{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T17:18:30Z","timestamp":1793121510933,"version":"4.5.0"},"reference-count":183,"publisher":"Springer Science and Business Media LLC","issue":"11","license":[{"start":{"date-parts":[[2025,10,2]],"date-time":"2025-10-02T00:00:00Z","timestamp":1759363200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,10,2]],"date-time":"2025-10-02T00:00:00Z","timestamp":1759363200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Inflammopharmacol"],"published-print":{"date-parts":[[2025,11]]},"DOI":"10.1007\/s10787-025-01991-9","type":"journal-article","created":{"date-parts":[[2025,10,2]],"date-time":"2025-10-02T11:33:02Z","timestamp":1759404782000},"page":"6485-6505","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Neurodegeneration and aging: pathophysiology, diagnosis, and therapeutic targets"],"prefix":"10.1007","volume":"33","author":[{"given":"Abhay","family":"Thakur","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rahul","family":"Sharma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-6352-0535","authenticated-orcid":false,"given":"Rohit","family":"Sharma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anjana","family":"Devi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,10,2]]},"reference":[{"issue":"7","key":"1991_CR1","doi-asserted-by":"publisher","first-page":"505","DOI":"10.1016\/S1474-4422(17)30115-1","volume":"16","author":"K Abe","year":"2017","unstructured":"Abe K, Aoki M, Tsuji S, Itoyama Y, Sobue G, Togo M, Hamada C, Tanaka M, Akimoto M, Nakamura K (2017) Safety and efficacy of edaravone in well defined patients with amyotrophic lateral sclerosis: a randomised, double-blind, placebo-controlled trial. Lancet Neurol 16(7):505\u2013512","journal-title":"Lancet Neurol"},{"issue":"4","key":"1991_CR2","doi-asserted-by":"publisher","first-page":"1592","DOI":"10.18632\/aging.203925","volume":"14","author":"J Aguado","year":"2022","unstructured":"Aguado J, Wolvetang EJ (2022) Exploring aging interventions in human brain organoids. Aging (Albany NY) 14(4):1592\u20131593. https:\/\/doi.org\/10.18632\/aging.203925","journal-title":"Aging (Albany NY)"},{"key":"1991_CR3","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1016\/j.pneurobio.2018.10.001","volume":"171","author":"F Alasmari","year":"2018","unstructured":"Alasmari F, Goodwani S, McCullumsmith RE, Sari Y (2018) Role of glutamatergic system and mesocorticolimbic circuits in alcohol dependence. Prog Neurobiol 171:32\u201349. https:\/\/doi.org\/10.1016\/j.pneurobio.2018.10.001","journal-title":"Prog Neurobiol"},{"issue":"1","key":"1991_CR4","doi-asserted-by":"publisher","DOI":"10.1186\/alzrt160","volume":"5","author":"A Atri","year":"2013","unstructured":"Atri A, Molinuevo JL, Lemming O, Wirth Y, Pulte I, Wilkinson D (2013) Memantine in patients with Alzheimer\u2019s disease receiving donepezil: new analyses of efficacy and safety for combination therapy. Alzheimers Res Ther 5(1):6. https:\/\/doi.org\/10.1186\/alzrt160","journal-title":"Alzheimers Res Ther"},{"issue":"10004","key":"1991_CR5","doi-asserted-by":"publisher","first-page":"1672","DOI":"10.1016\/S0140-6736(15)00461-4","volume":"386","author":"J Bang","year":"2015","unstructured":"Bang J, Spina S, Miller BL (2015) Non-Alzheimer\u2019s dementia 1: frontotemporal dementia. Lancet (London, England) 386(10004):1672","journal-title":"Lancet (London, England)"},{"issue":"1","key":"1991_CR6","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1016\/j.neurobiolaging.2003.03.001","volume":"25","author":"G Bartzokis","year":"2004","unstructured":"Bartzokis G (2004) Age-related myelin breakdown: a developmental model of cognitive decline and Alzheimer\u2019s disease. Neurobiol Aging 25(1):5\u201318. https:\/\/doi.org\/10.1016\/j.neurobiolaging.2003.03.001","journal-title":"Neurobiol Aging"},{"issue":"5","key":"1991_CR7","doi-asserted-by":"publisher","first-page":"515","DOI":"10.1038\/ng1769","volume":"38","author":"A Bender","year":"2006","unstructured":"Bender A, Krishnan KJ, Morris CM, Taylor GA, Reeve AK, Perry RH, Jaros E, Hersheson JS, Betts J, Klopstock T (2006a) High levels of mitochondrial DNA deletions in substantia nigra neurons in aging and Parkinson disease. Nat Genet 38(5):515\u2013517","journal-title":"Nat Genet"},{"issue":"5","key":"1991_CR8","doi-asserted-by":"publisher","first-page":"515","DOI":"10.1038\/ng1769","volume":"38","author":"A Bender","year":"2006","unstructured":"Bender A, Krishnan KJ, Morris CM, Taylor GA, Reeve AK, Perry RH, Jaros E, Hersheson JS, Betts J, Klopstock T, Taylor RW, Turnbull DM (2006b) High levels of mitochondrial DNA deletions in substantia nigra neurons in aging and Parkinson disease. Nat Genet 38(5):515\u2013517. https:\/\/doi.org\/10.1038\/ng1769","journal-title":"Nat Genet"},{"issue":"2","key":"1991_CR9","doi-asserted-by":"publisher","first-page":"297","DOI":"10.1042\/BST20110766","volume":"40","author":"MJ Berridge","year":"2012","unstructured":"Berridge MJ (2012) Calcium signalling remodelling and disease. Biochem Soc Trans 40(2):297\u2013309","journal-title":"Biochem Soc Trans"},{"key":"1991_CR10","unstructured":"Birks JS, Chong LY, Grimley Evans J, Dementia C, Group CI (1996) Rivastigmine for Alzheimer's disease. Cochrane Database Syst Rev 2020(3)"},{"issue":"2","key":"1991_CR11","doi-asserted-by":"publisher","first-page":"413","DOI":"10.3233\/JAD-2009-1177","volume":"18","author":"K Blennow","year":"2009","unstructured":"Blennow K, Zetterberg H (2009) Cerebrospinal fluid biomarkers for Alzheimer\u2019s disease. J Alzheimers Dis 18(2):413\u2013417","journal-title":"J Alzheimers Dis"},{"issue":"6","key":"1991_CR12","doi-asserted-by":"publisher","first-page":"643","DOI":"10.1111\/joim.12816","volume":"284","author":"K Blennow","year":"2018","unstructured":"Blennow K, Zetterberg H (2018) Biomarkers for Alzheimer\u2019s disease: current status and prospects for the future. J Intern Med 284(6):643\u2013663. https:\/\/doi.org\/10.1111\/joim.12816","journal-title":"J Intern Med"},{"issue":"10291","key":"1991_CR13","doi-asserted-by":"publisher","first-page":"2284","DOI":"10.1016\/S0140-6736(21)00218-X","volume":"397","author":"BR Bloem","year":"2021","unstructured":"Bloem BR, Okun MS, Klein C (2021) Parkinson\u2019s disease. Lancet 397(10291):2284\u20132303","journal-title":"Lancet"},{"issue":"19","key":"1991_CR14","doi-asserted-by":"publisher","first-page":"6726","DOI":"10.1523\/JNEUROSCI.0759-10.2010","volume":"30","author":"EB Bloss","year":"2010","unstructured":"Bloss EB, Janssen WG, McEwen BS, Morrison JH (2010) Interactive effects of stress and aging on structural plasticity in the prefrontal cortex. J Neurosci 30(19):6726\u20136731. https:\/\/doi.org\/10.1523\/JNEUROSCI.0759-10.2010","journal-title":"J Neurosci"},{"key":"1991_CR15","unstructured":"Booij J, Habraken JB, Bergmans P, Tissingh G, Winogrodzka A, Wolters EC, Janssen AG, Stoof JC, van Royen EA (1998) Imaging of dopamine transporters with iodine-123-FP-CIT SPECT in healthy controls and patients with Parkinson's disease. J Nucl Med 39(11):1879\u20131884. https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/9829575"},{"issue":"5","key":"1991_CR16","first-page":"281","volume":"15","author":"N Bray","year":"2014","unstructured":"Bray N (2014) \u2019Seeing\u2019bodies via sounds. Nat Rev Neurosci 15(5):281\u2013281","journal-title":"Nat Rev Neurosci"},{"issue":"9","key":"1991_CR17","doi-asserted-by":"publisher","first-page":"540","DOI":"10.1038\/s41582-019-0231-z","volume":"15","author":"F Bright","year":"2019","unstructured":"Bright F, Werry EL, Dobson-Stone C, Piguet O, Ittner LM, Halliday GM, Hodges JR, Kiernan MC, Loy CT, Kassiou M, Kril JJ (2019) Neuroinflammation in frontotemporal dementia. Nat Rev Neurol 15(9):540\u2013555. https:\/\/doi.org\/10.1038\/s41582-019-0231-z","journal-title":"Nat Rev Neurol"},{"key":"1991_CR18","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/1750-1326-9-53","volume":"9","author":"A Brinkmalm","year":"2014","unstructured":"Brinkmalm A, Brinkmalm G, Honer WG, Fr\u00f6lich L, Hausner L, Minthon L, Hansson O, Wallin A, Zetterberg H, Blennow K (2014) SNAP-25 is a promising novel cerebrospinal fluid biomarker for synapse degeneration in Alzheimer\u2019s disease. Mol Neurodegener 9:1\u201313","journal-title":"Mol Neurodegener"},{"issue":"1","key":"1991_CR19","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1038\/nrn1809","volume":"7","author":"SN Burke","year":"2006","unstructured":"Burke SN, Barnes CA (2006) Neural plasticity in the ageing brain. Nat Rev Neurosci 7(1):30\u201340. https:\/\/doi.org\/10.1038\/nrn1809","journal-title":"Nat Rev Neurosci"},{"issue":"7728","key":"1991_CR20","doi-asserted-by":"publisher","first-page":"578","DOI":"10.1038\/s41586-018-0543-y","volume":"562","author":"TJ Bussian","year":"2018","unstructured":"Bussian TJ, Aziz A, Meyer CF, Swenson BL, van Deursen JM, Baker DJ (2018) Clearance of senescent glial cells prevents tau-dependent pathology and cognitive decline. Nature 562(7728):578\u2013582. https:\/\/doi.org\/10.1038\/s41586-018-0543-y","journal-title":"Nature"},{"key":"1991_CR21","doi-asserted-by":"publisher","first-page":"126","DOI":"10.3389\/fncel.2018.00126","volume":"12","author":"HA Bustamante","year":"2018","unstructured":"Bustamante HA, Gonz\u00e1lez AE, Cerda-Troncoso C, Shaughnessy R, Otth C, Soza A, Burgos PV (2018) Interplay between the autophagy-lysosomal pathway and the ubiquitin-proteasome system: a target for therapeutic development in Alzheimer\u2019s disease. Front Cell Neurosci 12:126","journal-title":"Front Cell Neurosci"},{"issue":"21","key":"1991_CR22","doi-asserted-by":"publisher","first-page":"2161","DOI":"10.1212\/WNL.0000000000001617","volume":"84","author":"J Butchart","year":"2015","unstructured":"Butchart J, Brook L, Hopkins V, Teeling J, Puntener U, Culliford D, Sharples R, Sharif S, McFarlane B, Raybould R, Thomas R, Passmore P, Perry VH, Holmes C (2015) Etanercept in Alzheimer disease: a randomized, placebo-controlled, double-blind, phase 2 trial. Neurology 84(21):2161\u20132168. https:\/\/doi.org\/10.1212\/WNL.0000000000001617","journal-title":"Neurology"},{"issue":"3","key":"1991_CR23","doi-asserted-by":"publisher","first-page":"148","DOI":"10.1038\/s41583-019-0132-6","volume":"20","author":"DA Butterfield","year":"2019","unstructured":"Butterfield DA, Halliwell B (2019) Oxidative stress, dysfunctional glucose metabolism and Alzheimer disease. Nat Rev Neurosci 20(3):148\u2013160","journal-title":"Nat Rev Neurosci"},{"issue":"11","key":"1991_CR24","doi-asserted-by":"publisher","first-page":"701","DOI":"10.1038\/s41583-018-0068-2","volume":"19","author":"R Cabeza","year":"2018","unstructured":"Cabeza R, Albert M, Belleville S, Craik FI, Duarte A, Grady CL, Lindenberger U, Nyberg L, Park DC, Reuter-Lorenz PA (2018) Maintenance, reserve and compensation: the cognitive neuroscience of healthy ageing. Nat Rev Neurosci 19(11):701\u2013710","journal-title":"Nat Rev Neurosci"},{"key":"1991_CR25","unstructured":"Catala-Lopez F, Collaborators GDF (2022) Estimation of the global prevalence of dementia in 2019 and forecasted prevalence in 2050: an analysis for the Global Burden of Disease Study 2019"},{"issue":"2","key":"1991_CR26","doi-asserted-by":"publisher","first-page":"468","DOI":"10.1016\/j.neuroimage.2010.12.032","volume":"55","author":"JJ Chen","year":"2011","unstructured":"Chen JJ, Rosas HD, Salat DH (2011a) Age-associated reductions in cerebral blood flow are independent from regional atrophy. Neuroimage 55(2):468\u2013478","journal-title":"Neuroimage"},{"issue":"2","key":"1991_CR27","doi-asserted-by":"publisher","first-page":"468","DOI":"10.1016\/j.neuroimage.2010.12.032","volume":"55","author":"JJ Chen","year":"2011","unstructured":"Chen JJ, Rosas HD, Salat DH (2011b) Age-associated reductions in cerebral blood flow are independent from regional atrophy. Neuroimage 55(2):468\u2013478. https:\/\/doi.org\/10.1016\/j.neuroimage.2010.12.032","journal-title":"Neuroimage"},{"issue":"10","key":"1991_CR28","doi-asserted-by":"publisher","first-page":"1215","DOI":"10.1001\/jamaneurol.2018.1836","volume":"75","author":"MK Chen","year":"2018","unstructured":"Chen MK, Mecca AP, Naganawa M, Finnema SJ, Toyonaga T, Lin SF, Najafzadeh S, Ropchan J, Lu Y, McDonald JW, Michalak HR, Nabulsi NB, Arnsten AFT, Huang Y, Carson RE, van Dyck CH (2018) Assessing synaptic density in Alzheimer disease with synaptic vesicle glycoprotein 2A positron emission tomographic imaging. JAMA Neurol 75(10):1215\u20131224. https:\/\/doi.org\/10.1001\/jamaneurol.2018.1836","journal-title":"JAMA Neurol"},{"issue":"9","key":"1991_CR29","doi-asserted-by":"publisher","first-page":"e1534","DOI":"10.1016\/S2214-109X(24)00264-X","volume":"12","author":"S Chen","year":"2024","unstructured":"Chen S, Cao Z, Nandi A, Counts N, Jiao L, Prettner K, Kuhn M, Seligman B, Tortorice D, Vigo D, Wang C, Bloom DE (2024) The global macroeconomic burden of Alzheimer\u2019s disease and other dementias: estimates and projections for 152 countries or territories. Lancet Glob Health 12(9):e1534\u2013e1543. https:\/\/doi.org\/10.1016\/S2214-109X(24)00264-X","journal-title":"Lancet Glob Health"},{"key":"1991_CR30","doi-asserted-by":"publisher","DOI":"10.1186\/s13024-015-0010-2","volume":"10","author":"D Chiasserini","year":"2015","unstructured":"Chiasserini D, Paciotti S, Eusebi P, Persichetti E, Tasegian A, Kurzawa-Akanbi M, Chinnery PF, Morris CM, Calabresi P, Parnetti L, Beccari T (2015) Selective loss of glucocerebrosidase activity in sporadic Parkinson\u2019s disease and dementia with Lewy bodies. Mol Neurodegener 10:15. https:\/\/doi.org\/10.1186\/s13024-015-0010-2","journal-title":"Mol Neurodegener"},{"issue":"10","key":"1991_CR31","doi-asserted-by":"publisher","first-page":"718","DOI":"10.1038\/nrd.2017.116","volume":"16","author":"BG Childs","year":"2017","unstructured":"Childs BG, Gluscevic M, Baker DJ, Laberge RM, Marquess D, Dananberg J, van Deursen JM (2017) Senescent cells: an emerging target for diseases of ageing. Nat Rev Drug Discov 16(10):718\u2013735. https:\/\/doi.org\/10.1038\/nrd.2017.116","journal-title":"Nat Rev Drug Discov"},{"key":"1991_CR32","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1016\/j.exger.2014.09.018","volume":"68","author":"SJ Chinta","year":"2015","unstructured":"Chinta SJ, Woods G, Rane A, Demaria M, Campisi J, Andersen JK (2015) Cellular senescence and the aging brain. Exp Gerontol 68:3\u20137","journal-title":"Exp Gerontol"},{"key":"1991_CR34","doi-asserted-by":"publisher","unstructured":"Claesson MJ, Jeffery IB, Conde S, Power SE, O'Connor EM, Cusack S, Harris HM, Coakley M, Lakshminarayanan B, O'Sullivan O, Fitzgerald GF, Deane J, O'Connor M, Harnedy N, O'Connor K, O'Mahony D, van Sinderen D, Wallace M, Brennan L et al (2012) Gut microbiota composition correlates with diet and health in the elderly. Nature 488(7410):178\u2013184. https:\/\/doi.org\/10.1038\/nature11319","DOI":"10.1038\/nature11319"},{"key":"1991_CR35","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1016\/j.arr.2016.05.004","volume":"32","author":"DJ Colacurcio","year":"2016","unstructured":"Colacurcio DJ, Nixon RA (2016) Disorders of lysosomal acidification-the emerging role of v-ATPase in aging and neurodegenerative disease. Ageing Res Rev 32:75\u201388. https:\/\/doi.org\/10.1016\/j.arr.2016.05.004","journal-title":"Ageing Res Rev"},{"issue":"2","key":"1991_CR36","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1001\/jamaneurol.2020.4152","volume":"78","author":"GUND Collaborators","year":"2021","unstructured":"Collaborators GUND, Feigin VL, Vos T, Alahdab F, Amit AML, Barnighausen TW, Beghi E, Beheshti M, Chavan PP, Criqui MH, Desai R, DhammindaDharmaratne S, Dorsey ER, Wilder Eagan A, Elgendy IY, Filip I, Giampaoli S, Giussani G, Hafezi-Nejad N et al (2021) Burden of neurological disorders across the US from 1990\u20132017: a global burden of disease study. JAMA Neurol 78(2):165\u2013176. https:\/\/doi.org\/10.1001\/jamaneurol.2020.4152","journal-title":"JAMA Neurol"},{"issue":"5123","key":"1991_CR37","doi-asserted-by":"publisher","first-page":"921","DOI":"10.1126\/science.8346443","volume":"261","author":"EH Corder","year":"1993","unstructured":"Corder EH, Saunders AM, Strittmatter WJ, Schmechel DE, Gaskell PC, Small G, Roses A, Haines J, Pericak-Vance MA (1993) Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer\u2019s disease in late onset families. Science 261(5123):921\u2013923","journal-title":"Science"},{"issue":"4","key":"1991_CR38","doi-asserted-by":"publisher","first-page":"1877","DOI":"10.1152\/physrev.00018.2018","volume":"99","author":"JF Cryan","year":"2019","unstructured":"Cryan JF, O\u2019Riordan KJ, Cowan CSM, Sandhu KV, Bastiaanssen TFS, Boehme M, Codagnone MG, Cussotto S, Fulling C, Golubeva AV, Guzzetta KE, Jaggar M, Long-Smith CM, Lyte JM, Martin JA, Molinero-Perez A, Moloney G, Morelli E, Morillas E, O\u2019Connor R, Cruz-Pereira JS, Peterson VL, Rea K, Ritz NL, Sherwin E, Spichak S, Teichman EM, van de Wouw M, Ventura-Silva AP, Wallace-Fitzsimons SE, Hyland N, Clarke G, Dinan TG (2019) The microbiota-gut-brain axis. Physiol Rev 99(4):1877\u20132013. https:\/\/doi.org\/10.1152\/physrev.00018.2018","journal-title":"Physiol Rev"},{"issue":"7","key":"1991_CR39","doi-asserted-by":"publisher","first-page":"569","DOI":"10.1007\/s40265-023-01858-9","volume":"83","author":"J Cummings","year":"2023","unstructured":"Cummings J (2023) Anti-amyloid monoclonal antibodies are transformative treatments that redefine Alzheimer\u2019s disease therapeutics. Drugs 83(7):569\u2013576","journal-title":"Drugs"},{"issue":"8","key":"1991_CR40","doi-asserted-by":"publisher","first-page":"461","DOI":"10.1038\/s41575-019-0157-3","volume":"16","author":"B Dalile","year":"2019","unstructured":"Dalile B, Van Oudenhove L, Vervliet B, Verbeke K (2019) The role of short-chain fatty acids in microbiota-gut-brain communication. Nat Rev Gastroenterol Hepatol 16(8):461\u2013478. https:\/\/doi.org\/10.1038\/s41575-019-0157-3","journal-title":"Nat Rev Gastroenterol Hepatol"},{"issue":"2","key":"1991_CR41","doi-asserted-by":"publisher","first-page":"531","DOI":"10.1172\/JCI64595","volume":"123","author":"FG De Felice","year":"2013","unstructured":"De Felice FG (2013) Alzheimer\u2019s disease and insulin resistance: translating basic science into clinical applications. J Clin Invest 123(2):531\u2013539","journal-title":"J Clin Invest"},{"issue":"2","key":"1991_CR42","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1016\/j.neuron.2011.09.011","volume":"72","author":"M DeJesus-Hernandez","year":"2011","unstructured":"DeJesus-Hernandez M, Mackenzie IR, Boeve BF, Boxer AL, Baker M, Rutherford NJ, Nicholson AM, Finch NA, Flynn H, Adamson J (2011) Expanded GGGGCC hexanucleotide repeat in noncoding region of C9ORF72 causes chromosome 9p-linked FTD and ALS. Neuron 72(2):245\u2013256","journal-title":"Neuron"},{"issue":"4","key":"1991_CR43","doi-asserted-by":"publisher","first-page":"425","DOI":"10.2174\/1871527316666170124165222","volume":"16","author":"L Dezsi","year":"2017","unstructured":"Dezsi L, Vecsei L (2017) Monoamine oxidase B inhibitors in Parkinson\u2019s disease. CNS Neurol Disord Drug Targets 16(4):425\u2013439. https:\/\/doi.org\/10.2174\/1871527316666170124165222","journal-title":"CNS Neurol Disord Drug Targets"},{"issue":"4","key":"1991_CR44","doi-asserted-by":"publisher","first-page":"932","DOI":"10.1189\/jlb.0208108","volume":"84","author":"RN Dilger","year":"2008","unstructured":"Dilger RN, Johnson RW (2008) Aging, microglial cell priming, and the discordant central inflammatory response to signals from the peripheral immune system. J Leukoc Biol 84(4):932\u2013939. https:\/\/doi.org\/10.1189\/jlb.0208108","journal-title":"J Leukoc Biol"},{"issue":"11","key":"1991_CR45","doi-asserted-by":"publisher","first-page":"939","DOI":"10.1016\/S1474-4422(18)30295-3","volume":"17","author":"ER Dorsey","year":"2018","unstructured":"Dorsey ER, Elbaz A, Nichols E, Abbasi N, Abd-Allah F, Abdelalim A, Adsuar JC, Ansha MG, Brayne C, Choi J-YJ (2018a) Global, regional, and national burden of Parkinson\u2019s disease, 1990\u20132016: a systematic analysis for the Global burden of Disease Study 2016. Lancet Neurol 17(11):939\u2013953","journal-title":"Lancet Neurol"},{"issue":"s1","key":"1991_CR46","doi-asserted-by":"publisher","first-page":"S3","DOI":"10.3233\/JPD-181474","volume":"8","author":"ER Dorsey","year":"2018","unstructured":"Dorsey ER, Sherer T, Okun MS, Bloem BR (2018b) The emerging evidence of the Parkinson pandemic. J Parkinsons Dis 8(s1):S3\u2013S8. https:\/\/doi.org\/10.3233\/JPD-181474","journal-title":"J Parkinsons Dis"},{"issue":"7","key":"1991_CR47","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a028035","volume":"9","author":"BN Dugger","year":"2017","unstructured":"Dugger BN, Dickson DW (2017) Pathology of neurodegenerative diseases. Cold Spring Harb Perspect Biol 9(7):a028035. https:\/\/doi.org\/10.1101\/cshperspect.a028035","journal-title":"Cold Spring Harb Perspect Biol"},{"key":"1991_CR48","doi-asserted-by":"publisher","first-page":"118","DOI":"10.1016\/j.addr.2017.07.016","volume":"120","author":"JM Encinas","year":"2017","unstructured":"Encinas JM, Fitzsimons CP (2017) Gene regulation in adult neural stem cells. current challenges and possible applications. Adv Drug Deliv Rev 120:118\u2013132. https:\/\/doi.org\/10.1016\/j.addr.2017.07.016","journal-title":"Adv Drug Deliv Rev"},{"issue":"10","key":"1991_CR49","doi-asserted-by":"publisher","first-page":"1500","DOI":"10.1038\/jcbfm.2013.135","volume":"33","author":"MA Erickson","year":"2013","unstructured":"Erickson MA, Banks WA (2013) Blood\u2013brain barrier dysfunction as a cause and consequence of Alzheimer\u2019s disease. J Cereb Blood Flow Metab 33(10):1500\u20131513","journal-title":"J Cereb Blood Flow Metab"},{"key":"1991_CR50","unstructured":"Escap U (2022) Asia-Pacific report on population ageing 2022: trends, policies and good practices regarding older persons and population ageing"},{"key":"1991_CR51","doi-asserted-by":"publisher","first-page":"50","DOI":"10.3389\/neuro.22.002.2009","volume":"3","author":"K Fabel","year":"2009","unstructured":"Fabel K, Wolf SA, Ehninger D, Babu H, Leal-Galicia P, Kempermann G (2009) Additive effects of physical exercise and environmental enrichment on adult hippocampal neurogenesis in mice. Front Neurosci 3:50. https:\/\/doi.org\/10.3389\/neuro.22.002.2009","journal-title":"Front Neurosci"},{"issue":"5","key":"1991_CR52","doi-asserted-by":"publisher","first-page":"508","DOI":"10.2174\/1570159X15666170720095240","volume":"16","author":"M Fakhoury","year":"2018","unstructured":"Fakhoury M (2018) Microglia and astrocytes in Alzheimer\u2019s disease: implications for therapy. Curr Neuropharmacol 16(5):508\u2013518","journal-title":"Curr Neuropharmacol"},{"issue":"4","key":"1991_CR53","doi-asserted-by":"publisher","first-page":"713","DOI":"10.1038\/cdd.2011.143","volume":"19","author":"R Faraonio","year":"2012","unstructured":"Faraonio R, Salerno P, Passaro F, Sedia C, Iaccio A, Bellelli R, Nappi TC, Comegna M, Romano S, Salvatore G, Santoro M, Cimino F (2012) A set of miRNAs participates in the cellular senescence program in human diploid fibroblasts. Cell Death Differ 19(4):713\u2013721. https:\/\/doi.org\/10.1038\/cdd.2011.143","journal-title":"Cell Death Differ"},{"issue":"10","key":"1991_CR54","doi-asserted-by":"publisher","first-page":"576","DOI":"10.1038\/s41574-018-0059-4","volume":"14","author":"C Franceschi","year":"2018","unstructured":"Franceschi C, Garagnani P, Parini P, Giuliani C, Santoro A (2018a) Inflammaging: a new immune-metabolic viewpoint for age-related diseases. Nat Rev Endocrinol 14(10):576\u2013590. https:\/\/doi.org\/10.1038\/s41574-018-0059-4","journal-title":"Nat Rev Endocrinol"},{"issue":"10","key":"1991_CR55","doi-asserted-by":"publisher","first-page":"576","DOI":"10.1038\/s41574-018-0059-4","volume":"14","author":"C Franceschi","year":"2018","unstructured":"Franceschi C, Garagnani P, Parini P, Giuliani C, Santoro A (2018b) Inflammaging: a new immune\u2013metabolic viewpoint for age-related diseases. Nat Rev Endocrinol 14(10):576\u2013590","journal-title":"Nat Rev Endocrinol"},{"key":"1991_CR56","doi-asserted-by":"publisher","first-page":"342","DOI":"10.3389\/fnins.2018.00342","volume":"12","author":"S Franco-Iborra","year":"2018","unstructured":"Franco-Iborra S, Vila M, Perier C (2018) Mitochondrial quality control in neurodegenerative diseases: focus on Parkinson\u2019s disease and Huntington\u2019s disease. Front Neurosci 12:342","journal-title":"Front Neurosci"},{"issue":"8","key":"1991_CR57","doi-asserted-by":"publisher","first-page":"870","DOI":"10.1136\/jnnp-2018-320106","volume":"90","author":"L Gaetani","year":"2019","unstructured":"Gaetani L, Blennow K, Calabresi P, Di Filippo M, Parnetti L, Zetterberg H (2019) Neurofilament light chain as a biomarker in neurological disorders. J Neurol Neurosurg Psychiatry 90(8):870\u2013881","journal-title":"J Neurol Neurosurg Psychiatry"},{"issue":"4","key":"1991_CR58","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a024224","volume":"8","author":"TF Gendron","year":"2018","unstructured":"Gendron TF, Petrucelli L (2018) Disease mechanisms of C9ORF72 repeat expansions. Cold Spring Harb Perspect Med 8(4):a024224. https:\/\/doi.org\/10.1101\/cshperspect.a024224","journal-title":"Cold Spring Harb Perspect Med"},{"issue":"2","key":"1991_CR59","doi-asserted-by":"publisher","DOI":"10.1111\/acel.13549","volume":"21","author":"P Gomez-Suaga","year":"2022","unstructured":"Gomez-Suaga P, Morotz GM, Markovinovic A, Martin-Guerrero SM, Preza E, Arias N, Mayl K, Aabdien A, Gesheva V, Nishimura A, Annibali A, Lee Y, Mitchell JC, Wray S, Shaw C, Noble W, Miller CCJ (2022) Disruption of ER-mitochondria tethering and signalling in C9orf72-associated amyotrophic lateral sclerosis and frontotemporal dementia. Aging Cell 21(2):e13549. https:\/\/doi.org\/10.1111\/acel.13549","journal-title":"Aging Cell"},{"issue":"12","key":"1991_CR60","doi-asserted-by":"publisher","first-page":"1045","DOI":"10.1016\/S1474-4422(07)70270-3","volume":"6","author":"PH Gordon","year":"2007","unstructured":"Gordon PH, Moore DH, Miller RG, Florence JM, Verheijde JL, Doorish C, Hilton JF, Spitalny GM, MacArthur RB, Mitsumoto H, Neville HE, Boylan K, Mozaffar T, Belsh JM, Ravits J, Bedlack RS, Graves MC, McCluskey LF, Barohn RJ, Tandan R (2007) Efficacy of minocycline in patients with amyotrophic lateral sclerosis: a phase III randomised trial. Lancet Neurol 6(12):1045\u20131053. https:\/\/doi.org\/10.1016\/S1474-4422(07)70270-3","journal-title":"Lancet Neurol"},{"issue":"9","key":"1991_CR61","doi-asserted-by":"publisher","first-page":"573","DOI":"10.1038\/s41577-019-0180-1","volume":"19","author":"JJ Goronzy","year":"2019","unstructured":"Goronzy JJ, Weyand CM (2019) Mechanisms underlying T cell ageing. Nat Rev Immunol 19(9):573\u2013583. https:\/\/doi.org\/10.1038\/s41577-019-0180-1","journal-title":"Nat Rev Immunol"},{"issue":"1\u20132","key":"1991_CR62","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1016\/j.cell.2013.12.020","volume":"156","author":"J Graff","year":"2014","unstructured":"Graff J, Joseph NF, Horn ME, Samiei A, Meng J, Seo J, Rei D, Bero AW, Phan TX, Wagner F, Holson E, Xu J, Sun J, Neve RL, Mach RH, Haggarty SJ, Tsai LH (2014) Epigenetic priming of memory updating during reconsolidation to attenuate remote fear memories. Cell 156(1\u20132):261\u2013276. https:\/\/doi.org\/10.1016\/j.cell.2013.12.020","journal-title":"Cell"},{"issue":"9949","key":"1991_CR63","doi-asserted-by":"publisher","first-page":"1196","DOI":"10.1016\/S0140-6736(14)60683-8","volume":"384","author":"Group PMC","year":"2014","unstructured":"Group PMC (2014) Long-term effectiveness of dopamine agonists and monoamine oxidase B inhibitors compared with levodopa as initial treatment for Parkinson\u2019s disease (PD MED): a large, open-label, pragmatic randomised trial. Lancet 384(9949):1196\u20131205","journal-title":"Lancet"},{"issue":"12","key":"1991_CR64","doi-asserted-by":"publisher","first-page":"2087","DOI":"10.1038\/s41593-019-0539-4","volume":"22","author":"A Grubman","year":"2019","unstructured":"Grubman A, Chew G, Ouyang JF, Sun G, Choo XY, McLean C, Simmons RK, Buckberry S, Vargas-Landin DB, Poppe D (2019) A single-cell atlas of entorhinal cortex from individuals with Alzheimer\u2019s disease reveals cell-type-specific gene expression regulation. Nat Neurosci 22(12):2087\u20132097","journal-title":"Nat Neurosci"},{"key":"1991_CR65","unstructured":"Grynoch T, MacKenzie K (2022) Data and Code from"},{"issue":"35","key":"1991_CR66","doi-asserted-by":"publisher","first-page":"37043","DOI":"10.18632\/oncotarget.6158","volume":"6","author":"Y Gui","year":"2015","unstructured":"Gui Y, Liu H, Zhang L, Lv W, Hu X (2015) Altered microRNA profiles in cerebrospinal fluid exosome in Parkinson disease and Alzheimer disease. Oncotarget 6(35):37043","journal-title":"Oncotarget"},{"issue":"3","key":"1991_CR67","doi-asserted-by":"publisher","first-page":"1039","DOI":"10.1016\/j.neuroscience.2010.05.049","volume":"169","author":"J Han","year":"2010","unstructured":"Han J, Miyamae Y, Shigemori H, Isoda H (2010) Neuroprotective effect of 3, 5-di-O-caffeoylquinic acid on SH-SY5Y cells and senescence-accelerated-prone mice 8 through the up-regulation of phosphoglycerate kinase-1. Neuroscience 169(3):1039\u20131045","journal-title":"Neuroscience"},{"key":"1991_CR68","doi-asserted-by":"crossref","unstructured":"Harman D (2002) Aging: a theory based on free radical and radiation chemistry. Sci Aging Knowl Environ 2002(37):cp14\u2013cp14","DOI":"10.1126\/sageke.2002.37.cp14"},{"issue":"3","key":"1991_CR69","doi-asserted-by":"publisher","first-page":"436","DOI":"10.1111\/jnc.13657","volume":"138","author":"XF He","year":"2016","unstructured":"He XF, Lan Y, Zhang Q, Liu DX, Wang Q, Liang FY, Zeng JS, Xu GQ, Pei Z (2016) Deferoxamine inhibits microglial activation, attenuates blood-brain barrier disruption, rescues dendritic damage, and improves spatial memory in a mouse model of microhemorrhages. J Neurochem 138(3):436\u2013447. https:\/\/doi.org\/10.1111\/jnc.13657","journal-title":"J Neurochem"},{"issue":"19","key":"1991_CR70","doi-asserted-by":"publisher","first-page":"1778","DOI":"10.1212\/WNL.0b013e31828726f5","volume":"80","author":"LE Hebert","year":"2013","unstructured":"Hebert LE, Weuve J, Scherr PA, Evans DA (2013) Alzheimer disease in the United States (2010\u20132050) estimated using the 2010 census. Neurology 80(19):1778\u20131783. https:\/\/doi.org\/10.1212\/WNL.0b013e31828726f5","journal-title":"Neurology"},{"issue":"7","key":"1991_CR71","doi-asserted-by":"publisher","first-page":"463","DOI":"10.1038\/nri3705","volume":"14","author":"MT Heneka","year":"2014","unstructured":"Heneka MT, Kummer MP, Latz E (2014) Innate immune activation in neurodegenerative disease. Nat Rev Immunol 14(7):463\u2013477. https:\/\/doi.org\/10.1038\/nri3705","journal-title":"Nat Rev Immunol"},{"issue":"10","key":"1991_CR72","doi-asserted-by":"publisher","first-page":"R115","DOI":"10.1186\/gb-2013-14-10-r115","volume":"14","author":"S Horvath","year":"2013","unstructured":"Horvath S (2013a) DNA methylation age of human tissues and cell types. Genome Biol 14(10):R115. https:\/\/doi.org\/10.1186\/gb-2013-14-10-r115","journal-title":"Genome Biol"},{"key":"1991_CR73","unstructured":"Horvath S (2013) DNA Methylation data involving healthy (Non-Cancer) tissue"},{"issue":"10","key":"1991_CR74","doi-asserted-by":"publisher","first-page":"565","DOI":"10.1038\/s41582-019-0244-7","volume":"15","author":"Y Hou","year":"2019","unstructured":"Hou Y, Dan X, Babbar M, Wei Y, Hasselbalch SG, Croteau DL, Bohr VA (2019) Ageing as a risk factor for neurodegenerative disease. Nat Rev Neurol 15(10):565\u2013581","journal-title":"Nat Rev Neurol"},{"issue":"10","key":"1991_CR75","doi-asserted-by":"publisher","first-page":"893","DOI":"10.1056\/NEJMoa1106668","volume":"366","author":"R Howard","year":"2012","unstructured":"Howard R, McShane R, Lindesay J, Ritchie C, Baldwin A, Barber R, Burns A, Dening T, Findlay D, Holmes C, Hughes A, Jacoby R, Jones R, Jones R, McKeith I, Macharouthu A, O\u2019Brien J, Passmore P, Sheehan B, Juszczak E, Katona C, Hills R, Knapp M, Ballard C, Brown R, Banerjee S, Onions C, Griffin M, Adams J, Gray R, Johnson T, Bentham P, Phillips P (2012) Donepezil and memantine for moderate-to-severe Alzheimer\u2019s disease. N Engl J Med 366(10):893\u2013903. https:\/\/doi.org\/10.1056\/NEJMoa1106668","journal-title":"N Engl J Med"},{"issue":"2","key":"1991_CR76","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1016\/S1474-4422(12)70291-0","volume":"12","author":"CR Jack Jr","year":"2013","unstructured":"Jack CR Jr, Knopman DS, Jagust WJ, Petersen RC, Weiner MW, Aisen PS, Shaw LM, Vemuri P, Wiste HJ, Weigand SD (2013) Update on hypothetical model of Alzheimer\u2019s disease biomarkers. Lancet Neurol 12(2):207","journal-title":"Lancet Neurol"},{"key":"1991_CR77","doi-asserted-by":"crossref","unstructured":"Jafari Z, Mahood Q, Hamson A (2023) Riluzole for amyotrophic lateral sclerosis treatment. Can J Health Technol 3(7)","DOI":"10.51731\/cjht.2023.680"},{"issue":"7","key":"1991_CR78","doi-asserted-by":"publisher","first-page":"520","DOI":"10.1038\/s41551-019-0397-0","volume":"3","author":"S Jalili-Firoozinezhad","year":"2019","unstructured":"Jalili-Firoozinezhad S, Gazzaniga FS, Calamari EL, Camacho DM, Fadel CW, Bein A, Swenor B, Nestor B, Cronce MJ, Tovaglieri A (2019) A complex human gut microbiome cultured in an anaerobic intestine-on-a-chip. Nat Biomed Eng 3(7):520\u2013531","journal-title":"Nat Biomed Eng"},{"issue":"3","key":"1991_CR79","doi-asserted-by":"publisher","first-page":"379","DOI":"10.1038\/s41591-020-0755-1","volume":"26","author":"S Janelidze","year":"2020","unstructured":"Janelidze S, Mattsson N, Palmqvist S, Smith R, Beach TG, Serrano GE, Chai X, Proctor NK, Eichenlaub U, Zetterberg H (2020a) Plasma P-tau181 in Alzheimer\u2019s disease: relationship to other biomarkers, differential diagnosis, neuropathology and longitudinal progression to Alzheimer\u2019s dementia. Nat Med 26(3):379\u2013386","journal-title":"Nat Med"},{"issue":"1","key":"1991_CR80","doi-asserted-by":"publisher","first-page":"1683","DOI":"10.1038\/s41467-020-15436-0","volume":"11","author":"S Janelidze","year":"2020","unstructured":"Janelidze S, Stomrud E, Smith R, Palmqvist S, Mattsson N, Airey DC, Proctor NK, Chai X, Shcherbinin S, Sims JR (2020b) Cerebrospinal fluid p-tau217 performs better than p-tau181 as a biomarker of Alzheimer\u2019s disease. Nat Commun 11(1):1683","journal-title":"Nat Commun"},{"issue":"10","key":"1991_CR81","doi-asserted-by":"publisher","first-page":"1341","DOI":"10.1038\/s41593-018-0238-6","volume":"21","author":"M Jucker","year":"2018","unstructured":"Jucker M, Walker LC (2018) Propagation and spread of pathogenic protein assemblies in neurodegenerative diseases. Nat Neurosci 21(10):1341\u20131349","journal-title":"Nat Neurosci"},{"issue":"4","key":"1991_CR82","doi-asserted-by":"publisher","first-page":"374","DOI":"10.1136\/jnnp-2017-316365","volume":"89","author":"J Kassubek","year":"2018","unstructured":"Kassubek J, Muller HP, Del Tredici K, Lule D, Gorges M, Braak H, Ludolph AC (2018) Imaging the pathoanatomy of amyotrophic lateral sclerosis in vivo: targeting a propagation-based biological marker. J Neurol Neurosurg Psychiatry 89(4):374\u2013381. https:\/\/doi.org\/10.1136\/jnnp-2017-316365","journal-title":"J Neurol Neurosurg Psychiatry"},{"issue":"6","key":"1991_CR83","doi-asserted-by":"publisher","first-page":"747","DOI":"10.1002\/mds.26246","volume":"30","author":"M Kasten","year":"2015","unstructured":"Kasten M, Klein C (2015) Genetic risk loci for Parkinson\u2019s disease: moving from state to trait? Mov Disord 30(6):747\u2013749. https:\/\/doi.org\/10.1002\/mds.26246","journal-title":"Mov Disord"},{"key":"1991_CR84","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1016\/j.ebiom.2017.04.013","volume":"21","author":"JL Kirkland","year":"2017","unstructured":"Kirkland JL, Tchkonia T (2017) Cellular senescence: a translational perspective. EBioMedicine 21:21\u201328. https:\/\/doi.org\/10.1016\/j.ebiom.2017.04.013","journal-title":"EBioMedicine"},{"issue":"3","key":"1991_CR85","doi-asserted-by":"publisher","first-page":"306","DOI":"10.1002\/ana.20009","volume":"55","author":"WE Klunk","year":"2004","unstructured":"Klunk WE, Engler H, Nordberg A, Wang Y, Blomqvist G, Holt DP, Bergstrom M, Savitcheva I, Huang GF, Estrada S, Ausen B, Debnath ML, Barletta J, Price JC, Sandell J, Lopresti BJ, Wall A, Koivisto P, Antoni G et al (2004) Imaging brain amyloid in Alzheimer\u2019s disease with Pittsburgh compound-b. Ann Neurol 55(3):306\u2013319. https:\/\/doi.org\/10.1002\/ana.20009","journal-title":"Ann Neurol"},{"issue":"4","key":"1991_CR86","doi-asserted-by":"publisher","first-page":"475","DOI":"10.1177\/08919887211044746","volume":"35","author":"AL Knorz","year":"2022","unstructured":"Knorz AL, Quante A (2022) Alzheimer\u2019s disease: efficacy of mono- and combination therapy. A systematic review. J Geriatr Psychiatry Neurol 35(4):475\u2013486. https:\/\/doi.org\/10.1177\/08919887211044746","journal-title":"J Geriatr Psychiatry Neurol"},{"issue":"1","key":"1991_CR87","doi-asserted-by":"publisher","first-page":"13510","DOI":"10.1038\/s41598-017-13368-2","volume":"7","author":"Y Kobayashi","year":"2017","unstructured":"Kobayashi Y, Sugahara H, Shimada K, Mitsuyama E, Kuhara T, Yasuoka A, Kondo T, Abe K, Xiao JZ (2017) Therapeutic potential of Bifidobacterium breve strain A1 for preventing cognitive impairment in Alzheimer\u2019s disease. Sci Rep 7(1):13510. https:\/\/doi.org\/10.1038\/s41598-017-13368-2","journal-title":"Sci Rep"},{"issue":"1","key":"1991_CR88","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1111\/ene.13439","volume":"25","author":"CA Lane","year":"2018","unstructured":"Lane CA, Hardy J, Schott JM (2018) Alzheimer\u2019s disease. Eur J Neurol 25(1):59\u201370","journal-title":"Eur J Neurol"},{"key":"1991_CR89","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1016\/j.pneurobio.2015.05.002","volume":"131","author":"R Lardenoije","year":"2015","unstructured":"Lardenoije R, Iatrou A, Kenis G, Kompotis K, Steinbusch HW, Mastroeni D, Coleman P, Lemere CA, Hof PR, van den Hove DL, Rutten BP (2015) The epigenetics of aging and neurodegeneration. Prog Neurobiol 131:21\u201364. https:\/\/doi.org\/10.1016\/j.pneurobio.2015.05.002","journal-title":"Prog Neurobiol"},{"issue":"23","key":"1991_CR90","doi-asserted-by":"publisher","first-page":"13012","DOI":"10.3390\/ijms222313012","volume":"22","author":"CY Lee","year":"2021","unstructured":"Lee CY, Ryu IS, Ryu J-H, Cho H-J (2021) Mirnas as therapeutic tools in Alzheimer\u2019s disease. Int J Mol Sci 22(23):13012","journal-title":"Int J Mol Sci"},{"issue":"1","key":"1991_CR91","doi-asserted-by":"publisher","first-page":"693","DOI":"10.1146\/annurev-immunol-090122-042631","volume":"43","author":"Y Lei","year":"2025","unstructured":"Lei Y, Tsang JS (2025) Systems human immunology and AI: immune setpoint and immune health. Annu Rev Immunol 43(1):693\u2013722. https:\/\/doi.org\/10.1146\/annurev-immunol-090122-042631","journal-title":"Annu Rev Immunol"},{"issue":"5","key":"1991_CR92","doi-asserted-by":"publisher","first-page":"929","DOI":"10.1016\/j.neuron.2012.12.040","volume":"77","author":"S Li","year":"2013","unstructured":"Li S, Jin M, Zhang D, Yang T, Koeglsperger T, Fu H, Selkoe DJ (2013) Environmental novelty activates beta2-adrenergic signaling to prevent the impairment of hippocampal LTP by Abeta oligomers. Neuron 77(5):929\u2013941. https:\/\/doi.org\/10.1016\/j.neuron.2012.12.040","journal-title":"Neuron"},{"issue":"14","key":"1991_CR93","doi-asserted-by":"publisher","first-page":"14157","DOI":"10.18632\/aging.103423","volume":"12","author":"X Li","year":"2020","unstructured":"Li X, Liu Y, Zhang X, Shen J, Xu R, Liu Y, Yu X (2020) Circular RNA hsa_circ_0000073 contributes to osteosarcoma cell proliferation, migration, invasion and methotrexate resistance by sponging miR-145-5p and miR-151-3p and upregulating NRAS. Aging (Albany NY) 12(14):14157\u201314173. https:\/\/doi.org\/10.18632\/aging.103423","journal-title":"Aging (Albany NY)"},{"issue":"6","key":"1991_CR94","doi-asserted-by":"publisher","first-page":"957","DOI":"10.1016\/j.immuni.2017.06.006","volume":"46","author":"SA Liddelow","year":"2017","unstructured":"Liddelow SA, Barres BA (2017) Reactive astrocytes: production, function, and therapeutic potential. Immunity 46(6):957\u2013967. https:\/\/doi.org\/10.1016\/j.immuni.2017.06.006","journal-title":"Immunity"},{"issue":"7","key":"1991_CR95","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a041356","volume":"16","author":"SA Liddelow","year":"2024","unstructured":"Liddelow SA, Olsen ML, Sofroniew MV (2024) Reactive astrocytes and emerging roles in central nervous system (CNS) disorders. Cold Spring Harb Perspect Biol 16(7):a041356. https:\/\/doi.org\/10.1101\/cshperspect.a041356","journal-title":"Cold Spring Harb Perspect Biol"},{"issue":"32","key":"1991_CR96","doi-asserted-by":"publisher","first-page":"14164","DOI":"10.1073\/pnas.1009485107","volume":"107","author":"MM Lipinski","year":"2010","unstructured":"Lipinski MM, Zheng B, Lu T, Yan Z, Py BF, Ng A, Xavier RJ, Li C, Yankner BA, Scherzer CR, Yuan J (2010) Genome-wide analysis reveals mechanisms modulating autophagy in normal brain aging and in Alzheimer\u2019s disease. Proc Natl Acad Sci USA 107(32):14164\u201314169. https:\/\/doi.org\/10.1073\/pnas.1009485107","journal-title":"Proc Natl Acad Sci USA"},{"issue":"1","key":"1991_CR97","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1152\/jappl.2000.89.1.21","volume":"89","author":"J Liu","year":"2000","unstructured":"Liu J, Yeo HC, Overvik-Douki E, Hagen T, Doniger SJ, Chu DW, Brooks GA, Ames BN (2000) Chronically and acutely exercised rats: biomarkers of oxidative stress and endogenous antioxidants. J Appl Physiol 89(1):21\u201328","journal-title":"J Appl Physiol"},{"issue":"15","key":"1991_CR98","doi-asserted-by":"publisher","first-page":"3431","DOI":"10.1113\/jphysiol.2012.232645","volume":"590","author":"JT Lock","year":"2012","unstructured":"Lock JT, Sinkins WG, Schilling WP (2012) Protein S-glutathionylation enhances Ca2+-induced Ca2+ release via the IP3 receptor in cultured aortic endothelial cells. J Physiol 590(15):3431\u20133447. https:\/\/doi.org\/10.1113\/jphysiol.2012.232645","journal-title":"J Physiol"},{"issue":"6375","key":"1991_CR99","doi-asserted-by":"publisher","first-page":"555","DOI":"10.1126\/science.aao4426","volume":"359","author":"MA Lodato","year":"2018","unstructured":"Lodato MA, Rodin RE, Bohrson CL, Coulter ME, Barton AR, Kwon M, Sherman MA, Vitzthum CM, Luquette LJ, Yandava CN, Yang P, Chittenden TW, Hatem NE, Ryu SC, Woodworth MB, Park PJ, Walsh CA (2018) Aging and neurodegeneration are associated with increased mutations in single human neurons. Science 359(6375):555\u2013559. https:\/\/doi.org\/10.1126\/science.aao4426","journal-title":"Science"},{"key":"1991_CR100","unstructured":"Long S, Benoist C, Weidner W (2023) World Alzheimer Report 2023: Reducing dementia risk: never too early, never too late. Alzheimer\u2019s Dis Int"},{"issue":"6","key":"1991_CR101","doi-asserted-by":"publisher","first-page":"1194","DOI":"10.1016\/j.cell.2013.05.039","volume":"153","author":"C L\u00f3pez-Ot\u00edn","year":"2013","unstructured":"L\u00f3pez-Ot\u00edn C, Blasco MA, Partridge L, Serrano M, Kroemer G (2013) The hallmarks of aging. Cell 153(6):1194\u20131217","journal-title":"Cell"},{"issue":"6","key":"1991_CR102","doi-asserted-by":"publisher","first-page":"1194","DOI":"10.1016\/j.cell.2013.05.039","volume":"153","author":"C Lopez-Otin","year":"2013","unstructured":"Lopez-Otin C, Blasco MA, Partridge L, Serrano M, Kroemer G (2013) The hallmarks of aging. Cell 153(6):1194\u20131217. https:\/\/doi.org\/10.1016\/j.cell.2013.05.039","journal-title":"Cell"},{"key":"1991_CR103","unstructured":"Lucke-Wold B, Seidel K, Udo R, Omalu B, Ornstein M, Nolan R, Rosen C, Ross J (2017) Role of tau acetylation in Alzheimer's disease and chronic traumatic encephalopathy: the way forward for Successful Treatment. J Neurol Neurosurg 4(2). https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/29276758"},{"key":"1991_CR104","doi-asserted-by":"crossref","unstructured":"Lv S, Li J, He H, Zhao Q, Jiang Y (2024) Artificial intelligence applications in delirium prediction, diagnosis, and management: a systematic review","DOI":"10.21203\/rs.3.rs-5082335\/v1"},{"issue":"5","key":"1991_CR105","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0321567","volume":"20","author":"M Ma","year":"2025","unstructured":"Ma M, Li B, Qu Z, Liu S, Li S (2025) Efficacy of probiotics in patients with cognitive impairment: a systematic review and meta-analysis. PLoS ONE 20(5):e0321567. https:\/\/doi.org\/10.1371\/journal.pone.0321567","journal-title":"PLoS ONE"},{"key":"1991_CR106","doi-asserted-by":"publisher","first-page":"1197212","DOI":"10.3389\/fneur.2023.1197212","volume":"14","author":"G Macaron","year":"2023","unstructured":"Macaron G, Larochelle C, Arbour N, Galmard M, Girard JM, Prat A, Duquette P (2023) Impact of aging on treatment considerations for multiple sclerosis patients. Front Neurol 14:1197212. https:\/\/doi.org\/10.3389\/fneur.2023.1197212","journal-title":"Front Neurol"},{"issue":"6","key":"1991_CR107","doi-asserted-by":"publisher","first-page":"1687","DOI":"10.1016\/j.neurobiolaging.2012.12.002","volume":"34","author":"CJ Mahoney","year":"2013","unstructured":"Mahoney CJ, Malone IB, Ridgway GR, Buckley AH, Downey LE, Golden HL, Ryan NS, Ourselin S, Schott JM, Rossor MN (2013) White matter tract signatures of the progressive aphasias. Neurobiol Aging 34(6):1687\u20131699","journal-title":"Neurobiol Aging"},{"key":"1991_CR108","doi-asserted-by":"crossref","unstructured":"Mahul-Mellier AL, Altay MF, Burtscher J, Maharjan N, Ait-Bouziad N, Chiki A, Vingill S, Wade-Martins R, Holton J, Strand C (2018) The making of a Lewy body: the role of \u03b1-synuclein post-fibrillization modifications in regulating the formation and the maturation of pathological inclusions. BioRxiv 500058","DOI":"10.1101\/500058"},{"issue":"7761","key":"1991_CR109","doi-asserted-by":"publisher","first-page":"332","DOI":"10.1038\/s41586-019-1195-2","volume":"570","author":"H Mathys","year":"2019","unstructured":"Mathys H, Davila-Velderrain J, Peng Z, Gao F, Mohammadi S, Young JZ, Menon M, He L, Abdurrob F, Jiang X (2019) Single-cell transcriptomic analysis of Alzheimer\u2019s disease. Nature 570(7761):332\u2013337","journal-title":"Nature"},{"issue":"6","key":"1991_CR110","doi-asserted-by":"publisher","first-page":"1176","DOI":"10.1016\/j.cmet.2018.05.011","volume":"27","author":"MP Mattson","year":"2018","unstructured":"Mattson MP, Arumugam TV (2018a) Hallmarks of brain aging: adaptive and pathological modification by metabolic states. Cell Metab 27(6):1176\u20131199. https:\/\/doi.org\/10.1016\/j.cmet.2018.05.011","journal-title":"Cell Metab"},{"issue":"6","key":"1991_CR111","doi-asserted-by":"publisher","first-page":"1176","DOI":"10.1016\/j.cmet.2018.05.011","volume":"27","author":"MP Mattson","year":"2018","unstructured":"Mattson MP, Arumugam TV (2018b) Hallmarks of brain aging: adaptive and pathological modification by metabolic states. Cell Metab 27(6):1176\u20131199","journal-title":"Cell Metab"},{"issue":"5","key":"1991_CR112","doi-asserted-by":"publisher","first-page":"557","DOI":"10.1001\/jamaneurol.2016.6117","volume":"74","author":"N Mattsson","year":"2017","unstructured":"Mattsson N, Andreasson U, Zetterberg H, Blennow K, Alzheimer\u2019s Disease Neuroimaging, I. (2017) Association of plasma neurofilament light with neurodegeneration in patients with Alzheimer disease. JAMA Neurol 74(5):557\u2013566. https:\/\/doi.org\/10.1001\/jamaneurol.2016.6117","journal-title":"JAMA Neurol"},{"issue":"1","key":"1991_CR113","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1111\/ene.13413","volume":"25","author":"P McColgan","year":"2018","unstructured":"McColgan P, Tabrizi SJ (2018) Huntington\u2019s disease: a clinical review. Eur J Neurol 25(1):24\u201334","journal-title":"Eur J Neurol"},{"issue":"6","key":"1991_CR114","doi-asserted-by":"publisher","first-page":"345","DOI":"10.1038\/nrn3961","volume":"16","author":"FM Menzies","year":"2015","unstructured":"Menzies FM, Fleming A, Rubinsztein DC (2015a) Compromised autophagy and neurodegenerative diseases. Nat Rev Neurosci 16(6):345\u2013357","journal-title":"Nat Rev Neurosci"},{"issue":"6","key":"1991_CR115","doi-asserted-by":"publisher","first-page":"345","DOI":"10.1038\/nrn3961","volume":"16","author":"FM Menzies","year":"2015","unstructured":"Menzies FM, Fleming A, Rubinsztein DC (2015b) Compromised autophagy and neurodegenerative diseases. Nat Rev Neurosci 16(6):345\u2013357. https:\/\/doi.org\/10.1038\/nrn3961","journal-title":"Nat Rev Neurosci"},{"key":"1991_CR116","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2014.00067","volume":"6","author":"A Milewski-Lopez","year":"2014","unstructured":"Milewski-Lopez A, Greco E, van den Berg F, McAvinue LP, McGuire S, Robertson IH (2014) An evaluation of alertness training for older adults. Front Aging Neurosci 6:67. https:\/\/doi.org\/10.3389\/fnagi.2014.00067","journal-title":"Front Aging Neurosci"},{"issue":"10","key":"1991_CR117","doi-asserted-by":"publisher","first-page":"1154","DOI":"10.1038\/nm.3951","volume":"21","author":"SW Min","year":"2015","unstructured":"Min SW, Chen X, Tracy TE, Li Y, Zhou Y, Wang C, Shirakawa K, Minami SS, Defensor E, Mok SA, Sohn PD, Schilling B, Cong X, Ellerby L, Gibson BW, Johnson J, Krogan N, Shamloo M, Gestwicki J, Masliah E, Verdin E, Gan L (2015) Critical role of acetylation in tau-mediated neurodegeneration and cognitive deficits. Nat Med 21(10):1154\u20131162. https:\/\/doi.org\/10.1038\/nm.3951","journal-title":"Nat Med"},{"issue":"2","key":"1991_CR118","doi-asserted-by":"publisher","first-page":"296","DOI":"10.1016\/j.neuron.2014.12.032","volume":"85","author":"A Montagne","year":"2015","unstructured":"Montagne A, Barnes SR, Sweeney MD, Halliday MR, Sagare AP, Zhao Z, Toga AW, Jacobs RE, Liu CY, Amezcua L, Harrington MG, Chui HC, Law M, Zlokovic BV (2015) Blood-brain barrier breakdown in the aging human hippocampus. Neuron 85(2):296\u2013302. https:\/\/doi.org\/10.1016\/j.neuron.2014.12.032","journal-title":"Neuron"},{"issue":"6","key":"1991_CR119","doi-asserted-by":"publisher","first-page":"791","DOI":"10.1002\/mds.26562","volume":"31","author":"T Moors","year":"2016","unstructured":"Moors T, Paciotti S, Chiasserini D, Calabresi P, Parnetti L, Beccari T, van de Berg WD (2016) Lysosomal dysfunction and alpha-synuclein aggregation in Parkinson\u2019s disease: diagnostic links. Mov Disord 31(6):791\u2013801. https:\/\/doi.org\/10.1002\/mds.26562","journal-title":"Mov Disord"},{"issue":"4","key":"1991_CR120","doi-asserted-by":"publisher","first-page":"240","DOI":"10.1038\/nrn3200","volume":"13","author":"JH Morrison","year":"2012","unstructured":"Morrison JH, Baxter MG (2012) The ageing cortical synapse: hallmarks and implications for cognitive decline. Nat Rev Neurosci 13(4):240\u2013250. https:\/\/doi.org\/10.1038\/nrn3200","journal-title":"Nat Rev Neurosci"},{"issue":"4","key":"1991_CR121","doi-asserted-by":"publisher","first-page":"486","DOI":"10.1007\/s00259-005-1762-7","volume":"32","author":"L Mosconi","year":"2005","unstructured":"Mosconi L (2005) Brain glucose metabolism in the early and specific diagnosis of Alzheimer\u2019s disease. FDG-PET studies in MCI and AD. Eur J Nucl Med Mol Imaging 32(4):486\u2013510. https:\/\/doi.org\/10.1007\/s00259-005-1762-7","journal-title":"Eur J Nucl Med Mol Imaging"},{"issue":"4","key":"1991_CR122","doi-asserted-by":"publisher","first-page":"468","DOI":"10.1016\/j.jalz.2013.06.005","volume":"10","author":"M Nakanishi","year":"2014","unstructured":"Nakanishi M, Nakashima T (2014) Features of the Japanese national dementia strategy in comparison with international dementia policies: How should a national dementia policy interact with the public health-and social-care systems? Alzheimer\u2019s Dementia 10(4):468\u2013476","journal-title":"Alzheimer's Dementia"},{"issue":"4","key":"1991_CR123","doi-asserted-by":"publisher","first-page":"695","DOI":"10.1111\/j.1532-5415.2005.53221.x","volume":"53","author":"ZS Nasreddine","year":"2005","unstructured":"Nasreddine ZS, Phillips NA, B\u00e9dirian V, Charbonneau S, Whitehead V, Collin I, Cummings JL, Chertkow H (2005) The Montreal Cognitive Assessment, MoCA: a brief screening tool for mild cognitive impairment. J Am Geriatr Soc 53(4):695\u2013699","journal-title":"J Am Geriatr Soc"},{"issue":"1","key":"1991_CR124","doi-asserted-by":"publisher","first-page":"60","DOI":"10.3390\/pharmaceutics16010060","volume":"16","author":"M Neatu","year":"2023","unstructured":"Neatu M, Covaliu A, Ionita I, Jugurt A, Davidescu EI, Popescu BO (2023) Monoclonal antibody therapy in Alzheimer\u2019s disease. Pharmaceutics 16(1):60. https:\/\/doi.org\/10.3390\/pharmaceutics16010060","journal-title":"Pharmaceutics"},{"key":"1991_CR125","doi-asserted-by":"publisher","first-page":"355","DOI":"10.3389\/fnagi.2019.00355","volume":"11","author":"BJ Neth","year":"2020","unstructured":"Neth BJ, Graff-Radford J, Mielke MM, Przybelski SA, Lesnick TG, Schwarz CG, Reid RI, Senjem ML, Lowe VJ, Machulda MM (2020) Relationship between risk factors and brain reserve in late middle age: implications for cognitive aging. Front Aging Neurosci 11:355","journal-title":"Front Aging Neurosci"},{"issue":"1","key":"1991_CR126","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1111\/j.1365-2990.2012.01306.x","volume":"39","author":"DM Norden","year":"2013","unstructured":"Norden DM, Godbout J (2013) Microglia of the aged brain: primed to be activated and resistant to regulation. Neuropathol Appl Neurobiol 39(1):19\u201334","journal-title":"Neuropathol Appl Neurobiol"},{"issue":"2","key":"1991_CR127","doi-asserted-by":"publisher","first-page":"481","DOI":"10.3233\/JAD-180325","volume":"67","author":"P Oeckl","year":"2019","unstructured":"Oeckl P, Halbgebauer S, Anderl-Straub S, Steinacker P, Huss AM, Neugebauer H, von Arnim CA, Diehl-Schmid J, Grimmer T, Kornhuber J (2019) Glial fibrillary acidic protein in serum is increased in Alzheimer\u2019s disease and correlates with cognitive impairment. J Alzheimer\u2019s Dis 67(2):481\u2013488","journal-title":"J Alzheimer\u2019s Dis"},{"issue":"2","key":"1991_CR128","doi-asserted-by":"publisher","DOI":"10.1111\/acel.13296","volume":"20","author":"M Ogrodnik","year":"2021","unstructured":"Ogrodnik M, Evans SA, Fielder E, Victorelli S, Kruger P, Salmonowicz H, Weigand BM, Patel AD, Pirtskhalava T, Inman CL, Johnson KO, Dickinson SL, Rocha A, Schafer MJ, Zhu Y, Allison DB, von Zglinicki T, LeBrasseur NK, Tchkonia T, Neretti N, Passos JF, Kirkland JL et al (2021) Whole-body senescent cell clearance alleviates age-related brain inflammation and cognitive impairment in mice. Aging Cell 20(2):e13296. https:\/\/doi.org\/10.1111\/acel.13296","journal-title":"Aging Cell"},{"issue":"13","key":"1991_CR129","doi-asserted-by":"publisher","first-page":"1268","DOI":"10.1056\/NEJMoa0809335","volume":"361","author":"CW Olanow","year":"2009","unstructured":"Olanow CW, Rascol O, Hauser R, Feigin PD, Jankovic J, Lang A, Langston W, Melamed E, Poewe W, Stocchi F (2009) A double-blind, delayed-start trial of rasagiline in Parkinson\u2019s disease. N Engl J Med 361(13):1268\u20131278","journal-title":"N Engl J Med"},{"issue":"6265","key":"1991_CR130","doi-asserted-by":"publisher","first-page":"1214","DOI":"10.1126\/science.aac8469","volume":"350","author":"PW O'Toole","year":"2015","unstructured":"O\u2019Toole PW, Jeffery IB (2015) Gut microbiota and aging. Science 350(6265):1214\u20131215. https:\/\/doi.org\/10.1126\/science.aac8469","journal-title":"Science"},{"issue":"4","key":"1991_CR131","doi-asserted-by":"publisher","first-page":"1096","DOI":"10.1038\/s41591-024-02886-y","volume":"30","author":"Pagano G, Taylor KI, Anzures Cabrera J, Simuni T, Marek K, Postuma RB, Pavese N, Stocchi F, Brockmann K, Svoboda H, Trundell D, Monnet A, Doody R, Fontoura P, Kerchner GA, Brundin P, Nikolcheva T, Bonni A, Investigators P, Prasinezumab Study G","year":"2024","unstructured":"Pagano G, Taylor KI, Anzures Cabrera J, Simuni T, Marek K, Postuma RB, Pavese N, Stocchi F, Brockmann K, Svoboda H, Trundell D, Monnet A, Doody R, Fontoura P, Kerchner GA, Brundin P, Nikolcheva T, Bonni A, Investigators P, Prasinezumab Study G (2024) Prasinezumab slows motor progression in rapidly progressing early-stage Parkinson\u2019s disease. Nat Med 30(4):1096\u20131103. https:\/\/doi.org\/10.1038\/s41591-024-02886-y","journal-title":"Nat Med"},{"issue":"8","key":"1991_CR132","doi-asserted-by":"publisher","first-page":"772","DOI":"10.1001\/jama.2020.12134","volume":"324","author":"S Palmqvist","year":"2020","unstructured":"Palmqvist S, Janelidze S, Quiroz YT, Zetterberg H, Lopera F, Stomrud E, Su Y, Chen Y, Serrano GE, Leuzy A, Mattsson-Carlgren N, Strandberg O, Smith R, Villegas A, Sepulveda-Falla D, Chai X, Proctor NK, Beach TG, Blennow K, Hansson O (2020) Discriminative accuracy of plasma phospho-tau217 for Alzheimer disease vs other neurodegenerative disorders. JAMA 324(8):772\u2013781. https:\/\/doi.org\/10.1001\/jama.2020.12134","journal-title":"JAMA"},{"key":"1991_CR133","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1111\/j.1749-6632.1991.tb00191.x","volume":"640","author":"WD Parker Jr.","year":"1991","unstructured":"Parker WD Jr. (1991) Cytochrome oxidase deficiency in Alzheimer\u2019s disease. Ann N Y Acad Sci 640:59\u201364. https:\/\/doi.org\/10.1111\/j.1749-6632.1991.tb00191.x","journal-title":"Ann N Y Acad Sci"},{"issue":"6","key":"1991_CR134","doi-asserted-by":"publisher","first-page":"1138","DOI":"10.1177\/0271678X18771250","volume":"39","author":"S Paul","year":"2019","unstructured":"Paul S, Gallagher E, Liow JS, Mabins S, Henry K, Zoghbi SS, Gunn RN, Kreisl WC, Richards EM, Zanotti-Fregonara P, Morse CL, Hong J, Kowalski A, Pike VW, Innis RB, Fujita M (2019) Building a database for brain 18 kDa translocator protein imaged using [(11)C]PBR28 in healthy subjects. J Cereb Blood Flow Metab 39(6):1138\u20131147. https:\/\/doi.org\/10.1177\/0271678X18771250","journal-title":"J Cereb Blood Flow Metab"},{"issue":"5979","key":"1991_CR135","doi-asserted-by":"publisher","first-page":"753","DOI":"10.1126\/science.1186088","volume":"328","author":"S Peleg","year":"2010","unstructured":"Peleg S, Sananbenesi F, Zovoilis A, Burkhardt S, Bahari-Javan S, Agis-Balboa RC, Cota P, Wittnam JL, Gogol-Doering A, Opitz L (2010) Altered histone acetylation is associated with age-dependent memory impairment in mice. Science 328(5979):753\u2013756","journal-title":"Science"},{"issue":"2","key":"1991_CR136","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1016\/j.neuron.2014.12.007","volume":"85","author":"AM Pickrell","year":"2015","unstructured":"Pickrell AM, Youle RJ (2015) The roles of PINK1, parkin, and mitochondrial fidelity in Parkinson\u2019s disease. Neuron 85(2):257\u2013273. https:\/\/doi.org\/10.1016\/j.neuron.2014.12.007","journal-title":"Neuron"},{"issue":"1","key":"1991_CR137","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/nrdp.2017.13","volume":"3","author":"W Poewe","year":"2017","unstructured":"Poewe W, Seppi K, Tanner CM, Halliday GM, Brundin P, Volkmann J, Schrag A-E, Lang AE (2017) Parkinson disease. Nat Rev Dis Primers 3(1):1\u201321","journal-title":"Nat Rev Dis Primers"},{"issue":"5","key":"1991_CR138","doi-asserted-by":"publisher","first-page":"1259","DOI":"10.1159\/000502961","volume":"44","author":"PY-K Poon","year":"2019","unstructured":"Poon PY-K, Ng JK-C, Fung WW-S, Chow K-M, Kwan BC-H, Li PK-T, Szeto C-C (2019) Relationship between plasma endocan level and clinical outcome of Chinese peritoneal dialysis patients. Kidney Blood Press Res 44(5):1259\u20131270","journal-title":"Kidney Blood Press Res"},{"issue":"12","key":"1991_CR139","doi-asserted-by":"publisher","first-page":"4183","DOI":"10.1523\/JNEUROSCI.21-12-04183.2001","volume":"21","author":"D Pratico","year":"2001","unstructured":"Pratico D, Uryu K, Leight S, Trojanoswki JQ, Lee VM (2001) Increased lipid peroxidation precedes amyloid plaque formation in an animal model of Alzheimer amyloidosis. J Neurosci 21(12):4183\u20134187. https:\/\/doi.org\/10.1523\/JNEUROSCI.21-12-04183.2001","journal-title":"J Neurosci"},{"key":"1991_CR140","unstructured":"Prince M, Wimo A, Guerchet M, Ali GC, Wu YT, Prina M (2015) World Alzheimer Report 2015. The Global Impact of Dementia: an analysis of prevalence, incidence, cost and trends Alzheimer's Disease International]."},{"key":"1991_CR141","doi-asserted-by":"publisher","DOI":"10.1002\/ana.25634","author":"S Prins","year":"2020","unstructured":"Prins S, Zhuparris A, Groeneveld GJ (2020) Usefulness of plasma amyloid as a prescreener for the earliest Alzheimer pathological changes depends on the study population. Ann Neurol. https:\/\/doi.org\/10.1002\/ana.25634","journal-title":"Ann Neurol"},{"issue":"6301","key":"1991_CR142","doi-asserted-by":"publisher","first-page":"777","DOI":"10.1126\/science.aag2590","volume":"353","author":"RM Ransohoff","year":"2016","unstructured":"Ransohoff RM (2016) How neuroinflammation contributes to neurodegeneration. Science 353(6301):777\u2013783","journal-title":"Science"},{"issue":"1","key":"1991_CR143","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/948976","volume":"2013","author":"KS Rawji","year":"2013","unstructured":"Rawji KS, Yong VW (2013) The benefits and detriments of macrophages\/microglia in models of multiple sclerosis. Clin Dev Immunol 2013(1):948976. https:\/\/doi.org\/10.1155\/2013\/948976","journal-title":"Clin Dev Immunol"},{"issue":"14","key":"1991_CR144","doi-asserted-by":"publisher","first-page":"1333","DOI":"10.1056\/NEJMoa013128","volume":"348","author":"Reisberg B, Doody R, Stoffler A, Schmitt F, Ferris S, Mobius HJ, Memantine Study G","year":"2003","unstructured":"Reisberg B, Doody R, Stoffler A, Schmitt F, Ferris S, Mobius HJ, Memantine Study G (2003) Memantine in moderate-to-severe Alzheimer\u2019s disease. N Engl J Med 348(14):1333\u20131341. https:\/\/doi.org\/10.1056\/NEJMoa013128","journal-title":"N Engl J Med"},{"issue":"12","key":"1991_CR145","doi-asserted-by":"publisher","first-page":"1119","DOI":"10.1056\/NEJMoa1707914","volume":"377","author":"Ridker PM, Everett BM, Thuren T, MacFadyen JG, Chang WH, Ballantyne C, Fonseca F, Nicolau J, Koenig W, Anker SD, Kastelein JJP, Cornel JH, Pais P, Pella D, Genest J, Cifkova R, Lorenzatti A, Forster T, Kobalava Z, Group CT","year":"2017","unstructured":"Ridker PM, Everett BM, Thuren T, MacFadyen JG, Chang WH, Ballantyne C, Fonseca F, Nicolau J, Koenig W, Anker SD, Kastelein JJP, Cornel JH, Pais P, Pella D, Genest J, Cifkova R, Lorenzatti A, Forster T, Kobalava Z, Group CT (2017) Antiinflammatory therapy with Canakinumab for atherosclerotic disease. N Engl J Med 377(12):1119\u20131131. https:\/\/doi.org\/10.1056\/NEJMoa1707914","journal-title":"N Engl J Med"},{"key":"1991_CR146","doi-asserted-by":"crossref","unstructured":"Ristori S, Bertoni G, Bientinesi E, Monti D (2025) The role of nutraceuticals and functional foods in mitigating cellular senescence and its related aspects: a key strategy for delaying or preventing aging and neurodegenerative disorders","DOI":"10.20944\/preprints202504.0821.v1"},{"issue":"1","key":"1991_CR147","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1016\/S1474-4422(10)70245-3","volume":"10","author":"CA Ross","year":"2011","unstructured":"Ross CA, Tabrizi SJ (2011) Huntington\u2019s disease: from molecular pathogenesis to clinical treatment. Lancet Neurol 10(1):83\u201398. https:\/\/doi.org\/10.1016\/S1474-4422(10)70245-3","journal-title":"Lancet Neurol"},{"issue":"4","key":"1991_CR148","doi-asserted-by":"publisher","first-page":"855","DOI":"10.1016\/j.ncl.2015.07.012","volume":"33","author":"S Saberi","year":"2015","unstructured":"Saberi S, Stauffer JE, Schulte DJ, Ravits J (2015) Neuropathology of amyotrophic lateral sclerosis and its variants. Neurol Clin 33(4):855\u2013876. https:\/\/doi.org\/10.1016\/j.ncl.2015.07.012","journal-title":"Neurol Clin"},{"issue":"1","key":"1991_CR149","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1111\/acel.12020","volume":"12","author":"JS Salvi","year":"2013","unstructured":"Salvi JS, Chan JN, Pettigrew C, Liu TT, Wu JD, Mekhail K (2013) Enforcement of a lifespan-sustaining distribution of Sir2 between telomeres, mating-type loci, and rDNA repeats by Rif1. Aging Cell 12(1):67\u201375","journal-title":"Aging Cell"},{"key":"1991_CR150","doi-asserted-by":"publisher","DOI":"10.1113\/JP286599","author":"P Samuel","year":"2025","unstructured":"Samuel P, Andrew J, Svetlana M (2025) The causative role of amyloidosis in the cardiac complications of Alzheimer\u2019s disease: a comprehensive systematic review. J Physiol. https:\/\/doi.org\/10.1113\/JP286599","journal-title":"J Physiol"},{"issue":"5","key":"1991_CR151","doi-asserted-by":"publisher","first-page":"971","DOI":"10.1016\/j.neuron.2016.01.028","volume":"89","author":"M Scholl","year":"2016","unstructured":"Scholl M, Lockhart SN, Schonhaut DR, O\u2019Neil JP, Janabi M, Ossenkoppele R, Baker SL, Vogel JW, Faria J, Schwimmer HD, Rabinovici GD, Jagust WJ (2016) PET imaging of Tau deposition in the aging human brain. Neuron 89(5):971\u2013982. https:\/\/doi.org\/10.1016\/j.neuron.2016.01.028","journal-title":"Neuron"},{"issue":"6","key":"1991_CR152","doi-asserted-by":"publisher","first-page":"595","DOI":"10.15252\/emmm.201606210","volume":"8","author":"DJ Selkoe","year":"2016","unstructured":"Selkoe DJ, Hardy J (2016) The amyloid hypothesis of Alzheimer\u2019s disease at 25 years. EMBO Mol Med 8(6):595\u2013608","journal-title":"EMBO Mol Med"},{"issue":"5","key":"1991_CR153","doi-asserted-by":"publisher","first-page":"283","DOI":"10.1038\/nrm3565","volume":"14","author":"C Settembre","year":"2013","unstructured":"Settembre C, Fraldi A, Medina DL, Ballabio A (2013) Signals from the lysosome: a control centre for cellular clearance and energy metabolism. Nat Rev Mol Cell Biol 14(5):283\u2013296. https:\/\/doi.org\/10.1038\/nrm3565","journal-title":"Nat Rev Mol Cell Biol"},{"issue":"7","key":"1991_CR154","doi-asserted-by":"publisher","first-page":"1099","DOI":"10.1038\/s41593-019-0423-2","volume":"22","author":"SH Shahmoradian","year":"2019","unstructured":"Shahmoradian SH, Lewis AJ, Genoud C, Hench J, Moors TE, Navarro PP, Castano-Diez D, Schweighauser G, Graff-Meyer A, Goldie KN, Sutterlin R, Huisman E, Ingrassia A, Gier Y, Rozemuller AJM, Wang J, Paepe A, Erny J, Staempfli A, Gier Yd, Paepe AD, Hoernschemeyer J, Gro\u00dfer\u00fcschkamp F, Niedieker D, El-Mashtoly SF, Quadri M, Van IJcken WFJ, Bonifati V, Gerwert K, Bohrmann B, Frank S, Britschgi M, Stahlberg H, de Van Berg WDJ, Lauer ME (2019) Lewy pathology in Parkinson\u2019s disease consists of crowded organelles and lipid membranes. Nat Neurosci 22(7):1099\u20131109. https:\/\/doi.org\/10.1038\/s41593-019-0423-2","journal-title":"Nat Neurosci"},{"issue":"2","key":"1991_CR155","doi-asserted-by":"publisher","first-page":"218","DOI":"10.1002\/mus.26740","volume":"61","author":"J Shefner","year":"2020","unstructured":"Shefner J, Heiman-Patterson T, Pioro EP, Wiedau-Pazos M, Liu S, Zhang J, Agnese W, Apple S (2020) Long-term edaravone efficacy in amyotrophic lateral sclerosis: post-hoc analyses of study 19 (MCI186-19). Muscle Nerve 61(2):218\u2013221","journal-title":"Muscle Nerve"},{"issue":"12","key":"1991_CR156","doi-asserted-by":"publisher","first-page":"1591","DOI":"10.1038\/s43587-023-00523-w","volume":"3","author":"M Shulman","year":"2023","unstructured":"Shulman M, Kong J, O\u2019Gorman J, Ratti E, Rajagovindan R, Viollet L, Huang E, Sharma S, Racine AM, Czerkowicz J, Graham D, Li Y, Hering H, Haeberlein SB (2023) TANGO: a placebo-controlled randomized phase 2 study of efficacy and safety of the anti-tau monoclonal antibody gosuranemab in early Alzheimer\u2019s disease. Nat Aging 3(12):1591\u20131601. https:\/\/doi.org\/10.1038\/s43587-023-00523-w","journal-title":"Nat Aging"},{"issue":"12","key":"1991_CR157","doi-asserted-by":"publisher","first-page":"1569","DOI":"10.1002\/mds.25963","volume":"29","author":"C Sidiropoulos","year":"2014","unstructured":"Sidiropoulos C, Moro E (2014) Low-frequency subthalamic nucleus stimulation in Parkinson\u2019s disease. Mov Disord 29(12):1569. https:\/\/doi.org\/10.1002\/mds.25963","journal-title":"Mov Disord"},{"issue":"11","key":"1991_CR158","doi-asserted-by":"publisher","first-page":"986","DOI":"10.1016\/S1474-4422(12)70190-4","volume":"11","author":"E Sidransky","year":"2012","unstructured":"Sidransky E, Lopez G (2012) The link between the GBA gene and parkinsonism. Lancet Neurol 11(11):986\u2013998","journal-title":"Lancet Neurol"},{"issue":"6","key":"1991_CR159","doi-asserted-by":"publisher","first-page":"486","DOI":"10.1212\/WNL.0000000000000665","volume":"83","author":"A Singh-Manoux","year":"2014","unstructured":"Singh-Manoux A, Dugravot A, Brunner E, Kumari M, Shipley M, Elbaz A, Kivimaki M (2014) Interleukin-6 and C-reactive protein as predictors of cognitive decline in late midlife. Neurology 83(6):486\u2013493","journal-title":"Neurology"},{"issue":"3","key":"1991_CR160","doi-asserted-by":"publisher","first-page":"266","DOI":"10.1016\/j.jagp.2017.10.010","volume":"26","author":"GW Small","year":"2018","unstructured":"Small GW, Siddarth P, Li Z, Miller KJ, Ercoli L, Emerson ND, Martinez J, Wong K-P, Liu J, Merrill DA (2018) Memory and brain amyloid and tau effects of a bioavailable form of curcumin in non-demented adults: a double-blind, placebo-controlled 18-month trial. Am J Geriatr Psychiatry 26(3):266\u2013277","journal-title":"Am J Geriatr Psychiatry"},{"issue":"7696","key":"1991_CR161","doi-asserted-by":"publisher","first-page":"377","DOI":"10.1038\/nature25975","volume":"555","author":"SF Sorrells","year":"2018","unstructured":"Sorrells SF, Paredes MF, Cebrian-Silla A, Sandoval K, Qi D, Kelley KW, James D, Mayer S, Chang J, Auguste KI, Chang EF, Gutierrez AJ, Kriegstein AR, Mathern GW, Oldham MC, Huang EJ, Garcia-Verdugo JM, Yang Z, Alvarez-Buylla A (2018) Human hippocampal neurogenesis drops sharply in children to undetectable levels in adults. Nature 555(7696):377\u2013381. https:\/\/doi.org\/10.1038\/nature25975","journal-title":"Nature"},{"issue":"10","key":"1991_CR162","doi-asserted-by":"publisher","first-page":"1332","DOI":"10.1038\/s41593-018-0235-9","volume":"21","author":"C Soto","year":"2018","unstructured":"Soto C, Pritzkow S (2018) Protein misfolding, aggregation, and conformational strains in neurodegenerative diseases. Nat Neurosci 21(10):1332\u20131340. https:\/\/doi.org\/10.1038\/s41593-018-0235-9","journal-title":"Nat Neurosci"},{"issue":"2","key":"1991_CR163","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a009399","volume":"2","author":"L Stefanis","year":"2012","unstructured":"Stefanis L (2012) Alpha-Synuclein in Parkinson\u2019s disease. Cold Spring Harb Perspect Med 2(2):a009399. https:\/\/doi.org\/10.1101\/cshperspect.a009399","journal-title":"Cold Spring Harb Perspect Med"},{"issue":"11\u201312","key":"1991_CR164","doi-asserted-by":"publisher","first-page":"2021","DOI":"10.1089\/ars.2006.8.2021","volume":"8","author":"R Sultana","year":"2006","unstructured":"Sultana R, Perluigi M, Butterfield DA (2006) Protein oxidation and lipid peroxidation in brain of subjects with Alzheimer\u2019s disease: insights into mechanism of neurodegeneration from redox proteomics. Antioxid Redox Signal 8(11\u201312):2021\u20132037","journal-title":"Antioxid Redox Signal"},{"issue":"5","key":"1991_CR165","doi-asserted-by":"publisher","first-page":"654","DOI":"10.1016\/j.molcel.2016.01.028","volume":"61","author":"N Sun","year":"2016","unstructured":"Sun N, Youle RJ, Finkel T (2016) The mitochondrial basis of aging. Mol Cell 61(5):654\u2013666. https:\/\/doi.org\/10.1016\/j.molcel.2016.01.028","journal-title":"Mol Cell"},{"issue":"3","key":"1991_CR166","doi-asserted-by":"publisher","DOI":"10.3892\/ijmm.2025.5580","volume":"56","author":"Y Sun","year":"2025","unstructured":"Sun Y, Wei K, Liao X, Wang J, Gao L, Pang B (2025) Lipid metabolism in microglia: emerging mechanisms and therapeutic opportunities for neurodegenerative diseases (Review). Int J Mol Med 56(3):139. https:\/\/doi.org\/10.3892\/ijmm.2025.5580","journal-title":"Int J Mol Med"},{"key":"1991_CR167","doi-asserted-by":"crossref","unstructured":"Sweeney MD, Zhao Z, Montagne A, Nelson AR, Zlokovic BV (2018) Blood-brain barrier: from physiology to disease and back. Physiol Rev","DOI":"10.1152\/physrev.00050.2017"},{"issue":"3","key":"1991_CR168","doi-asserted-by":"publisher","first-page":"1403","DOI":"10.3233\/JAD-170585","volume":"62","author":"RH Swerdlow","year":"2018","unstructured":"Swerdlow RH (2018) Mitochondria and mitochondrial cascades in Alzheimer\u2019s disease. J Alzheimers Dis 62(3):1403\u20131416. https:\/\/doi.org\/10.3233\/JAD-170585","journal-title":"J Alzheimers Dis"},{"issue":"1","key":"1991_CR169","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1016\/j.brainresrev.2008.07.007","volume":"59","author":"L Tapia-Arancibia","year":"2008","unstructured":"Tapia-Arancibia L, Aliaga E, Silhol M, Arancibia S (2008) New insights into brain BDNF function in normal aging and Alzheimer disease. Brain Res Rev 59(1):201\u2013220","journal-title":"Brain Res Rev"},{"issue":"5","key":"1991_CR170","doi-asserted-by":"publisher","first-page":"595","DOI":"10.1111\/jnc.14234","volume":"144","author":"T Tarumi","year":"2018","unstructured":"Tarumi T, Zhang R (2018) Cerebral blood flow in normal aging adults: cardiovascular determinants, clinical implications, and aerobic fitness. J Neurochem 144(5):595\u2013608. https:\/\/doi.org\/10.1111\/jnc.14234","journal-title":"J Neurochem"},{"issue":"7628","key":"1991_CR171","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1038\/nature20413","volume":"539","author":"JP Taylor","year":"2016","unstructured":"Taylor JP, Brown RH Jr, Cleveland DW (2016) Decoding ALS: from genes to mechanism. Nature 539(7628):197\u2013206","journal-title":"Nature"},{"issue":"24","key":"1991_CR172","doi-asserted-by":"publisher","DOI":"10.3390\/ijms232415674","volume":"23","author":"S Terracina","year":"2022","unstructured":"Terracina S, Petrella C, Francati S, Lucarelli M, Barbato C, Minni A, Ralli M, Greco A, Tarani L, Fiore M, Ferraguti G (2022) Antioxidant intervention to improve cognition in the aging brain: the example of Hydroxytyrosol and Resveratrol. Int J Mol Sci 23(24):15674. https:\/\/doi.org\/10.3390\/ijms232415674","journal-title":"Int J Mol Sci"},{"issue":"1","key":"1991_CR173","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1056\/NEJMoa2212948","volume":"388","author":"CH Van Dyck","year":"2023","unstructured":"Van Dyck CH, Swanson CJ, Aisen P, Bateman RJ, Chen C, Gee M, Kanekiyo M, Li D, Reyderman L, Cohen S (2023) Lecanemab in early Alzheimer\u2019s disease. N Engl J Med 388(1):9\u201321","journal-title":"N Engl J Med"},{"key":"1991_CR174","doi-asserted-by":"publisher","first-page":"117","DOI":"10.3389\/fnagi.2020.00117","volume":"12","author":"S Walker","year":"2020","unstructured":"Walker S, Monto S, Piirainen JM, Avela J, Tarkka IM, Parviainen TM, Piitulainen H (2020) Older age increases the amplitude of muscle stretch-induced cortical beta-band suppression but does not affect rebound strength. Front Aging Neurosci 12:117","journal-title":"Front Aging Neurosci"},{"key":"1991_CR175","doi-asserted-by":"publisher","first-page":"1288894","DOI":"10.3389\/fphar.2023.1288894","volume":"14","author":"D Wang","year":"2023","unstructured":"Wang D, Qu S, Zhang Z, Tan L, Chen X, Zhong HJ, Chong CM (2023) Strategies targeting endoplasmic reticulum stress to improve Parkinson\u2019s disease. Front Pharmacol 14:1288894. https:\/\/doi.org\/10.3389\/fphar.2023.1288894","journal-title":"Front Pharmacol"},{"issue":"3","key":"1991_CR176","doi-asserted-by":"publisher","first-page":"48","DOI":"10.3892\/ijmm.2025.5489","volume":"55","author":"H Wang","year":"2025","unstructured":"Wang H, Ma L, Su W, Liu Y, Xie N, Liu J (2025) Nlrp3 inflammasome in health and disease (review). Int J Mol Med 55(3):48. https:\/\/doi.org\/10.3892\/ijmm.2025.5489","journal-title":"Int J Mol Med"},{"issue":"6379","key":"1991_CR177","doi-asserted-by":"publisher","first-page":"988","DOI":"10.1126\/science.aar5439","volume":"359","author":"KJ Willis","year":"2018","unstructured":"Willis KJ, Jeffers ES, Tovar C (2018) What makes a terrestrial ecosystem resilient? Science 359(6379):988\u2013989","journal-title":"Science"},{"issue":"1","key":"1991_CR178","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.jalz.2016.07.150","volume":"13","author":"A Wimo","year":"2017","unstructured":"Wimo A, Guerchet M, Ali GC, Wu YT, Prina AM, Winblad B, Jonsson L, Liu Z, Prince M (2017) The worldwide costs of dementia 2015 and comparisons with 2010. Alzheimers Dement 13(1):1\u20137. https:\/\/doi.org\/10.1016\/j.jalz.2016.07.150","journal-title":"Alzheimers Dement"},{"issue":"10","key":"1991_CR179","doi-asserted-by":"publisher","first-page":"1696","DOI":"10.1038\/s41593-019-0491-3","volume":"22","author":"M Ximerakis","year":"2019","unstructured":"Ximerakis M, Lipnick SL, Innes BT, Simmons SK, Adiconis X, Dionne D, Mayweather BA, Nguyen L, Niziolek Z, Ozek C, Butty VL, Isserlin R, Buchanan SM, Levine SS, Regev A, Bader GD, Levin JZ, Rubin LL (2019) Single-cell transcriptomic profiling of the aging mouse brain. Nat Neurosci 22(10):1696\u20131708. https:\/\/doi.org\/10.1038\/s41593-019-0491-3","journal-title":"Nat Neurosci"},{"issue":"6","key":"1991_CR180","doi-asserted-by":"publisher","first-page":"713","DOI":"10.1016\/j.stem.2013.04.003","volume":"12","author":"YM Yang","year":"2013","unstructured":"Yang YM, Gupta SK, Kim KJ, Powers BE, Cerqueira A, Wainger BJ, Ngo HD, Rosowski KA, Schein PA, Ackeifi CA (2013) A small molecule screen in stem-cell-derived motor neurons identifies a kinase inhibitor as a candidate therapeutic for ALS. Cell Stem Cell 12(6):713\u2013726","journal-title":"Cell Stem Cell"},{"issue":"6098","key":"1991_CR181","doi-asserted-by":"publisher","first-page":"1062","DOI":"10.1126\/science.1219855","volume":"337","author":"RJ Youle","year":"2012","unstructured":"Youle RJ, van der Bliek AM (2012) Mitochondrial fission, fusion, and stress. Science 337(6098):1062\u20131065. https:\/\/doi.org\/10.1126\/science.1219855","journal-title":"Science"},{"issue":"5","key":"1991_CR182","doi-asserted-by":"publisher","first-page":"1423","DOI":"10.1016\/S0002-9440(10)65396-5","volume":"154","author":"J Zhang","year":"1999","unstructured":"Zhang J, Perry G, Smith MA, Robertson D, Olson SJ, Graham DG, Montine TJ (1999) Parkinson\u2019s disease is associated with oxidative damage to cytoplasmic DNA and RNA in substantia nigra neurons. Am J Pathol 154(5):1423\u20131429","journal-title":"Am J Pathol"},{"issue":"5","key":"1991_CR183","doi-asserted-by":"publisher","first-page":"719","DOI":"10.1038\/s41593-019-0372-9","volume":"22","author":"P Zhang","year":"2019","unstructured":"Zhang P, Kishimoto Y, Grammatikakis I, Gottimukkala K, Cutler RG, Zhang S, Abdelmohsen K, Bohr VA, Misra Sen J, Gorospe M, Mattson MP (2019) Senolytic therapy alleviates Abeta-associated oligodendrocyte progenitor cell senescence and cognitive deficits in an Alzheimer\u2019s disease model. Nat Neurosci 22(5):719\u2013728. https:\/\/doi.org\/10.1038\/s41593-019-0372-9","journal-title":"Nat Neurosci"},{"issue":"4","key":"1991_CR184","doi-asserted-by":"publisher","first-page":"644","DOI":"10.1111\/acel.12344","volume":"14","author":"Y Zhu","year":"2015","unstructured":"Zhu Y, Tchkonia T, Pirtskhalava T, Gower AC, Ding H, Giorgadze N, Palmer AK, Ikeno Y, Hubbard GB, Lenburg M (2015) The Achilles\u2019 heel of senescent cells: from transcriptome to senolytic drugs. Aging Cell 14(4):644\u2013658","journal-title":"Aging Cell"}],"container-title":["Inflammopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10787-025-01991-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10787-025-01991-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10787-025-01991-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,17]],"date-time":"2025-11-17T20:04:36Z","timestamp":1763409876000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10787-025-01991-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10,2]]},"references-count":183,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2025,11]]}},"alternative-id":["1991"],"URL":"https:\/\/doi.org\/10.1007\/s10787-025-01991-9","relation":{},"ISSN":["0925-4692","1568-5608"],"issn-type":[{"value":"0925-4692","type":"print"},{"value":"1568-5608","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,10,2]]},"assertion":[{"value":"3 August 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 September 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 October 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"Not applicable.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}},{"value":"Not applicable.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to publish"}}]}}