{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T16:24:40Z","timestamp":1790785480017,"version":"4.1.0"},"reference-count":159,"publisher":"Springer Science and Business Media LLC","issue":"9","license":[{"start":{"date-parts":[[2025,8,20]],"date-time":"2025-08-20T00:00:00Z","timestamp":1755648000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,8,20]],"date-time":"2025-08-20T00:00:00Z","timestamp":1755648000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Inflammopharmacol"],"published-print":{"date-parts":[[2025,9]]},"DOI":"10.1007\/s10787-025-01891-y","type":"journal-article","created":{"date-parts":[[2025,8,20]],"date-time":"2025-08-20T21:11:29Z","timestamp":1755724289000},"page":"5145-5171","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Pharmacotherapeutic potential of daidzein: insights into mechanisms and clinical relevance"],"prefix":"10.1007","volume":"33","author":[{"given":"Chinchu","family":"Praisthy LJ","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ravi","family":"Kushwah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sachin","family":"Dubey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vipin","family":"Kumar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3374-5792","authenticated-orcid":false,"given":"Smita","family":"Jain","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,8,20]]},"reference":[{"key":"1891_CR1","doi-asserted-by":"publisher","first-page":"e70008","DOI":"10.1002\/EFD2.70008","volume":"5","author":"S Ahmad","year":"2024","unstructured":"Ahmad S, Ahsan F, Ansari JA et al (2024) A review on daidzein as food supplement: exploring its phytopharmacological and preclinical status. Food 5:e70008. https:\/\/doi.org\/10.1002\/EFD2.70008","journal-title":"Food"},{"key":"1891_CR2","doi-asserted-by":"publisher","first-page":"365","DOI":"10.2174\/0929867323666161101140214","volume":"24","author":"T Ahmed","year":"2017","unstructured":"Ahmed T, Javed S, Tariq A et al (2017) Daidzein and its effects on brain. Curr Med Chem 24:365\u2013375","journal-title":"Curr Med Chem"},{"key":"1891_CR3","doi-asserted-by":"publisher","DOI":"10.1155\/2021\/6331630","author":"MM Alshehri","year":"2021","unstructured":"Alshehri MM, Sharifi-Rad J, Herrera-Bravo J et al (2021) Therapeutic potential of isoflavones with an emphasis on daidzein. Oxid Med Cell Longev. https:\/\/doi.org\/10.1155\/2021\/6331630","journal-title":"Oxid Med Cell Longev"},{"key":"1891_CR4","doi-asserted-by":"publisher","unstructured":"Altinkaynak A, Kocak O, Akcit ET et al (2025) The in vitro and in silico assessment of the cytotoxic effect of daidzein alone or in combination with 5-fluorouracil on human colorectal adenocarcinoma cell line caco-2. https:\/\/home.liebertpub.com\/jmf. https:\/\/doi.org\/10.1089\/JMF.2024.0132","DOI":"10.1089\/JMF.2024.0132"},{"key":"1891_CR5","doi-asserted-by":"publisher","first-page":"2823","DOI":"10.3390\/PLANTS12152823","volume":"12","author":"J Arora","year":"2023","unstructured":"Arora J, Kanthaliya B, Joshi A et al (2023) Evaluation of total isoflavones in chickpea (Cicer arietinum L.) sprouts germinated under precursors (p-coumaric acid and L-phenylalanine) supplementation. Plants 12:2823. https:\/\/doi.org\/10.3390\/PLANTS12152823","journal-title":"Plants"},{"key":"1891_CR6","doi-asserted-by":"publisher","first-page":"624","DOI":"10.1016\/j.bcp.2006.05.015","volume":"72","author":"KM Atherton","year":"2006","unstructured":"Atherton KM, Mutch E, Ford D (2006) Metabolism of the soyabean isoflavone daidzein by CYP1A2 and the extra-hepatic CYPs 1A1 and 1B1 affects biological activity. Biochem Pharmacol 72:624\u2013631. https:\/\/doi.org\/10.1016\/j.bcp.2006.05.015","journal-title":"Biochem Pharmacol"},{"key":"1891_CR7","doi-asserted-by":"publisher","first-page":"80","DOI":"10.1097\/GME.0000000000002080","volume":"30","author":"ND Barnard","year":"2023","unstructured":"Barnard ND, Kahleova H, Holtz DN et al (2023) A dietary intervention for vasomotor symptoms of menopause: a randomized, controlled trial. Menopause 30:80\u201387. https:\/\/doi.org\/10.1097\/GME.0000000000002080","journal-title":"Menopause"},{"key":"1891_CR8","doi-asserted-by":"publisher","first-page":"2466","DOI":"10.1021\/jf00047a019","volume":"42","author":"S Barnes","year":"1994","unstructured":"Barnes S, Kirk M, Coward L (1994) Isoflavones and their conjugates in soy foods: extraction conditions and analysis by HPLC-mass spectrometry. J Agric Food Chem 42:2466\u20132474. https:\/\/doi.org\/10.1021\/jf00047a019","journal-title":"J Agric Food Chem"},{"key":"1891_CR9","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1093\/toxsci\/62.2.205","volume":"62","author":"T Bayer","year":"2001","unstructured":"Bayer T, Colnot T, Dekant W (2001) Disposition and biotransformation of the estrogenic isoflavone daidzein in rats. Toxicol Sci 62:205\u2013211. https:\/\/doi.org\/10.1093\/toxsci\/62.2.205","journal-title":"Toxicol Sci"},{"key":"1891_CR10","doi-asserted-by":"publisher","first-page":"2004S","DOI":"10.1093\/jn\/136.7.2004S","volume":"136","author":"KM Bell","year":"2006","unstructured":"Bell KM, Pearce PD, Ugarte CE, Hendriks WH (2006) Preliminary investigation into the absorption of genistein and daidzein by domestic cats (Felis catus)1, 2, 3. J Nutr 136:2004S-2006S. https:\/\/doi.org\/10.1093\/jn\/136.7.2004S","journal-title":"J Nutr"},{"key":"1891_CR11","doi-asserted-by":"publisher","first-page":"e02669","DOI":"10.1016\/j.heliyon.2019.e02669","volume":"5","author":"Y Bhalla","year":"2019","unstructured":"Bhalla Y, Chadha K, Chadha R, Karan M (2019) Daidzein cocrystals: an opportunity to improve its biopharmaceutical parameters. Heliyon 5:e02669. https:\/\/doi.org\/10.1016\/j.heliyon.2019.e02669","journal-title":"Heliyon"},{"key":"1891_CR12","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1186\/s12935-018-0559-2","volume":"18","author":"KKL Chan","year":"2018","unstructured":"Chan KKL, Siu MKY, Jiang Y et al (2018) Estrogen receptor modulators genistein, daidzein and ERB-041 inhibit cell migration, invasion, proliferation and sphere formation via modulation of FAK and PI3K\/AKT signaling in ovarian cancer. Cancer Cell Int 18:65. https:\/\/doi.org\/10.1186\/s12935-018-0559-2","journal-title":"Cancer Cell Int"},{"key":"1891_CR13","doi-asserted-by":"publisher","first-page":"1892","DOI":"10.1021\/np50126a014","volume":"58","author":"Y-C Chang","year":"1995","unstructured":"Chang Y-C, Nair MG (1995) Metabolism of daidzein and genistein by intestinal bacteria. J Nat Prod 58:1892\u20131896. https:\/\/doi.org\/10.1021\/np50126a014","journal-title":"J Nat Prod"},{"key":"1891_CR14","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1177\/153537020523000302","volume":"230","author":"A Charlotte","year":"2005","unstructured":"Charlotte A, Frankenfeld Cara L, Lampe Johanna W (2005) Gut bacterial metabolism of the soy isoflavone daidzein: exploring the relevance to human health. Exp Biol Med 230:155\u2013170. https:\/\/doi.org\/10.1177\/153537020523000302","journal-title":"Exp Biol Med"},{"key":"1891_CR15","doi-asserted-by":"publisher","DOI":"10.1002\/CBF.4111","volume":"42","author":"A Chauhan","year":"2024","unstructured":"Chauhan A, Dubey S, Jain S (2024) Association between type 2 diabetes mellitus and Alzheimer\u2019s disease: common molecular mechanism and therapeutic targets. Cell Biochem Funct 42:e4111. https:\/\/doi.org\/10.1002\/CBF.4111","journal-title":"Cell Biochem Funct"},{"key":"1891_CR16","doi-asserted-by":"publisher","first-page":"3060","DOI":"10.1002\/PTR.8196","volume":"38","author":"VP Chavda","year":"2024","unstructured":"Chavda VP, Chaudhari AZ, Balar PC et al (2024) Phytoestrogens: chemistry, potential health benefits, and their medicinal importance. Phyther Res 38:3060\u20133079. https:\/\/doi.org\/10.1002\/PTR.8196","journal-title":"Phyther Res"},{"key":"1891_CR17","doi-asserted-by":"publisher","first-page":"3212","DOI":"10.3390\/IJMS22063212","volume":"22","author":"LR Chen","year":"2021","unstructured":"Chen LR, Chen KH (2021) Utilization of isoflavones in soybeans for women with menopausal syndrome: an overview. Int J Mol Sci 22:3212. https:\/\/doi.org\/10.3390\/IJMS22063212","journal-title":"Int J Mol Sci"},{"key":"1891_CR18","doi-asserted-by":"publisher","DOI":"10.3389\/FNBEH.2021.671864","volume":"15","author":"L Chen","year":"2021","unstructured":"Chen L, Wang X, Zhang Y et al (2021) Daidzein alleviates hypothalamic-pituitary-adrenal axis hyperactivity, ameliorates depression-like behavior, and partly rectifies circulating cytokine imbalance in two rodent models of depression. Front Behav Neurosci 15:671864. https:\/\/doi.org\/10.3389\/FNBEH.2021.671864","journal-title":"Front Behav Neurosci"},{"key":"1891_CR19","doi-asserted-by":"publisher","first-page":"136","DOI":"10.1016\/j.jnutbio.2013.09.012","volume":"25","author":"SH Cheong","year":"2014","unstructured":"Cheong SH, Furuhashi K, Ito K et al (2014) Daidzein promotes glucose uptake through glucose transporter 4 translocation to plasma membrane in L6 myocytes and improves glucose homeostasis in Type 2 diabetic model mice. J Nutr Biochem 25:136\u2013143. https:\/\/doi.org\/10.1016\/j.jnutbio.2013.09.012","journal-title":"J Nutr Biochem"},{"key":"1891_CR20","doi-asserted-by":"publisher","first-page":"381","DOI":"10.4162\/NRP.2011.5.5.381","volume":"5","author":"HY Cho","year":"2011","unstructured":"Cho HY, Park CM, Kim MJ et al (2011) Comparative effect of genistein and daidzein on the expression of MCP-1, eNOS, and cell adhesion molecules in TNF-\u03b1-stimulated HUVECs. Nutr Res Pract 5:381\u2013388. https:\/\/doi.org\/10.4162\/NRP.2011.5.5.381","journal-title":"Nutr Res Pract"},{"key":"1891_CR21","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1002\/dmrr.780","volume":"24","author":"MS Choi","year":"2008","unstructured":"Choi MS, Jung UJ, Yeo J et al (2008) Genistein and daidzein prevent diabetes onset by elevating insulin level and altering hepatic gluconeogenic and lipogenic enzyme activities in non-obese diabetic (NOD) mice. Diabetes Metab Res Rev 24:74\u201381. https:\/\/doi.org\/10.1002\/dmrr.780","journal-title":"Diabetes Metab Res Rev"},{"key":"1891_CR22","doi-asserted-by":"publisher","first-page":"204","DOI":"10.1111\/J.1600-0765.2011.01422.X","volume":"47","author":"EY Choi","year":"2012","unstructured":"Choi EY, Jin JY, Lee JY et al (2012) Anti-inflammatory effects and the underlying mechanisms of action of daidzein in murine macrophages stimulated with Prevotella intermedia lipopolysaccharide. J Periodontal Res 47:204\u2013211. https:\/\/doi.org\/10.1111\/J.1600-0765.2011.01422.X","journal-title":"J Periodontal Res"},{"key":"1891_CR23","doi-asserted-by":"publisher","first-page":"1328","DOI":"10.1248\/BPB.25.1328","volume":"25","author":"MK Choo","year":"2002","unstructured":"Choo MK, Park EK, Yoon HK, Kim DH (2002) Antithrombotic and antiallergic activities of daidzein, a metabolite of puerarin and daidzin produced by human intestinal microflora. Biol Pharm Bull 25:1328\u20131332. https:\/\/doi.org\/10.1248\/BPB.25.1328","journal-title":"Biol Pharm Bull"},{"key":"1891_CR24","doi-asserted-by":"publisher","DOI":"10.25004\/IJPSDR.2024.160413","author":"A Chourasia","year":"2024","unstructured":"Chourasia A, Lodhi S (2024) Pharmacological evaluation of daidzein-loaded solid lipid nanoparticle gel for anti-inflammatory effect in experimental animals. Int J Pharm Sci Drug Res. https:\/\/doi.org\/10.25004\/IJPSDR.2024.160413","journal-title":"Int J Pharm Sci Drug Res"},{"key":"1891_CR25","doi-asserted-by":"crossref","unstructured":"Clavel T, Mapesa JO (2013) Phenolics in human nutrition: importance of the intestinal microbiome for isoflavone and lignan bioavailability BT\u2014natural products: phytochemistry, botany and metabolism of alkaloids, phenolics and terpenes. In: Ramawat KG, M\u00e9rillon J-M (eds) Springer, Berlin, pp 2433\u20132463","DOI":"10.1007\/978-3-642-22144-6_94"},{"key":"1891_CR26","first-page":"7898","volume":"13","author":"D Dalal","year":"2024","unstructured":"Dalal D, Singh L, Singh A (2024) Mechanistic insight unrevealing the potential of Diadzein in ameliorating the Alzheimer\u2019s disease. Front Health Inf 13:7898\u20137906","journal-title":"Front Health Inf"},{"key":"1891_CR27","doi-asserted-by":"publisher","first-page":"407","DOI":"10.1002\/BIOF.1439","volume":"44","author":"D Das","year":"2018","unstructured":"Das D, Sarkar S, Bordoloi J et al (2018) Daidzein, its effects on impaired glucose and lipid metabolism and vascular inflammation associated with type 2 diabetes. BioFactors 44:407\u2013417. https:\/\/doi.org\/10.1002\/BIOF.1439","journal-title":"BioFactors"},{"key":"1891_CR28","doi-asserted-by":"publisher","first-page":"1138","DOI":"10.1093\/jaoac\/89.4.1138","volume":"89","author":"P Delmonte","year":"2006","unstructured":"Delmonte P, Rader JI (2006) Analysis of isoflavones in foods and dietary supplements. J AOAC Int 89:1138\u20131146. https:\/\/doi.org\/10.1093\/jaoac\/89.4.1138","journal-title":"J AOAC Int"},{"key":"1891_CR29","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1016\/B978-0-12-411512-5.00002-6","volume":"68","author":"PW Dickson","year":"2013","unstructured":"Dickson PW, Briggs GD (2013) Tyrosine hydroxylase. Regulation by feedback inhibition and phosphorylation. Adv Pharmacol 68:13\u201321. https:\/\/doi.org\/10.1016\/B978-0-12-411512-5.00002-6","journal-title":"Adv Pharmacol"},{"key":"1891_CR30","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-030-92196-5_5","author":"B Dinda","year":"2022","unstructured":"Dinda B, Dinda S, Chakraborty M (2022) Pharmacology of anti-obesity and antidiabetic phytochemicals isolated from various natural sources (plants, seaweeds, mushrooms, marine animals, and microorganisms). Nat Prod Obes Diabetes Ther Potential Role Prev Treat. https:\/\/doi.org\/10.1007\/978-3-030-92196-5_5","journal-title":"Nat Prod Obes Diabetes Ther Potential Role Prev Treat"},{"key":"1891_CR31","doi-asserted-by":"publisher","first-page":"2456","DOI":"10.3390\/NU12082456","volume":"12","author":"I Dom\u00ednguez-L\u00f3pez","year":"2020","unstructured":"Dom\u00ednguez-L\u00f3pez I, Yago-Arag\u00f3n M, Salas-Huetos A et al (2020) Effects of dietary phytoestrogens on hormones throughout a human lifespan: a review. Nutrtion 12:2456. https:\/\/doi.org\/10.3390\/NU12082456","journal-title":"Nutrtion"},{"key":"1891_CR32","doi-asserted-by":"publisher","first-page":"392","DOI":"10.1016\/j.intimp.2015.04.002","volume":"26","author":"G Feng","year":"2015","unstructured":"Feng G, Sun B, Li T (2015) Daidzein attenuates lipopolysaccharide-induced acute lung injury via toll-like receptor 4\/NF-kappaB pathway. Int Immunopharmacol 26:392\u2013400. https:\/\/doi.org\/10.1016\/j.intimp.2015.04.002","journal-title":"Int Immunopharmacol"},{"key":"1891_CR33","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3390\/molecules24162975","volume":"24","author":"Y Fujitaka","year":"2019","unstructured":"Fujitaka Y, Hamada H, Uesugi D et al (2019) Synthesis of daidzein glycosides, \u03b1-tocopherol glycosides, hesperetin glycosides by bioconversion and their potential for anti-allergic functional-foods and cosmetics. Molecules 24:1\u201311. https:\/\/doi.org\/10.3390\/molecules24162975","journal-title":"Molecules"},{"key":"1891_CR34","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3390\/IJMS21176275","volume":"21","author":"U Galicia-Garcia","year":"2020","unstructured":"Galicia-Garcia U, Benito-Vicente A, Jebari S et al (2020) Pathophysiology of type 2 diabetes mellitus. Int J Mol Sci 21:1\u201334. https:\/\/doi.org\/10.3390\/IJMS21176275","journal-title":"Int J Mol Sci"},{"key":"1891_CR35","doi-asserted-by":"publisher","first-page":"4129","DOI":"10.1016\/j.biomaterials.2008.07.008","volume":"29","author":"Y Gao","year":"2008","unstructured":"Gao Y, Gu W, Chen L et al (2008) The role of daidzein-loaded sterically stabilized solid lipid nanoparticles in therapy for cardio-cerebrovascular diseases. Biomaterials 29:4129\u20134136. https:\/\/doi.org\/10.1016\/j.biomaterials.2008.07.008","journal-title":"Biomaterials"},{"key":"1891_CR36","doi-asserted-by":"publisher","first-page":"2967","DOI":"10.1038\/S41598-025-85463-8","volume":"15","author":"N Gautam","year":"2025","unstructured":"Gautam N, Dutta D, Mittal S et al (2025) QbD-Driven preparation, characterization, and pharmacokinetic investigation of daidzein-l oaded nano-cargos of hydroxyapatite. Sci Rep 15:2967. https:\/\/doi.org\/10.1038\/S41598-025-85463-8","journal-title":"Sci Rep"},{"key":"1891_CR37","doi-asserted-by":"publisher","first-page":"2254","DOI":"10.3923\/pjbs.2008.2254.2258","volume":"11","author":"S Golkhoo","year":"2008","unstructured":"Golkhoo S, Ahmadi AR, Hanachi P et al (2008) Determination of daidzein and genistein in soy milk in Iran by using HPLC analysis method. Pakistan J Biol Sci 11:2254\u20132258","journal-title":"Pakistan J Biol Sci"},{"key":"1891_CR38","doi-asserted-by":"publisher","first-page":"986","DOI":"10.1016\/J.FSHW.2022.10.020","volume":"12","author":"O Golovinskaia","year":"2023","unstructured":"Golovinskaia O, Wang CK (2023) The hypoglycemic potential of phenolics from functional foods and their mechanisms. Food Sci Hum Wellness 12:986\u20131007. https:\/\/doi.org\/10.1016\/J.FSHW.2022.10.020","journal-title":"Food Sci Hum Wellness"},{"key":"1891_CR39","doi-asserted-by":"publisher","first-page":"607","DOI":"10.1079\/BJN2003820","volume":"89","author":"N Gottstein","year":"2003","unstructured":"Gottstein N, Ewins BA, Eccleston C et al (2003) Effect of genistein and daidzein on platelet aggregation and monocyte and endothelial function. Br J Nutr 89:607\u2013615. https:\/\/doi.org\/10.1079\/BJN2003820","journal-title":"Br J Nutr"},{"key":"1891_CR40","doi-asserted-by":"publisher","first-page":"58","DOI":"10.3390\/CELLS14010058","volume":"14","author":"E Greygoose","year":"2025","unstructured":"Greygoose E, Metharom P, Kula H et al (2025) The Estrogen-Immune Interface in Endometriosis. Cells 14:58. https:\/\/doi.org\/10.3390\/CELLS14010058","journal-title":"Cells"},{"key":"1891_CR41","doi-asserted-by":"publisher","DOI":"10.3389\/fpls.2017.00567","author":"OP Gupta","year":"2017","unstructured":"Gupta OP, Nigam D, Dahuja A et al (2017) Regulation of isoflavone biosynthesis by miRNAs in two contrasting soybean genotypes at different seed developmental stages. Front Plant Sci. https:\/\/doi.org\/10.3389\/fpls.2017.00567","journal-title":"Front Plant Sci"},{"key":"1891_CR42","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1016\/j.cbpc.2022.109364","volume":"258","author":"A Guru","year":"2022","unstructured":"Guru A, Sudhakaran G, Velayutham M et al (2022) Daidzein normalized gentamicin-induced nephrotoxicity and associated pro-inflammatory cytokines in MDCK and zebrafish: possible mechanism of nephroprotection. Comp Biochem Physiol Part C Toxicol Pharmacol 258:8. https:\/\/doi.org\/10.1016\/j.cbpc.2022.109364","journal-title":"Comp Biochem Physiol Part C Toxicol Pharmacol"},{"key":"1891_CR43","doi-asserted-by":"publisher","unstructured":"Hammad M, Hassan U, Shahbaz M et al (2025) Isoflavones: promising natural agent for cancer prevention and treatment. https:\/\/doi.org\/10.1002\/fsn3.70091","DOI":"10.1002\/fsn3.70091"},{"key":"1891_CR44","doi-asserted-by":"publisher","first-page":"1628","DOI":"10.25122\/JML-2023-0082","volume":"16","author":"HZ Hammoodi","year":"2023","unstructured":"Hammoodi HZ, Al-Shawi NN (2023) Neuroprotective effects of daidzein against ifosfamide-induced neurotoxicity in male rats: role of selected inflammatory and apoptotic markers. J Med Life 16:1628. https:\/\/doi.org\/10.25122\/JML-2023-0082","journal-title":"J Med Life"},{"key":"1891_CR45","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3390\/nu16050651","volume":"16","author":"IA Harahap","year":"2024","unstructured":"Harahap IA, Kuligowski M, Cieslak A et al (2024) Effect of tempeh and Daidzein on calcium status, calcium transporters, and bone metabolism biomarkers in ovariectomized rats. Nutrients 16:1\u201325. https:\/\/doi.org\/10.3390\/nu16050651","journal-title":"Nutrients"},{"key":"1891_CR46","doi-asserted-by":"publisher","first-page":"2947","DOI":"10.1111\/BPH.16382","volume":"181","author":"B Haridevamuthu","year":"2024","unstructured":"Haridevamuthu B, Sudhakaran G, Pachaiappan R et al (2024) Daidzein ameliorates nonmotor symptoms of manganese-induced Parkinsonism in zebrafish model: behavioural and biochemical approach. Br J Pharmacol 181:2947\u20132963. https:\/\/doi.org\/10.1111\/BPH.16382","journal-title":"Br J Pharmacol"},{"key":"1891_CR47","doi-asserted-by":"publisher","first-page":"1350","DOI":"10.1016\/J.FOODCHEM.2009.01.053","volume":"115","author":"H Haron","year":"2009","unstructured":"Haron H, Ismail A, Azlan A et al (2009) Daidzein and genestein contents in tempeh and selected soy products. Food Chem 115:1350\u20131356. https:\/\/doi.org\/10.1016\/J.FOODCHEM.2009.01.053","journal-title":"Food Chem"},{"key":"1891_CR48","doi-asserted-by":"publisher","first-page":"722","DOI":"10.1124\/JPET.105.090456","volume":"315","author":"C Hermenegildo","year":"2005","unstructured":"Hermenegildo C, Oviedo PJ, Garc\u00eda-P\u00e9rez MA et al (2005) Effects of phytoestrogens genistein and daidzein on prostacyclin production by human endothelial cells. J Pharmacol Exp Ther 315:722\u2013728. https:\/\/doi.org\/10.1124\/JPET.105.090456","journal-title":"J Pharmacol Exp Ther"},{"key":"1891_CR49","doi-asserted-by":"publisher","first-page":"533","DOI":"10.1016\/J.NRLENG.2015.06.019","volume":"32","author":"D Hernandez-Baltazar","year":"2017","unstructured":"Hernandez-Baltazar D, Zavala-Flores LM, Villanueva-Olivo A (2017) The 6-hydroxydopamine model and parkinsonian pathophysiology: novel findings in an older model. Neurol (Engl Ed) 32:533\u2013539. https:\/\/doi.org\/10.1016\/J.NRLENG.2015.06.019","journal-title":"Neurol (Engl Ed)"},{"key":"1891_CR50","doi-asserted-by":"publisher","first-page":"11985","DOI":"10.3390\/IJMS241511985","volume":"24","author":"HJ Hong","year":"2023","unstructured":"Hong HJ, Nam GS, Nam KS (2023) Daidzein inhibits human platelet activation by downregulating thromboxane A2 production and granule release, regardless of COX-1 activity. Int J Mol Sci 24:11985. https:\/\/doi.org\/10.3390\/IJMS241511985","journal-title":"Int J Mol Sci"},{"key":"1891_CR51","doi-asserted-by":"publisher","first-page":"297","DOI":"10.1016\/j.molcatb.2008.11.013","volume":"59","author":"K Horii","year":"2009","unstructured":"Horii K, Adachi T, Matsuda T et al (2009) Improvement of isoflavone aglycones production using \u03b2-glucosidase secretory produced in recombinant Aspergillus oryzae. J Mol Catal B Enzym 59:297\u2013301. https:\/\/doi.org\/10.1016\/j.molcatb.2008.11.013","journal-title":"J Mol Catal B Enzym"},{"key":"1891_CR52","doi-asserted-by":"publisher","first-page":"1238","DOI":"10.3390\/NU11061238","volume":"11","author":"D Hou","year":"2019","unstructured":"Hou D, Yousaf L, Xue Y et al (2019) Mung bean (Vigna radiata L.): bioactive polyphenols, polysaccharides, peptides, and health benefits. Nutrients 11:1238. https:\/\/doi.org\/10.3390\/NU11061238","journal-title":"Nutrients"},{"key":"1891_CR53","doi-asserted-by":"publisher","first-page":"586","DOI":"10.3390\/MOLECULES21050586","volume":"21","author":"C Huang","year":"2016","unstructured":"Huang C, Pang D, Luo Q et al (2016) Soy isoflavones regulate lipid metabolism through an AKT\/mTORC1 pathway in diet-induced obesity (DIO) male rats. Molecules 21:586. https:\/\/doi.org\/10.3390\/MOLECULES21050586","journal-title":"Molecules"},{"key":"1891_CR54","doi-asserted-by":"publisher","first-page":"2982","DOI":"10.1016\/j.xphs.2019.04.017","volume":"108","author":"S Huang","year":"2019","unstructured":"Huang S, Xue Q, Xu J et al (2019) Simultaneously improving the physicochemical properties, dissolution performance, and bioavailability of apigenin and daidzein by co-crystallization with theophylline. J Pharm Sci 108:2982\u20132993. https:\/\/doi.org\/10.1016\/j.xphs.2019.04.017","journal-title":"J Pharm Sci"},{"key":"1891_CR55","doi-asserted-by":"publisher","first-page":"100063","DOI":"10.1016\/J.AMOLM.2025.100063","volume":"5","author":"NH Hussen","year":"2025","unstructured":"Hussen NH, Abdulla SK, Ali NM et al (2025) Role of antioxidants in skin aging and the molecular mechanism of ROS: a comprehensive review. Asp Mol Med 5:100063. https:\/\/doi.org\/10.1016\/J.AMOLM.2025.100063","journal-title":"Asp Mol Med"},{"key":"1891_CR56","doi-asserted-by":"publisher","first-page":"380","DOI":"10.3390\/BIOM15030380","volume":"15","author":"I Imtiaz","year":"2025","unstructured":"Imtiaz I, Schloss J, Bugarcic A (2025) Interplay between traditional and scientific knowledge: phytoconstituents and their roles in lung and colorectal cancer signaling pathways. Biomol 15:380. https:\/\/doi.org\/10.3390\/BIOM15030380","journal-title":"Biomol"},{"key":"1891_CR57","doi-asserted-by":"publisher","DOI":"10.1016\/J.PHANU.2023.100337","volume":"24","author":"S Ito","year":"2023","unstructured":"Ito S, Sasaki H, Gotow T et al (2023) Soy isoflavone daidzein protects Neuro2a cells from NO stress via activation of AMPK-PGC1\u03b1 pathway followed by mitochondrial enhancement. Pharm Nutr 24:100337. https:\/\/doi.org\/10.1016\/J.PHANU.2023.100337","journal-title":"Pharm Nutr"},{"key":"1891_CR58","doi-asserted-by":"publisher","first-page":"925","DOI":"10.1007\/S12033-014-9772-Y","volume":"56","author":"S Jain","year":"2014","unstructured":"Jain S, Kumar A, Mamidi S, McPhee K (2014) Genetic diversity and population structure among pea (Pisum sativum L.) cultivars as revealed by simple sequence repeat and novel genic markers. Mol Biotechnol 56:925\u2013938. https:\/\/doi.org\/10.1007\/S12033-014-9772-Y","journal-title":"Mol Biotechnol"},{"key":"1891_CR59","doi-asserted-by":"publisher","first-page":"2097","DOI":"10.2174\/1389557523666230511122435","volume":"23","author":"S Jain","year":"2023","unstructured":"Jain S, Singh R, Paliwal S, Sharma S (2023) Targeting neuroinflammation as disease modifying approach to Alzheimer\u2019s disease: potential and challenges. Mini Rev Med Chem 23:2097\u20132116. https:\/\/doi.org\/10.2174\/1389557523666230511122435","journal-title":"Mini Rev Med Chem"},{"key":"1891_CR60","doi-asserted-by":"publisher","first-page":"709","DOI":"10.1016\/S0006-2952(02)01585-X","volume":"65","author":"TL Jia","year":"2003","unstructured":"Jia TL, Wang HZ, Xie LP et al (2003) Daidzein enhances osteoblast growth that may be mediated by increased bone morphogenetic protein (BMP) production. Biochem Pharmacol 65:709\u2013715. https:\/\/doi.org\/10.1016\/S0006-2952(02)01585-X","journal-title":"Biochem Pharmacol"},{"key":"1891_CR61","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1093\/ANNONC\/MDP499","volume":"21","author":"S Jin","year":"2010","unstructured":"Jin S, Zhang QY, Kang XM et al (2010) Daidzein induces MCF-7 breast cancer cell apoptosis via the mitochondrial pathway. Ann Oncol 21:263\u2013268. https:\/\/doi.org\/10.1093\/ANNONC\/MDP499","journal-title":"Ann Oncol"},{"key":"1891_CR62","doi-asserted-by":"publisher","first-page":"1185317","DOI":"10.3389\/FIMMU.2023.1185317","volume":"14","author":"Q Jin","year":"2023","unstructured":"Jin Q, Liu T, Qiao Y et al (2023) Oxidative stress and inflammation in diabetic nephropathy: role of polyphenols. Front Immunol 14:1185317. https:\/\/doi.org\/10.3389\/FIMMU.2023.1185317","journal-title":"Front Immunol"},{"key":"1891_CR63","doi-asserted-by":"publisher","first-page":"512","DOI":"10.1007\/S11130-020-00840-0","volume":"75","author":"SL Johnson","year":"2020","unstructured":"Johnson SL, Park HY, Vattem DA et al (2020) Equol, a blood-brain barrier permeable gut microbial metabolite of dietary isoflavone daidzein, exhibits neuroprotective effects against neurotoxins induced toxicity in human neuroblastoma SH-SY5Y cells and Caenorhabditis elegans. Plant Foods Hum Nutr 75:512\u2013517. https:\/\/doi.org\/10.1007\/S11130-020-00840-0","journal-title":"Plant Foods Hum Nutr"},{"key":"1891_CR64","doi-asserted-by":"publisher","first-page":"433","DOI":"10.4049\/JIMMUNOL.1101375","volume":"189","author":"MW Julian","year":"2012","unstructured":"Julian MW, Shao G, Bao S et al (2012) Mitochondrial transcription factor A (TFAM) serves as a danger signal by augmenting plasmacytoid dendritic cell responses to DNA. J Immunol 189:433. https:\/\/doi.org\/10.4049\/JIMMUNOL.1101375","journal-title":"J Immunol"},{"key":"1891_CR65","doi-asserted-by":"publisher","first-page":"208","DOI":"10.1038\/72671","volume":"18","author":"W Jung","year":"2000","unstructured":"Jung W, Yu O, Lau S-MC et al (2000) Identification and expression of isoflavone synthase, the key enzyme for biosynthesis of isoflavones in legumes. Nat Biotechnol 18:208\u2013212. https:\/\/doi.org\/10.1038\/72671","journal-title":"Nat Biotechnol"},{"key":"1891_CR66","doi-asserted-by":"publisher","first-page":"111","DOI":"10.4103\/0973-7847.70900","volume":"4","author":"V Kalaiselvan","year":"2010","unstructured":"Kalaiselvan V, Kalaivani M, Vijayakumar A et al (2010) Current knowledge and future direction of research on soy isoflavones as a therapeutic agents. Pharmacogn Rev 4:111\u2013117. https:\/\/doi.org\/10.4103\/0973-7847.70900","journal-title":"Pharmacogn Rev"},{"key":"1891_CR67","doi-asserted-by":"publisher","first-page":"4256","DOI":"10.2174\/092986710793348581","volume":"17","author":"N Kashihara","year":"2010","unstructured":"Kashihara N, Haruna Y, Kondeti VK, Kanwar YS (2010) Oxidative stress in diabetic nephropathy. Curr Med Chem 17:4256\u20134269","journal-title":"Curr Med Chem"},{"key":"1891_CR68","doi-asserted-by":"publisher","first-page":"119","DOI":"10.3390\/LIVERS2030011","volume":"2","author":"A Khan","year":"2022","unstructured":"Khan A, Chauhan K, Ross H et al (2022) A comprehensive review on the use of herbal dietary supplements in the USA, reasons for their use, and review of potential hepatotoxicity. Livers 2:119\u2013138. https:\/\/doi.org\/10.3390\/LIVERS2030011","journal-title":"Livers"},{"key":"1891_CR69","doi-asserted-by":"publisher","first-page":"947","DOI":"10.18203\/2320-1770.IJRCOG20180871","volume":"7","author":"F Khatoon","year":"2018","unstructured":"Khatoon F, Sinha P, Shahid S, Gupta U (2018) Assessment of menopausal symptoms using modified menopause rating scale (MRS) in women of Northern India. Int J Reprod Contraception Obstet Gynecol 7:947\u2013951. https:\/\/doi.org\/10.18203\/2320-1770.IJRCOG20180871","journal-title":"Int J Reprod Contraception Obstet Gynecol"},{"key":"1891_CR70","doi-asserted-by":"publisher","first-page":"867","DOI":"10.1093\/ajcn\/67.5.867","volume":"67","author":"RA King","year":"1998","unstructured":"King RA, Bursill DB (1998) Plasma and urinary kinetics of the isoflavones daidzein and genistein after a single soy meal in humans. Am J Clin Nutr 67:867\u2013872. https:\/\/doi.org\/10.1093\/ajcn\/67.5.867","journal-title":"Am J Clin Nutr"},{"key":"1891_CR71","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1016\/j.jnutbio.2019.108315","volume":"77","author":"K Kitamura","year":"2020","unstructured":"Kitamura K, Erlangga JS, Tsukamoto S et al (2020) Daidzein promotes the expression of oxidative phosphorylation- and fatty acid oxidation-related genes via an estrogen-related receptor \u03b1 pathway to decrease lipid accumulation in muscle cells. J Nutr Biochem 77:25. https:\/\/doi.org\/10.1016\/j.jnutbio.2019.108315","journal-title":"J Nutr Biochem"},{"key":"1891_CR72","doi-asserted-by":"publisher","first-page":"1081","DOI":"10.1007\/S12272-019-01191-4","volume":"42","author":"YH Ko","year":"2019","unstructured":"Ko YH, Kwon SH, Kim SK et al (2019) Protective effects of 6,7,4\u2032-trihydroxyisoflavone, a major metabolite of daidzein, on 6-hydroxydopamine-induced neuronal cell death in SH-SY5Y human neuroblastoma cells. Arch Pharm Res 42:1081\u20131091. https:\/\/doi.org\/10.1007\/S12272-019-01191-4","journal-title":"Arch Pharm Res"},{"key":"1891_CR73","doi-asserted-by":"publisher","first-page":"523","DOI":"10.1016\/0014-5793(95)01398-9","volume":"377","author":"T Krumm","year":"1995","unstructured":"Krumm T, Bandemer K, Boland W (1995) Induction of volatile biosynthesis in the lima bean (Phaseolus lunatus) by leucine- and isoleucine conjugates of 1-oxo- and 1-hydroxyindan-4-carboxylic acid: evidence for amino acid conjugates of jasmonic acid as intermediates in the octadecanoid signalling pathway. FEBS Lett 377:523\u2013529. https:\/\/doi.org\/10.1016\/0014-5793(95)01398-9","journal-title":"FEBS Lett"},{"key":"1891_CR74","doi-asserted-by":"publisher","first-page":"329","DOI":"10.3390\/NU16020329","volume":"16","author":"SH Kwan","year":"2024","unstructured":"Kwan SH, Gonzalez de Mejia E (2024) The potential of the adzuki bean (Vigna angularis) and its bioactive compounds in managing type 2 diabetes and glucose metabolism: a narrative review. Nutrients 16:329. https:\/\/doi.org\/10.3390\/NU16020329","journal-title":"Nutrients"},{"key":"1891_CR75","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.nutres.2009.11.004","volume":"30","author":"DY Kwon","year":"2010","unstructured":"Kwon DY, Daily JW, Kim HJ, Park S (2010) Antidiabetic effects of fermented soybean products on type 2 diabetes. Nutr Res 30:1\u201313. https:\/\/doi.org\/10.1016\/j.nutres.2009.11.004","journal-title":"Nutr Res"},{"key":"1891_CR76","doi-asserted-by":"publisher","DOI":"10.1016\/J.LFS.2020.118779","volume":"265","author":"AP Laddha","year":"2021","unstructured":"Laddha AP, Kulkarni YA (2021) Daidzein ameliorates diabetic retinopathy in experimental animals. Life Sci 265:118779. https:\/\/doi.org\/10.1016\/J.LFS.2020.118779","journal-title":"Life Sci"},{"key":"1891_CR77","doi-asserted-by":"publisher","first-page":"1408","DOI":"10.1080\/01480545.2020.1833906","volume":"45","author":"AP Laddha","year":"2022","unstructured":"Laddha AP, Kulkarni YA (2022) In-vivo and in-silico toxicity studies of daidzein: an isoflavone from soy. Drug Chem Toxicol 45:1408\u20131416. https:\/\/doi.org\/10.1080\/01480545.2020.1833906","journal-title":"Drug Chem Toxicol"},{"key":"1891_CR78","doi-asserted-by":"publisher","first-page":"315","DOI":"10.1016\/S0039-128X(96)00226-7","volume":"62","author":"O Lap\u010d\u00edk","year":"1997","unstructured":"Lap\u010d\u00edk O, Hampl R, Al-Maharik N et al (1997) A novel radioimmunoassay for daidzein. Steroids 62:315\u2013320. https:\/\/doi.org\/10.1016\/S0039-128X(96)00226-7","journal-title":"Steroids"},{"key":"1891_CR79","doi-asserted-by":"publisher","first-page":"14246","DOI":"10.1074\/jbc.M110.147348","volume":"286","author":"DE Lee","year":"2011","unstructured":"Lee DE, Lee KW, Byun S et al (2011) 7,3\u2032,4\u2032-trihydroxyisoflavone, a metabolite of the soy isoflavone daidzein, suppresses ultraviolet B-induced skin cancer by targeting cot and MKK4*. J Biol Chem 286:14246\u201314256. https:\/\/doi.org\/10.1074\/jbc.M110.147348","journal-title":"J Biol Chem"},{"key":"1891_CR80","doi-asserted-by":"publisher","first-page":"576","DOI":"10.1016\/J.BBADIS.2016.01.003","volume":"1862","author":"P Lepetsos","year":"2016","unstructured":"Lepetsos P, Papavassiliou AG (2016) ROS\/oxidative stress signaling in osteoarthritis. Biochim Biophys Acta Mol Basis Dis 1862:576\u2013591. https:\/\/doi.org\/10.1016\/J.BBADIS.2016.01.003","journal-title":"Biochim Biophys Acta Mol Basis Dis"},{"key":"1891_CR81","doi-asserted-by":"publisher","first-page":"496","DOI":"10.1038\/aps.2013.191","volume":"35","author":"H Li","year":"2014","unstructured":"Li H, Pan L, Ke Y et al (2014) Daidzein suppresses pro-inflammatory chemokine Cxcl2 transcription in TNF-\u03b1-stimulated murine lung epithelial cells via depressing PARP-1 activity. Acta Pharmacol Sin 35:496\u2013503. https:\/\/doi.org\/10.1038\/aps.2013.191","journal-title":"Acta Pharmacol Sin"},{"key":"1891_CR82","doi-asserted-by":"publisher","DOI":"10.3389\/FCVM.2022.988266","volume":"9","author":"W Li","year":"2022","unstructured":"Li W, Jin K, Luo J et al (2022) NF-\u03baB and its crosstalk with endoplasmic reticulum stress in atherosclerosis. Front Cardiovasc Med 9:988266. https:\/\/doi.org\/10.3389\/FCVM.2022.988266","journal-title":"Front Cardiovasc Med"},{"key":"1891_CR83","doi-asserted-by":"publisher","DOI":"10.29219\/FNR.V62.1384","author":"YS Liang","year":"2018","unstructured":"Liang YS, Qi WT, Guo W et al (2018) Genistein and daidzein induce apoptosis of colon cancer cells by inhibiting the accumulation of lipid droplets. Food Nutr Res. https:\/\/doi.org\/10.29219\/FNR.V62.1384","journal-title":"Food Nutr Res"},{"key":"1891_CR84","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1016\/J.JNUTBIO.2016.02.012","volume":"32","author":"IC Lin","year":"2016","unstructured":"Lin IC, Yamashita S, Murata M et al (2016) Equol suppresses inflammatory response and bone erosion due to rheumatoid arthritis in mice. J Nutr Biochem 32:101\u2013106. https:\/\/doi.org\/10.1016\/J.JNUTBIO.2016.02.012","journal-title":"J Nutr Biochem"},{"key":"1891_CR85","doi-asserted-by":"publisher","first-page":"2098","DOI":"10.3382\/PS\/PEW483","volume":"96","author":"J Lu","year":"2017","unstructured":"Lu J, Qu L, Shen MM et al (2017) Safety evaluation of daidzein in laying hens: Effects on laying performance, hatchability, egg quality, clinical blood parameters, and organ development. Poult Sci 96:2098\u20132103. https:\/\/doi.org\/10.3382\/PS\/PEW483","journal-title":"Poult Sci"},{"key":"1891_CR86","doi-asserted-by":"publisher","DOI":"10.1016\/J.MEDJ.2024.07.024","volume":"6","author":"J Lu","year":"2025","unstructured":"Lu J, Liu R, Ren H et al (2025) Impact of omega-3 fatty acids on hypertriglyceridemia, lipidomics, and gut microbiome in patients with type 2 diabetes. Medicine 6:100496. https:\/\/doi.org\/10.1016\/J.MEDJ.2024.07.024","journal-title":"Medicine"},{"key":"1891_CR87","doi-asserted-by":"crossref","unstructured":"Luan F, Tang LL, Chen XX, Liu HT (2017) Simultaneous determination of daidzein, genistein and formononetin in coffee by capillary zone electrophoresis. Separations 4","DOI":"10.3390\/separations4010001"},{"key":"1891_CR88","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1186\/s13099-024-00625-9","volume":"16","author":"J Lv","year":"2024","unstructured":"Lv J, Jin S, Zhang Y et al (2024) Equol: a metabolite of gut microbiota with potential antitumor effects. Gut Pathog 16:35. https:\/\/doi.org\/10.1186\/s13099-024-00625-9","journal-title":"Gut Pathog"},{"key":"1891_CR89","doi-asserted-by":"publisher","first-page":"559","DOI":"10.2147\/ijn.s27641","volume":"7","author":"Y Ma","year":"2012","unstructured":"Ma Y, Zhao X, Li J, Shen Q (2012) The comparison of different daidzein-PLGA nanoparticles in increasing its oral bioavailability. Int J Nanomedicine 7:559\u2013570. https:\/\/doi.org\/10.2147\/ijn.s27641","journal-title":"Int J Nanomedicine"},{"key":"1891_CR90","doi-asserted-by":"publisher","DOI":"10.3389\/FONC.2020.587386","volume":"10","author":"R Mal","year":"2020","unstructured":"Mal R, Magner A, David J et al (2020) Estrogen receptor beta (ER\u03b2): a ligand activated tumor suppressor. Front Oncol 10:587386. https:\/\/doi.org\/10.3389\/FONC.2020.587386","journal-title":"Front Oncol"},{"key":"1891_CR91","doi-asserted-by":"publisher","DOI":"10.1016\/J.JDDST.2024.105843","volume":"98","author":"B Mangla","year":"2024","unstructured":"Mangla B, Kaur A, Kumar P et al (2024) Development of nanobigel system combining apoptosis-inducing daidzein and flaxseed oil for the synergistic treatment of skin cancer. J Drug Deliv Sci Technol 98:105843. https:\/\/doi.org\/10.1016\/J.JDDST.2024.105843","journal-title":"J Drug Deliv Sci Technol"},{"key":"1891_CR92","doi-asserted-by":"publisher","first-page":"1455","DOI":"10.3390\/12071455","volume":"12","author":"Z Mao","year":"2007","unstructured":"Mao Z, Zheng YL, Zhang YQ et al (2007) The anti-apoptosis effects of daidzein in the brain of D-galactose treated mice. Molecules 12:1455\u20131470. https:\/\/doi.org\/10.3390\/12071455","journal-title":"Molecules"},{"key":"1891_CR93","doi-asserted-by":"publisher","first-page":"25","DOI":"10.3390\/NU11092231","volume":"11","author":"B Mayo","year":"2019","unstructured":"Mayo B, V\u00e1zquez L, Fl\u00f3rez AB (2019) Equol: A bacterial metabolite from the Daidzein isoflavone and its presumed beneficial health effects. Nutrients 11:25. https:\/\/doi.org\/10.3390\/NU11092231","journal-title":"Nutrients"},{"key":"1891_CR94","doi-asserted-by":"publisher","DOI":"10.3389\/FNUT.2022.970364","volume":"9","author":"M Messina","year":"2022","unstructured":"Messina M, Duncan A, Messina V et al (2022) The health effects of soy: a reference guide for health professionals. Front Nutr 9:970364. https:\/\/doi.org\/10.3389\/FNUT.2022.970364","journal-title":"Front Nutr"},{"key":"1891_CR95","doi-asserted-by":"publisher","first-page":"2697","DOI":"10.3390\/NU16162697\/S1","volume":"16","author":"Z Meyer","year":"2024","unstructured":"Meyer Z, Soukup ST, Lubs A et al (2024) Impact of dietary isoflavones in standard chow on reproductive development in juvenile and adult female mice with different metabolic phenotypes. Nutr 16:2697. https:\/\/doi.org\/10.3390\/NU16162697\/S1","journal-title":"Nutr"},{"key":"1891_CR96","doi-asserted-by":"publisher","first-page":"25","DOI":"10.3390\/NU16183084","volume":"16","author":"C Munekawa","year":"2024","unstructured":"Munekawa C, Okamura T, Majima S et al (2024) Daidzein inhibits muscle atrophy by suppressing inflammatory cytokine- and muscle atrophy-related gene expression. Nutrients 16:25. https:\/\/doi.org\/10.3390\/NU16183084","journal-title":"Nutrients"},{"key":"1891_CR97","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1016\/S1570-0232(02)00342-2","volume":"777","author":"PA Murphy","year":"2002","unstructured":"Murphy PA, Barua K, Hauck CC (2002) Solvent extraction selection in the determination of isoflavones in soy foods. J Chromatogr B 777:129\u2013138. https:\/\/doi.org\/10.1016\/S1570-0232(02)00342-2","journal-title":"J Chromatogr B"},{"key":"1891_CR98","doi-asserted-by":"publisher","DOI":"10.1007\/S12035-024-04567-W","author":"PV Nisha","year":"2024","unstructured":"Nisha PV (2024) Neuroprotective roles of daidzein through extracellular signal-regulated kinases dependent pathway in chronic unpredictable mild stress mouse model. Mol Neurobiol. https:\/\/doi.org\/10.1007\/S12035-024-04567-W","journal-title":"Mol Neurobiol"},{"key":"1891_CR99","doi-asserted-by":"publisher","first-page":"542","DOI":"10.1016\/J.FCT.2013.08.022","volume":"60","author":"HJ Park","year":"2013","unstructured":"Park HJ, Jeon YK, You DH, Nam MJ (2013) Daidzein causes cytochrome c-mediated apoptosis via the Bcl-2 family in human hepatic cancer cells. Food Chem Toxicol 60:542\u2013549. https:\/\/doi.org\/10.1016\/J.FCT.2013.08.022","journal-title":"Food Chem Toxicol"},{"key":"1891_CR100","doi-asserted-by":"publisher","first-page":"400","DOI":"10.1016\/J.YFRNE.2010.03.003","volume":"31","author":"HB Patisaul","year":"2010","unstructured":"Patisaul HB, Jefferson W (2010) The pros and cons of phytoestrogens. Front Neuroendocrinol 31:400. https:\/\/doi.org\/10.1016\/J.YFRNE.2010.03.003","journal-title":"Front Neuroendocrinol"},{"key":"1891_CR101","doi-asserted-by":"publisher","first-page":"7389","DOI":"10.3390\/IJMS25137389","volume":"25","author":"W Pa\u017adziora","year":"2024","unstructured":"Pa\u017adziora W, Pa\u015bko P, Grabowska K, Galanty A (2024) Can isoflavone-rich legume plants be useful in the chemoprevention of hormone-dependent cancers?\u2014A systematic review. Int J Mol Sci 25:7389. https:\/\/doi.org\/10.3390\/IJMS25137389","journal-title":"Int J Mol Sci"},{"key":"1891_CR102","doi-asserted-by":"publisher","first-page":"4213","DOI":"10.1021\/jf030174a","volume":"51","author":"JK Prasain","year":"2003","unstructured":"Prasain JK, Jones K, Kirk M et al (2003) Profiling and quantification of isoflavonoids in kudzu dietary supplements by high-performance liquid chromatography and electrospray ionization tandem mass spectrometry. J Agric Food Chem 51:4213\u20134218. https:\/\/doi.org\/10.1021\/jf030174a","journal-title":"J Agric Food Chem"},{"key":"1891_CR103","doi-asserted-by":"publisher","first-page":"739","DOI":"10.1016\/j.jnutbio.2007.10.002","volume":"19","author":"LE Pritchett","year":"2008","unstructured":"Pritchett LE, Atherton KM, Mutch E, Ford D (2008) Glucuronidation of the soyabean isoflavones genistein and daidzein by human liver is related to levels of UGT1A1 and UGT1A9 activity and alters isoflavone response in the MCF-7 human breast cancer cell line. J Nutr Biochem 19:739\u2013745. https:\/\/doi.org\/10.1016\/j.jnutbio.2007.10.002","journal-title":"J Nutr Biochem"},{"key":"1891_CR104","doi-asserted-by":"publisher","DOI":"10.1016\/j.jddst.2023.104278","volume":"81","author":"PS Priya","year":"2023","unstructured":"Priya PS, Vaishnavi S, Pavithra V et al (2023) Graphene oxide decorated daidzein as an oral drug to ameliorate the oxidative stress and glucocorticoid-induced osteoporosis in vivo zebrafish model. J Drug Deliv Sci Technol 81:104278. https:\/\/doi.org\/10.1016\/j.jddst.2023.104278","journal-title":"J Drug Deliv Sci Technol"},{"key":"1891_CR105","doi-asserted-by":"publisher","first-page":"603","DOI":"10.1007\/S13105-024-01046-7","volume":"80","author":"S Quesada-V\u00e1zquez","year":"2024","unstructured":"Quesada-V\u00e1zquez S, Eseberri I, Les F et al (2024) Polyphenols and metabolism: from present knowledge to future challenges. J Physiol Biochem 80:603. https:\/\/doi.org\/10.1007\/S13105-024-01046-7","journal-title":"J Physiol Biochem"},{"key":"1891_CR106","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1080\/01635589609514470;PAGE:STRING:ARTICLE\/CHAPTER","volume":"26","author":"K Reinli","year":"1996","unstructured":"Reinli K, Block G (1996) Phytoestrogen content of foods\u2014a compendium of literature values. Nutr Cancer 26:123\u2013148. https:\/\/doi.org\/10.1080\/01635589609514470;PAGE:STRING:ARTICLE\/CHAPTER","journal-title":"Nutr Cancer"},{"key":"1891_CR107","doi-asserted-by":"publisher","first-page":"7860","DOI":"10.1021\/JF801413Z","volume":"56","author":"A Reppert","year":"2008","unstructured":"Reppert A, Yousef GG, Rogers RB, Lila MA (2008) Isolation of radiolabeled isoflavones from kudzu (Pueraria lobata) root cultures. J Agric Food Chem 56:7860. https:\/\/doi.org\/10.1021\/JF801413Z","journal-title":"J Agric Food Chem"},{"key":"1891_CR108","doi-asserted-by":"publisher","first-page":"2123","DOI":"10.3390\/IJMS21062123","volume":"21","author":"J Ristori","year":"2020","unstructured":"Ristori J, Cocchetti C, Romani A et al (2020) Brain sex differences related to gender identity development: genes or hormones? Int J Mol Sci 21:2123. https:\/\/doi.org\/10.3390\/IJMS21062123","journal-title":"Int J Mol Sci"},{"key":"1891_CR109","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1016\/S0308-8146(02)00106-1","volume":"78","author":"MA Rostagno","year":"2002","unstructured":"Rostagno MA, Ara\u00fajo JMA, Sandi D (2002) Supercritical fluid extraction of isoflavones from soybean flour. Food Chem 78:111\u2013117. https:\/\/doi.org\/10.1016\/S0308-8146(02)00106-1","journal-title":"Food Chem"},{"key":"1891_CR110","doi-asserted-by":"crossref","unstructured":"Rungseevijitprapa W, Yingngam B, Chaiyasut C (2021) Improvement of biophysical skin parameters of topically applied fermented soybean extract-loaded niosomes with no systemic toxicity in ovariectomized rats. Pharmaceutics 13","DOI":"10.3390\/pharmaceutics13071068"},{"key":"1891_CR111","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2020.173763","author":"AAA Salama","year":"2021","unstructured":"Salama AAA, Allam RM (2021a) Promising targets of chrysin and daidzein in colorectal cancer: amphiregulin, CXCL1, and MMP-9. Eur J Pharmacol. https:\/\/doi.org\/10.1016\/j.ejphar.2020.173763","journal-title":"Eur J Pharmacol"},{"key":"1891_CR112","doi-asserted-by":"publisher","first-page":"173763","DOI":"10.1016\/j.ejphar.2020.173763","volume":"892","author":"AAA Salama","year":"2021","unstructured":"Salama AAA, Allam RM (2021b) Promising targets of chrysin and daidzein in colorectal cancer: amphiregulin, CXCL1, and MMP-9. Eur J Pharmacol 892:173763. https:\/\/doi.org\/10.1016\/j.ejphar.2020.173763","journal-title":"Eur J Pharmacol"},{"key":"1891_CR113","doi-asserted-by":"publisher","first-page":"17937","DOI":"10.18632\/ONCOTARGET.24788","volume":"9","author":"U Saqib","year":"2018","unstructured":"Saqib U, Sarkar S, Suk K et al (2018) Phytochemicals as modulators of M1\u2013M2 macrophages in inflammation. Oncotarget 9:17937\u201317950. https:\/\/doi.org\/10.18632\/ONCOTARGET.24788","journal-title":"Oncotarget"},{"key":"1891_CR114","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1016\/j.cbpc.2018.05.012","volume":"211","author":"C Sarasquete","year":"2018","unstructured":"Sarasquete C, \u00dabeda-Manzanaro M, Ortiz-Delgado JB (2018) Toxicity and non-harmful effects of the soya isoflavones, genistein and daidzein, in embryos of the zebrafish, Danio rerio. Comp Biochem Physiol Part C Toxicol Pharmacol 211:57\u201367. https:\/\/doi.org\/10.1016\/j.cbpc.2018.05.012","journal-title":"Comp Biochem Physiol Part C Toxicol Pharmacol"},{"key":"1891_CR115","doi-asserted-by":"publisher","first-page":"1363S","DOI":"10.3945\/jn.109.119784","volume":"140","author":"KDR Setchell","year":"2010","unstructured":"Setchell KDR, Clerici C (2010) Equol: pharmacokinetics and biological actions 1,2. J Nutr 140:1363S-1368S. https:\/\/doi.org\/10.3945\/jn.109.119784","journal-title":"J Nutr"},{"key":"1891_CR116","doi-asserted-by":"publisher","first-page":"3577","DOI":"10.1093\/jn\/132.12.3577","volume":"132","author":"KDR Setchell","year":"2002","unstructured":"Setchell KDR, Brown NM, Lydeking-Olsen E (2002) The clinical importance of the metabolite equol\u2014a clue to the effectiveness of soy and its isoflavones. J Nutr 132:3577\u20133584. https:\/\/doi.org\/10.1093\/jn\/132.12.3577","journal-title":"J Nutr"},{"key":"1891_CR117","doi-asserted-by":"publisher","first-page":"1284","DOI":"10.3945\/AJCN.111.019638","volume":"94","author":"KDR Setchell","year":"2011","unstructured":"Setchell KDR, Brown NM, Zhao X et al (2011) Soy isoflavone phase II metabolism differs between rodents and humans: implications for the effect on breast cancer risk1. Am J Clin Nutr 94:1284. https:\/\/doi.org\/10.3945\/AJCN.111.019638","journal-title":"Am J Clin Nutr"},{"key":"1891_CR118","doi-asserted-by":"publisher","first-page":"588","DOI":"10.1093\/ajcn\/76.3.588","volume":"76","author":"SR Shelnutt","year":"2002","unstructured":"Shelnutt SR, Cimino CO, Wiggins PA et al (2002) Pharmacokinetics of the glucuronide and sulfate conjugates of genistein and daidzein in men and women after consumption of a soy beverage123. Am J Clin Nutr 76:588\u2013594. https:\/\/doi.org\/10.1093\/ajcn\/76.3.588","journal-title":"Am J Clin Nutr"},{"key":"1891_CR119","doi-asserted-by":"publisher","first-page":"1044","DOI":"10.1208\/s12249-011-9672-4","volume":"12","author":"Q Shen","year":"2011","unstructured":"Shen Q, Li X, Li W, Zhao X (2011) Enhanced intestinal absorption of daidzein by borneol\/menthol eutectic mixture and microemulsion. AAPS PharmSciTech 12:1044\u20131049. https:\/\/doi.org\/10.1208\/s12249-011-9672-4","journal-title":"AAPS PharmSciTech"},{"key":"1891_CR120","doi-asserted-by":"publisher","first-page":"5153","DOI":"10.3390\/molecules15085153","volume":"15","author":"K Shimoda","year":"2010","unstructured":"Shimoda K, Hamada H (2010) Synthesis of \u03b2-maltooligosaccharides of glycitein and daidzein and their anti-oxidant and anti-allergic activities. Molecules 15:5153\u20135161. https:\/\/doi.org\/10.3390\/molecules15085153","journal-title":"Molecules"},{"key":"1891_CR121","doi-asserted-by":"publisher","first-page":"49","DOI":"10.3390\/BIOLOGY10010049","volume":"10","author":"H Silva","year":"2021","unstructured":"Silva H (2021) The vascular effects of isolated isoflavones\u2014a focus on the determinants of blood pressure regulation. Biology (Basel) 10:49. https:\/\/doi.org\/10.3390\/BIOLOGY10010049","journal-title":"Biology (Basel)"},{"key":"1891_CR122","doi-asserted-by":"publisher","DOI":"10.1007\/S00210-024-03356-5","author":"L Singh","year":"2024","unstructured":"Singh L (2024) Daidzein\u2019s potential in halting neurodegeneration: unveiling mechanistic insights. Naunyn Schmiedebergs Arch Pharmacol. https:\/\/doi.org\/10.1007\/S00210-024-03356-5","journal-title":"Naunyn Schmiedebergs Arch Pharmacol"},{"key":"1891_CR123","doi-asserted-by":"crossref","unstructured":"Singh S, Grewal S, Sharma N et al (2023) Unveiling the pharmacological and nanotechnological facets of daidzein: present state-of-the-art and future perspectives. Molecules 28","DOI":"10.3390\/molecules28041765"},{"key":"1891_CR124","doi-asserted-by":"publisher","DOI":"10.1016\/J.PRMCM.2024.100460","volume":"12","author":"N Singla","year":"2024","unstructured":"Singla N, Gupta G, Kulshrestha R et al (2024) Daidzein in traditional Chinese medicine: a deep dive into its Ethnomedicinal and therapeutic applications. Pharmacol Res Mod Chin Med 12:100460. https:\/\/doi.org\/10.1016\/J.PRMCM.2024.100460","journal-title":"Pharmacol Res Mod Chin Med"},{"key":"1891_CR125","doi-asserted-by":"publisher","first-page":"1609","DOI":"10.3390\/NU13051609","volume":"13","author":"W S\u0142upski","year":"2021","unstructured":"S\u0142upski W, Jawie\u0144 P, Nowak B (2021) Botanicals in postmenopausal osteoporosis. Nutrients 13:1609. https:\/\/doi.org\/10.3390\/NU13051609","journal-title":"Nutrients"},{"key":"1891_CR126","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2024.135662","volume":"280","author":"P Snega Priya","year":"2024","unstructured":"Snega Priya P, Surisetti R, Gopi S et al (2024) Chitosan-chondroitin sulfate-daidzein nanoconjugate ameliorates glucocorticoid induced osteoporosis in vivo. Int J Biol Macromol 280:135662. https:\/\/doi.org\/10.1016\/j.ijbiomac.2024.135662","journal-title":"Int J Biol Macromol"},{"key":"1891_CR127","doi-asserted-by":"publisher","first-page":"629","DOI":"10.1007\/BF00222458","volume":"89","author":"G Sonnante","year":"1994","unstructured":"Sonnante G, Stockton T, Nodari RO et al (1994) Evolution of genetic diversity during the domestication of common-bean (Phaseolus vulgaris L.). Theor Appl Genet 89:629\u2013635. https:\/\/doi.org\/10.1007\/BF00222458","journal-title":"Theor Appl Genet"},{"key":"1891_CR128","doi-asserted-by":"publisher","first-page":"719","DOI":"10.4330\/WJC.V7.I11.719","volume":"7","author":"JB Su","year":"2015","unstructured":"Su JB (2015) Vascular endothelial dysfunction and pharmacological treatment. World J Cardiol 7:719. https:\/\/doi.org\/10.4330\/WJC.V7.I11.719","journal-title":"World J Cardiol"},{"key":"1891_CR129","doi-asserted-by":"publisher","DOI":"10.3390\/NU9030207","author":"L Subedi","year":"2017","unstructured":"Subedi L, Ji E, Shin D et al (2017) Equol, a dietary daidzein gut metabolite attenuates microglial activation and potentiates neuroprotection in vitro. Nutrients. https:\/\/doi.org\/10.3390\/NU9030207","journal-title":"Nutrients"},{"key":"1891_CR130","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1016\/j.intimp.2016.08.014","volume":"40","author":"J Sun","year":"2016","unstructured":"Sun J, Sun WJ, Li ZY et al (2016) Daidzein increases OPG\/RANKL ratio and suppresses IL-6 in MG-63 osteoblast cells. Int Immunopharmacol 40:32\u201340. https:\/\/doi.org\/10.1016\/j.intimp.2016.08.014","journal-title":"Int Immunopharmacol"},{"key":"1891_CR131","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1016\/j.jsbmb.2018.04.004","volume":"181","author":"O Takaoka","year":"2018","unstructured":"Takaoka O, Mori T, Ito F et al (2018) Daidzein-rich isoflavone aglycones inhibit cell growth and inflammation in endometriosis. J Steroid Biochem Mol Biol 181:125\u2013132. https:\/\/doi.org\/10.1016\/j.jsbmb.2018.04.004","journal-title":"J Steroid Biochem Mol Biol"},{"key":"1891_CR132","doi-asserted-by":"publisher","DOI":"10.1016\/J.ABB.2024.109952","volume":"754","author":"B Thazhackavayal Baby","year":"2024","unstructured":"Thazhackavayal Baby B, Kulkarni AM, Gayam PKR et al (2024) Beyond cyclopamine: targeting hedgehog signaling for cancer intervention. Arch Biochem Biophys 754:109952. https:\/\/doi.org\/10.1016\/J.ABB.2024.109952","journal-title":"Arch Biochem Biophys"},{"key":"1891_CR133","doi-asserted-by":"publisher","first-page":"2435","DOI":"10.4314\/TJPR.V15I11.19","volume":"15","author":"D Tian","year":"2016","unstructured":"Tian D, Liu J, Liu N et al (2016) Daidzin decreases blood glucose and lipid in streptozotocin-induced diabetic mice. Trop J Pharm Res 15:2435\u20132443. https:\/\/doi.org\/10.4314\/TJPR.V15I11.19","journal-title":"Trop J Pharm Res"},{"key":"1891_CR134","doi-asserted-by":"publisher","first-page":"2055","DOI":"10.3390\/CELLS13242055","volume":"13","author":"M Traconis","year":"2024","unstructured":"Traconis M, Uribe-Esquivel AP, Becerra B et al (2024) Exploring the role of peroxisome proliferator-activated receptors and endothelial dysfunction in metabolic dysfunction-associated steatotic liver disease. Cells 13:2055. https:\/\/doi.org\/10.3390\/CELLS13242055","journal-title":"Cells"},{"key":"1891_CR135","doi-asserted-by":"publisher","first-page":"32271","DOI":"10.1021\/acsomega.3c03741","volume":"8","author":"M Ubaid","year":"2023","unstructured":"Ubaid M, Salauddin N, Shadani MA et al (2023) Daidzein from dietary supplement to a drug candidate: an evaluation of potential. ACS Omega 8:32271\u201332293. https:\/\/doi.org\/10.1021\/acsomega.3c03741","journal-title":"ACS Omega"},{"key":"1891_CR136","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1016\/j.jddst.2019.04.027","volume":"52","author":"AB Ugur Kaplan","year":"2019","unstructured":"Ugur Kaplan AB, Cetin M, Orgul D et al (2019) Formulation and in vitro evaluation of topical nanoemulsion and nanoemulsion-based gels containing daidzein. J Drug Deliv Sci Technol 52:189\u2013203. https:\/\/doi.org\/10.1016\/j.jddst.2019.04.027","journal-title":"J Drug Deliv Sci Technol"},{"key":"1891_CR137","doi-asserted-by":"publisher","first-page":"845","DOI":"10.1016\/J.JACBTS.2019.10.008","volume":"4","author":"GA Van Norman","year":"2019","unstructured":"Van Norman GA (2019) Limitations of animal studies for predicting toxicity in clinical trials: is it time to rethink our current approach? JACC Basic Transl Sci 4:845\u2013854. https:\/\/doi.org\/10.1016\/J.JACBTS.2019.10.008","journal-title":"JACC Basic Transl Sci"},{"key":"1891_CR138","doi-asserted-by":"publisher","first-page":"72","DOI":"10.7150\/ijms.4.72","volume":"4","author":"MT Velasquez","year":"2007","unstructured":"Velasquez MT, Bhathena SJ (2007) Role of dietary soy protein in obesity. Int J Med Sci 4:72\u201382. https:\/\/doi.org\/10.7150\/ijms.4.72","journal-title":"Int J Med Sci"},{"key":"1891_CR139","doi-asserted-by":"publisher","first-page":"256","DOI":"10.3390\/TOXICS12040256\/S1","volume":"12","author":"S Virtuoso","year":"2024","unstructured":"Virtuoso S, Raggi C, Maugliani A et al (2024) Toxicological effects of naturally occurring endocrine disruptors on various human health targets: a rapid review. Toxics 12:256. https:\/\/doi.org\/10.3390\/TOXICS12040256\/S1","journal-title":"Toxics"},{"key":"1891_CR140","doi-asserted-by":"publisher","DOI":"10.1016\/J.JFF.2022.105060","volume":"92","author":"X Wang","year":"2022","unstructured":"Wang X, Yin Z, Meng X et al (2022) Daidzein alleviates neuronal damage and oxidative stress via GSK3\u03b2\/Nrf2 pathway in mice. J Funct Foods 92:105060. https:\/\/doi.org\/10.1016\/J.JFF.2022.105060","journal-title":"J Funct Foods"},{"key":"1891_CR141","doi-asserted-by":"publisher","first-page":"230","DOI":"10.1016\/J.TJOG.2025.01.001","volume":"64","author":"PH Wang","year":"2025","unstructured":"Wang PH, Yang ST, Chang WH, Lee WL (2025) Menopause part I: vasomotor symptoms (I). Taiwan J Obstet Gynecol 64:230\u2013238. https:\/\/doi.org\/10.1016\/J.TJOG.2025.01.001","journal-title":"Taiwan J Obstet Gynecol"},{"key":"1891_CR142","doi-asserted-by":"publisher","DOI":"10.1088\/1742-6596\/1374\/1\/012052","author":"W Widowati","year":"2019","unstructured":"Widowati W, Prahastuti S, Ekayanti NLW et al (2019) Anti-inflammation assay of black soybean extract and its compounds on lipopolysaccharide-induced RAW 264.7 Cell. J Phys Conf Ser. https:\/\/doi.org\/10.1088\/1742-6596\/1374\/1\/012052","journal-title":"J Phys Conf Ser"},{"key":"1891_CR143","doi-asserted-by":"publisher","first-page":"23","DOI":"10.3390\/BIOM10010023","volume":"10","author":"MH Yang","year":"2019","unstructured":"Yang MH, Jung SH, Chinnathambi A et al (2019) Attenuation of STAT3 Signaling cascade by daidzin can enhance the apoptotic potential of bortezomib against multiple myeloma. Biomolecules 10:23. https:\/\/doi.org\/10.3390\/BIOM10010023","journal-title":"Biomolecules"},{"key":"1891_CR144","doi-asserted-by":"publisher","first-page":"1113789","DOI":"10.3389\/FNUT.2023.1113789\/FULL","volume":"10","author":"Z Yang","year":"2023","unstructured":"Yang Z, Gong D, He X et al (2023) Association between daidzein intake and metabolic associated fatty liver disease: a cross-sectional study from NHANES 2017\u20132018. Front Nutr 10:1113789. https:\/\/doi.org\/10.3389\/FNUT.2023.1113789\/FULL","journal-title":"Front Nutr"},{"key":"1891_CR145","doi-asserted-by":"publisher","first-page":"2713","DOI":"10.1016\/j.fct.2008.04.026","volume":"46","author":"S Yee","year":"2008","unstructured":"Yee S, Burdock GA, Kurata Y et al (2008) Acute and subchronic toxicity and genotoxicity of SE5-OH, an equol-rich product produced by Lactococcus garvieae. Food Chem Toxicol 46:2713\u20132720. https:\/\/doi.org\/10.1016\/j.fct.2008.04.026","journal-title":"Food Chem Toxicol"},{"key":"1891_CR146","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1016\/j.molimm.2014.04.006","volume":"60","author":"JH Yen","year":"2014","unstructured":"Yen JH, Yang DJ, Chen MC et al (2014) Daidzein enhances efferocytosis via transglutaminase 2 and augmentation of Rac1 activity. Mol Immunol 60:135\u2013142. https:\/\/doi.org\/10.1016\/j.molimm.2014.04.006","journal-title":"Mol Immunol"},{"key":"1891_CR147","doi-asserted-by":"publisher","first-page":"1193","DOI":"10.1016\/j.jnutbio.2015.05.010","volume":"26","author":"M Yoshino","year":"2015","unstructured":"Yoshino M, Naka A, Sakamoto Y et al (2015) Dietary isoflavone daidzein promotes Tfam expression that increases mitochondrial biogenesis in C2C12 muscle cells. J Nutr Biochem 26:1193\u20131199. https:\/\/doi.org\/10.1016\/j.jnutbio.2015.05.010","journal-title":"J Nutr Biochem"},{"key":"1891_CR148","doi-asserted-by":"publisher","first-page":"389","DOI":"10.1093\/JN\/133.2.389","volume":"133","author":"L Yu","year":"2003","unstructured":"Yu L, Blackburn GL, Zhou JR (2003) Genistein and daidzein downregulate prostate androgen-regulated transcript-1 (PART-1) gene expression induced by dihydrotestosterone in human prostate LNCaP cancer cells. J Nutr 133:389\u2013392. https:\/\/doi.org\/10.1093\/JN\/133.2.389","journal-title":"J Nutr"},{"key":"1891_CR149","doi-asserted-by":"publisher","first-page":"688","DOI":"10.1038\/MP.2014.10","volume":"19","author":"Q Yu","year":"2014","unstructured":"Yu Q, Teixeira CM, Mahadevia D et al (2014) Dopamine and serotonin signaling during two sensitive developmental periods differentially impact adult aggressive and affective behaviors in mice. Mol Psychiatry 19:688. https:\/\/doi.org\/10.1038\/MP.2014.10","journal-title":"Mol Psychiatry"},{"key":"1891_CR150","doi-asserted-by":"publisher","DOI":"10.1016\/J.EJPHAR.2020.173399","volume":"885","author":"Z Yu","year":"2020","unstructured":"Yu Z, Yang L, Deng S, Liang M (2020) Daidzein ameliorates LPS-induced hepatocyte injury by inhibiting inflammation and oxidative stress. Eur J Pharmacol 885:173399. https:\/\/doi.org\/10.1016\/J.EJPHAR.2020.173399","journal-title":"Eur J Pharmacol"},{"key":"1891_CR151","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1177\/09731296221137378","volume":"19","author":"J Zhang","year":"2023","unstructured":"Zhang J, Kowsalya R (2023) Daidzein ameliorates cerebral ischemic-reperfusion induced neuroinflammation in wistar rats via inhibiting NF-\u03baB signaling pathway. Pharmacogn Mag 19:85\u201396. https:\/\/doi.org\/10.1177\/09731296221137378","journal-title":"Pharmacogn Mag"},{"key":"1891_CR152","doi-asserted-by":"publisher","first-page":"1365","DOI":"10.2217\/nnm.11.39","volume":"6","author":"Z Zhang","year":"2011","unstructured":"Zhang Z, Yan H, Fang G et al (2011) A self-assembled nanodelivery system enhances the oral bioavailability of daidzein. In vitro characteristics and in vivo performance. Nanomedicine 6:1365\u20131379. https:\/\/doi.org\/10.2217\/nnm.11.39","journal-title":"Nanomedicine"},{"key":"1891_CR153","doi-asserted-by":"publisher","first-page":"4878","DOI":"10.3892\/etm.2017.5166","volume":"14","author":"F Zhang","year":"2017","unstructured":"Zhang F, Ru N, Shang Z et al (2017) Daidzein ameliorates spinal cord ischemia\/reperfusion injury-induced neurological function deficits in Sprague\u2013Dawley rats through PI3K\/Akt signaling pathway. Exp Ther Med 14:4878\u20134886. https:\/\/doi.org\/10.3892\/etm.2017.5166","journal-title":"Exp Ther Med"},{"key":"1891_CR154","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1186\/S12974-018-1246-X","volume":"15","author":"Z Zhang","year":"2018","unstructured":"Zhang Z, Qin P, Deng Y et al (2018) The novel estrogenic receptor GPR30 alleviates ischemic injury by inhibiting TLR4-mediated microglial inflammation. J Neuroinflammation 15:25. https:\/\/doi.org\/10.1186\/S12974-018-1246-X","journal-title":"J Neuroinflammation"},{"key":"1891_CR155","doi-asserted-by":"publisher","first-page":"4363","DOI":"10.1002\/PTR.7132","volume":"35","author":"H Zhang","year":"2021","unstructured":"Zhang H, Chi M, Chen L et al (2021a) Daidzein alleviates cisplatin-induced muscle atrophy by regulating Glut4\/AMPK\/FoxO pathway. Phyther Res 35:4363\u20134376. https:\/\/doi.org\/10.1002\/PTR.7132","journal-title":"Phyther Res"},{"key":"1891_CR156","doi-asserted-by":"publisher","first-page":"3739","DOI":"10.3390\/NU13113739","volume":"13","author":"X Zhang","year":"2021","unstructured":"Zhang X, Veliky CV, Birru RL et al (2021b) Potential protective effects of equol (soy isoflavone metabolite) on coronary heart diseases\u2014from molecular mechanisms to studies in humans. Nutrients 13:3739. https:\/\/doi.org\/10.3390\/NU13113739","journal-title":"Nutrients"},{"key":"1891_CR157","doi-asserted-by":"publisher","first-page":"e7","DOI":"10.1111\/AJD.12126","volume":"56","author":"D Zhao","year":"2015","unstructured":"Zhao D, Shi Y, Dang Y et al (2015) Daidzein stimulates collagen synthesis by activating the TGF-\u03b2\/smad signal pathway. Australas J Dermatol 56:e7\u2013e14. https:\/\/doi.org\/10.1111\/AJD.12126","journal-title":"Australas J Dermatol"},{"key":"1891_CR158","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1038\/S41392-021-00658-5","volume":"6","author":"H Zhao","year":"2021","unstructured":"Zhao H, Wu L, Yan G et al (2021) Inflammation and tumor progression: signaling pathways and targeted intervention. Signal Transduct Target Ther 6:263. https:\/\/doi.org\/10.1038\/S41392-021-00658-5","journal-title":"Signal Transduct Target Ther"},{"key":"1891_CR159","doi-asserted-by":"publisher","DOI":"10.3389\/FPHAR.2021.772485","volume":"12","author":"M Zheng","year":"2022","unstructured":"Zheng M, Zhou M, Chen M et al (2022) Neuroprotective effect of daidzein extracted from pueraria lobate radix in a stroke model via the Akt\/mTOR\/BDNF channel. Front Pharmacol 12:772485. https:\/\/doi.org\/10.3389\/FPHAR.2021.772485","journal-title":"Front Pharmacol"}],"container-title":["Inflammopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10787-025-01891-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10787-025-01891-y\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10787-025-01891-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,17]],"date-time":"2025-09-17T04:14:26Z","timestamp":1758082466000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10787-025-01891-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8,20]]},"references-count":159,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2025,9]]}},"alternative-id":["1891"],"URL":"https:\/\/doi.org\/10.1007\/s10787-025-01891-y","relation":{},"ISSN":["0925-4692","1568-5608"],"issn-type":[{"value":"0925-4692","type":"print"},{"value":"1568-5608","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,8,20]]},"assertion":[{"value":"17 April 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 July 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 August 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors have declared that there is no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}