{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T17:20:19Z","timestamp":1790961619631,"version":"4.1.0"},"reference-count":242,"publisher":"Springer Science and Business Media LLC","issue":"12","license":[{"start":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T00:00:00Z","timestamp":1761782400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T00:00:00Z","timestamp":1761782400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"Heliopolis University"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Inflammopharmacol"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Chronic pruritus, characterized by persistent itching, is a significant health issue that adversely affects individuals\u2019 quality of life, particularly in palliative care environments. Conventional treatments frequently do not yield sufficient relief and may lead to undesirable side effects, which has spurred interest in exploring alternative therapeutic options. A thorough literature search was conducted across several databases such as PubMed, Web of Science, Scopus, and EKB, with an emphasis on studies involving in vitro, animal models, and clinical trials utilizing terms like \u201cplant,\u201d \u201cextract,\u201d and \u201cpruritus.\u201d All studies were considered regardless of their publication date and were limited to English-language articles. This review highlights the promise of various medicinal plants, including chamomile,\n                    <jats:italic>Aloe vera<\/jats:italic>\n                    , calendula, curcumin, lavender, licorice, and peppermint, as adjunctive therapies for pruritus. These plants possess a range of pharmacological properties, such as anti-inflammatory, antioxidant, and skin-soothing effects, which are relevant to the complex nature of pruritus. Their favorable safety profiles and natural origins enhance their appeal in holistic and patient-centered care models.\n                  <\/jats:p>","DOI":"10.1007\/s10787-025-01999-1","type":"journal-article","created":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T05:53:43Z","timestamp":1761803623000},"page":"7079-7106","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Modulatory effects of bioactive natural compounds on pruritic pathways: mechanistic basis and therapeutic prospects"],"prefix":"10.1007","volume":"33","author":[{"given":"Wagih H.","family":"Marcus","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hassan A.","family":"Ruby","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amira E.","family":"Awwad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahrous H.","family":"Mahrous","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ebraheem","family":"Abouelwafa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed A. S.","family":"Badawy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Riham A.","family":"El-Shiekh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-8427-0583","authenticated-orcid":false,"given":"Eman S.","family":"Zaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahmoud Abdelmouti","family":"Mahmoud","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,10,30]]},"reference":[{"key":"1999_CR1","doi-asserted-by":"publisher","first-page":"440","DOI":"10.1038\/nri2782","volume":"10","author":"SN Abraham","year":"2010","unstructured":"Abraham SN, St. John AL (2010) Mast cell-orchestrated immunity to pathogens. Nat Rev Immunol 10:440\u2013452","journal-title":"Nat Rev Immunol"},{"key":"1999_CR2","doi-asserted-by":"publisher","first-page":"364","DOI":"10.1001\/jamadermatol.2020.5639","volume":"157","author":"BL Adler","year":"2021","unstructured":"Adler BL, DeLeo VA (2021) Allergic contact dermatitis. JAMA Dermatol 157:364\u2013364","journal-title":"JAMA Dermatol"},{"key":"1999_CR3","doi-asserted-by":"publisher","first-page":"94","DOI":"10.11648\/j.ajcem.20160404.11","volume":"4","author":"VL Agung","year":"2016","unstructured":"Agung VL et al (2016) Anti-inflammatory effect of aloe vera (l) burm, F. on COX-2 and histamine expression in mice skin exposed to UVB. Am J Clin Exp Med 4:94\u201397","journal-title":"Am J Clin Exp Med"},{"key":"1999_CR4","doi-asserted-by":"publisher","first-page":"539","DOI":"10.1007\/BF00558141","volume":"37","author":"A Ajayi","year":"1989","unstructured":"Ajayi A, Oluokun A, Sofowora O, Akinleye A, Ajayi A (1989) Epidemiology of antimalarial-induced pruritus in Africans. Eur J Clin Pharmacol 37:539\u2013540","journal-title":"Eur J Clin Pharmacol"},{"key":"1999_CR5","doi-asserted-by":"publisher","first-page":"199","DOI":"10.5897\/AJMR10.368","volume":"5","author":"N Akhtar","year":"2011","unstructured":"Akhtar N et al (2011) Evaluation of various functional skin parameters using a topical cream of Calendula officinalis extract. Afr J Pharm Pharmacol 5:199\u2013206","journal-title":"Afr J Pharm Pharmacol"},{"key":"1999_CR6","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1080\/10942912.2023.2293661","volume":"27","author":"W Akram","year":"2024","unstructured":"Akram W et al (2024) An updated comprehensive review of the therapeutic properties of chamomile (Matricaria chamomilla L.). Int J Food Prop 27:133\u2013164","journal-title":"Int J Food Prop"},{"key":"1999_CR7","doi-asserted-by":"publisher","first-page":"190","DOI":"10.1002\/iid3.153","volume":"5","author":"AA Alangari","year":"2017","unstructured":"Alangari AA et al (2017) Honey is potentially effective in the treatment of atopic dermatitis: clinical and mechanistic studies. Immun Inflamm Dis 5:190\u2013199","journal-title":"Immun Inflamm Dis"},{"key":"1999_CR8","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1159\/000058336","volume":"1","author":"SI Ale","year":"2002","unstructured":"Ale SI, Host\u00fdnek JJ, Maibach HI (2002) Menthol: a review of its sensitization potential. Exog Dermatol 1:74\u201380","journal-title":"Exog Dermatol"},{"key":"1999_CR9","first-page":"1073","volume":"11","author":"MA Amjadi","year":"2012","unstructured":"Amjadi MA, Mojab F, Kamranpour SB (2012) The effect of peppermint oil on symptomatic treatment of pruritus in pregnant women. Iran J Pharm Res 11:1073","journal-title":"Iran J Pharm Res"},{"key":"1999_CR10","doi-asserted-by":"publisher","first-page":"596","DOI":"10.1111\/ced.13114","volume":"42","author":"HH Andersen","year":"2017","unstructured":"Andersen HH, Arendt-Nielsen L, Elberling J (2017) Topical capsaicin 8% for the treatment of neuropathic itch conditions. Clin Exp Dermatol 42:596\u2013598","journal-title":"Clin Exp Dermatol"},{"key":"1999_CR11","doi-asserted-by":"publisher","first-page":"283634","DOI":"10.1155\/2015\/283634","volume":"2015","author":"E Antiga","year":"2015","unstructured":"Antiga E, Bonciolini V, Volpi W, Del Bianco E, Caproni M (2015) Oral curcumin (Meriva) is effective as an adjuvant treatment and is able to reduce IL-22 serum levels in patients with psoriasis vulgaris. BioMed Res Int 2015:283634","journal-title":"BioMed Res Int"},{"key":"1999_CR12","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1111\/ijd.14678","volume":"59","author":"M Anzelc","year":"2020","unstructured":"Anzelc M, Burkhart CG (2020) Pain and pruritus: a study of their similarities and differences. Int J Dermatol 59:159\u2013164","journal-title":"Int J Dermatol"},{"key":"1999_CR13","doi-asserted-by":"publisher","first-page":"39","DOI":"10.13181\/mji.oa.204467","volume":"30","author":"FR Asih","year":"2021","unstructured":"Asih FR, Husin F, Suwarsa O, Fidrianny I, Hilmanto D (2021) A randomized controlled trial of combination of peppermint, lavender, and turmeric oil for antipruritic agent in pregnant women. Med J Indones 30:39\u201344","journal-title":"Med J Indones"},{"key":"1999_CR14","doi-asserted-by":"publisher","first-page":"2872","DOI":"10.2337\/db09-1606","volume":"59","author":"CA Aveleira","year":"2010","unstructured":"Aveleira CA, Lin C-M, Abcouwer SF, Ambrosio AF, Antonetti DA (2010) TNF-\u03b1 signals through PKC\u03b6\/NF-\u03baB to alter the tight junction complex and increase retinal endothelial cell permeability. Diabetes 59:2872\u20132882","journal-title":"Diabetes"},{"key":"1999_CR15","first-page":"112","volume":"16","author":"M Bakhshaee","year":"2017","unstructured":"Bakhshaee M et al (2017) Efficacy of supportive therapy of allergic rhinitis by stinging nettle (Urtica dioica) root extract: a randomized, double-blind, placebo-controlled, clinical trial. Iran J Pharm Res 16:112","journal-title":"Iran J Pharm Res"},{"key":"1999_CR16","doi-asserted-by":"publisher","first-page":"877","DOI":"10.1007\/s00210-023-02392-x","volume":"396","author":"GE-S Batiha","year":"2023","unstructured":"Batiha GE-S et al (2023) A review of the bioactive components and pharmacological properties of Lavandula species. Naunyn-Schmiedebergs Arch Pharmacol 396:877\u2013900","journal-title":"Naunyn-Schmiedebergs Arch Pharmacol"},{"key":"1999_CR17","doi-asserted-by":"publisher","first-page":"204","DOI":"10.1038\/nature05910","volume":"448","author":"DM Bautista","year":"2007","unstructured":"Bautista DM et al (2007) The menthol receptor TRPM8 is the principal detector of environmental cold. Nature 448:204\u2013208","journal-title":"Nature"},{"key":"1999_CR18","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1111\/cod.13247","volume":"81","author":"LJ Bingham","year":"2019","unstructured":"Bingham LJ, Tam MM, Palmer AM, Cahill JL, Nixon RL (2019) Contact allergy and allergic contact dermatitis caused by lavender: a retrospective study from an Australian clinic. Contact Dermatitis 81:37\u201342","journal-title":"Contact Dermatitis"},{"key":"1999_CR19","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1038\/nri2018","volume":"7","author":"SC Bischoff","year":"2007","unstructured":"Bischoff SC (2007) Role of mast cells in allergic and non-allergic immune responses: comparison of human and murine data. Nat Rev Immunol 7:93\u2013104","journal-title":"Nat Rev Immunol"},{"key":"1999_CR20","doi-asserted-by":"publisher","first-page":"3281","DOI":"10.3390\/molecules30153281","volume":"30","author":"N Bolatkyzy","year":"2025","unstructured":"Bolatkyzy N et al (2025) Medicinal plants for skin disorders: phytochemistry and pharmacological insights. Molecules 30:3281","journal-title":"Molecules"},{"key":"1999_CR21","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1080\/10590500600614303","volume":"24","author":"MD Boudreau","year":"2006","unstructured":"Boudreau MD, Beland FA (2006) An evaluation of the biological and toxicological properties of Aloe barbadensis (miller), Aloe vera. J Environ Sci Health C 24:103\u2013154","journal-title":"J Environ Sci Health C"},{"key":"1999_CR22","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1179\/1743291X14Y.0000000110","volume":"24","author":"F Brennan","year":"2016","unstructured":"Brennan F (2016) The pathophysiology of pruritus \u2013 a review for clinicians. Prog Palliat Care 24:133\u2013146","journal-title":"Prog Palliat Care"},{"key":"1999_CR23","doi-asserted-by":"publisher","first-page":"471","DOI":"10.1016\/j.molimm.2013.05.005","volume":"56","author":"MM Budai","year":"2013","unstructured":"Budai MM, Varga A, Milesz S, T\u0151zs\u00e9r J, Benk\u0151 S (2013) Aloe vera downregulates LPS-induced inflammatory cytokine production and expression of NLRP3 inflammasome in human macrophages. Mol Immunol 56:471\u2013479","journal-title":"Mol Immunol"},{"key":"1999_CR24","doi-asserted-by":"publisher","first-page":"805","DOI":"10.1111\/j.1398-9995.2010.01995.x","volume":"65","author":"J Buddenkotte","year":"2010","unstructured":"Buddenkotte J, Steinhoff M (2010) Pathophysiology and therapy of pruritus in allergic and atopic diseases. Allergy 65:805\u2013821","journal-title":"Allergy"},{"key":"1999_CR25","doi-asserted-by":"publisher","first-page":"1740","DOI":"10.3389\/fimmu.2020.01740","volume":"11","author":"T Buhl","year":"2020","unstructured":"Buhl T et al (2020) Protease-activated receptor-2 regulates neuro-epidermal communication in atopic dermatitis. Front Immunol 11:1740","journal-title":"Front Immunol"},{"key":"1999_CR26","doi-asserted-by":"publisher","first-page":"28556","DOI":"10.1074\/jbc.M111.256180","volume":"286","author":"C Buhrmann","year":"2011","unstructured":"Buhrmann C et al (2011) Curcumin modulates nuclear factor \u03baB (nf-\u03baB)-mediated inflammation in human tenocytes in vitro: role of the phosphatidylinositol 3-kinase\/Akt pathway. J Biol Chem 286:28556\u201328566","journal-title":"J Biol Chem"},{"key":"1999_CR27","doi-asserted-by":"publisher","first-page":"331","DOI":"10.1016\/j.cld.2012.03.010","volume":"16","author":"C Bunchorntavakul","year":"2012","unstructured":"Bunchorntavakul C, Reddy KR (2012) Pruritus in chronic cholestatic liver disease. Clin Liver Dis 16:331\u2013346","journal-title":"Clin Liver Dis"},{"key":"1999_CR28","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1016\/j.pharmthera.2004.11.008","volume":"106","author":"JB Calixto","year":"2005","unstructured":"Calixto JB, Kassuya CA, Andr\u00e9 E, Ferreira J (2005) Contribution of natural products to the discovery of the transient receptor potential (TRP) channels family and their functions. Pharmacol Ther 106:179\u2013208","journal-title":"Pharmacol Ther"},{"key":"1999_CR29","doi-asserted-by":"publisher","first-page":"1501","DOI":"10.1111\/exd.14034","volume":"28","author":"M Campion","year":"2019","unstructured":"Campion M et al (2019) Interleukin-4 and interleukin-13 evoke scratching behaviour in mice. Exp Dermatol 28:1501\u20131504","journal-title":"Exp Dermatol"},{"key":"1999_CR30","doi-asserted-by":"publisher","first-page":"1127","DOI":"10.1097\/00007611-196909000-00020","volume":"62","author":"C Caravati Jr","year":"1969","unstructured":"Caravati C Jr, Richardson D, Wood B, Cawley E (1969) Cutaneous manifestations of hyperthyroidism. South Med J 62:1127\u20131130","journal-title":"South Med J"},{"key":"1999_CR31","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1159\/000098131","volume":"13","author":"ML Castellani","year":"2007","unstructured":"Castellani ML et al (2007) Inhibitory effect of quercetin on tryptase and MCP-1 chemokine release, and histidine decarboxylase mRNA transcription by human mast cell-1 cell line. NeuroImmunoModulation 13:179\u2013186","journal-title":"NeuroImmunoModulation"},{"key":"1999_CR32","doi-asserted-by":"publisher","first-page":"301","DOI":"10.1002\/ptr.1103","volume":"16","author":"H Cavanagh","year":"2002","unstructured":"Cavanagh H, Wilkinson J (2002) Biological activities of lavender essential oil. Phytother Res 16:301\u2013308","journal-title":"Phytother Res"},{"key":"1999_CR33","first-page":"1116","volume":"9","author":"R Cerio","year":"2010","unstructured":"Cerio R et al (2010) Mechanism of action and clinical benefits of colloidal oatmeal for dermatologic practice. J Drug Dermatol 9:1116\u20131120","journal-title":"J Drug Dermatol"},{"issue":"448\u2013460","key":"1999_CR34","first-page":"e447","volume":"133","author":"F Cevikbas","year":"2014","unstructured":"Cevikbas F et al (2014) A sensory neuron\u2013expressed IL-31 receptor mediates T helper cell\u2013dependent itch: Involvement of TRPV1 and TRPA1. J Allergy Clin Immunol 133(448\u2013460):e447","journal-title":"J Allergy Clin Immunol"},{"key":"1999_CR35","doi-asserted-by":"publisher","first-page":"3052","DOI":"10.1038\/s41467-020-16859-5","volume":"11","author":"X-J Chen","year":"2020","unstructured":"Chen X-J, Sun Y-G (2020) Central circuit mechanisms of itch. Nat Commun 11:3052","journal-title":"Nat Commun"},{"key":"1999_CR36","doi-asserted-by":"publisher","DOI":"10.1002\/biof.2119","author":"YR Cho","year":"2024","unstructured":"Cho YR et al (2024) Propolis suppresses atopic dermatitis through targeting the MKK4 pathway. BioFactors. https:\/\/doi.org\/10.1002\/biof.2119","journal-title":"BioFactors"},{"key":"1999_CR37","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1016\/S1072-7515(99)00212-4","volume":"190","author":"F-F Chou","year":"2000","unstructured":"Chou F-F, Ho J-C, Huang S-C, Sheen-Chen S-M (2000) A study on pruritus after parathyroidectomy for secondary hyperparathyroidism. J Am Coll Surg 190:65\u201370","journal-title":"J Am Coll Surg"},{"key":"1999_CR38","doi-asserted-by":"publisher","first-page":"409","DOI":"10.5021\/ad.2018.30.4.409","volume":"30","author":"BY Chung","year":"2018","unstructured":"Chung BY, Park SY, Jung MJ, Kim HO, Park CW (2018) Effect of evening primrose oil on Korean patients with mild atopic dermatitis: a randomized, double-blinded, placebo-controlled clinical study. Ann Dermatol 30:409\u2013416","journal-title":"Ann Dermatol"},{"key":"1999_CR39","first-page":"102","volume":"3","author":"S Cioinac","year":"2016","unstructured":"Cioinac S (2016) Use of calendula cream balm to medicate the feet of diabetic patients: case series. Int J Nurs Sci 3:102\u2013112","journal-title":"Int J Nurs Sci"},{"key":"1999_CR40","doi-asserted-by":"publisher","DOI":"10.1016\/j.semnephrol.2015.06.009","author":"SA Combs","year":"2015","unstructured":"Combs SA, Teixeira JP, Germain MJ (2015) Pruritus in kidney disease. Semin Nephrol. https:\/\/doi.org\/10.1016\/j.semnephrol.2015.06.009","journal-title":"Semin Nephrol"},{"key":"1999_CR41","doi-asserted-by":"publisher","first-page":"568","DOI":"10.1016\/j.jid.2019.05.034","volume":"140","author":"FJ Dalgard","year":"2020","unstructured":"Dalgard FJ et al (2020) Itch and mental health in dermatological patients across Europe: a cross-sectional study in 13 countries. J Invest Dermatol 140:568\u2013573","journal-title":"J Invest Dermatol"},{"key":"1999_CR42","doi-asserted-by":"publisher","first-page":"10007","DOI":"10.1523\/JNEUROSCI.2862-07.2007","volume":"27","author":"S Davidson","year":"2007","unstructured":"Davidson S et al (2007) The itch-producing agents histamine and cowhage activate separate populations of primate spinothalamic tract neurons. J Neurosci 27:10007\u201310014","journal-title":"J Neurosci"},{"key":"1999_CR43","doi-asserted-by":"publisher","first-page":"752","DOI":"10.1038\/ni1084","volume":"5","author":"SR Dillon","year":"2004","unstructured":"Dillon SR et al (2004) Interleukin 31, a cytokine produced by activated T cells, induces dermatitis in mice. Nat Immunol 5:752\u2013760","journal-title":"Nat Immunol"},{"key":"1999_CR44","doi-asserted-by":"publisher","first-page":"439","DOI":"10.1016\/j.det.2006.06.002","volume":"24","author":"NC Dlova","year":"2006","unstructured":"Dlova NC, Mosam A (2006) Inflammatory noninfectious dermatoses of HIV. Dermatol Clin 24:439\u2013448","journal-title":"Dermatol Clin"},{"key":"1999_CR45","doi-asserted-by":"publisher","first-page":"482","DOI":"10.1016\/j.neuron.2018.03.023","volume":"98","author":"X Dong","year":"2018","unstructured":"Dong X, Dong X (2018) Peripheral and central mechanisms of itch. Neuron 98:482\u2013494","journal-title":"Neuron"},{"key":"1999_CR46","first-page":"101","volume":"27","author":"V Duran","year":"2005","unstructured":"Duran V et al (2005) Results of the clinical examination of an ointment with marigold (Calendula officinalis) extract in the treatment of venous leg ulcers. Int J Tissue React 27:101\u2013106","journal-title":"Int J Tissue React"},{"key":"1999_CR47","doi-asserted-by":"publisher","first-page":"479","DOI":"10.3390\/life12040479","volume":"12","author":"A El Mihyaoui","year":"2022","unstructured":"El Mihyaoui A et al (2022) Chamomile (Matricaria chamomilla L.): a review of ethnomedicinal use, phytochemistry and pharmacological uses. Life 12:479","journal-title":"Life"},{"key":"1999_CR48","doi-asserted-by":"publisher","first-page":"1183","DOI":"10.1007\/s10787-023-01178-0","volume":"31","author":"OY Elkhawaga","year":"2023","unstructured":"Elkhawaga OY, Ellety MM, Mofty SO, Ghanem MS, Mohamed AO (2023) Review of natural compounds for potential psoriasis treatment. Inflammopharmacology 31:1183\u20131198","journal-title":"Inflammopharmacology"},{"key":"1999_CR49","doi-asserted-by":"publisher","first-page":"438","DOI":"10.1016\/0190-9622(93)70208-B","volume":"29","author":"CN Ellis","year":"1993","unstructured":"Ellis CN et al (1993) A double-blind evaluation of topical capsaicin in pruritic psoriasis. J Am Acad Dermatol 29:438\u2013442","journal-title":"J Am Acad Dermatol"},{"key":"1999_CR50","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1080\/17425247.2020.1699054","volume":"17","author":"NS El-Salamouni","year":"2020","unstructured":"El-Salamouni NS et al (2020) Evaluation of chamomile oil and nanoemulgels as a promising treatment option for atopic dermatitis induced in rats. Expert Opin Drug Deliv 17:111\u2013122","journal-title":"Expert Opin Drug Deliv"},{"key":"1999_CR51","doi-asserted-by":"publisher","first-page":"930964","DOI":"10.3389\/fnmol.2022.930964","volume":"15","author":"A Fern\u00e1ndez-Carvajal","year":"2022","unstructured":"Fern\u00e1ndez-Carvajal A, Fern\u00e1ndez-Ballester G, Ferrer-Montiel A (2022) TRPV1 in chronic pruritus and pain: soft modulation as a therapeutic strategy. Front Mol Neurosci 15:930964","journal-title":"Front Mol Neurosci"},{"key":"1999_CR52","doi-asserted-by":"crossref","unstructured":"Follansbee, T., M. I. Carstens, and E. Carstens. 2021. Neural Processing of Pain and Itch Oxford Research Encyclopedia of Neuroscience.","DOI":"10.1093\/acrefore\/9780190264086.013.83"},{"key":"1999_CR53","doi-asserted-by":"publisher","first-page":"639","DOI":"10.1007\/s13555-019-00326-1","volume":"9","author":"KM Fourzali","year":"2019","unstructured":"Fourzali KM, Gil Y (2019) Management of itch in the elderly: a review. Dermatol Ther 9:639\u2013653","journal-title":"Dermatol Ther"},{"key":"1999_CR54","doi-asserted-by":"publisher","first-page":"5382","DOI":"10.3390\/ijms21155382","volume":"21","author":"M Furue","year":"2020","unstructured":"Furue M (2020) Regulation of filaggrin, loricrin, and involucrin by IL-4, IL-13, IL-17A, IL-22, AHR, and NRF2: pathogenic implications in atopic dermatitis. Int J Mol Sci 21:5382","journal-title":"Int J Mol Sci"},{"key":"1999_CR55","doi-asserted-by":"publisher","first-page":"693","DOI":"10.1038\/nm.2755","volume":"18","author":"SJ Galli","year":"2012","unstructured":"Galli SJ, Tsai M (2012) IgE and mast cells in allergic disease. Nat Med 18:693\u2013704","journal-title":"Nat Med"},{"issue":"45\u201359","key":"1999_CR56","first-page":"e49","volume":"101","author":"Z-R Gao","year":"2019","unstructured":"Gao Z-R et al (2019) Tac1-expressing neurons in the periaqueductal gray facilitate the itch-scratching cycle via descending regulation. Neuron 101(45\u201359):e49","journal-title":"Neuron"},{"key":"1999_CR57","doi-asserted-by":"publisher","first-page":"1383","DOI":"10.3389\/fimmu.2019.01383","volume":"10","author":"BF Gibbs","year":"2019","unstructured":"Gibbs BF, Patsinakidis N, Raap U (2019) Role of the pruritic cytokine IL-31 in autoimmune skin diseases. Front Immunol 10:1383","journal-title":"Front Immunol"},{"key":"1999_CR58","doi-asserted-by":"publisher","first-page":"1934","DOI":"10.1002\/1097-0142(19830515)51:10<1934::AID-CNCR2820511030>3.0.CO;2-R","volume":"51","author":"PG Gobbi","year":"1983","unstructured":"Gobbi PG, Attardo-Parrinello G, Lattanzio G, Rizzo SC, Ascari E (1983) Severe pruritus should be a B-symptom in Hodgkin\u2019s disease. Cancer 51:1934\u20131936","journal-title":"Cancer"},{"key":"1999_CR59","doi-asserted-by":"publisher","first-page":"3515","DOI":"10.3390\/plants13243515","volume":"13","author":"S Gon\u00e7alves","year":"2024","unstructured":"Gon\u00e7alves S et al (2024) Soothing the itch: the role of medicinal plants in alleviating pruritus in palliative care. Plants 13:3515","journal-title":"Plants"},{"key":"1999_CR60","doi-asserted-by":"publisher","first-page":"1341","DOI":"10.1007\/s11101-020-09680-x","volume":"19","author":"L Grauso","year":"2020","unstructured":"Grauso L, de Falco B, Lanzotti V, Motti R (2020) Stinging nettle, Urtica dioica L.: botanical, phytochemical and pharmacological overview. Phytochem Rev 19:1341\u20131377","journal-title":"Phytochem Rev"},{"key":"1999_CR61","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1083\/jcb.201603042","volume":"213","author":"D Green","year":"2016","unstructured":"Green D, Dong X (2016) The cell biology of acute itch. J Cell Biol 213:155\u2013161","journal-title":"J Cell Biol"},{"key":"1999_CR62","doi-asserted-by":"publisher","first-page":"1062","DOI":"10.1016\/j.bbrc.2018.01.122","volume":"496","author":"R Guo","year":"2018","unstructured":"Guo R et al (2018) Epigallocatechin-3-gallate attenuates acute and chronic psoriatic itch in mice: involvement of antioxidant, anti-inflammatory effects and suppression of ERK and Akt signaling pathways. Biochem Biophys Res Commun 496:1062\u20131068","journal-title":"Biochem Biophys Res Commun"},{"key":"1999_CR63","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1097\/00006842-199401000-00005","volume":"56","author":"MA Gupta","year":"1994","unstructured":"Gupta MA, Gupta AK, Schork NJ, Ellis CN (1994) Depression modulates pruritus perception: a study of pruritus in psoriasis, atopic dermatitis, and chronic idiopathic urticaria. Psychosom Med 56:36\u201340","journal-title":"Psychosom Med"},{"key":"1999_CR64","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1208\/s12248-012-9432-8","volume":"15","author":"SC Gupta","year":"2013","unstructured":"Gupta SC, Patchva S, Aggarwal BB (2013) Therapeutic roles of curcumin: lessons learned from clinical trials. AAPS J 15:195\u2013218","journal-title":"AAPS J"},{"key":"1999_CR65","doi-asserted-by":"publisher","first-page":"388","DOI":"10.1016\/j.ymeth.2007.03.005","volume":"42","author":"F Habeeb","year":"2007","unstructured":"Habeeb F et al (2007) The inner gel component of Aloe vera suppresses bacterial-induced pro-inflammatory cytokines from human immune cells. Methods 42:388\u2013393","journal-title":"Methods"},{"key":"1999_CR66","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1111\/j.1600-0536.2008.01402.x","volume":"59","author":"L Hagvall","year":"2008","unstructured":"Hagvall L, Sk\u00f6ld M, Br\u00e5red-Christensson J, B\u00f6rje A, Karlberg AT (2008) Lavender oil lacks natural protection against autoxidation, forming strong contact allergens on air exposure. Contact Dermatitis 59:143\u2013150","journal-title":"Contact Dermatitis"},{"key":"1999_CR67","doi-asserted-by":"publisher","first-page":"1669","DOI":"10.1111\/bph.15390","volume":"178","author":"Y Han","year":"2021","unstructured":"Han Y et al (2021) A plant-derived TRPV3 inhibitor suppresses pain and itch. Br J Pharmacol 178:1669\u20131683","journal-title":"Br J Pharmacol"},{"key":"1999_CR68","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2021.e07240","author":"MK Hasan","year":"2021","unstructured":"Hasan MK, Ara I, Mondal MSA, Kabir Y (2021) Phytochemistry, pharmacological activity, and potential health benefits of Glycyrrhiza glabra. Heliyon. https:\/\/doi.org\/10.1016\/j.heliyon.2021.e07240","journal-title":"Heliyon"},{"key":"1999_CR69","doi-asserted-by":"publisher","first-page":"1373","DOI":"10.1111\/exd.13705","volume":"28","author":"T Hashimoto","year":"2019","unstructured":"Hashimoto T, Rosen JD, Sanders KM, Yosipovitch G (2019) Possible roles of basophils in chronic itch. Exp Dermatol 28:1373\u20131379","journal-title":"Exp Dermatol"},{"key":"1999_CR70","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1111\/j.1749-6632.2009.05128.x","volume":"1183","author":"R He","year":"2010","unstructured":"He R, Geha RS (2010) Thymic stromal lymphopoietin. Ann N Y Acad Sci 1183:13\u201324","journal-title":"Ann N Y Acad Sci"},{"key":"1999_CR71","first-page":"22976","volume":"9","author":"Z-G He","year":"2016","unstructured":"He Z-G et al (2016) Neural circuits of pain and itch processing involved in anterior cingulate cortex. Int J Clin Exp Med 9:22976\u201322984","journal-title":"Int J Clin Exp Med"},{"key":"1999_CR72","first-page":"1","volume":"44","author":"D Hekmatpou","year":"2019","unstructured":"Hekmatpou D, Mehrabi F, Rahzani K, Aminiyan A (2019) The effect of aloe vera clinical trials on prevention and healing of skin wound: a systematic review. Iran J Med Sci 44:1","journal-title":"Iran J Med Sci"},{"key":"1999_CR73","doi-asserted-by":"publisher","first-page":"92","DOI":"10.3390\/foods6100092","volume":"6","author":"SJ Hewlings","year":"2017","unstructured":"Hewlings SJ, Kalman DS (2017) Curcumin: a review of its effects on human health. Foods 6:92","journal-title":"Foods"},{"key":"1999_CR74","doi-asserted-by":"publisher","first-page":"27","DOI":"10.3390\/biomedicines8020027","volume":"8","author":"J Hoffmann","year":"2020","unstructured":"Hoffmann J, Gendrisch F, Schempp CM, W\u00f6lfle U (2020) New herbal biomedicines for the topical treatment of dermatological disorders. Biomedicines 8:27","journal-title":"Biomedicines"},{"key":"1999_CR75","doi-asserted-by":"publisher","first-page":"7090","DOI":"10.1111\/jocd.15383","volume":"21","author":"DD Hou","year":"2022","unstructured":"Hou DD et al (2022) Glycyrrhizic acid suppresses atopic dermatitis-like symptoms by regulating the immune balance. J Cosmet Dermatol 21:7090\u20137099","journal-title":"J Cosmet Dermatol"},{"key":"1999_CR76","doi-asserted-by":"publisher","first-page":"e10633","DOI":"10.1097\/MD.0000000000010633","volume":"97","author":"X Hu","year":"2018","unstructured":"Hu X, Sang Y, Yang M, Chen X, Tang W (2018) Prevalence of chronic kidney disease-associated pruritus among adult dialysis patients: a meta-analysis of cross-sectional studies. Medicine (Baltimore) 97:e10633","journal-title":"Medicine (Baltimore)"},{"issue":"480\u2013483","key":"1999_CR77","first-page":"e484","volume":"140","author":"AH Huang","year":"2020","unstructured":"Huang AH, Canner JK, Khanna R, Kang S, Kwatra SG (2020) Real-world prevalence of prurigo nodularis and burden of associated diseases. J Investig Dermatol 140(480\u2013483):e484","journal-title":"J Investig Dermatol"},{"key":"1999_CR78","doi-asserted-by":"publisher","first-page":"535","DOI":"10.2340\/00015555-1344","volume":"92","author":"T Huesmann","year":"2012","unstructured":"Huesmann T et al (2012) Notalgia paraesthetica: a descriptive two-cohort study of 65 patients from Brazil and Germany. Acta Derm Venereol 92:535\u2013540","journal-title":"Acta Derm Venereol"},{"key":"1999_CR79","doi-asserted-by":"publisher","first-page":"535","DOI":"10.1038\/nrn1950","volume":"7","author":"A Ikoma","year":"2006","unstructured":"Ikoma A, Steinhoff M, St\u00e4nder S, Yosipovitch G, Schmelz M (2006) The neurobiology of itch. Nat Rev Neurosci 7:535\u2013547","journal-title":"Nat Rev Neurosci"},{"key":"1999_CR80","doi-asserted-by":"publisher","first-page":"737","DOI":"10.1093\/intimm\/dxab076","volume":"33","author":"H Irie","year":"2021","unstructured":"Irie H, Kabashima K (2021) The interaction between the immune system and the peripheral sensory nerves in pruritus. Int Immunol 33:737\u2013742","journal-title":"Int Immunol"},{"key":"1999_CR81","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1016\/j.yrtph.2006.06.002","volume":"46","author":"R Isbrucker","year":"2006","unstructured":"Isbrucker R, Burdock G (2006) Risk and safety assessment on the consumption of licorice root (Glycyrrhiza sp.), its extract and powder as a food ingredient, with emphasis on the pharmacology and toxicology of glycyrrhizin. Regul Toxicol Pharmacol 46:167\u2013192","journal-title":"Regul Toxicol Pharmacol"},{"key":"1999_CR82","doi-asserted-by":"publisher","first-page":"210","DOI":"10.3390\/cosmetics11060210","volume":"11","author":"S Javed","year":"2024","unstructured":"Javed S et al (2024) Essential oils as dermocosmetic agents, their mechanism of action and nanolipidic formulations for maximized skincare. Cosmet 11:210","journal-title":"Cosmet"},{"key":"1999_CR83","doi-asserted-by":"publisher","first-page":"6941","DOI":"10.3390\/molecules19066941","volume":"19","author":"IH Jeon","year":"2014","unstructured":"Jeon IH et al (2014) Anti-inflammatory and antipruritic effects of luteolin from Perilla (P. frutescens L.) leaves. Molecules 19:6941\u20136951","journal-title":"Molecules"},{"key":"1999_CR84","doi-asserted-by":"publisher","first-page":"3474","DOI":"10.4049\/jimmunol.163.6.3474","volume":"163","author":"C Jobin","year":"1999","unstructured":"Jobin C et al (1999) Curcumin blocks cytokine-mediated NF-\u03baB activation and proinflammatory gene expression by inhibiting inhibitory factor I-\u03baB kinase activity. J Immunol 163:3474\u20133483","journal-title":"J Immunol"},{"key":"1999_CR85","doi-asserted-by":"publisher","first-page":"659","DOI":"10.5114\/ada.2019.84007","volume":"36","author":"K Kaaz","year":"2019","unstructured":"Kaaz K, Szepietowski J, Matusiak \u0141 (2019) Sleep quality among adult patients with chronic dermatoses. Adv Dermatol Allergol\/post\u0119py Dermatologii i Alergologii 36:659\u2013666","journal-title":"Adv Dermatol Allergol\/post\u0119py Dermatologii i Alergologii"},{"key":"1999_CR86","doi-asserted-by":"publisher","first-page":"3049","DOI":"10.3390\/plants12173049","volume":"12","author":"I Kandilarov","year":"2023","unstructured":"Kandilarov I et al (2023) Effect of plant extracts combinations on TNF-\u03b1, IL-6 and IL-10 levels in serum of rats exposed to acute and chronic stress. Plants 12:3049","journal-title":"Plants"},{"key":"1999_CR87","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1208\/s12249-024-02785-y","volume":"25","author":"B Kashyap","year":"2024","unstructured":"Kashyap B, Khan A, Kapoor DN (2024) Eugenol-loaded transethosomal gel for improved skin delivery and treatment of atopic dermatitis. AAPS PharmSciTech 25:72","journal-title":"AAPS PharmSciTech"},{"key":"1999_CR88","doi-asserted-by":"publisher","first-page":"659","DOI":"10.1016\/j.jaad.2013.12.015","volume":"70","author":"SB Kaushik","year":"2014","unstructured":"Kaushik SB et al (2014) Chronic pruritus in HIV-positive patients in the southeastern United States: its prevalence and effect on quality of life. J Am Acad Dermatol 70:659\u2013664","journal-title":"J Am Acad Dermatol"},{"key":"1999_CR89","doi-asserted-by":"publisher","first-page":"1553","DOI":"10.1080\/10408398.2023.2296991","volume":"65","author":"A Kazemi","year":"2025","unstructured":"Kazemi A, Iraji A, Esmaealzadeh N, Salehi M, Hashempur MH (2025) Peppermint and menthol: a review on their biochemistry, pharmacological activities, clinical applications, and safety considerations. Crit Rev Food Sci Nutr 65:1553\u20131578","journal-title":"Crit Rev Food Sci Nutr"},{"key":"1999_CR90","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1016\/j.neulet.2004.01.019","volume":"361","author":"BM Kim","year":"2004","unstructured":"Kim BM, Lee SH, Shim WS, Oh U (2004) Histamine-induced Ca2+ influx via the PLA2\/lipoxygenase\/TRPV1 pathway in rat sensory neurons. Neurosci Lett 361:159\u2013162","journal-title":"Neurosci Lett"},{"key":"1999_CR91","doi-asserted-by":"publisher","first-page":"669","DOI":"10.1111\/bjd.16498","volume":"179","author":"H Kim","year":"2018","unstructured":"Kim H et al (2018) Itch in dermatomyositis: the role of increased skin interleukin-31. Br J Dermatol 179:669\u2013678","journal-title":"Br J Dermatol"},{"key":"1999_CR92","doi-asserted-by":"publisher","first-page":"96","DOI":"10.2340\/00015555-3855","volume":"101","author":"JC Kim","year":"2021","unstructured":"Kim JC et al (2021) Activation of transient receptor potential vanilloid-3 channels in keratinocytes induces pruritus in humans. Acta Derm Venereol 101:96","journal-title":"Acta Derm Venereol"},{"key":"1999_CR93","doi-asserted-by":"publisher","first-page":"1280","DOI":"10.3390\/ph15101280","volume":"15","author":"E-N Kim","year":"2022","unstructured":"Kim E-N, Lee H-S, Jeong G-S (2022) Callicarpa dichotoma leaf extract alleviates atopic dermatitis through the suppression of T cells and keratinocytes activation. Pharmaceuticals 15:1280","journal-title":"Pharmaceuticals"},{"key":"1999_CR94","doi-asserted-by":"publisher","first-page":"153679","DOI":"10.1016\/j.phymed.2021.153679","volume":"91","author":"R Kishimoto","year":"2021","unstructured":"Kishimoto R et al (2021) Topical treatment with mastic (resin from Pistacia lentiscus) elicits anti-inflammatory and anti-pruritic responses by modulating keratinocyte activation in a mouse model of allergic dermatitis. Phytomedicine 91:153679","journal-title":"Phytomedicine"},{"key":"1999_CR95","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1016\/j.alit.2016.10.003","volume":"66","author":"H Kittaka","year":"2017","unstructured":"Kittaka H, Tominaga M (2017) The molecular and cellular mechanisms of itch and the involvement of TRP channels in the peripheral sensory nervous system and skin. Allergol Int 66:22\u201330","journal-title":"Allergol Int"},{"key":"1999_CR96","doi-asserted-by":"publisher","first-page":"1522","DOI":"10.1001\/archderm.135.12.1522","volume":"135","author":"PA Klein","year":"1999","unstructured":"Klein PA, Clark RA (1999) An evidence-based review of the efficacy of antihistamines in relieving pruritus in atopic dermatitis. Arch Dermatol 135:1522\u20131525","journal-title":"Arch Dermatol"},{"key":"1999_CR97","doi-asserted-by":"publisher","first-page":"142","DOI":"10.1097\/AJP.0b013e318158ed9e","volume":"24","author":"H Knotkova","year":"2008","unstructured":"Knotkova H, Pappagallo M, Szallasi A (2008) Capsaicin (TRPV1 agonist) therapy for pain relief: farewell or revival? Clin J Pain 24:142\u2013154","journal-title":"Clin J Pain"},{"key":"1999_CR98","doi-asserted-by":"publisher","first-page":"308","DOI":"10.1016\/j.jep.2005.05.003","volume":"101","author":"Y Kobayashi","year":"2005","unstructured":"Kobayashi Y, Takahashi R, Ogino F (2005) Antipruritic effect of the single oral administration of German chamomile flower extract and its combined effect with antiallergic agents in ddY mice. J Ethnopharmacol 101:308\u2013312","journal-title":"J Ethnopharmacol"},{"key":"1999_CR99","doi-asserted-by":"publisher","first-page":"1212","DOI":"10.1046\/j.1365-2133.2002.05034.x","volume":"147","author":"K Koh","year":"2002","unstructured":"Koh K, Pearce A, Marshman G, Finlay-Jones J, Hart PH (2002) Tea tree oil reduces histamine-induced skin inflammation. Br J Dermatol 147:1212\u20131217","journal-title":"Br J Dermatol"},{"key":"1999_CR100","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1124\/jpet.114.215749","volume":"350","author":"A Kollmeier","year":"2014","unstructured":"Kollmeier A et al (2014) The histamine H4 receptor antagonist, JNJ 39758979, is effective in reducing histamine-induced pruritus in a randomized clinical study in healthy subjects. J Pharmacol Exp Ther 350:181\u2013187","journal-title":"J Pharmacol Exp Ther"},{"key":"1999_CR101","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1016\/j.ajp.2015.07.010","volume":"17","author":"D Konda","year":"2015","unstructured":"Konda D et al (2015) Serotonin and interleukin-6: association with pruritus severity, sleep quality and depression severity in Prurigo nodularis. Asian J Psychiatr 17:24\u201328","journal-title":"Asian J Psychiatr"},{"key":"1999_CR102","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1016\/S0885-3924(00)00256-6","volume":"21","author":"M Krajnik","year":"2001","unstructured":"Krajnik M, Zylicz Z (2001) Understanding pruritus in systemic disease. J Pain Symptom Manage 21:151\u2013168","journal-title":"J Pain Symptom Manage"},{"key":"1999_CR103","doi-asserted-by":"publisher","first-page":"1251","DOI":"10.1093\/ndt\/gfp588","volume":"25","author":"H Kumagai","year":"2010","unstructured":"Kumagai H et al (2010) Effect of a novel kappa-receptor agonist, nalfurafine hydrochloride, on severe itch in 337 haemodialysis patients: a phase III, randomized, double-blind, placebo-controlled study. Nephrol Dial Transplant 25:1251\u20131257","journal-title":"Nephrol Dial Transplant"},{"key":"1999_CR104","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1186\/s43094-023-00493-1","volume":"9","author":"B Kumar","year":"2023","unstructured":"Kumar B, Aggarwal R, Prakash U, Sahoo PK (2023) Emerging therapeutic potential of curcumin in the management of dermatological diseases: an extensive review of drug and pharmacological activities. Future J Pharm Sci 9:42","journal-title":"Future J Pharm Sci"},{"key":"1999_CR105","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-662-44605-8_12","author":"Y Kuraishi","year":"2015","unstructured":"Kuraishi Y (2015) Noradrenergic modulation of itch transmission in the spinal cord. Pharmacol Itch. https:\/\/doi.org\/10.1007\/978-3-662-44605-8_12","journal-title":"Pharmacol Itch"},{"key":"1999_CR106","doi-asserted-by":"publisher","first-page":"2703","DOI":"10.3390\/jcm9092703","volume":"9","author":"C Kwon","year":"2020","unstructured":"Kwon C et al (2020) Epidemiology and comorbidities of excoriation disorder: a retrospective case-control study. J Clin Med 9:2703","journal-title":"J Clin Med"},{"key":"1999_CR107","doi-asserted-by":"publisher","first-page":"931","DOI":"10.1016\/j.jaad.2018.08.044","volume":"80","author":"VA Larson","year":"2019","unstructured":"Larson VA, Tang O, St\u00e4nder S, Kang S, Kwatra SG (2019) Association between itch and cancer in 16,925 patients with pruritus: experience at a tertiary care center. J Am Acad Dermatol 80:931\u2013937","journal-title":"J Am Acad Dermatol"},{"key":"1999_CR108","doi-asserted-by":"publisher","first-page":"1691","DOI":"10.1080\/09546634.2021.1898529","volume":"33","author":"TK Le","year":"2022","unstructured":"Le TK et al (2022) Cutaneous adverse events of immune checkpoint inhibitor therapy: incidence and types of reactive dermatoses. J Dermatolog Treat 33:1691\u20131695","journal-title":"J Dermatolog Treat"},{"key":"1999_CR109","doi-asserted-by":"publisher","first-page":"2985","DOI":"10.3390\/ijms13032985","volume":"13","author":"K-H Lee","year":"2012","unstructured":"Lee K-H et al (2012) BDMC33, a curcumin derivative suppresses inflammatory responses in macrophage-like cellular system: role of inhibition in NF-\u03baB and MAPK signaling pathways. Int J Mol Sci 13:2985\u20133008","journal-title":"Int J Mol Sci"},{"key":"1999_CR110","doi-asserted-by":"publisher","first-page":"547","DOI":"10.4196\/kjpp.2018.22.5.547","volume":"22","author":"HK Lee","year":"2018","unstructured":"Lee HK, Park SB, Chang S-Y, Jung SJ (2018) Antipruritic effect of curcumin on histamine-induced itching in mice. Korean J Physiol Pharmacol 22:547","journal-title":"Korean J Physiol Pharmacol"},{"key":"1999_CR111","doi-asserted-by":"publisher","first-page":"415","DOI":"10.1016\/j.iac.2007.07.009","volume":"27","author":"KM Leiferman","year":"2007","unstructured":"Leiferman KM, Gleich GJ, Peters MS (2007) Dermatologic manifestations of the hypereosinophilic syndromes. Immunol Allergy Clin North Am 27:415\u2013441","journal-title":"Immunol Allergy Clin North Am"},{"key":"1999_CR112","doi-asserted-by":"publisher","first-page":"496","DOI":"10.2340\/00015555-2906","volume":"98","author":"E Lelonek","year":"2018","unstructured":"Lelonek E, Matusiak \u0141, Wrobel T, Szepietowski JC (2018) Aquagenic pruritus in polycythemia vera: clinical characteristics. Acta Derm Venereol 98:496\u2013500","journal-title":"Acta Derm Venereol"},{"key":"1999_CR113","doi-asserted-by":"publisher","first-page":"1006908","DOI":"10.3389\/fnmol.2022.1006908","volume":"15","author":"Z Li","year":"2022","unstructured":"Li Z et al (2022) The distinctive role of menthol in pain and analgesia: mechanisms, practices, and advances. Front Mol Neurosci 15:1006908","journal-title":"Front Mol Neurosci"},{"key":"1999_CR114","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics17020144","author":"A Liakopoulou","year":"2025","unstructured":"Liakopoulou A et al (2025) Curcumin-loaded lipid nanocarriers: a targeted approach for combating oxidative stress in skin applications. Pharmaceutics. https:\/\/doi.org\/10.3390\/pharmaceutics17020144","journal-title":"Pharmaceutics"},{"key":"1999_CR115","doi-asserted-by":"publisher","first-page":"70","DOI":"10.3390\/ijms19010070","volume":"19","author":"T-K Lin","year":"2018","unstructured":"Lin T-K, Zhong L, Santiago JL (2018) Anti-inflammatory and skin barrier repair effects of topical application of some plant oils. Int J Mol Sci 19:70","journal-title":"Int J Mol Sci"},{"key":"1999_CR116","doi-asserted-by":"publisher","first-page":"148","DOI":"10.1016\/j.jaad.2020.08.117","volume":"84","author":"ZM Lipman","year":"2021","unstructured":"Lipman ZM, Yosipovitch G (2021) Substance use disorders and chronic itch. J Am Acad Dermatol 84:148\u2013155","journal-title":"J Am Acad Dermatol"},{"key":"1999_CR117","doi-asserted-by":"publisher","first-page":"467","DOI":"10.3390\/ijms25010467","volume":"25","author":"S L\u00f3pez-Enr\u00edquez","year":"2023","unstructured":"L\u00f3pez-Enr\u00edquez S, M\u00fanera-Rodr\u00edguez AM, Leiva-Castro C, Sobrino F, Palomares F (2023) Modulation of the immune response to allergies using alternative functional foods. Int J Mol Sci 25:467","journal-title":"Int J Mol Sci"},{"key":"1999_CR118","doi-asserted-by":"publisher","first-page":"5411","DOI":"10.4049\/jimmunol.154.10.5411","volume":"154","author":"NW Lukacs","year":"1995","unstructured":"Lukacs NW, Strieter RM, Chensue SW, Widmer M, Kunkel SL (1995) TNF-alpha mediates recruitment of neutrophils and eosinophils during airway inflammation. J Immunol 154:5411\u20135417","journal-title":"J Immunol"},{"key":"1999_CR119","doi-asserted-by":"publisher","first-page":"1258823","DOI":"10.3389\/fnmol.2023.1258823","volume":"16","author":"MR Mack","year":"2023","unstructured":"Mack MR et al (2023) Type 2 cytokines sensitize human sensory neurons to itch-associated stimuli. Front Mol Neurosci 16:1258823","journal-title":"Front Mol Neurosci"},{"key":"1999_CR120","doi-asserted-by":"publisher","first-page":"1272230","DOI":"10.3389\/fnmol.2023.1272230","volume":"16","author":"O Mahmoud","year":"2023","unstructured":"Mahmoud O, Oladipo O, Mahmoud RH, Yosipovitch G (2023) Itch: from the skin to the brain\u2013peripheral and central neural sensitization in chronic itch. Front Mol Neurosci 16:1272230","journal-title":"Front Mol Neurosci"},{"key":"1999_CR121","doi-asserted-by":"publisher","first-page":"853","DOI":"10.1159\/000325860","volume":"51","author":"S Mandal","year":"2007","unstructured":"Mandal S, Varma K, Jain S (2007) Cutaneous manifestations in non-Hodgkin\u2019s lymphoma. Acta Cytol 51:853\u2013859","journal-title":"Acta Cytol"},{"key":"1999_CR122","doi-asserted-by":"publisher","first-page":"5001","DOI":"10.3390\/ijms24055001","volume":"24","author":"L Marek-Jozefowicz","year":"2023","unstructured":"Marek-Jozefowicz L et al (2023) Molecular mechanisms of neurogenic inflammation of the skin. Int J Mol Sci 24:5001","journal-title":"Int J Mol Sci"},{"key":"1999_CR123","doi-asserted-by":"publisher","first-page":"1724","DOI":"10.3390\/pharmaceutics15061724","volume":"15","author":"MP Marques","year":"2023","unstructured":"Marques MP, Varela C, Mendon\u00e7a L, Cabral C (2023) Nanotechnology-based topical delivery of natural products for the management of atopic dermatitis. Pharmaceutics 15:1724","journal-title":"Pharmaceutics"},{"key":"1999_CR124","doi-asserted-by":"publisher","first-page":"756","DOI":"10.1016\/j.jaad.2010.07.036","volume":"65","author":"M Marziniak","year":"2011","unstructured":"Marziniak M et al (2011) Brachioradial pruritus as a result of cervical spine pathology: the results of a magnetic resonance tomography study. J Am Acad Dermatol 65:756\u2013762","journal-title":"J Am Acad Dermatol"},{"key":"1999_CR125","doi-asserted-by":"publisher","first-page":"697","DOI":"10.1056\/NEJM196809262791308","volume":"279","author":"SG Massry","year":"1968","unstructured":"Massry SG et al (1968) Intractable pruritus as a manifestation of secondary hyperparathyroidism in uremia. Disappearance of itching after subtotal parathyroidectomy. N Engl J Med 279:697\u2013700","journal-title":"N Engl J Med"},{"issue":"1163\u20131171","key":"1999_CR126","first-page":"e1165","volume":"50","author":"J Meixiong","year":"2019","unstructured":"Meixiong J et al (2019a) Activation of mast-cell-expressed mas-related G-protein-coupled receptors drives non-histaminergic itch. Immunity 50(1163\u20131171):e1165","journal-title":"Immunity"},{"key":"1999_CR127","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.44116","volume":"8","author":"J Meixiong","year":"2019","unstructured":"Meixiong J et al (2019b) Identification of a bilirubin receptor that may mediate a component of cholestatic itch. Elife 8:e44116","journal-title":"Elife"},{"key":"1999_CR128","doi-asserted-by":"publisher","first-page":"15551","DOI":"10.1038\/s41598-018-33620-7","volume":"8","author":"H Melo","year":"2018","unstructured":"Melo H et al (2018) Itch induced by peripheral mu opioid receptors is dependent on TRPV1-expressing neurons and alleviated by channel activation. Sci Rep 8:15551","journal-title":"Sci Rep"},{"key":"1999_CR129","doi-asserted-by":"publisher","first-page":"1033","DOI":"10.1152\/physrev.1997.77.4.1033","volume":"77","author":"DD Metcalfe","year":"1997","unstructured":"Metcalfe DD, Baram D, Mekori YA (1997) Mast cells. Physiol Rev 77:1033\u20131079","journal-title":"Physiol Rev"},{"key":"1999_CR130","doi-asserted-by":"publisher","first-page":"1249","DOI":"10.1111\/j.1468-3083.2010.03850.x","volume":"24","author":"M Metz","year":"2010","unstructured":"Metz M, St\u00e4nder S (2010) Chronic pruritus\u2013pathogenesis, clinical aspects and treatment. J Eur Acad Dermatol Venereol 24:1249\u20131260","journal-title":"J Eur Acad Dermatol Venereol"},{"key":"1999_CR131","doi-asserted-by":"publisher","first-page":"690","DOI":"10.1016\/j.jaci.2022.01.028","volume":"150","author":"Y Miron","year":"2022","unstructured":"Miron Y et al (2022) Mechanistic insights into the antipruritic effects of lebrikizumab, an anti\u2013IL-13 mAb. J Allergy Clin Immunol 150:690\u2013700","journal-title":"J Allergy Clin Immunol"},{"key":"1999_CR132","doi-asserted-by":"publisher","first-page":"1007","DOI":"10.1111\/bjd.12483","volume":"169","author":"S Mirzoyev","year":"2013","unstructured":"Mirzoyev S, Davis M (2013) Brachioradial pruritus: Mayo Clinic experience over the past decade. Br J Dermatol 169:1007\u20131015","journal-title":"Br J Dermatol"},{"key":"1999_CR133","doi-asserted-by":"publisher","first-page":"1650","DOI":"10.1016\/j.clinph.2014.11.019","volume":"126","author":"H Mochizuki","year":"2015","unstructured":"Mochizuki H, Kakigi R (2015) Central mechanisms of itch. Clin Neurophysiol 126:1650\u20131660","journal-title":"Clin Neurophysiol"},{"key":"1999_CR134","doi-asserted-by":"publisher","DOI":"10.35588\/blacpma.19.18.1.01","author":"F Mohajerani","year":"2019","unstructured":"Mohajerani F, Hajimahmoodi M, Shirbeigi L, Rahimi R (2019) Medicinal plants as a source of future anti-pruritic drugs: a comprehensive review. Bol Latinoam Caribe Plantas Med Aromat. https:\/\/doi.org\/10.35588\/blacpma.19.18.1.01","journal-title":"Bol Latinoam Caribe Plantas Med Aromat"},{"key":"1999_CR135","doi-asserted-by":"publisher","first-page":"1064","DOI":"10.1001\/archderm.1980.01640330102026","volume":"116","author":"DM Morrow","year":"1980","unstructured":"Morrow DM, Rapaport MJ, Strick RA (1980) Hypersensitivity to aloe. Arch Dermatol 116:1064\u20131065","journal-title":"Arch Dermatol"},{"key":"1999_CR136","doi-asserted-by":"publisher","first-page":"1058","DOI":"10.1111\/jdv.17029","volume":"35","author":"P Najafi","year":"2021","unstructured":"Najafi P, Dufor O, Ben Salem D, Misery L, Carr\u00e9 JL (2021) Itch processing in the brain. J Eur Acad Dermatol Venereol 35:1058\u20131066","journal-title":"J Eur Acad Dermatol Venereol"},{"key":"1999_CR137","doi-asserted-by":"publisher","first-page":"273","DOI":"10.2337\/diacare.9.3.273","volume":"9","author":"J Neilly","year":"1986","unstructured":"Neilly J, Martin A, Simpson N, MacCuish A (1986) Pruritus in diabetes mellitus: investigation of prevalence and correlation with diabetes control. Diabetes Care 9:273\u2013275","journal-title":"Diabetes Care"},{"issue":"217\u2013228","key":"1999_CR138","first-page":"e213","volume":"171","author":"LK Oetjen","year":"2017","unstructured":"Oetjen LK et al (2017) Sensory neurons co-opt classical immune signaling pathways to mediate chronic itch. Cell 171(217\u2013228):e213","journal-title":"Cell"},{"key":"1999_CR139","doi-asserted-by":"publisher","first-page":"719","DOI":"10.1016\/j.pbb.2004.05.013","volume":"78","author":"FA Oliveira","year":"2004","unstructured":"Oliveira FA et al (2004) Pentacyclic triterpenoids, \u03b1, \u03b2-amyrins, suppress the scratching behavior in a mouse model of pruritus. Pharmacol Biochem Behav 78:719\u2013725","journal-title":"Pharmacol Biochem Behav"},{"key":"1999_CR140","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1177\/2042018812454322","volume":"3","author":"HR Omar","year":"2012","unstructured":"Omar HR et al (2012) Licorice abuse: time to send a warning message. Ther Adv Endocrinol Metab 3:125\u2013138","journal-title":"Ther Adv Endocrinol Metab"},{"key":"1999_CR141","doi-asserted-by":"publisher","first-page":"384","DOI":"10.1007\/s11882-996-0008-5","volume":"6","author":"PY Ong","year":"2006","unstructured":"Ong PY, Leung DM (2006) Immune dysregulation in atopic dermatitis. Curr Allergy Asthma Rep 6:384\u2013389","journal-title":"Curr Allergy Asthma Rep"},{"key":"1999_CR142","doi-asserted-by":"publisher","first-page":"248","DOI":"10.1016\/j.biopha.2016.01.029","volume":"78","author":"MI Ortiz","year":"2016","unstructured":"Ortiz MI et al (2016) Isolation, identification and molecular docking as cyclooxygenase (COX) inhibitors of the main constituents of Matricaria chamomilla L. extract and its synergistic interaction with diclofenac on nociception and gastric damage in rats. Biomed Pharmacother 78:248\u2013256","journal-title":"Biomed Pharmacother"},{"key":"1999_CR143","doi-asserted-by":"publisher","first-page":"1391","DOI":"10.1016\/j.jid.2017.12.025","volume":"138","author":"R Palkar","year":"2018","unstructured":"Palkar R et al (2018) Cooling relief of acute and chronic itch requires TRPM8 channels and neurons. J Invest Dermatol 138:1391\u20131399","journal-title":"J Invest Dermatol"},{"issue":"1135\u20131149","key":"1999_CR144","first-page":"e1136","volume":"103","author":"H Pan","year":"2019","unstructured":"Pan H et al (2019) Identification of a spinal circuit for mechanical and persistent spontaneous itch. Neuron 103(1135\u20131149):e1136","journal-title":"Neuron"},{"key":"1999_CR145","doi-asserted-by":"publisher","first-page":"375671","DOI":"10.1155\/2012\/375671","volume":"2012","author":"LML Parente","year":"2012","unstructured":"Parente LML et al (2012) Wound healing and anti-inflammatory effect in animal models of Calendula officinalis L. growing in Brazil. Evid Based Complement Altern Med 2012:375671","journal-title":"Evid Based Complement Altern Med"},{"key":"1999_CR146","doi-asserted-by":"publisher","first-page":"5360","DOI":"10.1111\/jocd.15094","volume":"21","author":"MM Parvizi","year":"2022","unstructured":"Parvizi MM et al (2022) Complementary and integrative remedies in the treatment of chronic pruritus: a review of clinical trials. J Cosmet Dermatol 21:5360\u20135369","journal-title":"J Cosmet Dermatol"},{"key":"1999_CR147","doi-asserted-by":"publisher","first-page":"2323","DOI":"10.1002\/ptr.6178","volume":"32","author":"G Pastorino","year":"2018","unstructured":"Pastorino G, Cornara L, Soares S, Rodrigues F, Oliveira MBP (2018a) Liquorice (Glycyrrhiza glabra): a phytochemical and pharmacological review. Phytother Res 32:2323\u20132339","journal-title":"Phytother Res"},{"key":"1999_CR148","doi-asserted-by":"publisher","first-page":"1371","DOI":"10.1016\/j.jaad.2019.04.035","volume":"81","author":"SP Patel","year":"2019","unstructured":"Patel SP et al (2019) Cholestatic pruritus: emerging mechanisms and therapeutics. J Am Acad Dermatol 81:1371\u20131378","journal-title":"J Am Acad Dermatol"},{"key":"1999_CR149","doi-asserted-by":"publisher","first-page":"238","DOI":"10.1016\/j.jid.2019.06.130","volume":"140","author":"SP Patel","year":"2020","unstructured":"Patel SP, Khanna R, Belzberg M, Kang S, Kwatra SG (2020) Elevated blood cadmium and lead levels in chronic pruritic dermatoses. J Invest Dermatol 140:238\u2013241","journal-title":"J Invest Dermatol"},{"key":"1999_CR150","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1016\/j.jaad.2020.08.059","volume":"84","author":"SP Patel","year":"2021","unstructured":"Patel SP et al (2021) Sleep disturbance in adults with chronic pruritic dermatoses is associated with increased C-reactive protein levels. J Am Acad Dermatol 84:265\u2013272","journal-title":"J Am Acad Dermatol"},{"key":"1999_CR151","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1034\/j.1600-0536.2002.470401.x","volume":"47","author":"E Paulsen","year":"2002","unstructured":"Paulsen E (2002) Contact sensitization from compositae-containing herbal remedies and cosmetics. Contact Dermatitis 47:189\u2013198","journal-title":"Contact Dermatitis"},{"key":"1999_CR152","doi-asserted-by":"publisher","first-page":"1174","DOI":"10.1172\/JCI28553","volume":"116","author":"R Paus","year":"2006","unstructured":"Paus R, Schmelz M, B\u00edr\u00f3 T, Steinhoff M (2006) Frontiers in pruritus research: scratching the brain for more effective itch therapy. J Clin Invest 116:1174\u20131186","journal-title":"J Clin Invest"},{"key":"1999_CR153","doi-asserted-by":"publisher","first-page":"102573","DOI":"10.1016\/j.conb.2022.102573","volume":"75","author":"MP Pereira","year":"2022","unstructured":"Pereira MP, Schmelz M, St\u00e4nder S (2022) Mechanisms and therapeutic targets for neuropathic itch. Curr Opin Neurobiol 75:102573","journal-title":"Curr Opin Neurobiol"},{"key":"1999_CR154","doi-asserted-by":"publisher","first-page":"549","DOI":"10.1590\/abd1806-4841.201644767","volume":"91","author":"ACVD Pinto","year":"2016","unstructured":"Pinto ACVD, Wachholz PA, Masuda PY, Martelli ACC (2016) Clinical, epidemiological and therapeutic profile of patients with brachioradial pruritus in a reference service in dermatology. An Bras Dermatol 91:549\u2013551","journal-title":"An Bras Dermatol"},{"key":"1999_CR155","doi-asserted-by":"publisher","first-page":"2","DOI":"10.4143\/crt.2014.46.1.2","volume":"46","author":"S Prasad","year":"2014","unstructured":"Prasad S, Tyagi AK, Aggarwal BB (2014) Recent developments in delivery, bioavailability, absorption and metabolism of curcumin: the golden pigment from golden spice. Cancer Res Treat 46:2\u201318","journal-title":"Cancer Res Treat"},{"key":"1999_CR156","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1111\/j.1365-4632.2005.02079.x","volume":"44","author":"E Proksch","year":"2005","unstructured":"Proksch E, Nissen HP, Bremgartner M, Urquhart C (2005) Bathing in a magnesium-rich Dead Sea salt solution improves skin barrier function, enhances skin hydration, and reduces inflammation in atopic dry skin. Int J Dermatol 44:151\u2013157","journal-title":"Int J Dermatol"},{"key":"1999_CR157","first-page":"105","volume":"8","author":"M Rashidipour","year":"2023","unstructured":"Rashidipour M et al (2023) Effects of the topical application of Lavandula officinalis L. essential oil on reducing the severity of eczema symptoms: a randomized clinical trial. Herb Med J 8:105\u2013112","journal-title":"Herb Med J"},{"key":"1999_CR158","doi-asserted-by":"publisher","first-page":"2056","DOI":"10.1093\/rheumatology\/ket275","volume":"52","author":"I Razykov","year":"2013","unstructured":"Razykov I, Levis B, Hudson M, Baron M, Thombs BD (2013) Prevalence and clinical correlates of pruritus in patients with systemic sclerosis: an updated analysis of 959 patients. Rheumatology 52:2056\u20132061","journal-title":"Rheumatology"},{"key":"1999_CR159","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1034\/j.1600-0536.2001.450503.x","volume":"45","author":"N Reider","year":"2001","unstructured":"Reider N, Komericki P, Hausen B, Fritsch P, Aberer W (2001) The seamy side of natural medicines: contact sensitization to arnica (Arnica montana L.) and marigold (Calendula officinalis L.). Contact Dermatitis 45:269\u2013272","journal-title":"Contact Dermatitis"},{"key":"1999_CR160","doi-asserted-by":"publisher","first-page":"1422","DOI":"10.1111\/exd.13959","volume":"28","author":"R Reszke","year":"2019","unstructured":"Reszke R, Szepietowski JC (2019) Can we use psychoactive drugs to treat pruritus? Exp Dermatol 28:1422\u20131431","journal-title":"Exp Dermatol"},{"key":"1999_CR161","doi-asserted-by":"publisher","first-page":"106","DOI":"10.1159\/000114871","volume":"21","author":"J Reuter","year":"2008","unstructured":"Reuter J et al (2008) Investigation of the anti-inflammatory potential of Aloe vera gel (97.5%) in the ultraviolet erythema test. Skin Pharmacol Physiol 21:106\u2013110","journal-title":"Skin Pharmacol Physiol"},{"key":"1999_CR162","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1111\/bjd.13167","volume":"172","author":"E Robinson","year":"2015","unstructured":"Robinson E, Feng R, Okawa J, Werth V (2015) Improvement in the cutaneous disease activity of patients with dermatomyositis is associated with a better quality of life. Br J Dermatol 172:169\u2013174","journal-title":"Br J Dermatol"},{"key":"1999_CR163","doi-asserted-by":"publisher","first-page":"479","DOI":"10.1016\/S0738-081X(99)00143-1","volume":"18","author":"GE Rodwell","year":"2000","unstructured":"Rodwell GE, Berger T (2000) Pruritus and cutaneous inflammatory conditions in HIV disease. Clin Dermatol 18:479\u2013484","journal-title":"Clin Dermatol"},{"key":"1999_CR164","doi-asserted-by":"publisher","first-page":"920","DOI":"10.1002\/ptr.2763","volume":"23","author":"B Roschek Jr","year":"2009","unstructured":"Roschek B Jr, Fink RC, McMichael M, Alberte RS (2009) Nettle extract (Urtica dioica) affects key receptors and enzymes associated with allergic rhinitis. Phytother Res 23:920\u2013926","journal-title":"Phytother Res"},{"key":"1999_CR165","first-page":"55","volume":"105","author":"J Rupert","year":"2022","unstructured":"Rupert J, Honeycutt JD (2022) Pruritus diagnosis and management. Am Fam Phys 105:55\u201364","journal-title":"Am Fam Phys"},{"key":"1999_CR166","first-page":"90","volume":"21","author":"R Saini","year":"2022","unstructured":"Saini R, Dhiman NK (2022) Natural anti-inflammatory and anti-allergy agents: herbs and botanical ingredients. Anti-Inflamm Anti Allergy Agents Med Chem 21:90\u2013114","journal-title":"Anti-Inflamm Anti Allergy Agents Med Chem"},{"key":"1999_CR167","doi-asserted-by":"publisher","first-page":"636","DOI":"10.3390\/nano12040636","volume":"12","author":"K Saini","year":"2022","unstructured":"Saini K, Modgill N, Singh KK, Kakkar V (2022) Tetrahydrocurcumin lipid nanoparticle based gel promotes penetration into deeper skin layers and alleviates atopic dermatitis in 2, 4-dinitrochlorobenzene (DNCB) mouse model. Nanomaterials 12:636","journal-title":"Nanomaterials"},{"key":"1999_CR168","doi-asserted-by":"publisher","first-page":"84","DOI":"10.53801\/jcn.v1i3.47","volume":"1","author":"DWJW Sari","year":"2022","unstructured":"Sari DWJW (2022) OAT lotion reduces itching sensation due to pruritus in hemodialysis patients. J Complement Nurs 1:84\u201390","journal-title":"J Complement Nurs"},{"key":"1999_CR169","doi-asserted-by":"publisher","first-page":"1085","DOI":"10.1016\/j.jaad.2005.01.138","volume":"52","author":"O Savk","year":"2005","unstructured":"Savk O, Savk E (2005) Investigation of spinal pathology in notalgia paresthetica. J Am Acad Dermatol 52:1085\u20131087","journal-title":"J Am Acad Dermatol"},{"key":"1999_CR170","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1152\/physiologyonline.2001.16.1.33","volume":"16","author":"M Schmelz","year":"2001","unstructured":"Schmelz M, Petersen LJ (2001) Neurogenic inflammation in human and rodent skin. Physiology 16:33\u201337","journal-title":"Physiology"},{"key":"1999_CR171","doi-asserted-by":"publisher","first-page":"285","DOI":"10.1007\/978-3-662-46450-2_14","volume":"227","author":"M Schmelz","year":"2015","unstructured":"Schmelz M (2015) Itch and pain differences and commonalities. Pain Control 227:285\u2013301","journal-title":"Pain Control"},{"key":"1999_CR172","doi-asserted-by":"publisher","first-page":"762","DOI":"10.1111\/j.1365-2230.2006.02211.x","volume":"31","author":"G Schneider","year":"2006","unstructured":"Schneider G et al (2006) Psychosomatic cofactors and psychiatric comorbidity in patients with chronic itch. Clin Exp Dermatol 31:762\u2013767","journal-title":"Clin Exp Dermatol"},{"key":"1999_CR173","doi-asserted-by":"publisher","first-page":"1559","DOI":"10.1001\/jama.1977.03270420027007","volume":"237","author":"M Scribner","year":"1977","unstructured":"Scribner M (1977) Diabetes and pruritus of the scalp. JAMA 237:1559\u20131559","journal-title":"JAMA"},{"key":"1999_CR174","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1111\/j.1600-0625.2011.01433.x","volume":"21","author":"R Sekine","year":"2012","unstructured":"Sekine R, Satoh T, Takaoka A, Saeki K, Yokozeki H (2012) Anti pruritic effects of topical crotamiton, capsaicin, and a corticosteroid on pruritogen-induced scratching behavior. Exp Dermatol 21:201\u2013204","journal-title":"Exp Dermatol"},{"key":"1999_CR175","doi-asserted-by":"publisher","first-page":"4231854","DOI":"10.1155\/2022\/4231854","volume":"2022","author":"NZ Sepehri","year":"2022","unstructured":"Sepehri NZ, Parvizi MM, Habibzadeh S, Handjani F (2022) Lettuce as an effective remedy in uremic pruritus: review of the literature supplemented by an in silico study. Evid Based Complement Altern Med 2022:4231854","journal-title":"Evid Based Complement Altern Med"},{"key":"1999_CR176","doi-asserted-by":"publisher","first-page":"1301817","DOI":"10.3389\/fimmu.2023.1301817","volume":"14","author":"Y Shao","year":"2023","unstructured":"Shao Y et al (2023) Molecular mechanisms of pruritus in prurigo nodularis. Front Immunol 14:1301817","journal-title":"Front Immunol"},{"key":"1999_CR177","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1186\/s12906-024-04378-5","volume":"24","author":"M Sharifi","year":"2024","unstructured":"Sharifi M, Nourani N, Sanaie S, Hamedeyazdan S (2024) The effect of Oenothera biennis (Evening primrose) oil on inflammatory diseases: a systematic review of clinical trials. BMC Complement Med Ther 24:89","journal-title":"BMC Complement Med Ther"},{"issue":"S1","key":"1999_CR178","first-page":"1","volume":"34","author":"S Sharma","year":"2020","unstructured":"Sharma S, Naura AS (2020) Efficacy of the curcumin to ameliorate ovalbumin induced atopic dermatitis and progression of atopic march in mice. FASEB J 34(S1):1\u20131","journal-title":"FASEB J"},{"key":"1999_CR179","doi-asserted-by":"publisher","first-page":"140","DOI":"10.1016\/j.clindermatol.2017.10.005","volume":"36","author":"A Shevchenko","year":"2018","unstructured":"Shevchenko A et al (2018) Causes, pathophysiology, and treatment of pruritus in the mature patient. Clin Dermatol 36:140\u2013151","journal-title":"Clin Dermatol"},{"key":"1999_CR180","doi-asserted-by":"publisher","first-page":"1744","DOI":"10.1186\/1744-8069-4-29","volume":"4","author":"W-S Shim","year":"2008","unstructured":"Shim W-S, Oh U (2008) Histamine-induced itch and its relationship with pain. Mol Pain 4:1744\u20138069","journal-title":"Mol Pain"},{"key":"1999_CR181","doi-asserted-by":"publisher","first-page":"3003","DOI":"10.1016\/j.ajpath.2015.07.015","volume":"185","author":"K Shimizu","year":"2015","unstructured":"Shimizu K, Andoh T, Yoshihisa Y, Shimizu T (2015) Histamine released from epidermal keratinocytes plays a role in \u03b1-melanocyte\u2013stimulating hormone-induced itching in mice. Am J Pathol 185:3003\u20133010","journal-title":"Am J Pathol"},{"key":"1999_CR182","doi-asserted-by":"publisher","first-page":"039463202211354","DOI":"10.1177\/03946320221135462","volume":"36","author":"J Shu","year":"2022","unstructured":"Shu J et al (2022) Licochalcone A inhibits IgE-mediated allergic reaction through PLC\/ERK\/STAT3 pathway. Int J Immunopathol Pharmacol 36:03946320221135462","journal-title":"Int J Immunopathol Pharmacol"},{"key":"1999_CR183","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1055\/a-2321-9571","volume":"74","author":"S Singh","year":"2024","unstructured":"Singh S, Mishra A (2024) Linalool: therapeutic indication and their multifaceted biomedical applications. Drug Res 74:255\u2013268","journal-title":"Drug Res"},{"key":"1999_CR184","doi-asserted-by":"crossref","unstructured":"Snyder, L. M., and S. E. Ross. 2015. Itch and its inhibition by counter stimuli. Pharmacology of Itch: 191\u2013206.","DOI":"10.1007\/978-3-662-44605-8_11"},{"key":"1999_CR185","doi-asserted-by":"crossref","unstructured":"Sobhan, M. et al. 2020. The efficacy of colloidal oatmeal cream 1% as add-on therapy in the management of chronic irritant hand eczema: A double-blind study. Clinical, Cosmetic and Investigational Dermatology: 241\u2013251.","DOI":"10.2147\/CCID.S246021"},{"key":"1999_CR186","doi-asserted-by":"publisher","first-page":"411","DOI":"10.1016\/j.jaci.2005.10.033","volume":"117","author":"E Sonkoly","year":"2006","unstructured":"Sonkoly E et al (2006) IL-31: a new link between T cells and pruritus in atopic skin inflammation. J Allergy Clin Immunol 117:411\u2013417","journal-title":"J Allergy Clin Immunol"},{"key":"1999_CR187","first-page":"895","volume":"3","author":"JK Srivastava","year":"2010","unstructured":"Srivastava JK, Shankar E, Gupta S (2010) Chamomile: a herbal medicine of the past with a bright future. Mol Med Rep 3:895\u2013901","journal-title":"Mol Med Rep"},{"key":"1999_CR188","doi-asserted-by":"publisher","first-page":"291","DOI":"10.2340\/00015555-0305","volume":"87","author":"S Stander","year":"2007","unstructured":"Stander S et al (2007) Clinical classification of itch: a position paper of the International Forum for the Study of Itch. Acta Dermato-Venereol 87:291","journal-title":"Acta Dermato-Venereol"},{"key":"1999_CR189","doi-asserted-by":"publisher","first-page":"525","DOI":"10.1007\/s00482-020-00502-9","volume":"34","author":"S St\u00e4nder","year":"2020","unstructured":"St\u00e4nder S, Schmelz M (2020) Neuropathic pruritus. Schmerz 34:525\u2013535","journal-title":"Schmerz"},{"key":"1999_CR190","first-page":"415","volume":"18","author":"M Stawiski","year":"1976","unstructured":"Stawiski M, Voorhees J (1976) Cutaneous signs of diabetes mellitus. Cutis 18:415\u2013421","journal-title":"Cutis"},{"key":"1999_CR191","doi-asserted-by":"publisher","first-page":"709","DOI":"10.1016\/S1474-4422(18)30217-5","volume":"17","author":"M Steinhoff","year":"2018","unstructured":"Steinhoff M, Schmelz M, Szab\u00f3 IL, Oaklander AL (2018) Clinical presentation, management, and pathophysiology of neuropathic itch. Lancet Neurol 17:709\u2013720","journal-title":"Lancet Neurol"},{"key":"1999_CR192","doi-asserted-by":"publisher","first-page":"e2082","DOI":"10.1371\/journal.pone.0002082","volume":"3","author":"SC Stotz","year":"2008","unstructured":"Stotz SC, Vriens J, Martyn D, Clardy J, Clapham DE (2008) Citral sensing by transient receptor potential channels in dorsal root ganglion neurons. PLoS ONE 3:e2082","journal-title":"PLoS ONE"},{"key":"1999_CR193","doi-asserted-by":"publisher","first-page":"764","DOI":"10.3390\/ijms21030764","volume":"21","author":"L Subedi","year":"2020","unstructured":"Subedi L et al (2020) Phytochemicals against TNF \u03b1-mediated neuroinflammatory diseases. Int J Mol Sci 21:764","journal-title":"Int J Mol Sci"},{"key":"1999_CR194","first-page":"4314","volume":"8","author":"BJ Sudan","year":"2024","unstructured":"Sudan BJ (2024a) Magnesium of Dead Sea salts as a key factor for the treatment of seborrheic and atopic dermatitis: a case report. Bioscientia Medicina J Biomed Transl Res 8:4314\u20134318","journal-title":"Bioscientia Medicina J Biomed Transl Res"},{"key":"1999_CR195","doi-asserted-by":"crossref","unstructured":"Sudan, B. J. 2024b. Mast Cells, Magnesium Chloride and Seborrheic Dermatitis as an Allergic Skin Disease. International Journal of Innovative Research in Medical Science (IJIRMS) 9.","DOI":"10.23958\/ijirms\/vol09-i09\/1960"},{"key":"1999_CR196","doi-asserted-by":"publisher","first-page":"569","DOI":"10.1007\/s00403-008-0858-x","volume":"300","author":"R Sur","year":"2008","unstructured":"Sur R, Nigam A, Grote D, Liebel F, Southall MD (2008) Avenanthramides, polyphenols from oats, exhibit anti-inflammatory and anti-itch activity. Arch Dermatol Res 300:569\u2013574","journal-title":"Arch Dermatol Res"},{"key":"1999_CR197","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1016\/j.jaad.2021.07.078","volume":"86","author":"N Sutaria","year":"2022","unstructured":"Sutaria N et al (2022) Itch: pathogenesis and treatment. J Am Acad Dermatol 86:17\u201334","journal-title":"J Am Acad Dermatol"},{"key":"1999_CR198","first-page":"91","volume-title":"Medicinal and Nutritional Importance of Aloe barbadensis Miller in Human Health Medicinal Plants and their Bioactive Compounds in Human Health","author":"JCS Swaraj","year":"2024","unstructured":"Swaraj JCS (2024) Medicinal and Nutritional Importance of Aloe barbadensis Miller in Human Health Medicinal Plants and their Bioactive Compounds in Human Health, vol 1. Springer, Cham, pp 91\u2013105"},{"key":"1999_CR199","doi-asserted-by":"publisher","first-page":"124","DOI":"10.1159\/000446055","volume":"50","author":"JC Szepietowski","year":"2016","unstructured":"Szepietowski JC, Reszke R (2016) Psychogenic itch management. Itch Manag Clin Pract 50:124\u2013132","journal-title":"Itch Manag Clin Pract"},{"key":"1999_CR200","doi-asserted-by":"publisher","first-page":"745658","DOI":"10.3389\/fphar.2022.745658","volume":"13","author":"AG Sz\u00f6ll\u0151si","year":"2022","unstructured":"Sz\u00f6ll\u0151si AG, Ol\u00e1h A, Lisztes E, Griger Z, T\u00f3th BI (2022) Pruritus: a sensory symptom generated in cutaneous immuno-neuronal crosstalk. Front Pharmacol 13:745658","journal-title":"Front Pharmacol"},{"key":"1999_CR201","first-page":"1","volume":"25","author":"H Takkunen","year":"1976","unstructured":"Takkunen H (1976) Iron deficiency in the Finnish adult population. Scand J Haematol Suppl 25:1\u201391","journal-title":"Scand J Haematol Suppl"},{"key":"1999_CR202","doi-asserted-by":"publisher","unstructured":"Tang Y et al (2022) Acupuncture for the treatment of itch: peripheral and central mechanisms. Front Neurosci 15:786892. https:\/\/doi.org\/10.3389\/fnins.2021.786892","DOI":"10.3389\/fnins.2021.786892"},{"key":"1999_CR204","doi-asserted-by":"publisher","first-page":"617","DOI":"10.1159\/000188949","volume":"72","author":"D-C Tarng","year":"1996","unstructured":"Tarng D-C, Cho Y-L, Liu H-N, Huang T-P (1996) Hemodialysis-related pruritus: a double-blind, placebo-controlled, crossover study of capsaicin 0.025% cream. Nephron 72:617\u2013622","journal-title":"Nephron"},{"key":"1999_CR205","doi-asserted-by":"publisher","first-page":"652","DOI":"10.3109\/09513590.2011.650764","volume":"28","author":"C Tedeschi","year":"2012","unstructured":"Tedeschi C, Benvenuti C, EG RG (2012) Comparison of vaginal gel isoflavones versus no topical treatment in vaginal dystrophy: results of a preliminary prospective study. Gynecol Endocrinol 28:652\u2013654","journal-title":"Gynecol Endocrinol"},{"key":"1999_CR206","doi-asserted-by":"publisher","first-page":"1873","DOI":"10.3389\/fimmu.2018.01873","volume":"9","author":"EB Thangam","year":"2018","unstructured":"Thangam EB et al (2018) The role of histamine and histamine receptors in mast cell-mediated allergy and inflammation: the hunt for new therapeutic targets. Front Immunol 9:1873","journal-title":"Front Immunol"},{"key":"1999_CR207","doi-asserted-by":"publisher","first-page":"108","DOI":"10.3390\/antiox7080108","volume":"7","author":"M Timoszuk","year":"2018","unstructured":"Timoszuk M, Bielawska K, Skrzydlewska E (2018) Evening primrose (Oenothera biennis) biological activity dependent on chemical composition. Antioxidants 7:108","journal-title":"Antioxidants"},{"key":"1999_CR208","first-page":"111","volume":"21","author":"A Tran","year":"2010","unstructured":"Tran A, Pratt M, DeKoven J (2010) Acute allergic contact dermatitis of the lips from peppermint oil in a lip balm. DERM 21:111\u2013115","journal-title":"DERM"},{"key":"1999_CR209","doi-asserted-by":"publisher","first-page":"1783","DOI":"10.1007\/s12272-009-2217-7","volume":"32","author":"H-T Trinh","year":"2009","unstructured":"Trinh H-T, Bae E-A, Lee JJ, Kim D-H (2009) Inhibitory effects of curcuminoids on passive cutaneous anaphylaxis reaction and scratching behavior in mice. Arch Pharm Res 32:1783\u20131787","journal-title":"Arch Pharm Res"},{"key":"1999_CR210","doi-asserted-by":"publisher","first-page":"4431","DOI":"10.3390\/jcm11154431","volume":"11","author":"A Tsiogka","year":"2022","unstructured":"Tsiogka A et al (2022) The JAK\/STAT pathway and its selective inhibition in the treatment of atopic dermatitis: a systematic review. J Clin Med 11:4431","journal-title":"J Clin Med"},{"key":"1999_CR211","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1186\/s13601-018-0234-7","volume":"8","author":"P Tuchinda","year":"2018","unstructured":"Tuchinda P, Kulthanan K, Chularojanamontri L, Arunkajohnsak S, Sriussadaporn S (2018) Relationship between vitamin D and chronic spontaneous urticaria: a systematic review. Clin Transl Allergy 8:51","journal-title":"Clin Transl Allergy"},{"key":"1999_CR212","doi-asserted-by":"publisher","first-page":"3671","DOI":"10.3390\/ijms22073671","volume":"22","author":"M Ulanowska","year":"2021","unstructured":"Ulanowska M, Olas B (2021) Biological properties and prospects for the application of eugenol\u2014a review. Int J Mol Sci 22:3671","journal-title":"Int J Mol Sci"},{"key":"1999_CR213","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1159\/000485132","volume":"31","author":"M Umar","year":"2018","unstructured":"Umar M et al (2018) Vitamin D and the pathophysiology of inflammatory skin diseases. Skin Pharmacol Physiol 31:74\u201386","journal-title":"Skin Pharmacol Physiol"},{"key":"1999_CR214","doi-asserted-by":"publisher","first-page":"669","DOI":"10.1016\/j.ejphar.2016.10.005","volume":"791","author":"M Vaia","year":"2016","unstructured":"Vaia M et al (2016) Palmitoylethanolamide reduces inflammation and itch in a mouse model of contact allergic dermatitis. Eur J Pharmacol 791:669\u2013674","journal-title":"Eur J Pharmacol"},{"key":"1999_CR215","doi-asserted-by":"publisher","first-page":"385","DOI":"10.2340\/00015555-2524","volume":"97","author":"R Valdes-Rodriguez","year":"2017","unstructured":"Valdes-Rodriguez R et al (2017) Chronic pruritus in primary Sj\u00f6gren\u2019s syndrome: characteristics and effect on quality of life. Acta Dermato-Venereol 97:385\u2013386","journal-title":"Acta Dermato-Venereol"},{"issue":"607\u2013612","key":"1999_CR216","first-page":"e609","volume":"130","author":"P Valent","year":"2012","unstructured":"Valent P et al (2012) Contemporary consensus proposal on criteria and classification of eosinophilic disorders and related syndromes. J Allergy Clin Immunol 130(607\u2013612):e609","journal-title":"J Allergy Clin Immunol"},{"key":"1999_CR217","doi-asserted-by":"publisher","first-page":"108355","DOI":"10.1016\/j.pharmthera.2023.108355","volume":"243","author":"A Vander Does","year":"2023","unstructured":"Vander Does A, Ju T, Mohsin N, Chopra D, Yosipovitch G (2023) How to get rid of itching. Pharmacol Ther 243:108355","journal-title":"Pharmacol Ther"},{"key":"1999_CR218","doi-asserted-by":"publisher","first-page":"706836","DOI":"10.3389\/fphar.2021.706836","volume":"12","author":"W Wang","year":"2021","unstructured":"Wang W et al (2021) The mechanism action of German chamomile (Matricaria recutita L.) in the treatment of eczema: based on dose\u2013effect weight coefficient network pharmacology. Front Pharmacol 12:706836","journal-title":"Front Pharmacol"},{"key":"1999_CR219","doi-asserted-by":"publisher","DOI":"10.2147\/CCID.S391741","author":"F Wang","year":"2023","unstructured":"Wang F et al (2023) Aloe extracts inhibit skin inflammatory responses by regulating NF-\u03baB, ERK, and JNK signaling pathways in an LPS-induced RAW264. 7 macrophages model. Clin Cosmet Investig Dermatol. https:\/\/doi.org\/10.2147\/CCID.S391741","journal-title":"Clin Cosmet Investig Dermatol"},{"key":"1999_CR220","doi-asserted-by":"publisher","first-page":"1744","DOI":"10.1186\/1744-8069-7-11","volume":"7","author":"W Wang","year":"2011","unstructured":"Wang W et al (2011) Preserved acute pain and impaired neuropathic pain in mice lacking protein interacting with C Kinase 1. Mol Pain 7:1744\u20138069","journal-title":"Mol Pain"},{"key":"1999_CR221","first-page":"589","volume":"13","author":"TM Weber","year":"2014","unstructured":"Weber TM et al (2014) Steroid-free emollient formulations reduce symptoms of eczema and improve quality of life. J Drug Dermatol 13:589\u2013595","journal-title":"J Drug Dermatol"},{"key":"1999_CR222","doi-asserted-by":"publisher","first-page":"640","DOI":"10.1016\/j.jdcr.2018.03.025","volume":"4","author":"BD Weinberg","year":"2018","unstructured":"Weinberg BD, Amans M, Deviren S, Berger T, Shah V (2018) Brachioradial pruritus treated with computed tomography-guided cervical nerve root block: a case series. JAAD Case Rep 4:640\u2013644","journal-title":"JAAD Case Rep"},{"key":"1999_CR223","doi-asserted-by":"publisher","first-page":"2","DOI":"10.15171\/ijpni.2016.02","volume":"3","author":"IE Weir","year":"2016","unstructured":"Weir IE, Molina JP, Carson S (2016) A clinical trial with AtopisTM cream for the treatment of mild to moderate eczema. Int J Phytocosmet Nat Ingred 3:2\u20132","journal-title":"Int J Phytocosmet Nat Ingred"},{"key":"1999_CR224","doi-asserted-by":"publisher","first-page":"339","DOI":"10.2340\/00015555-0662","volume":"89","author":"E Weisshaar","year":"2009","unstructured":"Weisshaar E, Dalgard F (2009) Epidemiology of itch: adding to the burden of skin morbidity. Acta Derm Venereol 89:339\u2013350","journal-title":"Acta Derm Venereol"},{"key":"1999_CR225","doi-asserted-by":"publisher","first-page":"e33805","DOI":"10.1371\/journal.pone.0033805","volume":"7","author":"Z Weng","year":"2012","unstructured":"Weng Z et al (2012) Quercetin is more effective than cromolyn in blocking human mast cell cytokine release and inhibits contact dermatitis and photosensitivity in humans. PLoS ONE 7:e33805","journal-title":"PLoS ONE"},{"key":"1999_CR226","doi-asserted-by":"publisher","first-page":"478","DOI":"10.1038\/nri3690","volume":"14","author":"S Wernersson","year":"2014","unstructured":"Wernersson S, Pejler G (2014) Mast cell secretory granules: armed for battle. Nat Rev Immunol 14:478\u2013494","journal-title":"Nat Rev Immunol"},{"key":"1999_CR227","doi-asserted-by":"publisher","first-page":"285","DOI":"10.1016\/j.cell.2013.08.057","volume":"155","author":"SR Wilson","year":"2013","unstructured":"Wilson SR et al (2013) The epithelial cell-derived atopic dermatitis cytokine TSLP activates neurons to induce itch. Cell 155:285\u2013295","journal-title":"Cell"},{"key":"1999_CR228","doi-asserted-by":"publisher","first-page":"1166","DOI":"10.3390\/biom11081166","volume":"11","author":"J Wilzopolski","year":"2021","unstructured":"Wilzopolski J et al (2021) TRPV1 and TRPA1 channels are both involved downstream of histamine-induced itch. Biomolecules 11:1166","journal-title":"Biomolecules"},{"key":"1999_CR229","doi-asserted-by":"publisher","first-page":"1485","DOI":"10.3390\/ijms18071485","volume":"18","author":"L-S Wong","year":"2017","unstructured":"Wong L-S, Wu T, Lee C-H (2017) Inflammatory and noninflammatory itch: implications in pathophysiology-directed treatments. Int J Mol Sci 18:1485","journal-title":"Int J Mol Sci"},{"key":"1999_CR230","doi-asserted-by":"publisher","first-page":"111741","DOI":"10.1016\/j.biopha.2021.111741","volume":"140","author":"S Wu","year":"2021","unstructured":"Wu S et al (2021) A comprehensive review of natural products against atopic dermatitis: Flavonoids, alkaloids, terpenes, glycosides and other compounds. Biomed Pharmacother 140:111741","journal-title":"Biomed Pharmacother"},{"key":"1999_CR231","first-page":"995","volume":"18","author":"A Yahya","year":"2019","unstructured":"Yahya A (2019) Characterizing pruritus in autoimmune connective tissue diseases. J Drug Dermatol 18:995\u2013998","journal-title":"J Drug Dermatol"},{"key":"1999_CR232","first-page":"255","volume":"5","author":"YF Yahya","year":"2021","unstructured":"Yahya YF et al (2021) The efficacy and safety of plant oil mixtures in the treatment of xerosis with pruritus in elderly people: randomized double blind controlled trial. Bioscientia Medicina J Biomed Transl Res 5:255\u2013262","journal-title":"Bioscientia Medicina J Biomed Transl Res"},{"issue":"5","key":"1999_CR233","doi-asserted-by":"publisher","first-page":"395","DOI":"10.1248\/jhs1956.39.5_395","volume":"39","author":"M Yamamoto","year":"1993","unstructured":"Yamamoto M et al (1993) Inhibitory effects of aloe extracts on antigen-and compound 48\/80-induced histamine release from rat peritoneal mast cells. Eisei Kagaku 39(5):395\u2013400","journal-title":"Eisei Kagaku"},{"key":"1999_CR234","doi-asserted-by":"publisher","first-page":"107620","DOI":"10.1016\/j.intimp.2021.107620","volume":"96","author":"C-C Yang","year":"2021","unstructured":"Yang C-C et al (2021) Quercetin inhibits histamine-induced calcium influx in human keratinocyte via histamine H4 receptors. Int Immunopharmacol 96:107620","journal-title":"Int Immunopharmacol"},{"key":"1999_CR235","doi-asserted-by":"publisher","first-page":"106902","DOI":"10.1016\/j.imlet.2024.106902","volume":"270","author":"Y Yang","year":"2024","unstructured":"Yang Y et al (2024) Aloe-emodin relieves allergic contact dermatitis pruritus by inhibiting mast cell degranulation. Immunol Lett 270:106902","journal-title":"Immunol Lett"},{"key":"1999_CR236","doi-asserted-by":"publisher","first-page":"eadd1268","DOI":"10.1126\/science.add1268","volume":"378","author":"Y Yin","year":"2022","unstructured":"Yin Y et al (2022) Activation mechanism of the mouse cold-sensing TRPM8 channel by cooling agonist and PIP2. Science 378:eadd1268","journal-title":"Science"},{"key":"1999_CR237","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1111\/j.1529-8019.2008.00167.x","volume":"21","author":"G Yosipovitch","year":"2008","unstructured":"Yosipovitch G, Samuel LS (2008) Neuropathic and psychogenic itch. Dermatol Ther 21:32\u201341","journal-title":"Dermatol Ther"},{"key":"1999_CR238","doi-asserted-by":"publisher","first-page":"1375","DOI":"10.1016\/j.jaci.2018.09.005","volume":"142","author":"G Yosipovitch","year":"2018","unstructured":"Yosipovitch G et al (2018a) Itch: from mechanism to (novel) therapeutic approaches. J Allergy Clin Immunol 142:1375\u20131390","journal-title":"J Allergy Clin Immunol"},{"key":"1999_CR239","doi-asserted-by":"publisher","first-page":"1375","DOI":"10.1016\/j.jaci.2018.09.005","volume":"142","author":"G Yosipovitch","year":"2018","unstructured":"Yosipovitch G, Rosen JD, Hashimoto T (2018b) Itch: from mechanism to (novel) therapeutic approaches. J Allergy Clin Immunol 142:1375\u20131390","journal-title":"J Allergy Clin Immunol"},{"key":"1999_CR240","doi-asserted-by":"publisher","DOI":"10.1093\/bjd\/ljae260","author":"G Yosipovitch","year":"2024","unstructured":"Yosipovitch G et al (2024) International study on prevalence of itch: examining the role of itch as a major global public health problem. Br J Dermatol. https:\/\/doi.org\/10.1093\/bjd\/ljae260","journal-title":"Br J Dermatol"},{"key":"1999_CR241","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1002\/cia2.12049","volume":"2","author":"S Yu","year":"2019","unstructured":"Yu S, Li Y, Zhou Y, Follansbee T, Hwang ST (2019) Immune mediators and therapies for pruritus in atopic dermatitis and psoriasis. J Cutan Immunol Allergy 2:4\u201314","journal-title":"J Cutan Immunol Allergy"},{"key":"1999_CR242","doi-asserted-by":"publisher","first-page":"1071","DOI":"10.3390\/antiox11061071","volume":"11","author":"Y Zhang","year":"2022","unstructured":"Zhang Y et al (2022) Skin care product rich in antioxidants and anti-inflammatory natural compounds reduces itching and inflammation in the skin of atopic dermatitis patients. Antioxidants 11:1071","journal-title":"Antioxidants"},{"key":"1999_CR243","doi-asserted-by":"publisher","first-page":"821","DOI":"10.1016\/j.neuron.2014.10.003","volume":"84","author":"Z-Q Zhao","year":"2014","unstructured":"Zhao Z-Q et al (2014) Descending control of itch transmission by the serotonergic system via 5-HT1A-facilitated GRP-GRPR signaling. Neuron 84:821\u2013834","journal-title":"Neuron"}],"container-title":["Inflammopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10787-025-01999-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10787-025-01999-1\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10787-025-01999-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,18]],"date-time":"2025-12-18T11:05:40Z","timestamp":1766055940000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10787-025-01999-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10,30]]},"references-count":242,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2025,12]]}},"alternative-id":["1999"],"URL":"https:\/\/doi.org\/10.1007\/s10787-025-01999-1","relation":{},"ISSN":["0925-4692","1568-5608"],"issn-type":[{"value":"0925-4692","type":"print"},{"value":"1568-5608","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,10,30]]},"assertion":[{"value":"17 August 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 September 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 October 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}},{"value":"Not applicable.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to publish"}}]}}