{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T11:25:43Z","timestamp":1793273143792,"version":"4.5.0"},"reference-count":57,"publisher":"Springer Science and Business Media LLC","issue":"9","license":[{"start":{"date-parts":[[2025,8,12]],"date-time":"2025-08-12T00:00:00Z","timestamp":1754956800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,8,12]],"date-time":"2025-08-12T00:00:00Z","timestamp":1754956800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"name":"The Jilin Province Science and Technology Development Plan","award":["20240602086RC"],"award-info":[{"award-number":["20240602086RC"]}]},{"name":"The Jilin Province Science and Technology Development Plan","award":["YDZJ202201ZYTS169"],"award-info":[{"award-number":["YDZJ202201ZYTS169"]}]},{"name":"The Jilin Province Science and Technology Development Plan","award":["YDZJ2022101ZYTS180"],"award-info":[{"award-number":["YDZJ2022101ZYTS180"]}]},{"name":"The Jilin Province Science and Technology Development Plan","award":["YDZJ202301ZYTS457"],"award-info":[{"award-number":["YDZJ202301ZYTS457"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["No.82304834"],"award-info":[{"award-number":["No.82304834"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Inflammopharmacol"],"published-print":{"date-parts":[[2025,9]]},"DOI":"10.1007\/s10787-025-01898-5","type":"journal-article","created":{"date-parts":[[2025,8,12]],"date-time":"2025-08-12T17:11:29Z","timestamp":1755018689000},"page":"5451-5469","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Cucurbitacin B alleviates DSS-induced experimental colitis by targeting ZNF70 to suppress the NLRP3\/STAT3 signaling axis"],"prefix":"10.1007","volume":"33","author":[{"given":"Shen","family":"Cao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuhan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Tai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanjin","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Can","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong Xiang","family":"Zuo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming Yue","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue","family":"Xing","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuejun","family":"Jin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6121-2486","authenticated-orcid":false,"given":"Juan","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,8,12]]},"reference":[{"issue":"4","key":"1898_CR1","doi-asserted-by":"publisher","first-page":"1461","DOI":"10.1080\/01480545.2020.1838538","volume":"45","author":"OS Aljohani","year":"2022","unstructured":"Aljohani OS (2022) Phytochemical evaluation of Cucumis prophetarum: protective effects against carrageenan-induced prostatitis in rats. Drug Chem Toxicol 45(4):1461\u20131469. https:\/\/doi.org\/10.1080\/01480545.2020.1838538","journal-title":"Drug Chem Toxicol"},{"key":"1898_CR2","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1016\/j.jare.2023.08.008","volume":"52","author":"Y An","year":"2023","unstructured":"An Y, Zhai Z, Wang X, Ding Y, He L, Li L, Mo Qi, Mu C, Xie R, Liu T, Zhong W, Wang B et al (2023) Targeting Desulfovibrio vulgaris flagellin-induced NAIP\/NLRC4 inflammasome activation in macrophages attenuates ulcerative colitis. J Adv Res 52:219\u2013232. https:\/\/doi.org\/10.1016\/j.jare.2023.08.008","journal-title":"J Adv Res"},{"key":"1898_CR3","doi-asserted-by":"publisher","DOI":"10.3390\/ph17070909","author":"HH Arab","year":"2024","unstructured":"Arab HH, Alsufyani SE, Ashour AM, Gad AM, Elhemiely AA, Gadelmawla MHA, Mahmoud MA et al (2024) Targeting JAK2\/STAT3, NLRP3\/Caspase-1, and PK2\/PKR2 pathways with arbutin ameliorates lead acetate-induced testicular injury in rats. Pharmaceuticals (Basel). https:\/\/doi.org\/10.3390\/ph17070909","journal-title":"Pharmaceuticals (Basel)"},{"key":"1898_CR4","doi-asserted-by":"publisher","DOI":"10.1016\/j.taap.2025.117239","volume":"496","author":"S Cao","year":"2025","unstructured":"Cao S, Lv B, Tai Y, Zuo HX, Xing Y, Surh YJ, Li MY, Ma J et al (2025) Formononetin ameliorates DSS-induced colitis by inhibiting the MAPK\/PPAR-\u03b3\/NF-\u03baB\/ROS signaling pathways. Toxicol Appl Pharmacol 496:117239. https:\/\/doi.org\/10.1016\/j.taap.2025.117239","journal-title":"Toxicol Appl Pharmacol"},{"key":"1898_CR5","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2023.104494","volume":"89","author":"J Chen","year":"2023","unstructured":"Chen J, Xu F, Ruan X, Sun J, Zhang Y, Zhang H, Zhao J, Zheng J, Larsson SC, Wang X, Li X et al (2023) Therapeutic targets for inflammatory bowel disease: proteome-wide Mendelian randomization and colocalization analyses. EBioMedicine 89:104494. https:\/\/doi.org\/10.1016\/j.ebiom.2023.104494","journal-title":"EBioMedicine"},{"key":"1898_CR6","doi-asserted-by":"publisher","DOI":"10.1093\/bbb\/zbac065","author":"X Chu","year":"2022","unstructured":"Chu X, Zhang L, Zhou Y, Fang Q (2022) Cucurbitacin B alleviates cerebral ischemia\/reperfusion injury by inhibiting NLRP3 inflammasome-mediated inflammation and reducing oxidative stress. Biosci Biotechnol Biochem. https:\/\/doi.org\/10.1093\/bbb\/zbac065","journal-title":"Biosci Biotechnol Biochem"},{"issue":"3","key":"1898_CR7","doi-asserted-by":"publisher","first-page":"968","DOI":"10.1124\/pharmrev.120.000171","volume":"73","author":"SE Corcoran","year":"2021","unstructured":"Corcoran SE, Halai R, Cooper MA (2021) Pharmacological inhibition of the Nod-like receptor family pyrin domain containing 3 inflammasome with MCC950. Pharmacol Rev 73(3):968\u20131000. https:\/\/doi.org\/10.1124\/pharmrev.120.000171","journal-title":"Pharmacol Rev"},{"key":"1898_CR8","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2022.106587","volume":"187","author":"S Dai","year":"2023","unstructured":"Dai S, Wang C, Zhao X, Ma C, Fu K, Liu Y, Peng C et al (2023) Cucurbitacin b: a review of its pharmacology, toxicity, and pharmacokinetics. Pharmacol Res 187:106587. https:\/\/doi.org\/10.1016\/j.phrs.2022.106587","journal-title":"Pharmacol Res"},{"issue":"3","key":"1898_CR9","doi-asserted-by":"publisher","first-page":"176","DOI":"10.1007\/s13238-013-2084-3","volume":"4","author":"Y Fan","year":"2013","unstructured":"Fan Y, Mao R, Yang J (2013) NF-\u03baB and STAT3 signaling pathways collaboratively link inflammation to cancer. Protein Cell 4(3):176\u2013185. https:\/\/doi.org\/10.1007\/s13238-013-2084-3","journal-title":"Protein Cell"},{"issue":"1","key":"1898_CR10","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-11662-3","volume":"10","author":"Y Fang","year":"2019","unstructured":"Fang Y, Shen ZY, Zhan YZ, Feng XC, Chen KL, Li YS (2019) CD36 inhibits \u03b2-catenin\/c-myc-mediated glycolysis through ubiquitination of GPC4 to repress colorectal tumorigenesis. Nat Commun 10(1):3981. https:\/\/doi.org\/10.1038\/s41467-019-11662-3","journal-title":"Nat Commun"},{"key":"1898_CR11","doi-asserted-by":"publisher","first-page":"301","DOI":"10.1146\/annurev-immunol-081022-021207","volume":"41","author":"J Fu","year":"2023","unstructured":"Fu J, Wu H (2023) Structural mechanisms of NLRP3 inflammasome assembly and activation. Annu Rev Immunol 41:301\u2013316. https:\/\/doi.org\/10.1146\/annurev-immunol-081022-021207","journal-title":"Annu Rev Immunol"},{"issue":"10","key":"1898_CR12","doi-asserted-by":"publisher","first-page":"680","DOI":"10.1093\/ijnp\/pyad052","volume":"26","author":"JB Ge","year":"2023","unstructured":"Ge JB, Jiang B, Shi TS, Li WY, Chen WJ, Zhu BL, Qin ZH (2023) Cucurbitacin B exerts significant antidepressant-like effects in a chronic unpredictable mild stress model of depression: involvement of the hippocampal BDNF-TrkB system. Int J Neuropsychopharmacol 26(10):680\u2013691. https:\/\/doi.org\/10.1093\/ijnp\/pyad052","journal-title":"Int J Neuropsychopharmacol"},{"issue":"10","key":"1898_CR13","doi-asserted-by":"publisher","first-page":"951","DOI":"10.1001\/jama.2023.15389","volume":"330","author":"B Gros","year":"2023","unstructured":"Gros B, Kaplan GG (2023) Ulcerative colitis in adults: a review. JAMA 330(10):951\u2013965. https:\/\/doi.org\/10.1001\/jama.2023.15389","journal-title":"JAMA"},{"issue":"3","key":"1898_CR14","doi-asserted-by":"publisher","first-page":"282","DOI":"10.1097\/cad.0000000000000833","volume":"31","author":"GL Han","year":"2020","unstructured":"Han GL, Wang J, Guo K, Chen JK, Shang RX, Jiang T (2020) MiRNA-574-5p downregulates ZNF70 and influences the progression of human esophageal squamous cell carcinoma through reactive oxygen species generation and MAPK pathway activation. Anticancer Drugs 31(3):282\u2013291. https:\/\/doi.org\/10.1097\/cad.0000000000000833","journal-title":"Anticancer Drugs"},{"key":"1898_CR15","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2024.117956","volume":"328","author":"Y Hu","year":"2024","unstructured":"Hu Y, Tang J, Xie Y, Xu W, Zhu W, Xia L, Fang J, Yu D, Liu J, Zheng Z, Zhou Q, Shou Q et al (2024) Gegen qinlian decoction ameliorates TNBS-induced ulcerative colitis by regulating Th2\/Th1 and Tregs\/Th17 cells balance, inhibiting NLRP3 inflammasome activation and reshaping gut microbiota. J Ethnopharmacol 328:117956. https:\/\/doi.org\/10.1016\/j.jep.2024.117956","journal-title":"J Ethnopharmacol"},{"key":"1898_CR16","doi-asserted-by":"publisher","first-page":"375","DOI":"10.1016\/j.freeradbiomed.2022.06.242","volume":"188","author":"F Huang","year":"2022","unstructured":"Huang F, Zhang S, Li X, Huang Y, He S, Luo L (2022) STAT3-mediated ferroptosis is involved in ulcerative colitis. Free Radic Biol Med 188:375\u2013385. https:\/\/doi.org\/10.1016\/j.freeradbiomed.2022.06.242","journal-title":"Free Radic Biol Med"},{"issue":"1","key":"1898_CR17","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1186\/s12906-019-2568-7","volume":"19","author":"N Hunsakunachai","year":"2019","unstructured":"Hunsakunachai N, Nuengchamnong N, Jiratchariyakul W, Kummalue T, Khemawoot P (2019) Pharmacokinetics of cucurbitacin B from Trichosanthes cucumerina L. in rats. BMC Complement Altern Med 19(1):157. https:\/\/doi.org\/10.1186\/s12906-019-2568-7","journal-title":"BMC Complement Altern Med"},{"key":"1898_CR18","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1007\/978-1-62703-523-1_9","volume":"1040","author":"C Jakobs","year":"2013","unstructured":"Jakobs C, Bartok E, Kubarenko A, Bauernfeind F, Hornung V (2013) Immunoblotting for active caspase-1. Methods Mol Biol 1040:103\u2013115. https:\/\/doi.org\/10.1007\/978-1-62703-523-1_9","journal-title":"Methods Mol Biol"},{"issue":"1","key":"1898_CR19","doi-asserted-by":"publisher","first-page":"78","DOI":"10.1007\/s12640-021-00456-5","volume":"40","author":"N Ji","year":"2022","unstructured":"Ji N, Wu L, Shi H, Li Q, Yu A, Yang Z (2022) VSIG4 attenuates NLRP3 and ameliorates neuroinflammation via JAK2-STAT3-A20 pathway after intracerebral hemorrhage in mice. Neurotox Res 40(1):78\u201388. https:\/\/doi.org\/10.1007\/s12640-021-00456-5","journal-title":"Neurotox Res"},{"issue":"21","key":"1898_CR20","doi-asserted-by":"publisher","first-page":"7146","DOI":"10.1021\/jo101242e","volume":"75","author":"ME Jung","year":"2010","unstructured":"Jung ME, Lui RM (2010) Studies toward the total syntheses of cucurbitacins B and D. J Org Chem 75(21):7146\u20137158. https:\/\/doi.org\/10.1021\/jo101242e","journal-title":"J Org Chem"},{"issue":"1","key":"1898_CR21","doi-asserted-by":"publisher","DOI":"10.1038\/s41572-020-0205-x","volume":"6","author":"T Kobayashi","year":"2020","unstructured":"Kobayashi T, Siegmund B, Le Berre C, Wei SC, Ferrante M, Shen B, Bernstein CN, Danese S, Peyrin-Biroulet L et al (2020) Ulcerative colitis. Nat Rev Dis Primers 6(1):74. https:\/\/doi.org\/10.1038\/s41572-020-0205-x","journal-title":"Nat Rev Dis Primers"},{"issue":"33\u201334","key":"1898_CR22","doi-asserted-by":"publisher","first-page":"564","DOI":"10.3238\/arztebl.2020.0564","volume":"117","author":"T Kucharzik","year":"2020","unstructured":"Kucharzik T, Koletzko S, Kannengiesser K, Dignass A (2020) Ulcerative colitis-diagnostic and therapeutic algorithms. Dtsch Arztebl Int 117(33\u201334):564\u2013574. https:\/\/doi.org\/10.3238\/arztebl.2020.0564","journal-title":"Dtsch Arztebl Int"},{"key":"1898_CR23","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23137130","author":"E Kusagawa","year":"2022","unstructured":"Kusagawa E, Okuda C, Yamaguchi R, Nakano K, Miyake Y, Kataoka T (2022) Cucurbitacin b down-regulates TNF receptor 1 expression and inhibits the TNF-\u03b1-dependent nuclear factor \u03baB signaling pathway in human lung adenocarcinoma A549 cells. Int J Mol Sci. https:\/\/doi.org\/10.3390\/ijms23137130","journal-title":"Int J Mol Sci"},{"issue":"1","key":"1898_CR24","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1016\/s0959-440x(00)00167-6","volume":"11","author":"JH Laity","year":"2001","unstructured":"Laity JH, Lee BM, Wright PE (2001) Zinc finger proteins: new insights into structural and functional diversity. Curr Opin Struct Biol 11(1):39\u201346. https:\/\/doi.org\/10.1016\/s0959-440x(00)00167-6","journal-title":"Curr Opin Struct Biol"},{"issue":"10401","key":"1898_CR25","doi-asserted-by":"publisher","first-page":"571","DOI":"10.1016\/s0140-6736(23)00966-2","volume":"402","author":"C Le Berre","year":"2023","unstructured":"Le Berre C, Honap S, Peyrin-Biroulet L (2023) Ulcerative colitis. Lancet 402(10401):571\u2013584. https:\/\/doi.org\/10.1016\/s0140-6736(23)00966-2","journal-title":"Lancet"},{"issue":"4","key":"1898_CR26","doi-asserted-by":"publisher","first-page":"673","DOI":"10.1016\/j.bbrc.2015.03.001","volume":"459","author":"ZJ Li","year":"2015","unstructured":"Li ZJ, Shin JM, Choi DK, Lim SK, Yoon TJ, Lee YH, Sohn K-C, Im M, Lee Y, Seo Y-J, Kim CD et al (2015) Inhibitory effect of cucurbitacin B on imiquimod-induced skin inflammation. Biochem Biophys Res Commun 459(4):673\u2013678. https:\/\/doi.org\/10.1016\/j.bbrc.2015.03.001","journal-title":"Biochem Biophys Res Commun"},{"issue":"6","key":"1898_CR27","doi-asserted-by":"publisher","first-page":"6345","DOI":"10.3892\/ol.2017.7091","volume":"14","author":"W Li","year":"2017","unstructured":"Li W, Zhang H, Min P, Zhu J, Xu D, Jiang W et al (2017) Downregulated miRNA-1269a variant (rs73239138) decreases the susceptibility to gastric cancer via targeting ZNF70. Oncol Lett 14(6):6345\u20136354. https:\/\/doi.org\/10.3892\/ol.2017.7091","journal-title":"Oncol Lett"},{"key":"1898_CR28","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2023.155052","volume":"120","author":"C Li","year":"2023","unstructured":"Li C, Gong L, Jiang Y, Huo X, Huang L, Lei H, Gu Y, Wang D, Guo D et al (2023) Sanguisorba officinalis ethyl acetate extract attenuates ulcerative colitis through inhibiting PI3K-AKT\/NF-\u03baB\/ STAT3 pathway uncovered by single-cell RNA sequencing. Phytomedicine 120:155052. https:\/\/doi.org\/10.1016\/j.phymed.2023.155052","journal-title":"Phytomedicine"},{"key":"1898_CR29","doi-asserted-by":"publisher","DOI":"10.1038\/srep28956","volume":"6","author":"S Liu","year":"2016","unstructured":"Liu S, Li Q, Zhang MT, Mao-Ying QL, Hu LY, Wu GC, Mi W-L et al (2016) Curcumin ameliorates neuropathic pain by down-regulating spinal IL-1\u03b2 via suppressing astroglial NALP1 inflammasome and JAK2-STAT3 signalling. Sci Rep 6:28956. https:\/\/doi.org\/10.1038\/srep28956","journal-title":"Sci Rep"},{"issue":"1","key":"1898_CR30","doi-asserted-by":"publisher","first-page":"154","DOI":"10.1080\/13880209.2021.2016866","volume":"60","author":"JH Liu","year":"2022","unstructured":"Liu JH, Li C, Cao L, Zhang CH, Zhang ZH (2022a) Cucurbitacin B regulates lung cancer cell proliferation and apoptosis via inhibiting the IL-6\/STAT3 pathway through the lncRNA XIST\/miR-let-7c axis. Pharm Biol 60(1):154\u2013162. https:\/\/doi.org\/10.1080\/13880209.2021.2016866","journal-title":"Pharm Biol"},{"issue":"2","key":"1898_CR31","doi-asserted-by":"publisher","first-page":"71","DOI":"10.31083\/j.fbl2702071","volume":"27","author":"Z Liu","year":"2022","unstructured":"Liu Z, Kumar M, Kabra A (2022b) Cucurbitacin B exerts neuroprotection in a murine Alzheimer\u2019s disease model by modulating oxidative stress, inflammation, and neurotransmitter levels. Front Biosci (Landmark Ed) 27(2):71. https:\/\/doi.org\/10.31083\/j.fbl2702071","journal-title":"Front Biosci (Landmark Ed)"},{"issue":"1","key":"1898_CR32","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1016\/j.gastrohep.2020.04.012","volume":"44","author":"A L\u00f3pez-Sanrom\u00e1n","year":"2021","unstructured":"L\u00f3pez-Sanrom\u00e1n A, Esplugues JV, Dom\u00e8nech E (2021) Pharmacology and safety of tofacitinib in ulcerative colitis. Gastroenterol Hepatol 44(1):39\u201348. https:\/\/doi.org\/10.1016\/j.gastrohep.2020.04.012","journal-title":"Gastroenterol Hepatol"},{"issue":"7","key":"1898_CR33","doi-asserted-by":"publisher","first-page":"3352","DOI":"10.1002\/ptr.8209","volume":"38","author":"C Lou","year":"2024","unstructured":"Lou C, Fang Y, Mei Y, Hu W, Sun L, Jin C, Chen H et al (2024) Cucurbitacin B attenuates osteoarthritis development by inhibiting NLRP3 inflammasome activation and pyroptosis through activating Nrf2\/HO-1 pathway. Phytother Res 38(7):3352\u20133369. https:\/\/doi.org\/10.1002\/ptr.8209","journal-title":"Phytother Res"},{"issue":"3","key":"1898_CR34","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2021.103017","volume":"21","author":"H Nakase","year":"2022","unstructured":"Nakase H, Sato N, Mizuno N, Ikawa Y (2022) The influence of cytokines on the complex pathology of ulcerative colitis. Autoimmun Rev 21(3):103017. https:\/\/doi.org\/10.1016\/j.autrev.2021.103017","journal-title":"Autoimmun Rev"},{"issue":"6571","key":"1898_CR35","doi-asserted-by":"publisher","first-page":"1076","DOI":"10.1126\/science.abi5934","volume":"374","author":"K Newton","year":"2021","unstructured":"Newton K, Dixit VM, Kayagaki N (2021) Dying cells fan the flames of inflammation. Science 374(6571):1076\u20131080. https:\/\/doi.org\/10.1126\/science.abi5934","journal-title":"Science"},{"key":"1898_CR36","doi-asserted-by":"publisher","DOI":"10.3390\/molecules29174193","author":"W Nie","year":"2024","unstructured":"Nie W, Wang Y, Tian X, Liu J, Jin Z, Xu J, He M, Shen Q, Guo H et al (2024) Cucurbitacin B and its derivatives: a review of progress in biological activities. Molecules. https:\/\/doi.org\/10.3390\/molecules29174193","journal-title":"Molecules"},{"issue":"8","key":"1898_CR37","doi-asserted-by":"publisher","first-page":"2937","DOI":"10.1007\/s11011-022-01083-5","volume":"37","author":"S Reiszadeh-Jahromi","year":"2022","unstructured":"Reiszadeh-Jahromi S, Haddadi M, Mousavi P, Sanadgol N (2022) Prophylactic effects of cucurbitacin B in the EAE model of multiple sclerosis by adjustment of STAT3\/IL-23\/IL-17 axis and improvement of neuropsychological symptoms. Metab Brain Dis 37(8):2937\u20132953. https:\/\/doi.org\/10.1007\/s11011-022-01083-5","journal-title":"Metab Brain Dis"},{"key":"1898_CR38","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1016\/j.fct.2013.11.040","volume":"64","author":"CR Seo","year":"2014","unstructured":"Seo CR, Yang DK, Song NJ, Yun UJ, Gwon AR, Jo DG, Cho JY, Yoon K, Ahn J-Y, Nho CW, Park WJ, Yang SY et al (2014) Cucurbitacin B and cucurbitacin I suppress adipocyte differentiation through inhibition of STAT3 signaling. Food Chem Toxicol 64:217\u2013224. https:\/\/doi.org\/10.1016\/j.fct.2013.11.040","journal-title":"Food Chem Toxicol"},{"issue":"8","key":"1898_CR39","doi-asserted-by":"publisher","first-page":"477","DOI":"10.1038\/s41577-019-0165-0","volume":"19","author":"KV Swanson","year":"2019","unstructured":"Swanson KV, Deng M, Ting JP (2019) The NLRP3 inflammasome: molecular activation and regulation to therapeutics. Nat Rev Immunol 19(8):477\u2013489. https:\/\/doi.org\/10.1038\/s41577-019-0165-0","journal-title":"Nat Rev Immunol"},{"issue":"1","key":"1898_CR40","doi-asserted-by":"publisher","first-page":"862","DOI":"10.1080\/10717544.2018.1425773","volume":"25","author":"L Tang","year":"2018","unstructured":"Tang L, Fu L, Zhu Z, Yang Y, Sun B, Shan W, Zhang Z (2018) Modified mixed nanomicelles with collagen peptides enhanced oral absorption of Cucurbitacin B: preparation and evaluation. Drug Deliv 25(1):862\u2013871. https:\/\/doi.org\/10.1080\/10717544.2018.1425773","journal-title":"Drug Deliv"},{"issue":"10080","key":"1898_CR41","doi-asserted-by":"publisher","first-page":"1756","DOI":"10.1016\/s0140-6736(16)32126-2","volume":"389","author":"R Ungaro","year":"2017","unstructured":"Ungaro R, Mehandru S, Allen PB, Peyrin-Biroulet L, Colombel JF (2017) Ulcerative colitis. Lancet 389(10080):1756\u20131770. https:\/\/doi.org\/10.1016\/s0140-6736(16)32126-2","journal-title":"Lancet"},{"key":"1898_CR42","doi-asserted-by":"publisher","DOI":"10.3390\/ijms25010348","author":"JM Wang","year":"2023","unstructured":"Wang JM, Yang J, Xia WY, Wang YM, Zhu YB, Huang Q, Feng T, Xie L-S, Li S-H, Liu S-Q, Yu S-G et al (2023) Comprehensive analysis of PANoptosis-related gene signature of ulcerative colitis. Int J Mol Sci. https:\/\/doi.org\/10.3390\/ijms25010348","journal-title":"Int J Mol Sci"},{"key":"1898_CR43","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2021.153743","volume":"92","author":"YY Wei","year":"2021","unstructured":"Wei YY, Fan YM, Ga Y, Zhang YN, Han JC, Hao ZH (2021) Shaoyao decoction attenuates DSS-induced ulcerative colitis, macrophage and NLRP3 inflammasome activation through the MKP1\/NF-\u03baB pathway. Phytomedicine 92:153743. https:\/\/doi.org\/10.1016\/j.phymed.2021.153743","journal-title":"Phytomedicine"},{"issue":"13","key":"1898_CR44","doi-asserted-by":"publisher","first-page":"5056","DOI":"10.7150\/ijbs.74304","volume":"18","author":"X Wu","year":"2022","unstructured":"Wu X, Wei S, Chen M, Li J, Wei Y, Zhang J, Dong W (2022) P2RY13 exacerbates intestinal inflammation by damaging the intestinal mucosal barrier via activating IL-6\/STAT3 pathway. Int J Biol Sci 18(13):5056\u20135069. https:\/\/doi.org\/10.7150\/ijbs.74304","journal-title":"Int J Biol Sci"},{"issue":"11","key":"1898_CR45","doi-asserted-by":"publisher","first-page":"3899","DOI":"10.1002\/jcb.26041","volume":"118","author":"Y Xiao","year":"2017","unstructured":"Xiao Y, Yang Z, Wu QQ, Jiang XH, Yuan Y, Chang W, Wu Q-Q, Jiang X-H, Bian ZY, Zhu JX, Tang Q-Z et al (2017) Cucurbitacin B protects against pressure overload induced cardiac hypertrophy. J Cell Biochem 118(11):3899\u20133910. https:\/\/doi.org\/10.1002\/jcb.26041","journal-title":"J Cell Biochem"},{"issue":"4","key":"1898_CR46","doi-asserted-by":"publisher","first-page":"331","DOI":"10.1016\/j.tibs.2022.10.002","volume":"48","author":"J Xu","year":"2023","unstructured":"Xu J, N\u00fa\u00f1ez G (2023) The NLRP3 inflammasome: activation and regulation. Trends Biochem Sci 48(4):331\u2013344. https:\/\/doi.org\/10.1016\/j.tibs.2022.10.002","journal-title":"Trends Biochem Sci"},{"key":"1898_CR47","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.963291","volume":"13","author":"Q Xu","year":"2022","unstructured":"Xu Q, Sun W, Zhang J, Mei Y, Bao J, Hou S, Zhou X et al (2022) Inflammasome-targeting natural compounds in inflammatory bowel disease: mechanisms and therapeutic potential. Front Immunol 13:963291. https:\/\/doi.org\/10.3389\/fimmu.2022.963291","journal-title":"Front Immunol"},{"issue":"2","key":"1898_CR48","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1530\/jme-20-0305","volume":"67","author":"Y Xue","year":"2021","unstructured":"Xue Y, Li R, Fang P, Ye ZQ, Zhao Y, Zhou Y, Zhang K-Q et al (2021) NLRP3 inflammasome inhibitor cucurbitacin B suppresses gout arthritis in mice. J Mol Endocrinol 67(2):27\u201340. https:\/\/doi.org\/10.1530\/jme-20-0305","journal-title":"J Mol Endocrinol"},{"issue":"5","key":"1898_CR49","doi-asserted-by":"publisher","first-page":"526","DOI":"10.1177\/0960327115595686","volume":"35","author":"AS Yar Saglam","year":"2016","unstructured":"Yar Saglam AS, Alp E, Elmazoglu Z, Menevse S (2016) Treatment with cucurbitacin B alone and in combination with gefitinib induces cell cycle inhibition and apoptosis via EGFR and JAK\/STAT pathway in human colorectal cancer cell lines. Hum Exp Toxicol 35(5):526\u2013543. https:\/\/doi.org\/10.1177\/0960327115595686","journal-title":"Hum Exp Toxicol"},{"key":"1898_CR50","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2024.176805","volume":"978","author":"Z Zeng","year":"2024","unstructured":"Zeng Z, Hu Y, Xiang J, Su J, Tan H, Lai T, Chen X, Fang G, Li Li et al (2024) Cucurbitacin B targets STAT3 to induce ferroptosis in non-small cell lung cancer. Eur J Pharmacol 978:176805. https:\/\/doi.org\/10.1016\/j.ejphar.2024.176805","journal-title":"Eur J Pharmacol"},{"key":"1898_CR51","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2020.153172","volume":"68","author":"ZH Zhang","year":"2020","unstructured":"Zhang ZH, Li MY, Wang Z, Zuo HX, Wang JY, Xing Y, Jin C, Xu G, Piao L, Piao H, Ma J et al (2020) Convallatoxin promotes apoptosis and inhibits proliferation and angiogenesis through crosstalk between JAK2\/STAT3 (T705) and mTOR\/STAT3 (S727) signaling pathways in colorectal cancer. Phytomedicine 68:153172. https:\/\/doi.org\/10.1016\/j.phymed.2020.153172","journal-title":"Phytomedicine"},{"key":"1898_CR52","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2021.114915","volume":"287","author":"H Zhang","year":"2022","unstructured":"Zhang H, Zhao B, Wei H, Zeng H, Sheng D, Zhang Y (2022) Cucurbitacin B controls M2 macrophage polarization to suppresses metastasis via targeting JAK-2\/STAT3 signalling pathway in colorectal cancer. J Ethnopharmacol 287:114915. https:\/\/doi.org\/10.1016\/j.jep.2021.114915","journal-title":"J Ethnopharmacol"},{"issue":"14","key":"1898_CR53","doi-asserted-by":"publisher","first-page":"1106","DOI":"10.2174\/0113894501255960231101105113","volume":"24","author":"J Zhang","year":"2023","unstructured":"Zhang J, Zeng S, Wang P, Chen Y, Zeng C (2023) NLRP3: a promising therapeutic target for inflammatory bowel disease. Curr Drug Targets 24(14):1106\u20131116. https:\/\/doi.org\/10.2174\/0113894501255960231101105113","journal-title":"Curr Drug Targets"},{"key":"1898_CR54","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellsig.2023.110979","volume":"114","author":"Z Zhang","year":"2024","unstructured":"Zhang Z, Li M, Tai Y, Xing Y, Zuo H, Jin X, Ma J (2024) ZNF70 regulates IL-1\u03b2 secretion of macrophages to promote the proliferation of HCT116 cells via activation of NLRP3 inflammasome and STAT3 pathway in colitis-associated colorectal cancer. Cell Signal 114:110979. https:\/\/doi.org\/10.1016\/j.cellsig.2023.110979","journal-title":"Cell Signal"},{"key":"1898_CR55","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2021.153519","volume":"84","author":"Y Zhao","year":"2021","unstructured":"Zhao Y, Luan H, Jiang H, Xu Y, Wu X, Zhang Y, Li R (2021) Gegen qinlian decoction relieved DSS-induced ulcerative colitis in mice by modulating Th17\/Treg cell homeostasis via suppressing IL-6\/JAK2\/STAT3 signaling. Phytomedicine 84:153519. https:\/\/doi.org\/10.1016\/j.phymed.2021.153519","journal-title":"Phytomedicine"},{"key":"1898_CR56","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.00276","volume":"10","author":"Y Zhen","year":"2019","unstructured":"Zhen Y, Zhang H (2019) NLRP3 inflammasome and inflammatory bowel disease. Front Immunol 10:276. https:\/\/doi.org\/10.3389\/fimmu.2019.00276","journal-title":"Front Immunol"},{"key":"1898_CR57","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.714943","volume":"12","author":"H Zhu","year":"2021","unstructured":"Zhu H, Jian Z, Zhong Y, Ye Y, Zhang Y, Hu X, Pu B, Gu L et al (2021) Janus kinase inhibition ameliorates ischemic stroke injury and neuroinflammation through reducing NLRP3 inflammasome activation via JAK2\/STAT3 pathway inhibition. Front Immunol 12:714943. https:\/\/doi.org\/10.3389\/fimmu.2021.714943","journal-title":"Front Immunol"}],"container-title":["Inflammopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10787-025-01898-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10787-025-01898-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10787-025-01898-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,17]],"date-time":"2025-09-17T04:15:32Z","timestamp":1758082532000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10787-025-01898-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8,12]]},"references-count":57,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2025,9]]}},"alternative-id":["1898"],"URL":"https:\/\/doi.org\/10.1007\/s10787-025-01898-5","relation":{},"ISSN":["0925-4692","1568-5608"],"issn-type":[{"value":"0925-4692","type":"print"},{"value":"1568-5608","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,8,12]]},"assertion":[{"value":"17 June 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 July 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 August 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"All animal studies were approved by the Guidelines for Animal Ethics of Yanbian University (YD20241126011) and were conducted in accordance with the ethical standards established in the Declaration of Helsinki.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval and consent to participate"}}]}}