{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T16:17:14Z","timestamp":1791476234279,"version":"4.3.4"},"reference-count":52,"publisher":"Springer Science and Business Media LLC","issue":"8","license":[{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Inflammopharmacol"],"published-print":{"date-parts":[[2025,8]]},"DOI":"10.1007\/s10787-025-01874-z","type":"journal-article","created":{"date-parts":[[2025,8,4]],"date-time":"2025-08-04T18:25:07Z","timestamp":1754331907000},"page":"4499-4518","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Anti-arthritic and immunomodulatory effects of geniposide: a systematic review and meta-analysis of preclinical studies"],"prefix":"10.1007","volume":"33","author":[{"given":"Muhammad Muzammil","family":"Nazir","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7026-670X","authenticated-orcid":false,"given":"Asma","family":"Ashraf","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammad Mubashir","family":"Nazir","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad Rameez","family":"Hashmi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,8,4]]},"reference":[{"issue":"15","key":"1874_CR1","doi-asserted-by":"publisher","first-page":"8140","DOI":"10.3390\/ijms23158140","volume":"23","author":"M Arleevskaya","year":"2022","unstructured":"Arleevskaya M, Takha E, Petrov S, Kazarian G, Renaudineau Y, Brooks W, Larionova R, Korovina M, Valeeva A, Shuralev E (2022) Interplay of environmental, individual and genetic factors in rheumatoid arthritis provocation. Int J Mol Sci 23(15):8140","journal-title":"Int J Mol Sci"},{"key":"1874_CR2","doi-asserted-by":"publisher","DOI":"10.1016\/j.prp.2025.155945","author":"MZA Begh","year":"2025","unstructured":"Begh MZA, Zehravi M, Reza F, Sweilam SH, Shanmugarajan TS, Arjun UVNV, Devi K, Ethiraj S, Kumar VS, Thilagam E (2025) Therapeutic potential of phytocompounds in rheumatoid arthritis: molecular insights and clinical applications. Pathology. https:\/\/doi.org\/10.1016\/j.prp.2025.155945","journal-title":"Pathology"},{"issue":"3","key":"1874_CR3","doi-asserted-by":"publisher","first-page":"1047","DOI":"10.1007\/s10787-022-00975-3","volume":"30","author":"Y Bu","year":"2022","unstructured":"Bu Y, Wu H, Deng R, Wang Y (2022) The anti-angiogenesis mechanism of Geniposide on rheumatoid arthritis is related to the regulation of PTEN. Inflammopharmacology 30(3):1047\u20131062","journal-title":"Inflammopharmacology"},{"key":"1874_CR4","doi-asserted-by":"crossref","unstructured":"Bu Y, Sun M, Zhang H, Deng R, Wang Y (2020) Intestinal Absorption of Geniposide and Inhibition of Transporter-P-GP Across the Caco-2 Monolayer.","DOI":"10.21203\/rs.3.rs-61518\/v1"},{"key":"1874_CR5","doi-asserted-by":"publisher","first-page":"2184","DOI":"10.1007\/s10753-018-0861-0","volume":"41","author":"L Cai","year":"2018","unstructured":"Cai L, Li C-M, Tang W-J, Liu M-M, Chen W-N, Qiu Y-Y, Li R (2018) Therapeutic effect of penta-acetyl geniposide on adjuvant-induced arthritis in rats: involvement of inducing synovial apoptosis and inhibiting NF-\u03baB signal pathway. Inflammation 41:2184\u20132195","journal-title":"Inflammation"},{"issue":"6","key":"1874_CR6","doi-asserted-by":"publisher","first-page":"2232","DOI":"10.1007\/s10753-021-01495-y","volume":"44","author":"L Cai","year":"2021","unstructured":"Cai L, Mu Y-R, Liu M-M, Zhou M-Y, Meng B, Liu F-Y, Li R (2021) Penta-acetyl Geniposide suppresses migration, invasion, and inflammation of TNF-\u03b1-stimulated rheumatoid arthritis fibroblast-like synoviocytes involving wnt\/\u03b2-catenin signaling pathway. Inflammation 44(6):2232\u20132245","journal-title":"Inflammation"},{"issue":"1","key":"1874_CR7","doi-asserted-by":"publisher","first-page":"102","DOI":"10.1016\/j.intimp.2014.11.017","volume":"24","author":"J-Y Chen","year":"2015","unstructured":"Chen J-Y, Wu H, Li H, Hu S-L, Dai M-M, Chen J (2015a) Anti-inflammatory effects and pharmacokinetics study of geniposide on rats with adjuvant arthritis. Int Immunopharmacol 24(1):102\u2013109","journal-title":"Int Immunopharmacol"},{"key":"1874_CR8","doi-asserted-by":"publisher","first-page":"122","DOI":"10.1016\/j.jpba.2015.01.044","volume":"108","author":"J Chen","year":"2015","unstructured":"Chen J, Wu H, Xu G-B, Dai M-M, Hu S-L, Sun L-L, Wang W, Wang R, Li S-P, Li G-Q (2015b) Determination of geniposide in adjuvant arthritis rat plasma by ultra-high performance liquid chromatography tandem mass spectrometry method and its application to oral bioavailability and plasma protein binding ability studies. J Pharm Biomed Anal 108:122\u2013128","journal-title":"J Pharm Biomed Anal"},{"issue":"1","key":"1874_CR9","volume":"2018","author":"Y Chen","year":"2018","unstructured":"Chen Y, Shou K, Gong C, Yang H, Yang Y, Bao T (2018) Anti-inflammatory effect of geniposide on osteoarthritis by suppressing the activation of P38 MAPK signaling pathway. BioMed Res Int 2018(1):8384576","journal-title":"BioMed Res Int"},{"issue":"1","key":"1874_CR10","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1016\/j.intimp.2014.02.021","volume":"20","author":"M-M Dai","year":"2014","unstructured":"Dai M-M, Wu H, Li H, Chen J, Chen J-Y, Hu S-L, Shen C (2014) Effects and mechanisms of Geniposide on rats with adjuvant arthritis. Int Immunopharmacol 20(1):46\u201353","journal-title":"Int Immunopharmacol"},{"key":"1874_CR11","doi-asserted-by":"publisher","first-page":"105","DOI":"10.3389\/fphar.2018.00105","volume":"9","author":"R Deng","year":"2018","unstructured":"Deng R, Li F, Wu H, Wang W-Y, Dai L, Zhang Z-R, Fu J (2018) Anti-inflammatory mechanism of geniposide: inhibiting the hyperpermeability of fibroblast-like synoviocytes via the RhoA\/p38MAPK\/NF-\u03baB\/F-actin signal pathway. Front Pharmacol 9:105","journal-title":"Front Pharmacol"},{"key":"1874_CR12","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2022.175271","volume":"933","author":"P-R Gan","year":"2022","unstructured":"Gan P-R, Wang R-H, Deng R, Wu H, Bu Y-H, Chen F-Y, Dong X-T, Ke J-T (2022) Geniposide inhibits SphK1 membrane targeting to restore macrophage polarization balance in collagen-induced arthritis mice. Eur J Pharmacol 933:175271","journal-title":"Eur J Pharmacol"},{"key":"1874_CR13","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaut.2024.103214","volume":"146","author":"Q Geng","year":"2024","unstructured":"Geng Q, Xu J, Cao X, Wang Z, Jiao Y, Diao W, Wang X, Wang Z, Zhang M, Zhao L (2024) PPARG-mediated autophagy activation alleviates inflammation in rheumatoid arthritis. J Autoimmun 146:103214","journal-title":"J Autoimmun"},{"issue":"4","key":"1874_CR14","doi-asserted-by":"publisher","first-page":"965","DOI":"10.1007\/s10787-021-00800-3","volume":"29","author":"SSA Ibrahim","year":"2021","unstructured":"Ibrahim SSA, Huttunen KM (2021) Orchestrated modulation of rheumatoid arthritis via crosstalking intracellular signaling pathways. Inflammopharmacology 29(4):965\u2013974","journal-title":"Inflammopharmacology"},{"key":"1874_CR15","doi-asserted-by":"crossref","unstructured":"Jin Z, Zhao H, Luo Y, Li J, Pi J, He W, Yan J, Yang P (2021) Geniposide achieved an anti-inflammatory effect through the NF-\u03baB\/HIF-1\u03b1 signaling pathway mediated by VEGFA and HMOX1 genes. SSRN Electronic J.","DOI":"10.2139\/ssrn.3940896"},{"key":"1874_CR16","doi-asserted-by":"publisher","first-page":"733","DOI":"10.1007\/s12272-012-0418-y","volume":"35","author":"MJ Kang","year":"2012","unstructured":"Kang MJ, Khanal T, Kim HG, Lee DH, Yeo HK, Lee YS, Ahn YT, Kim DH, Jeong HG, Jeong TC (2012) Role of metabolism by human intestinal microflora in geniposide-induced toxicity in HepG2 cells. Arch Pharm Res 35:733\u2013738","journal-title":"Arch Pharm Res"},{"key":"1874_CR17","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2022.969408","volume":"13","author":"J-T Ke","year":"2022","unstructured":"Ke J-T, Zhang H, Bu Y-H, Gan P-R, Chen F-Y, Dong X-T, Wang Y, Wu H (2022) Metabonomic analysis of abnormal sphingolipid metabolism in rheumatoid arthritis synovial fibroblasts in hypoxia microenvironment and intervention of geniposide. Front Pharmacol 13:969408","journal-title":"Front Pharmacol"},{"issue":"5","key":"1874_CR18","doi-asserted-by":"publisher","first-page":"294","DOI":"10.1111\/bcpt.12113","volume":"113","author":"H Li","year":"2013","unstructured":"Li H, Wu H, Shen C, Chen JY, Hu SL, Wu H (2013) Comparative pharmacokinetics study after oral administration of geniposide in normal rats and adjuvant-induced arthritis rats by UPLC-MS\/MS. Basic Clin Pharmacol Toxicol 113(5):294\u2013299","journal-title":"Basic Clin Pharmacol Toxicol"},{"issue":"1","key":"1874_CR19","doi-asserted-by":"publisher","first-page":"91","DOI":"10.3390\/molecules23010091","volume":"23","author":"F Li","year":"2018","unstructured":"Li F, Dai M, Wu H, Deng R, Fu J, Zhang Z, Dai L, Wang W, Dai X, Zhan X (2018) Immunosuppressive effect of geniposide on mitogen-activated protein kinase signalling pathway and their cross-talk in fibroblast-like synoviocytes of adjuvant arthritis rats. Molecules 23(1):91","journal-title":"Molecules"},{"issue":"1","key":"1874_CR20","first-page":"435","volume":"18","author":"Z Li","year":"2019","unstructured":"Li Z, Qian J, Li J, Zhu C (2019) Knockdown of lncRNA-HOTAIR downregulates the drug-resistance of breast cancer cells to doxorubicin via the PI3K\/AKT\/mTOR signaling pathway. Exp Ther Med 18(1):435\u2013442","journal-title":"Exp Ther Med"},{"issue":"10","key":"1874_CR21","doi-asserted-by":"publisher","first-page":"3319","DOI":"10.3390\/molecules27103319","volume":"27","author":"L Liu","year":"2022","unstructured":"Liu L, Wu Q, Chen Y, Gu G, Gao R, Peng B, Wang Y, Li A, Guo J, Xu X (2022) Updated pharmacological effects, molecular mechanisms, and therapeutic potential of natural product geniposide. Molecules 27(10):3319","journal-title":"Molecules"},{"key":"1874_CR22","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2024.112082","volume":"133","author":"L Liu","year":"2024","unstructured":"Liu L, Zhang H, Tang X, Zhang M, Wu Y, Zhao Y, Lu C, Zhao R (2024) Geniposide ameliorates psoriatic skin inflammation by inhibiting the TLR4\/MyD88\/NF-\u03baB p65 signaling pathway and MMP9. Int Immunopharmacol 133:112082","journal-title":"Int Immunopharmacol"},{"issue":"1","key":"1874_CR23","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1186\/s12906-024-04356-x","volume":"24","author":"G Ma","year":"2024","unstructured":"Ma G, Dong Q, Li F, Jin Z, Pi J, Wu W, Li J (2024a) Network pharmacology and in vivo evidence of the pharmacological mechanism of geniposide in the treatment of atherosclerosis. BMC Complement Med Ther 24(1):53","journal-title":"BMC Complement Med Ther"},{"issue":"4","key":"1874_CR24","doi-asserted-by":"publisher","first-page":"346","DOI":"10.1080\/01616412.2024.2321014","volume":"46","author":"Y Ma","year":"2024","unstructured":"Ma Y, Hu X, Shen S, Pan D (2024b) Geniposide ameliorates brain injury in mice with intracerebral hemorrhage by inhibiting NF-\u03baB signaling. Neurol Res 46(4):346\u2013355","journal-title":"Neurol Res"},{"issue":"4","key":"1874_CR25","first-page":"3177","volume":"38","author":"R Makkar","year":"2024","unstructured":"Makkar R, Sehgal A, Singh S, Sharma N, Rawat R, Gulati M, Vargas-De-La-Cruz C, Ali N, Chitme HR, Behl T (2024) Investigating the anti-arthritic potential of Gallic acid from Tecoma stans leaves via phytosome based formulation and examining physical, hematological effects, and molecular dynamics simulations. J Biol Regul Homeost Agents 38(4):3177\u20133187","journal-title":"J Biol Regul Homeost Agents"},{"key":"1874_CR26","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.856457","volume":"13","author":"UAE Moure","year":"2022","unstructured":"Moure UAE, Tan T, Sha L, Lu X, Shao Z, Yang G, Wang Y, Cui H (2022) Advances in the immune regulatory role of non-coding RNAs (miRNAs and lncRNAs) in insect-pathogen interactions. Front Immunol 13:856457","journal-title":"Front Immunol"},{"issue":"1","key":"1874_CR27","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1007\/s10787-024-01612-x","volume":"33","author":"MM Nazir","year":"2024","unstructured":"Nazir MM, Farzeen I, Fasial S, Ashraf A (2024) Berberine in rheumatoid arthritis: a comprehensive review and meta-analysis of its anti-inflammatory and immunomodulatory mechanisms in animal models. Inflammopharmacology 33(1):215\u2013229","journal-title":"Inflammopharmacology"},{"key":"1874_CR28","doi-asserted-by":"publisher","first-page":"e934475","DOI":"10.12659\/MSM.934475","volume":"27","author":"DV Parums","year":"2021","unstructured":"Parums DV (2021) Review articles, systematic reviews, meta-analysis, and the updated preferred reporting items for systematic reviews and meta-analyses (PRISMA) 2020 guidelines. Med Sci Monitor 27:e934475\u2013e934471","journal-title":"Med Sci Monitor"},{"issue":"17","key":"1874_CR29","doi-asserted-by":"publisher","first-page":"1298","DOI":"10.2174\/0113894501276093231206064243","volume":"24","author":"P Prajapati","year":"2023","unstructured":"Prajapati P, Doshi G (2023) An update on the emerging role of Wnt\/\u03b2-catenin, SYK, PI3K\/AKT, and GM-CSF signaling pathways in rheumatoid arthritis. Curr Drug Targets 24(17):1298\u20131316","journal-title":"Curr Drug Targets"},{"key":"1874_CR30","unstructured":"PRISMA, P. Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA), 2020. In."},{"key":"1874_CR31","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2021.113958","volume":"273","author":"D Ran","year":"2021","unstructured":"Ran D, Hong W, Yan W, Mengdie W (2021) Properties and molecular mechanisms underlying geniposide-mediated therapeutic effects in chronic inflammatory diseases. J Ethnopharmacol 273:113958","journal-title":"J Ethnopharmacol"},{"key":"1874_CR32","doi-asserted-by":"publisher","DOI":"10.1007\/s10787-025-01731-z","author":"U Saleem","year":"2025","unstructured":"Saleem U, Farrukh M, Saadullah M, Siddique R, Gul H, Ahmad A, Shaukat B, Shah MA (2025) Role of polyphenolics in the management of rheumatoid arthritis through intracellular signaling pathways: a mechanistic review. Inflammopharmacology. https:\/\/doi.org\/10.1007\/s10787-025-01731-z","journal-title":"Inflammopharmacology"},{"issue":"2","key":"1874_CR33","doi-asserted-by":"publisher","first-page":"298","DOI":"10.1016\/j.intimp.2014.04.004","volume":"20","author":"Q Shi","year":"2014","unstructured":"Shi Q, Cao J, Fang L, Zhao H, Liu Z, Ran J, Zheng X, Li X, Zhou Y, Ge D (2014) Geniposide suppresses LPS-induced nitric oxide, PGE2 and inflammatory cytokine by downregulating NF-\u03baB, MAPK and AP-1 signaling pathways in macrophages. Int Immunopharmacol 20(2):298\u2013306","journal-title":"Int Immunopharmacol"},{"key":"1874_CR34","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2020.117988","volume":"256","author":"M Sun","year":"2020","unstructured":"Sun M, Deng R, Wang Y, Wu H, Zhang Z, Bu Y, Zhang H (2020) Sphingosine kinase 1\/sphingosine 1-phosphate\/sphingosine 1-phosphate receptor 1 pathway: a novel target of geniposide to inhibit angiogenesis. Life Sci 256:117988","journal-title":"Life Sci"},{"issue":"1","key":"1874_CR35","doi-asserted-by":"publisher","first-page":"9247947","DOI":"10.1155\/2021\/9247947","volume":"2021","author":"Y Tu","year":"2021","unstructured":"Tu Y, Li L, Zhu L, Guo Y, Du S, Zhang Y, Wang Z, Zhang Y, Zhu M (2021) Geniposide attenuates hyperglycemia-induced oxidative stress and inflammation by activating the Nrf2 signaling pathway in experimental diabetic retinopathy. Oxid Med Cell Longev 2021(1):9247947","journal-title":"Oxid Med Cell Longev"},{"issue":"2","key":"1874_CR36","doi-asserted-by":"publisher","first-page":"1189","DOI":"10.1007\/s11030-024-10900-1","volume":"29","author":"Y Velmurugan","year":"2025","unstructured":"Velmurugan Y, Natarajan SR, Chakkarapani N, Jayaraman S, Madhukar H, Venkatachalam R (2025) In silico and in vitro studies for the identification of small molecular inhibitors from Euphorbia hirta Linn for rheumatoid arthritis: targeting TNF-\u03b1-mediated inflammation. Mol Divers 29(2):1189\u20131206","journal-title":"Mol Divers"},{"issue":"3","key":"1874_CR37","doi-asserted-by":"publisher","first-page":"152","DOI":"10.1007\/s12688-022-00525-3","volume":"21","author":"T Voigt","year":"2022","unstructured":"Voigt T, Bause L, Rath T, Braun S, Magnolo N, Metze D, Tsianakas A (2022) Rheumatoide Arthritis. Rheuma plus 21(3):152\u2013159","journal-title":"Rheuma plus"},{"issue":"4","key":"1874_CR38","doi-asserted-by":"publisher","first-page":"382","DOI":"10.3109\/02652048.2013.863396","volume":"31","author":"F Wang","year":"2014","unstructured":"Wang F, Cao J, Hao J, Liu K (2014) Pharmacokinetics, tissue distribution and relative bioavailability of geniposide-solid lipid nanoparticles following oral administration. J Microencapsul 31(4):382\u2013389","journal-title":"J Microencapsul"},{"issue":"4","key":"1874_CR39","doi-asserted-by":"publisher","first-page":"631","DOI":"10.1002\/ptr.5775","volume":"31","author":"R Wang","year":"2017","unstructured":"Wang R, Wu H, Chen J, Li SP, Dai L, Zhang ZR, Wang WY (2017) Antiinflammation effects and mechanisms study of geniposide on rats with collagen-induced arthritis. Phytother Res 31(4):631\u2013637","journal-title":"Phytother Res"},{"issue":"6","key":"1874_CR40","doi-asserted-by":"publisher","first-page":"516","DOI":"10.1002\/rcm.8056","volume":"32","author":"WY Wang","year":"2018","unstructured":"Wang WY, Wang W, Wu H, Li SP, Wang R, Dai L, Zhang ZR, Fu J, Deng R, Li F (2018) Microdialysis sampling combined with ultra-high-performance liquid chromatography\/tandem mass spectrometry for the determination of geniposide in dialysate of joint cavities in adjuvant arthritis rats. Rapid Commun Mass Spectrom 32(6):516\u2013522","journal-title":"Rapid Commun Mass Spectrom"},{"key":"1874_CR41","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2020.584176","volume":"11","author":"R-H Wang","year":"2020","unstructured":"Wang R-H, Dai X-J, Wu H, Wang M-D, Deng R, Wang Y, Bu Y-H, Sun M-H, Zhang H (2020) Anti-inflammatory effect of geniposide on regulating the functions of rheumatoid arthritis synovial fibroblasts via inhibiting sphingosine-1-phosphate receptors1\/3 coupling g\u03b1i\/g\u03b1s conversion. Front Pharmacol 11:584176","journal-title":"Front Pharmacol"},{"issue":"8","key":"1874_CR42","doi-asserted-by":"publisher","first-page":"4347","DOI":"10.1002\/ptr.7130","volume":"35","author":"Y Wang","year":"2021","unstructured":"Wang Y, Wu H, Deng R, Dai Xj, Bu Yh, Sun Mh, Zhang H, Wang Md, Wang Rh (2021) Geniposide downregulates the VEGF\/SphK1\/S1P pathway and alleviates angiogenesis in rheumatoid arthritis in vivo and in vitro. Phytother Res 35(8):4347\u20134362","journal-title":"Phytother Res"},{"issue":"5","key":"1874_CR43","doi-asserted-by":"publisher","first-page":"564","DOI":"10.1136\/ard-2023-224852","volume":"83","author":"G Wu","year":"2024","unstructured":"Wu G, Cao B, Zhai H, Liu B, Huang Y, Chen X, Ling H, Ling S, Jin S, Yang X (2024) EPO promotes the progression of rheumatoid arthritis by inducing desialylation via increasing the expression of neuraminidase 3. Ann Rheum Dis 83(5):564\u2013575","journal-title":"Ann Rheum Dis"},{"key":"1874_CR44","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1007\/s10753-020-01338-2","volume":"44","author":"Z Xie","year":"2021","unstructured":"Xie Z, Hou H, Luo D, An R, Zhao Y, Qiu C (2021) ROS-dependent lipid peroxidation and reliant antioxidant ferroptosis-suppressor-protein 1 in rheumatoid arthritis: a covert clue for potential therapy. Inflammation 44:35\u201347","journal-title":"Inflammation"},{"issue":"2","key":"1874_CR45","doi-asserted-by":"publisher","first-page":"277","DOI":"10.4314\/tjpr.v17i2.12","volume":"17","author":"S Xu","year":"2018","unstructured":"Xu S, Peng H, Wang N, Zhao M (2018) Inhibition of TNF-\u03b1 and IL-1 by compounds from selected plants for rheumatoid arthritis therapy: in vivo and in silico studies. Trop J Pharm Res 17(2):277\u2013285","journal-title":"Trop J Pharm Res"},{"key":"1874_CR46","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2022.106549","volume":"186","author":"J Yang","year":"2022","unstructured":"Yang J, Li Z, Wang L, Yun X, Zeng Y, Ng JP, Lo H, Wang Y, Zhang K, Law BYK (2022) The role of non-coding RNAs (miRNA and lncRNA) in the clinical management of rheumatoid arthritis. Pharmacol Res 186:106549","journal-title":"Pharmacol Res"},{"issue":"2","key":"1874_CR47","doi-asserted-by":"publisher","first-page":"118","DOI":"10.1016\/j.tips.2023.12.001","volume":"45","author":"X Yang","year":"2024","unstructured":"Yang X, Zhang W, Wang L, Zhao Y, Wei W (2024) Metabolite-sensing GPCRs in rheumatoid arthritis. Trends Pharmacol Sci 45(2):118\u2013133","journal-title":"Trends Pharmacol Sci"},{"issue":"9","key":"1874_CR48","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0309833","volume":"19","author":"J-B Yin","year":"2024","unstructured":"Yin J-B, Wang Y-X, Fan S-S, Shang W-B, Zhu Y-S, Peng X-R, Zou C, Zhang X (2024) Geniposide ameliorates bleomycin-induced pulmonary fibrosis in mice by inhibiting TGF-\u03b2\/Smad and p38MAPK signaling pathways. PLoS ONE 19(9):e0309833","journal-title":"PLoS ONE"},{"key":"1874_CR49","doi-asserted-by":"crossref","unstructured":"Yuandani, Jantan I, Salim E, Septama AW, Rullah K, Nainu F, Fasihi Mohd Aluwi MF, Emran TB, Roney M, Khairunnisa NA (2024). Mechanistic insights into anti\u2010inflammatory and immunosuppressive effects of plant secondary metabolites and their therapeutic potential for rheumatoid arthritis. Phytother Res 38(6), 2931\u20132961.","DOI":"10.1002\/ptr.8147"},{"issue":"9","key":"1874_CR50","doi-asserted-by":"publisher","first-page":"3769","DOI":"10.1021\/acs.jproteome.0c00300","volume":"19","author":"X Zhan","year":"2020","unstructured":"Zhan X, Wu H, Wu H (2020) Joint synovial fluid metabolomics method to decipher the metabolic mechanisms of adjuvant arthritis and geniposide intervention. J Proteome Res 19(9):3769\u20133778","journal-title":"J Proteome Res"},{"issue":"8","key":"1874_CR51","doi-asserted-by":"publisher","first-page":"1249","DOI":"10.1002\/ptr.5847","volume":"31","author":"ZR Zhang","year":"2017","unstructured":"Zhang ZR, Wu H, Wang R, Li SP, Dai L, Wang WY (2017) Immune tolerance effect in mesenteric lymph node lymphocytes of geniposide on adjuvant arthritis rats. Phytother Res 31(8):1249\u20131256","journal-title":"Phytother Res"},{"key":"1874_CR52","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2020.113402","volume":"266","author":"X Zhao","year":"2021","unstructured":"Zhao X, Jiang S, Dong Q, Dang J, Liu Z, Han H, Tao Y, Yue H (2021) Anti-rheumatoid arthritis effects of iridoid glucosides from Lamiophlomis rotata (Benth.) kudo on adjuvant-induced arthritis in rats by OPG\/RANKL\/NF-\u03baB signaling pathways. J Ethnopharmacol 266:113402","journal-title":"J Ethnopharmacol"}],"container-title":["Inflammopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10787-025-01874-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10787-025-01874-z\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10787-025-01874-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,8]],"date-time":"2025-09-08T16:47:09Z","timestamp":1757350029000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10787-025-01874-z"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8]]},"references-count":52,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2025,8]]}},"alternative-id":["1874"],"URL":"https:\/\/doi.org\/10.1007\/s10787-025-01874-z","relation":{},"ISSN":["0925-4692","1568-5608"],"issn-type":[{"value":"0925-4692","type":"print"},{"value":"1568-5608","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,8]]},"assertion":[{"value":"20 June 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 July 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 August 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"There is no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"N\/A.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}}]}}