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This study intended to characterize\n                    <jats:italic>C. tetragona<\/jats:italic>\n                    aerial parts\u2019 phytoconstituents and assess its anti-ulcerative potential via the PPAR\u03b3\/SIRT1 pathway. Aerial parts of\n                    <jats:italic>C. tetragona<\/jats:italic>\n                    were extracted using n-hexane (CT1) and 70% aqueous methanol (CT2). Phytoconstituents were profiled by HPLC\u2013ESI\u2013MS\/MS (negative ion mode), and phenolics were quantified by MRM-LC\u2013ESI\u2013MS\/MS. Column chromatography and NMR were used to separate and identify the compounds. Ulcerative colitis (UC) was induced in rats by intrarectal acetic acid (AA). Animals were assigned into six groups: control group: orally received vehicle for 7\u00a0days, UC control group: orally received vehicle for 7\u00a0days, and a rectal infusion of 2\u00a0mL AA (4% v\/v in saline) on the 8th day, 4 treated groups: received CT1 (200 and 400\u00a0mg\/kg\/day), or received CT2 (200 and 400\u00a0mg\/kg\/day), once daily for 7\u00a0days by oral gavage and 2\u00a0mL AA (4% v\/v in saline) on the 8th day. HPLC\u2013ESI\u2013MS\/MS identified 66 constituents, including 37 novel compounds, with CT2 exhibiting higher phenolic content. Naringenin, gallic acid, and quercetin were predominant. Five phenolic compounds were isolated from the bioactive extract CT2. Both CT1 and CT2 reduced AA-induced tissue damage, lowered inflammatory markers (calprotectin, CRP, TNF-\u03b1, IL-6), improved oxidative stress (reduced MDA, increased GSH, SOD), and upregulated SIRT1 and PPAR\u03b3. These results suggest\n                    <jats:italic>C. tetragona<\/jats:italic>\n                    attenuates UC via the SIRT1\/PPAR\u03b3 pathway, indicating its therapeutic potential.\n                  <\/jats:p>","DOI":"10.1007\/s10787-025-02049-6","type":"journal-article","created":{"date-parts":[[2025,12,6]],"date-time":"2025-12-06T05:04:13Z","timestamp":1764997453000},"page":"707-727","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Unveiling phytoconstituents and the anti-inflammatory potential of Crassula tetragona L. in ulcerative colitis: A focus on the PPAR\u03b3\/SIRT1 axis"],"prefix":"10.1007","volume":"34","author":[{"given":"Mona A.","family":"Raslan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rehab F.","family":"Abdel-Rahman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hany M.","family":"Fayed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marawan A.","family":"Elbaset","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rehab F.","family":"Taher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,12,6]]},"reference":[{"key":"2049_CR1","doi-asserted-by":"publisher","first-page":"1239025","DOI":"10.3389\/fphar.2023.1239025","volume":"14","author":"R Abdelhady","year":"2023","unstructured":"Abdelhady R, Saber S, Ahmed Abdel-Reheim M et al (2023) Unveiling the therapeutic potential of exogenous \u03b2-hydroxybutyrate for chronic colitis in rats: novel insights on autophagy, apoptosis, and pyroptosis. 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