{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T14:41:53Z","timestamp":1790347313422,"version":"4.1.0"},"reference-count":42,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,12,15]],"date-time":"2025-12-15T00:00:00Z","timestamp":1765756800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,12,15]],"date-time":"2025-12-15T00:00:00Z","timestamp":1765756800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Inflammopharmacol"],"published-print":{"date-parts":[[2026,1]]},"DOI":"10.1007\/s10787-025-02064-7","type":"journal-article","created":{"date-parts":[[2025,12,15]],"date-time":"2025-12-15T14:49:26Z","timestamp":1765810166000},"page":"473-483","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Fluvoxamine attenuates inflammation in experimental sepsis via novel non-canonical pathways"],"prefix":"10.1007","volume":"34","author":[{"given":"Luis H. A.","family":"Costa","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isis P.","family":"Trajano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wanderson S.","family":"Santos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katiuscia M.","family":"Ara\u00fajo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0292-4947","authenticated-orcid":false,"given":"Luiz G. S.","family":"Branco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,12,15]]},"reference":[{"issue":"12","key":"2064_CR1","doi-asserted-by":"publisher","first-page":"934","DOI":"10.1001\/jama.1995.03520360048038","volume":"273","author":"E Abraham","year":"1995","unstructured":"Abraham E, Wunderink R, Silverman H et al (1995) Efficacy and safety of monoclonal antibody to human tumor necrosis factor \u03b1 in patients with sepsis syndrome: a randomized, controlled, double-blind, multicenter clinical trial. JAMA J Am Med Assoc 273(12):934\u2013941. https:\/\/doi.org\/10.1001\/jama.1995.03520360048038","journal-title":"JAMA J Am Med Assoc"},{"key":"2064_CR2","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1186\/2110-5820-1-7","volume":"1","author":"D Annane","year":"2011","unstructured":"Annane D (2011) Corticosteroids for severe sepsis: an evidence-based guide for physicians. Ann Intensive Care 1:7. https:\/\/doi.org\/10.1186\/2110-5820-1-7","journal-title":"Ann Intensive Care"},{"key":"2064_CR3","doi-asserted-by":"publisher","first-page":"428","DOI":"10.1016\/S0893-133X(00)00116-0","volume":"23","author":"NR Bolo","year":"2000","unstructured":"Bolo NR, Hod\u00e9 Y, N\u00e9d\u00e9lec JF et al (2000) Brain pharmacokinetics and tissue distribution in vivo of fluvoxamine and fluoxetine by fluorine magnetic resonance spectroscopy. Neuropsychopharmacology 23:428\u2013438. https:\/\/doi.org\/10.1016\/S0893-133X(00)00116-0","journal-title":"Neuropsychopharmacology"},{"key":"2064_CR4","doi-asserted-by":"publisher","first-page":"5951","DOI":"10.1096\/fj.201901921R","volume":"34","author":"I Bravo-Caparr\u00f3s","year":"2020","unstructured":"Bravo-Caparr\u00f3s I, Ruiz-Cantero MC, Perazzoli G et al (2020) Sigma-1 receptors control neuropathic pain and macrophage infiltration into the dorsal root ganglion after peripheral nerve injury. FASEB J 34:5951\u20135966. https:\/\/doi.org\/10.1096\/fj.201901921R","journal-title":"FASEB J"},{"key":"2064_CR5","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1038\/nri.2017.1","volume":"17","author":"DW Cain","year":"2017","unstructured":"Cain DW, Cidlowski JA (2017) Nat Rev Immunol 17:233\u2013247. https:\/\/doi.org\/10.1038\/nri.2017.1","journal-title":"Nat Rev Immunol"},{"key":"2064_CR6","unstructured":"Center for Drug Evaluation and Research (2005) Guidance for industry: estimating the maximum safe starting dose in initial clinical trials for therapeutics in adult healthy volunteers. US Department of Health and Human Services"},{"key":"2064_CR40","doi-asserted-by":"publisher","first-page":"100","DOI":"10.1016\/j.ejphar.2020.173629","volume":"12","author":"LHA Costa","year":"2020","unstructured":"Costa LHA, Santos BM, Branco LGS (2020) Can selective serotonin reuptake inhibitors have a neuroprotective effect during COVID-19? Eur J Pharmacol 889:173629. https:\/\/doi.org\/10.1016\/j.ejphar.2020.173629","journal-title":"European Journal of Pharmacology"},{"key":"2064_CR7","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneuroim.2024.578427","volume":"394","author":"RA Costa","year":"2024","unstructured":"Costa RA, Amatnecks JA, de Oliveira Guaita G et al (2024) Sexual dimorphism of hypothalamic serotonin release during systemic inflammation: role of endothelin-1. J Neuroimmunol 394:578427. https:\/\/doi.org\/10.1016\/j.jneuroim.2024.578427","journal-title":"J Neuroimmunol"},{"key":"2064_CR8","doi-asserted-by":"publisher","first-page":"2672","DOI":"10.1007\/s12035-023-03717-w","volume":"61","author":"S Denaro","year":"2024","unstructured":"Denaro S, Pasquinucci L, Turnaturi R et al (2024) Sigma-1 receptor inhibition reduces mechanical allodynia and modulate neuroinflammation in chronic neuropathic pain. Mol Neurobiol 61:2672\u20132685. https:\/\/doi.org\/10.1007\/s12035-023-03717-w","journal-title":"Mol Neurobiol"},{"key":"2064_CR9","doi-asserted-by":"publisher","first-page":"1836","DOI":"10.1001\/jama.271.23.1836","volume":"271","author":"CJ Fisher","year":"1994","unstructured":"Fisher CJ, Dhainaut JA, Opal SM (1994) Recombinant human interleukin 1 receptor antagonist in the treatment of patients with sepsis syndrome. Results from a randomized, double-blind, placebo-controlled trial. Phase III rhIL-1ra Sepsis Syndrome Study Group. JAMA 271:1836\u20131843. https:\/\/doi.org\/10.1001\/jama.271.23.1836","journal-title":"JAMA"},{"key":"2064_CR10","doi-asserted-by":"publisher","first-page":"1826","DOI":"10.1007\/s00134-018-5377-4","volume":"44","author":"C Fleischmann-Struzek","year":"2018","unstructured":"Fleischmann-Struzek C, Mikolajetz A, Schwarzkopf D et al (2018) Challenges in assessing the burden of sepsis and understanding the inequalities of sepsis outcomes between National Health Systems: secular trends in sepsis and infection incidence and mortality in Germany. Intensive Care Med 44:1826\u20131835. https:\/\/doi.org\/10.1007\/s00134-018-5377-4","journal-title":"Intensive Care Med"},{"key":"2064_CR11","doi-asserted-by":"publisher","first-page":"1169","DOI":"10.1007\/s001340100973","volume":"27","author":"J Gallagher","year":"2001","unstructured":"Gallagher J, Fisher C, Sherman B et al (2001) A multicenter, open-label, prospective, randomized, dose-ranging pharmacokinetic study of the anti-TNF-\u03b1 antibody afelimomab in patients with sepsis syndrome. Intensive Care Med 27:1169\u20131178. https:\/\/doi.org\/10.1007\/s001340100973","journal-title":"Intensive Care Med"},{"key":"2064_CR41","doi-asserted-by":"publisher","unstructured":"Gallant RM, Sanchez KK, Joulia E et al (2025) Fluoxetine promotes IL-10\u2013dependent metabolic defenses to protect from sepsis-induced lethality. Sci Adv 11:eadu4034. https:\/\/doi.org\/10.1126\/sciadv.adu4034","DOI":"10.1126\/sciadv.adu4034"},{"key":"2064_CR12","doi-asserted-by":"publisher","first-page":"1183","DOI":"10.1590\/S1807-59322010001100022","volume":"65","author":"V Hajhashemi","year":"2010","unstructured":"Hajhashemi V, Sadeghi H, Minaiyan M et al (2010) The role of central mechanisms in the anti-inflammatory effect of amitriptyline on carrageenan-induced paw edema in rats. Clinics 65:1183\u20131187. https:\/\/doi.org\/10.1590\/S1807-59322010001100022","journal-title":"Clinics"},{"key":"2064_CR13","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.2017.00048","author":"N Herr","year":"2017","unstructured":"Herr N, Bode C, Duerschmied D (2017) The effects of serotonin in immune cells. Front Cardiovasc Med. https:\/\/doi.org\/10.3389\/fcvm.2017.00048","journal-title":"Front Cardiovasc Med"},{"key":"2064_CR14","doi-asserted-by":"publisher","first-page":"2472","DOI":"10.1016\/j.immuni.2023.10.008","volume":"56","author":"JP Hoffmann","year":"2023","unstructured":"Hoffmann JP, Liu JA, Seddu K, Klein SL (2023) Sex hormone signaling and regulation of immune function. Immunity 56:2472\u20132491. https:\/\/doi.org\/10.1016\/j.immuni.2023.10.008","journal-title":"Immunity"},{"key":"2064_CR15","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1016\/j.bbrc.2010.01.066","volume":"393","author":"KR Kasten","year":"2010","unstructured":"Kasten KR, Muenzer JT, Caldwell CC (2010) Neutrophils are significant producers of IL-10 during sepsis. Biochem Biophys Res Commun 393:28\u201331. https:\/\/doi.org\/10.1016\/j.bbrc.2010.01.066","journal-title":"Biochem Biophys Res Commun"},{"key":"2064_CR16","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1016\/j.neulet.2015.05.058","volume":"600","author":"JM Kim","year":"2015","unstructured":"Kim JM, Jeong SW, Yang J et al (2015) Spinal 5-HT1A, not the 5-HT1B or 5-HT3 receptors, mediates descending serotonergic inhibition for late-phase mechanical allodynia of carrageenan-induced peripheral inflammation. Neurosci Lett 600:91\u201397. https:\/\/doi.org\/10.1016\/j.neulet.2015.05.058","journal-title":"Neurosci Lett"},{"key":"2064_CR17","doi-asserted-by":"publisher","first-page":"5411","DOI":"10.1038\/s41380-023-02004-3","volume":"28","author":"BJ Kirenga","year":"2023","unstructured":"Kirenga BJ, Mugenyi L, S\u00e1nchez-Rico M et al (2023) Association of fluvoxamine with mortality and symptom resolution among inpatients with COVID-19 in Uganda: a prospective interventional open-label cohort study. Mol Psychiatry 28:5411\u20135418. https:\/\/doi.org\/10.1038\/s41380-023-02004-3","journal-title":"Mol Psychiatry"},{"key":"2064_CR18","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1177\/1721727X15618671","volume":"13","author":"I Kostadinov","year":"2015","unstructured":"Kostadinov I, Delev D, Petrova M et al (2015) Study on anti-inflammatory and immunomodulatory effects of fluoxetine in rat models of inflammation. Eur J Inflamm 13:173\u2013182. https:\/\/doi.org\/10.1177\/1721727X15618671","journal-title":"Eur J Inflamm"},{"key":"2064_CR19","doi-asserted-by":"publisher","first-page":"762","DOI":"10.1016\/j.tins.2012.09.007","volume":"35","author":"S Kourrich","year":"2012","unstructured":"Kourrich S, Su TP, Fujimoto M, Bonci A (2012) The sigma-1 receptor: roles in neuronal plasticity and disease. Trends Neurosci 35:762\u2013771. https:\/\/doi.org\/10.1016\/j.tins.2012.09.007","journal-title":"Trends Neurosci"},{"key":"2064_CR20","doi-asserted-by":"publisher","first-page":"2292","DOI":"10.1001\/jama.2020.22760","volume":"324","author":"EJ Lenze","year":"2020","unstructured":"Lenze EJ, Mattar C, Zorumski CF et al (2020) Fluvoxamine vs placebo and clinical deterioration in outpatients with symptomatic COVID-19: a randomized clinical trial. JAMA 324:2292\u20132300. https:\/\/doi.org\/10.1001\/jama.2020.22760","journal-title":"JAMA"},{"key":"2064_CR21","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1097\/01.CCM.0000105581.01815.C6","volume":"32","author":"A L\u00f3pez","year":"2004","unstructured":"L\u00f3pez A, Lorente JA, Steingrub J et al (2004) Multiple-center, randomized, placebo-controlled, double-blind study of the nitric oxide synthase inhibitor 546C88: effect on survival in patients with septic shock. Crit Care Med 32:21\u201330. https:\/\/doi.org\/10.1097\/01.CCM.0000105581.01815.C6","journal-title":"Crit Care Med"},{"key":"2064_CR22","doi-asserted-by":"publisher","DOI":"10.1186\/s10020-019-0132-z","volume":"26","author":"Z Mostel","year":"2019","unstructured":"Mostel Z, Perl A, Marck M et al (2019) Post-sepsis syndrome- a n evolving entity that afflicts survivors of sepsis. Mol Med 26:6. https:\/\/doi.org\/10.1186\/s10020-019-0132-z","journal-title":"Mol Med"},{"key":"2064_CR23","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1016\/j.bbi.2019.03.017","volume":"80","author":"CMD Mota","year":"2019","unstructured":"Mota CMD, Borges GS, Amorim MR et al (2019) Central serotonin prevents hypotension and hypothermia and reduces plasma and spleen cytokine levels during systemic inflammation. Brain Behav Immun 80:255\u2013265. https:\/\/doi.org\/10.1016\/j.bbi.2019.03.017","journal-title":"Brain Behav Immun"},{"key":"2064_CR24","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1016\/0014-2999(96)00254-3","volume":"307","author":"N Narita","year":"1996","unstructured":"Narita N, Hashimoto K, Tomitaka SI, Minabe Y (1996) Interactions of selective serotonin reuptake inhibitors with subtypes of \u03c3 receptors in rat brain. Eur J Pharmacol 307:117\u2013119. https:\/\/doi.org\/10.1016\/0014-2999(96)00254-3","journal-title":"Eur J Pharmacol"},{"key":"2064_CR25","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1055\/a-1686-9620","volume":"55","author":"MJ Nykamp","year":"2022","unstructured":"Nykamp MJ, Zorumski CF, Reiersen AM et al (2022) Opportunities for drug repurposing of serotonin reuptake inhibitors: potential uses in inflammation, infection, cancer, neuroprotection, and Alzheimer\u2019s disease prevention. Pharmacopsychiatry 55:24\u201329. https:\/\/doi.org\/10.1055\/a-1686-9620","journal-title":"Pharmacopsychiatry"},{"key":"2064_CR26","doi-asserted-by":"publisher","first-page":"1115","DOI":"10.1097\/00003246-199707000-00010","volume":"25","author":"SM Opal","year":"1997","unstructured":"Opal SM, Fisher CJ, Dhainaut JFA et al (1997) Confirmatory interleukin-1 receptor antagonist trial in severe sepsis: A phase III, randomized, double-blind, placebo-controlled, multicenter trial. Crit Care Med 25:1115\u20131124. https:\/\/doi.org\/10.1097\/00003246-199707000-00010","journal-title":"Crit Care Med"},{"key":"2064_CR27","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1016\/j.bbi.2024.03.037","volume":"119","author":"P Passaglia","year":"2024","unstructured":"Passaglia P, Kanashiro A, Batista Silva H et al (2024) Diminazene aceturate attenuates systemic inflammation via microbiota gut-5-HT brain-spleen sympathetic axis in male mice. Brain Behav Immun 119:105\u2013119. https:\/\/doi.org\/10.1016\/j.bbi.2024.03.037","journal-title":"Brain Behav Immun"},{"key":"2064_CR28","doi-asserted-by":"publisher","first-page":"1039379","DOI":"10.3389\/fnins.2022.1039379","volume":"16","author":"S Patel","year":"2023","unstructured":"Patel S, Keating BA, Dale RC (2023) Anti-inflammatory properties of commonly used psychiatric drugs. Front Neurosci 16:1039379. https:\/\/doi.org\/10.3389\/fnins.2022.1039379","journal-title":"Front Neurosci"},{"key":"2064_CR29","doi-asserted-by":"publisher","first-page":"e42","DOI":"10.1016\/S2214-109X(21)00448-4","volume":"10","author":"G Reis","year":"2022","unstructured":"Reis G, dos Santos Moreira-Silva EA, Silva DCM et al (2022) Effect of early treatment with fluvoxamine on risk of emergency care and hospitalisation among patients with COVID-19: the TOGETHER randomised, platform clinical trial. Lancet Glob Health 10:e42\u2013e51. https:\/\/doi.org\/10.1016\/S2214-109X(21)00448-4","journal-title":"Lancet Glob Health"},{"key":"2064_CR30","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2018.7571","volume":"2","author":"C Rhee","year":"2019","unstructured":"Rhee C, Jones TM, Hamad Y et al (2019) Prevalence, underlying causes, and preventability of sepsis-associated mortality in US acute care hospitals. JAMA Netw Open 2:e187571. https:\/\/doi.org\/10.1001\/jamanetworkopen.2018.7571","journal-title":"JAMA Netw Open"},{"key":"2064_CR31","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aau5266","volume":"11","author":"DA Rosen","year":"2019","unstructured":"Rosen DA, Seki SM, Fern\u00e1ndez-Casta\u00f1eda A et al (2019) Modulation of the sigma-1 receptor-IRE1 pathway is beneficial in preclinical models of inflammation and sepsis. Sci Transl Med 11:eaau5266. https:\/\/doi.org\/10.1126\/scitranslmed.aau5266","journal-title":"Sci Transl Med"},{"key":"2064_CR32","doi-asserted-by":"publisher","first-page":"546","DOI":"10.1111\/jnc.13002","volume":"132","author":"A Shanmugam","year":"2015","unstructured":"Shanmugam A, Wang J, Markand S et al (2015) Sigma receptor 1 activation attenuates release of inflammatory cytokines MIP1\u03b3, MIP2, MIP3\u03b1, and IL12 (p40\/p70) by retinal M\u00fcller glial cells. J Neurochem 132:546\u2013558. https:\/\/doi.org\/10.1111\/jnc.13002","journal-title":"J Neurochem"},{"key":"2064_CR33","doi-asserted-by":"publisher","first-page":"801","DOI":"10.1001\/jama.2016.0287","volume":"315","author":"M Singer","year":"2016","unstructured":"Singer M, Deutschman CS, Seymour C et al (2016) The third international consensus definitions for sepsis and septic shock (sepsis-3). JAMA 315:801\u2013810. https:\/\/doi.org\/10.1001\/jama.2016.0287","journal-title":"JAMA"},{"key":"2064_CR34","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1146\/annurev-pathol-011110-130327","volume":"6","author":"DJ Stearns-Kurosawa","year":"2011","unstructured":"Stearns-Kurosawa DJ, Osuchowski MF, Valentine C et al (2011) The pathogenesis of sepsis. Annu Rev Pathol Mech Dis 6:19\u201348. https:\/\/doi.org\/10.1146\/annurev-pathol-011110-130327","journal-title":"Annu Rev Pathol Mech Dis"},{"key":"2064_CR35","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0106533","volume":"9","author":"A Szabo","year":"2014","unstructured":"Szabo A, Kovacs A, Frecska E, Rajnavolgyi E (2014) Psychedelic N,N-dimethyltryptamine and 5-methoxy-N,N-dimethyltryptamine modulate innate and adaptive inflammatory responses through the sigma-1 receptor of human monocyte-derived dendritic cells. PLoS ONE 9:e106533. https:\/\/doi.org\/10.1371\/journal.pone.0106533","journal-title":"PLoS ONE"},{"key":"2064_CR36","doi-asserted-by":"publisher","first-page":"853","DOI":"10.1038\/nature01321","volume":"420","author":"KJ Tracey","year":"2002","unstructured":"Tracey KJ (2002) The inflammatory reflex. Nature 420:853\u2013859. https:\/\/doi.org\/10.1038\/nature01321","journal-title":"Nature"},{"key":"2064_CR37","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2025.156909","volume":"189","author":"IP Trajano","year":"2025","unstructured":"Trajano IP, Costa LHA, Passaglia P et al (2025) Fluoxetine mitigates hypothermia and inflammatory responses in lipopolysaccharide-induced systemic inflammation: insights into serotonergic and hypothalamic thermoregulatory mechanisms. Cytokine 189:156909. https:\/\/doi.org\/10.1016\/j.cyto.2025.156909","journal-title":"Cytokine"},{"key":"2064_CR38","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2022.104318","volume":"86","author":"JL Vincent","year":"2022","unstructured":"Vincent JL (2022) Current sepsis therapeutics. EBioMedicine 86:104318. https:\/\/doi.org\/10.1016\/j.ebiom.2022.104318","journal-title":"EBioMedicine"},{"key":"2064_CR42","doi-asserted-by":"publisher","first-page":"256","DOI":"10.1016\/j.bbi.2024.06.008","volume":"120","author":"JY Wang","year":"2024","unstructured":"Wang J-Y, Ren P, Cui L-Y et al (2024) Astrocyte-specific activation of sigma-1 receptors in mPFC mediates the faster onset antidepressant effect by inhibiting NF-\u03baB-induced neuroinflammation. Brain Behav Immun 120:256\u2013274. https:\/\/doi.org\/10.1016\/j.bbi.2024.06.008","journal-title":"Brain, Behavior, and Immunity"},{"key":"2064_CR39","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/6374283","volume":"2017","author":"J Zhang","year":"2017","unstructured":"Zhang J, Bi J, Liu S et al (2017) 5-HT drives mortality in sepsis induced by cecal ligation and puncture in mice. Mediators Inflamm 2017:374283. https:\/\/doi.org\/10.1155\/2017\/6374283","journal-title":"Mediators Inflamm"}],"container-title":["Inflammopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10787-025-02064-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10787-025-02064-7","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10787-025-02064-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,29]],"date-time":"2026-01-29T16:26:48Z","timestamp":1769704008000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10787-025-02064-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,15]]},"references-count":42,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["2064"],"URL":"https:\/\/doi.org\/10.1007\/s10787-025-02064-7","relation":{"has-preprint":[{"id-type":"doi","id":"10.21203\/rs.3.rs-7142228\/v1","asserted-by":"object"}]},"ISSN":["0925-4692","1568-5608"],"issn-type":[{"value":"0925-4692","type":"print"},{"value":"1568-5608","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12,15]]},"assertion":[{"value":"16 July 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 November 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 December 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare that they have no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"All experiments were conducted in accordance with the ARRIVE guidelines and approved by the by the Animal Ethical Committee of the Dental School of Ribeir\u00e3o Preto (2020.1.391.58.3).","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"Not applicable.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}}]}}