{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T19:10:05Z","timestamp":1792523405837,"version":"4.5.0"},"reference-count":203,"publisher":"Springer Science and Business Media LLC","issue":"11","license":[{"start":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T00:00:00Z","timestamp":1760140800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T00:00:00Z","timestamp":1760140800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Inflammopharmacol"],"published-print":{"date-parts":[[2025,11]]},"DOI":"10.1007\/s10787-025-01985-7","type":"journal-article","created":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T05:37:21Z","timestamp":1760161041000},"page":"6419-6455","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Nrf2 signaling in bone health: unlocking new avenues for osteoporosis management"],"prefix":"10.1007","volume":"33","author":[{"given":"Mitali P.","family":"Lavhale","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satish K.","family":"Mandlik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vaibhav M.","family":"Shinde","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8505-7038","authenticated-orcid":false,"given":"Deepa S.","family":"Mandlik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,10,11]]},"reference":[{"key":"1985_CR2","doi-asserted-by":"publisher","first-page":"3576","DOI":"10.3390\/ijms20143576","volume":"20","author":"TS Agidigbi","year":"2019","unstructured":"Agidigbi TS, Kim C (2019) Reactive oxygen species in osteoclast differentiation and possible pharmaceutical targets of ROS-mediated osteoclast diseases. Int J Mol Sci 20:3576. https:\/\/doi.org\/10.3390\/ijms20143576","journal-title":"Int J Mol Sci"},{"key":"1985_CR3","doi-asserted-by":"publisher","first-page":"35764","DOI":"10.1074\/jbc.M607160200","volume":"281","author":"R Ahmad","year":"2006","unstructured":"Ahmad R, Raina D, Meyer C, Kharbanda S, Kufe D (2006) Triterpenoid CDDO-Me blocks the NF-\u03baB pathway by direct inhibition of IKK\u03b2 on Cys-179. J Biol Chem 281:35764\u201335769. https:\/\/doi.org\/10.1074\/jbc.M607160200","journal-title":"J Biol Chem"},{"key":"1985_CR4","doi-asserted-by":"publisher","first-page":"340","DOI":"10.1138\/20100467","volume":"7","author":"M Almeida","year":"2010","unstructured":"Almeida M (2010) Aging and oxidative stress: a new look at old bone. IBMS BoneKey 7:340\u2013352. https:\/\/doi.org\/10.1138\/20100467","journal-title":"IBMS BoneKey"},{"key":"1985_CR5","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1152\/physrev.00033.2015","volume":"97","author":"M Almeida","year":"2017","unstructured":"Almeida M, Laurent MR, Dubois V, Claessens F, O\u2019Brien CA, Bouillon R, Vanderschueren D, Manolagas SC (2017) Estrogens and androgens in skeletal physiology and pathophysiology. Physiol Rev 97:135\u2013187. https:\/\/doi.org\/10.1152\/physrev.00033.2015","journal-title":"Physiol Rev"},{"key":"1985_CR6","doi-asserted-by":"publisher","first-page":"989","DOI":"10.1042\/CS20150436","volume":"129","author":"O Al-Sawaf","year":"2015","unstructured":"Al-Sawaf O, Clarner T, Fragoulis A, Kan YW, Pufe T, Streetz K, Wruck CJ (2015) Nrf2 in health and disease: current and future clinical implications. Clin Sci 129:989\u2013999. https:\/\/doi.org\/10.1042\/CS20150436","journal-title":"Clin Sci"},{"issue":"6","key":"1985_CR7","doi-asserted-by":"publisher","first-page":"807","DOI":"10.1021\/mp700113r","volume":"4","author":"P Anand","year":"2007","unstructured":"Anand P, Kunnumakkara AB, Newman RA, Aggarwal BB (2007) Bioavailability of curcumin: problems and promises. Mol Pharm 4(6):807\u2013818","journal-title":"Mol Pharm"},{"key":"1985_CR8","volume":"11","author":"R Arora","year":"2012","unstructured":"Arora R, Sawney S, Saini V, Steffi C, Tiwari M, Saluja D, Ralhan R (2012) Honokiol: a novel phytochemical targeting cancer stem cells. Mol Cancer 11:41","journal-title":"Mol Cancer"},{"key":"1985_CR9","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/5276130","volume":"2016","author":"P Arulselvan","year":"2016","unstructured":"Arulselvan P, Tangestani Fard M, Tan WS, Gothai S, Fakurazi S, Norhaizan ME, Kumar SS (2016) Role of antioxidants and natural products in inflammation. Oxid Med Cell Longev 2016:5276130. https:\/\/doi.org\/10.1155\/2016\/5276130","journal-title":"Oxid Med Cell Longev"},{"key":"1985_CR10","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1016\/j.bone.2006.09.023","volume":"40","author":"M Asagiri","year":"2007","unstructured":"Asagiri M, Takayanagi H (2007) The molecular understanding of osteoclast differentiation. Bone 40:251\u2013264. https:\/\/doi.org\/10.1016\/j.bone.2006.09.023","journal-title":"Bone"},{"key":"1985_CR12","doi-asserted-by":"publisher","first-page":"513","DOI":"10.1038\/s41574-018-0062-9","volume":"14","author":"JA Batsis","year":"2018","unstructured":"Batsis JA, Villareal DT (2018) Sarcopenic obesity in older adults: aetiology, epidemiology and treatment strategies. Nat Rev Endocrinol 14:513\u2013537. https:\/\/doi.org\/10.1038\/s41574-018-0062-9","journal-title":"Nat Rev Endocrinol"},{"key":"1985_CR13","doi-asserted-by":"publisher","first-page":"1583","DOI":"10.1016\/j.jnutbio.2011.10.012","volume":"23","author":"I Bellezza","year":"2012","unstructured":"Bellezza I, Tucci A, Galli F, Grottelli S, Mierla AL, Pilolli F, Minelli A (2012) Inhibition of NF-\u03baB nuclear translocation via HO-1 activation underlies \u03b1-tocopheryl succinate toxicity. J Nutr Biochem 23:1583\u20131591. https:\/\/doi.org\/10.1016\/j.jnutbio.2011.10.012","journal-title":"J Nutr Biochem"},{"key":"1985_CR14","doi-asserted-by":"publisher","first-page":"805","DOI":"10.1021\/tx7002883","volume":"21","author":"RV Bensasson","year":"2008","unstructured":"Bensasson RV, Zoete V, Dinkova-Kostova AT, Talalay P (2008) Two-step mechanism of induction of the gene expression of a prototypic cancer-protective enzyme by diphenols. Chem Res Toxicol 21:805\u2013812. https:\/\/doi.org\/10.1021\/tx7002883","journal-title":"Chem Res Toxicol"},{"key":"1985_CR15","doi-asserted-by":"publisher","first-page":"4926","DOI":"10.1038\/ncomms5926","volume":"5","author":"B Benyamin","year":"2014","unstructured":"Benyamin B, Esko T, Ried JS, Radhakrishnan A, Vermeulen SH, Traglia M, Gieger C, Shah S, Yu L, Feitosa MF, McEvoy BP, Johnson T, Schadt EE, Nyholt DR, Heath AC, Madden PA, Spector TD, Montgomery GW, Metspalu A, Gibson G, Wichmann HE, Kraft P, Martin NG, Whitfield JB, J\u00e4rvelin MR, Boomsma DI, Penninx BW, Visscher PM (2014) Novel loci affecting iron homeostasis and their effects in individuals at risk for hemochromatosis. Nat Commun 5:4926. https:\/\/doi.org\/10.1038\/ncomms5926","journal-title":"Nat Commun"},{"issue":"18","key":"1985_CR16","doi-asserted-by":"publisher","first-page":"1809","DOI":"10.1056\/NEJMoa067312","volume":"356","author":"DM Black","year":"2007","unstructured":"Black DM, Delmas PD, Eastell R, Reid IR, Boonen S, Cauley JA, Cosman F, Lakatos P, Leung PC, Man Z, Mautalen C, Mesenbrink P, Hu H, Caminis J, Tong K, Rosario-Jansen T, Krasnow J, Hue TF, Sellmeyer D, Eriksen EF, Cummings SR (2007) Once-yearly zoledronic acid for treatment of postmenopausal osteoporosis. N Engl J Med 356(18):1809\u20131822","journal-title":"N Engl J Med"},{"key":"1985_CR17","doi-asserted-by":"publisher","first-page":"870","DOI":"10.1142\/9789812775733_0050","volume":"2","author":"G Block","year":"2002","unstructured":"Block G, Dietrich M, Norkus E, Packer L (2002) Oxidative stress in human populations. Crit Rev Oxid Stress Aging World Sci 2:870\u2013888. https:\/\/doi.org\/10.1142\/9789812775733_0050","journal-title":"Crit Rev Oxid Stress Aging World Sci"},{"key":"1985_CR18","doi-asserted-by":"publisher","first-page":"378","DOI":"10.3390\/antiox10030378","volume":"10","author":"D Blottner","year":"2021","unstructured":"Blottner D, Capitanio D, Trautmann G, Schubert M, Tegenthoff M, Salanova M, Bottinelli R, Gelfi C (2021) Nitrosative redox homeostasis and antioxidant response defense in disused vastus lateralis muscle in long-term bedrest (Toulouse Cocktail Study). Antioxidants (Basel) 10:378. https:\/\/doi.org\/10.3390\/antiox10030378","journal-title":"Antioxidants (Basel)"},{"issue":"21","key":"1985_CR19","doi-asserted-by":"publisher","first-page":"9943","DOI":"10.1158\/0008-5472.CAN-05-0651","volume":"65","author":"P Boissy","year":"2005","unstructured":"Boissy P, Andersen TL, Abdallah BM, Kassem M, Plesner T, Delaiss\u00e9 JM (2005) Resveratrol inhibits myeloma cell growth, prevents osteoclast formation, and promotes osteoblast differentiation. Cancer Res 65(21):9943\u20139952","journal-title":"Cancer Res"},{"key":"1985_CR20","doi-asserted-by":"publisher","DOI":"10.1111\/acel.13261","volume":"19","author":"C Bose","year":"2020","unstructured":"Bose C, Alves I, Singh P, Palade P, Carvalho E, B\u00f8rsheim E, Jun JY, Hu K, Singh SP, Boerma M, Nagarkatti M, Nagarkatti P, Singh UP (2020) Sulforaphane prevents age-associated cardiac and muscular dysfunction through Nrf2 signaling. Aging Cell 19:e13261. https:\/\/doi.org\/10.1111\/acel.13261","journal-title":"Aging Cell"},{"key":"1985_CR21","doi-asserted-by":"publisher","first-page":"2335","DOI":"10.1089\/ars.2010.3534","volume":"15","author":"R Brigelius-Floh\u00e9","year":"2011","unstructured":"Brigelius-Floh\u00e9 R, Floh\u00e9 L (2011) Basic principles and emerging concepts in the redox control of transcription factors. Antioxid Redox Signal 15:2335\u20132381. https:\/\/doi.org\/10.1089\/ars.2010.3534","journal-title":"Antioxid Redox Signal"},{"key":"1985_CR22","doi-asserted-by":"publisher","first-page":"3576","DOI":"10.1002\/cmdc.202100458","volume":"16","author":"S Br\u00fcschweiler","year":"2021","unstructured":"Br\u00fcschweiler S, Fuchs JE, Bader G, Schrank E, Stefan E, Huber RG (2021) A step toward NRF2-DNA interaction inhibitors by fragment-based NMR methods. ChemMedChem 16:3576\u20133587. https:\/\/doi.org\/10.1002\/cmdc.202100458","journal-title":"ChemMedChem"},{"key":"1985_CR23","doi-asserted-by":"publisher","first-page":"1479","DOI":"10.1007\/s00784-019-03180-9","volume":"24","author":"F Camacho-Alonso","year":"2020","unstructured":"Camacho-Alonso F, Mart\u00ednez-Ortiz C, Plazas-Buend\u00eda L, Lillo-R\u00f3denas MA, Ata-Ali J, Ata-Ali F (2020) Bone union formation in the rat mandibular symphysis using hydroxyapatite with or without simvastatin: effects on healthy, diabetic, and osteoporotic rats. Clin Oral Investig 24:1479\u20131491. https:\/\/doi.org\/10.1007\/s00784-019-03180-9","journal-title":"Clin Oral Investig"},{"key":"1985_CR24","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1016\/j.freeradbiomed.2015.05.034","volume":"88","author":"P Canning","year":"2015","unstructured":"Canning P, Sorrell FJ, Bullock AN (2015) Structural basis of Keap1 interactions with Nrf2. Free Radic Biol Med 88:101\u2013107. https:\/\/doi.org\/10.1016\/j.freeradbiomed.2015.05.034","journal-title":"Free Radic Biol Med"},{"key":"1985_CR25","doi-asserted-by":"publisher","first-page":"749","DOI":"10.1016\/S0891-5849(96)00351-6","volume":"22","author":"G Cao","year":"1997","unstructured":"Cao G, Sofic E, Prior RL (1997) Antioxidant and prooxidant behavior of flavonoids: structure-activity relationships. Free Radic Biol Med 22:749\u2013760. https:\/\/doi.org\/10.1016\/S0891-5849(96)00351-6","journal-title":"Free Radic Biol Med"},{"key":"1985_CR26","doi-asserted-by":"publisher","first-page":"477","DOI":"10.1016\/j.bone.2011.08.010","volume":"50","author":"WP Cawthorn","year":"2012","unstructured":"Cawthorn WP, Bree AJ, Yao Y, Du B, Hemati N, Martinez-Santiba\u00f1ez G, MacDougald OA (2012) Wnt6, Wnt10a and Wnt10b inhibit adipogenesis and stimulate osteoblastogenesis through a \u03b2-catenin-dependent mechanism. Bone 50:477\u2013489. https:\/\/doi.org\/10.1016\/j.bone.2011.08.010","journal-title":"Bone"},{"key":"1985_CR27","doi-asserted-by":"publisher","first-page":"13943","DOI":"10.1073\/pnas.93.24.13943","volume":"93","author":"K Chan","year":"1996","unstructured":"Chan K, Lu R, Chang JC, Kan YW (1996) NRF2, a member of the NFE2 family of transcription factors, is not essential for murine erythropoiesis, growth, and development. Proc Natl Acad Sci U S A 93:13943\u201313948. https:\/\/doi.org\/10.1073\/pnas.93.24.13943","journal-title":"Proc Natl Acad Sci U S A"},{"key":"1985_CR28","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2023.115748","volume":"168","author":"J Che","year":"2023","unstructured":"Che J, Yang X, Jin Z, Xu C (2023) Nrf2: a promising therapeutic target in bone-related diseases. Biomed Pharmacother 168:115748. https:\/\/doi.org\/10.1016\/j.biopha.2023.115748","journal-title":"Biomed Pharmacother"},{"key":"1985_CR29","doi-asserted-by":"publisher","first-page":"H1862","DOI":"10.1152\/ajpheart.00651.2005","volume":"290","author":"XL Chen","year":"2006","unstructured":"Chen XL, Dodd G, Thomas S, Zhang X, Wasserman MA, Rovin BH, Kunsch C (2006) Activation of Nrf2\/ARE pathway protects endothelial cells from oxidant injury and inhibits inflammatory gene expression. Am J Physiol Heart Circ Physiol 290:H1862\u2013H1870. https:\/\/doi.org\/10.1152\/ajpheart.00651.2005","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"1985_CR30","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s41413-020-00128-8","volume":"9","author":"X Chen","year":"2021","unstructured":"Chen X, Zhu X, Wei A, Zhao L, Wang Z, Yuan M, Li J (2021) Nrf2 epigenetic derepression induced by running exercise protects against osteoporosis. Bone Res 9:1\u201310. https:\/\/doi.org\/10.1038\/s41413-020-00128-8","journal-title":"Bone Res"},{"key":"1985_CR31","doi-asserted-by":"publisher","first-page":"297","DOI":"10.2147\/JIR.S385220","volume":"16","author":"Y Chen","year":"2023","unstructured":"Chen Y, Yu J, Shi L, Zang J, Hu S, Liu C (2023) Systemic inflammation markers associated with bone mineral density in perimenopausal and postmenopausal women. J Inflamm Res 16:297\u2013309. https:\/\/doi.org\/10.2147\/JIR.S385220","journal-title":"J Inflamm Res"},{"key":"1985_CR32","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1016\/j.afos.2018.03.003","volume":"4","author":"CL Cheung","year":"2018","unstructured":"Cheung CL, Ang SB, Chadha M, Chow ESL, Chung YS, Hew FL, Lau EY, Ng H, Takeuchi Y, Tsai KS, Mithal A, Chan DC (2018) An updated hip fracture projection in Asia: the Asian Federation of Osteoporosis Societies study. Osteoporos Sarcopenia 4:16\u201321. https:\/\/doi.org\/10.1016\/j.afos.2018.03.003","journal-title":"Osteoporos Sarcopenia"},{"key":"1985_CR33","doi-asserted-by":"publisher","first-page":"138","DOI":"10.1164\/rccm.200804-535OC","volume":"179","author":"HY Cho","year":"2009","unstructured":"Cho HY, Imani F, Miller-DeGraff L, Walters D, Melendi GA, Yamamoto M, Kleeberger SR (2009) Antiviral activity of Nrf2 in a murine model of respiratory syncytial virus disease. Am J Respir Crit Care Med 179:138\u2013150. https:\/\/doi.org\/10.1164\/rccm.200804-535OC","journal-title":"Am J Respir Crit Care Med"},{"key":"1985_CR35","doi-asserted-by":"publisher","first-page":"431","DOI":"10.1016\/j.tibs.2024.01.012","volume":"49","author":"D Clarisse","year":"2024","unstructured":"Clarisse D, Van Moortel L, Van Leene C, Vanholder R, De Smet R, De Bosscher K (2024) Glucocorticoid receptor signaling: intricacies and therapeutic opportunities. Trends Biochem Sci 49:431\u2013444. https:\/\/doi.org\/10.1016\/j.tibs.2024.01.012","journal-title":"Trends Biochem Sci"},{"key":"1985_CR36","doi-asserted-by":"publisher","first-page":"S131","DOI":"10.2215\/CJN.04151206","volume":"3","author":"B Clarke","year":"2008","unstructured":"Clarke B (2008) Normal bone anatomy and physiology. Clin J Am Soc Nephrol 3:S131. https:\/\/doi.org\/10.2215\/CJN.04151206","journal-title":"Clin J Am Soc Nephrol"},{"issue":"2","key":"1985_CR37","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1016\/j.canlet.2008.04.018","volume":"269","author":"JD Clarke","year":"2008","unstructured":"Clarke JD, Dashwood RH, Ho E (2008) Multi-targeted prevention of cancer by sulforaphane. Cancer Lett 269(2):291\u2013304. https:\/\/doi.org\/10.1016\/j.canlet.2008.04.018","journal-title":"Cancer Lett"},{"key":"1985_CR38","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1007\/s12020-018-1588-2","volume":"61","author":"J Compston","year":"2018","unstructured":"Compston J (2018) Glucocorticoid-induced osteoporosis: an update. Endocrine 61:7\u201316. https:\/\/doi.org\/10.1007\/s12020-018-1588-2","journal-title":"Endocrine"},{"key":"1985_CR39","doi-asserted-by":"publisher","first-page":"579","DOI":"10.1590\/S0004-27302006000400023","volume":"50","author":"J Compston","year":"2006","unstructured":"Compston J (2006) Bone quality: what is it and how is it measured? Arquivos Brasileiros De Endocrinologia Metabologia 50:579\u2013585. https:\/\/doi.org\/10.1590\/S0004-27302006000400023","journal-title":"Arquivos Brasileiros De Endocrinologia Metabologia"},{"key":"1985_CR40","doi-asserted-by":"publisher","first-page":"462","DOI":"10.1093\/toxsci\/kfu080","volume":"140","author":"IM Copple","year":"2014","unstructured":"Copple IM, Shelton LM, Walsh J, Kratschmar DV, Lister A, Odermatt A, Goldring CE, Kitteringham NR, Park BK (2014) Chemical tuning enhances both potency toward Nrf2 and in vitro therapeutic index of triterpenoids. Toxicol Sci 140:462\u2013469. https:\/\/doi.org\/10.1093\/toxsci\/kfu080","journal-title":"Toxicol Sci"},{"key":"1985_CR42","doi-asserted-by":"publisher","first-page":"661","DOI":"10.1159\/000457945","volume":"41","author":"P Dai","year":"2017","unstructured":"Dai P, Mao Y, Sun X, Li X, Muhammad I, Gu W, Zhang X (2017) Attenuation of oxidative stress-induced osteoblast apoptosis by curcumin is associated with preservation of mitochondrial functions and increased Akt-GSK3\u03b2 signaling. Cell Physiol Biochem 41:661\u2013677. https:\/\/doi.org\/10.1159\/000457945","journal-title":"Cell Physiol Biochem"},{"key":"1985_CR43","doi-asserted-by":"publisher","first-page":"30","DOI":"10.2174\/1871524911313010005","volume":"13","author":"F Dajas","year":"2013","unstructured":"Dajas F, Andres AJ, Florencia A, Ferreira M, Medina C (2013) Neuroprotective actions of flavones and flavonols: mechanisms and relationship to flavonoid structural features. Cent Nerv Syst Agents Med Chem 13:30\u201335. https:\/\/doi.org\/10.2174\/1871524911313010005","journal-title":"Cent Nerv Syst Agents Med Chem"},{"key":"1985_CR44","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmb.2021.167336","volume":"434","author":"A David","year":"2022","unstructured":"David A, Islam S, Tankhilevich E, Sternberg MJE (2022) The alphafold database of protein structures: a biologist\u2019s guide. J Mol Biol 434:167336. https:\/\/doi.org\/10.1016\/j.jmb.2021.167336","journal-title":"J Mol Biol"},{"key":"1985_CR45","doi-asserted-by":"publisher","first-page":"1779","DOI":"10.1021\/tx050217c","volume":"18","author":"AT Dinkova-Kostova","year":"2005","unstructured":"Dinkova-Kostova AT, Holtzclaw WD, Kensler TW (2005) The role of Keap1 in cellular protective responses. Chem Res Toxicol 18:1779\u20131791. https:\/\/doi.org\/10.1021\/tx050217c","journal-title":"Chem Res Toxicol"},{"key":"1985_CR46","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1186\/1475-2891-11-79","volume":"11","author":"RA DiSilvestro","year":"2012","unstructured":"DiSilvestro RA, Joseph E, Zhao S, Bomser J (2012) Diverse effects of a low dose supplement of lipidated curcumin in healthy middle-aged people. Nutr J 11:79","journal-title":"Nutr J"},{"key":"1985_CR47","doi-asserted-by":"publisher","first-page":"322","DOI":"10.3390\/ph17030322","volume":"17","author":"M Dong","year":"2024","unstructured":"Dong M, Lu J, Xue H, Sun Y, Liu S, Tian L, Yang H, Wang Q, Fan X (2024) Anthocyanins from Lycium ruthenicum Murray mitigate cadmium-induced oxidative stress and testicular toxicity by activating the Keap1\/Nrf2 signaling pathway. Pharmaceuticals 17:322. https:\/\/doi.org\/10.3390\/ph17030322","journal-title":"Pharmaceuticals"},{"key":"1985_CR48","doi-asserted-by":"publisher","first-page":"889226","DOI":"10.3389\/fphar.2022.889226","volume":"13","author":"C Duan","year":"2022","unstructured":"Duan C, Wang H, Jiao D, Xu Z, Qiu L, Song L, Wang Y (2022) Curcumin restrains oxidative stress of after intracerebral hemorrhage in rat by activating the Nrf2\/HO-1 pathway. Front Pharmacol 13:889226. https:\/\/doi.org\/10.3389\/fphar.2022.889226","journal-title":"Front Pharmacol"},{"issue":"3","key":"1985_CR49","doi-asserted-by":"publisher","first-page":"322","DOI":"10.3390\/antiox10030322","volume":"10","author":"G Duranti","year":"2021","unstructured":"Duranti G, Ceci R, Patrizio F, Sgro P, Sabatini S, Bazzucchi I, Di Luigi L, Sabatini S, Di Luigi L (2021a) Moringa oleifera leaf extract modulates redox homeostasis and increases antioxidant enzymes in skeletal muscle cells. Antioxidants (Basel) 10(3):322. https:\/\/doi.org\/10.3390\/antiox10030322","journal-title":"Antioxidants (Basel)"},{"key":"1985_CR50","doi-asserted-by":"publisher","first-page":"5041","DOI":"10.3390\/molecules26165041","volume":"26","author":"G Duranti","year":"2021","unstructured":"Duranti G, Maldini M, Crognale D, Horner DS, Sabatini S, Ceci R (2021b) Moringa oleifera leaf extract upregulates Nrf2\/HO-1 expression and ameliorates redox status in C2C12 skeletal muscle cells. Molecules 26:5041. https:\/\/doi.org\/10.3390\/molecules26165041","journal-title":"Molecules"},{"key":"1985_CR51","doi-asserted-by":"publisher","first-page":"16069","DOI":"10.1038\/nrdp.2016.69","volume":"2","author":"R Eastell","year":"2016","unstructured":"Eastell R, O\u2019Neill TW, Hofbauer LC, Langdahl B, Reid IR, Gold DT, Cummings SR (2016) Postmenopausal osteoporosis. Nat Rev Dis Primers 2:16069. https:\/\/doi.org\/10.1038\/nrdp.2016.69","journal-title":"Nat Rev Dis Primers"},{"issue":"2","key":"1985_CR52","first-page":"6306","volume":"19","author":"EFSA Nda Panel (EFSA Panel on Dietetic Products, Nutrition and Allergies)","year":"2021","unstructured":"EFSA Nda Panel (EFSA Panel on Dietetic Products, Nutrition and Allergies) (2021) Scientific and technical guidance for the preparation and presentation of a health claim application. EFSA J 19(2):6306","journal-title":"EFSA J"},{"key":"1985_CR53","doi-asserted-by":"publisher","first-page":"1083","DOI":"10.1152\/physrev.00014.2017","volume":"98","author":"F Elefteriou","year":"2018","unstructured":"Elefteriou F (2018) Impact of the autonomic nervous system on the skeleton. Physiol Rev 98:1083\u20131112. https:\/\/doi.org\/10.1152\/physrev.00014.2017","journal-title":"Physiol Rev"},{"key":"1985_CR54","doi-asserted-by":"publisher","first-page":"46208","DOI":"10.1038\/srep46208","volume":"7","author":"EF Fang","year":"2017","unstructured":"Fang EF, Waltz TB, Kassahun H, Lu Q, Kerr JS, Morevati M, Fivenson E, Wollman BN, Marosi K, Wilson MA, Iser WB, Mich\u00e1n S, Becker KG, Becker DM, Mattson MP, Navas P, Bohr VA (2017) Tomatidine enhances lifespan and healthspan in C. elegans through mitophagy induction via the SKN-1\/Nrf2 pathway. Sci Rep 7:46208. https:\/\/doi.org\/10.1038\/srep46208","journal-title":"Sci Rep"},{"key":"1985_CR55","doi-asserted-by":"publisher","first-page":"1072","DOI":"10.1038\/nm.4385","volume":"23","author":"JN Farr","year":"2017","unstructured":"Farr JN, Xu M, Weivoda MM, Monroe DG, Fraser DG, Onken JL, Negley BA, Sfeir JG, Ogrodnik MB, Hachfeld CM, LeBrasseur NK, Drake MT, Tchkonia T, Pignolo RJ, Kirkland JL, Khosla S (2017) Targeting cellular senescence prevents age-related bone loss in mice. Nat Med 23:1072\u20131079. https:\/\/doi.org\/10.1038\/nm.4385","journal-title":"Nat Med"},{"key":"1985_CR56","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1146\/annurev-pathol-011110-130203","volume":"6","author":"X Feng","year":"2011","unstructured":"Feng X, McDonald JM (2011) Disorders of bone remodeling. Annu Rev Pathol 6:121\u2013145. https:\/\/doi.org\/10.1146\/annurev-pathol-011110-130203","journal-title":"Annu Rev Pathol"},{"key":"1985_CR58","doi-asserted-by":"publisher","first-page":"2375","DOI":"10.1002\/ptr.7456","volume":"36","author":"K Fu","year":"2022","unstructured":"Fu K, Zhou H, Wang C, Yang J, Chen Z, Wu M, Song X, Zhang S, Zhao Y, Wang L, Wang H (2022) A review: pharmacology and pharmacokinetics of schisandrin A. Phytother Res 36:2375\u20132393. https:\/\/doi.org\/10.1002\/ptr.7456","journal-title":"Phytother Res"},{"key":"1985_CR59","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s00441-021-03489-6","volume":"386","author":"G Giorgi","year":"2021","unstructured":"Giorgi G, Del Re B (2021) Epigenetic dysregulation in various types of cells exposed to extremely low-frequency magnetic fields. Cell Tissue Res 386:1\u201315. https:\/\/doi.org\/10.1007\/s00441-021-03489-6","journal-title":"Cell Tissue Res"},{"issue":"4","key":"1985_CR60","doi-asserted-by":"publisher","first-page":"627","DOI":"10.1016\/j.jgr.2019.08.004","volume":"44","author":"GY Go","year":"2020","unstructured":"Go GY, Lee SJ, Kim JS, Song Y, Lee SH, Hwang GS, Park JH (2020a) Ginsenoside Rb1 improves age-related skeletal muscle loss by regulating SIRT1 and Nrf2 signaling pathways in aged mice. J Ginseng Res 44(4):627\u2013637. https:\/\/doi.org\/10.1016\/j.jgr.2019.08.004","journal-title":"J Ginseng Res"},{"key":"1985_CR61","doi-asserted-by":"publisher","first-page":"435","DOI":"10.1016\/j.jgr.2019.01.007","volume":"44","author":"GY Go","year":"2020","unstructured":"Go GY, Jo A, Seo DW, Kim HJ, Jeon JH, Kim WS, Kang JH, Choi KC (2020b) Ginsenoside Rb1 and Rb2 upregulate Akt\/mTOR signaling\u2013mediated muscular hypertrophy and myoblast differentiation. J Ginseng Res 44:435\u2013441. https:\/\/doi.org\/10.1016\/j.jgr.2019.01.007","journal-title":"J Ginseng Res"},{"key":"1985_CR62","doi-asserted-by":"publisher","first-page":"9497","DOI":"10.1007\/s11033-023-08793-8","volume":"50","author":"P Gopinath","year":"2023","unstructured":"Gopinath P, Oviya RP, Gopisetty G (2023) Oestrogen receptor-independent actions of oestrogen in cancer. Mol Biol Rep 50:9497\u20139509. https:\/\/doi.org\/10.1007\/s11033-023-08793-8","journal-title":"Mol Biol Rep"},{"key":"1985_CR63","doi-asserted-by":"publisher","first-page":"9599","DOI":"10.1038\/s41598-017-09943-2","volume":"7","author":"Y Guo","year":"2017","unstructured":"Guo Y, Sun J, Li T, Tang K, Yu B, Zhang L (2017) Melatonin ameliorates restraint stress-induced oxidative stress and apoptosis in testicular cells via NF-\u03baB\/iNOS and Nrf2\/HO-1 signaling pathway. Sci Rep 7:9599. https:\/\/doi.org\/10.1038\/s41598-017-09943-2","journal-title":"Sci Rep"},{"key":"1985_CR64","first-page":"1","volume-title":"Free radicals and aging","author":"D Harman","year":"1992","unstructured":"Harman D (1992) Free radical theory of aging: History. In: Emerit I, Chance B (eds) Free radicals and aging. Birkh\u00e4user, Basel, pp 1\u201310"},{"key":"1985_CR65","doi-asserted-by":"publisher","first-page":"124","DOI":"10.1007\/978-3-0348-9116-5_11","volume-title":"Free Radicals: from Basic Science to Medicine","author":"D Harman","year":"1993","unstructured":"Harman D (1993) Free radical theory of aging. In: Poli G, Albano E, Dianzani MU (eds) Free Radicals: from Basic Science to Medicine. Birkh\u00e4user, Basel, pp 124\u2013143"},{"issue":"4","key":"1985_CR66","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1016\/j.tibs.2014.02.002","volume":"39","author":"JD Hayes","year":"2014","unstructured":"Hayes JD, Dinkova-Kostova AT (2014) The Nrf2 regulatory network provides an interface between redox and intermediary metabolism. Trends Biochem Sci 39(4):199\u2013218. https:\/\/doi.org\/10.1016\/j.tibs.2014.02.002","journal-title":"Trends Biochem Sci"},{"key":"1985_CR68","doi-asserted-by":"publisher","first-page":"1713","DOI":"10.1089\/ars.2010.3221","volume":"13","author":"JD Hayes","year":"2010","unstructured":"Hayes JD, McMahon M, Chowdhry S, Dinkova-Kostova AT (2010) Cancer chemoprevention mechanisms mediated through the Keap1\u2013Nrf2 pathway. Antioxid Redox Signal 13:1713\u20131748. https:\/\/doi.org\/10.1089\/ars.2010.3221","journal-title":"Antioxid Redox Signal"},{"key":"1985_CR69","doi-asserted-by":"publisher","first-page":"32008","DOI":"10.1074\/jbc.M104794200","volume":"276","author":"E Heiss","year":"2001","unstructured":"Heiss E, Herhaus C, Klimo K, Bartsch H, Gerh\u00e4user C (2001) Nuclear factor \u03baB is a molecular target for sulforaphane-mediated anti-inflammatory mechanisms. J Biol Chem 276:32008\u201332015. https:\/\/doi.org\/10.1074\/jbc.M104794200","journal-title":"J Biol Chem"},{"key":"1985_CR71","doi-asserted-by":"publisher","first-page":"18015","DOI":"10.1074\/jbc.M600603200","volume":"281","author":"E Hinoi","year":"2006","unstructured":"Hinoi E, Fujimori S, Wang L, Hojo H, Uno K, Yoneda Y (2006) Nrf2 negatively regulates osteoblast differentiation via interfering with Runx2-dependent transcriptional activation. J Biol Chem 281:18015\u201318024. https:\/\/doi.org\/10.1074\/jbc.M600603200","journal-title":"J Biol Chem"},{"key":"1985_CR73","doi-asserted-by":"publisher","first-page":"775","DOI":"10.1111\/jcmm.13973","volume":"23","author":"YC Hseu","year":"2019","unstructured":"Hseu YC, Yang TY, Li ML, Chen YC, Lin YC, Tsai YC, Fu KT, Wang HM, Hsu LS, Kumar KJ, Huang C-Y (2019) Chalcone flavokawain A attenuates TGF-\u03b21-induced fibrotic pathology via inhibition of ROS\/Smad3 signaling pathways and induction of Nrf2\/ARE-mediated antioxidant genes in vascular smooth muscle cells. J Cell Mol Med 23:775\u2013788. https:\/\/doi.org\/10.1111\/jcmm.13973","journal-title":"J Cell Mol Med"},{"key":"1985_CR74","doi-asserted-by":"publisher","first-page":"421","DOI":"10.1146\/annurev.ento.50.071803.130409","volume":"50","author":"KA Hughes","year":"2005","unstructured":"Hughes KA, Reynolds RM (2005) Evolutionary and mechanistic theories of aging. Annu Rev Entomol 50:421\u2013445. https:\/\/doi.org\/10.1146\/annurev.ento.50.071803.130409","journal-title":"Annu Rev Entomol"},{"key":"1985_CR75","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/7432797","volume":"2016","author":"T Hussain","year":"2016","unstructured":"Hussain T, Tan B, Yin Y, Blachier F, Tossou MCB, Rahu N (2016) Oxidative stress and inflammation: what polyphenols can do for us? Oxid Med Cell Longev 2016:7432797. https:\/\/doi.org\/10.1155\/2016\/7432797","journal-title":"Oxid Med Cell Longev"},{"key":"1985_CR76","doi-asserted-by":"publisher","first-page":"3242","DOI":"10.1038\/srep03242","volume":"3","author":"YJ Hwang","year":"2013","unstructured":"Hwang YJ, Lee EW, Song J, Ha SA, Lee H, Kim HR, Kim J (2013) MafK positively regulates NF-\u03baB activity by enhancing CBP-mediated p65 acetylation. Sci Rep 3:3242. https:\/\/doi.org\/10.1038\/srep03242","journal-title":"Sci Rep"},{"key":"1985_CR77","doi-asserted-by":"publisher","first-page":"789","DOI":"10.1016\/j.freeradbiomed.2013.08.005","volume":"65","author":"S Hyeon","year":"2013","unstructured":"Hyeon S, Lee H, Yang Y, Jeong W (2013a) Nrf2 deficiency induces oxidative stress and promotes RANKL-induced osteoclast differentiation. Free Radic Biol Med 65:789\u2013799. https:\/\/doi.org\/10.1016\/j.freeradbiomed.2013.08.005","journal-title":"Free Radic Biol Med"},{"key":"1985_CR78","doi-asserted-by":"publisher","first-page":"789","DOI":"10.1016\/j.freeradbiomed.2013.08.005","volume":"65","author":"S Hyeon","year":"2013","unstructured":"Hyeon S, Lee H, Yang Y, Jeong W, Cheon YH, Kim JY, Kim JH, Choi JY, Choi SY, Lee KJ, Kim HH (2013b) Nrf2 deficiency aggravates bone loss in OVX-induced osteoporosis by increasing oxidative stress and RANKL expression. Free Radic Biol Med 65:789\u2013799","journal-title":"Free Radic Biol Med"},{"key":"1985_CR79","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/726590","volume":"2014","author":"L Ib\u00e1\u00f1ez","year":"2014","unstructured":"Ib\u00e1\u00f1ez L, Ferr\u00e1ndiz ML, Brines R, Guede D, P\u00e9rez-C\u00e1rceles MD, Alcaraz MJ (2014) Effects of Nrf2 deficiency on bone microarchitecture in an experimental model of osteoporosis. Oxid Med Cell Longev 2014:726590. https:\/\/doi.org\/10.1155\/2014\/726590","journal-title":"Oxid Med Cell Longev"},{"issue":"2","key":"1985_CR80","doi-asserted-by":"publisher","first-page":"313","DOI":"10.1006\/bbrc.1997.6943","volume":"236","author":"K Itoh","year":"1997","unstructured":"Itoh K, Chiba T, Takahashi S, Ishii T, Igarashi K, Katoh Y, Oyake T, Hayashi N, Satoh K, Hatayama I, Yamamoto M, Nabeshima Y (1997) An Nrf2\/Small Maf heterodimer mediates the induction of phase II detoxifying enzyme genes through antioxidant response elements. Biochem Biophys Res Commun 236(2):313\u2013322. https:\/\/doi.org\/10.1006\/bbrc.1997.6943","journal-title":"Biochem Biophys Res Commun"},{"key":"1985_CR81","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1101\/gad.13.1.76","volume":"13","author":"K Itoh","year":"1999","unstructured":"Itoh K, Wakabayashi N, Katoh Y, Ishii T, Igarashi K, Engel JD, Yamamoto M (1999) Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domain. Genes Dev 13:76\u201386. https:\/\/doi.org\/10.1101\/gad.13.1.76","journal-title":"Genes Dev"},{"key":"1985_CR82","doi-asserted-by":"publisher","first-page":"1904","DOI":"10.1128\/iai.01618-13","volume":"82","author":"A Izawa","year":"2014","unstructured":"Izawa A, Ishihara Y, Mizutani H, Tanaka I, Kaibuchi K, Kitajima I, Nishihara H (2014) Inflammatory bone loss in experimental periodontitis induced by Aggregatibacter actinomycetemcomitans in interleukin-1 receptor antagonist knockout mice. Infect Immun 82:1904\u20131913. https:\/\/doi.org\/10.1128\/iai.01618-13","journal-title":"Infect Immun"},{"key":"1985_CR84","doi-asserted-by":"publisher","first-page":"424","DOI":"10.1016\/j.bone.2012.10.017","volume":"52","author":"J Jia","year":"2013","unstructured":"Jia J, Yao W, Amugongo S, Lin X, Ma Y, Suzuki K, Li X, Qin L (2013) Prolonged alendronate treatment prevents the decline in serum TGF-\u03b21 levels and reduces cortical bone strength in long-term estrogen deficiency rat model. Bone 52:424\u2013432. https:\/\/doi.org\/10.1016\/j.bone.2012.10.017","journal-title":"Bone"},{"key":"1985_CR85","doi-asserted-by":"publisher","first-page":"333","DOI":"10.1038\/ki.2013.343","volume":"85","author":"T Jiang","year":"2014","unstructured":"Jiang T, Tian F, Zheng H, Whitman SA, Lin Y, Zhang Z, Zhang DD (2014) Nrf2 suppresses lupus nephritis through inhibition of oxidative injury and the NF-\u03baB-mediated inflammatory response. Kidney Int 85:333\u2013343. https:\/\/doi.org\/10.1038\/ki.2013.343","journal-title":"Kidney Int"},{"key":"1985_CR86","doi-asserted-by":"publisher","first-page":"851","DOI":"10.1111\/j.1474-9726.2010.00616.x","volume":"9","author":"RL Jilka","year":"2010","unstructured":"Jilka RL, Almeida M, Ambrogini E, Han L, Roberson PK, Weinstein RS, Manolagas SC (2010) Decreased oxidative stress and greater bone anabolism in the aged, when compared to the young, murine skeleton with parathyroid hormone administration. Aging Cell 9:851\u2013867. https:\/\/doi.org\/10.1111\/j.1474-9726.2010.00616.x","journal-title":"Aging Cell"},{"key":"1985_CR87","doi-asserted-by":"publisher","first-page":"138","DOI":"10.1016\/j.fct.2016.12.031","volume":"100","author":"SW Jin","year":"2017","unstructured":"Jin SW, Hwang YP, Choi CY, Han EH, Park BH, Lee HS, Kang KW (2017) Protective effect of rutaecarpine against t-BHP-induced hepatotoxicity by upregulating antioxidant enzymes via the CaMKII-Akt and Nrf2\/ARE pathways. Food Chem Toxicol 100:138\u2013148. https:\/\/doi.org\/10.1016\/j.fct.2016.12.031","journal-title":"Food Chem Toxicol"},{"key":"1985_CR88","doi-asserted-by":"publisher","first-page":"1161S","DOI":"10.3945\/ajcn.112.034611","volume":"96","author":"EJ Johnson","year":"2012","unstructured":"Johnson EJ (2012) A possible role for lutein and zeaxanthin in cognitive function in the elderly. Am J Clin Nutr 96:1161S-1165S. https:\/\/doi.org\/10.3945\/ajcn.112.034611","journal-title":"Am J Clin Nutr"},{"key":"1985_CR89","doi-asserted-by":"publisher","first-page":"1","DOI":"10.18553\/jmcp.2006.12.S6-A.1","volume":"12","author":"HK Kamel","year":"2006","unstructured":"Kamel HK, O\u2019Connell MB, Gold DT (2006) Therapeutic options in the prevention and treatment of postmenopausal osteoporosis. J Manag Care Pharm 12:1\u201328. https:\/\/doi.org\/10.18553\/jmcp.2006.12.S6-A.1","journal-title":"J Manag Care Pharm"},{"key":"1985_CR92","doi-asserted-by":"publisher","first-page":"23009","DOI":"10.1074\/jbc.M113.478545","volume":"288","author":"H Kanzaki","year":"2013","unstructured":"Kanzaki H, Shinohara F, Kajiya M, Kodama T (2013) The Keap1\/Nrf2 protein axis plays a role in osteoclast differentiation by regulating intracellular reactive oxygen species signaling. J Biol Chem 288:23009\u201323020. https:\/\/doi.org\/10.1074\/jbc.M113.478545","journal-title":"J Biol Chem"},{"key":"1985_CR94","doi-asserted-by":"publisher","first-page":"S45","DOI":"10.1016\/S0020-1383(08)70015-9","volume":"39","author":"NC Keramaris","year":"2008","unstructured":"Keramaris NC, Calori GM, Nikolaou VS, Schemitsch EH, Giannoudis PV (2008) Fracture vascularity and bone healing: a systematic review of the role of VEGF. Injury 39:S45\u2013S57. https:\/\/doi.org\/10.1016\/S0020-1383(08)70015-9","journal-title":"Injury"},{"issue":"10","key":"1985_CR95","doi-asserted-by":"publisher","first-page":"1479","DOI":"10.1359\/jbmr.0707onj","volume":"22","author":"S Khosla","year":"2007","unstructured":"Khosla S, Burr D, Cauley J, Dempster DW, Ebeling PR, Felsenberg D, Gagel RF, Gilsanz V, Guise TA, Koka S, McCauley LK, McGowan J, McKee MD, Mohla S, Pendrys DG, Raisz LG, Ruggiero SL, Shafer DM, Shum L, Silverman SL, Van Poznak CH, Watts N, Woo SB (2007) Bisphosphonate-associated osteonecrosis of the jaw: report of a task force of the American Society for Bone and Mineral Research. J Bone Miner Res 22(10):1479\u20131491","journal-title":"J Bone Miner Res"},{"key":"1985_CR96","doi-asserted-by":"publisher","first-page":"40294","DOI":"10.1074\/jbc.M110.126821","volume":"285","author":"KS Kim","year":"2010","unstructured":"Kim KS, Choi HW, Yoon HE, Kim IY (2010) Reactive oxygen species generated by NADPH oxidase 2 and 4 are required for chondrogenic differentiation. J Biol Chem 285:40294\u201340302. https:\/\/doi.org\/10.1074\/jbc.M110.126821","journal-title":"J Biol Chem"},{"key":"1985_CR98","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/boneres.2014.33","volume":"2","author":"JH Kim","year":"2014","unstructured":"Kim JH, Singhal V, Biswal S, Thimmulappa RK, DiGirolamo DJ, Ryoo HM, Stein GS, Lian JB, Johnson RS, Zhang DD, Choi EY (2014) Nrf2 is required for normal postnatal bone acquisition in mice. Bone Res 2:1\u201310. https:\/\/doi.org\/10.1038\/boneres.2014.33","journal-title":"Bone Res"},{"key":"1985_CR99","doi-asserted-by":"publisher","first-page":"11933","DOI":"10.1038\/s41598-020-68890-7","volume":"10","author":"HN Kim","year":"2020","unstructured":"Kim HN, Ponte F, Nookaew I, Matlock BK, Kim SH, Song Y, Almeida M, Ambrogini E, Han L, Onal M, Xiong J, Weinstein RS, Manolagas SC, O\u2019Brien CA (2020) Estrogens decrease osteoclast number by attenuating mitochondrial oxidative phosphorylation and ATP production in early osteoclast precursors. Sci Rep 10:11933. https:\/\/doi.org\/10.1038\/s41598-020-68890-7","journal-title":"Sci Rep"},{"key":"1985_CR100","doi-asserted-by":"publisher","first-page":"11624","DOI":"10.1038\/ncomms11624","volume":"7","author":"EH Kobayashi","year":"2016","unstructured":"Kobayashi EH, Suzuki T, Funayama R, Nagashima T, Hayashi M, Sekine H, Tanaka N, Moriguchi T, Motohashi H, Nakayama K, Yamamoto M (2016) Nrf2 suppresses macrophage inflammatory response by blocking proinflammatory cytokine transcription. Nat Commun 7:11624. https:\/\/doi.org\/10.1038\/ncomms11624","journal-title":"Nat Commun"},{"key":"1985_CR102","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1007\/s11010-015-2559-z","volume":"410","author":"SH Kook","year":"2015","unstructured":"Kook SH, Kim KA, Ji H, Lee JC (2015) Irradiation inhibits the maturation and mineralization of osteoblasts via the activation of Nrf2\/HO-1 pathway. Mol Cell Biochem 410:255\u2013266. https:\/\/doi.org\/10.1007\/s11010-015-2559-z","journal-title":"Mol Cell Biochem"},{"key":"1985_CR104","doi-asserted-by":"publisher","first-page":"263","DOI":"10.3390\/antiox11020263","volume":"11","author":"Y Kubo","year":"2022","unstructured":"Kubo Y, Beckmann R, Fragoulis A, Lemke J, Pufe T, Rueger JM, Seekamp A, Hoffmann M, Jahr H (2022) Nrf2\/ARE signaling directly regulates SOX9 to potentially alter age-dependent cartilage degeneration. Antioxidants (Basel) 11:263. https:\/\/doi.org\/10.3390\/antiox11020263","journal-title":"Antioxidants (Basel)"},{"key":"1985_CR105","doi-asserted-by":"publisher","first-page":"42863","DOI":"10.1074\/jbc.M111.286880","volume":"286","author":"N Kweider","year":"2011","unstructured":"Kweider N, Fragoulis A, Rosen C, Pecks U, Rath W, Pufe T, Wruck CJ (2011) Interplay between vascular endothelial growth factor (VEGF) and nuclear factor erythroid 2-related factor-2 (Nrf2): implications for preeclampsia. J Biol Chem 286:42863\u201342872. https:\/\/doi.org\/10.1074\/jbc.M111.286880","journal-title":"J Biol Chem"},{"key":"1985_CR106","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1016\/S0092-8674(00)81569-X","volume":"93","author":"DL Lacey","year":"1998","unstructured":"Lacey DL, Timms E, Tan H-L, Kelley MJ, Dunstan CR, Burgess T, Elliott R, Colombero A, Elliott G, Scully S, Hsu H, Sullivan J, Hawkins N, Davy E, Capparelli C, Eli A, Qian YX, Kaufman S, Sarosi I, Shalhoub V, Senaldi G, Guo J, Delaney J, Boyle WJ (1998) Osteoprotegerin ligand is a cytokine that regulates osteoclast differentiation and activation. Cell 93:165\u2013176","journal-title":"Cell"},{"key":"1985_CR107","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1186\/1472-6882-6-10","volume":"6","author":"CD Lao","year":"2006","unstructured":"Lao CD, Ruffin MT, Normolle D, Heath DD, Murray SI, Bailey JM, Boggs ME, Crowell J, Rock CL, Brenner DE (2006) Dose escalation of a curcuminoid formulation. BMC Complement Altern Med 6:10. https:\/\/doi.org\/10.1186\/1472-6882-6-10","journal-title":"BMC Complement Altern Med"},{"key":"1985_CR108","doi-asserted-by":"publisher","first-page":"915","DOI":"10.1172\/JCI18859","volume":"112","author":"JM Lean","year":"2003","unstructured":"Lean JM, Davies JT, Fuller K, Jagger CJ, Kirstein B, Partington GA, Urry ZL, Chambers TJ (2003) A crucial role for thiol antioxidants in estrogen-deficiency bone loss. J Clin Invest 112:915\u2013923. https:\/\/doi.org\/10.1172\/JCI18859","journal-title":"J Clin Invest"},{"key":"1985_CR109","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1016\/j.canlet.2004.09.042","volume":"224","author":"JS Lee","year":"2005","unstructured":"Lee JS, Surh YJ (2005) Nrf2 as a novel molecular target for chemoprevention. Cancer Lett 224:171\u2013184. https:\/\/doi.org\/10.1016\/j.canlet.2004.09.042","journal-title":"Cancer Lett"},{"key":"1985_CR111","doi-asserted-by":"publisher","first-page":"870","DOI":"10.1016\/j.bcp.2007.06.034","volume":"74","author":"SH Lee","year":"2007","unstructured":"Lee SH, Sohn DH, Jin XY, Jung JY, Lee YM, Son KH, Chang HW, Kang SS, Kim HP (2007) 2\u2032,4\u2032,6\u2032-Tris(methoxymethoxy) chalcone protects against trinitrobenzene sulfonic acid-induced colitis and blocks tumor necrosis factor-\u03b1-induced intestinal epithelial inflammation via heme oxygenase 1-dependent and independent pathways. Biochem Pharmacol 74:870\u2013880. https:\/\/doi.org\/10.1016\/j.bcp.2007.06.034","journal-title":"Biochem Pharmacol"},{"key":"1985_CR112","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1016\/j.molcel.2009.07.025","volume":"36","author":"DF Lee","year":"2009","unstructured":"Lee DF, Kuo HP, Liu M, Chou CK, Xia W, Du Y, Shen J, Chen C-T, Huo L, Hsu MC, Li CW, Ding Q, Liao TL, Yeh YH, Lee HJ, Wu JY, Lin AC, Wang YN, Chang WC, Chen CH, Sahin AA, Hortobagyi GN, Hung MC (2009) KEAP1 E3 ligase-mediated downregulation of NF-\u03baB signaling by targeting IKK\u03b2. Mol Cell 36:131\u2013140. https:\/\/doi.org\/10.1016\/j.molcel.2009.07.025","journal-title":"Mol Cell"},{"issue":"2","key":"1985_CR113","first-page":"177","volume":"26","author":"DE Lee","year":"2018","unstructured":"Lee DE, Lee SH, Noh AL, Jang EJ, Park JH, Kim DK, Lee SY, Kim CS (2018) Protective effect of pterostilbene against bone loss in ovariectomized mice through the regulation of osteoclastogenesis and osteoblastogenesis. Biomol Ther (Seoul) 26(2):177\u2013183","journal-title":"Biomol Ther (Seoul)"},{"key":"1985_CR114","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1016\/j.jff.2015.06.054","volume":"18","author":"SW Lei","year":"2015","unstructured":"Lei SW, Cui G, Leung GPH, Wu WKK, Cheng CHK, Chan WK, Kong SK (2015) Icaritin protects against oxidative stress-induced injury in cardiac H9c2 cells via Akt\/Nrf2\/HO-1 and calcium signalling pathways. J Funct Foods 18:213\u2013223. https:\/\/doi.org\/10.1016\/j.jff.2015.06.054","journal-title":"J Funct Foods"},{"key":"1985_CR115","doi-asserted-by":"publisher","first-page":"915","DOI":"10.3390\/antiox12040915","volume":"12","author":"G Le\u00f3n-Reyes","year":"2023","unstructured":"Le\u00f3n-Reyes G, Argoty-Pantoja AD, Becerra-Cervera A, L\u00f3pez-Montoya P, Rivera-Paredez B, Vel\u00e1zquez-Cruz R (2023) Oxidative-stress-related genes in osteoporosis: a systematic review. Antioxidants (Basel) 12:915. https:\/\/doi.org\/10.3390\/antiox12040915","journal-title":"Antioxidants (Basel)"},{"issue":"3","key":"1985_CR118","doi-asserted-by":"publisher","first-page":"167","DOI":"10.3390\/nu8030167","volume":"8","author":"Y Li","year":"2016","unstructured":"Li Y, Yao J, Han C, Yang J, Chaudhry MT, Wang S, Liu H, Yin Y (2016) Quercetin, inflammation and immunity. Nutrients 8(3):167","journal-title":"Nutrients"},{"key":"1985_CR119","doi-asserted-by":"publisher","first-page":"324","DOI":"10.1007\/s00223-018-0425-1","volume":"103","author":"Z Li","year":"2018","unstructured":"Li Z, Chen C, Zhu X, Li Y, Yu R, Xu W (2018) Glycyrrhizin suppresses RANKL-induced osteoclastogenesis and oxidative stress through inhibiting NF-\u03baB and MAPK and activating AMPK\/Nrf2. Calcif Tissue Int 103:324\u2013337. https:\/\/doi.org\/10.1007\/s00223-018-0425-1","journal-title":"Calcif Tissue Int"},{"key":"1985_CR120","doi-asserted-by":"publisher","first-page":"1577","DOI":"10.1007\/s13402-023-00834-5","volume":"46","author":"J Li","year":"2023","unstructured":"Li J, Xu C, Liu Q (2023) Roles of NRF2 in DNA damage repair. Cell Oncol 46:1577\u20131593. https:\/\/doi.org\/10.1007\/s13402-023-00834-5","journal-title":"Cell Oncol"},{"issue":"3","key":"1985_CR121","first-page":"424","volume":"32","author":"TH Lin","year":"2014","unstructured":"Lin TH, Pajarinen J, Lu L, Nabeshima A, Cordova LA, Yao Z, Goodman SB (2014) Curcumin reduces osteolysis by suppressing inflammatory cytokines and RANKL expression in a mouse model of wear particle-induced osteolysis. J Orthop Res 32(3):424\u2013430","journal-title":"J Orthop Res"},{"key":"1985_CR122","doi-asserted-by":"publisher","first-page":"349","DOI":"10.1007\/s00223-014-9900-5","volume":"95","author":"S Lippross","year":"2014","unstructured":"Lippross S, Beckmann R, Streubesand N, Ayub F, Tohidnezhad M, Campbell G, Kan YW, Horst F, S\u00f6nmez TT, Varoga D, Lichte P (2014a) Nrf2 deficiency impairs fracture healing in mice. Calcif Tissue Int 95:349\u2013361. https:\/\/doi.org\/10.1007\/s00223-014-9900-5","journal-title":"Calcif Tissue Int"},{"key":"1985_CR123","first-page":"102","volume":"63","author":"S Lippross","year":"2014","unstructured":"Lippross S, Beckmann R, Streubesand N, Patzi M, Adams C, Delank KS, Uckert W, Kinne RW, Saalbach A (2014b) Nrf2 regulates osteogenic differentiation and fracture healing via osteocalcin expression. Bone 63:102\u2013109","journal-title":"Bone"},{"key":"1985_CR124","doi-asserted-by":"publisher","first-page":"713","DOI":"10.1016\/j.bbamcr.2008.01.002","volume":"1783","author":"GH Liu","year":"2008","unstructured":"Liu GH, Qu J, Shen X (2008) NF-\u03baB\/p65 antagonizes Nrf2-ARE pathway by depriving CBP from Nrf2 and facilitating recruitment of HDAC3 to MafK. Biochim Biophys Acta Mol Cell Res 1783:713\u2013727. https:\/\/doi.org\/10.1016\/j.bbamcr.2008.01.002","journal-title":"Biochim Biophys Acta Mol Cell Res"},{"key":"1985_CR125","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1038\/nrm3254","volume":"13","author":"F Long","year":"2012","unstructured":"Long F (2012) Building strong bones: molecular regulation of the osteoblast lineage. Nat Rev Mol Cell Biol 13:27\u201338. https:\/\/doi.org\/10.1038\/nrm3254","journal-title":"Nat Rev Mol Cell Biol"},{"key":"1985_CR126","doi-asserted-by":"publisher","first-page":"1256","DOI":"10.1007\/s40242-024-4102-9","volume":"40","author":"Z Luo","year":"2024","unstructured":"Luo Z, Pan L (2024) Study on derivatization and biological activity of natural product daidzein. Chem Res Chin Univ 40:1256\u20131265. https:\/\/doi.org\/10.1007\/s40242-024-4102-9","journal-title":"Chem Res Chin Univ"},{"key":"1985_CR127","doi-asserted-by":"publisher","first-page":"911","DOI":"10.3389\/fphar.2018.00911","volume":"9","author":"JF Luo","year":"2018","unstructured":"Luo JF, Shen XY, Lio CK, Dai Y, Cheng CS, Liu JX, Yao YD, Yu Y, Xie Y, Luo P, Yao XS (2018) Activation of Nrf2\/HO-1 pathway by Nardochinoid C inhibits inflammation and oxidative stress in lipopolysaccharide-stimulated macrophages. Front Pharmacol 9:911. https:\/\/doi.org\/10.3389\/fphar.2018.00911","journal-title":"Front Pharmacol"},{"key":"1985_CR128","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2019.100982","volume":"57","author":"J Luo","year":"2020","unstructured":"Luo J, Mills K, le Cessie S, Noordam R, van Heemst D (2020) Ageing, age-related diseases and oxidative stress: what to do next? Ageing Res Rev 57:100982. https:\/\/doi.org\/10.1016\/j.arr.2019.100982","journal-title":"Ageing Res Rev"},{"key":"1985_CR129","first-page":"5008","volume":"11","author":"Q Ma","year":"2019","unstructured":"Ma Q, Liang M, Tang X, Luo F, Dou C (2019) Vitamin B5 inhibits RANKL induced osteoclastogenesis and ovariectomy induced osteoporosis by scavenging ROS generation. Am J Transl Res 11:5008\u20135018","journal-title":"Am J Transl Res"},{"key":"1985_CR130","doi-asserted-by":"publisher","first-page":"4593","DOI":"10.1039\/C9FO00114J","volume":"10","author":"AM Mahmoud","year":"2019","unstructured":"Mahmoud AM, Hussein OE, Abd El-Twab SM, Hozayen WG (2019) Ferulic acid protects against methotrexate nephrotoxicity via activation of Nrf2\/ARE\/HO-1 signaling and PPAR\u03b3, and suppression of NF-\u03baB\/NLRP3 inflammasome axis. Food Funct 10:4593\u20134607. https:\/\/doi.org\/10.1039\/C9FO00114J","journal-title":"Food Funct"},{"key":"1985_CR131","doi-asserted-by":"publisher","first-page":"266","DOI":"10.1210\/er.2009-0024","volume":"31","author":"SC Manolagas","year":"2010","unstructured":"Manolagas SC (2010) From estrogen-centric to aging and oxidative stress: a revised perspective of the pathogenesis of osteoporosis. Endocr Rev 31:266\u2013300. https:\/\/doi.org\/10.1210\/er.2009-0024","journal-title":"Endocr Rev"},{"key":"1985_CR132","doi-asserted-by":"publisher","first-page":"369","DOI":"10.1016\/j.tem.2010.01.010","volume":"21","author":"SC Manolagas","year":"2010","unstructured":"Manolagas SC, Parfitt AM (2010) What old means to bone. Trends Endocrinol Metab 21:369\u2013374. https:\/\/doi.org\/10.1016\/j.tem.2010.01.010","journal-title":"Trends Endocrinol Metab"},{"issue":"1 Suppl","key":"1985_CR134","first-page":"321","volume":"52","author":"FL Marcu","year":"2011","unstructured":"Marcu FL, Bogdan FL, Mu\u0163iu GA, Laz\u0103r L (2011) The histopathological study of osteoporosis. Rom J Morphol Embryol 52(1 Suppl):321\u2013325","journal-title":"Rom J Morphol Embryol"},{"key":"1985_CR135","doi-asserted-by":"publisher","first-page":"1186","DOI":"10.1111\/febs.16361","volume":"290","author":"H Martini","year":"2023","unstructured":"Martini H, Passos JF (2023) Cellular senescence: all roads lead to mitochondria. FEBS J 290:1186\u20131202. https:\/\/doi.org\/10.1111\/febs.16361","journal-title":"FEBS J"},{"key":"1985_CR136","doi-asserted-by":"publisher","first-page":"323","DOI":"10.1210\/me.2009-0354","volume":"24","author":"M Martin-Millan","year":"2010","unstructured":"Martin-Millan M, Almeida M, Ambrogini E, Han L, Zhao H, Weinstein RS, Jilka RL, O\u2019Brien CA, Manolagas SC (2010) The estrogen receptor-\u03b1 in osteoclasts mediates the protective effects of estrogens on cancellous but not cortical bone. Mol Endocrinol 24:323\u2013334. https:\/\/doi.org\/10.1210\/me.2009-0354","journal-title":"Mol Endocrinol"},{"key":"1985_CR137","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/575482","volume":"2013","author":"D McCormack","year":"2013","unstructured":"McCormack D, McFadden D (2013) A review of pterostilbene antioxidant activity and disease modification. Oxid Med Cell Longev 2013:575482","journal-title":"Oxid Med Cell Longev"},{"issue":"21","key":"1985_CR138","doi-asserted-by":"publisher","first-page":"9926","DOI":"10.1073\/pnas.91.21.9926","volume":"91","author":"P Moi","year":"1994","unstructured":"Moi P, Chan K, Asunis I, Cao A, Kan YW (1994) Isolation of NF-E2-related factor 2 (Nrf2), a NF-E2-like basic leucine zipper transcriptional activator that binds to the tandem NF-E2\/AP1 repeat of the beta-globin locus control region. Proc Natl Acad Sci U S A 91(21):9926\u20139930. https:\/\/doi.org\/10.1073\/pnas.91.21.9926","journal-title":"Proc Natl Acad Sci U S A"},{"key":"1985_CR139","doi-asserted-by":"publisher","first-page":"1613","DOI":"10.1084\/jem.20062525","volume":"204","author":"K Morita","year":"2007","unstructured":"Morita K, Miyamoto T, Fujita N, Kubota Y, Ito K, Takubo K, Miyamoto K, Ninomiya K, Suzuki T, Iwasaki R, Yagi M (2007) Reactive oxygen species induce chondrocyte hypertrophy in endochondral ossification. J Exp Med 204:1613\u20131623. https:\/\/doi.org\/10.1084\/jem.20062525","journal-title":"J Exp Med"},{"key":"1985_CR140","doi-asserted-by":"publisher","first-page":"549","DOI":"10.1016\/j.molmed.2004.09.003","volume":"10","author":"H Motohashi","year":"2004","unstructured":"Motohashi H, Yamamoto M (2004) Nrf2\u2013Keap1 defines a physiologically important stress response mechanism. Trends Mol Med 10:549\u2013557. https:\/\/doi.org\/10.1016\/j.molmed.2004.09.003","journal-title":"Trends Mol Med"},{"key":"1985_CR141","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/S0378-1119(02)00788-6","volume":"294","author":"H Motohashi","year":"2002","unstructured":"Motohashi H, O\u2019Connor T, Katsuoka F, Engel JD, Yamamoto M (2002) Integration and diversity of the regulatory network composed of Maf and CNC families of transcription factors. Gene 294:1\u201312. https:\/\/doi.org\/10.1016\/S0378-1119(02)00788-6","journal-title":"Gene"},{"key":"1985_CR143","doi-asserted-by":"publisher","first-page":"349","DOI":"10.1016\/j.mcna.2021.11.010","volume":"106","author":"P Nona","year":"2022","unstructured":"Nona P, Russell C (2022) Cardio-rheumatology: prevention of cardiovascular disease in inflammatory disorders. Med Clin North Am 106:349\u2013363. https:\/\/doi.org\/10.1016\/j.mcna.2021.11.010","journal-title":"Med Clin North Am"},{"issue":"5","key":"1985_CR146","doi-asserted-by":"publisher","DOI":"10.1111\/acel.13442","volume":"20","author":"M Palmieri","year":"2021","unstructured":"Palmieri M, Almeida M, Nookaew I, Berry R, Patino LC, Zhang X, Boonsanay V, Dahlman-Wright K, Genomics R, Hernandez-Morales A et al (2021) Neutralization of oxidized phospholipids attenuates age-associated bone loss in mice. Aging Cell 20(5):e13442. https:\/\/doi.org\/10.1111\/acel.13442","journal-title":"Aging Cell"},{"issue":"3","key":"1985_CR147","doi-asserted-by":"publisher","DOI":"10.3390\/antiox11030538","volume":"11","author":"H Panda","year":"2022","unstructured":"Panda H, Wen H, Suzuki M, Yamamoto M (2022) Multifaceted roles of the KEAP1\u2013NRF2 system in cancer and inflammatory disease milieu. Antioxidants 11(3):538. https:\/\/doi.org\/10.3390\/antiox11030538","journal-title":"Antioxidants"},{"issue":"3","key":"1985_CR148","doi-asserted-by":"publisher","first-page":"193","DOI":"10.3390\/antiox9030193","volume":"9","author":"E Panieri","year":"2020","unstructured":"Panieri E, Buha A, Telkoparan-Akillilar P, Saso L, Jaruga P, G\u0119gotek A (2020) Potential applications of NRF2 modulators in cancer therapy. Antioxidants (Basel) 9(3):193. https:\/\/doi.org\/10.3390\/antiox9030193","journal-title":"Antioxidants (Basel)"},{"issue":"3","key":"1985_CR149","doi-asserted-by":"publisher","first-page":"694","DOI":"10.1002\/jbmr.1479","volume":"27","author":"S Papapoulos","year":"2012","unstructured":"Papapoulos S, Chapurlat R, Libanati C, Fuentes F, Wang A, Kendler DL, Lewiecki EM, Lippuner K, Minisola S, Roux C, Bone HG (2012) Five years of denosumab exposure in women with postmenopausal osteoporosis: results from the FREEDOM extension trial. J Bone Miner Res 27(3):694\u2013701","journal-title":"J Bone Miner Res"},{"issue":"3","key":"1985_CR150","doi-asserted-by":"publisher","first-page":"393","DOI":"10.1007\/s12031-021-01913-8","volume":"72","author":"M Papasavva","year":"2022","unstructured":"Papasavva M, Vikelis M, Katsarou M-S, Kouvelas D, Vassilopoulos D (2022) Evidence that HFE H63D variant is a potential disease modifier in cluster headache. J Mol Neurosci 72(3):393\u2013400. https:\/\/doi.org\/10.1007\/s12031-021-01913-8","journal-title":"J Mol Neurosci"},{"key":"1985_CR151","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1016\/j.bone.2014.01.025","volume":"63","author":"CK Park","year":"2014","unstructured":"Park CK, Lee Y, Kim KH, Chung HY, Kim BJ, Kim YS (2014) Nrf2 is a novel regulator of bone acquisition. Bone 63:36\u201346. https:\/\/doi.org\/10.1016\/j.bone.2014.01.025","journal-title":"Bone"},{"issue":"18","key":"1985_CR152","doi-asserted-by":"publisher","first-page":"8798","DOI":"10.1021\/acs.chemrev.7b00698","volume":"118","author":"S Parvez","year":"2018","unstructured":"Parvez S, Long MJC, Poganik JR, Aye Y (2018) Redox signaling by reactive electrophiles and oxidants. Chem Rev 118(18):8798\u20138888. https:\/\/doi.org\/10.1021\/acs.chemrev.7b00698","journal-title":"Chem Rev"},{"issue":"3","key":"1985_CR153","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0171161","volume":"12","author":"GG Pellegrini","year":"2017","unstructured":"Pellegrini GG, Cregor M, McAndrews K, Morales CC, McCabe LD, McCabe GP, Peacock M, Burr D, Weaver C, Bellido T (2017) Nrf2 regulates mass accrual and the antioxidant endogenous response in bone differently depending on the sex and age. PLoS ONE 12(3):e0171161. https:\/\/doi.org\/10.1371\/journal.pone.0171161","journal-title":"PLoS ONE"},{"issue":"4","key":"1985_CR154","doi-asserted-by":"publisher","first-page":"327","DOI":"10.1056\/NEJMoa1105351","volume":"365","author":"PE Pergola","year":"2011","unstructured":"Pergola PE, Raskin P, Toto RD, Meyer CJ, Huff JW, Grossman EB, Krauth M, Ruiz S, Audhya P, Warnock DG (2011) Bardoxolone methyl and kidney function in CKD with type 2 diabetes. N Engl J Med 365(4):327\u2013336. https:\/\/doi.org\/10.1056\/NEJMoa1105351","journal-title":"N Engl J Med"},{"issue":"9","key":"1985_CR155","doi-asserted-by":"publisher","first-page":"434","DOI":"10.1016\/S0968-0004(00)01617-0","volume":"25","author":"ND Perkins","year":"2000","unstructured":"Perkins ND (2000) The rel\/NF-\u03baB family: friend and foe. Trends Biochem Sci 25(9):434\u2013440. https:\/\/doi.org\/10.1016\/S0968-0004(00)01617-0","journal-title":"Trends Biochem Sci"},{"key":"1985_CR156","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1111\/j.1749-6632.2000.tb06642.x","volume":"908","author":"C Petropoulou","year":"2000","unstructured":"Petropoulou C, Chondrogianni N, Sim\u00f5es D, Gonos ES (2000) Aging and longevity: a paradigm of complementation between homeostatic mechanisms and genetic control? Ann N Y Acad Sci 908:133\u2013142. https:\/\/doi.org\/10.1111\/j.1749-6632.2000.tb06642.x","journal-title":"Ann N Y Acad Sci"},{"key":"1985_CR158","doi-asserted-by":"publisher","first-page":"8232","DOI":"10.1073\/pnas.82.23.8232","volume":"82","author":"HJ Prochaska","year":"1985","unstructured":"Prochaska HJ, De Long MJ, Talalay P (1985) On the mechanisms of induction of cancer-protective enzymes: a unifying proposal. Proc Natl Acad Sci USA 82:8232\u20138236. https:\/\/doi.org\/10.1073\/pnas.82.23.8232","journal-title":"Proc Natl Acad Sci USA"},{"key":"1985_CR159","doi-asserted-by":"publisher","DOI":"10.1016\/j.mce.2019.110631","volume":"500","author":"L Pronsato","year":"2020","unstructured":"Pronsato L, Milanesi L, Vasconsuelo A (2020) Testosterone induces up-regulation of mitochondrial gene expression in murine C2C12 skeletal muscle cells accompanied by an increase of nuclear respiratory factor-1 and its downstream effectors. Mol Cell Endocrinol 500:110631. https:\/\/doi.org\/10.1016\/j.mce.2019.110631","journal-title":"Mol Cell Endocrinol"},{"issue":"7709","key":"1985_CR160","doi-asserted-by":"publisher","first-page":"301","DOI":"10.1038\/s41586-018-0198-8","volume":"558","author":"X Que","year":"2018","unstructured":"Que X, Hung MY, Yeang C, Gonen A, Prohaska TA, Sun X, Diehl C, M\u00e4\u00e4tt\u00e4 A, Gaddis DE, Bowden K, Pattison J (2018) Oxidized phospholipids are proinflammatory and proatherogenic in hypercholesterolaemic mice. Nature 558(7709):301\u2013306","journal-title":"Nature"},{"issue":"6","key":"1985_CR162","doi-asserted-by":"publisher","first-page":"1121","DOI":"10.1128\/MCB.01204-10","volume":"31","author":"P Rada","year":"2011","unstructured":"Rada P, Rojo AI, Chowdhry S, McMahon M, Hayes JD, Cuadrado A (2011) SCF\/\u03b2-TrCP promotes glycogen synthase kinase 3-dependent degradation of the Nrf2 transcription factor in a Keap1-independent manner. Mol Cell Biol 31(6):1121\u20131133. https:\/\/doi.org\/10.1128\/MCB.01204-10","journal-title":"Mol Cell Biol"},{"issue":"1\u20132","key":"1985_CR164","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s11010-017-3091-0","volume":"437","author":"T Rajakumar","year":"2018","unstructured":"Rajakumar T, Pugalendhi P, Thilagavathi S, Rajagopal S (2018) Allyl isothiocyanate, a potent chemopreventive agent targets AhR\/Nrf2 signaling pathway in chemically induced mammary carcinogenesis. Mol Cell Biochem 437(1\u20132):1\u201312. https:\/\/doi.org\/10.1007\/s11010-017-3091-0","journal-title":"Mol Cell Biochem"},{"issue":"12","key":"1985_CR165","doi-asserted-by":"publisher","first-page":"2298","DOI":"10.1016\/j.freeradbiomed.2012.10.536","volume":"53","author":"T Rana","year":"2012","unstructured":"Rana T, Schultz MA, Freeman ML, Biswas S (2012) Loss of Nrf2 accelerates ionizing radiation-induced bone loss by upregulating RANKL. Free Radic Biol Med 53(12):2298\u20132307. https:\/\/doi.org\/10.1016\/j.freeradbiomed.2012.10.536","journal-title":"Free Radic Biol Med"},{"key":"1985_CR166","first-page":"157","volume":"120","author":"CN Receno","year":"2019","unstructured":"Receno CN, Helmke S, Johnson SA, Vanegas SM, Lin AL, Fox HS, Greenough WT, Wren JD, Flores R, Simske SJ (2019a) Dietary curcumin supplementation improves bone microarchitecture and strength in aged male rats. Bone 120:157\u2013164","journal-title":"Bone"},{"issue":"6","key":"1985_CR167","doi-asserted-by":"publisher","first-page":"772","DOI":"10.1093\/gerona\/gly104","volume":"74","author":"CN Receno","year":"2019","unstructured":"Receno CN, Liang C, Korimilli AS, Galvan V, Choi Y, Donato AJ, Kirwan JP (2019b) Curcumin enhances skeletal muscle strength in aged rats by upregulating Nrf2 expression. J Gerontol A Biol Sci Med Sci 74(6):772\u2013779. https:\/\/doi.org\/10.1093\/gerona\/gly104","journal-title":"J Gerontol A Biol Sci Med Sci"},{"issue":"22","key":"1985_CR168","doi-asserted-by":"publisher","first-page":"5474","DOI":"10.3390\/molecules25225474","volume":"25","author":"S Saha","year":"2020","unstructured":"Saha S, Buttari B, Panieri E, Profumo E, Saso L (2020) An overview of Nrf2 signaling pathway and its role in inflammation. Molecules 25(22):5474. https:\/\/doi.org\/10.3390\/molecules25225474","journal-title":"Molecules"},{"key":"1985_CR169","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2020.101845","volume":"40","author":"C S\u00e1nchez-de-Diego","year":"2021","unstructured":"S\u00e1nchez-de-Diego C, Pedrazza L, Pimenta-Lopes C, Puyet A, Palomo-Irigoyen M, Pajares M et al (2021) Nrf2 function in osteocytes is required for bone homeostasis and drives osteocytic gene expression. Redox Biol 40:101845. https:\/\/doi.org\/10.1016\/j.redox.2020.101845","journal-title":"Redox Biol"},{"key":"1985_CR170","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1016\/j.ejps.2016.09.003","volume":"96","author":"A Santini","year":"2017","unstructured":"Santini A, Tenore GC, Novellino E (2017) Nutraceuticals: a paradigm of proactive medicine. Eur J Pharm Sci 96:53\u201361","journal-title":"Eur J Pharm Sci"},{"issue":"10","key":"1985_CR171","doi-asserted-by":"publisher","first-page":"1618","DOI":"10.1089\/ars.2013.5303","volume":"20","author":"EH Sarsour","year":"2014","unstructured":"Sarsour EH, Kalen AL, Goswami PC (2014) Manganese superoxide dismutase regulates a redox cycle within the cell cycle. Antioxid Redox Signal 20(10):1618\u20131627. https:\/\/doi.org\/10.1089\/ars.2013.5303","journal-title":"Antioxid Redox Signal"},{"issue":"6","key":"1985_CR172","doi-asserted-by":"publisher","first-page":"C734","DOI":"10.1152\/ajpcell.00068.2020","volume":"319","author":"AS Schreurs","year":"2020","unstructured":"Schreurs AS, Torres S, Truong T, Chabosseau P, Smestad J, McKelvey AC, Bennani-Baiti IM, Saucerman JJ, Haigh S, Cortopassi GA, Berridge MV, Meyer JN, Nick JA, Petersen KF, Hill BG, Furdui CM, Furdui RJ (2020) Skeletal tissue regulation by catalase overexpression in mitochondria. Am J Physiol Cell Physiol 319(6):C734\u2013C745. https:\/\/doi.org\/10.1152\/ajpcell.00068.2020","journal-title":"Am J Physiol Cell Physiol"},{"issue":"3","key":"1985_CR173","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1615\/CritRevEukarGeneExpr.v19.i3.40","volume":"19","author":"E Seeman","year":"2009","unstructured":"Seeman E (2009) Bone modeling and remodeling. Crit Rev Eukaryot Gene Expr 19(3):219\u2013233. https:\/\/doi.org\/10.1615\/CritRevEukarGeneExpr.v19.i3.40","journal-title":"Crit Rev Eukaryot Gene Expr"},{"issue":"2","key":"1985_CR174","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0148042","volume":"11","author":"DR Senger","year":"2016","unstructured":"Senger DR, Li D, Jaminet S-C, Cao S (2016) Activation of the Nrf2 cell defense pathway by ancient foods: disease prevention by important molecules and microbes lost from the modern Western diet. PLoS ONE 11(2):e0148042. https:\/\/doi.org\/10.1371\/journal.pone.0148042","journal-title":"PLoS ONE"},{"issue":"1","key":"1985_CR175","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1002\/jbmr.1998","volume":"29","author":"E Shane","year":"2014","unstructured":"Shane E, Burr D, Abrahamsen B, Adler RA, Brown TD, Cheung AM, Cosman F, Curtis JR, Dell R, Dempster DW, Einhorn TA, Genant HK, Geusens P, Klaushofer K, Koval K, Lane JM, McKiernan F, McKinney R, Ng A, Nieves J, O\u2019Keefe R, Papapoulos S, Howe TS, van der Meulen MCH, Weinstein RS (2014) Atypical subtrochanteric and diaphyseal femoral fractures: second report of a task force of the American Society for Bone and Mineral Research. J Bone Miner Res 29(1):1\u201323","journal-title":"J Bone Miner Res"},{"issue":"6","key":"1985_CR176","doi-asserted-by":"publisher","first-page":"512","DOI":"10.3390\/antiox9060512","volume":"9","author":"W Shen","year":"2020","unstructured":"Shen W, Wang Y, Lu Y, Ding Y, Meng X, Yu H, Liu Y, Ji Y, Zhang Y, Li Y (2020a) Isoquercitrin improves skeletal muscle atrophy by modulating oxidative stress, inflammation, and mitochondrial function via Nrf2 pathway. Antioxidants (Basel) 9(6):512. https:\/\/doi.org\/10.3390\/antiox9060512","journal-title":"Antioxidants (Basel)"},{"key":"1985_CR177","doi-asserted-by":"publisher","first-page":"988","DOI":"10.3389\/fphys.2020.00988","volume":"11","author":"Y Shen","year":"2020","unstructured":"Shen Y, Zhang Q, Huang Z, Zhu J, Qiu J, Ma W, Yang X, Ding F, Sun H (2020b) Isoquercitrin delays denervated soleus muscle atrophy by inhibiting oxidative stress and inflammation. Front Physiol 11:988. https:\/\/doi.org\/10.3389\/fphys.2020.00988","journal-title":"Front Physiol"},{"issue":"7","key":"1985_CR178","doi-asserted-by":"publisher","first-page":"363","DOI":"10.1038\/s41580-020-0230-3","volume":"21","author":"H Sies","year":"2020","unstructured":"Sies H, Jones DP (2020) Reactive oxygen species (ROS) as pleiotropic physiological signalling agents. Nat Rev Mol Cell Biol 21(7):363\u2013383. https:\/\/doi.org\/10.1038\/s41580-020-0230-3","journal-title":"Nat Rev Mol Cell Biol"},{"key":"1985_CR179","doi-asserted-by":"publisher","first-page":"715","DOI":"10.1146\/annurev-biochem-061516-045037","volume":"86","author":"H Sies","year":"2017","unstructured":"Sies H, Berndt C, Jones DP (2017) Oxidative stress. Annu Rev Biochem 86:715\u2013748. https:\/\/doi.org\/10.1146\/annurev-biochem-061516-045037","journal-title":"Annu Rev Biochem"},{"issue":"10","key":"1985_CR180","doi-asserted-by":"publisher","first-page":"2521","DOI":"10.3390\/molecules23102521","volume":"23","author":"LM Silva","year":"2018","unstructured":"Silva LM, Alves JS, da Silva Siqueira EM, de Souza Neto MA, Abreu LS, Tavares JF, Porto DL, de Santis FL, Demarque DP, Lopes NP, Arag\u00e3o CF (2018) Isolation and identification of the five novel flavonoids from Genipa americana leaves. Molecules 23(10):2521. https:\/\/doi.org\/10.3390\/molecules23102521","journal-title":"Molecules"},{"issue":"5","key":"1985_CR181","doi-asserted-by":"publisher","first-page":"1165","DOI":"10.1073\/pnas.1522872114","volume":"114","author":"G Skibinski","year":"2017","unstructured":"Skibinski G, Hwang V, Ando DM, Daub A, Lee AK, Ravisankar A, Modan S, Finucane MM, Shaby BA, Finkbeiner S (2017) Nrf2 mitigates LRRK2- and \u03b1-synuclein\u2013induced neurodegeneration by modulating proteostasis. Proc Natl Acad Sci U S A 114(5):1165\u20131170. https:\/\/doi.org\/10.1073\/pnas.1522872114","journal-title":"Proc Natl Acad Sci U S A"},{"key":"1985_CR182","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1016\/j.freeradbiomed.2015.07.006","volume":"89","author":"X Song","year":"2015","unstructured":"Song X, Yin S, Huo Y, Liang M, Fan L, Ye M, Hu H (2015) Glycycoumarin ameliorates alcohol-induced hepatotoxicity via activation of Nrf2 and autophagy. Free Radic Biol Med 89:135\u2013146. https:\/\/doi.org\/10.1016\/j.freeradbiomed.2015.07.006","journal-title":"Free Radic Biol Med"},{"issue":"8","key":"1985_CR183","doi-asserted-by":"publisher","first-page":"564","DOI":"10.1038\/nrc3278","volume":"12","author":"MB Sporn","year":"2012","unstructured":"Sporn MB, Liby KT (2012) NRF2 and cancer: the good, the bad and the importance of context. Nat Rev Cancer 12(8):564\u2013571. https:\/\/doi.org\/10.1038\/nrc3278","journal-title":"Nat Rev Cancer"},{"key":"1985_CR184","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1007\/s11657-011-0060-1","volume":"6","author":"O Str\u00f6m","year":"2011","unstructured":"Str\u00f6m O, Borgstr\u00f6m F, Kanis JA, Compston J, Cooper C, McCloskey EV, J\u00f6nsson B (2011) Osteoporosis: burden, health care provision and opportunities in the EU. Arch Osteoporos 6:59\u2013155. https:\/\/doi.org\/10.1007\/s11657-011-0060-1","journal-title":"Arch Osteoporos"},{"key":"1985_CR186","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1186\/s12929-015-0106-3","volume":"22","author":"YX Sun","year":"2015","unstructured":"Sun YX, Xu AH, Yang Y, Li J (2015a) Role of Nrf2 in bone metabolism. J Biomed Sci 22:101. https:\/\/doi.org\/10.1186\/s12929-015-0106-3","journal-title":"J Biomed Sci"},{"issue":"6","key":"1985_CR187","first-page":"1206","volume":"230","author":"Y Sun","year":"2015","unstructured":"Sun Y, Xun K, Wang C, Zhao H, Bi H, Chen X (2015b) Nrf2 signaling and its contribution to protective effects in bone marrow-derived mesenchymal stem cells. J Cell Physiol 230(6):1206\u20131217","journal-title":"J Cell Physiol"},{"key":"1985_CR188","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1186\/s12929-015-0212-5","volume":"22","author":"YX Sun","year":"2015","unstructured":"Sun YX, Xu AH, Yang Y, Li J (2015c) Role of Nrf2 in bone metabolism. J Biomed Sci 22:101. https:\/\/doi.org\/10.1186\/s12929-015-0212-5","journal-title":"J Biomed Sci"},{"issue":"7","key":"1985_CR189","doi-asserted-by":"publisher","first-page":"439","DOI":"10.1302\/2046-3758.117.BJR-2021-0355.R1","volume":"11","author":"Q Sun","year":"2022","unstructured":"Sun Q, Li G, Liu D, Xie W, Xiao W, Li Y, Cai M (2022) Peripheral nerves in the tibial subchondral bone: the role of pain and homeostasis in osteoarthritis. Bone Joint Res 11(7):439\u2013452. https:\/\/doi.org\/10.1302\/2046-3758.117.BJR-2021-0355.R1","journal-title":"Bone Joint Res"},{"key":"1985_CR192","doi-asserted-by":"publisher","first-page":"8261","DOI":"10.1073\/pnas.85.21.8261","volume":"85","author":"P Talalay","year":"1988","unstructured":"Talalay P, De Long MJ, Prochaska HJ (1988) Identification of a common chemical signal regulating the induction of enzymes that protect against chemical carcinogenesis. Proc Natl Acad Sci U S A 85:8261\u20138265. https:\/\/doi.org\/10.1073\/pnas.85.21.8261","journal-title":"Proc Natl Acad Sci U S A"},{"key":"1985_CR194","doi-asserted-by":"publisher","first-page":"1162","DOI":"10.3389\/fphar.2018.01162","volume":"9","author":"BL Tan","year":"2018","unstructured":"Tan BL, Norhaizan ME, Liew W-P-P, Sulaiman Rahman H (2018) Antioxidant and oxidative stress: a mutual interplay in age-related diseases. Front Pharmacol 9:1162. https:\/\/doi.org\/10.3389\/fphar.2018.01162","journal-title":"Front Pharmacol"},{"issue":"10","key":"1985_CR195","doi-asserted-by":"publisher","first-page":"3926","DOI":"10.1039\/C7FO00822H","volume":"8","author":"Q Tang","year":"2017","unstructured":"Tang Q, Feng Z, Tong M, Xu J, Zheng G, Shen L, Shang P, Zhang Y, Liu H (2017) Piceatannol inhibits the IL-1\u03b2-induced inflammatory response in human osteoarthritic chondrocytes and ameliorates osteoarthritis in mice by activating Nrf2. Food Funct 8(10):3926\u20133937. https:\/\/doi.org\/10.1039\/C7FO00822H","journal-title":"Food Funct"},{"issue":"5","key":"1985_CR196","doi-asserted-by":"publisher","first-page":"1417","DOI":"10.3390\/molecules26051417","volume":"26","author":"P Telkoparan-Akillilar","year":"2021","unstructured":"Telkoparan-Akillilar P, Panieri E, Cevik D, Tuncer E, Genc S, Saso L (2021) Therapeutic targeting of the NRF2 signaling pathway in cancer. Molecules 26(5):1417. https:\/\/doi.org\/10.3390\/molecules26051417","journal-title":"Molecules"},{"issue":"4","key":"1985_CR198","doi-asserted-by":"publisher","first-page":"984","DOI":"10.1172\/JCI25790","volume":"116","author":"RK Thimmulappa","year":"2006","unstructured":"Thimmulappa RK, Lee H, Rangasamy T, Reddy SP, Yamamoto M, Kensler TW, Biswal S (2006) Nrf2 is a critical regulator of the innate immune response and survival during experimental sepsis. J Clin Invest 116(4):984\u2013995. https:\/\/doi.org\/10.1172\/JCI25790","journal-title":"J Clin Invest"},{"issue":"4","key":"1985_CR199","doi-asserted-by":"publisher","first-page":"311","DOI":"10.1038\/nsb0497-311","volume":"4","author":"L Tong","year":"1997","unstructured":"Tong L, Pav S, White DM, Xu S, Swenson L, Rogers S, Crane KM, Cywin CL, Brown ML, Pargellis CA (1997) A highly specific inhibitor of human p38 MAP kinase binds in the ATP pocket. Nat Struct Biol 4(4):311\u2013316. https:\/\/doi.org\/10.1038\/nsb0497-311","journal-title":"Nat Struct Biol"},{"key":"1985_CR200","unstructured":"U.S. Food and Drug Administration (FDA) (2023) Dietary Supplements. Available from: https:\/\/www.fda.gov\/food\/dietary-supplements"},{"key":"1985_CR201","unstructured":"U.S. National Institutes of Health, Office of Dietary Supplements (2025) Dietary Supplement Ingredient Database (DSID). [Internet]. [cited 2025 May 30]. Available from: https:\/\/ods.od.nih.gov"},{"issue":"3","key":"1985_CR202","doi-asserted-by":"publisher","first-page":"560","DOI":"10.1002\/jbmr.3014","volume":"32","author":"S Ucer","year":"2017","unstructured":"Ucer S, Iyer S, Kim HN, Han L, Rutlen C, Allison K, Thostenson JD, de Cabo R, Jilka RL, O\u2019Brien CA, Almeida M, Manolagas SC (2017) The effects of aging and sex steroid deficiency on the murine skeleton are independent and mechanistically distinct. J Bone Miner Res 32(3):560\u2013574. https:\/\/doi.org\/10.1002\/jbmr.3014","journal-title":"J Bone Miner Res"},{"issue":"1","key":"1985_CR203","doi-asserted-by":"publisher","first-page":"H18","DOI":"10.1152\/ajpheart.00260.2010","volume":"299","author":"Z Ungvari","year":"2010","unstructured":"Ungvari Z, Bagi Z, Feher A, Recchia FA, Sonntag WE, Pearson K, de Cabo R, Csiszar A (2010) Resveratrol confers endothelial protection via activation of the antioxidant transcription factor Nrf2. Am J Physiol Heart Circ Physiol 299(1):H18\u2013H24. https:\/\/doi.org\/10.1152\/ajpheart.00260.2010","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"1985_CR204","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1007\/s00223-006-0019-1","volume":"79","author":"TP van Staa","year":"2006","unstructured":"van Staa TP (2006) The pathogenesis, epidemiology and management of glucocorticoid-induced osteoporosis. Calcif Tissue Int 79:129\u2013137. https:\/\/doi.org\/10.1007\/s00223-006-0019-1","journal-title":"Calcif Tissue Int"},{"key":"1985_CR205","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1007\/978-1-4939-8931-7_3","volume-title":"Cellular senescence: methods and protocols","author":"S Victorelli","year":"2019","unstructured":"Victorelli S, Passos JF (2019) Reactive oxygen species detection in senescent cells. In: Demaria M (ed) Cellular senescence: methods and protocols. Springer, New York, pp 21\u201329"},{"issue":"11","key":"1985_CR206","doi-asserted-by":"publisher","first-page":"1649","DOI":"10.1089\/ars.2010.3216","volume":"13","author":"N Wakabayashi","year":"2010","unstructured":"Wakabayashi N, Slocum SL, Skoko JJ, Shin S, Kensler TW (2010) When NRF2 talks, who\u2019s listening? Antioxid Redox Signal 13(11):1649\u20131663. https:\/\/doi.org\/10.1089\/ars.2010.3216","journal-title":"Antioxid Redox Signal"},{"key":"1985_CR207","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1111\/j.1749-6632.2010.05842.x","volume":"1215","author":"T Walle","year":"2011","unstructured":"Walle T (2011) Bioavailability of resveratrol. Ann N Y Acad Sci 1215:9\u201315","journal-title":"Ann N Y Acad Sci"},{"issue":"4","key":"1985_CR209","doi-asserted-by":"publisher","first-page":"441","DOI":"10.1002\/biof.1599","volume":"46","author":"G Wang","year":"2020","unstructured":"Wang G, Xie X, Yuan L, Li L, Wang X, Liu Z, Xu W (2020) Resveratrol ameliorates rheumatoid arthritis via activation of SIRT1-Nrf2 signaling pathway. BioFactors 46(4):441\u2013453. https:\/\/doi.org\/10.1002\/biof.1599","journal-title":"BioFactors"},{"key":"1985_CR210","doi-asserted-by":"publisher","first-page":"387","DOI":"10.1186\/s13018-023-03874-7","volume":"18","author":"F Wang","year":"2023","unstructured":"Wang F, Sun R, Zhang S-D, Wu X-T (2023) Comparison of acute single versus multiple osteoporotic vertebral compression fractures in radiographic characteristic and bone fragility. J Orthop Surg Res 18:387. https:\/\/doi.org\/10.1186\/s13018-023-03874-7","journal-title":"J Orthop Surg Res"},{"issue":"11","key":"1985_CR211","doi-asserted-by":"publisher","first-page":"1763","DOI":"10.2215\/CJN.02400222","volume":"17","author":"BA Warady","year":"2022","unstructured":"Warady BA, Pergola PE, Agarwal R, Kaskel F, Mitsnefes M, Wheeler D, Kopp JB, Brunner HI, Hebert D, Smoyer WE, Song P, Williams NM, Nester CM, Furth S, Srivastava T, Massengill SF, Adler SG, Kaplan BS, Benador D, Kupferman JC, Harshman LA, Somers MJ, Wenderfer SE, Anwar F, Thompson J, Ma L, Wallace DP (2022) Effects of Bardoxolone methyl in Alport syndrome. Clin J Am Soc Nephrol 17(11):1763. https:\/\/doi.org\/10.2215\/CJN.02400222","journal-title":"Clin J Am Soc Nephrol"},{"issue":"7","key":"1985_CR212","doi-asserted-by":"publisher","first-page":"541","DOI":"10.1089\/ars.2017.7425","volume":"29","author":"CC Winterbourn","year":"2018","unstructured":"Winterbourn CC (2018) Biological production, detection, and fate of hydrogen peroxide. Antioxid Redox Signal 29(7):541\u2013551. https:\/\/doi.org\/10.1089\/ars.2017.7425","journal-title":"Antioxid Redox Signal"},{"issue":"3","key":"1985_CR213","doi-asserted-by":"publisher","first-page":"541","DOI":"10.1007\/s00198-018-04828-0","volume":"30","author":"RMY Wong","year":"2019","unstructured":"Wong RMY, Wong H, Zhang N, Woo J, Leung JCS (2019) The relationship between sarcopenia and fragility fracture\u2014a systematic review. Osteoporos Int 30(3):541\u2013553. https:\/\/doi.org\/10.1007\/s00198-018-04828-0","journal-title":"Osteoporos Int"},{"issue":"6","key":"1985_CR214","first-page":"1134","volume":"35","author":"RHX Wong","year":"2020","unstructured":"Wong RHX, Thaung Zaw JJ, Howe PRC, Coates AM, Buckley JD, Murphy KJ (2020) Regular supplementation with resveratrol improves bone mineral density in postmenopausal women: a randomized, double-blind, placebo-controlled trial. J Bone Miner Res 35(6):1134\u20131143","journal-title":"J Bone Miner Res"},{"issue":"4","key":"1985_CR215","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0059843","volume":"8","author":"J Wu","year":"2013","unstructured":"Wu J, Li Q, Wang X, Lin L, Wang Q, Fu X, Zhang T, Zhang Q (2013) Neuroprotection by curcumin in ischemic brain injury involves the Akt\/Nrf2 pathway. PLoS ONE 8(4):e59843. https:\/\/doi.org\/10.1371\/journal.pone.0059843","journal-title":"PLoS ONE"},{"issue":"2","key":"1985_CR217","doi-asserted-by":"publisher","first-page":"169","DOI":"10.2174\/138955711794519546","volume":"11","author":"ZP Xiao","year":"2011","unstructured":"Xiao ZP, Peng ZY, Peng MJ, Yan M, He J, Ouyang YZ (2011) Flavonoids health benefits and their molecular mechanism. Mini Rev Med Chem 11(2):169\u2013177. https:\/\/doi.org\/10.2174\/138955711794519546","journal-title":"Mini Rev Med Chem"},{"issue":"9","key":"1985_CR218","doi-asserted-by":"publisher","first-page":"2758","DOI":"10.1128\/MCB.01704-07","volume":"28","author":"T Yamamoto","year":"2008","unstructured":"Yamamoto T, Suzuki T, Kobayashi A, Wakabayashi J, Maher J, Motohashi H, Yamamoto M (2008) Physiological significance of reactive cysteine residues of Keap1 in determining Nrf2 activity. Mol Cell Biol 28(9):2758\u20132770. https:\/\/doi.org\/10.1128\/MCB.01704-07","journal-title":"Mol Cell Biol"},{"issue":"3","key":"1985_CR219","doi-asserted-by":"publisher","first-page":"1169","DOI":"10.1152\/physrev.00023.2017","volume":"98","author":"M Yamamoto","year":"2018","unstructured":"Yamamoto M, Kensler TW, Motohashi H (2018) The KEAP1-NRF2 system: a thiol-based sensor-effector apparatus for maintaining redox homeostasis. Physiol Rev 98(3):1169\u20131203. https:\/\/doi.org\/10.1152\/physrev.00023.2017","journal-title":"Physiol Rev"},{"issue":"2","key":"1985_CR220","doi-asserted-by":"publisher","first-page":"399","DOI":"10.1042\/BJ20050795","volume":"391","author":"H Yang","year":"2005","unstructured":"Yang H, Magilnick N, Ou X, Lu SC (2005) Tumour necrosis factor \u03b1 induces co-ordinated activation of rat GSH synthetic enzymes via nuclear factor \u03baB and activator protein-1. Biochem J 391(2):399\u2013408. https:\/\/doi.org\/10.1042\/BJ20050795","journal-title":"Biochem J"},{"issue":"22","key":"1985_CR221","doi-asserted-by":"publisher","first-page":"6614","DOI":"10.1016\/j.bmc.2017.10.044","volume":"25","author":"Z Yang","year":"2017","unstructured":"Yang Z, Zhu M, Li D, Zhang Z, Tian S, Zhang X, Chen X, Wu L, Li J, Xue Y (2017) N-Me-trichodermamide B isolated from Penicillium janthinellum, with antioxidant properties through Nrf2-mediated signaling pathway. Bioorg Med Chem 25(22):6614\u20136622. https:\/\/doi.org\/10.1016\/j.bmc.2017.10.044","journal-title":"Bioorg Med Chem"},{"key":"1985_CR222","doi-asserted-by":"publisher","DOI":"10.1038\/cddis.2014.221","volume":"5","author":"J Yao","year":"2014","unstructured":"Yao J, Zhao L, Zhao Q, Zhao Y, Sun Y, Zhang Y, Zhang X, Zhao L, Wang Z, Wang Y (2014) NF-\u03baB and Nrf2 signaling pathways contribute to wogonin-mediated inhibition of inflammation-associated colorectal carcinogenesis. Cell Death Dis 5:e1283. https:\/\/doi.org\/10.1038\/cddis.2014.221","journal-title":"Cell Death Dis"},{"issue":"18","key":"1985_CR223","doi-asserted-by":"publisher","first-page":"6723","DOI":"10.3390\/ijms21186723","volume":"21","author":"CH Yen","year":"2020","unstructured":"Yen CH, Hsu CM, Hsiao SY, Hsiao HH (2020) Pathogenic mechanisms of myeloma bone disease and possible roles for NRF2. Int J Mol Sci 21(18):6723. https:\/\/doi.org\/10.3390\/ijms21186723","journal-title":"Int J Mol Sci"},{"issue":"47","key":"1985_CR224","doi-asserted-by":"publisher","first-page":"13120","DOI":"10.1021\/bi7014822","volume":"46","author":"S Yi","year":"2007","unstructured":"Yi S, Boys BL, Brickenden A, Soares IN, Toshchakov VY, Forman-Kay JD, Vogel HJ (2007) Effects of zinc binding on the structure and dynamics of the intrinsically disordered protein prothymosin \u03b1: evidence for metalation as an entropic switch. Biochemistry 46(47):13120\u201313130. https:\/\/doi.org\/10.1021\/bi7014822","journal-title":"Biochemistry"},{"key":"1985_CR225","volume":"127","author":"H Yin","year":"2020","unstructured":"Yin H, Wang S, Zhang Y, Yang X, Feng Y, Du J, Zhao L (2020a) Sulforaphane ameliorates ovariectomy-induced osteoporosis by activating Nrf2 signaling in mice. Biomed Pharmacother 127:110152","journal-title":"Biomed Pharmacother"},{"issue":"1","key":"1985_CR226","doi-asserted-by":"publisher","first-page":"348","DOI":"10.1038\/s41598-019-57185-1","volume":"10","author":"Y Yin","year":"2020","unstructured":"Yin Y, Corry KA, Loughran JP, Li J (2020b) Moderate Nrf2 activation by genetic disruption of Keap1 has sex-specific effects on bone mass in mice. Sci Rep 10(1):348. https:\/\/doi.org\/10.1038\/s41598-019-57185-1","journal-title":"Sci Rep"},{"issue":"5","key":"1985_CR227","doi-asserted-by":"publisher","first-page":"386","DOI":"10.1111\/gtc.12579","volume":"23","author":"E Yoshida","year":"2018","unstructured":"Yoshida E, Suzuki T, Morita M, Hirano H, Motohashi H, Yamamoto M (2018) Hyperactivation of Nrf2 leads to hypoplasia of bone in vivo. Genes Cells 23(5):386\u2013392. https:\/\/doi.org\/10.1111\/gtc.12579","journal-title":"Genes Cells"},{"key":"1985_CR228","doi-asserted-by":"publisher","DOI":"10.1155\/2021\/6635460","volume":"2021","author":"C Yu","year":"2021","unstructured":"Yu C, Xiao JH (2021) The Keap1-Nrf2 system: a mediator between oxidative stress and aging. Oxid Med Cell Longev 2021:6635460. https:\/\/doi.org\/10.1155\/2021\/6635460","journal-title":"Oxid Med Cell Longev"},{"issue":"5","key":"1985_CR229","doi-asserted-by":"publisher","first-page":"883","DOI":"10.1016\/j.cellsig.2011.01.014","volume":"23","author":"M Yu","year":"2011","unstructured":"Yu M, Li H, Liu Q, Liu F, Tang L, Li C, Wu Y, Wang X, Sun X, Liu Z (2011) Nuclear factor p65 interacts with Keap1 to repress the Nrf2-ARE pathway. Cell Signal 23(5):883\u2013892. https:\/\/doi.org\/10.1016\/j.cellsig.2011.01.014","journal-title":"Cell Signal"},{"key":"1985_CR232","first-page":"293","volume":"207","author":"D Zhang","year":"2018","unstructured":"Zhang D, Hu X, Peng X, Zhang J, Wang Y, Liu L (2018) Quercetin attenuates glucocorticoid-induced osteoporosis in rats via activation of Nrf2 signaling pathway. Life Sci 207:293\u2013301","journal-title":"Life Sci"},{"key":"1985_CR233","doi-asserted-by":"publisher","first-page":"1064","DOI":"10.1093\/toxres\/tfae064","volume":"13","author":"D Zhang","year":"2024","unstructured":"Zhang D, Li J, Li X, Li H, Li C, Yuan S, Chen W, Jiang Y, Yang P (2024) Anti-osteoporosis activity of casticin in ovariectomized rats. Toxicol Res 13:1064. https:\/\/doi.org\/10.1093\/toxres\/tfae064","journal-title":"Toxicol Res"},{"issue":"7","key":"1985_CR235","doi-asserted-by":"publisher","first-page":"4214","DOI":"10.3390\/md12074214","volume":"12","author":"J Zheng","year":"2014","unstructured":"Zheng J, Piao MJ, Kim KC, Kang KA, Wang ZH, Lee KH, Kim BJ, Chae S, Hyun JW (2014) Fucoxanthin enhances the level of reduced glutathione via the Nrf2-mediated pathway in human keratinocytes. Mar Drugs 12(7):4214\u20134230. https:\/\/doi.org\/10.3390\/md12074214","journal-title":"Mar Drugs"},{"issue":"7\u20138","key":"1985_CR236","first-page":"753","volume":"32","author":"Y Zhou","year":"2016","unstructured":"Zhou Y, Zheng J, Li Y, Xu DP, Li S, Chen YM, Li HB (2016) Natural polyphenols for prevention and treatment of bone-related diseases. Nutrition 32(7\u20138):753\u2013765","journal-title":"Nutrition"},{"issue":"2","key":"1985_CR237","doi-asserted-by":"publisher","first-page":"577","DOI":"10.1016\/j.apsb.2022.07.019","volume":"13","author":"Y Zhou","year":"2023","unstructured":"Zhou Y, Tang J, Lan J, Lin C, Huang W, Liu X, Luo H, Li X, Chen J, Liu P, Liu H (2023) Honokiol alleviated neurodegeneration by reducing oxidative stress and improving mitochondrial function in mutant SOD1 cellular and mouse models of amyotrophic lateral sclerosis. Acta Pharm Sin B 13(2):577\u2013597. https:\/\/doi.org\/10.1016\/j.apsb.2022.07.019","journal-title":"Acta Pharm Sin B"},{"key":"1985_CR239","doi-asserted-by":"publisher","DOI":"10.1038\/cddis.2014.190","volume":"5","author":"X Zou","year":"2014","unstructured":"Zou X, Gao J, Zheng Y, Wang J, Gao Q, Tang W, Zhu J, Zhou X (2014) Zeaxanthin induces Nrf2-mediated phase II enzymes in protection of cell death. Cell Death Dis 5:e1218. https:\/\/doi.org\/10.1038\/cddis.2014.190","journal-title":"Cell Death Dis"}],"container-title":["Inflammopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10787-025-01985-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10787-025-01985-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10787-025-01985-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,17]],"date-time":"2025-11-17T23:05:02Z","timestamp":1763420702000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10787-025-01985-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10,11]]},"references-count":203,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2025,11]]}},"alternative-id":["1985"],"URL":"https:\/\/doi.org\/10.1007\/s10787-025-01985-7","relation":{},"ISSN":["0925-4692","1568-5608"],"issn-type":[{"value":"0925-4692","type":"print"},{"value":"1568-5608","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,10,11]]},"assertion":[{"value":"28 April 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 September 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 October 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"All authors have consented to publish this manuscript.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no potential conflict of interest.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}