{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T19:09:57Z","timestamp":1782155397702,"version":"3.54.5"},"reference-count":68,"publisher":"Springer Science and Business Media LLC","issue":"9","license":[{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100005307","name":"DGRSDT","doi-asserted-by":"crossref","award":["PRFU project (D01N01UN1501202300002\/2023)."],"award-info":[{"award-number":["PRFU project (D01N01UN1501202300002\/2023)."]}],"id":[{"id":"10.13039\/501100005307","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Inflammopharmacol"],"published-print":{"date-parts":[[2025,9]]},"DOI":"10.1007\/s10787-025-01905-9","type":"journal-article","created":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T06:47:45Z","timestamp":1756709265000},"page":"5387-5407","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Orange peel extract and hesperidin attenuate myeloperoxidase activity and oxidative stress in vitro, with anti-inflammatory effects in vivo: a natural approach to gingival protection"],"prefix":"10.1007","volume":"33","author":[{"given":"Tinhinane","family":"Rekeb","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5486-714X","authenticated-orcid":false,"given":"Samia","family":"Bedouhene","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nassima","family":"Senani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sahra-Amel","family":"Belambri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meriem-Dehbia","family":"Chabane","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kahina","family":"Ladj","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Riadh","family":"Ksouri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pham My-Chan","family":"Dang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jamel El","family":"Benna","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,9,1]]},"reference":[{"key":"1905_CR1","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2021.811080","volume":"15","author":"M Aalikhani","year":"2022","unstructured":"Aalikhani M, Safdari Y, Jahanshahi M et al (2022) Comparison between hesperidin, coumarin, and deferoxamine iron chelation and antioxidant activity against excessive iron in the iron overloaded mice. Front Neurosci 15:811080. https:\/\/doi.org\/10.3389\/fnins.2021.811080","journal-title":"Front Neurosci"},{"key":"1905_CR2","doi-asserted-by":"publisher","first-page":"563","DOI":"10.1080\/13510002.2017.1344013","volume":"22","author":"SA Adefegha","year":"2017","unstructured":"Adefegha SA, Rosa Leal DB, Olabiyi AA et al (2017) Hesperidin attenuates inflammation and oxidative damage in pleural exudates and liver of rat model of pleurisy. Redox Rep 22:563\u2013571. https:\/\/doi.org\/10.1080\/13510002.2017.1344013","journal-title":"Redox Rep"},{"key":"1905_CR3","doi-asserted-by":"publisher","first-page":"342","DOI":"10.1016\/j.fct.2010.11.003","volume":"49","author":"A Akrout","year":"2011","unstructured":"Akrout A, Gonzalez LA, El Jani H, Madrid PC (2011) Antioxidant and antitumor activities of Artemisia campestris and Thymelaea hirsuta from southern Tunisia. Food Chem Toxicol 49:342\u2013347. https:\/\/doi.org\/10.1016\/j.fct.2010.11.003","journal-title":"Food Chem Toxicol"},{"key":"1905_CR4","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1111\/bph.13645","volume":"174","author":"X Bai","year":"2017","unstructured":"Bai X, Yang P, Zhou Q et al (2017) The protective effect of the natural compound hesperetin against fulminant hepatitis in vivo and in vitro. Br J Pharmacol 174:41\u201356. https:\/\/doi.org\/10.1111\/bph.13645","journal-title":"Br J Pharmacol"},{"key":"1905_CR5","doi-asserted-by":"publisher","first-page":"673","DOI":"10.1007\/s10787-017-0367-7","volume":"25","author":"S Bedouhene","year":"2017","unstructured":"Bedouhene S, Moulti-Mati F, Dang PM-C, El-Benna J (2017) Oleuropein and hydroxytyrosol inhibit the N-formyl-methionyl-leucyl-phenylalanine-induced neutrophil degranulation and chemotaxis via AKT, p38, and ERK1\/2 MAP-kinase inhibition. Inflammopharmacol 25:673\u2013680. https:\/\/doi.org\/10.1007\/s10787-017-0367-7","journal-title":"Inflammopharmacol"},{"key":"1905_CR6","doi-asserted-by":"publisher","first-page":"1130","DOI":"10.3390\/biomedicines9091130","volume":"9","author":"S Bedouhene","year":"2021","unstructured":"Bedouhene S, Liu M, Senani N et al (2021) Prolyl-isomerase Pin1 controls key fMLP-induced neutrophil functions. Biomedicines 9:1130. https:\/\/doi.org\/10.3390\/biomedicines9091130","journal-title":"Biomedicines"},{"key":"1905_CR7","doi-asserted-by":"publisher","first-page":"29","DOI":"10.14715\/cmb\/2024.70.7.5","volume":"70","author":"S Bedouhene","year":"2024","unstructured":"Bedouhene S, Senani N, Rekeb T et al (2024) Dual protection of aqueous garlic extract biomolecules against hemolysis and itsoxidation products in preventing inflammation. Cell Mol Biol (Noisy-Le-Grand) 70:29\u201337. https:\/\/doi.org\/10.14715\/cmb\/2024.70.7.5","journal-title":"Cell Mol Biol (Noisy-Le-Grand)"},{"key":"1905_CR8","unstructured":"Boizot N, Charpentier J-P (2006) M\u00e9thode rapide d\u2019\u00e9valuation du contenu en compos\u00e9s ph\u00e9noliques des organes d\u2019un arbre forestier"},{"key":"1905_CR9","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2024.112425","volume":"137","author":"T Boussetta","year":"2024","unstructured":"Boussetta T, Raad H, Bedouhene S et al (2024) The peptidyl-prolyl isomerase Pin1 controls GM-CSF-induced priming of NADPH oxidase in human neutrophils and priming at inflammatory sites. Int Immunopharmacol 137:112425. https:\/\/doi.org\/10.1016\/j.intimp.2024.112425","journal-title":"Int Immunopharmacol"},{"key":"1905_CR10","doi-asserted-by":"publisher","DOI":"10.1007\/s10787-025-01797-9","author":"M-D Chabane","year":"2025","unstructured":"Chabane M-D, Bedouhene S, Belambri S-A et al (2025) Bee venom modulates human neutrophil inflammatory functions in vitro and exerts an anti- inflammatory effect in vivo in rats. Inflammopharmacol. https:\/\/doi.org\/10.1007\/s10787-025-01797-9","journal-title":"Inflammopharmacol"},{"key":"1905_CR11","doi-asserted-by":"publisher","first-page":"2119","DOI":"10.1016\/j.foodchem.2012.07.041","volume":"135","author":"Z-T Chen","year":"2012","unstructured":"Chen Z-T, Chu H-L, Chyau C-C et al (2012) Protective effects of sweet orange (Citrus sinensis) peel and their bioactive compounds on oxidative stress. Food Chem 135:2119\u20132127. https:\/\/doi.org\/10.1016\/j.foodchem.2012.07.041","journal-title":"Food Chem"},{"key":"1905_CR12","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2012\/181295","volume":"2012","author":"M Ciz","year":"2012","unstructured":"Ciz M, Denev P, Kratchanova M et al (2012) Flavonoids inhibit the respiratory burst of neutrophils in mammals. Oxid Med Cell Longev 2012:1\u20136. https:\/\/doi.org\/10.1155\/2012\/181295","journal-title":"Oxid Med Cell Longev"},{"key":"1905_CR13","doi-asserted-by":"publisher","DOI":"10.1016\/j.prmcm.2023.100272","volume":"8","author":"P Dongre","year":"2023","unstructured":"Dongre P, Doifode C, Choudhary S, Sharma N (2023) Botanical description, chemical composition, traditional uses and pharmacology of Citrus sinensis: an updated review. Pharmacol Res-Mod Chin Med 8:100272. https:\/\/doi.org\/10.1016\/j.prmcm.2023.100272","journal-title":"Pharmacol Res-Mod Chin Med"},{"key":"1905_CR14","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2022.112914","volume":"149","author":"AC Famurewa","year":"2022","unstructured":"Famurewa AC, Renu K, Eladl MA et al (2022) Hesperidin and hesperetin against heavy metal toxicity: insight on the molecular mechanism of mitigation. Biomed Pharmacother 149:112914. https:\/\/doi.org\/10.1016\/j.biopha.2022.112914","journal-title":"Biomed Pharmacother"},{"key":"1905_CR15","doi-asserted-by":"publisher","first-page":"1529","DOI":"10.1007\/s10787-023-01208-x","volume":"31","author":"N Fayez","year":"2023","unstructured":"Fayez N, Khalil W, Abdel-Sattar E, Abdel-Fattah A-FM (2023) In vitro and in vivo assessment of the anti-inflammatory activity of olive leaf extract in rats. Inflammopharmacol 31:1529\u20131538. https:\/\/doi.org\/10.1007\/s10787-023-01208-x","journal-title":"Inflammopharmacol"},{"key":"1905_CR17","doi-asserted-by":"publisher","first-page":"23","DOI":"10.3390\/antiox12010023","volume":"12","author":"G Fontana","year":"2022","unstructured":"Fontana G, Bruno M, Sottile F, Badalamenti N (2022) The chemistry and the anti-inflammatory activity of polymethoxyflavonoids from Citrus genus. Antioxidants 12:23. https:\/\/doi.org\/10.3390\/antiox12010023","journal-title":"Antioxidants"},{"key":"1905_CR18","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1016\/j.freeradbiomed.2024.12.046","volume":"228","author":"A Gardette","year":"2025","unstructured":"Gardette A, Marzaioli V, Bedouhene S et al (2025) The protein tyrosine phosphatase Lyp\/PTPN22 drives TNF\u03b1-induced priming of superoxide anions production by neutrophils and arthritis. Free Radic Biol Med 228:68\u201378. https:\/\/doi.org\/10.1016\/j.freeradbiomed.2024.12.046","journal-title":"Free Radic Biol Med"},{"key":"1905_CR19","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbi.2020.109315","volume":"333","author":"CFS Guazelli","year":"2021","unstructured":"Guazelli CFS, Fattori V, Ferraz CR et al (2021) Antioxidant and anti-inflammatory effects of hesperidin methyl chalcone in experimental ulcerative colitis. Chem Biol Interact 333:109315. https:\/\/doi.org\/10.1016\/j.cbi.2020.109315","journal-title":"Chem Biol Interact"},{"key":"1905_CR21","doi-asserted-by":"publisher","first-page":"869","DOI":"10.3389\/fphys.2017.00869","volume":"8","author":"P Hern\u00e1ndez-R\u00edos","year":"2017","unstructured":"Hern\u00e1ndez-R\u00edos P, Pussinen PJ, Vernal R, Hern\u00e1ndez M (2017) Oxidative stress in the local and systemic events of apical periodontitis. Front Physiol 8:869. https:\/\/doi.org\/10.3389\/fphys.2017.00869","journal-title":"Front Physiol"},{"key":"1905_CR22","doi-asserted-by":"publisher","first-page":"937","DOI":"10.3390\/life13040937","volume":"13","author":"S Hosawi","year":"2023","unstructured":"Hosawi S (2023) Current update on role of Hesperidin in inflammatory lung diseases: chemistry, pharmacology, and drug delivery approaches. Life (Basel) 13:937. https:\/\/doi.org\/10.3390\/life13040937","journal-title":"Life (Basel)"},{"key":"1905_CR23","doi-asserted-by":"publisher","DOI":"10.31579\/2637-8876\/007","author":"GC Jagetia","year":"2018","unstructured":"Jagetia GC (2018) A review on the anti-inflammatory activity of hesperidin, a bioflavonoid synthesized by citrus fruits. Immunol Inflam Dis Ther. https:\/\/doi.org\/10.31579\/2637-8876\/007","journal-title":"Immunol Inflam Dis Ther"},{"key":"1905_CR24","doi-asserted-by":"publisher","DOI":"10.26717\/BJSTR.2018.08.001602","author":"GC Jagetia","year":"2018","unstructured":"Jagetia GC, Lalrinpuii T (2018) Hesperidin, a citrus bioflavonoid attnuates iron- induced biochemical oxidative stress in mouse liver. BJSTR. https:\/\/doi.org\/10.26717\/BJSTR.2018.08.001602","journal-title":"BJSTR"},{"key":"1905_CR25","doi-asserted-by":"crossref","unstructured":"Jagota SK, Dani HM (1982) A New Calorimetric Technique for the Estimation of Vitamin C Using Folin Phenol Reagent","DOI":"10.1016\/0003-2697(82)90162-2"},{"key":"1905_CR27","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2024.e26862","volume":"10","author":"Z Ji","year":"2024","unstructured":"Ji Z, Deng W, Chen D et al (2024) Recent understanding of the mechanisms of the biological activities of hesperidin and hesperetin and their therapeutic effects on diseases. Heliyon 10:e26862. https:\/\/doi.org\/10.1016\/j.heliyon.2024.e26862","journal-title":"Heliyon"},{"key":"1905_CR28","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2021.627328","volume":"11","author":"Q Jiang","year":"2021","unstructured":"Jiang Q, Zhao Y, Shui Y et al (2021) Interactions between neutrophils and periodontal pathogens in late-onset periodontitis. Front Cell Infect Microbiol 11:627328. https:\/\/doi.org\/10.3389\/fcimb.2021.627328","journal-title":"Front Cell Infect Microbiol"},{"key":"1905_CR29","doi-asserted-by":"publisher","first-page":"20160030","DOI":"10.1515\/jcim-2016-0030","volume":"14","author":"B Khettal","year":"2017","unstructured":"Khettal B, Kadri N, Tighilet K et al (2017) Phenolic compounds from Citrus leaves: antioxidant activity and enzymatic browning inhibition. J Complement Integr Med 14:20160030. https:\/\/doi.org\/10.1515\/jcim-2016-0030","journal-title":"J Complement Integr Med"},{"key":"1905_CR30","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2016\/7517928","volume":"2016","author":"S Klangprapan","year":"2016","unstructured":"Klangprapan S, Chaiyarit P, Hormdee D et al (2016) Salivary myeloperoxidase, assessed by 3,3\u2032-diaminobenzidine colorimetry, can differentiate periodontal patients from nonperiodontal subjects. Enzyme Res 2016:1\u20136. https:\/\/doi.org\/10.1155\/2016\/7517928","journal-title":"Enzyme Res"},{"key":"1905_CR31","first-page":"464","volume-title":"Methods in Enzymology","author":"RL Levine","year":"1990","unstructured":"Levine RL, Garland D, Oliver CN et al (1990) [49] Determination of carbonyl content in oxidatively modified proteins. Methods in Enzymology. Elsevier, Amsterdam, pp 464\u2013478"},{"key":"1905_CR32","doi-asserted-by":"publisher","first-page":"613","DOI":"10.1080\/10408398.2014.906382","volume":"57","author":"C Li","year":"2017","unstructured":"Li C, Schluesener H (2017) Health-promoting effects of the citrus flavanone hesperidin. Crit Rev Food Sci Nutr 57:613\u2013631. https:\/\/doi.org\/10.1080\/10408398.2014.906382","journal-title":"Crit Rev Food Sci Nutr"},{"key":"1905_CR33","doi-asserted-by":"publisher","first-page":"138","DOI":"10.1038\/s41401-019-0228-6","volume":"41","author":"Y Liu","year":"2020","unstructured":"Liu Y, Grimm M, Dai W et al (2020) CB-dock: a web server for cavity detection-guided protein\u2013ligand blind docking. Acta Pharmacol Sin 41:138\u2013144. https:\/\/doi.org\/10.1038\/s41401-019-0228-6","journal-title":"Acta Pharmacol Sin"},{"key":"1905_CR34","doi-asserted-by":"publisher","first-page":"W159","DOI":"10.1093\/nar\/gkac394","volume":"50","author":"Y Liu","year":"2022","unstructured":"Liu Y, Yang X, Gan J et al (2022) CB-dock2: improved protein\u2013ligand blind docking by integrating cavity detection, docking and homologous template fitting. Nucleic Acids Res 50:W159\u2013W164. https:\/\/doi.org\/10.1093\/nar\/gkac394","journal-title":"Nucleic Acids Res"},{"key":"1905_CR35","doi-asserted-by":"publisher","first-page":"2993","DOI":"10.3390\/jcm14092993","volume":"14","author":"L Lorente","year":"2025","unstructured":"Lorente L, Hern\u00e1ndez Marrero E, Abreu Gonz\u00e1lez P et al (2025) High salivary malondialdehyde levels are associated with periodontitis independently of other risk factors. JCM 14:2993. https:\/\/doi.org\/10.3390\/jcm14092993","journal-title":"JCM"},{"key":"1905_CR36","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1016\/S0021-9258(19)52451-6","volume":"193","author":"OliverH Lowry","year":"1951","unstructured":"Lowry OliverH, Rosebrough NiraJ, Farr AL, Randall RoseJ (1951) Protein measurement with the folin phenol reagent. J Biol Chem 193:265\u2013275. https:\/\/doi.org\/10.1016\/S0021-9258(19)52451-6","journal-title":"J Biol Chem"},{"key":"1905_CR37","doi-asserted-by":"publisher","first-page":"14","DOI":"10.3390\/futurepharmacol3010002","volume":"3","author":"K Lu","year":"2023","unstructured":"Lu K, Yip YM (2023) Therapeutic potential of bioactive flavonoids from citrus fruit peels toward obesity and diabetes mellitus. Future Pharmacol 3:14\u201337. https:\/\/doi.org\/10.3390\/futurepharmacol3010002","journal-title":"Future Pharmacol"},{"key":"1905_CR38","doi-asserted-by":"publisher","first-page":"378","DOI":"10.3390\/antiox8090378","volume":"8","author":"C Luceri","year":"2019","unstructured":"Luceri C, Bigagli E, Agostiniani S et al (2019) Analysis of oxidative stress-related markers in Crohn\u2019s disease patients at surgery and correlations with clinical findings. Antioxidants 8:378. https:\/\/doi.org\/10.3390\/antiox8090378","journal-title":"Antioxidants"},{"key":"1905_CR39","unstructured":"M\u2019Hiri N, Ioannou I, Ghoul M, Boudhrioua M (2015) Proximate chemical composition of orange peel and variation of phenols and antioxidant activity during convective air drying"},{"key":"1905_CR40","doi-asserted-by":"publisher","first-page":"586","DOI":"10.3390\/antiox12030586","volume":"12","author":"MB Madureira","year":"2023","unstructured":"Madureira MB, Concato VM, Cruz EMS et al (2023) Naringenin and hesperidin as promising alternatives for prevention and co-adjuvant therapy for breast cancer. Antioxidants 12:586. https:\/\/doi.org\/10.3390\/antiox12030586","journal-title":"Antioxidants"},{"key":"1905_CR41","doi-asserted-by":"publisher","first-page":"838","DOI":"10.1038\/sj.bjp.0707358","volume":"152","author":"E Malle","year":"2007","unstructured":"Malle E, Furtm\u00fcller PG, Sattler W, Obinger C (2007) Myeloperoxidase: a target for new drug development? Br J Pharmacol 152:838\u2013854. https:\/\/doi.org\/10.1038\/sj.bjp.0707358","journal-title":"Br J Pharmacol"},{"key":"1905_CR42","doi-asserted-by":"publisher","first-page":"s172","DOI":"10.5530\/pj.2018.6s.30","volume":"10","author":"P Malleshappa","year":"2018","unstructured":"Malleshappa P, Kumaran RC, Venkatarangaiah K, Parveen S (2018) Peels of citrus fruits: a potential source of anti-inflammatory and anti-nociceptive agents. PJ 10:s172\u2013s178. https:\/\/doi.org\/10.5530\/pj.2018.6s.30","journal-title":"PJ"},{"key":"1905_CR43","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2019\/2676307","volume":"2019","author":"M-Q Man","year":"2019","unstructured":"Man M-Q, Yang B, Elias PM (2019) Benefits of Hesperidin for Cutaneous Functions. Evid-Based Complement Alternat Med 2019:1\u201319. https:\/\/doi.org\/10.1155\/2019\/2676307","journal-title":"Evid-Based Complement Alternat Med"},{"key":"1905_CR44","doi-asserted-by":"publisher","first-page":"10389","DOI":"10.3390\/ijms241210389","volume":"24","author":"PM Maquera-Huacho","year":"2023","unstructured":"Maquera-Huacho PM, Spolidorio DP, Manthey J, Grenier D (2023) Effect of hesperidin on barrier function and reactive oxygen species production in an oral epithelial cell model, and on secretion of macrophage-derived inflammatory mediators during Porphyromonas gingivalis infection. IJMS 24:10389. https:\/\/doi.org\/10.3390\/ijms241210389","journal-title":"IJMS"},{"key":"1905_CR45","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1186\/s12865-025-00713-8","volume":"26","author":"M Matsuoka","year":"2025","unstructured":"Matsuoka M, Soria SA, Pires JR et al (2025) Natural and induced immune responses in oral cavity and saliva. BMC Immunol 26:34. https:\/\/doi.org\/10.1186\/s12865-025-00713-8","journal-title":"BMC Immunol"},{"key":"1905_CR46","doi-asserted-by":"publisher","first-page":"1847","DOI":"10.3390\/nu14091847","volume":"14","author":"K Matsuzaki","year":"2022","unstructured":"Matsuzaki K, Nakajima A, Guo Y, Ohizumi Y (2022) A narrative review of the effects of Citrus peels and extracts on human brain health and metabolism. Nutrients 14:1847. https:\/\/doi.org\/10.3390\/nu14091847","journal-title":"Nutrients"},{"key":"1905_CR47","doi-asserted-by":"publisher","first-page":"5173","DOI":"10.3390\/ijms21145173","volume":"21","author":"L Melguizo-Rodr\u00edguez","year":"2020","unstructured":"Melguizo-Rodr\u00edguez L, Costela-Ruiz VJ, Manzano-Moreno FJ et al (2020) Salivary biomarkers and their application in the diagnosis and monitoring of the most common oral pathologies. IJMS 21:5173. https:\/\/doi.org\/10.3390\/ijms21145173","journal-title":"IJMS"},{"key":"1905_CR48","doi-asserted-by":"publisher","first-page":"S1965","DOI":"10.4103\/jpbs.jpbs_440_24","volume":"16","author":"A Mohapatra","year":"2024","unstructured":"Mohapatra A, Panda A, Pattnaik N et al (2024) Guardians of oral health: antioxidants as promising allies in periodontal wellness. J Pharm Bioallied Sci 16:S1965\u2013S1967. https:\/\/doi.org\/10.4103\/jpbs.jpbs_440_24","journal-title":"J Pharm Bioallied Sci"},{"key":"1905_CR49","doi-asserted-by":"publisher","first-page":"3380","DOI":"10.3390\/ijms22073380","volume":"22","author":"IG Munteanu","year":"2021","unstructured":"Munteanu IG, Apetrei C (2021) Analytical methods used in determining antioxidant activity: a review. IJMS 22:3380. https:\/\/doi.org\/10.3390\/ijms22073380","journal-title":"IJMS"},{"key":"1905_CR50","doi-asserted-by":"publisher","first-page":"1069","DOI":"10.3390\/plants10061069","volume":"10","author":"G Nieto","year":"2021","unstructured":"Nieto G, Fern\u00e1ndez-L\u00f3pez J, P\u00e9rez-\u00c1lvarez JA et al (2021) Valorization of citrus co-products: recovery of bioactive compounds and application in meat and meat products. Plants 10:1069. https:\/\/doi.org\/10.3390\/plants10061069","journal-title":"Plants"},{"key":"1905_CR51","doi-asserted-by":"publisher","unstructured":"Oluwatoyin AE, Christina AA, Tejumade **Ujomo, Department Of Pharmacology, Therapeutics & Toxicology, College Of Medicine, University Of Lagos; **Department Of Pharmacology And Therapeutic, University Of Ibadan, Oyo State, Nigeria. (2019) Anti-inflammatory Activity of Saccharum Officinarum Linn (Poaceae) Juice in Animal Models. RJPP. https:\/\/doi.org\/10.28933\/rjpp-2019-09-2205","DOI":"10.28933\/rjpp-2019-09-2205"},{"key":"1905_CR52","doi-asserted-by":"publisher","first-page":"498","DOI":"10.3390\/antiox4030498","volume":"4","author":"O Omoba","year":"2015","unstructured":"Omoba O, Obafaye R, Salawu S et al (2015) HPLC-DAD phenolic characterization and antioxidant activities of ripe and unripe sweet orange peels. Antioxidants 4:498\u2013512. https:\/\/doi.org\/10.3390\/antiox4030498","journal-title":"Antioxidants"},{"key":"1905_CR53","doi-asserted-by":"publisher","DOI":"10.3390\/biom12050626","volume":"12","author":"ADC Ortiz","year":"2022","unstructured":"Ortiz ADC, Fideles SOM, Reis CHB et al (2022) Therapeutic effects of citrus flavonoids neohesperidin, hesperidin and its aglycone, hesperetin on bone health. Biomolecules 12:626. https:\/\/doi.org\/10.3390\/biom12050626","journal-title":"Biomolecules"},{"key":"1905_CR54","doi-asserted-by":"publisher","first-page":"376","DOI":"10.1089\/jmf.2006.010","volume":"11","author":"HS Parmar","year":"2008","unstructured":"Parmar HS, Kar A (2008) Medicinal values of fruit peels from Citrus sinensis, Punica granatum, and Musa paradisiaca with respect to alterations in tissue lipid peroxidation and serum concentration of glucose, insulin, and thyroid hormones. J Med Food 11:376\u2013381. https:\/\/doi.org\/10.1089\/jmf.2006.010","journal-title":"J Med Food"},{"key":"1905_CR55","doi-asserted-by":"publisher","first-page":"351","DOI":"10.1016\/j.jssas.2016.07.006","volume":"17","author":"S Rafiq","year":"2018","unstructured":"Rafiq S, Kaul R, Sofi SA et al (2018) Citrus peel as a source of functional ingredient: a review. J Saudi Soc Agric Sci 17:351\u2013358. https:\/\/doi.org\/10.1016\/j.jssas.2016.07.006","journal-title":"J Saudi Soc Agric Sci"},{"key":"1905_CR56","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2014\/828149","volume":"2014","author":"MA Rahman","year":"2014","unstructured":"Rahman MA, Abdullah N, Aminudin N (2014) Inhibitory Effect on In Vitro LDL Oxidation and HMG Co-A Reductase Activity of the Liquid-Liquid Partitioned Fractions of Hericium erinaceus (Bull.) Persoon (Lion\u2019s Mane Mushroom). Biomed Res Int 2014:1\u20139. https:\/\/doi.org\/10.1155\/2014\/828149","journal-title":"Biomed Res Int"},{"key":"1905_CR57","doi-asserted-by":"publisher","first-page":"280","DOI":"10.1016\/j.ejmech.2013.06.019","volume":"67","author":"D Ribeiro","year":"2013","unstructured":"Ribeiro D, Freitas M, Tom\u00e9 SM et al (2013) Modulation of human neutrophils\u2019 oxidative burst by flavonoids. Eur J Med Chem 67:280\u2013292. https:\/\/doi.org\/10.1016\/j.ejmech.2013.06.019","journal-title":"Eur J Med Chem"},{"key":"1905_CR58","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1038\/ijos.2016.23","volume":"8","author":"P Rijkschroeff","year":"2016","unstructured":"Rijkschroeff P, Jansen IDC, Van Der Weijden FA et al (2016) Oral polymorphonuclear neutrophil characteristics in relation to oral health: a cross-sectional, observational clinical study. Int J Oral Sci 8:191\u2013198. https:\/\/doi.org\/10.1038\/ijos.2016.23","journal-title":"Int J Oral Sci"},{"key":"1905_CR59","doi-asserted-by":"publisher","first-page":"513","DOI":"10.3390\/ph14060513","volume":"14","author":"A Rivera-Antonio","year":"2021","unstructured":"Rivera-Antonio A, Rosales-Hern\u00e1ndez MC, Balbuena-Rebolledo I et al (2021) Myeloperoxidase inhibitory and antioxidant activities of (E)-2-hydroxy-\u03b1-aminocinnamic acids obtained through microwave-assisted synthesis. Pharmaceuticals 14:513. https:\/\/doi.org\/10.3390\/ph14060513","journal-title":"Pharmaceuticals"},{"key":"1905_CR61","doi-asserted-by":"publisher","first-page":"43","DOI":"10.3390\/cosmetics10020043","volume":"10","author":"T Rungsang","year":"2023","unstructured":"Rungsang T, Srivilai J, Rakasawapokin P et al (2023) Assessment of antioxidant, anti-lipid peroxidation, antiglycation, anti-inflammatory and anti-tyrosinase properties of Dendrobium sulcatum Lindl. Cosmet 10:43. https:\/\/doi.org\/10.3390\/cosmetics10020043","journal-title":"Cosmet"},{"key":"1905_CR62","doi-asserted-by":"publisher","first-page":"1607","DOI":"10.3390\/biom13111607","volume":"13","author":"S Saha","year":"2023","unstructured":"Saha S, Boesch C, Maycock J et al (2023) Sweet orange juice processing by-product extracts: a caries management alternative to chlorhexidine. Biomolecules 13:1607. https:\/\/doi.org\/10.3390\/biom13111607","journal-title":"Biomolecules"},{"key":"1905_CR63","doi-asserted-by":"publisher","first-page":"239","DOI":"10.3390\/antiox11020239","volume":"11","author":"RK Saini","year":"2022","unstructured":"Saini RK, Ranjit A, Sharma K et al (2022) Bioactive compounds of citrus fruits: a review of composition and health benefits of carotenoids, flavonoids, limonoids, and terpenes. Antioxidants 11:239. https:\/\/doi.org\/10.3390\/antiox11020239","journal-title":"Antioxidants"},{"key":"1905_CR64","doi-asserted-by":"publisher","first-page":"71","DOI":"10.15586\/qas.v15i2.1256","volume":"15","author":"MK Samota","year":"2023","unstructured":"Samota MK, Kaur M, Sharma M et al (2023) Hesperidin from citrus peel waste: extraction and its health implications. Qual Assur Saf Crops Foods. 15:71\u201399. https:\/\/doi.org\/10.15586\/qas.v15i2.1256","journal-title":"Qual Assur Saf Crops Foods."},{"key":"1905_CR65","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1042\/CS20030031","volume":"105","author":"DV Sculley","year":"2003","unstructured":"Sculley DV, Langley-Evans SC (2003) Periodontal disease is associated with lower antioxidant capacity in whole saliva and evidence of increased protein oxidation. Clin Sci 105:167\u2013172. https:\/\/doi.org\/10.1042\/CS20030031","journal-title":"Clin Sci"},{"key":"1905_CR66","doi-asserted-by":"publisher","first-page":"326","DOI":"10.1016\/j.crfs.2021.05.001","volume":"4","author":"MG Shehata","year":"2021","unstructured":"Shehata MG, Awad TS, Asker D et al (2021) Antioxidant and antimicrobial activities and UPLC-ESI-MS\/MS polyphenolic profile of sweet orange peel extracts. Curr Res Food Sci 4:326\u2013335. https:\/\/doi.org\/10.1016\/j.crfs.2021.05.001","journal-title":"Curr Res Food Sci"},{"key":"1905_CR67","doi-asserted-by":"publisher","first-page":"152","DOI":"10.4103\/0972-124X.84385","volume":"15","author":"S Singh","year":"2011","unstructured":"Singh S, Acharya A, Veerendra Kumar S (2011) Myeloperoxidase staining in the diagnosis of aggressive periodontitis. J Indian Soc Periodontol 15:152. https:\/\/doi.org\/10.4103\/0972-124X.84385","journal-title":"J Indian Soc Periodontol"},{"key":"1905_CR68","doi-asserted-by":"publisher","first-page":"1053","DOI":"10.1007\/s10266-024-01043-8","volume":"113","author":"MC Valdivieso","year":"2025","unstructured":"Valdivieso MC, Ortiz L, Castillo JJ (2025) Myeloperoxidase as a biomarker in periodontal disease: electrochemical detection using printed screen graphene electrodes. Odontology 113:1053\u20131061. https:\/\/doi.org\/10.1007\/s10266-024-01043-8","journal-title":"Odontology"},{"key":"1905_CR69","doi-asserted-by":"publisher","first-page":"910","DOI":"10.3389\/fphys.2017.00910","volume":"8","author":"Y Wang","year":"2017","unstructured":"Wang Y, Andrukhov O, Rausch-Fan X (2017) Oxidative stress and antioxidant system in periodontitis. Front Physiol 8:910. https:\/\/doi.org\/10.3389\/fphys.2017.00910","journal-title":"Front Physiol"},{"key":"1905_CR70","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2021.685364","volume":"9","author":"X Wang","year":"2021","unstructured":"Wang X, Li Y, Han L et al (2021) Role of flavonoids in the treatment of iron overload. Front Cell Dev Biol 9:685364. https:\/\/doi.org\/10.3389\/fcell.2021.685364","journal-title":"Front Cell Dev Biol"},{"key":"1905_CR71","doi-asserted-by":"publisher","first-page":"6730","DOI":"10.1016\/j.sjbs.2021.07.046","volume":"28","author":"KM Yap","year":"2021","unstructured":"Yap KM, Sekar M, Wu YS et al (2021) Hesperidin and its aglycone hesperetin in breast cancer therapy: a review of recent developments and future prospects. Saudi J Biol Sci 28:6730\u20136747. https:\/\/doi.org\/10.1016\/j.sjbs.2021.07.046","journal-title":"Saudi J Biol Sci"},{"key":"1905_CR72","doi-asserted-by":"publisher","first-page":"200","DOI":"10.1016\/j.phymed.2018.08.002","volume":"55","author":"M Yousefian","year":"2019","unstructured":"Yousefian M, Shakour N, Hosseinzadeh H et al (2019) The natural phenolic compounds as modulators of NADPH oxidases in hypertension. Phytomedicine 55:200\u2013213. https:\/\/doi.org\/10.1016\/j.phymed.2018.08.002","journal-title":"Phytomedicine"}],"container-title":["Inflammopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10787-025-01905-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10787-025-01905-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10787-025-01905-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,17]],"date-time":"2025-09-17T04:14:11Z","timestamp":1758082451000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10787-025-01905-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9]]},"references-count":68,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2025,9]]}},"alternative-id":["1905"],"URL":"https:\/\/doi.org\/10.1007\/s10787-025-01905-9","relation":{},"ISSN":["0925-4692","1568-5608"],"issn-type":[{"value":"0925-4692","type":"print"},{"value":"1568-5608","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,9]]},"assertion":[{"value":"22 July 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 August 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 September 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare that there are no conflicts of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"All experiments were conducted in accordance with ethical principles of the Declaration of Helsinki and were approved by the Ethics Committee of Badji Mokhtar University of Annaba (Algeria), under protocol code\u00a0UBMA-2024\u2013031.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}}]}}