{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T13:11:21Z","timestamp":1788613881033,"version":"build-2803163510"},"reference-count":55,"publisher":"Springer Science and Business Media LLC","issue":"8","license":[{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2025,8,7]],"date-time":"2025-08-07T00:00:00Z","timestamp":1754524800000},"content-version":"vor","delay-in-days":6,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100002386","name":"Cairo University","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100002386","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Inflammopharmacol"],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n          <jats:p>Gastric ulcer is a common gastrointestinal condition. Arabincoside B (AR-B), a pregnane glycoside isolated from the aerial parts of <jats:italic>Caralluma arabica<\/jats:italic>, shows multiple pharmacological effects. This study aimed to investigate the gastroprotective therapeutic effects of AR-B in ethanol-induced gastric injury in rats. Rats were divided as follows: Group I (NC): received 1 mL\/day of normal saline; Group II (PC): received distilled water then 95% ethanol (1 mL per rat) after 1 h; Group III (FAM): received oral famotidine (20 mg\/kg); Groups IV and V (AR-B groups): received 25 and 50 mg\/kg of AR-B, respectively. Treatments (FAM or AR-B) were administered 1 h prior to ethanol. The rats were killed after 1 h after ethanol administration. Gross inspections as well as histopathological assessment of stomach tissues of untreated ethanol-only treated rats revealed major alterations as compared to those of normal rats. Pretreatment with AR-B showed enhancement in the gross and histological alterations. Moreover, AR-B at the dose of (50\u00a0mg\/kg) possessed superior anti-inflammatory and antioxidant effects. This was confirmed by a significant lowering of the serum IL-6 and TNF-\u03b1 levels, decreasing p-NF-\u03baB gastric expression, decreasing MDA, and increasing GSH gastric levels. Furthermore, AR-B caused a significant increase in TFF-2 and MUC-6 stomach tissue expression, preserving the gastric mucosa. In addition, gastric expression of substance P and NK-1R was decreased, which participated in the reduction of inflammation. The current research highlights the gastroprotective impact of AR-B especially at a dose of (50\u00a0mg\/kg), suggesting its future role in preventing recurrence in peptic ulcer patients.<\/jats:p>","DOI":"10.1007\/s10787-025-01885-w","type":"journal-article","created":{"date-parts":[[2025,8,7]],"date-time":"2025-08-07T16:19:10Z","timestamp":1754583550000},"page":"4859-4869","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Gastroprotective effect of Arabincoside B isolated from Caralluma arabica against ethanol-induced gastric injury via modulating oxidative stress\/SP\/NK-1R\/NF-\u03baB loop"],"prefix":"10.1007","volume":"33","author":[{"given":"Dalia E.","family":"Ali","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Othman S. S.","family":"Al-Hawshabi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah A. Abd","family":"El-Aal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eman","family":"Sheta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3467-5172","authenticated-orcid":false,"given":"Sherihan Salaheldin Abdelhamid","family":"Ibrahim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amira A.","family":"El-Gazar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0617-1420","authenticated-orcid":false,"given":"Essam","family":"Abdel-Sattar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ghada M.","family":"Ragab","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,8,7]]},"reference":[{"key":"1885_CR1","doi-asserted-by":"publisher","first-page":"990","DOI":"10.3389\/fphar.2018.00990","volume":"9","author":"E Abdel-Sattar","year":"2018","unstructured":"Abdel-Sattar E, Mehanna ET, El-Ghaiesh SH, Mohammad HM, Elgendy HA, Zaitone SA (2018) Pharmacological action of a pregnane glycoside, russelioside B, in dietary obese rats: impact on weight gain and energy expenditure. Front Pharmacol 9:990","journal-title":"Front Pharmacol"},{"key":"1885_CR2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tet.2022.132858","volume":"119","author":"EA Abdel-Sattar","year":"2022","unstructured":"Abdel-Sattar EA, Al-Hawshabi OS, Shalabi AA, El Halawany AM, Meselhy MR (2022) Arabincosides AD, pregnane glycosides isolated from Caralluma arabica. Tetrahedron 119:132858. https:\/\/doi.org\/10.1016\/j.tet.2022.132858","journal-title":"Tetrahedron"},{"issue":"10","key":"1885_CR3","doi-asserted-by":"publisher","first-page":"1351","DOI":"10.1111\/jphp.12265","volume":"66","author":"M Adnan","year":"2014","unstructured":"Adnan M, Jan S, Mussarat S, Tariq A, Begum S, Afroz A, Shinwari ZK (2014) A review on ethnobotany, phytochemistry and pharmacology of plant genus c aralluma r. br. J Pharm Pharmacol 66(10):1351\u20131368. https:\/\/doi.org\/10.1111\/jphp.12265","journal-title":"J Pharm Pharmacol"},{"issue":"5","key":"1885_CR4","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0064751","volume":"8","author":"R Al Batran","year":"2013","unstructured":"Al Batran R, Al-Bayaty F, Jamil Al-Obaidi MM, Abdualkader AM, Hadi HA, Ali HM, Abdulla MA (2013) In vivo antioxidant and antiulcer activity of Parkia speciosa ethanolic leaf extract against ethanol-induced gastric ulcer in rats. PLoS ONE 8(5):e64751. https:\/\/doi.org\/10.1371\/journal.pone.0064751","journal-title":"PLoS ONE"},{"issue":"1","key":"1885_CR5","doi-asserted-by":"publisher","first-page":"738493","DOI":"10.1155\/2014\/738493","volume":"2014","author":"N Albaser","year":"2014","unstructured":"Albaser N, Ghanem N, Shehab M, Al-Adhal A, Amood Al-Kamarany M (2014) Investigation of pharmacological activity of Caralluma penicillata: anti-inflammatory properties and gastritis protection against indomethacin in adult guinea pigs. Int Sch Res Notices 2014(1):738493. https:\/\/doi.org\/10.1155\/2014\/738493","journal-title":"Int Sch Res Notices"},{"issue":"1","key":"1885_CR6","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1006\/taap.1994.1173","volume":"128","author":"MM Alharbi","year":"1994","unstructured":"Alharbi MM, Qureshi S, Raza M, Ahmed MM, Afzal M, Shah AH (1994) Evaluation of Caralluma tuberculata pretreatment for the protection of rat gastric mucosa against toxic damage. Toxicol Appl Pharmacol 128(1):1\u20138. https:\/\/doi.org\/10.1006\/taap.1994.1173","journal-title":"Toxicol Appl Pharmacol"},{"issue":"1","key":"1885_CR7","doi-asserted-by":"publisher","first-page":"465","DOI":"10.1007\/s10787-022-01112-w","volume":"31","author":"DE Ali","year":"2023","unstructured":"Ali DE, Abd El-Aziz MM, Ibrahim SSA, Sheta E, Abdel-Sattar E (2023) Gastroprotective and anti-Helicobacter pylori potentials of essential oils from the oleoresins of Araucaria bidwillii and Araucaria heterophylla. Inflammopharmacology 31(1):465\u2013483. https:\/\/doi.org\/10.1007\/s10787-022-01112-w","journal-title":"Inflammopharmacology"},{"issue":"1","key":"1885_CR8","doi-asserted-by":"publisher","first-page":"282","DOI":"10.1186\/s12917-024-04128-2","volume":"20","author":"MM Ali","year":"2024","unstructured":"Ali MM, Al-Mokaddem AK, Abdel-Sattar E, El-Shiekh RA, Farag MM, Aljuaydi SH, Shaheed IB (2024a) Enhanced wound healing potential of arabincoside B isolated from Caralluma Arabica in rat model; a possible dressing in veterinary practice. BMC Vet Res 20(1):282. https:\/\/doi.org\/10.1186\/s12917-024-04128-2","journal-title":"BMC Vet Res"},{"key":"1885_CR9","doi-asserted-by":"publisher","first-page":"117115","DOI":"10.1016\/j.jep.2023.117115","volume":"319","author":"NB Ali","year":"2024","unstructured":"Ali NB, Ibrahim SSA, Alsherbiny MA, Sheta E, El-Shiekh RA, Ashour RM, El-Gazar AA, Ragab GM, El-Gayed SH, Li CG (2024b) Gastroprotective potential of red onion (Allium cepa L.) peel in ethanol-induced gastric injury in rats: Involvement of Nrf2\/HO-1 and HMGB-1\/NF-\u03baB trajectories. J Ethnopharmacol 319:117115. https:\/\/doi.org\/10.1016\/j.jep.2023.117115","journal-title":"J Ethnopharmacol"},{"key":"1885_CR10","doi-asserted-by":"publisher","first-page":"554","DOI":"10.1016\/j.biopha.2018.12.002","volume":"110","author":"RS Aziz","year":"2019","unstructured":"Aziz RS, Siddiqua A, Shahzad M, Shabbir A, Naseem N (2019) Oxyresveratrol ameliorates ethanol-induced gastric ulcer via downregulation of IL-6, TNF-\u03b1, NF-\u0138B, and COX-2 levels, and upregulation of TFF-2 levels. Biomed Pharmacother 110:554\u2013560. https:\/\/doi.org\/10.1016\/j.biopha.2018.12.002","journal-title":"Biomed Pharmacother"},{"key":"1885_CR11","doi-asserted-by":"publisher","first-page":"370","DOI":"10.1016\/j.lfs.2018.08.035","volume":"209","author":"KRM Barboza","year":"2018","unstructured":"Barboza KRM, Coco LZ, Alves GM, Peters B, Vasquez EC, Pereira TMC, Meyrelles SS, Campagnaro BP (2018) Gastroprotective effect of oral kefir on indomethacin-induced acute gastric lesions in mice: Impact on oxidative stress. Life Sci 209:370\u2013376. https:\/\/doi.org\/10.1016\/j.lfs.2018.08.035","journal-title":"Life Sci"},{"issue":"3","key":"1885_CR12","doi-asserted-by":"publisher","first-page":"385","DOI":"10.1038\/sj.bjp.0706198","volume":"145","author":"C Bardelli","year":"2005","unstructured":"Bardelli C, Gunella G, Varsaldi F, Balbo P, Del Boca E, Bernardone IS, Amoruso A, Brunelleschi S (2005) Expression of functional NK1 receptors in human alveolar macrophages: superoxide anion production, cytokine release and involvement of NF-\u03baB pathway. Brit J Pharmacol 145(3):385\u2013396. https:\/\/doi.org\/10.1038\/sj.bjp.0706198","journal-title":"Brit J Pharmacol"},{"issue":"6","key":"1885_CR13","doi-asserted-by":"publisher","first-page":"916","DOI":"10.1002\/cbdv.200800159","volume":"6","author":"FY Chen","year":"2009","unstructured":"Chen FY, Ye YP, Sun HX, Li XY, Shi H (2009) Stemucronatoside L, a pregnane glycoside from the roots of Stephanotis mucronata, inhibits Th1\/Th2 immune responses in vitro. Chem Biodivers 6(6):916\u2013923. https:\/\/doi.org\/10.1002\/cbdv.200800159","journal-title":"Chem Biodivers"},{"key":"1885_CR55","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1016\/j.cbi.2016.10.021","volume":"260","author":"P Chen","year":"2016","unstructured":"Chen P et al (2016) Gastroprotective effects of Kangfuxin-against ethanol-induced gastric ulcer via attenuating oxidative stress and ER stress in mice. Chem Biol Interact 260:75\u201383. https:\/\/doi.org\/10.1016\/j.cbi.2016.10.021","journal-title":"Chem Biol Interact"},{"issue":"39","key":"1885_CR14","doi-asserted-by":"publisher","first-page":"6529","DOI":"10.3748\/wjg.v19.i39.6529","volume":"19","author":"M Cicala","year":"2013","unstructured":"Cicala M, Emerenziani S, Guarino MPL, Ribolsi M (2013) Proton pump inhibitor resistance, the real challenge in gastro-esophageal reflux disease. World J Gastroenterol 19(39):6529. https:\/\/doi.org\/10.3748\/wjg.v19.i39.6529","journal-title":"World J Gastroenterol"},{"issue":"19","key":"1885_CR15","doi-asserted-by":"publisher","first-page":"7409","DOI":"10.1073\/pnas.0308489101","volume":"101","author":"M Clyne","year":"2004","unstructured":"Clyne M, Dillon P, Daly S, O\u2019Kennedy R, May FE, Westley BR, Drumm B (2004) Helicobacter pylori interacts with the human single-domain trefoil protein TFF1. Proc Natl Acad Sci 101(19):7409\u20137414. https:\/\/doi.org\/10.1073\/pnas.0308489101","journal-title":"Proc Natl Acad Sci"},{"issue":"1","key":"1885_CR16","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1111\/j.1749-6632.2010.05826.x","volume":"1217","author":"SD Douglas","year":"2011","unstructured":"Douglas SD, Leeman SE (2011) Neurokinin-1 receptor: functional significance in the immune system in reference to selected infections and inflammation. Ann N Y Acad Sci 1217(1):83\u201395. https:\/\/doi.org\/10.1111\/j.1749-6632.2010.05826.x","journal-title":"Ann N Y Acad Sci"},{"issue":"2","key":"1885_CR17","doi-asserted-by":"publisher","first-page":"108","DOI":"10.1089\/jmf.2010.1555","volume":"15","author":"HC Dutt","year":"2012","unstructured":"Dutt HC, Singh S, Avula B, Khan IA, Bedi YS (2012) Pharmacological review of Caralluma R. Br. with special reference to appetite suppression and anti-obesity. J Med Food 15(2):108\u2013119. https:\/\/doi.org\/10.1089\/jmf.2010.1555","journal-title":"J Med Food"},{"key":"1885_CR18","doi-asserted-by":"publisher","DOI":"10.1016\/j.abb.2024.110103","volume":"759","author":"EM Elbaz","year":"2024","unstructured":"Elbaz EM, Rahman AAA, El-Gazar AA, Ali BM (2024) Protective effect of dimethyl fumarate against ethanol-provoked gastric ulcers in rats via regulation of HMGB1\/TLR4\/NF-\u03baB, and PPAR\u03b3\/SIRT1\/Nrf2 pathways: Involvement of miR-34a-5p. Arch Biochem Biophys 759:110103. https:\/\/doi.org\/10.1016\/j.abb.2024.110103","journal-title":"Arch Biochem Biophys"},{"key":"1885_CR19","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2021.113779","volume":"270","author":"RA El-Shiekh","year":"2021","unstructured":"El-Shiekh RA, El-Mekkawy S, Mouneir SM, Hassan A, Abdel-Sattar E (2021) Therapeutic potential of russelioside B as anti-arthritic agent in Freund\u2019s adjuvant-induced arthritis in rats. J Ethnopharmacol 270:113779","journal-title":"J Ethnopharmacol"},{"issue":"3","key":"1885_CR20","doi-asserted-by":"publisher","first-page":"1437","DOI":"10.1007\/s10787-023-01159-3","volume":"31","author":"RA El-Shiekh","year":"2023","unstructured":"El-Shiekh RA, Nabil G, Shokry AA, Ahmed YH, Al-Hawshabi OS, Abdel-Sattar E (2023) Arabincoside B isolated from Caralluma arabica as a potential anti-pneumonitis in LPS mice model. Inflammopharmacology 31(3):1437\u20131447. https:\/\/doi.org\/10.1007\/s10787-023-01159-3","journal-title":"Inflammopharmacology"},{"key":"1885_CR21","doi-asserted-by":"publisher","first-page":"984","DOI":"10.1007\/s43440-019-00049-2","volume":"72","author":"E Eraslan","year":"2020","unstructured":"Eraslan E, Tanyeli A, G\u00fcler MC, Kurt N, Yetim Z (2020) Agomelatine prevents indomethacin-induced gastric ulcer in rats. Pharmacol Rep 72:984\u2013991. https:\/\/doi.org\/10.1007\/s43440-019-00049-2","journal-title":"Pharmacol Rep"},{"issue":"2","key":"1885_CR22","doi-asserted-by":"publisher","first-page":"405","DOI":"10.1016\/j.asjsur.2019.07.001","volume":"43","author":"G Ercan","year":"2020","unstructured":"Ercan G, Tartar RI, Solmaz A, Gulcicek OB, Karagulle OO, Meric S, Cayoren H, Kusaslan R, Kemik A, Kayali DG (2020) Potent therapeutic effects of ruscogenin on gastric ulcer established by acetic acid. Asian J Surg 43(2):405\u2013416. https:\/\/doi.org\/10.1016\/j.asjsur.2019.07.001","journal-title":"Asian J Surg"},{"key":"1885_CR23","first-page":"113","volume":"10","author":"M Fornai","year":"2011","unstructured":"Fornai M, Antonioli L, Colucci R, Tuccori M, Blandizzi C (2011) Pathophysiology of gastric ulcer development and healing: molecular mechanisms and novel therapeutic options. Peptic Ulcer Dis 10:113\u2013142","journal-title":"Peptic Ulcer Dis"},{"key":"1885_CR24","doi-asserted-by":"publisher","first-page":"798421","DOI":"10.3389\/fphar.2021.798421","volume":"12","author":"S Fu","year":"2021","unstructured":"Fu S, Chen J, Zhang C, Shi J, Nie X, Hu Y, Fu C, Li X, Zhang J (2021) Gastroprotective effects of Periplaneta americana L. extract against ethanol-induced gastric ulcer in mice by suppressing apoptosis-related pathways. Front Pharmacol 12:798421. https:\/\/doi.org\/10.3389\/fphar.2021.798421","journal-title":"Front Pharmacol"},{"issue":"4","key":"1885_CR25","doi-asserted-by":"publisher","first-page":"222","DOI":"10.4103\/0257-7941.188182","volume":"35","author":"S Garg","year":"2016","unstructured":"Garg S, Srivastava S, Singh K, Sharma A, Garg K (2016) Ulcer healing potential of ethanolic extract of Caralluma attenuata on experimental diabetic rats. Ancient Sci Life 35(4):222\u2013226. https:\/\/doi.org\/10.4103\/0257-7941.188182","journal-title":"Ancient Sci Life"},{"issue":"6","key":"1885_CR26","doi-asserted-by":"publisher","first-page":"763","DOI":"10.3390\/nu10060763","volume":"10","author":"O Guzm\u00e1n-G\u00f3mez","year":"2018","unstructured":"Guzm\u00e1n-G\u00f3mez O, Garc\u00eda-Rodr\u00edguez RV, Quevedo-Corona L, P\u00e9rez-Past\u00e9n-Borja R, Rivero-Ram\u00edrez NL, R\u00edos-Castro E, P\u00e9rez-Guti\u00e9rrez S, P\u00e9rez-Ramos J, Chamorro-Cevallos GA (2018) Amelioration of ethanol-induced gastric ulcers in rats pretreated with phycobiliproteins of Arthrospira (Spirulina) Maxima. Nutrients 10(6):763. https:\/\/doi.org\/10.3390\/nu10060763","journal-title":"Nutrients"},{"issue":"3","key":"1885_CR27","doi-asserted-by":"publisher","first-page":"806","DOI":"10.3892\/ijo.2015.3090","volume":"47","author":"W Hoffmann","year":"2015","unstructured":"Hoffmann W (2015) TFF2, a MUC6-binding lectin stabilizing the gastric mucus barrier and more. Int J Oncol 47(3):806\u2013816. https:\/\/doi.org\/10.3892\/ijo.2015.3090","journal-title":"Int J Oncol"},{"key":"1885_CR28","doi-asserted-by":"publisher","first-page":"3707","DOI":"10.2147\/DDDT.S453787","volume":"17","author":"IAA Ibrahim","year":"2023","unstructured":"Ibrahim IAA, Abdulla MA, Hajrezaei M, Bader A, Shahzad N, Al-Ghamdi SS, Gushash AS, Hasanpourghadi M (2023) The gastroprotective effects of hydroalcoholic extract of monolluma quadrangula against ethanol-induced gastric mucosal injuries in Sprague Dawley rats [retraction]. Drug des Dev Therapy 17:3707\u20133708. https:\/\/doi.org\/10.2147\/DDDT.S453787","journal-title":"Drug des Dev Therapy"},{"key":"1885_CR29","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2024.112440","volume":"137","author":"SSA Ibrahim","year":"2024","unstructured":"Ibrahim SSA, Bassam SM, El-Hawary S, Sheta E, Masoud IM, El-Zahaby SA, Al-Mahallawi AM, Hammad GO (2024) The gastroprotective effect of Yucca filamentosa standardized crude leaves extract versus its nano-cubosomal formulation in ethanol-induced gastric injury. Int Immunopharmacol 137:112440. https:\/\/doi.org\/10.1016\/j.intimp.2024.112440","journal-title":"Int Immunopharmacol"},{"issue":"2","key":"1885_CR30","doi-asserted-by":"publisher","DOI":"10.1002\/jbt.22961","volume":"36","author":"N Ilhan","year":"2022","unstructured":"Ilhan N, Bektas I, Susam S, Ozercan IH (2022) Protective effects of rosmarinic acid against azoxymethane-induced colorectal cancer in rats. J Biochem Mol Toxicol 36(2):e22961. https:\/\/doi.org\/10.1002\/jbt.22961","journal-title":"J Biochem Mol Toxicol"},{"issue":"2","key":"1885_CR31","doi-asserted-by":"publisher","first-page":"182","DOI":"10.5056\/jnm18001","volume":"24","author":"Y Kinoshita","year":"2018","unstructured":"Kinoshita Y, Ishimura N, Ishihara S (2018) Advantages and disadvantages of long-term proton pump inhibitor use. J Neurogastroenterol Motil 24(2):182. https:\/\/doi.org\/10.5056\/jnm18001","journal-title":"J Neurogastroenterol Motil"},{"issue":"3","key":"1885_CR32","doi-asserted-by":"publisher","first-page":"1393","DOI":"10.1124\/jpet.105.088013","volume":"314","author":"H-W Koon","year":"2005","unstructured":"Koon H-W, Zhao D, Zhan Y, Simeonidis S, Moyer MP, Pothoulakis C (2005) Substance P-stimulated interleukin-8 expression in human colonic epithelial cells involves protein kinase C\u03b4 activation. J Pharmacol Exp Ther 314(3):1393\u20131400. https:\/\/doi.org\/10.1124\/jpet.105.088013","journal-title":"J Pharmacol Exp Ther"},{"issue":"4","key":"1885_CR33","doi-asserted-by":"publisher","first-page":"S1146","DOI":"10.22377\/ajp.v12i04.2903","volume":"12","author":"S Malladi","year":"2018","unstructured":"Malladi S, Ratnakaram VN, Babu KS, Sreenivasulu M (2018) Pharmacological review of Caralluma r. br: a potential herbal genus. Asian J Pharm 12(4):S1146. https:\/\/doi.org\/10.22377\/ajp.v12i04.2903","journal-title":"Asian J Pharm"},{"issue":"3","key":"1885_CR34","doi-asserted-by":"publisher","first-page":"817","DOI":"10.1016\/0306-4522(88)90038-3","volume":"25","author":"P Mantyh","year":"1988","unstructured":"Mantyh P, Mantyh C, Gates T, Vigna S, Maggio J (1988) Receptor binding sites for substance P and substance K in the canine gastrointestinal tract and their possible role in inflammatory bowel disease. Neuroscience 25(3):817\u2013837. https:\/\/doi.org\/10.1016\/0306-4522(88)90038-3","journal-title":"Neuroscience"},{"issue":"3","key":"1885_CR35","doi-asserted-by":"publisher","first-page":"627","DOI":"10.1016\/0196-9781(89)90154-X","volume":"10","author":"PW Mantyh","year":"1989","unstructured":"Mantyh PW, Catton MD, Boehmer CG, Welton ML, Passaro EP, Maggio JE, Vigna SR (1989) Receptors for sensory neuropeptides in human inflammatory diseases: implications for the effector role of sensory neurons. Peptides 10(3):627\u2013645. https:\/\/doi.org\/10.1016\/0196-9781(89)90154-X","journal-title":"Peptides"},{"key":"1885_CR36","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s12906-019-2760-9","volume":"19","author":"AM Mousa","year":"2019","unstructured":"Mousa AM, El-Sammad NM, Hassan SK, Madboli AENA, Hashim AN, Moustafa ES, Bakry SM, Elsayed EA (2019) Antiulcerogenic effect of Cuphea ignea extract against ethanol-induced gastric ulcer in rats. BMC Complement Altern Med 19:1\u201313. https:\/\/doi.org\/10.1186\/s12906-019-2760-9","journal-title":"BMC Complement Altern Med"},{"issue":"11","key":"1885_CR37","doi-asserted-by":"publisher","first-page":"567","DOI":"10.1016\/j.jcma.2014.07.006","volume":"77","author":"Y-C Peng","year":"2014","unstructured":"Peng Y-C, Huang L-R, Shyu C-L, Cheng C-C, Ho S-P (2014) Interaction of omeprazole and Helicobacter pylori-induced nuclear factor-\u03baB activation and mediators in gastric epithelial cells. J Chin Med Assoc 77(11):567\u2013572. https:\/\/doi.org\/10.1016\/j.jcma.2014.07.006","journal-title":"J Chin Med Assoc"},{"issue":"2","key":"1885_CR38","doi-asserted-by":"publisher","first-page":"13","DOI":"10.21767\/2577-0586.100043","volume":"2","author":"N Qayyum","year":"2018","unstructured":"Qayyum N, Rani H, Mir KB, Khan AQ (2018) Caralluma pharmacological attributes. J Food 2(2):13. https:\/\/doi.org\/10.21767\/2577-0586.100043","journal-title":"J Food"},{"key":"1885_CR39","doi-asserted-by":"publisher","first-page":"148","DOI":"10.5138\/09750185.2257","volume":"10","author":"MA Raees","year":"2018","unstructured":"Raees MA (2018) A phytopharmacological review on an Arabian medicinal plant: Caralluma flava NE Br. Int J Phytomed 10:148\u2013152. https:\/\/doi.org\/10.5138\/09750185.2257","journal-title":"Int J Phytomed"},{"key":"1885_CR40","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2021.622815","volume":"12","author":"M Raish","year":"2021","unstructured":"Raish M, Shahid M, Bin Jardan YA, Ansari MA, Alkharfy KM, Ahad A, Abdelrahman IA, Ahmad A, Al-Jenoobi FI (2021) Gastroprotective effect of sinapic acid on ethanol-induced gastric ulcers in rats: involvement of Nrf2\/HO-1 and NF-\u03baB signaling and antiapoptotic role. Front Pharmacol 12:622815. https:\/\/doi.org\/10.3389\/fphar.2021.622815","journal-title":"Front Pharmacol"},{"issue":"3","key":"1885_CR41","doi-asserted-by":"publisher","first-page":"433","DOI":"10.1016\/0016-5085(79)90002-7","volume":"77","author":"A Robert","year":"1979","unstructured":"Robert A, Nezamis JE, Lancaster C, Hanchar AJ (1979) Cytoprotection by prostaglandins in rats: Prevention of gastric necrosis produced by alcohol, HCl, NaOH, hypertonic NaCl, and thermal injury. Gastroenterology 77(3):433\u2013443. https:\/\/doi.org\/10.1016\/0016-5085(79)90002-7","journal-title":"Gastroenterology"},{"issue":"2","key":"1885_CR42","doi-asserted-by":"publisher","first-page":"332","DOI":"10.3390\/plants10020332","volume":"10","author":"M-S Shin","year":"2021","unstructured":"Shin M-S, Lee J, Lee JW, Park SH, Lee IK, Choi JA, Lee JS, Kang KS (2021) Anti-inflammatory effect of Artemisia argyi on ethanol-induced gastric ulcer: analytical, in vitro and in vivo studies for the identification of action mechanism and active compounds. Plants 10(2):332. https:\/\/doi.org\/10.3390\/plants10020332","journal-title":"Plants"},{"issue":"2","key":"1885_CR43","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1002\/ame2.12060","volume":"2","author":"S Sim\u00f5es","year":"2019","unstructured":"Sim\u00f5es S, Lopes R, Campos MCD, Marruz MJ, da Cruz MEM, Corvo L (2019) Animal models of acute gastric mucosal injury: macroscopic and microscopic evaluation. AMEM 2(2):121\u2013126. https:\/\/doi.org\/10.1002\/ame2.12060","journal-title":"AMEM"},{"issue":"1","key":"1885_CR44","doi-asserted-by":"publisher","first-page":"273","DOI":"10.1016\/j.jep.2012.02.030","volume":"141","author":"MME Taha","year":"2012","unstructured":"Taha MME, Salga MS, Ali HM, Abdulla MA, Abdelwahab SI, Hadi AHA (2012) Gastroprotective activities of Turnera diffusa Willd. ex Schult. revisited: Role of arbutin. J Ethnopharmacol 141(1):273\u2013281. https:\/\/doi.org\/10.1016\/j.jep.2012.02.030","journal-title":"J Ethnopharmacol"},{"issue":"6","key":"1885_CR45","doi-asserted-by":"publisher","first-page":"1296","DOI":"10.1152\/ajpgi.2001.280.6.G1296","volume":"280","author":"S Takahashi","year":"2001","unstructured":"Takahashi S, Fujita T, Yamamoto A (2001) Role of nuclear factor-\u03baB in gastric ulcer healing in rats. Am J Physiol-Gastrointest Liver Physiol 280(6):1296\u20131304. https:\/\/doi.org\/10.1152\/ajpgi.2001.280.6.G1296","journal-title":"Am J Physiol-Gastrointest Liver Physiol"},{"issue":"14","key":"1885_CR46","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1016\/S0975-3575(10)80069-0","volume":"2","author":"DA Tambe","year":"2010","unstructured":"Tambe DA, Chaudhari TB, Chaudhari SR (2010) Phyto-pharmacology of Caralluma adscendens roxb: a review. Pharmacognosy Journal 2(14):33\u201338. https:\/\/doi.org\/10.1016\/S0975-3575(10)80069-0","journal-title":"Pharmacognosy Journal"},{"issue":"2","key":"1885_CR47","doi-asserted-by":"publisher","first-page":"100728","DOI":"10.1016\/j.cpsurg.2019.100728","volume":"57","author":"A Wang","year":"2020","unstructured":"Wang A, Yerxa J, Agarwal S, Turner MC, Schroder V, Youngwirth LM, Lagoo-Deenadayalan S, Pappas TN (2020) Surgical management of peptic ulcer disease. Curr Probl Surg 57(2):100728\u2013100728. https:\/\/doi.org\/10.1016\/j.cpsurg.2019.100728","journal-title":"Curr Probl Surg"},{"issue":"24","key":"1885_CR48","doi-asserted-by":"publisher","first-page":"2658","DOI":"10.5897\/JMPR09.412","volume":"4","author":"S Wasman","year":"2010","unstructured":"Wasman S, Mahmood A, Salehhuddin H, Zahra A, Salmah I (2010) Cytoprotective activities of Polygonum minus aqueous leaf extract on ethanol-induced gastric ulcer in rats. J Med Plants Res 4(24):2658\u20132665. https:\/\/doi.org\/10.5897\/JMPR09.412","journal-title":"J Med Plants Res"},{"issue":"3","key":"1885_CR49","doi-asserted-by":"publisher","first-page":"228","DOI":"10.1159\/000484980","volume":"97","author":"Y Xu","year":"2018","unstructured":"Xu Y, Jia J, Xie C, Wu Y, Tu W (2018) Transient receptor potential ankyrin 1 and substance P mediate the development of gastric mucosal lesions in a water immersion restraint stress rat model. Digestion 97(3):228\u2013239. https:\/\/doi.org\/10.1159\/000484980","journal-title":"Digestion"},{"issue":"5","key":"1885_CR50","doi-asserted-by":"publisher","first-page":"761","DOI":"10.3390\/antiox10050761","volume":"10","author":"D Yeo","year":"2021","unstructured":"Yeo D, Hwang S-J, Song Y-S, Lee H-J (2021) Humulene inhibits acute gastric mucosal injury by enhancing mucosal integrity. Antioxidants 10(5):761. https:\/\/doi.org\/10.3390\/antiox10050761","journal-title":"Antioxidants"},{"issue":"4","key":"1885_CR51","doi-asserted-by":"publisher","first-page":"306","DOI":"10.58600\/eurjther-28-4-0118","volume":"28","author":"A Yolda\u015f","year":"2022","unstructured":"Yolda\u015f A, Eser N, Yaylal\u0131 A, K\u00f6kba\u015f U, Bozkurt AS (2022) Attenuation of senescence-induced oxidative exacerbations in aged rat testis by ferula elaeochytris root extract. Eur J Ther 28(4):306\u2013312. https:\/\/doi.org\/10.58600\/eurjther-28-4-0118","journal-title":"Eur J Ther"},{"issue":"3","key":"1885_CR52","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1076\/phbi.40.3.225.5830","volume":"40","author":"M Zakaria","year":"2002","unstructured":"Zakaria M, Islam M, Radhakrishnan R, Liu X, Ismail A, Kamil M, Chan K, Al-Attas A (2002) Anti-gastric ulcer and cytoprotective properties of Caralluma arabica. Pharm Biol 40(3):225\u2013230. https:\/\/doi.org\/10.1076\/phbi.40.3.225.5830","journal-title":"Pharm Biol"},{"issue":"1","key":"1885_CR53","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1007\/s00418-018-1715-4","volume":"151","author":"M Zalecki","year":"2019","unstructured":"Zalecki M (2019) Gastric ulcer induced changes in substance P and Nk1, Nk2, Nk3 receptors expression in different stomach localizations with regard to intrinsic neuronal system. Histochem Cell Biol 151(1):29\u201342. https:\/\/doi.org\/10.1007\/s00418-018-1715-4","journal-title":"Histochem Cell Biol"},{"key":"1885_CR54","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2023.114315","volume":"160","author":"C Zhou","year":"2023","unstructured":"Zhou C, Chen J, Liu K, Maharajan K, Zhang Y, Hou L, Li J, Mi M, Xia Q (2023) Isoalantolactone protects against ethanol-induced gastric ulcer via alleviating inflammation through regulation of PI3K-Akt signaling pathway and Th17 cell differentiation. Biomed Pharmacother 160:114315. https:\/\/doi.org\/10.1016\/j.biopha.2023.114315","journal-title":"Biomed Pharmacother"}],"container-title":["Inflammopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10787-025-01885-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10787-025-01885-w\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10787-025-01885-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,8]],"date-time":"2025-09-08T17:36:40Z","timestamp":1757353000000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10787-025-01885-w"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8]]},"references-count":55,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2025,8]]}},"alternative-id":["1885"],"URL":"https:\/\/doi.org\/10.1007\/s10787-025-01885-w","relation":{},"ISSN":["0925-4692","1568-5608"],"issn-type":[{"value":"0925-4692","type":"print"},{"value":"1568-5608","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,8]]},"assertion":[{"value":"22 April 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 July 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 August 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}},{"value":"Not applicable.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}}]}}