{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T15:19:26Z","timestamp":1785338366373,"version":"3.55.0"},"reference-count":50,"publisher":"Springer Science and Business Media LLC","issue":"8","license":[{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Inflammopharmacol"],"published-print":{"date-parts":[[2025,8]]},"DOI":"10.1007\/s10787-025-01896-7","type":"journal-article","created":{"date-parts":[[2025,8,12]],"date-time":"2025-08-12T12:51:43Z","timestamp":1755003103000},"page":"4629-4649","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Therapeutic efficacy of celastrol in experimental polyarthritis: insights from a meta-analysis of in vivo studies"],"prefix":"10.1007","volume":"33","author":[{"given":"Muhammad Muzammil","family":"Nazir","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iqra","family":"Farzeen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7026-670X","authenticated-orcid":false,"given":"Asma","family":"Ashraf","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,8,12]]},"reference":[{"key":"1896_CR1","doi-asserted-by":"crossref","unstructured":"Ali M, Wani SUD, Salahuddin M, Dey T, Zargar MI, Singh J (2023) Recent advance of herbal medicines in cancer-a molecular approach. Heliyon 9(2)","DOI":"10.1016\/j.heliyon.2023.e13684"},{"issue":"10","key":"1896_CR2","doi-asserted-by":"publisher","first-page":"7728","DOI":"10.1021\/acs.nanolett.0c03279","volume":"20","author":"L An","year":"2020","unstructured":"An L, Li Z, Shi L, Wang L, Wang Y, Jin L, Shuai X, Li J (2020) Inflammation-targeted celastrol nanodrug attenuates collagen-induced arthritis through NF-\u03baB and Notch1 pathways. Nano Lett 20(10):7728\u20137736","journal-title":"Nano Lett"},{"issue":"2","key":"1896_CR3","doi-asserted-by":"publisher","first-page":"228","DOI":"10.1016\/j.clim.2015.01.011","volume":"157","author":"B Astry","year":"2015","unstructured":"Astry B, Venkatesha SH, Laurence A, Christensen-Quick A, Garzino-Demo A, Frieman MB, O\u2019Shea JJ, Moudgil KD (2015) Celastrol, a Chinese herbal compound, controls autoimmune inflammation by altering the balance of pathogenic and regulatory T cells in the target organ. Clin Immunol 157(2):228\u2013238","journal-title":"Clin Immunol"},{"issue":"12","key":"1896_CR4","doi-asserted-by":"publisher","first-page":"856","DOI":"10.1016\/j.autrev.2012.02.022","volume":"11","author":"R Cascao","year":"2012","unstructured":"Cascao R, Vidal B, Raquel H, Neves-Costa A, Figueiredo N, Gupta V, Fonseca J, Moita L (2012) Effective treatment of rat adjuvant-induced arthritis by celastrol. Autoimmun Rev 11(12):856\u2013862","journal-title":"Autoimmun Rev"},{"issue":"12","key":"1896_CR5","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0142448","volume":"10","author":"R Casc\u00e3o","year":"2015","unstructured":"Casc\u00e3o R, Vidal B, Lopes IP, Paisana E, Rino J, Moita LF, Fonseca JE (2015) Decrease of CD68 synovial macrophages in celastrol treated arthritic rats. PLoS ONE 10(12):e0142448","journal-title":"PLoS ONE"},{"issue":"2","key":"1896_CR6","doi-asserted-by":"publisher","DOI":"10.1136\/rmdopen-2017-000438","volume":"3","author":"R Casc\u00e3o","year":"2017","unstructured":"Casc\u00e3o R, Vidal B, Finnil\u00e4 MAJ, Lopes IP, Teixeira RL, Saarakkala S, Moita LF, Fonseca JE (2017) Effect of celastrol on bone structure and mechanics in arthritic rats. RMD Open 3(2):e000438","journal-title":"RMD Open"},{"key":"1896_CR7","doi-asserted-by":"publisher","first-page":"455","DOI":"10.3389\/fmed.2020.00455","volume":"7","author":"R Casc\u00e3o","year":"2020","unstructured":"Casc\u00e3o R, Vidal B, Carvalho T, Lopes IP, Rom\u00e3o VC, Goncalves J, Moita LF, Fonseca JE (2020) Celastrol efficacy by oral administration in the adjuvant-induced arthritis model. Front Med 7:455","journal-title":"Front Med"},{"key":"1896_CR8","doi-asserted-by":"crossref","unstructured":"Chauhan P, Pandey P, Ramniwas S, Verma M, Ganeshan S, Rajotiya S., Devi S, Lakhanpal S, Kumar MR, Pandey S (2025) Unveiling the anticancer potential of phytocompounds: pioneering future cancer therapies. Curr Top Med Chem","DOI":"10.2174\/0115680266354680250121154720"},{"key":"1896_CR9","doi-asserted-by":"publisher","first-page":"104","DOI":"10.3389\/fphar.2018.00104","volume":"9","author":"S-R Chen","year":"2018","unstructured":"Chen S-R, Dai Y, Zhao J, Lin L, Wang Y, Wang Y (2018) A mechanistic overview of triptolide and celastrol, natural products from Tripterygium wilfordii Hook F. Front Pharmacol 9:104","journal-title":"Front Pharmacol"},{"issue":"10","key":"1896_CR10","first-page":"591","volume":"18","author":"A Finckh","year":"2022","unstructured":"Finckh A, Gilbert B, Hodkinson B, Bae S-C, Thomas R, Deane KD, Alpizar-Rodriguez D, Lauper K (2022) Global epidemiology of rheumatoid arthritis. Nat Rev Rheumatol 18(10):591\u2013602","journal-title":"Nat Rev Rheumatol"},{"issue":"2","key":"1896_CR11","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1016\/j.intimp.2014.12.012","volume":"24","author":"K Gan","year":"2015","unstructured":"Gan K, Xu L, Feng X, Zhang Q, Wang F, Zhang M, Tan W (2015) Celastrol attenuates bone erosion in collagen-Induced arthritis mice and inhibits osteoclast differentiation and function in RANKL-induced RAW2647. Int Immunopharmacol 24(2):239\u2013246","journal-title":"Int Immunopharmacol"},{"key":"1896_CR12","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2020.106527","volume":"84","author":"Q Gao","year":"2020","unstructured":"Gao Q, Qin H, Zhu L, Li D, Hao X (2020) Celastrol attenuates collagen-induced arthritis via inhibiting oxidative stress in rats. Int Immunopharmacol 84:106527","journal-title":"Int Immunopharmacol"},{"issue":"10","key":"1896_CR13","doi-asserted-by":"publisher","first-page":"1849","DOI":"10.1007\/s00296-024-05639-9","volume":"44","author":"CW Hansen","year":"2024","unstructured":"Hansen CW, N\u00f8rgaard MW, de Thurah A, Midtgaard J, Cromhout PF, Esbensen BA (2024) Significant others in inflammatory arthritis: roles, influences, and challenges\u2014a scoping review. Rheumatol Int 44(10):1849\u20131859","journal-title":"Rheumatol Int"},{"key":"1896_CR14","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2020.112081","volume":"189","author":"W Hou","year":"2020","unstructured":"Hou W, Liu B, Xu H (2020) Celastrol: progresses in structure-modifications, structure-activity relationships, pharmacology and toxicology. Eur J Med Chem 189:112081","journal-title":"Eur J Med Chem"},{"key":"1896_CR15","first-page":"83","volume":"36","author":"P Hua","year":"2024","unstructured":"Hua P, Liang R, Yang S, Tu Y, Chen M (2024) Microneedle-assisted dual delivery of PUMA gene and celastrol for synergistic therapy of rheumatoid arthritis through restoring synovial homeostasis. Bioact Mater 36:83\u201395","journal-title":"Bioact Mater"},{"key":"1896_CR16","doi-asserted-by":"crossref","unstructured":"Iqbal U, Malik A, Ibrahim L, Sial NT, Mehmood MH (2025) Natural and synthetic potential drug leads for rheumatoid arthritis probing innovative target: mitochondrial dysfunction and NLRP3 inflammasome activation. Naunyn-Schmiedeberg's Arch Pharmacol, pp 1\u201318","DOI":"10.1007\/s00210-025-03897-3"},{"key":"1896_CR17","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2021.107879","volume":"98","author":"M Jing","year":"2021","unstructured":"Jing M, Yang J, Zhang L, Liu J, Xu S, Wang M, Zhang L, Sun Y, Yan W, Hou G (2021) Celastrol inhibits rheumatoid arthritis through the ROS-NF-\u03baB-NLRP3 inflammasome axis. Int Immunopharmacol 98:107879","journal-title":"Int Immunopharmacol"},{"issue":"11","key":"1896_CR18","doi-asserted-by":"publisher","first-page":"2967","DOI":"10.1007\/s10067-019-04684-1","volume":"38","author":"KJ Johnson","year":"2019","unstructured":"Johnson KJ, Sanchez HN, Schoenbrunner N (2019) Defining response to TNF-inhibitors in rheumatoid arthritis: the negative impact of anti-TNF cycling and the need for a personalized medicine approach to identify primary non-responders. Clin Rheumatol 38(11):2967\u20132976","journal-title":"Clin Rheumatol"},{"key":"1896_CR19","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1186\/s42358-024-00403-w","volume":"64","author":"AM Kakehasi","year":"2024","unstructured":"Kakehasi AM, Duarte ALBP, Brenol CV, Domiciano DS, Laurindo IMM, Bonfiglioli KR, Mota LMH, Buch MH, Mac\u00eado EA, Xavier RM (2024) Challenges in implementing treat-to-target in rheumatoid arthritis: a perspective from Brazilian rheumatologists. Adv Rheumatol 64:63","journal-title":"Adv Rheumatol"},{"key":"1896_CR20","doi-asserted-by":"publisher","DOI":"10.1016\/j.matdes.2022.111298","volume":"224","author":"S Lin","year":"2022","unstructured":"Lin S, Wang D, Xu C, Zhang P, Gao K, Liu C, Mei X (2022) Therapy of rheumatoid arthritis by reactive oxygen species-responsive celastrol-loaded nanomedicines via targeting macrophages apoptosis. Mater des 224:111298","journal-title":"Mater des"},{"issue":"9","key":"1896_CR21","doi-asserted-by":"publisher","first-page":"5103","DOI":"10.1002\/ptr.7138","volume":"35","author":"R Marahatha","year":"2021","unstructured":"Marahatha R, Gyawali K, Sharma K, Gyawali N, Tandan P, Adhikari A, Timilsina G, Bhattarai S, Lamichhane G, Acharya A (2021) Pharmacologic activities of phytosteroids in inflammatory diseases: Mechanism of action and therapeutic potentials. Phytother Res 35(9):5103\u20135124","journal-title":"Phytother Res"},{"issue":"10","key":"1896_CR22","doi-asserted-by":"publisher","first-page":"2311","DOI":"10.1007\/s00210-023-02517-2","volume":"396","author":"SS Mohanty","year":"2023","unstructured":"Mohanty SS, Sahoo CR, Paidesetty SK, Padhy RN (2023) Role of phytocompounds as the potential anti-viral agent: an overview. Naunyn Schmiedebergs Arch Pharmacol 396(10):2311\u20132329","journal-title":"Naunyn Schmiedebergs Arch Pharmacol"},{"issue":"26","key":"1896_CR23","doi-asserted-by":"publisher","first-page":"22216","DOI":"10.1074\/jbc.M112.356816","volume":"287","author":"SM Nanjundaiah","year":"2012","unstructured":"Nanjundaiah SM, Venkatesha SH, Yu H, Tong L, Stains JP, Moudgil KD (2012) Celastrus and its bioactive celastrol protect against bone damage in autoimmune arthritis by modulating osteoimmune cross-talk. J Biol Chem 287(26):22216\u201322226","journal-title":"J Biol Chem"},{"key":"1896_CR24","doi-asserted-by":"crossref","unstructured":"Nazir MM, Farzeen I, Fasial S, Ashraf A (2024) Berberine in rheumatoid arthritis: a comprehensive review and meta-analysis of its anti-inflammatory and immunomodulatory mechanisms in animal models. Inflammopharmacology pp 1\u201315","DOI":"10.1007\/s10787-024-01612-x"},{"key":"1896_CR25","first-page":"e934475","volume":"27","author":"DV Parums","year":"2021","unstructured":"Parums DV (2021) Review articles, systematic reviews, meta-analysis, and the updated preferred reporting items for systematic reviews and meta-analyses (PRISMA) 2020 guidelines. Med Sci Monitor Int Med J Exp Clin Res 27:e934475\u2013e934471","journal-title":"Med Sci Monitor Int Med J Exp Clin Res"},{"issue":"1","key":"1896_CR26","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1007\/s11010-022-04492-3","volume":"478","author":"P Prasad","year":"2023","unstructured":"Prasad P, Verma S, Surbhi X, Ganguly NK, Chaturvedi V, Mittal SA (2023) Rheumatoid arthritis: advances in treatment strategies. Mole Cell Biochem 478(1):69\u201388","journal-title":"Mole Cell Biochem"},{"issue":"11","key":"1896_CR27","doi-asserted-by":"publisher","first-page":"2857","DOI":"10.3390\/cells10112857","volume":"10","author":"A-F Radu","year":"2021","unstructured":"Radu A-F, Bungau SG (2021) Management of rheumatoid arthritis: an overview. Cells 10(11):2857","journal-title":"Cells"},{"issue":"4","key":"1896_CR28","doi-asserted-by":"publisher","DOI":"10.1002\/bmm2.12104","volume":"2","author":"H Ren","year":"2024","unstructured":"Ren H, Wu Z, Li J, Zhang N, Nah CY, Li J, Zhang J, Lovell JF, Zhang L, Zhang Y (2024) A biomimetic, triggered-release micelle formulation of methotrexate and celastrol controls collagen-induced arthritis in mice. Bmemat 2(4):e12104","journal-title":"Bmemat"},{"issue":"6","key":"1896_CR29","doi-asserted-by":"publisher","first-page":"2500","DOI":"10.1002\/fsn3.3308","volume":"11","author":"M Riaz","year":"2023","unstructured":"Riaz M, Khalid R, Afzal M, Anjum F, Fatima H, Zia S, Rasool G, Egbuna C, Mtewa AG, Uche CZ (2023) Phytobioactive compounds as therapeutic agents for human diseases: a review. Food Sci Nutr 11(6):2500\u20132529","journal-title":"Food Sci Nutr"},{"key":"1896_CR30","doi-asserted-by":"publisher","DOI":"10.1016\/j.jddst.2023.105185","volume":"91","author":"J Si","year":"2024","unstructured":"Si J, Guo R, Zhang L, Liu W, Kong L, Liu Y, Yu Y, Zang J, Chen W, Li X (2024) Mannose-modified celastrol liposomes targeted activated macrophages for rheumatoid arthritis treatment in vitro and in vivo evaluation. J Drug Deliv Sci Technol 91:105185","journal-title":"J Drug Deliv Sci Technol"},{"key":"1896_CR31","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2023.114705","volume":"162","author":"J Song","year":"2023","unstructured":"Song J, He G-N, Dai L (2023) A comprehensive review on celastrol, triptolide and triptonide: Insights on their pharmacological activity, toxicity, combination therapy, new dosage form and novel drug delivery routes. Biomed Pharmacother 162:114705","journal-title":"Biomed Pharmacother"},{"key":"1896_CR32","doi-asserted-by":"crossref","unstructured":"Sparks, J. A. (2019). Rheumatoid arthritis. Annals of Internal Medicine-In the Clinic, 170(1), ITC1-ITC16e16.","DOI":"10.7326\/AITC201901010"},{"issue":"1","key":"1896_CR33","doi-asserted-by":"publisher","first-page":"318","DOI":"10.1186\/s12951-025-03389-9","volume":"23","author":"Y Su","year":"2025","unstructured":"Su Y, Chen R, Wang B, Wang T, Tao J, Diao Q, Jiang T, Zhao X (2025) Erythrocyte membrane camouflaged celastrol and bilirubin self-assembly for rheumatoid arthritis immunotherapy based on STING inhibition and RONS clearance. J Nanobiotechnol 23(1):318","journal-title":"J Nanobiotechnol"},{"issue":"17","key":"1896_CR34","doi-asserted-by":"publisher","first-page":"15138","DOI":"10.1074\/jbc.M111.226365","volume":"286","author":"SH Venkatesha","year":"2011","unstructured":"Venkatesha SH, Yu H, Rajaiah R, Tong L, Moudgil KD (2011) Celastrus-derived celastrol suppresses autoimmune arthritis by modulating antigen-induced cellular and humoral effector responses. J Biol Chem 286(17):15138\u201315146","journal-title":"J Biol Chem"},{"issue":"17","key":"1896_CR35","doi-asserted-by":"publisher","first-page":"5229","DOI":"10.1016\/j.bmc.2012.06.050","volume":"20","author":"SH Venkatesha","year":"2012","unstructured":"Venkatesha SH, Astry B, Nanjundaiah SM, Yu H, Moudgil KD (2012) Suppression of autoimmune arthritis by Celastrus-derived Celastrol through modulation of pro-inflammatory chemokines. Bioorg Med Chem 20(17):5229\u20135234","journal-title":"Bioorg Med Chem"},{"key":"1896_CR36","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2024.111822","volume":"131","author":"B Wang","year":"2024","unstructured":"Wang B, Shen J, Wang X, Hou R (2024) Biomimetic nanoparticles for effective Celastrol delivery to targeted treatment of rheumatoid arthritis through the ROS-NF-\u03baB inflammasome axis. Int Immunopharmacol 131:111822","journal-title":"Int Immunopharmacol"},{"issue":"16","key":"1896_CR37","doi-asserted-by":"publisher","first-page":"2922","DOI":"10.1111\/bph.14718","volume":"176","author":"VKW Wong","year":"2019","unstructured":"Wong VKW, Qiu C, Xu SW, Law BYK, Zeng W, Wang H, Michelangeli F, Dias IRDSR, Qu YQ, Chan TW (2019) Ca2+ signalling plays a role in celastrol-mediated suppression of synovial fibroblasts of rheumatoid arthritis patients and experimental arthritis in rats. Br J Pharmacol 176(16):2922\u20132944","journal-title":"Br J Pharmacol"},{"issue":"5","key":"1896_CR38","first-page":"4753","volume":"18","author":"J Xi","year":"2018","unstructured":"Xi J, Li Q, Luo X, Wang Y, Li J, Guo L, Wu G (2018) Celastrol inhibits glucocorticoid-induced osteoporosis in rat via the PI3K\/AKT and Wnt signaling pathways. Mol Med Rep 18(5):4753\u20134759","journal-title":"Mol Med Rep"},{"issue":"1","key":"1896_CR39","doi-asserted-by":"publisher","DOI":"10.1136\/lupus-2023-001057","volume":"11","author":"T Xie","year":"2024","unstructured":"Xie T, Rui H, Liu H, Liu X, Liu X, Li P (2024) Celastrol ameliorates lupus by promoting apoptosis of autoimmune T cells and preventing autoimmune response in MRL\/lpr mice. Lupus Sci Med 11(1):e001057","journal-title":"Lupus Sci Med"},{"key":"1896_CR40","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2021.105572","volume":"167","author":"S Xu","year":"2021","unstructured":"Xu S, Feng Y, He W, Xu W, Xu W, Yang H, Li X (2021) Celastrol in metabolic diseases: Progress and application prospects. Pharmacol Res 167:105572","journal-title":"Pharmacol Res"},{"key":"1896_CR41","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2020.153398","volume":"80","author":"C-Y Yan","year":"2021","unstructured":"Yan C-Y, Ouyang S-H, Wang X, Wu Y-P, Sun W-Y, Duan W-J, Liang L, Luo X, Kurihara H, Li Y-F (2021) Celastrol ameliorates Propionibacterium acnes\/LPS-induced liver damage and MSU-induced gouty arthritis via inhibiting K63 deubiquitination of NLRP3. Phytomedicine 80:153398","journal-title":"Phytomedicine"},{"key":"1896_CR42","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2022.109241","volume":"112","author":"J Yang","year":"2022","unstructured":"Yang J, Liu J, Li J, Jing M, Zhang L, Sun M, Wang Q, Sun H, Hou G, Wang C (2022) Celastrol inhibits rheumatoid arthritis by inducing autophagy via inhibition of the PI3K\/AKT\/mTOR signaling pathway. Int Immunopharmacol 112:109241","journal-title":"Int Immunopharmacol"},{"issue":"1","key":"1896_CR43","doi-asserted-by":"publisher","first-page":"346","DOI":"10.1007\/s10753-024-02060-z","volume":"48","author":"J Yang","year":"2025","unstructured":"Yang J, He B, Dang L, Liu J, Liu G, Zhao Y, Yu P, Wang Q, Wang L, Xin W (2025) Celastrol regulates the hsp90-NLRP3 interaction to alleviate rheumatoid arthritis. Inflammation 48(1):346\u2013360","journal-title":"Inflammation"},{"issue":"8","key":"1896_CR44","doi-asserted-by":"publisher","first-page":"1007","DOI":"10.1161\/CIRCRESAHA.119.315861","volume":"126","author":"S Ye","year":"2020","unstructured":"Ye S, Luo W, Khan ZA, Wu G, Xuan L, Shan P, Lin K, Chen T, Wang J, Hu X (2020) Celastrol attenuates angiotensin II\u2013induced cardiac remodeling by targeting STAT3. Circ Res 126(8):1007\u20131023","journal-title":"Circ Res"},{"issue":"1","key":"1896_CR45","first-page":"50","volume":"4","author":"K Yuan","year":"2017","unstructured":"Yuan K, Huang G, Zhang S, Zhu Q, Yu R, Sheng H, Luo G, Xu A (2017) Celastrol alleviates arthritis by modulating the inflammatory activities of neutrophils. J Tradition Chinese Med Sci 4(1):50\u201358","journal-title":"J Tradition Chinese Med Sci"},{"issue":"1","key":"1896_CR46","doi-asserted-by":"publisher","first-page":"1604","DOI":"10.1038\/s41598-023-48248-5","volume":"14","author":"L Zeng","year":"2024","unstructured":"Zeng L, Yu G, Yang K, He Q, Hao W, Xiang W, Long Z, Chen H, Tang X, Sun L (2024) Exploring the mechanism of Celastrol in the treatment of rheumatoid arthritis based on systems pharmacology and multi-omics. Sci Rep 14(1):1604","journal-title":"Sci Rep"},{"issue":"1","key":"1896_CR47","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1016\/j.jep.2012.09.005","volume":"144","author":"J Zhang","year":"2012","unstructured":"Zhang J, Li C-Y, Xu M-J, Wu T, Chu J-H, Liu S-J, Ju W-Z (2012) Oral bioavailability and gender-related pharmacokinetics of celastrol following administration of pure celastrol and its related tablets in rats. J Ethnopharmacol 144(1):195\u2013200","journal-title":"J Ethnopharmacol"},{"issue":"6","key":"1896_CR48","doi-asserted-by":"publisher","first-page":"1222","DOI":"10.1002\/jssc.202100807","volume":"45","author":"X Zhang","year":"2022","unstructured":"Zhang X, Chen Y, Feng X, Li L, Song K, Sun Y, Zhang G, Zhang L (2022) A comprehensive study of celastrol metabolism in vivo and in vitro using ultra-high-performance liquid chromatography coupled with hybrid triple quadrupole time-of-flight mass spectrometry. J Separat Sci 45(6):1222\u20131239","journal-title":"J Separat Sci"},{"issue":"1","key":"1896_CR49","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12951-024-02937-z","volume":"23","author":"X Zhang","year":"2025","unstructured":"Zhang X, Fu X, Chen W, Chen P, Zhu H, Yang B, Liang J, Zeng F (2025) Amelioration of the rheumatoid arthritis microenvironment using celastrol-loaded silver-modified ceria nanoparticles for enhanced treatment. J Nanobiotechnol 23(1):1\u201317","journal-title":"J Nanobiotechnol"},{"key":"1896_CR50","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1208\/s12248-021-00655-0","volume":"24","author":"X Zhao","year":"2022","unstructured":"Zhao X, Huang C, Su M, Ran Y, Wang Y, Yin Z (2022) Reactive oxygen species-responsive celastrol-loaded: bilirubin nanoparticles for the treatment of rheumatoid arthritis. AAPS J 24:1\u201313","journal-title":"AAPS J"}],"container-title":["Inflammopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10787-025-01896-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10787-025-01896-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10787-025-01896-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,9]],"date-time":"2025-09-09T01:06:39Z","timestamp":1757379999000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10787-025-01896-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8]]},"references-count":50,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2025,8]]}},"alternative-id":["1896"],"URL":"https:\/\/doi.org\/10.1007\/s10787-025-01896-7","relation":{},"ISSN":["0925-4692","1568-5608"],"issn-type":[{"value":"0925-4692","type":"print"},{"value":"1568-5608","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,8]]},"assertion":[{"value":"24 July 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 July 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 August 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"There is no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}