototoxicity. Int J Pediatr Otorhinolaryngol 120:15\u201319","journal-title":"Int J Pediatr Otorhinolaryngol"},{"key":"1766_CR112","doi-asserted-by":"publisher","first-page":"242","DOI":"10.3389\/fncel.2017.00242","volume":"11","author":"V Noack","year":"2017","unstructured":"Noack V, Pak K, Jalota R, Kurabi A, Ryan AF (2017) An antioxidant screen identifies candidates for protection of cochlear hair cells from gentamicin toxicity. Front Cell Neurosci 11:242","journal-title":"Front Cell Neurosci"},{"key":"1766_CR113","doi-asserted-by":"publisher","first-page":"325","DOI":"10.3389\/fncel.2017.00325","volume":"11","author":"ME O\u2019Sullivan","year":"2017","unstructured":"O\u2019Sullivan ME, Perez A, Lin R, Sajjadi A, Ricci AJ, Cheng AG (2017) Towards the prevention of aminoglycoside-related hearing loss. Front Cell Neurosci 11:325","journal-title":"Front Cell Neurosci"},{"key":"1766_CR114","doi-asserted-by":"publisher","first-page":"150","DOI":"10.1016\/j.tiv.2019.01.008","volume":"56","author":"KRHM Oliveira","year":"2019","unstructured":"Oliveira KRHM, Dos Anjos LM, Ara\u00fajo APS, Luz WL, Kauffmann N, Braga DV, Passos ADCF, de Moraes SAS (2019) Ascorbic acid prevents chloroquine-induced toxicity in inner glial cells. Toxicol in Vitro 56:150\u2013155","journal-title":"Toxicol in Vitro"},{"issue":"1","key":"1766_CR115","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1016\/j.bjorl.2017.10.009","volume":"85","author":"D \u00d6zdemir","year":"2019","unstructured":"\u00d6zdemir D, \u00d6zg\u00fcr A, Kalkan Y, Terzi S, T\u00fcmkaya L, Y\u0131lmaz A, \u00c7eliker M, Dursun E (2019) The protective effects of whortleberry extract against cisplatin-induced ototoxicity in rats. Braz J Otorhinolaryngol 85(1):55\u201362","journal-title":"Braz J Otorhinolaryngol"},{"issue":"3","key":"1766_CR116","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1017\/S0022215115003473","volume":"130","author":"H \u00d6zel","year":"2016","unstructured":"\u00d6zel H, \u00d6zdo\u011fan F, G\u00fcrgen S, Esen E, Gen\u00e7 S, Sel\u00e7uk A (2016) Comparison of the protective effects of intratympanic dexamethasone and methylprednisolone against cisplatin-induced ototoxicity. J Laryngol Otol 130(3):225\u2013234","journal-title":"J Laryngol Otol"},{"issue":"1","key":"1766_CR117","doi-asserted-by":"publisher","first-page":"1063","DOI":"10.1038\/s41598-020-57965-0","volume":"10","author":"F Paciello","year":"2020","unstructured":"Paciello F, Fetoni AR, Mezzogori D, Rolesi R, Di Pino A, Paludetti G, Grassi C, Troiani D (2020) The dual role of curcumin and ferulic acid in counteracting chemoresistance and cisplatin-induced ototoxicity. Sci Rep 10(1):1063","journal-title":"Sci Rep"},{"issue":"2","key":"1766_CR118","doi-asserted-by":"publisher","first-page":"130","DOI":"10.1016\/j.mehy.2015.04.015","volume":"85","author":"K Parham","year":"2015","unstructured":"Parham K (2015) Prestin as a biochemical marker for early detection of acquired sensorineural hearing loss. Med Hypotheses 85(2):130\u2013133","journal-title":"Med Hypotheses"},{"key":"1766_CR119","doi-asserted-by":"publisher","first-page":"1379743","DOI":"10.3389\/fnmol.2024.1379743","volume":"17","author":"M-P Pasdelou","year":"2024","unstructured":"Pasdelou M-P, Byelyayeva L, Malmstr\u00f6m S, Pucheu S, Peytavy M, Laullier H, Hodges DB Jr, Tzafriri AR, Naert G (2024) Ototoxicity: a high risk to auditory function that needs to be monitored in drug development. Front Mol Neurosci 17:1379743","journal-title":"Front Mol Neurosci"},{"key":"1766_CR120","doi-asserted-by":"publisher","first-page":"130","DOI":"10.1016\/j.bjorl.2021.02.008","volume":"88","author":"FSA Patatt","year":"2022","unstructured":"Patatt FSA, Gon\u00e7alves LF, Paiva KMD, Haas P (2022) Ototoxic effects of antineoplastic drugs: a systematic review. Braz J Otorhinolaryngol 88:130\u2013140","journal-title":"Braz J Otorhinolaryngol"},{"key":"1766_CR121","doi-asserted-by":"publisher","DOI":"10.21203\/rs.3.rs-2240638\/v1","author":"P Pavlidis","year":"2022","unstructured":"Pavlidis P, Papadopoulou K, Tseriotis VS, Karachrysafi S, Sardeli C, Malliou F, Kavvadas D, Papamitsou T, Sioga A, Anastasiadou P (2022) \u039d-Methyl-D-aspartate antagonists and their role in limiting ototoxic phenomena. Res Square. https:\/\/doi.org\/10.21203\/rs.3.rs-2240638\/v1","journal-title":"Res Square"},{"key":"1766_CR122","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s12070-024-04521-1","volume":"76","author":"P Pavlidis","year":"2024","unstructured":"Pavlidis P, Tseriotis VS, Papadopoulou K, Karachrysafi S, Sardeli C, Gouveris H, Malliou F, Kavvadas D, Papamitsou T, Sioga A (2024) Role of memantine in limiting cochleotoxicity in rats. Indian J Otolaryngol Head Neck Surg 76:1\u201310","journal-title":"Indian J Otolaryngol Head Neck Surg"},{"issue":"4","key":"1766_CR123","doi-asserted-by":"publisher","first-page":"947","DOI":"10.3390\/nu12040947","volume":"12","author":"TNM Pham","year":"2020","unstructured":"Pham TNM, Jeong SY, Kim DH, Park YH, Lee JS, Lee KW, Moon IS, Choung SY, Kim SH, Kang TH (2020) Protective mechanisms of avocado oil extract against ototoxicity. Nutrients 12(4):947","journal-title":"Nutrients"},{"key":"1766_CR124","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1016\/B978-0-444-62630-1.00001-9","volume":"129","author":"JO Pickles","year":"2015","unstructured":"Pickles JO (2015) Auditory pathways: anatomy and physiology. Handb Clin Neurol 129:3\u201325","journal-title":"Handb Clin Neurol"},{"issue":"1","key":"1766_CR125","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1159\/000526403","volume":"28","author":"B Polski","year":"2023","unstructured":"Polski B, Sosnowska-Sienkiewicz P, Szyd\u0142owski J, Januszkiewicz-Lewandowska D (2023) Applications of the grading scales for the detection of ototoxicity in children after treatment of neuroblastoma and extracranial germinal tumor. Audiol Neurotol 28(1):32\u201342","journal-title":"Audiol Neurotol"},{"key":"1766_CR126","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2021.695268","volume":"15","author":"P Prayuenyong","year":"2021","unstructured":"Prayuenyong P, Baguley DM, Kros CJ, Steyger PS (2021) Preferential cochleotoxicity of cisplatin. Front Neurosci 15:695268","journal-title":"Front Neurosci"},{"issue":"1","key":"1766_CR127","doi-asserted-by":"publisher","first-page":"28747","DOI":"10.1038\/s41598-024-79150-3","volume":"14","author":"L Qiu","year":"2024","unstructured":"Qiu L, Li H, Li B, Ek J, Zhang X, Chen Y, Shao Z, Zhang J, Zhang J, Lin H (2024) Sevoflurane exposure in early life: mitochondrial dysfunction and neurotoxicity in immature rat brains without long-term memory loss. Sci Rep 14(1):28747","journal-title":"Sci Rep"},{"issue":"1","key":"1766_CR128","doi-asserted-by":"publisher","first-page":"e25","DOI":"10.1097\/MPH.0000000000001637","volume":"42","author":"D Rabi\u00e7o-Costa","year":"2020","unstructured":"Rabi\u00e7o-Costa D, Gil-da-Costa MJ, Barbosa JP, Bom-Sucesso M, Spratley J (2020) Platinum-drugs ototoxicity in pediatric patients with brain tumors: a 10-year review. J Pediatr Hematol Oncol 42(1):e25\u2013e31","journal-title":"J Pediatr Hematol Oncol"},{"issue":"12","key":"1766_CR129","doi-asserted-by":"publisher","first-page":"1919","DOI":"10.3390\/antiox10121919","volume":"10","author":"V Ramkumar","year":"2021","unstructured":"Ramkumar V, Mukherjea D, Dhukhwa A, Rybak LP (2021) Oxidative stress and inflammation caused by cisplatin ototoxicity. Antioxidants 10(12):1919","journal-title":"Antioxidants"},{"issue":"2","key":"1766_CR130","doi-asserted-by":"publisher","first-page":"283","DOI":"10.1016\/j.therap.2023.10.011","volume":"79","author":"P Reynard","year":"2024","unstructured":"Reynard P, Thai-Van H (2024) Drug-induced hearing loss: listening to the latest advances. Therapies 79(2):283\u2013295","journal-title":"Therapies"},{"key":"1766_CR131","doi-asserted-by":"publisher","first-page":"218","DOI":"10.1016\/j.phrs.2016.12.037","volume":"117","author":"R Rezaee","year":"2017","unstructured":"Rezaee R, Momtazi AA, Monemi A, Sahebkar A (2017) Curcumin: a potentially powerful tool to reverse cisplatin-induced toxicity. Pharmacol Res 117:218\u2013227","journal-title":"Pharmacol Res"},{"issue":"10","key":"1766_CR132","doi-asserted-by":"publisher","first-page":"1353","DOI":"10.3390\/ph16101353","volume":"16","author":"S Rivetti","year":"2023","unstructured":"Rivetti S, Romano A, Mastrangelo S, Attin\u00e0 G, Maurizi P, Ruggiero A (2023) Aminoglycosides-related ototoxicity: mechanisms, risk factors, and prevention in pediatric patients. Pharmaceuticals 16(10):1353","journal-title":"Pharmaceuticals"},{"issue":"12","key":"1766_CR133","doi-asserted-by":"publisher","first-page":"1265","DOI":"10.1002\/phar.2478","volume":"40","author":"HG Rizk","year":"2020","unstructured":"Rizk HG, Lee JA, Liu YF, Endriukaitis L, Isaac JL, Bullington WM (2020) Drug-induced ototoxicity: a comprehensive review and reference guide. Pharmacotherapy 40(12):1265\u20131275","journal-title":"Pharmacotherapy"},{"key":"1766_CR134","doi-asserted-by":"publisher","first-page":"1303","DOI":"10.1016\/j.biopha.2017.07.069","volume":"93","author":"I Rodriguez","year":"2017","unstructured":"Rodriguez I, Hong BN, Nam YH, Kim EY, Park GH, Ji MG, Kang TH (2017) Bioconversion of Scutellaria baicalensis extract can increase recovery of auditory function in a mouse model of noise-induced hearing loss. Biomed Pharmacother 93:1303\u20131309","journal-title":"Biomed Pharmacother"},{"issue":"16","key":"1766_CR135","doi-asserted-by":"publisher","first-page":"2716","DOI":"10.3390\/nu16162716","volume":"16","author":"I Rodriguez","year":"2024","unstructured":"Rodriguez I, Nam YH, Shin SW, Seo GJ, Kim NW, Nuankaew W, Kim DH, Park YH, Lee HY, Peng XH (2024) Effects of castanopsis echinocarpa on sensorineural hearing loss via neuronal gene regulation. Nutrients 16(16):2716","journal-title":"Nutrients"},{"issue":"5","key":"1766_CR136","doi-asserted-by":"publisher","first-page":"1266","DOI":"10.3390\/cancers12051266","volume":"12","author":"A Romano","year":"2020","unstructured":"Romano A, Capozza MA, Mastrangelo S, Maurizi P, Triarico S, Rolesi R, Attin\u00e0 G, Fetoni AR, Ruggiero A (2020) Assessment and management of platinum-related ototoxicity in children treated for cancer. Cancers 12(5):1266","journal-title":"Cancers"},{"key":"1766_CR137","first-page":"197","volume-title":"Seminars in hearing","author":"LP Rybak","year":"2019","unstructured":"Rybak LP, Mukherjea D, Ramkumar V (2019) Mechanisms of cisplatin-induced ototoxicity and prevention. Seminars in hearing, vol 40. Thieme Medical Publishers, New York, pp 197\u2013204"},{"issue":"7","key":"1766_CR138","doi-asserted-by":"publisher","first-page":"1131","DOI":"10.1097\/MAO.0000000000000403","volume":"35","author":"P Salehi","year":"2014","unstructured":"Salehi P, Akinpelu OV, Waissbluth S, Peleva E, Meehan B, Rak J, Daniel SJ (2014) Attenuation of cisplatin ototoxicity by otoprotective effects of nanoencapsulated curcumin and dexamethasone in a guinea pig model. Otol Neurotol 35(7):1131\u20131139","journal-title":"Otol Neurotol"},{"key":"1766_CR139","first-page":"627","volume-title":"Berry fruits: compositional elements, biochemical activities, and the impact of their intake on human health, performance, and disease","author":"NP Seeram","year":"2008","unstructured":"Seeram NP (2008) Berry fruits: compositional elements, biochemical activities, and the impact of their intake on human health, performance, and disease, vol 56. ACS Publications, Washington, pp 627\u2013629"},{"issue":"5","key":"1766_CR140","doi-asserted-by":"publisher","first-page":"827","DOI":"10.1177\/0194599813475777","volume":"148","author":"MD Seidman","year":"2013","unstructured":"Seidman MD, Tang W, Bai VU, Ahmad N, Jiang H, Media J, Patel N, Rubin CJ, Standring RT (2013) Resveratrol decreases noise-induced cyclooxygenase-2 expression in the rat cochlea. Otolaryngol Head Neck Surg 148(5):827\u2013833","journal-title":"Otolaryngol Head Neck Surg"},{"issue":"1","key":"1766_CR141","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1097\/MAO.0000000000002809","volume":"42","author":"MG Semedo","year":"2021","unstructured":"Semedo MG, Dias-Silva N, Migu\u00e9is J, Pita JR (2021) Quinine in otology and neurotology: ototoxicity and historic role in therapy. Otol Neurotol 42(1):145\u2013152","journal-title":"Otol Neurotol"},{"key":"1766_CR142","volume-title":"Auditory system-function and disorders","author":"A Sheikh","year":"2022","unstructured":"Sheikh A, Shabbir K, Imtiaz A (2022) Structure and physiology of human ear involved in hearing. In: Naz S (ed) Auditory system-function and disorders. IntechOpen, London"},{"key":"1766_CR143","doi-asserted-by":"publisher","first-page":"3548706","DOI":"10.1155\/2021\/3548706","volume":"1","author":"W Shi","year":"2021","unstructured":"Shi W, Hou X, Bao X, Hou W, Jiang X, Ma L, Jiang X, Dong L (2021) Mechanism and protection of radiotherapy induced sensorineural hearing loss for head and neck cancer. Biomed Res Int 1:3548706","journal-title":"Biomed Res Int"},{"key":"1766_CR144","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2024.e37223","author":"M Shi","year":"2024","unstructured":"Shi M, Wang Y, Yang H, Lai C, Yu J, Sun Y (2024) High doses of radiation cause cochlear immunological stress and sensorineural hearing loss. Heliyon. https:\/\/doi.org\/10.1016\/j.heliyon.2024.e37223","journal-title":"Heliyon"},{"issue":"2","key":"1766_CR145","doi-asserted-by":"publisher","first-page":"9","DOI":"10.17430\/JHS.2020.10.2.1","volume":"10","author":"MB Skarzynska","year":"2020","unstructured":"Skarzynska MB, Kr\u00f3l B, Czajka L (2020) Ototoxicity as a side-effect of drugs: literature review. J Hear Sci 10(2):9\u201319","journal-title":"J Hear Sci"},{"key":"1766_CR146","doi-asserted-by":"publisher","DOI":"10.1016\/j.heares.2020.108002","volume":"402","author":"S Someya","year":"2021","unstructured":"Someya S, Kim M-J (2021) Cochlear detoxification: Role of alpha class glutathione transferases in protection against oxidative lipid damage, ototoxicity, and cochlear aging. Hear Res 402:108002","journal-title":"Hear Res"},{"key":"1766_CR147","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1016\/j.ijporl.2016.08.012","volume":"89","author":"H Soyal\u0131\u00e7","year":"2016","unstructured":"Soyal\u0131\u00e7 H, Gevrek F, Ko\u00e7 S, Avcu M, Metin M, Alada\u011f \u0130 (2016) Intraperitoneal curcumin and vitamin E combination for the treatment of cisplatin-induced ototoxicity in rats. Int J Pediatr Otorhinolaryngol 89:173\u2013178","journal-title":"Int J Pediatr Otorhinolaryngol"},{"issue":"3S","key":"1766_CR148","doi-asserted-by":"publisher","first-page":"887","DOI":"10.1044\/2021_AJA-21-00006","volume":"30","author":"PS Steyger","year":"2021","unstructured":"Steyger PS (2021a) Mechanisms of aminoglycoside-and cisplatin-induced ototoxicity. Am J Audiol 30(3S):887\u2013900","journal-title":"Am J Audiol"},{"issue":"6","key":"1766_CR149","doi-asserted-by":"publisher","first-page":"1101","DOI":"10.1016\/j.otc.2021.08.007","volume":"54","author":"PS Steyger","year":"2021","unstructured":"Steyger PS (2021b) Mechanisms of ototoxicity and otoprotection. Otolaryngol Clin North Am 54(6):1101\u20131115","journal-title":"Otolaryngol Clin North Am"},{"key":"1766_CR150","doi-asserted-by":"publisher","DOI":"10.1016\/j.heares.2023.108783","volume":"434","author":"WJ Tan","year":"2023","unstructured":"Tan WJ, Song L (2023) Role of mitochondrial dysfunction and oxidative stress in sensorineural hearing loss. Hear Res 434:108783","journal-title":"Hear Res"},{"issue":"22","key":"1766_CR151","doi-asserted-by":"publisher","first-page":"16545","DOI":"10.3390\/ijms242216545","volume":"24","author":"WJ Tan","year":"2023","unstructured":"Tan WJ, Vlajkovic SM (2023) Molecular characteristics of cisplatin-induced ototoxicity and therapeutic interventions. Int J Mol Sci 24(22):16545","journal-title":"Int J Mol Sci"},{"key":"1766_CR152","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1016\/j.ejpb.2021.03.008","volume":"163","author":"Q Tang","year":"2021","unstructured":"Tang Q, Wang X, Jin H, Mi Y, Liu L, Dong M, Chen Y, Zou Z (2021) Cisplatin-induced ototoxicity: updates on molecular mechanisms and otoprotective strategies. Eur J Pharm Biopharm 163:60\u201371","journal-title":"Eur J Pharm Biopharm"},{"issue":"8","key":"1766_CR153","doi-asserted-by":"publisher","first-page":"4146","DOI":"10.3390\/ijms25084146","volume":"25","author":"M Teraoka","year":"2024","unstructured":"Teraoka M, Hato N, Inufusa H, You F (2024) Role of oxidative stress in sensorineural hearing loss. Int J Mol Sci 25(8):4146","journal-title":"Int J Mol Sci"},{"key":"1766_CR154","doi-asserted-by":"publisher","first-page":"369","DOI":"10.1016\/j.fct.2013.07.069","volume":"60","author":"CJ Tian","year":"2013","unstructured":"Tian CJ, Kim SW, Kim YJ, Lim HJ, Park R, So H-S, Choung Y-H (2013) Red ginseng protects against gentamicin-induced balance dysfunction and hearing loss in rats through antiapoptotic functions of ginsenoside Rb1. Food Chem Toxicol 60:369\u2013376","journal-title":"Food Chem Toxicol"},{"issue":"17","key":"1766_CR155","doi-asserted-by":"publisher","first-page":"1727","DOI":"10.1089\/ars.2017.7342","volume":"29","author":"C Tonelli","year":"2018","unstructured":"Tonelli C, Chio IIC, Tuveson DA (2018) Transcriptional regulation by Nrf2. Antioxid Redox Signal 29(17):1727\u20131745","journal-title":"Antioxid Redox Signal"},{"issue":"1","key":"1766_CR156","doi-asserted-by":"publisher","first-page":"3455","DOI":"10.1038\/s41598-019-40138-z","volume":"9","author":"E Tserga","year":"2019","unstructured":"Tserga E, Nandwani T, Edvall NK, Bulla J, Patel P, Canlon B, Cederroth CR, Baguley DM (2019) The genetic vulnerability to cisplatin ototoxicity: a systematic review. Sci Rep 9(1):3455","journal-title":"Sci Rep"},{"issue":"1","key":"1766_CR157","doi-asserted-by":"publisher","first-page":"219","DOI":"10.3390\/ijms25010219","volume":"25","author":"J-H Um","year":"2023","unstructured":"Um J-H, Lee K-M, Kim Y-Y, Lee D-Y, Kim E, Kim D-H, Yun J (2023) Berberine induces mitophagy through adenosine monophosphate-activated protein kinase and ameliorates mitochondrial dysfunction in pink1 knockout mouse embryonic fibroblasts. Int J Mol Sci 25(1):219","journal-title":"Int J Mol Sci"},{"issue":"1","key":"1766_CR158","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1038\/s41420-019-0195-1","volume":"5","author":"A Umugire","year":"2019","unstructured":"Umugire A, Lee S, Kim D, Choi M, Kim H-S, Cho H-H (2019) Avenanthramide-C prevents noise-and drug-induced hearing loss while protecting auditory hair cells from oxidative stress. Cell Death Discovery 5(1):115","journal-title":"Cell Death Discovery"},{"issue":"3","key":"1766_CR159","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0266108","volume":"17","author":"A Umugire","year":"2022","unstructured":"Umugire A, Choi Y, Lee S, Cho H-H (2022) Efficiency of antioxidant Avenanthramide-C on high-dose methotrexate-induced ototoxicity in mice. PLoS ONE 17(3):e0266108","journal-title":"PLoS ONE"},{"issue":"3","key":"1766_CR160","doi-asserted-by":"publisher","first-page":"2947","DOI":"10.3390\/ijms24032947","volume":"24","author":"A Umugire","year":"2023","unstructured":"Umugire A, Nam YS, Nam YE, Choi YM, Choi SM, Lee S, Cho JH, Cho H-H (2023) Protective effect of avenanthramide-C on auditory hair cells against oxidative stress, inflammatory cytokines, and DNA damage in cisplatin-induced ototoxicity. Int J Mol Sci 24(3):2947","journal-title":"Int J Mol Sci"},{"issue":"4","key":"1766_CR161","doi-asserted-by":"publisher","first-page":"2477","DOI":"10.1152\/physrev.00053.2017","volume":"98","author":"J Wang","year":"2018","unstructured":"Wang J, Puel J-L (2018) Toward cochlear therapies. Physiol Rev 98(4):2477\u20132522","journal-title":"Physiol Rev"},{"key":"1766_CR162","first-page":"177","volume-title":"Seminars in hearing","author":"KL Watts","year":"2019","unstructured":"Watts KL (2019) Ototoxicity: visualized in concept maps. Seminars in hearing, vol 40. Thieme Medical Publishers, New York, pp 177\u2013187"},{"issue":"5","key":"1766_CR163","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3892\/ijmm.2022.5127","volume":"49","author":"Y-H Wen","year":"2022","unstructured":"Wen Y-H, Lin H-Y, Lin J-N, Tseng G-F, Hwang C-F, Lin C-C, Hsu C-J, Wu H-P (2022) 2, 3, 4\u2019, 5-Tetrahydroxystilbene-2-O-\u03b2-D-glucoside ameliorates gentamicin-induced ototoxicity by modulating autophagy via Sesn2\/AMPK\/mTOR signaling. Int J Mol Med 49(5):1\u201311","journal-title":"Int J Mol Med"},{"issue":"2","key":"1766_CR164","doi-asserted-by":"publisher","first-page":"424","DOI":"10.1124\/jpet.104.075119","volume":"312","author":"YJ Wu","year":"2005","unstructured":"Wu YJ, Muldoon LL, Neuwelt EA (2005) The chemoprotective agent N-acetylcysteine blocks cisplatin-induced apoptosis through caspase signaling pathway. J Pharmacol Exp Ther 312(2):424\u2013431","journal-title":"J Pharmacol Exp Ther"},{"key":"1766_CR165","doi-asserted-by":"publisher","first-page":"429","DOI":"10.1016\/j.neuropharm.2017.01.001","volume":"116","author":"X Wu","year":"2017","unstructured":"Wu X, Li X, Song Y, Li H, Bai X, Liu W, Han Y, Xu L, Li J, Zhang D (2017) Allicin protects auditory hair cells and spiral ganglion neurons from cisplatin-Induced apoptosis. Neuropharmacology 116:429\u2013440","journal-title":"Neuropharmacology"},{"key":"1766_CR166","first-page":"4909237","volume":"1","author":"P Wu","year":"2021","unstructured":"Wu P, Wu X, Zhang C, Chen X, Huang Y, Li H (2021) (2021) Hair cell protection from ototoxic drugs. Neural Plast 1:4909237","journal-title":"Neural Plast"},{"key":"1766_CR167","doi-asserted-by":"publisher","first-page":"66","DOI":"10.1016\/j.molimm.2022.06.006","volume":"149","author":"L Wu","year":"2022","unstructured":"Wu L, Chen M, Li M, Wang Y, Li Y, Zheng L, Ke Z, Liu K, Qiao Y (2022) Oridonin alleviates kanamycin-related hearing loss by inhibiting NLRP3\/caspase-1\/gasdermin D-induced inflammasome activation and hair cell pyroptosis. Mol Immunol 149:66\u201376","journal-title":"Mol Immunol"},{"issue":"3","key":"1766_CR168","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1159\/000326240","volume":"73","author":"M Xiong","year":"2011","unstructured":"Xiong M, He Q, Wang J, Lai H (2011) Astragalosides reduce cisplatin ototoxicity in guinea pigs. ORL 73(3):131\u2013136","journal-title":"ORL"},{"key":"1766_CR169","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s12035-024-04179-4","volume":"61","author":"H Yang","year":"2024","unstructured":"Yang H, Zong T, Liu J, Wang D, Gong K, Yin H, Zhang W, Xu T, Yang R (2024) Rutin attenuates gentamycin-induced hair cell injury in the zebrafish lateral line via suppressing STAT1. Mol Neurobiol 61:1\u201314","journal-title":"Mol Neurobiol"},{"issue":"6","key":"1766_CR170","doi-asserted-by":"publisher","first-page":"3115","DOI":"10.1021\/acs.jmedchem.0c01916","volume":"64","author":"R Ye","year":"2021","unstructured":"Ye R, Sun L, Peng J, Wu A, Chen X, Wen L, Bai C, Chen G (2021) Design, synthesis, and biological evaluation of dexamethasone\u2013salvianolic acid B conjugates and nanodrug delivery against cisplatin-induced hearing loss. J Med Chem 64(6):3115\u20133130","journal-title":"J Med Chem"},{"issue":"3","key":"1766_CR171","doi-asserted-by":"publisher","first-page":"E87","DOI":"10.1002\/lary.24360","volume":"124","author":"J Yoo","year":"2014","unstructured":"Yoo J, Hamilton SJ, Angel D, Fung K, Franklin J, Parnes LS, Lewis D, Venkatesan V, Winquist E (2014) Cisplatin otoprotection using transtympanic L-N-acetylcysteine: a pilot randomized study in head and neck cancer patients. Laryngoscope 124(3):E87\u2013E94","journal-title":"Laryngoscope"},{"issue":"8","key":"1766_CR172","doi-asserted-by":"publisher","first-page":"5098","DOI":"10.1111\/jcmm.14379","volume":"23","author":"X Yu","year":"2019","unstructured":"Yu X, Man R, Li Y, Yang Q, Li H, Yang H, Bai X, Yin H, Li J, Wang H (2019) Paeoniflorin protects spiral ganglion neurons from cisplatin-induced ototoxicity: possible relation to PINK1\/BAD pathway. J Cell Mol Med 23(8):5098\u20135107","journal-title":"J Cell Mol Med"},{"key":"1766_CR173","doi-asserted-by":"publisher","first-page":"999","DOI":"10.3389\/fphar.2020.00999","volume":"11","author":"D Yu","year":"2020","unstructured":"Yu D, Gu J, Chen Y, Kang W, Wang X, Wu H (2020) Current strategies to combat cisplatin-induced ototoxicity. Front Pharmacol 11:999","journal-title":"Front Pharmacol"},{"issue":"8","key":"1766_CR174","doi-asserted-by":"publisher","first-page":"7596","DOI":"10.3390\/ijms24087596","volume":"24","author":"M Zadro\u017cniak","year":"2023","unstructured":"Zadro\u017cniak M, Szyma\u0144ski M, \u0141uszczki JJ (2023) N-Acetyl-L-cysteine affects ototoxicity evoked by amikacin and furosemide either alone or in combination in a mouse model of hearing threshold decrease. Int J Mol Sci 24(8):7596","journal-title":"Int J Mol Sci"},{"key":"1766_CR175","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.toxlet.2020.04.005","volume":"331","author":"W Zhang","year":"2020","unstructured":"Zhang W, Xiong H, Pang J, Su Z, Lai L, Lin H, Jian B, He W, Yang H, Zheng Y (2020) Nrf2 activation protects auditory hair cells from cisplatin-induced ototoxicity independent on mitochondrial ROS production. Toxicol Lett 331:1\u201310","journal-title":"Toxicol Lett"},{"key":"1766_CR176","first-page":"5520794","volume":"1","author":"L Zhang","year":"2021","unstructured":"Zhang L, Du Z, Gong S (2021) (2021) Mitochondrial dysfunction and sirtuins: important targets in hearing loss. Neural Plast 1:5520794","journal-title":"Neural Plast"},{"key":"1766_CR177","doi-asserted-by":"publisher","DOI":"10.3389\/fbioe.2022.876237","volume":"10","author":"Q Zhang","year":"2022","unstructured":"Zhang Q, Wu Y, Yu Y, Niu Y, Fang Q, Chen X, Qi J, Zhang C, Wu G, Su K (2022) Tetrandrine prevents neomycin-induced ototoxicity by promoting steroid biosynthesis. Front Bioeng Biotechnol 10:876237","journal-title":"Front Bioeng Biotechnol"},{"key":"1766_CR178","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2023.137518","volume":"817","author":"J Zhang","year":"2023","unstructured":"Zhang J, Song J, Li H, Li Z, Chen M, Ma S, Shen R, Lou X (2023) Berberine protects against neomycin-induced ototoxicity by reducing ROS generation and activating the PI3K\/AKT pathway. Neurosci Lett 817:137518","journal-title":"Neurosci Lett"},{"key":"1766_CR179","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijporl.2021.110920","volume":"150","author":"Y Zong","year":"2021","unstructured":"Zong Y, Chen F, Li S, Zhang H (2021) (\u2212)-Epigallocatechin-3-gallate (EGCG) prevents aminoglycosides-induced ototoxicity via anti-oxidative and anti-apoptotic pathways. Int J Pediatr Otorhinolaryngol 150:110920","journal-title":"Int J Pediatr Otorhinolaryngol"}],"container-title":["Inflammopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10787-025-01766-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10787-025-01766-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10787-025-01766-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,8]],"date-time":"2025-05-08T19:03:03Z","timestamp":1746730983000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10787-025-01766-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5,8]]},"references-count":179,"alternative-id":["1766"],"URL":"https:\/\/doi.org\/10.1007\/s10787-025-01766-2","relation":{},"ISSN":["0925-4692","1568-5608"],"issn-type":[{"value":"0925-4692","type":"print"},{"value":"1568-5608","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,5,8]]},"assertion":[{"value":"11 April 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 April 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 May 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}}]}}