{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T22:10:52Z","timestamp":1790633452498,"version":"4.1.0"},"reference-count":100,"publisher":"Springer Science and Business Media LLC","issue":"12","license":[{"start":{"date-parts":[[2025,11,8]],"date-time":"2025-11-08T00:00:00Z","timestamp":1762560000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,11,8]],"date-time":"2025-11-08T00:00:00Z","timestamp":1762560000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Inflammopharmacol"],"published-print":{"date-parts":[[2025,12]]},"DOI":"10.1007\/s10787-025-01944-2","type":"journal-article","created":{"date-parts":[[2025,11,8]],"date-time":"2025-11-08T06:10:30Z","timestamp":1762582230000},"page":"7255-7268","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["The promise of stem cell therapies for cellular recovery after stroke"],"prefix":"10.1007","volume":"33","author":[{"given":"Heena","family":"Khan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kavya","family":"Singh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nirbhay Kumar","family":"Prabhakar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amarjot Kaur","family":"Grewal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2979-1590","authenticated-orcid":false,"given":"Thakur Gurjeet","family":"Singh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,11,8]]},"reference":[{"key":"1944_CR2","doi-asserted-by":"publisher","first-page":"601","DOI":"10.1161\/strokeaha.119.026589","volume":"51","author":"T Abe","year":"2020","unstructured":"Abe T, Aburakawa D, Niizuma K, Iwabuchi N, Kajitani T, Wakao S et al (2020) Intravenously transplanted human multilineage-differentiating stress-enduring cells afford brain repair in a mouse lacunar stroke model. Stroke 51:601\u2013611. https:\/\/doi.org\/10.1161\/strokeaha.119.026589","journal-title":"Stroke"},{"issue":"2","key":"1944_CR3","doi-asserted-by":"publisher","first-page":"206","DOI":"10.1007\/s12035-010-8100-1","volume":"41","author":"RM Adibhatla","year":"2010","unstructured":"Adibhatla RM, Hatcher JF (2010) Protection by D609 through cell-cycle regulation after stroke. Mol Neurobiol 41(2):206\u2013217","journal-title":"Mol Neurobiol"},{"issue":"5","key":"1944_CR4","doi-asserted-by":"publisher","first-page":"1696","DOI":"10.1046\/j.1460-9568.2000.00067.x","volume":"12","author":"JM Auerbach","year":"2000","unstructured":"Auerbach JM, Eiden MV, McKay RDG (2000) Transplanted CNS stem cells form functional synapses in vivo. Eur J Neurosci 12(5):1696\u20131704. https:\/\/doi.org\/10.1046\/j.1460-9568.2000.00067.x","journal-title":"Eur J Neurosci"},{"key":"1944_CR5","doi-asserted-by":"publisher","DOI":"10.3171\/2016.2.FOCUS15637","volume":"40","author":"TD Azad","year":"2016","unstructured":"Azad TD, Veeravagu A, Steinberg GK (2016) Neurorestoration after stroke. Neurosurg Focus 40:E2","journal-title":"Neurosurg Focus"},{"issue":"7","key":"1944_CR6","doi-asserted-by":"publisher","first-page":"3211","DOI":"10.1016\/j.transproceed.2005.07.007","volume":"37","author":"A Behzad-Behbahani","year":"2005","unstructured":"Behzad-Behbahani A, Pouransari R, Tabei S, Rahiminejad M, Robati M, Yaghobi R et al (2005) Risk of viral transmission via bone marrow progenitor cells versus umbilical cord blood hematopoietic stem cells in bone marrow transplantation. Transplant Proc 37(7):3211\u20133212. https:\/\/doi.org\/10.1016\/j.transproceed.2005.07.007","journal-title":"Transplant Proc"},{"issue":"5","key":"1944_CR7","doi-asserted-by":"publisher","first-page":"899","DOI":"10.3174\/ajnr.A5586","volume":"39","author":"V Bhatia","year":"2018","unstructured":"Bhatia V, Gupta V, Khurana D, Sharma RR, Khandelwal N (2018) Randomized assessment of the safety and efficacy of intra-arterial infusion of autologous stem cells in subacute ischemic stroke. Am J Neuroradiol 39(5):899\u2013904","journal-title":"Am J Neuroradiol"},{"issue":"1","key":"1944_CR8","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s13287-018-0913-2","volume":"9","author":"AC Boese","year":"2018","unstructured":"Boese AC, Le QS, Pham D, Hamblin MH, Lee JP (2018a) Neural stem cell therapy for subacute and chronic ischemic stroke. Stem Cell Res Ther 9(1):1\u20137","journal-title":"Stem Cell Res Ther"},{"key":"1944_CR9","doi-asserted-by":"publisher","first-page":"154","DOI":"10.1186\/s13287-018-0913-2","volume":"9","author":"AC Boese","year":"2018","unstructured":"Boese AC, Le QE, Pham D, Hamblin MH, Lee JP (2018b) Neural stem cell therapy for subacute and chronic ischemic stroke. Stem Cell Res Ther 9:154. https:\/\/doi.org\/10.1186\/s13287-018-0913-2","journal-title":"Stem Cell Res Ther"},{"issue":"5497","key":"1944_CR10","doi-asserted-by":"publisher","first-page":"1775","DOI":"10.1126\/science.290.5497.1775","volume":"290","author":"TR Brazelton","year":"2000","unstructured":"Brazelton TR, Rossi FMV, Keshet GI, Blau HM (2000) From marrow to brain: expression of neuronal phenotypes in adult mice. Science 290(5497):1775. https:\/\/doi.org\/10.1126\/science.290.5497.1775","journal-title":"Science"},{"issue":"1","key":"1944_CR11","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1016\/j.stem.2011.06.008","volume":"9","author":"AI Caplan","year":"2011","unstructured":"Caplan AI, Correa D (2011) The MSC: an injury drugstore. Cell Stem Cell 9(1):11\u201315. https:\/\/doi.org\/10.1016\/j.stem.2011.06.008","journal-title":"Cell Stem Cell"},{"issue":"11","key":"1944_CR12","doi-asserted-by":"publisher","first-page":"2682","DOI":"10.1161\/hs1101.098367","volume":"32","author":"J Chen","year":"2001","unstructured":"Chen J, Sanberg PR, Li Yi, Wang L, Lu M, Willing AE, Sanchez-Ramos J, Chopp M (2001) Intravenous administration of human umbilical cord blood reduces behavioral deficits after stroke in rats. Stroke 32(11):2682\u20132688. https:\/\/doi.org\/10.1161\/hs1101.098367","journal-title":"Stroke"},{"issue":"7","key":"1944_CR123","doi-asserted-by":"publisher","first-page":"1128","DOI":"10.1161\/hs1101.098367","volume":"23","author":"Q Chen","year":"2016","unstructured":"Chen Q, Shou P, Zheng C, Jiang M, Cao G, Yang Q, Cao J, Xie N, Velletri T, Zhang X, Xu C (2016) Fate decision of mesenchymal stem cells: adipocytes or osteoblasts?. Cell Death Differ 23(7):1128\u201339","journal-title":"Cell Death Differ"},{"issue":"7","key":"1944_CR14","doi-asserted-by":"publisher","first-page":"1282","DOI":"10.1038\/mt.2009.104","volume":"17","author":"MM Daadi","year":"2009","unstructured":"Daadi MM, Li Z, Arac A, Grueter BA, Sofilos M, Malenka RC, Wu JC, Steinberg GK (2009) Molecular and magnetic resonance imaging of human embryonic stem cell-derived neural stem cell grafts in ischemic rat brain. Mol Ther 17(7):1282\u20131291. https:\/\/doi.org\/10.1038\/mt.2009.104","journal-title":"Mol Ther"},{"issue":"1","key":"1944_CR15","doi-asserted-by":"publisher","first-page":"178","DOI":"10.1186\/s12974-019-1571-8","volume":"16","author":"S Dabrowska","year":"2019","unstructured":"Dabrowska S, Andrzejewska A, Lukomska B et al (2019) Neuroinfammation as a target for treatment of stroke using mesenchymal stem cells and extracellular vesicles. J Neuroinfammation 16(1):178. https:\/\/doi.org\/10.1186\/s12974-019-1571-8","journal-title":"J Neuroinfammation"},{"key":"1944_CR16","doi-asserted-by":"publisher","first-page":"220","DOI":"10.3390\/jcm2040220","volume":"2","author":"T Dailey","year":"2013","unstructured":"Dailey T, Metcalf C, Mosley YI et al (2013) An update on translating stem cell therapy for stroke from bench to bedside. J Clin Med 2:220\u2013241","journal-title":"J Clin Med"},{"issue":"1","key":"1944_CR18","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1038\/jcbfm.2010.81","volume":"31","author":"V Darsalia","year":"2011","unstructured":"Darsalia V, Allison SJ, Cusulin C, Monni E, Kuzdas D, Kallur T, Lindvall O, Kokaia Z (2011) Cell number and timing of transplantation determine survival of human neural stem cell grafts in stroke-damaged rat brain. J Cereb Blood Flow Metab 31(1):235\u2013242","journal-title":"J Cereb Blood Flow Metab"},{"key":"1944_CR19","doi-asserted-by":"publisher","first-page":"322","DOI":"10.1097\/WCO.0b013e328352ec45","volume":"25","author":"D De Feo","year":"2012","unstructured":"De Feo D, Merlini A, Laterza C, Martino G (2012) Neural stem cell transplantation in central nervous system disorders: from cell replacement to neuroprotection. Curr Opin Neurol 25:322\u2013333","journal-title":"Curr Opin Neurol"},{"key":"1944_CR21","doi-asserted-by":"publisher","first-page":"849","DOI":"10.3727\/096368916x690881","volume":"25","author":"M Dezawa","year":"2016","unstructured":"Dezawa M (2016) Muse cells provide the pluripotency of mesenchymal stem cells: direct contribution of muse cells to tissue regeneration. Cell Transplant 25:849\u2013861. https:\/\/doi.org\/10.3727\/096368916x690881","journal-title":"Cell Transplant"},{"issue":"10","key":"1944_CR23","doi-asserted-by":"publisher","first-page":"1131","DOI":"10.5966\/sctm.2015-0078","volume":"4","author":"TR Doeppner","year":"2015","unstructured":"Doeppner TR, Herz J, G\u00f6rgens A, Schlechter J, Ludwig AK, Radtke S, de Miroschedji K, Horn PA, Giebel B, Hermann DM (2015) Extracellular vesicles improve post-stroke neuroregeneration and prevent postischemic immunosuppression. Stem Cells Transl Med 4(10):1131\u20131143","journal-title":"Stem Cells Transl Med"},{"key":"1944_CR24","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1186\/scrt292","volume":"4","author":"D Drury-Stewart","year":"2013","unstructured":"Drury-Stewart D, Song M, Mohamad O, Guo Y, Gu X, Chen D et al (2013) Highly efficient differentiation of neural precursors from human embryonic stem cells and benefits of transplantation after ischemic stroke in mice. Stem Cell Res Ther 4:93. https:\/\/doi.org\/10.1186\/scrt292","journal-title":"Stem Cell Res Ther"},{"issue":"1_suppl","key":"1944_CR25","doi-asserted-by":"publisher","first-page":"13","DOI":"10.3727\/096368912X612512","volume":"1","author":"AG Friedrich Mauricio","year":"2012","unstructured":"Friedrich Mauricio AG, Martins MP, Araujo MD, Charles K, Leonardo V, Bernardo G, Raupp EF et al (2012) Intra-arterial infusion of autologous bone marrow mononuclear cells in patients with moderate to severe middle cerebral artery acute ischemic stroke. Cell Transplant 1(1_suppl):13\u201321. https:\/\/doi.org\/10.3727\/096368912X612512","journal-title":"Cell Transplant"},{"issue":"4","key":"1944_CR26","doi-asserted-by":"publisher","first-page":"435","DOI":"10.1177\/096368979900800415","volume":"8","author":"A Fukunaga","year":"1999","unstructured":"Fukunaga A, Uchida K, Hara K, Kuroshima Y, Kawase T (1999) Differentiation and angiogenesis of central nervous system stem cells implanted with mesenchyme into ischemic rat brain. Cell Transplant 8(4):435\u2013441. https:\/\/doi.org\/10.1177\/096368979900800415","journal-title":"Cell Transplant"},{"issue":"1","key":"1944_CR27","first-page":"2853650","volume":"2020","author":"L Gao","year":"2020","unstructured":"Gao L, Peng Y, Xu W, He P, Li T, Lu X, Chen G (2020) Progress in stem cell therapy for spinal cord injury. Stem Cells Int 2020(1):2853650","journal-title":"Stem Cells Int"},{"issue":"6","key":"1944_CR28","doi-asserted-by":"publisher","first-page":"1144","DOI":"10.1002\/stem.1079","volume":"30","author":"JD Glass","year":"2012","unstructured":"Glass JD, Boulis NM, Johe K, Rutkove SB, Federici T, Polak M, Kelly C, Feldman EL (2012) Lumbar intraspinal injection of neural stem cells in patients with amyotrophic lateral sclerosis: results of a phase I trial in 12 patients. Stem Cells 30(6):1144\u20131151. https:\/\/doi.org\/10.1002\/stem.1079","journal-title":"Stem Cells"},{"key":"1944_CR29","doi-asserted-by":"publisher","first-page":"947","DOI":"10.1161\/STROKEAHA.110.603902","volume":"42","author":"F Gokcay","year":"2011","unstructured":"Gokcay F, Arsava EM, Baykaner T et al (2011) Age-dependent susceptibility to infarct growth in women. Stroke 42:947\u2013951","journal-title":"Stroke"},{"key":"1944_CR30","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0064752","volume":"8","author":"S Heneidi","year":"2013","unstructured":"Heneidi S, Simerman A, Keller E, Singh P, Li X, Dumesic D et al (2013) Awakened by cellular stress: isolation and characterization of a novel population of pluripotent stem cells derived from human adipose tissue. PLoS ONE 8:e64752. https:\/\/doi.org\/10.1371\/journal.pone.0064752","journal-title":"PLoS ONE"},{"key":"1944_CR31","doi-asserted-by":"publisher","first-page":"303","DOI":"10.1080\/14653240801949994","volume":"10","author":"B Hennemann","year":"2008","unstructured":"Hennemann B, Ickenstein G, Sauerbruch S, Luecke K, Haas S, Horn M et al (2008) Mobilization of CD34+ hematopoietic cells, colony-forming cells and long-term culture-initiating cells into the peripheral blood of patients with an acute cerebral ischemic insult. Cytotherapy 10:303\u2013311. https:\/\/doi.org\/10.1080\/14653240801949994","journal-title":"Cytotherapy"},{"key":"1944_CR32","doi-asserted-by":"publisher","first-page":"94","DOI":"10.1111\/j.1365-2184.2008.00486.x","volume":"41","author":"DC Hess","year":"2008","unstructured":"Hess DC, Borlongan CV (2008) Stem cells and neurological diseases. Cell Prolif 41:94\u2013114","journal-title":"Cell Prolif"},{"issue":"5","key":"1944_CR33","doi-asserted-by":"publisher","first-page":"360","DOI":"10.1016\/S1474-4422(17)30046-7","volume":"16","author":"DC Hess","year":"2017","unstructured":"Hess DC, Wechsler LR, Clark WM, Savitz SI, Ford GA, Chiu D, Yavagal DR, Uchino K, Liebeskind DS, Auchus AP, Sen S, Sila CA, Vest JD, Mays RW (2017) Safety and efficacy of multipotent adult progenitor cells in acute ischaemic stroke (MASTERS): a randomised, double-blind, placebo-controlled, phase 2 trial. Lancet Neurol 16(5):360\u2013368. https:\/\/doi.org\/10.1016\/S1474-4422(17)30046-7","journal-title":"Lancet Neurol"},{"issue":"7","key":"1944_CR34","doi-asserted-by":"publisher","first-page":"1495","DOI":"10.1002\/jnr.21056","volume":"84","author":"Y Horita","year":"2006","unstructured":"Horita Y, Honmou O, Harada K, Houkin K, Hamada H, Kocsis JD (2006) Intravenous administration of glial cell line-derived neurotrophic factor gene modified human mesenchymal stem cells protects against injury in a cerebral ischemia model in the adult rat. J Neurosci Res 84(7):1495\u20131504. https:\/\/doi.org\/10.1002\/jnr.21056","journal-title":"J Neurosci Res"},{"key":"1944_CR35","doi-asserted-by":"crossref","unstructured":"Hourd P, Chandra A, Medcalf N, Williams DJ (2014) Regulatory challenges for the manufacture and scale-out of autologous cell therapies StemBook. Harvard Stem Cell Institute, Cambridge","DOI":"10.3824\/stembook.1.96.1"},{"key":"1944_CR36","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.brainres.2003.09.084","volume":"1007","author":"S Iihoshi","year":"2004","unstructured":"Iihoshi S, Honmou O, Houkin K, Hashi K, Kocsis JD (2004) A therapeutic window for intravenous administration of autologous bone marrow after cerebral ischemia in adult rats. Brain Res 1007:1\u20139. https:\/\/doi.org\/10.1016\/j.brainres.2003.09.084","journal-title":"Brain Res"},{"issue":"2","key":"1944_CR116","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1002\/jnr.20246","volume":"78","author":"S Ishibashi","year":"2004","unstructured":"Ishibashi S, Sakaguchi M, Kuroiwa T, Yamasaki M, Kanemura Y, Shizuko I, Shimazaki T, Onodera M, Okano H, Mizusawa H (2004) Human neural stem\/progenitor cells, expanded in long-term neurosphere culture, promote functional recovery after focal ischemia in Mongolian gerbils.  J Neurosci Res 78(2):215\u201323","journal-title":"J Neurosci Res"},{"issue":"9","key":"1944_CR37","first-page":"e5585","volume":"11","author":"JS Jayaraj","year":"2019","unstructured":"Jayaraj JS, Janapala RN, Qaseem A, Usman N, Fathima N, Kashif T, Reddy VK, Bakshi S (2019) Efficacy and safety of stem cell therapy in advanced heart failure patients: a systematic review with a meta-analysis of recent trials between 2017 and 2019. Cureus 11(9):e5585","journal-title":"Cureus"},{"key":"1944_CR38","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1016\/j.neuroscience.2011.10.043","volume":"201","author":"Y Jiang","year":"2012","unstructured":"Jiang Y, Wei N, Zhu J et al (2012) A new approach with less damage: intranasal delivery of tetracycline-inducible replication-defective herpes simplex virus type-1 vector to brain. Neuroscience 201:96\u2013104","journal-title":"Neuroscience"},{"key":"1944_CR39","doi-asserted-by":"publisher","first-page":"222","DOI":"10.1016\/j.bbr.2013.05.011","volume":"250","author":"C Jiang","year":"2013","unstructured":"Jiang C, Wang J, Yu L et al (2013a) Comparison of the therapeutic efects of bone marrow mononuclear cells and microglia for permanent cerebral ischemia. Behav Brain Res 250:222\u2013229. https:\/\/doi.org\/10.1016\/j.bbr.2013.05.011","journal-title":"Behav Brain Res"},{"issue":"12","key":"1944_CR40","doi-asserted-by":"publisher","first-page":"2291","DOI":"10.3727\/096368912X658818","volume":"22","author":"Y Jiang","year":"2013","unstructured":"Jiang Y, Zhu W, Zhu J, Wu L, Xu G, Liu X (2013b) Feasibility of delivering mesenchymal stem cells via catheter to the proximal end of the lesion artery in patients with stroke in the territory of the middle cerebral artery. Cell Transplant 22(12):2291\u20132298","journal-title":"Cell Transplant"},{"issue":"1\u20132","key":"1944_CR41","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1016\/j.jneuroim.2009.09.003","volume":"189","author":"C Jieli","year":"2001","unstructured":"Jieli C, Yi L, Lei W, Mei L, Xuehui Z, Michael C (2001) Therapeutic benefit of intracerebral transplantation of bone marrow stromal cells after cerebral ischemia in rats. J Neurol Sci 189(1\u20132):49\u201357. https:\/\/doi.org\/10.1016\/j.jneuroim.2009.09.003","journal-title":"J Neurol Sci"},{"issue":"10046","key":"1944_CR43","doi-asserted-by":"publisher","first-page":"787","DOI":"10.1016\/S0140-6736(16)30513-X","volume":"388","author":"D Kalladka","year":"2016","unstructured":"Kalladka D, Sinden J, Pollock K, Haig C, McLean J, Smith W, McConnachie A, Santosh C, Bath PM, Dunn L, Muir KW (2016) Human neural stem cells in patients with chronic ischaemic stroke (PISCES): a phase 1, first-in-man study. Lancet 388(10046):787\u2013796","journal-title":"Lancet"},{"issue":"19","key":"1944_CR44","doi-asserted-by":"publisher","first-page":"7380","DOI":"10.3390\/ijms21197380","volume":"21","author":"M Kawabori","year":"2020","unstructured":"Kawabori M, Shichinohe H, Kuroda S, Houkin K (2020) Clinical trials of stem cell therapy for cerebral ischemic stroke. Int J Mol Sci 21(19):7380","journal-title":"Int J Mol Sci"},{"key":"1944_CR46","doi-asserted-by":"publisher","first-page":"1167","DOI":"10.1007\/s10072-017-2938-1","volume":"38","author":"SE Khoshnam","year":"2017","unstructured":"Khoshnam SE, Winlow W, Farzaneh M, Farbood Y, Moghaddam HF (2017) Pathogenic mechanisms following ischemic stroke. Neurol Sci 38:1167\u20131186","journal-title":"Neurol Sci"},{"issue":"2","key":"1944_CR47","doi-asserted-by":"publisher","first-page":"112","DOI":"10.1016\/j.critrevonc.2010.07.009","volume":"79","author":"Y-J Kim","year":"2011","unstructured":"Kim Y-J, Broxmeyer HE (2011) Immune regulatory cells in umbilical cord blood and their potential roles in transplantation tolerance. Crit Rev Oncol Hematol 79(2):112\u2013126. https:\/\/doi.org\/10.1016\/j.critrevonc.2010.07.009","journal-title":"Crit Rev Oncol Hematol"},{"issue":"23","key":"1944_CR48","doi-asserted-by":"publisher","first-page":"9614","DOI":"10.1158\/0008-5472.CAN-08-0451","volume":"68","author":"SM Kim","year":"2008","unstructured":"Kim SM, Lim JY, Park SI, Jeong CH, Oh JH, Jeong M, Oh W, Park SH, Sung YC, Jeun SS (2008) Gene therapy using TRAIL-secreting human umbilical cord blood\u2013derived mesenchymal stem cells against intracranial glioma. Can Res 68(23):9614\u20139623","journal-title":"Can Res"},{"issue":"4","key":"1944_CR49","doi-asserted-by":"publisher","first-page":"1272","DOI":"10.3390\/ijms21041272","volume":"21","author":"H Kim","year":"2020","unstructured":"Kim H, Na DL, Lee NK, Kim AR, Lee S, Jang H (2020) Intrathecal injection in a rat model: a potential route to deliver human Wharton\u2019s jelly-derived mesenchymal stem cells into the brain. Int J Mol Sci 21(4):1272","journal-title":"Int J Mol Sci"},{"key":"1944_CR50","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1007\/s12975-016-0460-z","volume":"8","author":"S-H Koh","year":"2017","unstructured":"Koh S-H, Park H-H (2017) Neurogenesis in stroke recovery. Transl Stroke Res 8:3\u201313","journal-title":"Transl Stroke Res"},{"issue":"1","key":"1944_CR51","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0000156","volume":"2","author":"HJ Lee","year":"2007","unstructured":"Lee HJ, Kim KS, Park IH, Kim SU (2007) Human neural stem cells over-expressing VEGF provide neuroprotection, angiogenesis and functional recovery in mouse stroke model. PLoS ONE 2(1):e156. https:\/\/doi.org\/10.1371\/journal.pone.0000156","journal-title":"PLoS ONE"},{"key":"1944_CR126","doi-asserted-by":"crossref","unstructured":"Lee DY, Lee SE, Kwon DH, Nithiyanandam S, Lee MH, Hwang JS, Basith S, Ahn JH, Shin TH, Lee G (2021) Strategies to Improve the Quality and Freshness of Human Bone Marrow\u2010Derived Mesenchymal Stem Cells for Neurological Diseases. Stem Cells Int 2021(1):8444599","DOI":"10.1155\/2021\/8444599"},{"key":"1944_CR53","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.56.12.1666","author":"Y Li","year":"2001","unstructured":"Li Y, Chen J, Wang L, Lu M, Chopp M (2001) Treatment of stroke in rat with intracarotid administration of marrow stromal cells. Neurology. https:\/\/doi.org\/10.1212\/WNL.56.12.1666","journal-title":"Neurology"},{"issue":"3","key":"1944_CR54","doi-asserted-by":"publisher","first-page":"407","DOI":"10.1002\/glia.20126","volume":"49","author":"Yi Li","year":"2005","unstructured":"Li Yi, Chen J, Zhang CL, Wang L, Lu D, Katakowski M, Gao Qi et al (2005) Gliosis and brain remodeling after treatment of stroke in rats with marrow stromal cells. Glia 49(3):407\u2013417. https:\/\/doi.org\/10.1002\/glia.20126","journal-title":"Glia"},{"key":"1944_CR55","doi-asserted-by":"publisher","first-page":"653","DOI":"10.1038\/jcbfm.2009.238","volume":"30","author":"L Li","year":"2010","unstructured":"Li L, Jiang Q, Ding G et al (2010) Effects of administration route on migration and distribution of neural progenitor cells transplanted into rats with focal cerebral ischemia, an MRI study. J Cereb Blood Flow Metab 30:653\u2013662","journal-title":"J Cereb Blood Flow Metab"},{"issue":"15","key":"1944_CR56","first-page":"10","volume":"9","author":"W Li","year":"2021","unstructured":"Li W, Shi L, Hu B, Hong Y, Zhang H, Li X, Zhang Y (2021) Mesenchymal stem cell-based therapy for stroke: current understanding and challenges. Front Cell Neurosci 9(15):10","journal-title":"Front Cell Neurosci"},{"issue":"2","key":"1944_CR58","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1038\/s41422-020-0385-7","volume":"31","author":"C Liang","year":"2021","unstructured":"Liang C, Liu Z, Song M, Li W, Wu Z, Wang Z, Wang Q, Wang S, Yan K, Sun L, Hishida T (2021) Stabilization of heterochromatin by CLOCK promotes stem cell rejuvenation and cartilage regeneration. Cell Res 31(2):187\u2013205","journal-title":"Cell Res"},{"key":"1944_CR59","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/scrt79","volume":"2","author":"JY Lim","year":"2011","unstructured":"Lim JY, Jeong CH, Jun JA, Kim SM, Ryu CH, Hou Y, Oh W, Chang JW, Jeun SS (2011) Therapeutic effects of human umbilical cord blood-derived mesenchymal stem cells after intrathecal administration by lumbar puncture in a rat model of cerebral ischemia. Stem Cell Res Ther 2:1\u20133","journal-title":"Stem Cell Res Ther"},{"key":"1944_CR61","doi-asserted-by":"publisher","first-page":"804","DOI":"10.1016\/j.nbd.2011.11.004","volume":"45","author":"Z Liu","year":"2012","unstructured":"Liu Z, Li Y, Zhang L et al (2012) Subacute intranasal administration of tissue plasminogen activator increases functional recovery and axonal remodeling after stroke in rats. Neurobiol Dis 45:804\u2013809","journal-title":"Neurobiol Dis"},{"issue":"7272","key":"1944_CR64","doi-asserted-by":"publisher","first-page":"433","DOI":"10.1038\/nature08602","volume":"462","author":"MP Lutolf","year":"2009","unstructured":"Lutolf MP, Gilbert PM, Blau HM (2009) Designing materials to direct stem-cell fate. Nature 462(7272):433\u2013441","journal-title":"Nature"},{"key":"1944_CR65","doi-asserted-by":"publisher","first-page":"392","DOI":"10.1016\/j.jcyt.2014.12.004","volume":"17","author":"T M\u00e4kel\u00e4","year":"2015","unstructured":"M\u00e4kel\u00e4 T, Takalo R, Arvola O et al (2015) Safety and biodistribution study of bone marrow\u2013derived mesenchymal stromal cells and mononuclear cells and the impact of the administration route in an intact porcine model. Cytotherapy 17:392\u2013402","journal-title":"Cytotherapy"},{"key":"1944_CR67","doi-asserted-by":"publisher","first-page":"S207","DOI":"10.1212\/WNL.0b013e31826959d2","volume":"79","author":"V Misra","year":"2012","unstructured":"Misra V, Ritchie MM, Stone LL, Low WC, Janardhan V (2012) Stem cell therapy in ischemic stroke role of IV and intra-arterial therapy. Neurology 79:S207\u2013S212","journal-title":"Neurology"},{"key":"1944_CR69","doi-asserted-by":"publisher","first-page":"661","DOI":"10.1016\/j.cell.2008.02.008","volume":"132","author":"CE Murry","year":"2008","unstructured":"Murry CE, Keller G (2008) Differentiation of embryonic stem cells to clinically relevant populations: lessons from embryonic development. Cell 132:661\u2013680. https:\/\/doi.org\/10.1016\/j.cell.2008.02.008","journal-title":"Cell"},{"issue":"6","key":"1944_CR125","doi-asserted-by":"publisher","first-page":"2287","DOI":"10.1111\/j.0953-816X.2004.03314.x","volume":"48","author":"C Nan","year":"2016","unstructured":"Nan C, Guo L, Zhao Z, Ma S, Liu J, Yan D, Song G, Liu H (2016) Tetramethylpyrazine induces differentiation of human umbilical cordderived mesenchymal stem cells into neuron-like cells in vitro. Int J Oncol 48(6):2287\u201394","journal-title":"Int J Oncol"},{"issue":"9","key":"1944_CR70","doi-asserted-by":"publisher","first-page":"2388","DOI":"10.1111\/j.0953-816X.2004.03314.x","volume":"19","author":"IV Nosrat","year":"2004","unstructured":"Nosrat IV, Smith CA, Mullally P, Olson L, Nosrat CA (2004) Dental pulp cells provide neurotrophic support for dopaminergic neurons and differentiate into neurons in vitro; implications for tissue engineering and repair in the nervous system. Eur J Neurosci 19(9):2388\u20132398. https:\/\/doi.org\/10.1111\/j.0953-816X.2004.03314.x","journal-title":"Eur J Neurosci"},{"key":"1944_CR71","doi-asserted-by":"publisher","DOI":"10.1242\/dev.156059","volume":"146","author":"K Obernier","year":"2019","unstructured":"Obernier K, Alvarez-Buylla A (2019) Neural stem cells: origin, heterogeneity and regulation in the adult mammalian brain. Development 146:dev156059. https:\/\/doi.org\/10.1242\/dev.156059","journal-title":"Development"},{"issue":"6","key":"1944_CR72","doi-asserted-by":"publisher","first-page":"1120","DOI":"10.1002\/stem.1104","volume":"30","author":"K Oki","year":"2012","unstructured":"Oki K, Tatarishvili J, Wood J, Koch P, Wattananit S, Mine Y, Monni E et al (2012) Human-induced pluripotent stem cells form functional neurons and improve recovery after grafting in stroke-damaged brain. Stem Cells 30(6):1120\u20131133. https:\/\/doi.org\/10.1002\/stem.1104","journal-title":"Stem Cells"},{"key":"1944_CR73","doi-asserted-by":"publisher","first-page":"148","DOI":"10.3389\/fneur.2020.00148","volume":"11","author":"L Ottoboni","year":"2020","unstructured":"Ottoboni L, von Wunster B, Martino G (2020) Therapeutic plasticity of neural stem cells. Front Neurol 11:148. https:\/\/doi.org\/10.3389\/fneur.2020.00148","journal-title":"Front Neurol"},{"issue":"1","key":"1944_CR117","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1016\/j.expneurol.2005.12.011","volume":"199","author":"K Pollock","year":"2006","unstructured":"Pollock K, Stroemer P, Patel S, Stevanato L, Hope A, Miljan E, Dong Z, Hodges H, Price J, Sinden JD (2006) A conditionally immortal clonal stem cell line from human cortical neuroepithelium for the treatment of ischemic stroke. Exp Neurol 199(1):143\u201355","journal-title":"Exp Neurol"},{"key":"1944_CR74","doi-asserted-by":"publisher","first-page":"772","DOI":"10.2741\/4336","volume":"20","author":"J Pei","year":"2015","unstructured":"Pei J, You X, Fu Q (2015) Inflammation in the pathogenesis of ischemic stroke. Front Biosci 20:772\u2013783","journal-title":"Front Biosci"},{"issue":"4","key":"1944_CR75","doi-asserted-by":"publisher","first-page":"355","DOI":"10.1111\/j.1440-1789.2007.00792.x","volume":"27","author":"R Qu","year":"2007","unstructured":"Qu R, Li Yi, Gao Qi, Shen L, Zhang J, Liu Z, Chen X, Chopp M (2007) Neurotrophic and growth factor gene expression profiling of mouse bone marrow stromal cells induced by ischemic brain extracts. Neuropathology 27(4):355\u2013363. https:\/\/doi.org\/10.1111\/j.1440-1789.2007.00792.x","journal-title":"Neuropathology"},{"key":"1944_CR76","doi-asserted-by":"publisher","first-page":"126","DOI":"10.1007\/s10517-005-0229-y","volume":"139","author":"SS Rabinovich","year":"2005","unstructured":"Rabinovich SS, Seledtsov VI, Banul NV et al (2005) Cell therapy of brain stroke. Bull Exp Biol Med 139:126\u2013128","journal-title":"Bull Exp Biol Med"},{"key":"1944_CR77","doi-asserted-by":"publisher","first-page":"378","DOI":"10.1007\/s12975-016-0482-6","volume":"7","author":"B Rodr\u00edguez-Frutos","year":"2016","unstructured":"Rodr\u00edguez-Frutos B, Otero-Ortega L, Guti\u00e9rrez-Fern\u00e1ndez M, Fuentes B, Ramos-Cejudo J, D\u00edez-Tejedor E (2016) Stem cell therapy and administration routes after stroke. Transl Stroke Res 7:378\u2013387","journal-title":"Transl Stroke Res"},{"key":"1944_CR78","doi-asserted-by":"publisher","first-page":"2449","DOI":"10.3727\/096368914x679354","volume":"24","author":"S Rosenblum","year":"2015","unstructured":"Rosenblum S, Smith TN, Wang N, Chua JY, Westbroek E, Wang K et al (2015) BDNF pretreatment of human embryonic-derived neural stem cells improves cell survival and functional recovery after transplantation in hypoxic-ischemic stroke. Cell Transplant 24:2449\u20132461 https:\/\/doi.org\/10.3727\/096368914x679354","journal-title":"Cell Transplant"},{"key":"1944_CR80","doi-asserted-by":"publisher","first-page":"80","DOI":"10.1172\/jci59251","volume":"122","author":"K Sakai","year":"2012","unstructured":"Sakai K, Yamamoto A, Matsubara K, Nakamura S, Naruse M, Yamagata M et al (2012) Human dental pulp-derived stem cells promote locomotor recovery after complete transection of the rat spinal cord by multiple neuro-regenerative mechanisms. J Clin Invest 122:80\u201390. https:\/\/doi.org\/10.1172\/jci59251","journal-title":"J Clin Invest"},{"issue":"4","key":"1944_CR121","doi-asserted-by":"publisher","first-page":"356","DOI":"10.1007\/s12975-017-0580-0","volume":"9","author":"D Sarmah","year":"2018","unstructured":"Sarmah D, Kaur H, Saraf J, Pravalika K, Goswami A, Kalia K, Borah A, Wang X, Dave KR, Yavagal DR, Bhattacharya P (2018) Getting closer to an effective intervention of ischemic stroke: the big promise of stem cell. Transl Stroke Res  9(4):356\u201374","journal-title":"Transl Stroke Res"},{"issue":"4","key":"1944_CR82","doi-asserted-by":"publisher","first-page":"406","DOI":"10.1602\/neurorx.1.4.406","volume":"1","author":"SI Savitz","year":"2004","unstructured":"Savitz SI, Dinsmore JH, Wechsler LR, Rosenbaum DM, Caplan LR (2004) Cell therapy for stroke. NeuroRx 1(4):406\u2013414","journal-title":"NeuroRx"},{"key":"1944_CR83","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1159\/000086518","volume":"20","author":"SI Savitz","year":"2005","unstructured":"Savitz SI, Dinsmore J, Wu J, Henderson GV, Stieg P, Caplan LR (2005) Neurotransplantation of fetal porcine cells in patients with basal ganglia infarcts: a preliminary safety and feasibility study. Cerebrovasc Dis 20:101\u2013107","journal-title":"Cerebrovasc Dis"},{"issue":"1","key":"1944_CR84","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1002\/ana.22458","volume":"70","author":"SI Savitz","year":"2011","unstructured":"Savitz SI, Misra V, Kasam M, Juneja H, Cox CS Jr, Alderman S, Aisiku I, Kar S, Gee A, Grotta JC (2011) Intravenous autologous bone marrow mononuclear cells for ischemic stroke. Ann Neurol 70(1):59\u201369","journal-title":"Ann Neurol"},{"issue":"2","key":"1944_CR85","doi-asserted-by":"publisher","first-page":"192","DOI":"10.1161\/CIRCULATIONAHA.117.030659","volume":"139","author":"SI Savitz","year":"2019","unstructured":"Savitz SI, Yavagal D, Rappard G, Likosky W, Rutledge N, Graffagnino C, Alderazi Y et al (2019) A phase 2 randomized, sham-controlled trial of internal carotid artery infusion of autologous bone marrow-derived ALD-401 cells in patients with recent stable ischemic stroke (RECOVER-stroke). Circulation 139(2):192\u2013205. https:\/\/doi.org\/10.1161\/CIRCULATIONAHA.117.030659","journal-title":"Circulation"},{"issue":"2","key":"1944_CR86","doi-asserted-by":"publisher","first-page":"393","DOI":"10.1016\/j.neuroscience.2005.08.092","volume":"137","author":"LH Shen","year":"2006","unstructured":"Shen LH, Li Y, Chen J, Zhang J, Vanguri P, Borneman J, Chopp M (2006) Intracarotid transplantation of bone marrow stromal cells increases axon-myelin remodeling after stroke. Neuroscience 137(2):393\u2013399. https:\/\/doi.org\/10.1016\/j.neuroscience.2005.08.092","journal-title":"Neuroscience"},{"key":"1944_CR87","doi-asserted-by":"publisher","first-page":"1204","DOI":"10.5966\/sctm.2015-0270","volume":"5","author":"AK Shetty","year":"2016","unstructured":"Shetty AK, Hattiangady B (2016) Grafted subventricular zone neural stem cells display robust engraftment and similar differentiation properties and form new neurogenic niches in the young and aged hippocampus. Stem Cells Transl Med 5:1204\u20131215. https:\/\/doi.org\/10.5966\/sctm.2015-0270","journal-title":"Stem Cells Transl Med"},{"key":"1944_CR88","doi-asserted-by":"publisher","DOI":"10.1177\/0963689719836763","author":"ML Shiao","year":"2019","unstructured":"Shiao ML, Ce Y, Crane AT, Voth JP, Mario J, Hocum LL, Stone NZ et al (2019) Immunomodulation with human umbilical cord blood stem cells ameliorates ischemic brain injury - a brain transcriptome profiling analysis. Cell Transplant. https:\/\/doi.org\/10.1177\/0963689719836763","journal-title":"Cell Transplant"},{"issue":"4","key":"1944_CR89","doi-asserted-by":"publisher","first-page":"785","DOI":"10.1002\/stem.1024","volume":"30","author":"J Smith Edward","year":"2012","unstructured":"Smith Edward J, Paul Stroemer R, Natalia G, Mitsuko N, Crum William R, Ellen T, Lara S, Sinden John D, Michel M (2012) Implantation site and lesion topology determine efficacy of a human neural stem cell line in a rat model of chronic stroke. Stem Cells 30(4):785\u2013796. https:\/\/doi.org\/10.1002\/stem.1024","journal-title":"Stem Cells"},{"key":"1944_CR90","doi-asserted-by":"publisher","first-page":"495","DOI":"10.1016\/j.exphem.2011.01.003","volume":"39","author":"H Sovalat","year":"2011","unstructured":"Sovalat H, Scrofani M, Eidenschenk A, Pasquet S, Rimelen V, H\u00e9non P (2011) Identification and isolation from either adult human bone marrow or G-CSF-mobilized peripheral blood of CD34(+)\/CD133(+)\/CXCR4(+)\/ lin(-)CD45(-) cells, featuring morphological, molecular, and phenotypic characteristics of very small embryonic-like (VSEL) stem cells. Exp Hematol 39:495\u2013505. https:\/\/doi.org\/10.1016\/j.exphem.2011.01.003","journal-title":"Exp Hematol"},{"issue":"9","key":"1944_CR91","doi-asserted-by":"publisher","first-page":"895","DOI":"10.1177\/1545968309335978","volume":"23","author":"P Stroemer","year":"2009","unstructured":"Stroemer P, Patel S, Hope A, Oliveira C, Pollock K, Sinden J (2009) The neural stem cell line CTX0E03 promotes behavioral recovery and endogenous neurogenesis after experimental stroke in a dose-dependent fashion. Neurorehabil Neural Repair 23(9):895\u2013909. https:\/\/doi.org\/10.1177\/1545968309335978","journal-title":"Neurorehabil Neural Repair"},{"key":"1944_CR93","doi-asserted-by":"publisher","first-page":"6718","DOI":"10.3390\/ijms21186718","volume":"21","author":"S Suda","year":"2020","unstructured":"Suda S, Nito C, Yokobori S, Sakamoto Y, Nakajima M, Sowa K et al (2020) Recent advances in cell-based therapies for ischemic stroke. Int J Mol Sci 21:6718. https:\/\/doi.org\/10.3390\/ijms21186718","journal-title":"Int J Mol Sci"},{"issue":"272","key":"1944_CR94","doi-asserted-by":"publisher","first-page":"78","DOI":"10.1016\/j.expneurol.2015.03.011","volume":"1","author":"J Sun","year":"2015","unstructured":"Sun J, Wei ZZ, Gu X, Zhang JY, Zhang Y, Li J, Wei L (2015) Intranasal delivery of hypoxia-preconditioned bone marrow-derived mesenchymal stem cells enhanced regenerative effects after intracerebral hemorrhagic stroke in mice. Exp Neurol 1(272):78\u201387","journal-title":"Exp Neurol"},{"key":"1944_CR95","doi-asserted-by":"publisher","first-page":"663","DOI":"10.1016\/j.cell.2006.07.024","volume":"126","author":"K Takahashi","year":"2006","unstructured":"Takahashi K, Yamanaka SJC (2006) Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Cell 126:663\u2013676. https:\/\/doi.org\/10.1016\/j.cell.2006.07.024","journal-title":"Cell"},{"issue":"3","key":"1944_CR119","first-page":"692","volume":"140","author":"D Tornero","year":"2017","unstructured":"Tornero D, Tsupykov O, Granmo M, Rodriguez C, Gr\u00f8nning-Hansen M, Thelin J, Smozhanik E, Laterza C, Wattananit S, Ge R, Tatarishvili J (2017) Synaptic inputs from stroke-injured brain to grafted human stem cell-derived neurons activated by sensory stimuli. Brain  140(3):692\u2013706","journal-title":"Brain"},{"issue":"2","key":"1944_CR98","doi-asserted-by":"publisher","first-page":"194","DOI":"10.1016\/0014-4886(95)90025-X","volume":"132","author":"K Uchida","year":"1995","unstructured":"Uchida K, Kawaja MD, Toya S, Roach AH (1995) Transgenic neural plate contributes neuronal cells that survive greater than one year when transplanted into the adult mouse central nervous system. Exp Neurol 132(2):194\u2013208. https:\/\/doi.org\/10.1016\/0014-4886(95)90025-X","journal-title":"Exp Neurol"},{"key":"1944_CR99","doi-asserted-by":"publisher","first-page":"428","DOI":"10.1161\/strokeaha.116.014950","volume":"48","author":"H Uchida","year":"2017","unstructured":"Uchida H, Niizuma K, Kushida Y, Wakao S, Tominaga T, Borlongan CV et al (2017) Human muse cells reconstruct neuronal circuitry in subacute lacunar stroke model. Stroke 48:428\u2013435. https:\/\/doi.org\/10.1161\/strokeaha.116.014950","journal-title":"Stroke"},{"issue":"10","key":"1944_CR101","doi-asserted-by":"publisher","first-page":"2390","DOI":"10.1161\/01.STR.0000141681.06735.9b","volume":"35","author":"M Vendrame","year":"2004","unstructured":"Vendrame M, Cassady J, Newcomb J, Butler T, Pennypacker KR, Zigova T, Sanberg CD, Sanberg PR, Willing AE (2004) Infusion of human umbilical cord blood cells in a rat model of stroke dose-dependently rescues behavioral deficits and reduces infarct volume. Stroke 35(10):2390\u20132395. https:\/\/doi.org\/10.1161\/01.STR.0000141681.06735.9b","journal-title":"Stroke"},{"key":"1944_CR102","doi-asserted-by":"publisher","first-page":"372","DOI":"10.1038\/pr.2017.243","volume":"83","author":"N Wagenaar","year":"2018","unstructured":"Wagenaar N, de Theije CGM, de Vries LS, Groenendaal F, Benders M, Nijboer CHA (2018) Promoting neuroregeneration after perinatal arterial ischemic stroke: neurotrophic factors and mesenchymal stem cells. Pediatr Res 83:372\u2013384. https:\/\/doi.org\/10.1038\/pr.2017.243","journal-title":"Pediatr Res"},{"key":"1944_CR103","doi-asserted-by":"publisher","first-page":"1017","DOI":"10.1002\/jnr.22279","volume":"88","author":"K Wakabayashi","year":"2010","unstructured":"Wakabayashi K, Nagai A, Sheikh AM, Shiota Y, Narantuya D, Watanabe T et al (2010a) Transplantation of human mesenchymal stem cells promotes functional improvement and increased expression of neurotrophic factors in a rat focal cerebral ischemia model. J Neurosci Res 88:1017\u20131025. https:\/\/doi.org\/10.1002\/jnr.22279","journal-title":"J Neurosci Res"},{"key":"1944_CR104","doi-asserted-by":"publisher","first-page":"9875","DOI":"10.1073\/pnas.1100816108","volume":"108","author":"S Wakao","year":"2011","unstructured":"Wakao S, Kitada M, Kuroda Y, Shigemoto T, Matsuse D, Akashi H et al (2011) Multilineage-differentiating stress-enduring (Muse) cells are a primary source of induced pluripotent stem cells in human fibroblasts. Proc Natl Acad Sci USA 108:9875\u20139880. https:\/\/doi.org\/10.1073\/pnas.1100816108","journal-title":"Proc Natl Acad Sci USA"},{"key":"1944_CR105","doi-asserted-by":"publisher","first-page":"1569","DOI":"10.1161\/STROKEAHA.107.502047","volume":"39","author":"P Walczak","year":"2008","unstructured":"Walczak P, Zhang J, Gilad AA et al (2008) Dual-modality monitoring of targeted intraarterial delivery of mesenchymal stem cells after transient ischemia. Stroke 39:1569\u20131574","journal-title":"Stroke"},{"key":"1944_CR106","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-7091-1175-8_2","author":"AE Willing","year":"2013","unstructured":"Willing AE, Shahaduzzaman M (2013) Delivery routes for cell therapy in stroke. Cell-Based Therap Stroke. https:\/\/doi.org\/10.1007\/978-3-7091-1175-8_2","journal-title":"Cell-Based Therap Stroke"},{"issue":"(1-2)","key":"1944_CR120","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1016\/j.brainresbull.2005.08.016","volume":"68","author":"S Wislet-Gendebien","year":"2005","unstructured":"Wislet-Gendebien S, Wautier F, Leprince P, Rogister B (2005) Astrocytic and neuronal fate of mesenchymal stem cells expressing nestin. Brain research bulletin. 15;68(1-2):95\u2013102","journal-title":"rain research bulletin"},{"issue":"6","key":"1944_CR124","doi-asserted-by":"publisher","first-page":"722","DOI":"10.1089\/scd.2005.14.722","volume":"14","author":"J Xiao","year":"2005","unstructured":"Xiao J, Nan Z, Motooka Y, Low WC (2005) Transplantation of a novel cell line population of umbilical cord blood stem cells ameliorates neurological deficits associated with ischemic brain injury. Stem cells and development 14(6):722\u201333","journal-title":"Stem cells and development"},{"key":"1944_CR108","doi-asserted-by":"publisher","first-page":"391","DOI":"10.3727\/096368909788809767","volume":"18","author":"T Yang","year":"2009","unstructured":"Yang T, Tsang KS, Poon WS, Ng HK (2009) Neurotrophism of bone marrow stromal cells to embryonic stem cells: noncontact induction and transplantation to a mouse ischemic stroke model. Cell Transplant 18:391\u2013404. https:\/\/doi.org\/10.3727\/096368909788809767","journal-title":"Cell Transplant"},{"issue":"5","key":"1944_CR109","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0093735","volume":"9","author":"DR Yavagal","year":"2014","unstructured":"Yavagal DR, Lin B, Raval AP, Garza PS, Dong C, Zhao W, Rangel EB, McNiece I, Rundek T, Sacco RL, Perez-Pinzon M (2014) Efficacy and dose-dependent safety of intra-arterial delivery of mesenchymal stem cells in a rodent stroke model. PLoS ONE 9(5):e93735","journal-title":"PLoS ONE"},{"key":"1944_CR111","doi-asserted-by":"publisher","first-page":"104","DOI":"10.1016\/j.brainres.2012.10.017","volume":"1489","author":"zangL Zhang","year":"2012","unstructured":"Zhang zangL, Li Y, Romanko M et al (2012) Different routes of administration of human umbilical tissue-derived cells improve functional recovery in the rat after focal cerebral ischemia. Brain Res 1489:104\u2013112","journal-title":"Brain Res"},{"issue":"3","key":"1944_CR112","doi-asserted-by":"publisher","first-page":"210","DOI":"10.1161\/CIRCULATIONAHA.120.049497","volume":"144","author":"M Zhao","year":"2021","unstructured":"Zhao M, Nakada Y, Wei Y, Bian W, Chu Y, Borovjagin AV, Xie M, Zhu W, Nguyen T, Zhou Y, Serpooshan V (2021) Cyclin D2 overexpression enhances the efficacy of human induced pluripotent stem cell\u2013derived cardiomyocytes for myocardial repair in a swine model of myocardial infarction. Circulation 144(3):210\u2013228","journal-title":"Circulation"},{"key":"1944_CR114","doi-asserted-by":"publisher","first-page":"636","DOI":"10.1177\/1545968310361958","volume":"24","author":"J Zhong","year":"2010","unstructured":"Zhong J, Chan A, Morad L, Kornblum HI, Fan G, Carmichael ST (2010) Hydrogel matrix to support stem cell survival after brain transplantation in stroke. Neurorehabil Neural Repair 24:636\u2013644","journal-title":"Neurorehabil Neural Repair"}],"container-title":["Inflammopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10787-025-01944-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10787-025-01944-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10787-025-01944-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,18]],"date-time":"2025-12-18T11:03:59Z","timestamp":1766055839000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10787-025-01944-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,8]]},"references-count":100,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2025,12]]}},"alternative-id":["1944"],"URL":"https:\/\/doi.org\/10.1007\/s10787-025-01944-2","relation":{},"ISSN":["0925-4692","1568-5608"],"issn-type":[{"value":"0925-4692","type":"print"},{"value":"1568-5608","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11,8]]},"assertion":[{"value":"7 July 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"31 August 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 November 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors have no relevant financial or non-financial interests to disclose.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"Not applicable.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}},{"value":"All authors read and gave their consent for the final manuscript.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}}]}}