{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T15:40:24Z","timestamp":1786981224487,"version":"build-2736575974"},"reference-count":87,"publisher":"Springer Science and Business Media LLC","issue":"10","license":[{"start":{"date-parts":[[2025,9,26]],"date-time":"2025-09-26T00:00:00Z","timestamp":1758844800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,9,26]],"date-time":"2025-09-26T00:00:00Z","timestamp":1758844800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100006162","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Ci\u00eancia e Tecnologia do Estado de Pernambuco","doi-asserted-by":"publisher","award":["BFP-0038-2.08\/23"],"award-info":[{"award-number":["BFP-0038-2.08\/23"]}],"id":[{"id":"10.13039\/501100006162","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004809","name":"Financiadora de Estudos e Projetos","doi-asserted-by":"publisher","award":["01.23.0505.00 - REF. 2636\/22"],"award-info":[{"award-number":["01.23.0505.00 - REF. 2636\/22"]}],"id":[{"id":"10.13039\/501100004809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Inflammopharmacol"],"published-print":{"date-parts":[[2025,10]]},"DOI":"10.1007\/s10787-025-01972-y","type":"journal-article","created":{"date-parts":[[2025,9,26]],"date-time":"2025-09-26T07:40:46Z","timestamp":1758872446000},"page":"6273-6285","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["In vitro antioxidant activity and in vivo antinociceptive and anti-inflammatory effects of the hydroethanolic extract from leaves of Myrciaria floribunda (H. West ex Willd.) O. Berg in Swiss mice"],"prefix":"10.1007","volume":"33","author":[{"given":"Izabelly Bianca","family":"da Silva Santos","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simone Patricia","family":"de Freitas Rosa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wendel C\u00e9sar eSilva","family":"Pereira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruno Souza","family":"dos Santos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natanael Teles Ramos","family":"de Lima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 Maria Barbosa","family":"Filho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alisson Mac\u00e1rio","family":"de Oliveira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thiago Henrique","family":"Napole\u00e3o","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Tereza","family":"dos Santos Correia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7925-6794","authenticated-orcid":false,"given":"W\u00eandeo Kennedy","family":"Costa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcia Vanusa","family":"da Silva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,9,26]]},"reference":[{"issue":"14","key":"1972_CR1","doi-asserted-by":"crossref","DOI":"10.3390\/molecules26144338","volume":"26","author":"S Affes","year":"2021","unstructured":"Affes S et al (2021) ESI-MS\/MS analysis of phenolic compounds from Aeonium arboreum leaf extracts and evaluation of their antioxidant and antimicrobial activities. Molecules 26(14):4338","journal-title":"Molecules"},{"issue":"18","key":"1972_CR3","doi-asserted-by":"publisher","first-page":"10719","DOI":"10.3390\/ijms231810719","volume":"23","author":"S Alfaro","year":"2022","unstructured":"Alfaro S, Acu\u00f1a V, Ceriani R, Cavieres MF, Weinstein-Oppenheimer CR, Campos-Estrada C (2022) Involvement of inflammation and its resolution in disease and therapeutics. Int J Mol Sci 23(18):10719. https:\/\/doi.org\/10.3390\/ijms231810719","journal-title":"Int J Mol Sci"},{"issue":"3","key":"1972_CR4","first-page":"284","volume":"38","author":"AA Anekar","year":"2023","unstructured":"Anekar AA, Cascella M (2023) WHO Analgesic Ladder. J Royal College Phys Edinburgh 38(3):284","journal-title":"J Royal College Phys Edinburgh"},{"key":"1972_CR6","doi-asserted-by":"crossref","first-page":"104","DOI":"10.3177\/jnsv.57.104","volume":"7","author":"KY Azawa","year":"2011","unstructured":"Azawa KY et al (2011) Anti-Inflammatory effects of seeds of the tropical fruit camu-camu ( Myrciaria dubia ). J Nutr Sci Vitaminol 7:104\u2013107","journal-title":"J Nutr Sci Vitaminol"},{"key":"1972_CR7","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1016\/j.jep.2016.07.001","volume":"192","author":"LF Azevedo","year":"2016","unstructured":"Azevedo LF et al (2016) Evidence of anti-inflammatory and antinociceptive activities of Plinia edulis leaf infusion. J Ethnopharmacol 192:178\u2013182","journal-title":"J Ethnopharmacol"},{"key":"1972_CR8","first-page":"1","volume":"6419","author":"MM Azevedo","year":"2017","unstructured":"Azevedo MM, De L et al (2017) Lupane triterpenoids, antioxidant potential and antimicrobial activity of Myrciaria floribunda (H. West ex Willd.) O. Berg. Nat Product Res 6419:1\u201310","journal-title":"Nat Product Res"},{"key":"1972_CR10","doi-asserted-by":"publisher","DOI":"10.1080\/02648725.2022.2122303","author":"T Benali","year":"2022","unstructured":"Benali T et al (2022) Pharmacological insights into the multifaceted biological properties of quinic acid. Biotechnol Genet Eng Rev. https:\/\/doi.org\/10.1080\/02648725.2022.2122303","journal-title":"Biotechnol Genet Eng Rev"},{"issue":"7","key":"1972_CR11","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3390\/antiox8070205","volume":"8","author":"N Bouaoudia-MadI","year":"2019","unstructured":"Bouaoudia-MadI N et al (2019) Optimization of ultrasound-assisted extraction of polyphenols from myrtus communis L. Pericarp. Antioxidants 8(7):1\u201317","journal-title":"Antioxidants"},{"issue":"1","key":"1972_CR12","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1016\/S0023-6438(95)80008-5","volume":"28","author":"W Brand-Williams","year":"1995","unstructured":"Brand-Williams W, Cuvelier ME, Berset C (1995) Use of a free radical method to evaluate antioxidant activity. LWT Food Sci Technol 28(1):25\u201330. https:\/\/doi.org\/10.1016\/S0023-6438(95)80008-5","journal-title":"LWT Food Sci Technol"},{"key":"1972_CR13","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.jep.2020.113611","volume":"268","author":"TG Brito","year":"2021","unstructured":"Brito TG, S DA et al (2021) Anti-inflammatory, hypoglycemic, hypolipidemic, and analgesic activities of Plinia cauliflora (Mart) Kausel (Brazilian grape) epicarp. J Ethnopharmacol 268:25","journal-title":"J Ethnopharmacol"},{"key":"1972_CR14","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.foodchem.2016.06.042","volume":"213","author":"O Bujor","year":"2016","unstructured":"Bujor O et al (2016) Seasonal variations of the phenolic constituents in bilberry (Vaccinium myrtillus L.) leaves, stems and fruits, and their antioxidant activity. Food Chem 213:58\u201368","journal-title":"Food Chem"},{"key":"1972_CR15","doi-asserted-by":"crossref","unstructured":"Candeia, GL., O. De M. et al (2022) Anti-inflammatory, antinociceptive effects and involvement of opioid receptors in the antinociceptive activity of Eugenia uniflora leaves obtained with water, ethanol, and propylene glycol mixture. J Ethnopharmacol 296","DOI":"10.1016\/j.jep.2022.115508"},{"key":"1972_CR16","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/j.jff.2011.03.007","volume":"3","author":"A Chandrasekara","year":"2011","unstructured":"Chandrasekara A, Fereidoon S (2011) Determination of antioxidant activity in free and hydrolyzed fractions of millet grains and characterization of their phenolic profiles by HPLC-DAD-ESI-MSn. J Funct Foods 3:144\u201358","journal-title":"J Funct Foods"},{"issue":"29","key":"1972_CR17","doi-asserted-by":"crossref","first-page":"7102","DOI":"10.1021\/jf4020284","volume":"61","author":"WC Chang","year":"2013","unstructured":"Chang WC, Shen SC, Wubb JS (2013) Protective effects of vescalagin from Pink wax apple [Syzygium samarangense (Blume) Merrill and Perry] fruit against methylglyoxal-induced inflammation and carbohydrate metabolic disorder in rats. J Agricult Food Chem 61(29):7102\u20137109","journal-title":"J Agricult Food Chem"},{"key":"1972_CR18","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/8623909","author":"Z Chang","year":"2019","unstructured":"Chang Z et al (2019) A comprehensive review of the structure elucidation of tannins from Terminalia Linn. Evid-Based Complement Alternat Med. https:\/\/doi.org\/10.1155\/2019\/8623909","journal-title":"Evid-Based Complement Alternat Med"},{"key":"1972_CR19","doi-asserted-by":"publisher","DOI":"10.1002\/cbdv.202200217","author":"R Chawech","year":"2022","unstructured":"Chawech R et al (2022) \u201cPolyphenol Characterization of the Aqueous Extract from Hubertia Ambavilla L. (Asteraceae) by HPLC-DAD-ESI-MSn and Assessment of Its Antioxidant Activity.\u201d Chem Biodivers. https:\/\/doi.org\/10.1002\/cbdv.202200217","journal-title":"Chem Biodivers"},{"issue":"2","key":"1972_CR20","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1007\/s10787-022-00940-0","volume":"30","author":"WK Costa","year":"2022","unstructured":"Costa WK et al (2022) Oral administration of essential oil from Psidium glaziovianum Kiaersk leaves alleviates pain and inflammation in mice. Inflammopharmacol 30(2):599\u2013607","journal-title":"Inflammopharmacol"},{"issue":"1","key":"1972_CR21","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1590\/S0102-695X2009000200006","volume":"19","author":"AN Daniel","year":"2009","unstructured":"Daniel AN et al (2009) Anti-inflammatory and antinociceptive activities of eugenol essential oil in experimental animal models. Brazilian J Pharmacognosy 19(1):212\u2013217","journal-title":"Brazilian J Pharmacognosy"},{"key":"1972_CR22","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/406960","author":"QN Dinh","year":"2014","unstructured":"Dinh QN et al (2014) Roles of inflammation, oxidative stress, and vascular dysfunction in hypertension. BioMed Res Int. https:\/\/doi.org\/10.1155\/2014\/406960","journal-title":"BioMed Res Int"},{"key":"1972_CR23","doi-asserted-by":"crossref","unstructured":"Fathoni, A. et al. 2017 Identification of nonvolatile compounds in clove (Syzygium aromaticum) from Manado. In: AIP Conference Proceedings. AIP Publishing,.","DOI":"10.1063\/1.4991183"},{"key":"1972_CR24","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.jep.2012.10.037","volume":"145","author":"LC Ferreira","year":"2013","unstructured":"Ferreira LC et al (2013) Anti-inflammatory and antinociceptive activities of Campomanesia adamantium. J Ethnopharmacol 145:100\u2013108","journal-title":"J Ethnopharmacol"},{"issue":"2","key":"1972_CR26","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1016\/j.foodchem.2010.12.156","volume":"127","author":"UA Fischer","year":"2011","unstructured":"Fischer UA, Carle R, Kammerer DR (2011) Identification and quantification of phenolic compounds from pomegranate (Punica granatum L.) peel, mesocarp, aril and differently produced juices by HPLC-DAD\u2013ESI\/MSn. Food Chem 127(2):807\u2013821","journal-title":"Food Chem"},{"key":"1972_CR27","doi-asserted-by":"publisher","DOI":"10.3390\/foods10020251","author":"M Fraga-Corral","year":"2021","unstructured":"Fraga-Corral M et al (2021) Traditional applications of tannin rich extracts supported by scientific data: chemical composition, bioavailability and bioaccessibility. Foods. https:\/\/doi.org\/10.3390\/foods10020251"},{"issue":"n. 6","key":"1972_CR28","volume":"10","author":"D Fraternale","year":"2015","unstructured":"Fraternale D et al (2015) Activity of Vitis vinifera tendrils extract against phytopathogenic fungi. Nat Prod Commun 10(n. 6):1934578X1501000661","journal-title":"Nat Prod Commun"},{"key":"1972_CR29","doi-asserted-by":"crossref","unstructured":"FRIAS, B.; MERIGHI, A. Capsaicin, nociception and pain. Molecules, v. 21, n. 6, 2016","DOI":"10.3390\/molecules21060797"},{"key":"1972_CR94","doi-asserted-by":"crossref","unstructured":"Ghasemi-Dehnoo M et al (2023) Quinic acid ameliorates ulcerative colitis in rats, through the inhibition of two TLR4-NF-\u03baB and NF-\u03baB-INOS-NO signaling pathways. Immunity, Inflammation and Disease, 11(8):1 ago. 2023","DOI":"10.1002\/iid3.926"},{"issue":"5","key":"1972_CR30","doi-asserted-by":"crossref","DOI":"10.3390\/metabo11050281","volume":"11","author":"P Gomes","year":"2021","unstructured":"Gomes P et al (2021) Feature-based molecular network-guided dereplication of natural bioactive products from leaves of Stryphnodendron pulcherrimum (Willd.) Hochr. Metabolites 11(5):281","journal-title":"Metabolites"},{"issue":"5","key":"1972_CR31","doi-asserted-by":"crossref","first-page":"398","DOI":"10.3390\/antiox9050398","volume":"9","author":"P Goufo","year":"2020","unstructured":"Goufo P, Singh RK, Cortez I (2020) A reference list of phenolic compounds (including stilbenes) in grapevine (Vitis vinifera L.) roots, woods, canes, stems, and leaves. Antioxidants 9(5):398","journal-title":"Antioxidants"},{"issue":"10","key":"1972_CR32","doi-asserted-by":"crossref","first-page":"992","DOI":"10.1016\/j.ejpain.2010.04.005","volume":"14","author":"T Hagenacker","year":"2010","unstructured":"Hagenacker T et al (2010) Anti-allodynic effect of the flavonoid myricetin in a rat model of neuropathic pain: Involvement of p38 and protein kinase C mediated modulation of Ca2+ channels. Eur J Pain 14(10):992\u2013998","journal-title":"Eur J Pain"},{"issue":"5","key":"1972_CR33","doi-asserted-by":"crossref","first-page":"1485","DOI":"10.1016\/j.fct.2012.01.041","volume":"50","author":"GJ Huang","year":"2012","unstructured":"Huang GJ et al (2012) Anti-inflammatory effects of ethanolic extract of Antrodia salmonea in the lipopolysaccharide-stimulated RAW246.7 macrophages and the \u03bb-carrageenan-induced paw edema model. Food Chem Toxicol 50(5):1485\u20131493","journal-title":"Food Chem Toxicol"},{"issue":"1","key":"1972_CR34","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/0304-3959(87)90088-1","volume":"30","author":"S Hunskaar","year":"1987","unstructured":"Hunskaar S, Hole K (1987) The formalin test in mice: dissociation between inflammatory and non-inflammatory pain. Pain 30(1):103\u2013114","journal-title":"Pain"},{"issue":"6312","key":"1972_CR35","first-page":"572","volume":"354","author":"R Ji","year":"2016","unstructured":"Ji R, Chamessian A, Zhang Y (2016) Pain regulation by non-neuronal cells and inflammation. Pain Res 354(6312):572\u2013577","journal-title":"Pain Res"},{"key":"1972_CR36","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.foodchem.2016.05.052","volume":"211","author":"J Kang","year":"2016","unstructured":"Kang J et al (2016) Identification and characterization of phenolic compounds in hydromethanolic extracts of sorghum wholegrains by LC-ESI-MSn. Food Chem 211:215\u2013226","journal-title":"Food Chem"},{"issue":"2","key":"1972_CR37","doi-asserted-by":"publisher","first-page":"487","DOI":"10.1007\/S40122-020-00200-5\/TABLES\/2","volume":"9","author":"AS Kaushik","year":"2020","unstructured":"Kaushik AS, Strath LJ, Sorge RE (2020) Dietary interventions for treatment of chronic pain: oxidative stress and inflammation. Pain Ther 9(2):487\u2013498. https:\/\/doi.org\/10.1007\/S40122-020-00200-5\/TABLES\/2","journal-title":"Pain Ther"},{"issue":"1","key":"1972_CR38","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12906-015-0558-y","volume":"15","author":"A Khatun","year":"2015","unstructured":"Khatun A, Imam MZ, Rana MS (2015) Antinociceptive effect of methanol extract of leaves of Persicaria hydropiper in mice. BMC Complement Altern Med 15(1):1\u20138","journal-title":"BMC Complement Altern Med"},{"issue":"2","key":"1972_CR39","first-page":"1","volume":"7","author":"AT Khorasgani","year":"2021","unstructured":"Khorasgani AT et al (2021) Quinic acid through mitigation of oxidative stress in the hippocampus exerts analgesic effect in male mice. Adv Herbal Med Summ Autumn 7(2):1\u201311","journal-title":"Adv Herbal Med Summ Autumn"},{"issue":"12","key":"1972_CR40","doi-asserted-by":"crossref","first-page":"1533","DOI":"10.1007\/s12272-013-0147-x","volume":"36","author":"HH Kim","year":"2013","unstructured":"Kim HH et al (2013) Flavonoid constituents in the leaves of Myrica rubra sieb et. zucc with anti-inflammatory activity. Arch Pharmacal Res 36(12):1533\u20131540","journal-title":"Arch Pharmacal Res"},{"issue":"n. 8","key":"1972_CR41","doi-asserted-by":"crossref","DOI":"10.3390\/ph13080191","volume":"13","author":"S Lachowicz","year":"2020","unstructured":"Lachowicz S et al (2020) Profile and content of phenolic compounds in leaves, flowers, roots, and stalks of Sanguisorba officinalis L. determined with the LC-DAD-ESI-QTOF-MS\/MS analysis and their in vitro antioxidant, antidiabetic, antiproliferative potency. Pharmaceuticals 13(n. 8):191","journal-title":"Pharmaceuticals"},{"key":"1972_CR42","first-page":"2008","volume":"144","author":"AJ Lapa","year":"2008","unstructured":"Lapa AJ, Souccar C, Lima-Landman TR, Castro MAS, Lima TCM (2008) Plantas Medicinais: M\u00e9todos de avalia\u00e7\u00e3o da atividade farmacol\u00f3gica. Sociedade Brasileira de Plantas Medicinais, Brasileira","journal-title":"Sociedade Brasileira De Plantas Medicinais"},{"issue":"23","key":"1972_CR43","doi-asserted-by":"crossref","first-page":"9678","DOI":"10.1021\/jf0717945","volume":"55","author":"KM Lee","year":"2007","unstructured":"Lee KM et al (2007) Myricetin down-regulates phorbol ester-induced cyclooxygenase-2 expression in mouse epidermal cells by blocking activation of nuclear factor kappa B. J Agricult Food Chem 55(23):9678\u20139684","journal-title":"J Agricult Food Chem"},{"issue":"12","key":"1972_CR44","first-page":"982","volume":"93","author":"A Lembke","year":"2016","unstructured":"Lembke A, Humphreys K, Newmark J (2016) Weighing the risks and benefits of chronic opioid therapy. Am Fam Phys 93(12):982\u2013990","journal-title":"Am Fam Phys"},{"key":"1972_CR45","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/j.foodres.2015.07.023","volume":"77","author":"SA Lenquiste","year":"2015","unstructured":"Lenquiste SA et al (2015) Jaboticaba peel and jaboticaba peel aqueous extract shows in vitro and in vivo antioxidant properties in obesity model. Food Res Int 77:162\u2013170","journal-title":"Food Res Int"},{"key":"1972_CR47","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.indcrop.2017.05.023","volume":"107","author":"EJ Llorent-Mart\u00ednez","year":"2017","unstructured":"Llorent-Mart\u00ednez EJ, Sp\u00ednola V, Castilho PC (2017) Phenolic profiles of Lauraceae plant species endemic to Laurisilva forest: a chemotaxonomic survey. Ind Crop Prod 107:1\u201312","journal-title":"Ind Crop Prod"},{"key":"1972_CR48","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.pbb.2014.02.009","volume":"120","author":"MT Mansouri","year":"2014","unstructured":"Mansouri MT, Naghizadeh B, Ghorbanzadeh B (2014) Involvement of opioid receptors in the systemic and peripheral antinociceptive actions of ellagic acid in the rat formalin test. Pharmacol Biochem Behav 120:43\u201349","journal-title":"Pharmacol Biochem Behav"},{"issue":"3","key":"1972_CR49","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1007\/s10787-019-00652-y","volume":"28","author":"DJ Marmitt","year":"2020","unstructured":"Marmitt DJ et al (2020) Neuroprotective potential of Myrciaria plinioides D. Legrand extract in an in vitro human neuroblastoma model. Inflammopharmacology 28(3):737\u2013748","journal-title":"Inflammopharmacology"},{"issue":"12","key":"1972_CR50","doi-asserted-by":"crossref","first-page":"14821","DOI":"10.3390\/molecules171214821","volume":"17","author":"P Mena","year":"2012","unstructured":"Mena P et al (2012) Rapid and comprehensive evaluation of (poly) phenolic compounds in pomegranate (Punica granatum L.) juice by UHPLC-MSn. Molecules 17(12):14821\u201314840","journal-title":"Molecules"},{"issue":"3","key":"1972_CR52","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1016\/j.jep.2013.05.040","volume":"148","author":"J Mo","year":"2013","unstructured":"Mo J et al (2013) Topical anti-inflammatory and analgesic activities of standardized pomegranate rind extract in comparison with its marker compound ellagic acid in vivo. J Ethnopharmacol 148(3):901\u2013908","journal-title":"J Ethnopharmacol"},{"key":"1972_CR96","doi-asserted-by":"crossref","unstructured":"Moraes PGS, da Silva Santos IB, Silva VBG, dede Oliveira FariasAguiar JCR, do Amaral Ferraz Navarro DM, de Oliveira AM, da Silva MV (2023) Essential oil from leaves of Myrciaria floribunda (H. West ex Willd.) O. Berg has antinociceptive and anti-inflammatory potential. Inflammopharmacology 31(6):3143\u20133151","DOI":"10.1007\/s10787-023-01300-2"},{"issue":"2","key":"1972_CR53","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1016\/S0031-9422(03)00281-4","volume":"64","author":"W Mullen","year":"2003","unstructured":"Mullen W et al (2003) Analysis of ellagitannins and conjugates of ellagic acid and quercetin in raspberry fruits by LC\u2013MSn. Phytochemistry 64(2):617\u2013624","journal-title":"Phytochemistry"},{"key":"1972_CR54","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.foodchem.2018.01.078","volume":"252","author":"N Neves","year":"2018","unstructured":"Neves N et al (2018) Flavonols and ellagic acid derivatives in peels of different species of jabuticaba (Plinia spp.) identified by HPLC-DAD-ESI\/MSn. Food Chem 252:61\u201371","journal-title":"Food Chem"},{"key":"1972_CR95","doi-asserted-by":"crossref","unstructured":"Oliveira AM, do Nascimento MF, Ferreira MRA, de Moura DF, dos Santos Souza TG, da Silva GC, Napole\u00e3o TH (2016) Evaluation of acute toxicity, genotoxicity and inhibitory effect on acute inflammation of an ethanol extract of Morus alba L.(Moraceae) in mice. J Ethnopharmacol 194:162\u2013168","DOI":"10.1016\/j.jep.2016.09.004"},{"key":"1972_CR55","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/j.yrtph.2018.04.004","volume":"95","author":"AM Oliveira","year":"2018","unstructured":"Oliveira AM et al (2018) Saline extract of Pilosocereus gounellei stem has antinociceptive effect in mice without showing acute toxicity and altering motor coordination. Regul Toxicol Pharmacol 95:289\u2013297","journal-title":"Regul Toxicol Pharmacol"},{"issue":"3","key":"1972_CR56","doi-asserted-by":"crossref","first-page":"326","DOI":"10.3390\/plants11030326","volume":"11","author":"A Patient","year":"2022","unstructured":"Patient A et al (2022) Polyphenol Composition and Antioxidant Activity of Tapirira guianensis Aubl (Anarcadiaceae) Leaves. Plants 11(3):326","journal-title":"Plants"},{"key":"1972_CR57","doi-asserted-by":"crossref","unstructured":"Paula P, De L et al (2021) Pharmacological investigation of antioxidant and anti-inflammatory activities of leaves and branches extracts from Plinia cauliflora (Jaboticaba). J Ethnopharmacol 280:114463","DOI":"10.1016\/j.jep.2021.114463"},{"key":"1972_CR58","first-page":"10507","volume":"4","author":"MTM Pereira","year":"2019","unstructured":"Pereira MTM et al (2019) Myrciaria Glazioviana Leaves Anti-Inflammatory Antinociceptive and Hepatoprotection potential and chemical profile by mass spectrometry. Biomed J Sci Tech Res 4:10507\u201311051","journal-title":"Biomed J Sci Tech Res"},{"key":"1972_CR59","first-page":"12","volume":"19","author":"MTM Pereira","year":"2022","unstructured":"Pereira MTM et al (2022) Myrciaria genus: bioactive compounds and biological activities. Chem Biodiver 19:12","journal-title":"Chem Biodiver"},{"key":"1972_CR60","doi-asserted-by":"crossref","unstructured":"Phadi S et al (2024) Flavonoids as Functional Foods and Nutraceuticals: Recent Advances. Functional Foods and Nutraceuticals: Chemistry, Health Benefits and the Way Forward, 173\u2013198","DOI":"10.1007\/978-3-031-59365-9_8"},{"key":"1972_CR61","unstructured":"Piazza S et al (2021) The effect of tannins from Castanea sativa Mill. on inflammation induced by Helicobacter pylori in gastric epithelial cells. 2021"},{"issue":"4","key":"1972_CR62","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1002\/pca.2415","volume":"24","author":"JP Piwowarski","year":"2013","unstructured":"Piwowarski JP, Kiss AK (2013) C-glucosidic ellagitannins from Lythri herba (European Pharmacopoeia): chromatographic profile and structure determination. Phytochem Anal 24(4):336\u2013348","journal-title":"Phytochem Anal"},{"key":"1972_CR63","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1006\/abio.1999.4019","volume":"341","author":"P Prieto","year":"1999","unstructured":"Prieto P, Pineda M, Aguilar M (1999) Spectrophotometric quantitation of antioxidant capacity through the formation of a phosphomolybdenum complex: specific application to the determination of vitamin E. Anal Biochem 341:337\u2013341","journal-title":"Anal Biochem"},{"issue":"2","key":"1972_CR64","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1016\/j.jep.2010.01.041","volume":"128","author":"AC Queiroz","year":"2010","unstructured":"Queiroz AC et al (2010) The antinociceptive and anti-inflammatory activities of Piptadenia stipulacea Benth (Fabaceae). J Ethnopharmacol 128(2):377\u2013383","journal-title":"J Ethnopharmacol"},{"issue":"12","key":"1972_CR65","volume":"8","author":"PAB Ramos","year":"2019","unstructured":"Ramos PAB et al (2019) The health-promoting potential of Salix spp. bark polar extracts: key insights on phenolic composition and in vitro bioactivity and biocompatibility. Antioxidants 8(12):609","journal-title":"Antioxidants"},{"key":"1972_CR67","doi-asserted-by":"publisher","DOI":"10.1016\/J.BIOPHA.2022.112958","volume":"150","author":"H Ribeiro","year":"2022","unstructured":"Ribeiro H et al (2022) Non-steroidal anti-inflammatory drugs (NSAIDs), pain and aging: adjusting prescription to patient features. Biomed Pharmacother 150:112958. https:\/\/doi.org\/10.1016\/J.BIOPHA.2022.112958","journal-title":"Biomed Pharmacother"},{"key":"1972_CR68","doi-asserted-by":"crossref","first-page":"5445291","DOI":"10.1155\/2022\/5445291","volume":"1","author":"A Roy","year":"2022","unstructured":"Roy A et al (2022) Flavonoids a bioactive compound from medicinal plants and its therapeutic applications. BioMed Res Int 1:5445291","journal-title":"BioMed Res Int"},{"issue":"3","key":"1972_CR69","doi-asserted-by":"crossref","first-page":"512","DOI":"10.3390\/ijms18030512","volume":"18","author":"R Said","year":"2017","unstructured":"Said R et al (2017) Tentative characterization of polyphenolic compounds in the male flowers of Phoenix dactylifera by liquid chromatography coupled with mass spectrometry and DFT. Int J Mol Sci 18(3):512","journal-title":"Int J Mol Sci"},{"issue":"14","key":"1972_CR70","doi-asserted-by":"crossref","DOI":"10.3390\/molecules27144399","volume":"27","author":"S Samet","year":"2022","unstructured":"Samet S et al (2022) Antioxidant and antimicrobial activities of Erodium arborescens aerial part extracts and characterization by LC-HESI-MS2 of its acetone extract. Molecules 27(14):4399","journal-title":"Molecules"},{"issue":"5","key":"1972_CR71","doi-asserted-by":"crossref","first-page":"986","DOI":"10.3390\/molecules23050986","volume":"23","author":"C Santos","year":"2018","unstructured":"Santos C et al (2018) Antioxidative, antiproliferative and antimicrobial activities of phenolic compounds from three Myrcia species. Molecules 23(5):986","journal-title":"Molecules"},{"key":"1972_CR72","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2020\/1258707","volume":"2020","author":"IBDAS Santos","year":"2020","unstructured":"Santos IBDAS et al (2020) Antioxidant action and in vivo anti-inflammatory and antinociceptive activities of Myrciaria floribunda fruit peels: possible involvement of opioidergic system. Adv Pharmacol Pharm Sci 2020:1\u201311","journal-title":"Adv Pharmacol Pharm Sci"},{"key":"1972_CR73","first-page":"830","volume":"30","author":"F Silva","year":"2019","unstructured":"Silva F et al (2019) Integrative analysis based on HPLC-DAD-MS\/MS and NMR of Bertholletia excelsa bark biomass residues: determination of ellagic acid derivatives. J Brazilian Chem Soc 30:830\u2013836","journal-title":"J Brazilian Chem Soc"},{"issue":"3","key":"1972_CR74","doi-asserted-by":"crossref","first-page":"121","DOI":"10.4103\/aam.aam_56_18","volume":"18","author":"N Singh","year":"2019","unstructured":"Singh N et al (2019) Inflammation and Cancer. Annal Afr Med 18(3):121","journal-title":"Annal Afr Med"},{"issue":"3","key":"1972_CR75","doi-asserted-by":"crossref","first-page":"144","DOI":"10.5344\/ajev.1965.16.3.144","volume":"16","author":"VL Singleton","year":"1965","unstructured":"Singleton VL, Rossi JAJ (1965) Colorimetry of total phenolics with phosphomolybdic-phosphotungstic acid reagents. Am J Enol Vitic 16(3):144\u2013158","journal-title":"Am J Enol Vitic"},{"issue":"1","key":"1972_CR77","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1080\/19476337.2022.2136761","volume":"20","author":"Y Sun","year":"2022","unstructured":"Sun Y et al (2022) Profiling of volatile and non-volatile compounds in Dianhong by a combined approach of static headspace GC-MS and UPLC-MS. CyTA-Journal of Food 20(1):305\u2013315","journal-title":"CyTA-Journal of Food"},{"issue":"n. 2","key":"1972_CR79","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1590\/0001-3765201720160461","volume":"89","author":"LAC Tietbohl","year":"2017","unstructured":"Tietbohl LAC et al (2017) Antiproliferative activity in tumor cell lines, antioxidant capacity and total phenolic, flavonoid and tannin contents of Myrciaria floribunda. An Acad Bras Cienc 89(n. 2):1111\u20131120","journal-title":"An Acad Bras Cienc"},{"issue":"1","key":"1972_CR80","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/0304-3959(92)90003-T","volume":"51","author":"A Tj\u00f8lsen","year":"1992","unstructured":"Tj\u00f8lsen A et al (1992) The formalin test: an evaluation of the method. Pain 51(1):5\u201317","journal-title":"Pain"},{"issue":"4","key":"1972_CR81","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1007\/s12272-009-1408-6","volume":"32","author":"Y Tong","year":"2009","unstructured":"Tong Y et al (2009) Analgesic activity of myricetin isolated from Myrica rubra Sieb. et Zucc leaves. Arch Pharm Res 32(4):527\u2013533","journal-title":"Arch Pharm Res"},{"key":"1972_CR82","first-page":"1","volume":"8","author":"Z Tong","year":"2022","unstructured":"Tong Z et al (2022) Biological function of plant tannin and its application in animal health. Front Veter Sci 8:1\u20137","journal-title":"Front Veter Sci"},{"issue":"December","key":"1972_CR83","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3389\/fimmu.2019.03009","volume":"10","author":"AG Vanderwall","year":"2019","unstructured":"Vanderwall AG, Milligan ED (2019) Cytokines in pain: harnessing endogenous anti-inflammatory signaling for improved pain management. Front Immunol 10(December):1\u201315. https:\/\/doi.org\/10.3389\/fimmu.2019.03009","journal-title":"Front Immunol"},{"issue":"1","key":"1972_CR84","first-page":"93","volume":"7","author":"V Ventafridda","year":"1985","unstructured":"Ventafridda V et al (1985) WHO guidelines for the use of analgesics in cancer pain. Int J Tissue React 7(1):93\u201396","journal-title":"Int J Tissue React"},{"key":"1972_CR85","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.exppara.2016.12.006","volume":"173","author":"P Vieira","year":"2017","unstructured":"Vieira P et al (2017) The Caatinga endemic Manilkara rufula possesses remarkable activity against Trichomonas vaginalis and Tritrichomonas foetus. Exp Parasitol 173:18\u201328","journal-title":"Exp Parasitol"},{"key":"1972_CR86","volume":"415","author":"X Wang","year":"2023","unstructured":"Wang X et al (2023) Analysis of proanthocyanidins and flavonols in the seedpods of Chinese Antique Lotus: a rich source of antioxidants. Food Chem 415:135756","journal-title":"Food Chem"},{"key":"1972_CR87","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.pbi.2020.04.004","volume":"55","author":"W Wen","year":"2020","unstructured":"Wen W, Alseekh S, Fernie AR (2020) Conservation and diversification of flavonoid metabolism in the plant kingdom. Curr Opin Plant Biol 55:100\u2013108","journal-title":"Curr Opin Plant Biol"},{"issue":"3","key":"1972_CR88","doi-asserted-by":"crossref","first-page":"544","DOI":"10.3181\/00379727-111-27849","volume":"111","author":"CA Winter","year":"1962","unstructured":"Winter CA, Risley EA, Nuss GW (1962) Carrageenin-induced edema in hind paw of the rat as an assay for antiinflammatory drugs. Exp Biol Med 111(3):544\u2013547","journal-title":"Exp Biol Med"},{"issue":"2","key":"1972_CR89","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1080\/00218839.1998.11100961","volume":"37","author":"RG Woisky","year":"1998","unstructured":"Woisky RG, Salatino A (1998) Analysis of propolis: some parameters and procedures for chemical quality control. J Apic Res 37(2):99\u2013105","journal-title":"J Apic Res"},{"issue":"S1","key":"1972_CR90","first-page":"18","volume":"26","author":"K Wojcikowski","year":"2020","unstructured":"Wojcikowski K, Vigar V, Oliver C (2020) New concepts of chronic pain and the potential role of complementary therapies. Altern Ther Health Med 26(S1):18\u201331","journal-title":"Altern Ther Health Med"},{"issue":"2","key":"1972_CR91","first-page":"1","volume":"22","author":"YS Yi","year":"2021","unstructured":"Yi YS (2021) Flavonoids: nutraceuticals for rheumatic diseases via targeting of inflammasome activation. Int J Mol Sci 22(2):1\u201318","journal-title":"Int J Mol Sci"},{"issue":"3","key":"1972_CR92","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1093\/chromsci\/bms138","volume":"51","author":"H Zhao","year":"2013","unstructured":"Zhao H et al (2013) Chemical profiling of the Chinese herb formula Xiao-Cheng-Qi decoction using liquid chromatography coupled with electrospray ionization mass spectrometry. J Chromatogr Sci 51(3):273\u2013285","journal-title":"J Chromatogr Sci"},{"issue":"5","key":"1972_CR93","doi-asserted-by":"crossref","first-page":"1513","DOI":"10.1021\/acs.jafc.8b05814","volume":"67","author":"DK Zhao","year":"2019","unstructured":"Zhao DK et al (2019) Jaboticabin and related polyphenols from jaboticaba (Myrciaria cauliflora) with anti-inflammatory activity for chronic obstructive pulmonary disease. J Agric Food Chem 67(5):1513\u20131520","journal-title":"J Agric Food Chem"}],"container-title":["Inflammopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10787-025-01972-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10787-025-01972-y\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10787-025-01972-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,24]],"date-time":"2025-10-24T19:05:17Z","timestamp":1761332717000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10787-025-01972-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9,26]]},"references-count":87,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2025,10]]}},"alternative-id":["1972"],"URL":"https:\/\/doi.org\/10.1007\/s10787-025-01972-y","relation":{"references":[{"id-type":"doi","id":"10.3390\/foods10020251","asserted-by":"subject"}]},"ISSN":["0925-4692","1568-5608"],"issn-type":[{"value":"0925-4692","type":"print"},{"value":"1568-5608","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,9,26]]},"assertion":[{"value":"7 May 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 September 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 September 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors have not disclosed any competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"conflict of interest"}}]}}