{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T22:12:17Z","timestamp":1792188737937,"version":"4.4.0"},"reference-count":71,"publisher":"Springer Science and Business Media LLC","issue":"8","license":[{"start":{"date-parts":[[2025,7,5]],"date-time":"2025-07-05T00:00:00Z","timestamp":1751673600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,7,5]],"date-time":"2025-07-05T00:00:00Z","timestamp":1751673600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100006769","name":"Russian Science Foundation","doi-asserted-by":"publisher","award":["25-25-00048"],"award-info":[{"award-number":["25-25-00048"]}],"id":[{"id":"10.13039\/501100006769","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Inflammopharmacol"],"published-print":{"date-parts":[[2025,8]]},"DOI":"10.1007\/s10787-025-01834-7","type":"journal-article","created":{"date-parts":[[2025,7,5]],"date-time":"2025-07-05T14:52:21Z","timestamp":1751727141000},"page":"4787-4805","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Synaptamide regulates astroglial functional activity after cerebral cortex injury"],"prefix":"10.1007","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8184-7577","authenticated-orcid":false,"given":"Igor","family":"Manzhulo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anastasia","family":"Egoraeva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Darya","family":"Ivashkevich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olga","family":"Manzhulo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arina","family":"Ponomarenko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,7,5]]},"reference":[{"issue":"8","key":"1834_CR1","doi-asserted-by":"publisher","first-page":"911","DOI":"10.1139\/o59-099","volume":"37","author":"EG Bligh","year":"1959","unstructured":"Bligh EG, Dyer WJ (1959) A rapid method of total lipid extraction and purification. Can J Biochem Physiol 37(8):911\u2013917","journal-title":"Can J Biochem Physiol"},{"key":"1834_CR2","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1016\/0306-4522(94)90069-8","volume":"61","author":"E Castr\u00e9n","year":"1994","unstructured":"Castr\u00e9n E, Ohga Y, Berzaghi MP, Tzimagiorgis G, Thoenen H, Lindholm D (1994) Bcl-2 messenger RNA is localized in neurons of the developing and adult rat brain. Neuroscience 61:165\u2013177","journal-title":"Neuroscience"},{"key":"1834_CR3","doi-asserted-by":"publisher","first-page":"9172","DOI":"10.1523\/JNEUROSCI.17-23-09172.1997","volume":"17","author":"RS Clark","year":"1997","unstructured":"Clark RS, Chen J, Watkins SC, Kochanek PM, Chen M, Stetler RA, Loeffert JE, Graham SH (1997) Apoptosis-suppressor gene bcl-2 expression after traumatic brain injury in rats. J Neurosci 17:9172\u20139182","journal-title":"J Neurosci"},{"issue":"8","key":"1834_CR4","doi-asserted-by":"publisher","first-page":"813","DOI":"10.1096\/fasebj.13.8.813","volume":"13","author":"RS Clark","year":"1999","unstructured":"Clark RS, Kochanek PM, Chen M, Watkins SC, Marion DW, Chen J, Hamilton RL, Loeffert JE, Graham SH (1999) Increases in Bcl-2 and cleavage of caspase-1 and caspase-3 in human brain after head injury. FASEB J 13(8):813\u2013821","journal-title":"FASEB J"},{"key":"1834_CR5","doi-asserted-by":"publisher","first-page":"528","DOI":"10.1002\/glia.23736","volume":"68","author":"T Cl\u00e9ment","year":"2020","unstructured":"Cl\u00e9ment T, Lee JB, Ichkova A, Rodriguez-Grande B, Fournier ML, Aussudre J, Ogier M, Haddad E, Canini F, Koehl M, Abrous DN, Obenaus A, Badaut J (2020) Juvenile mild traumatic brain injury elicits distinct spatiotemporal astrocyte responses. Glia 68:528\u2013542","journal-title":"Glia"},{"key":"1834_CR6","doi-asserted-by":"publisher","first-page":"907","DOI":"10.1038\/cdd.2010.169","volume":"18","author":"O Cordero-Llana","year":"2011","unstructured":"Cordero-Llana O, Scott SA, Maslen SL, Anderson JM, Boyle J, Chowhdury RR, Tyers P, Barker RA, Kelly CM, Rosser AE, Stephens E, Chandran S, Caldwell MA (2011) Clusterin secreted by astrocytes enhances neuronal differentiation from human neural precursor cells. Cell Death Differ 18:907\u2013913","journal-title":"Cell Death Differ"},{"key":"1834_CR7","doi-asserted-by":"publisher","first-page":"1770","DOI":"10.1089\/neu.2011.2127","volume":"29","author":"E Czeiter","year":"2012","unstructured":"Czeiter E, Mondello S, Kovacs N, Sandor J, Gabrielli A, Schmid K, Tortella F, Wang KKW, Hayes RL, Barzo P, Ezer E, Doczi T, Buki A (2012) Brain injury biomarkers may improve the predictive power of the IMPACT outcome calculator. J Neurotrauma 29:1770\u20131778","journal-title":"J Neurotrauma"},{"key":"1834_CR8","doi-asserted-by":"publisher","first-page":"1869","DOI":"10.3390\/ijms19071869","volume":"19","author":"M D\u2019Angelo","year":"2018","unstructured":"D\u2019Angelo M, Antonosante A, Castelli V, Catanesi M, Moorthy N, Iannotta D, Cimini A, Benedetti E (2018) PPARs and energy metabolism adaptation during neurogenesis and neuronal maturation. Int J Mol Sci 19:1869","journal-title":"Int J Mol Sci"},{"key":"1834_CR9","doi-asserted-by":"publisher","first-page":"2729","DOI":"10.1111\/ejn.13737","volume":"46","author":"F Darlot","year":"2017","unstructured":"Darlot F, Vinit S, Matarazzo V, Kastner A (2017) Sustained cell body reactivity and loss of NeuN in a subset of axotomized bulbospinal neurons after a chronic high cervical spinal cord injury. Eur J Neurosci 46:2729\u20132745","journal-title":"Eur J Neurosci"},{"key":"1834_CR11","doi-asserted-by":"publisher","first-page":"300","DOI":"10.3390\/medicina56060300","volume":"56","author":"H Deng","year":"2020","unstructured":"Deng H, Yue JK, Zusman BE, Nwachuku EL, Abou-Al-Shaar H, Upadhyayula PS, Okonkwo DO, Puccio AM (2020) B-cell lymphoma 2 (Bcl-2) and regulation of apoptosis after traumatic brain injury: a clinical perspective. Medicina (Kaunas) 56:300","journal-title":"Medicina (Kaunas)"},{"key":"1834_CR12","first-page":"311","volume":"28","author":"S Ekmark-Lew\u00e9n","year":"2010","unstructured":"Ekmark-Lew\u00e9n S, Lew\u00e9n A, Israelsson C, Li GL, Farooque M, Olsson Y, Ebendal T, Hillered L (2010) Vimentin and GFAP responses in astrocytes after contusion trauma to the murine brain. Restor Neurol Neurosci 28:311\u2013321","journal-title":"Restor Neurol Neurosci"},{"key":"1834_CR13","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1016\/0006-8993(81)90067-6","volume":"211","author":"DM Feeney","year":"1981","unstructured":"Feeney DM, Boyeson MG, Linn RT, Murray HM, Dail WG (1981) Responses to cortical injury: I. Methodology and local effects of contusions in the rat. Brain Res 211:67\u201377","journal-title":"Brain Res"},{"key":"1834_CR14","doi-asserted-by":"publisher","first-page":"8854","DOI":"10.1523\/JNEUROSCI.23-26-08854.2003","volume":"2","author":"NG Forger","year":"2003","unstructured":"Forger NG, Prevette D, deLapeyri\u00e8re O, de Bovis B, Wang S, Bartlett P, Oppenheim RW (2003) Cardiotrophin-like cytokine\/cytokine-like factor 1 is an essential trophic factor for lumbar and facial motoneurons in vivo. J Neurosci 2:8854\u20138858","journal-title":"J Neurosci"},{"issue":"13","key":"1834_CR15","doi-asserted-by":"publisher","first-page":"4610","DOI":"10.1523\/JNEUROSCI.0374-12.2012","volume":"32","author":"JR Gomes","year":"2012","unstructured":"Gomes JR, Costa JT, Melo CV, Felizzi F, Monteiro P et al (2012) Excitotoxicity downregulates TrkB. FL signaling and upregulates the neuroprotective truncated TrkB receptors in cultured hippocampal and striatal neurons. J Neurosci 32(13):4610\u20134622","journal-title":"J Neurosci"},{"key":"1834_CR16","doi-asserted-by":"publisher","first-page":"831","DOI":"10.1089\/neu.2000.17.831","volume":"17","author":"SH Graham","year":"2000","unstructured":"Graham SH, Chen J, Clark RS (2000) Bcl-2 family gene products in cerebral ischemia and traumatic brain injury. J Neurotrauma 17:831\u2013841","journal-title":"J Neurotrauma"},{"key":"1834_CR17","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1186\/s13024-020-00391-7","volume":"15","author":"T Guo","year":"2020","unstructured":"Guo T, Zhang D, Zeng Y, Huang TY, Xu H, Zhao Y (2020) Molecular and cellular mechanisms underlying the pathogenesis of Alzheimer\u2019s disease. Mol Neurodegener 15:40","journal-title":"Mol Neurodegener"},{"key":"1834_CR18","doi-asserted-by":"publisher","first-page":"3278","DOI":"10.1177\/0271678X17724681","volume":"37","author":"J Halford","year":"2017","unstructured":"Halford J, Shen S, Itamura K, Levine J, Chong AC, Czerwieniec G, Glenn TC, Hovda DA, Vespa P, Bullock R, Dietrich WD, Mondello S, Loo JA, Wanner IB (2017) New astroglial injury-defined biomarkers for neurotrauma assessment. J Cereb Blood Flow Metab 37:3278\u20133299","journal-title":"J Cereb Blood Flow Metab"},{"key":"1834_CR19","doi-asserted-by":"publisher","first-page":"1274","DOI":"10.1091\/mbc.e10-08-0699","volume":"22","author":"BT Helfand","year":"2011","unstructured":"Helfand BT, Mendez MG, Murthy SNP, Shumaker DK, Grin B, Mahammad S, Aebi U, Wedig T, Wu YI, Hahn KM, Inagaki M, Herrmann H, Goldman RD (2011) Vimentin organization modulates the formation of lamellipodia. Mol Biol Cell 22:1274\u20131289","journal-title":"Mol Biol Cell"},{"key":"1834_CR20","doi-asserted-by":"publisher","first-page":"334","DOI":"10.1038\/348334a0","volume":"348","author":"D Hockenbery","year":"1990","unstructured":"Hockenbery D, Nu\u00f1ez G, Milliman C, Schreiber RD, Korsmeyer SJ (1990) Bcl-2 is an inner mitochondrial membrane protein that blocks programmed cell death. Nature 348:334\u2013336","journal-title":"Nature"},{"key":"1834_CR21","first-page":"311","volume":"16","author":"DN Ivashkevich","year":"2022","unstructured":"Ivashkevich DN, Manzhulo IV, Ponomarenko AI, Tyrtyshnaia AA, Dyuizen IV (2022) Analgesic activity of palmitoylethanolamide on neuropathic pain in rats. Exp Artic 16:311\u2013321","journal-title":"Exp Artic"},{"key":"1834_CR22","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1016\/j.expneurol.2012.01.013","volume":"246","author":"VE Johnson","year":"2013","unstructured":"Johnson VE, Stewart W, Smith DH (2013) Axonal pathology in traumatic brain injury. Exp Neurol 246:35\u201343","journal-title":"Exp Neurol"},{"key":"1834_CR23","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1016\/j.mam.2018.03.004","volume":"64","author":"HY Kim","year":"2018","unstructured":"Kim HY, Spector AA (2018) N-Docosahexaenoylethanolamine: a neurotrophic and neuroprotective metabolite of docosahexaenoic acid. Mol Aspects Med 64:34\u201344","journal-title":"Mol Aspects Med"},{"key":"1834_CR24","doi-asserted-by":"publisher","first-page":"31052","DOI":"10.1074\/jbc.M109.052969","volume":"284","author":"KK Kim","year":"2009","unstructured":"Kim KK, Adelstein RA, Kawamoto S (2009) Identification of neuronal nuclei (NeuN) as Fox-3, a new member of the Fox-1 gene family of splicing factors. J Biol Chem 284:31052\u201331061","journal-title":"J Biol Chem"},{"key":"1834_CR25","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1016\/0092-8674(91)90419-Y","volume":"65","author":"R Klein","year":"1991","unstructured":"Klein R, Jing SQ, Nanduri V, O\u2019Rourke E, Barbacid M (1991) The trk proto-oncogene encodes a receptor for nerve growth factor. Cell 65:189\u2013197","journal-title":"Cell"},{"key":"1834_CR26","doi-asserted-by":"publisher","first-page":"606","DOI":"10.1089\/neu.2015.4133","volume":"33","author":"PM Kochanek","year":"2016","unstructured":"Kochanek PM, Bramlett HM, Shear DA, Dixon CE, Mondello S, Dietrich WD, Hayes RL, Wang KKW, Poloyac SM, Empey PE, Povlishock JT, Andrea Mountney A, Browning M, Deng-Bryant Y, Yan HQ, Jackson TC, Catania M, Glushakova O, Richieri SP, Tortella FC (2016) Synthesis of findings, current investigations, and future directions: operation brain trauma therapy. J Neurotrauma 33:606\u2013614","journal-title":"J Neurotrauma"},{"key":"1834_CR27","doi-asserted-by":"publisher","first-page":"867","DOI":"10.1111\/j.1523-1755.2005.00151.x","volume":"67","author":"H Li","year":"2005","unstructured":"Li H, Ruan XZ, Powis SH, Fernando R, Mon WY, Wheeler DC, Moorhead JF, Varghese Z (2005) EPA and DHA reduce LPS-induced inflammation responses in HK-2 cells: evidence for a PPAR-gamma-dependent mechanism. Kidney Int 67:867\u2013874","journal-title":"Kidney Int"},{"key":"1834_CR28","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1016\/j.neuron.2014.11.018","volume":"85","author":"H Lian","year":"2015","unstructured":"Lian H, Yang L, Cole A, Sun L, Chiang ACA, Fowler SW, Shim DJ, Rodriguez-Rivera J, Taglialatela G, Jankowsky JL, Lu HC, Zheng H (2015) NF\u03baB-activated astroglial release of complement C3 compromises neuronal morphology and function associated with Alzheimer\u2019s disease. Neuron 85:101\u2013115","journal-title":"Neuron"},{"key":"1834_CR29","doi-asserted-by":"publisher","first-page":"957","DOI":"10.1016\/j.immuni.2017.06.006","volume":"46","author":"SA Liddelow","year":"2017","unstructured":"Liddelow SA, Barres BA (2017) Reactive astrocytes: production, function, and therapeutic potential. Immunity 46:957\u2013967","journal-title":"Immunity"},{"key":"1834_CR30","doi-asserted-by":"publisher","first-page":"662","DOI":"10.1111\/jnc.14067","volume":"142","author":"L Lin","year":"2017","unstructured":"Lin L, Metherel AH, Jones PJ, Bazinet RP (2017) Fatty acid amide hydrolase (FAAH) regulates hypercapnia\/ischemia-induced increases in n-acylethanolamines in mouse brain. J Neurochem 142:662\u2013671","journal-title":"J Neurochem"},{"key":"1834_CR31","doi-asserted-by":"publisher","first-page":"1053","DOI":"10.1038\/s41423-019-0278-1","volume":"17","author":"Y Lou","year":"2020","unstructured":"Lou Y, Han M, Liu H, Niu Y, Liang Y, Guo J, Zhang W, Wang H (2020) Essential roles of S100A10 in Toll-like receptor signaling and immunity to infection. Cell Mol Immunol 17:1053\u20131062","journal-title":"Cell Mol Immunol"},{"key":"1834_CR32","doi-asserted-by":"publisher","first-page":"1561","DOI":"10.3390\/brainsci11121561","volume":"11","author":"I Manzhulo","year":"2021","unstructured":"Manzhulo I, Manzhulo O, Tyrtyshnaia A, Ponomarenko A, Konovalova S, Ermolenko E, Milkina E, Starinets A (2021) Modulation of hippocampal astroglial activity by synaptamide in rats with neuropathic pain. Brain Sci 11:1561","journal-title":"Brain Sci"},{"key":"1834_CR33","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2024.110094","volume":"258","author":"I Manzhulo","year":"2024","unstructured":"Manzhulo I, Tyrtyshnaia A, Egoraeva A, Ivashkevich D, Girich A, Manzhulo O (2024) Anti-inflammatory and anti-apoptotic activity of synaptamide improves the morphological state of neurons in traumatic brain injury. Neuropharmacology 258:110094","journal-title":"Neuropharmacology"},{"key":"1834_CR34","doi-asserted-by":"publisher","first-page":"182","DOI":"10.1016\/j.expneurol.2003.10.001","volume":"185","author":"LT McPhail","year":"2004","unstructured":"McPhail LT, McBride CB, McGraw J, Steeves JD, Tetzlaff W (2004) Axotomy abolishes NeuN expression in facial but not rubrospinal neurons. Exp Neurol 185:182\u2013190","journal-title":"Exp Neurol"},{"key":"1834_CR35","doi-asserted-by":"publisher","first-page":"8999","DOI":"10.1073\/pnas.1533187100","volume":"100","author":"V Menet","year":"2003","unstructured":"Menet V, Prieto M, Privat A, Gimenezy-Ribotta M (2003) Axonal plasticity and functional recovery after spinal cord injury in mice deficient in both glial fibrillary acidic protein and Vimentin genes. PNAS 100:8999\u20139004","journal-title":"PNAS"},{"key":"1834_CR36","doi-asserted-by":"publisher","first-page":"1022","DOI":"10.1182\/blood-2010-05-284083","volume":"116","author":"LA Miles","year":"2010","unstructured":"Miles LA, Parmer RJ (2010) S100A10: a complex inflammatory role. Blood 116:1022\u20131024","journal-title":"Blood"},{"key":"1834_CR37","doi-asserted-by":"publisher","DOI":"10.1016\/j.plipres.2022.101194","volume":"89","author":"ED Mock","year":"2023","unstructured":"Mock ED, Gagestein B, Stelt M (2023) Anandamide and other N-acylethanolamines: a class of signaling lipids with therapeutic opportunities. Prog Lipid Res 89:101194","journal-title":"Prog Lipid Res"},{"key":"1834_CR38","doi-asserted-by":"publisher","first-page":"R156","DOI":"10.1186\/cc10286","volume":"15","author":"S Mondello","year":"2011","unstructured":"Mondello S, Papa L, Buki A, Bullock MR, Czeiter E, Tortella FC, Wang KK, Hayes RL (2011) Neuronal and glial markers are differently associated with computed tomography findings and outcome in patients with severe traumatic brain injury: a case control study. Crit Care 15:R156","journal-title":"Crit Care"},{"key":"1834_CR39","doi-asserted-by":"publisher","first-page":"1096","DOI":"10.1089\/neu.2011.2092","volume":"29","author":"S Mondello","year":"2012","unstructured":"Mondello S, Jeromin A, Buki A, Bullock R, Czeiter E, Kovacs N, Barzo P, Schmid K, Tortella F, Wang KW, Hayes RL (2012) Glial neuronal ratio: a novel index for differentiating injury type in patients with severe traumatic brain injury. J Neurotrauma 29:1096\u20131104","journal-title":"J Neurotrauma"},{"key":"1834_CR40","doi-asserted-by":"publisher","first-page":"595","DOI":"10.1089\/neu.2015.4132","volume":"33","author":"S Mondello","year":"2016","unstructured":"Mondello S, Shear DA, Bramlett HM, Dixon CE, Schmid KE, Dietrich WD, Wang KKW, Hayes RL, Glushakova O, Catania M, Richieri SP, Povlishock JP, Tortella FC, Kochanek PM (2016) Insight into pre-clinical models of traumatic brain injury using circulating brain damage biomarkers: operation brain trauma therapy. J Neurotrauma 33:595\u2013605","journal-title":"J Neurotrauma"},{"key":"1834_CR41","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1038\/ncb898","volume":"5","author":"N Mor-Vaknin","year":"2003","unstructured":"Mor-Vaknin N, Punturieri A, Sitwala K, Markovitz DM (2003) Vimentin is secreted by activated macrophages. Nat Cell Biol 5:59\u201363","journal-title":"Nat Cell Biol"},{"key":"1834_CR42","doi-asserted-by":"publisher","first-page":"5448","DOI":"10.1523\/JNEUROSCI.4247-15.2016","volume":"36","author":"A Nakamura","year":"2016","unstructured":"Nakamura A, Swahari V, Plestant C, Smith I, McCoy E, Smith S, Moy SS, Anton ES, Deshmukh M (2016) Bcl-xL Is essential for the survival and function of differentiated neurons in the cortex that control complex behaviors. J Neurosci 36:5448\u20135461","journal-title":"J Neurosci"},{"key":"1834_CR43","doi-asserted-by":"publisher","first-page":"528","DOI":"10.3389\/fncel.2019.00528","volume":"13","author":"SY Ng","year":"2019","unstructured":"Ng SY, Lee AYW (2019) Traumatic brain injuries: pathophysiology and potential therapeutic targets. Front Cell Neurosci 13:528","journal-title":"Front Cell Neurosci"},{"key":"1834_CR44","doi-asserted-by":"publisher","first-page":"574","DOI":"10.1038\/nn.3054","volume":"15","author":"D Ofengeim","year":"2012","unstructured":"Ofengeim D, Chen YB, Miyawaki T, Li H, Sacchetti S, Flannery RJ, Alavian KN, Pontarelli F, Roelofs BA, Hickman JA, Hardwick JM, Zukin RS, Jonas EA (2012) N-terminally cleaved Bcl-xL mediates ischemia-induced neuronal death. Nat Neurosci 15:574\u2013580","journal-title":"Nat Neurosci"},{"key":"1834_CR45","doi-asserted-by":"publisher","first-page":"371","DOI":"10.1016\/j.neuint.2003.07.006","volume":"45","author":"YB Ouyang","year":"2004","unstructured":"Ouyang YB, Giffard RG (2004) Changes in astrocyte mitochondrial function with stress: effects of Bcl-2 family proteins. Neurochem Int 45:371\u2013379","journal-title":"Neurochem Int"},{"key":"1834_CR46","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1089\/ars.2013.5570","volume":"22","author":"HA Park","year":"2015","unstructured":"Park HA, Licznerski P, Alavian KN, Shanabrough M, Jonas EA (2015) Bcl-xL is necessary for neurite outgrowth in hippocampal neurons. Antioxid Redox Signal 22:93\u2013108","journal-title":"Antioxid Redox Signal"},{"key":"1834_CR47","doi-asserted-by":"publisher","first-page":"284","DOI":"10.1186\/s12974-016-0751-z","volume":"13","author":"T Park","year":"2016","unstructured":"Park T, Chen H, Kevala K, Lee JW, Kim HY (2016) N-Docosahexaenoylethanolamine ameliorates LPS-induced neuroinflammation via cAMP\/PKA-dependent signaling. J Neuroinflamm 13:284","journal-title":"J Neuroinflamm"},{"key":"1834_CR48","doi-asserted-by":"publisher","first-page":"3019","DOI":"10.3390\/molecules23113019","volume":"23","author":"HA Park","year":"2018","unstructured":"Park HA, Broman K, Stumpf A, Kazyak S, Jonas EA (2018) Nutritional regulators of Bcl-xL in the brain. Molecules 23:3019","journal-title":"Molecules"},{"key":"1834_CR49","first-page":"2528","volume":"9","author":"AM Petros","year":"2000","unstructured":"Petros AM, Nettesheim DG, Wang Y, Olejniczak ET, Meadows RP, Mack J, Swift K, Matayoshi ED, Zhang H, Thompson CB, Fesik SW (2000) Rationale for Bcl-xL\/Bad peptide complex formation from structure, mutagenesis, and biophysical studies. Protein Sci 9:2528\u20132534","journal-title":"Protein Sci"},{"key":"1834_CR50","doi-asserted-by":"publisher","first-page":"756","DOI":"10.1038\/s41598-020-80818-9","volume":"11","author":"AI Ponomarenko","year":"2021","unstructured":"Ponomarenko AI, Tyrtyshnaia AA, Pislyagin EA, Dyuizen IV, Sultanov RM, Manzhulo IV (2021) N-docosahexaenoylethanolamine reduces neuroinflammation and cognitive impairment after mild traumatic brain injury in rats. Sci Rep 11:756","journal-title":"Sci Rep"},{"key":"1834_CR51","doi-asserted-by":"publisher","first-page":"538","DOI":"10.3390\/md20080538","volume":"20","author":"A Ponomarenko","year":"2022","unstructured":"Ponomarenko A, Tyrtyshnaia A, Ivashkevich D, Ermolenko E, Dyuizen I, Manzhulo I (2022) Synaptamide modulates astroglial activity in mild traumatic brain injury. Mar Drugs 20:538","journal-title":"Mar Drugs"},{"key":"1834_CR52","doi-asserted-by":"publisher","first-page":"779","DOI":"10.1038\/s41586-022-04580-w","volume":"604","author":"X Qu","year":"2022","unstructured":"Qu X, Qiu N, Wang M, Zhang B, Du J, Zhong Z, Xu W, Chu X, Ma L, Yi C, Han S, Shui W, Zhao Q, Wu B (2022) Structural basis of tethered agonism of the adhesion GPCRs ADGRD1 and ADGRF1. Nature 604:779\u2013785","journal-title":"Nature"},{"key":"1834_CR53","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1083\/jcb.124.1.1","volume":"124","author":"JC Reed","year":"1994","unstructured":"Reed JC (1994) Bcl-2 and the regulation of programmed cell death. J Cell Biol 124:1\u20136","journal-title":"J Cell Biol"},{"key":"1834_CR54","doi-asserted-by":"publisher","first-page":"1663","DOI":"10.1002\/glia.23336","volume":"66","author":"B Rodriguez-Grande","year":"2018","unstructured":"Rodriguez-Grande B, Obenaus A, Ichkova A, Aussudre J, Bessy T, Barse E, Hiba B, Catheline G, Barri\u00e8re G, Badaut J (2018) Gliovascular changes precede white matter damage and long-term disorders in juvenile mild closed head injury. Glia 66:1663\u20131677","journal-title":"Glia"},{"key":"1834_CR55","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1016\/j.brainres.2013.10.047","volume":"13","author":"E Rostami","year":"2014","unstructured":"Rostami E, Krueger F, Plantman S, Davidsson J, Agoston D, Grafman J, Risling M (2014) Alteration in BDNF and its receptors, full-length and truncated TrkB and p75(NTR) following penetrating traumatic brain injury. Brain Res 13:195\u2013205","journal-title":"Brain Res"},{"key":"1834_CR56","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1034\/j.1600-065X.2001.1800103.x","volume":"180","author":"A Sahu","year":"2001","unstructured":"Sahu A, Lambris JD (2001) Structure and biology of complement protein C3, a connecting link between innate and acquired immunity. Immunol Rev 180:35\u201348","journal-title":"Immunol Rev"},{"issue":"1","key":"1834_CR57","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1016\/j.emc.2022.09.014","volume":"41","author":"VR Salasky","year":"2023","unstructured":"Salasky VR, Chang WW (2023) Neurotrauma update. Emerg Med Clin N Am 41(1):19\u201333","journal-title":"Emerg Med Clin N Am"},{"key":"1834_CR58","first-page":"50079","volume":"19","author":"S Schildge","year":"2013","unstructured":"Schildge S, Bohrer C, Beck K, Schachtrup C (2013) Isolation and culture of mouse cortical astrocytes. J vis Exp 19:50079","journal-title":"J vis Exp"},{"key":"1834_CR59","doi-asserted-by":"publisher","first-page":"517","DOI":"10.1016\/j.cytogfr.2015.07.014","volume":"26","author":"NA Sims","year":"2015","unstructured":"Sims NA (2015) Cardiotrophin-like cytokine factor 1 (CLCF1) and neuropoietin (NP) signalling and their roles in development, adulthood, cancer and degenerative disorders. Cytokine Growth Factor Rev 26:517\u2013522","journal-title":"Cytokine Growth Factor Rev"},{"key":"1834_CR60","doi-asserted-by":"publisher","first-page":"758","DOI":"10.1016\/j.it.2020.07.004","volume":"41","author":"MV Sofroniew","year":"2020","unstructured":"Sofroniew MV (2020) Astrocyte reactivity: subtypes, states, and functions in CNS innate immunity. Trends Immunol 41:758\u2013770","journal-title":"Trends Immunol"},{"key":"1834_CR61","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchemneu.2023.102361","volume":"134","author":"A Starinets","year":"2023","unstructured":"Starinets A, Ponomarenko A, Tyrtyshnaia A, Manzhulo I (2023) Synaptamide modulates glial and neurotransmitter activity in the spinal cord during neuropathic pain. J Chem Neuroanat 134:102361","journal-title":"J Chem Neuroanat"},{"key":"1834_CR62","doi-asserted-by":"publisher","first-page":"10014","DOI":"10.3390\/ijms241210014","volume":"24","author":"A Tyrtyshnaia","year":"2023","unstructured":"Tyrtyshnaia A, Manzhulo O, Manzhulo I (2023) Synaptamide ameliorates hippocampal neurodegeneration and glial activation in mice with traumatic brain injury. Int J Mol Sci 24:10014","journal-title":"Int J Mol Sci"},{"key":"1834_CR63","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1006\/cyto.2002.1006","volume":"18","author":"A Uemura","year":"2002","unstructured":"Uemura A, Takizawa T, Ochiai W, Yanagisawa M, Nakashima K, Taga T (2002) Cardiotrophin-like cytokine induces astrocyte differentiation of fetal neuroepithelial cells via activation of STAT3. Cytokine 18:1\u20137","journal-title":"Cytokine"},{"key":"1834_CR64","doi-asserted-by":"publisher","first-page":"2563","DOI":"10.4081\/ejh.2016.2563","volume":"60","author":"L Vinci","year":"2016","unstructured":"Vinci L, Ravarino A, Fanos V, Naccarato AG, Senes G, Gerosa C et al (2016) Immunohistochemical markers of neural progenitor cells in the early embryonic human cerebral cortex. Eur J Histochem 60:2563","journal-title":"Eur J Histochem"},{"key":"1834_CR65","doi-asserted-by":"publisher","first-page":"325","DOI":"10.1016\/j.cytogfr.2004.04.002","volume":"15","author":"G Vlotides","year":"2004","unstructured":"Vlotides G, Zitzmann K, Stalla GK, Auernhammer CJ (2004) Novel neurotrophin-1\/B cell-stimulating factor-3 (NNT-1\/BSF-3)\/cardiotrophin-like cytokine (CLC)- a novel gp130 cytokine with pleiotropic functions. Cytokine Growth Factor Rev 15:325\u2013336","journal-title":"Cytokine Growth Factor Rev"},{"key":"1834_CR66","doi-asserted-by":"publisher","first-page":"1597","DOI":"10.1523\/JNEUROSCI.2469-20.2020","volume":"41","author":"KG Witcher","year":"2021","unstructured":"Witcher KG, Bray CE, Chunchai T, Zhao F, O\u2019Neil SM, Gordillo AJ, Campbell WA, McKim DB, Liu X, Dziabis JE, Quan N, Eiferman DS, Fischer AJ, Kokiko-Cochran ON, Askwith C, Godbout JP (2021) Traumatic brain injury causes chronic cortical inflammation and neuronal dysfunction mediated by microglia. J Neurosci 41:1597\u20131616","journal-title":"J Neurosci"},{"key":"1834_CR67","doi-asserted-by":"publisher","first-page":"972","DOI":"10.1007\/s11064-020-02993-5","volume":"45","author":"S W\u00f3jtowicz","year":"2020","unstructured":"W\u00f3jtowicz S, Strosznajder AK, Je\u017cyna M, Strosznajder JB (2020) The novel role of PPAR alpha in the brain: promising target in therapy of Alzheimer\u2019s disease and other neurodegenerative disorders. Neurochem Res 45:972\u2013988","journal-title":"Neurochem Res"},{"key":"1834_CR68","doi-asserted-by":"publisher","first-page":"1167","DOI":"10.1177\/44.10.8813082","volume":"44","author":"HK Wolf","year":"1996","unstructured":"Wolf HK, Buslei R, Schmidt-Kastner R, Schmidt-Kastner PK, Pietsch T, Wiestler OD, Bl\u00fcmcke I (1996) NeuN: a useful neuronal marker for diagnostic histopathology. J Histochem Cytochem 44:1167\u20131171","journal-title":"J Histochem Cytochem"},{"issue":"1","key":"1834_CR69","doi-asserted-by":"publisher","first-page":"257","DOI":"10.3390\/jcm9010257","volume":"9","author":"J Wook","year":"2020","unstructured":"Wook J (2020) Regulation of BDNF-TrkB signaling and potential therapeutic strategies for Parkinson\u2019s disease. J Clin Med 9(1):257","journal-title":"J Clin Med"},{"issue":"11","key":"1834_CR70","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0113397","volume":"9","author":"CH Wu","year":"2014","unstructured":"Wu CH, Hung TH, Chen CC, Ke CH, Lee CY, Wang PY, Chen SF (2014) Post-injury treatment with 7,8-dihydroxyflavone, a TrkB receptor agonist, protects against experimental traumatic brain injury via PI3K\/Akt signaling. PLoS ONE 9(11):e113397","journal-title":"PLoS ONE"},{"key":"1834_CR71","doi-asserted-by":"publisher","first-page":"9198","DOI":"10.1128\/MCB.24.20.9198-9206.2004","volume":"24","author":"B Xu","year":"2004","unstructured":"Xu B, deWaal RM, Mor-Vaknin N, Hibbard C, Markovitz DM, Kahn ML (2004) The endothelial cell-specific antibody PAL-E identifies a secreted form of Vimentin in the blood vasculature. Mol Cell Biol 24:9198\u20139206","journal-title":"Mol Cell Biol"},{"key":"1834_CR72","doi-asserted-by":"publisher","first-page":"6391","DOI":"10.1523\/JNEUROSCI.6221-11.2012","volume":"32","author":"JL Zamanian","year":"2012","unstructured":"Zamanian JL, Xu L, Foo LC, Nouri N, Zhou L, Giffard RG, Barres BA (2012) Genomic analysis of reactive astrogliosis. J Neurosci 32:6391\u20136410","journal-title":"J Neurosci"}],"container-title":["Inflammopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10787-025-01834-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10787-025-01834-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10787-025-01834-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,7]],"date-time":"2025-09-07T01:50:19Z","timestamp":1757209819000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10787-025-01834-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7,5]]},"references-count":71,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2025,8]]}},"alternative-id":["1834"],"URL":"https:\/\/doi.org\/10.1007\/s10787-025-01834-7","relation":{},"ISSN":["0925-4692","1568-5608"],"issn-type":[{"value":"0925-4692","type":"print"},{"value":"1568-5608","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,7,5]]},"assertion":[{"value":"9 June 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 June 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 July 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"All experimental manipulations were approved by the Animal Ethics Committee of A.V. Zhirmunsky National Scientific Center of Marine Biology, Far Eastern Branch, Russian Academy of Sciences (No. 1 of 26\/03\/2023), in accordance with the international standards of European Directive 2010\/63\/EU.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical statement"}}]}}