{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,17]],"date-time":"2025-11-17T20:51:19Z","timestamp":1763412679842,"version":"3.45.0"},"reference-count":31,"publisher":"Springer Science and Business Media LLC","issue":"11","license":[{"start":{"date-parts":[[2025,10,6]],"date-time":"2025-10-06T00:00:00Z","timestamp":1759708800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,10,6]],"date-time":"2025-10-06T00:00:00Z","timestamp":1759708800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100004484","name":"Tehran University of Medical Sciences and Health Services","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004484","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Inflammopharmacol"],"published-print":{"date-parts":[[2025,11]]},"DOI":"10.1007\/s10787-025-01842-7","type":"journal-article","created":{"date-parts":[[2025,10,6]],"date-time":"2025-10-06T01:23:25Z","timestamp":1759713805000},"page":"6657-6667","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Chloroquine protects against mesenteric ischemia: insights into the role of nitrergic and opioidergic systems"],"prefix":"10.1007","volume":"33","author":[{"given":"Seyed Amir Mahdi","family":"Emami","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amirabbas","family":"Mohammadi Hamaneh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Moein","family":"Ghasemi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alireza","family":"Abdollahi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kimiya","family":"Jouyban","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Razieh","family":"Mohammad Jafari","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amir Hossein","family":"Abdolghaffari","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5656-644X","authenticated-orcid":false,"given":"Ahmad Reza","family":"Dehpour","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,10,6]]},"reference":[{"key":"1842_CR1","doi-asserted-by":"publisher","DOI":"10.1007\/s00210-025-03837-1","author":"AO Abdel-Zaher","year":"2025","unstructured":"Abdel-Zaher AO, Bakr MH, Gad YH, Abdelhafez AT (2025) Novel mechanistic insights of the potential role of gasotransmitters and autophagy in the protective effect of metformin against hepatic ischemia\/reperfusion injury in rats. Naunyn Schmiedebergs Arch Pharmacol. https:\/\/doi.org\/10.1007\/s00210-025-03837-1","journal-title":"Naunyn Schmiedebergs Arch Pharmacol"},{"key":"1842_CR2","doi-asserted-by":"publisher","first-page":"e100","DOI":"10.1002\/bjs.9330","volume":"101","author":"S Acosta","year":"2014","unstructured":"Acosta S, Bj\u00f6rck M (2014) Modern treatment of acute mesenteric ischaemia. J British Surg 101:e100\u2013e108","journal-title":"J British Surg"},{"key":"1842_CR3","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s003950050001","volume":"95","author":"KA Aitchison","year":"2000","unstructured":"Aitchison KA, Baxter GF, Moneeb Awan M, Smith RM, Yellon DM, Opie LH (2000) Opposing effects on infarction of delta and kappa opioid receptor activation in the isolated rat heart: implications for ischemic preconditioning. Basic Res Cardiol 95:1\u201310","journal-title":"Basic Res Cardiol"},{"key":"1842_CR4","doi-asserted-by":"publisher","first-page":"e1219","DOI":"10.1097\/CCM.0000000000001959","volume":"44","author":"C Chen","year":"2016","unstructured":"Chen C, Xi C, Liang X, Ma J, Su D, Abel T, Liu R (2016) The role of \u03ba opioid receptor in brain ischemia. Crit Care Med 44:e1219\u2013e1225","journal-title":"Crit Care Med"},{"key":"1842_CR5","doi-asserted-by":"publisher","first-page":"959","DOI":"10.1056\/NEJMra1503884","volume":"374","author":"DG Clair","year":"2016","unstructured":"Clair DG, Beach JM (2016) Mesenteric ischemia. N Engl J Med 374:959\u2013968","journal-title":"N Engl J Med"},{"key":"1842_CR6","doi-asserted-by":"publisher","first-page":"e694","DOI":"10.1038\/cddis.2013.225","volume":"4","author":"H Fang","year":"2013","unstructured":"Fang H, Liu A, Dahmen U, Dirsch O (2013) Dual role of chloroquine in liver ischemia reperfusion injury: reduction of liver damage in early phase, but aggravation in late phase. Cell Death Dis 4:e694\u2013e694","journal-title":"Cell Death Dis"},{"key":"1842_CR7","doi-asserted-by":"publisher","first-page":"G374","DOI":"10.1152\/ajpgi.00386.2016","volume":"312","author":"V Filpa","year":"2017","unstructured":"Filpa V, Carpanese E, Marchet S, Pirrone C, Conti A, Rainero A, Moro E, Chiaravalli AM, Zucchi I, Moriondo A (2017) Nitric oxide regulates homeoprotein OTX1 and OTX2 expression in the rat myenteric plexus after intestinal ischemia-reperfusion injury. Am J Physiol Gastrointest Liver Physiol 312:G374\u2013G389","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"1842_CR8","doi-asserted-by":"publisher","first-page":"595","DOI":"10.1172\/JCI1052","volume":"102","author":"D Ghigo","year":"1998","unstructured":"Ghigo D, Aldieri E, Todde R, Costamagna C, Garbarino G, Pescarmona G, Bosia A (1998) Chloroquine stimulates nitric oxide synthesis in murine, porcine, and human endothelial cells. J Clin Investig 102:595\u2013605","journal-title":"J Clin Investig"},{"key":"1842_CR9","doi-asserted-by":"publisher","first-page":"847","DOI":"10.1111\/jphp.12041","volume":"65","author":"F Jing","year":"2013","unstructured":"Jing F, Liu M, Yang N, Liu Y, Li X, Li J (2013) Relaxant effect of chloroquine in rat ileum: possible involvement of nitric oxide and BKCa. J Pharm Pharmacol 65:847\u2013854","journal-title":"J Pharm Pharmacol"},{"key":"1842_CR10","doi-asserted-by":"publisher","first-page":"1352","DOI":"10.3390\/ijms26031352","volume":"26","author":"Y Liang","year":"2025","unstructured":"Liang Y, Ornatowski W, Lu Q, Sun X, Yegambaram M, Feng A, Dong Y, Aggarwal S, Unwalla HJ, Fineman JR (2025) Chloroquine restores eNOS signaling in shunt endothelial cells via inhibiting eNOS uncoupling. Int J Mol Sci 26:1352","journal-title":"Int J Mol Sci"},{"key":"1842_CR11","doi-asserted-by":"publisher","first-page":"416","DOI":"10.26502\/fccm.92920278","volume":"6","author":"KM Marsh","year":"2022","unstructured":"Marsh KM, Rastogi R, Zhang A, Wu D, Kron IL, Yang Z (2022) Hydroxychloroquine attenuates myocardial ischemic and post-ischemic reperfusion injury by inhibiting the toll-like receptor 9\u2013type I interferon pathway. Cardiol Cardiovasc Med 6:416","journal-title":"Cardiol Cardiovasc Med"},{"key":"1842_CR12","doi-asserted-by":"publisher","first-page":"314","DOI":"10.5603\/CJ.a2016.0062","volume":"24","author":"B Mei","year":"2017","unstructured":"Mei B, Li W, Cheng X, Liu X, Gu E, Zhang Y (2017) Activating mu-opioid receptors in the spinal cord mediates the cardioprotective effect of remote preconditioning of trauma. Cardiol J 24:314\u2013323","journal-title":"Cardiol J"},{"key":"1842_CR13","doi-asserted-by":"publisher","first-page":"935","DOI":"10.1590\/s0102-865020170110000005","volume":"32","author":"TRRD Oliveira","year":"2017","unstructured":"Oliveira TRRD, Oliveira GFD, Sim\u00f5es RS, Feitosa SM, Tikazawa EH, Monteiro HP, Fagundes DJ, Taha MO (2017) The expression of endothelial and inducible nitric oxide synthase and apoptosis in intestinal ischemia and reperfusion injury under the action of ischemic preconditioning and pentoxifylline. Acta Cirurgica Brasileira 32:935\u2013948","journal-title":"Acta Cirurgica Brasileira"},{"key":"1842_CR14","first-page":"39","volume":"60","author":"T Perecko","year":"2014","unstructured":"Perecko T, Kassab R, Vasicek O, Pekarov\u00e1 M, Jancinova V, Lojek A (2014) The effects of chloroquine and hydroxychloroquine on nitric oxide production in RAW 264.7 and bone marrow-derived macrophages. Folia Biol 60:39\u201344","journal-title":"Folia Biol"},{"key":"1842_CR15","doi-asserted-by":"publisher","first-page":"1168","DOI":"10.1159\/000430240","volume":"37","author":"CR Pestana","year":"2015","unstructured":"Pestana CR, Oishi JC, Salistre-Ara\u00fajo HS, Rodrigues GJ (2015) Inhibition of autophagy by chloroquine stimulates nitric oxide production and protects endothelial function during serum deprivation. Cell Physiol Biochem 37:1168\u20131177","journal-title":"Cell Physiol Biochem"},{"issue":"6","key":"1842_CR16","doi-asserted-by":"publisher","first-page":"1307","DOI":"10.1016\/s0041-1345(00)01238-0","volume":"32","author":"J Quaedackers","year":"2000","unstructured":"Quaedackers J, Beuk R, Bennet L, Charlton A, Oude Egbrink M, Gunn A, Heineman E (2000) An evaluation of methods for grading histologic injury following ischemia\/reperfusion of the small bowel. Transplant Proc 32(6):1307\u20131310. https:\/\/doi.org\/10.1016\/s0041-1345(00)01238-0","journal-title":"Transplant Proc"},{"key":"1842_CR17","doi-asserted-by":"publisher","first-page":"219","DOI":"10.15171\/bi.2017.26","volume":"7","author":"A Rezabakhsh","year":"2017","unstructured":"Rezabakhsh A, Montazersaheb S, Nabat E, Hassanpour M, Montaseri A, Malekinejad H, Movassaghpour AA, Rahbarghazi R, Garjani A (2017) Effect of hydroxychloroquine on oxidative\/nitrosative status and angiogenesis in endothelial cells under high glucose condition. BioImpacts 7:219","journal-title":"BioImpacts"},{"key":"1842_CR18","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1016\/j.jss.2004.01.006","volume":"119","author":"MA Romano","year":"2004","unstructured":"Romano MA, McNish R, Seymour EM, Traynor JR, Bolling SF (2004) Differential effects of opioid peptides on myocardial ischemic tolerance. J Surg Res 119:46\u201350","journal-title":"J Surg Res"},{"key":"1842_CR19","doi-asserted-by":"publisher","first-page":"2146","DOI":"10.1002\/jnr.23108","volume":"90","author":"F Saccani","year":"2012","unstructured":"Saccani F, Anselmi L, Jaramillo I, Bertoni S, Barocelli E, Sternini C (2012) Protective role of \u03bc opioid receptor activation in intestinal inflammation induced by mesenteric ischemia\/reperfusion in mice. J Neurosci Res 90:2146\u20132153","journal-title":"J Neurosci Res"},{"key":"1842_CR20","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s10020-020-00190-2","volume":"26","author":"U Sachdev","year":"2020","unstructured":"Sachdev U, Ferrari R, Cui X, Pius A, Sahu A, Reynolds M, Liao H, Sun P, Shinde S, Ambrosio F (2020) Caspase1\/11 signaling affects muscle regeneration and recovery following ischemia, and can be modulated by chloroquine. Mol Med 26:1\u201317","journal-title":"Mol Med"},{"key":"1842_CR21","doi-asserted-by":"publisher","first-page":"548","DOI":"10.1016\/j.surg.2015.07.028","volume":"159","author":"J-T Shen","year":"2016","unstructured":"Shen J-T, Li Y-S, Xia Z-Q, Wen S-H, Yao X, Yang W-J, Li C, Liu K-X (2016) Remifentanil preconditioning protects the small intestine against ischemia\/reperfusion injury via intestinal \u03b4-and \u03bc-opioid receptors. Surgery 159:548\u2013559","journal-title":"Surgery"},{"key":"1842_CR22","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s43094-025-00781-y","volume":"11","author":"MM Sherif","year":"2025","unstructured":"Sherif MM, El-Abhar HS, Fawzy HM, Gad AM, Abdallah DM (2025) Repurposing the antimalarial chloroquine: a potential therapy for hepatic injury in a rat model of hindlimb ischemia\u2013reperfusion by modulating apoptosis, autophagy, inflammation, and oxidative stress. Futur J Pharm Sci 11:1\u201315","journal-title":"Futur J Pharm Sci"},{"key":"1842_CR23","doi-asserted-by":"publisher","first-page":"351","DOI":"10.1038\/s41419-018-0378-3","volume":"9","author":"T-T Tang","year":"2018","unstructured":"Tang T-T, Lv L-L, Pan M-M, Wen Y, Wang B, Li Z-L, Wu M, Wang F-M, Crowley SD, Liu B-C (2018) Hydroxychloroquine attenuates renal ischemia\/reperfusion injury by inhibiting cathepsin mediated NLRP3 inflammasome activation. Cell Death Dis 9:351","journal-title":"Cell Death Dis"},{"key":"1842_CR24","doi-asserted-by":"publisher","first-page":"170","DOI":"10.1038\/s41401-018-0053-3","volume":"40","author":"X Wang","year":"2019","unstructured":"Wang X, Sun Z-J, Wu J-L, Quan W-Q, Xiao W-D, Chew H, Jiang C-M, Li D (2019) Naloxone attenuates ischemic brain injury in rats through suppressing the NIK\/IKK\u03b1\/NF-\u03baB and neuronal apoptotic pathways. Acta Pharmacol Sin 40:170\u2013179","journal-title":"Acta Pharmacol Sin"},{"key":"1842_CR25","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1006\/jsre.1999.5795","volume":"89","author":"DT Ward","year":"2000","unstructured":"Ward DT, Lawson SA, Gallagher CM, Conner WC, Shea-Donohue T (2000) Sustained nitric oxide production via L-arginine administration ameliorates effects of intestinal ischemia\u2013reperfusion. J Surg Res 89:13\u201319","journal-title":"J Surg Res"},{"key":"1842_CR26","doi-asserted-by":"publisher","first-page":"4155","DOI":"10.1111\/bph.13990","volume":"174","author":"K Wu","year":"2017","unstructured":"Wu K, Zhang Q, Wu X, Lu W, Tang H, Liang Z, Gu Y, Song S, Ayon RJ, Wang Z (2017) Chloroquine is a potent pulmonary vasodilator that attenuates hypoxia-induced pulmonary hypertension. Br J Pharmacol 174:4155\u20134172","journal-title":"Br J Pharmacol"},{"key":"1842_CR27","doi-asserted-by":"publisher","first-page":"357","DOI":"10.1007\/s11596-013-1124-9","volume":"33","author":"L Zhang","year":"2013","unstructured":"Zhang L, Chen Y, Wang L, Chen X-P, Zhang W-G, Wang C-Y, Wu H-S (2013) Chloroquine relieves acute lung injury in rats with acute hemorrhagic necrotizing pancreatitis. J Huazhong Univ Sci Technolog Med Sci 33:357\u2013360","journal-title":"J Huazhong Univ Sci Technolog Med Sci"},{"key":"1842_CR28","doi-asserted-by":"publisher","first-page":"746","DOI":"10.1016\/j.healun.2014.12.008","volume":"34","author":"D Zhang","year":"2015","unstructured":"Zhang D, Li C, Zhou J, Song Y, Fang X, Ou J, Li J, Bai C (2015) Autophagy protects against ischemia\/reperfusion-induced lung injury through alleviating blood\u2013air barrier damage. J Heart Lung Transplant 34:746\u2013755","journal-title":"J Heart Lung Transplant"},{"key":"1842_CR29","doi-asserted-by":"publisher","first-page":"1965","DOI":"10.1159\/000485886","volume":"44","author":"Y Zhou","year":"2018","unstructured":"Zhou Y, Wang Y, Wang X, Tian X, Zhang S, Yang F, Guo H, Fan R, Feng N, Jia M (2018) The protective effects of \u039a-opioid receptor stimulation in hypoxic pulmonary hypertension involve inhibition of autophagy through the AMPK-MTOR pathway. Cell Physiol Biochem 44:1965\u20131979","journal-title":"Cell Physiol Biochem"},{"key":"1842_CR30","doi-asserted-by":"publisher","first-page":"410","DOI":"10.1111\/1751-2980.13307","volume":"25","author":"L Zhou","year":"2024","unstructured":"Zhou L, Cai SZ, Dong LL (2024) Recent advances in pathogenesis, diagnosis, and therapeutic approaches for digestive system involvement in systemic lupus erythematosus. J Dig Dis 25:410\u2013423","journal-title":"J Dig Dis"},{"key":"1842_CR31","doi-asserted-by":"publisher","first-page":"953","DOI":"10.1016\/j.bbrc.2019.05.068","volume":"514","author":"Y Zuo","year":"2019","unstructured":"Zuo Y, Zhang J, Cheng X, Li J, Yang Z, Liu X, Gu E, Zhang Y (2019) Enhanced autophagic flux contributes to cardioprotection of remifentanil postconditioning after hypoxia\/reoxygenation injury in H9c2 cardiomyocytes. Biochem Biophys Res Commun 514:953\u2013959","journal-title":"Biochem Biophys Res Commun"}],"container-title":["Inflammopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10787-025-01842-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10787-025-01842-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10787-025-01842-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,17]],"date-time":"2025-11-17T19:03:27Z","timestamp":1763406207000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10787-025-01842-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10,6]]},"references-count":31,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2025,11]]}},"alternative-id":["1842"],"URL":"https:\/\/doi.org\/10.1007\/s10787-025-01842-7","relation":{},"ISSN":["0925-4692","1568-5608"],"issn-type":[{"type":"print","value":"0925-4692"},{"type":"electronic","value":"1568-5608"}],"subject":[],"published":{"date-parts":[[2025,10,6]]},"assertion":[{"value":"23 March 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 June 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 October 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors have no relevant financial or non-financial interests to disclose.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"All animals involved in this study were handled in accordance with the guidelines approved by the Animal Ethics Committee of Tehran University of Medical Sciences (IR.TUMS.VCR.REC. No.03-2-101-73303) and the EU Directive 2010\/63\/EU for animal experiments.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}}]}}