{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,11]],"date-time":"2026-10-11T19:06:37Z","timestamp":1791745597366,"version":"4.3.4"},"reference-count":291,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,12,8]],"date-time":"2025-12-08T00:00:00Z","timestamp":1765152000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,12,8]],"date-time":"2025-12-08T00:00:00Z","timestamp":1765152000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Inflammopharmacol"],"published-print":{"date-parts":[[2026,1]]},"DOI":"10.1007\/s10787-025-02065-6","type":"journal-article","created":{"date-parts":[[2025,12,8]],"date-time":"2025-12-08T15:20:24Z","timestamp":1765207224000},"page":"91-123","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Phytochemicals and nanoformulation strategies for rheumatoid arthritis: mechanistic insights, therapeutic advances, and translational challenges"],"prefix":"10.1007","volume":"34","author":[{"given":"Mohsen","family":"Rahmanian","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Khosropanah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sepehr Hoseinzadeh","family":"Moghaddam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abulfazl","family":"Vatankhah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali","family":"Haghbin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fatemeh","family":"Oroojalian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kasim Sakran","family":"Abass","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0890-769X","authenticated-orcid":false,"given":"Prashant","family":"Kesharwani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amirhossein","family":"Sahebkar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,12,8]]},"reference":[{"issue":"1","key":"2065_CR1","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1186\/s43166-024-00242-z","volume":"51","author":"MS Abdelrahman","year":"2024","unstructured":"Abdelrahman MS, Shaddad AM, Khaleel WGE, Talaat EA, Safwat SM, Farrag S (2024) Sleep quality, anxiety, depression, and quality of life in rheumatoid arthritis patients and impact of disease activity. Egypt Rheumatol Rehabil 51(1):10","journal-title":"Egypt Rheumatol Rehabil"},{"key":"2065_CR2","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1007\/s00296-002-0234-7","volume":"23","author":"O Adam","year":"2003","unstructured":"Adam O, Beringer C, Kless T, Lemmen C, Adam A, Wiseman M et al (2003) Anti-inflammatory effects of a low arachidonic acid diet and fish oil in patients with rheumatoid arthritis. Rheumatol Int 23:27\u201336","journal-title":"Rheumatol Int"},{"key":"2065_CR3","doi-asserted-by":"publisher","unstructured":"Adedokun KA, Imodoye SO, Bello IO, Lanihun A-A, Bello IO (2023) Chapter 18\u2014Therapeutic potentials of medicinal plants and significance of computational tools in anti-cancer drug discovery. In Egbuna C, Rudrapal M, Tijjani H (Eds.), Phytochemistry, computational tools and databases in drug discovery (pp. 393\u2013455). Elsevier. https:\/\/doi.org\/10.1016\/B978-0-323-90593-0.00017-4","DOI":"10.1016\/B978-0-323-90593-0.00017-4"},{"key":"2065_CR4","doi-asserted-by":"publisher","first-page":"111389","DOI":"10.1016\/j.colsurfb.2020.111389","volume":"197","author":"R Ahmad","year":"2021","unstructured":"Ahmad R, Srivastava S, Ghosh S, Khare SK (2021) Phytochemical delivery through nanocarriers: a review. Colloids Surf B Biointerfaces 197:111389","journal-title":"Colloids Surf B Biointerfaces"},{"key":"2065_CR5","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/ar2982","volume":"12","author":"S Ahmed","year":"2010","unstructured":"Ahmed S (2010) Green tea polyphenol epigallocatechin 3-gallate in arthritis: progress and promise. Arthritis Res Ther 12:1\u20139","journal-title":"Arthritis Res Ther"},{"issue":"13","key":"2065_CR6","doi-asserted-by":"publisher","first-page":"1360","DOI":"10.1001\/jama.2018.13103","volume":"320","author":"D Aletaha","year":"2018","unstructured":"Aletaha D, Smolen JS (2018) Diagnosis and management of rheumatoid arthritis: a review. JAMA 320(13):1360\u20131372","journal-title":"JAMA"},{"issue":"3","key":"2065_CR7","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1016\/j.reumae.2017.07.011","volume":"15","author":"R Alfaro-Lara","year":"2019","unstructured":"Alfaro-Lara R, Espinosa-Ortega HF, Arce-Salinas CA (2019) Systematic review and meta-analysis of the efficacy and safety of leflunomide and methotrexate in the treatment of rheumatoid arthritis. Reumatol Cl\u00edn (English Edition) 15(3):133\u2013139. https:\/\/doi.org\/10.1016\/j.reumae.2017.07.011","journal-title":"Reumatol Cl\u00edn (English Edition)"},{"issue":"4","key":"2065_CR8","doi-asserted-by":"publisher","first-page":"547","DOI":"10.3923\/ijp.2024.547.551","volume":"20","author":"A Alharthi","year":"2024","unstructured":"Alharthi A, Magadmi R, Jamal M (2024) Polymorphisms for the clinical efficacy and toxicity of methotrexate in patients with rheumatoid arthritis: systemic review. IJP 20(4):547\u2013551. https:\/\/doi.org\/10.3923\/ijp.2024.547.551","journal-title":"IJP"},{"key":"2065_CR9","doi-asserted-by":"publisher","first-page":"134903","DOI":"10.1016\/j.ijbiomac.2024.134903","volume":"278","author":"A Ali","year":"2024","unstructured":"Ali A, Rahul Jori C, Kumar J, Kumar A, Kanika, et al (2024) Sinapic acid-pullulan based inflammation responsive nanomicelles for the local treatment of experimental inflammatory arthritis. Int J Biol Macromol 278:134903. https:\/\/doi.org\/10.1016\/j.ijbiomac.2024.134903","journal-title":"Int J Biol Macromol"},{"issue":"2","key":"2065_CR10","doi-asserted-by":"publisher","first-page":"657","DOI":"10.1039\/C8BM01224E","volume":"7","author":"SD Allen","year":"2019","unstructured":"Allen SD, Liu Y-G, Kim T, Bobbala S, Yi S, Zhang X et al (2019) Celastrol-loaded PEG-b-PPS nanocarriers as an anti-inflammatory treatment for atherosclerosis. Biomater Sci 7(2):657\u2013668","journal-title":"Biomater Sci"},{"issue":"9","key":"2065_CR11","doi-asserted-by":"publisher","first-page":"1013","DOI":"10.1111\/1756-185x.14373","volume":"25","author":"W Alturaiki","year":"2022","unstructured":"Alturaiki W, Alhamad A, Alturaiqy M, Mir SA, Iqbal D, Bin Dukhyil AA et al (2022) Assessment of IL-1\u03b2, IL-6, TNF-\u03b1, IL-8, and CCL 5 levels in newly diagnosed Saudi patients with rheumatoid arthritis. Int J Rheum Dis 25(9):1013\u20131019. https:\/\/doi.org\/10.1111\/1756-185x.14373","journal-title":"Int J Rheum Dis"},{"key":"2065_CR12","doi-asserted-by":"publisher","first-page":"118911","DOI":"10.1016\/j.lfs.2020.118911","volume":"266","author":"P Anchi","year":"2021","unstructured":"Anchi P, Swamy V, Godugu C (2021) Nimbolide exerts protective effects in complete Freund\u2019s adjuvant induced inflammatory arthritis via abrogation of STAT-3\/NF-\u03baB\/Notch-1 signaling. Life Sci 266:118911. https:\/\/doi.org\/10.1016\/j.lfs.2020.118911","journal-title":"Life Sci"},{"issue":"1","key":"2065_CR13","first-page":"6290682","volume":"2016","author":"Y Araki","year":"2016","unstructured":"Araki Y, Mimura T (2016) The mechanisms underlying chronic inflammation in rheumatoid arthritis from the perspective of the epigenetic landscape. J Immunol Res 2016(1):6290682","journal-title":"J Immunol Res"},{"issue":"7","key":"2065_CR15","doi-asserted-by":"publisher","first-page":"940","DOI":"10.1002\/ejp.620","volume":"19","author":"R Arora","year":"2015","unstructured":"Arora R, Kuhad A, Kaur IP, Chopra K (2015) Curcumin loaded solid lipid nanoparticles ameliorate adjuvant-induced arthritis in rats. Eur J Pain 19(7):940\u2013952. https:\/\/doi.org\/10.1002\/ejp.620","journal-title":"Eur J Pain"},{"issue":"7","key":"2065_CR16","doi-asserted-by":"publisher","first-page":"1729","DOI":"10.1007\/s00246-013-0693-5","volume":"34","author":"S Asgary","year":"2013","unstructured":"Asgary S, Kelishadi R, Rafieian-Kopaei M, Najafi S, Najafi M, Sahebkar A (2013) Investigation of the lipid-modifying and antiinflammatory effects of cornus mas L. supplementation on dyslipidemic children and adolescents (article). Pediatr Cardiol 34(7):1729\u20131735. https:\/\/doi.org\/10.1007\/s00246-013-0693-5","journal-title":"Pediatr Cardiol"},{"issue":"9","key":"2065_CR17","doi-asserted-by":"publisher","first-page":"3057","DOI":"10.1021\/acs.molpharmaceut.2c00455","volume":"19","author":"M Bagheri","year":"2022","unstructured":"Bagheri M, van Nostrum CF, Kok RJ, Storm G, Hennink WE, Heger M (2022) Utility of intravenous curcumin nanodelivery systems for improving in vivo pharmacokinetics and anticancer pharmacodynamics. Mol Pharm 19(9):3057\u20133074","journal-title":"Mol Pharm"},{"key":"2065_CR18","doi-asserted-by":"publisher","first-page":"666","DOI":"10.1016\/j.biopha.2017.06.052","volume":"93","author":"S Bahri","year":"2017","unstructured":"Bahri S, Ali RB, Abidi A, Jameleddine S (2017) The efficacy of plant extract and bioactive compounds approaches in the treatment of pulmonary fibrosis: a systematic review. Biomed Pharmacother 93:666\u2013673","journal-title":"Biomed Pharmacother"},{"key":"2065_CR19","doi-asserted-by":"crossref","unstructured":"Baizabal-Aguirre VM (2017) 'Cross-talk mechanisms of Wnt\/beta-catenin signaling components with TLR-activated signaling molecules in the inflammatory response\u2019. Frontiers Media SA, p. 1396","DOI":"10.3389\/fimmu.2017.01396"},{"key":"2065_CR20","doi-asserted-by":"publisher","first-page":"155945","DOI":"10.1016\/j.prp.2025.155945","volume":"269","author":"MZA Begh","year":"2025","unstructured":"Begh MZA, Zehravi M, Reza F, Sweilam SH, Shanmugarajan TS, Arjun UVNV et al (2025) Therapeutic potential of phytocompounds in rheumatoid arthritis: molecular insights and clinical applications. Pathol Res Pract 269:155945. https:\/\/doi.org\/10.1016\/j.prp.2025.155945","journal-title":"Pathol Res Pract"},{"issue":"11","key":"2065_CR21","doi-asserted-by":"publisher","first-page":"846","DOI":"10.1016\/j.tem.2021.07.011","volume":"32","author":"D Bellavia","year":"2021","unstructured":"Bellavia D, Caradonna F, Dimarco E, Costa V, Carina V, De Luca A et al (2021) Terpenoid treatment in osteoporosis: this is where we have come in research. Trends Endocrinol Metab 32(11):846\u2013861","journal-title":"Trends Endocrinol Metab"},{"key":"2065_CR22","doi-asserted-by":"publisher","unstructured":"Bel\u0161\u010dak-Cvitanovi\u0107 A, Durgo K, Hu\u0111ek A, Ba\u010dun-Dru\u017eina V, Komes D (2018) 1\u2014Overview of polyphenols and their properties. In Galanakis CM (Ed.), Polyphenols: properties, recovery, and applications (pp. 3\u201344). Woodhead Publishing. https:\/\/doi.org\/10.1016\/B978-0-12-813572-3.00001-4","DOI":"10.1016\/B978-0-12-813572-3.00001-4"},{"issue":"1","key":"2065_CR23","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1038\/s41698-017-0038-6","volume":"1","author":"AY Berman","year":"2017","unstructured":"Berman AY, Motechin RA, Wiesenfeld MY, Holz MK (2017) The therapeutic potential of resveratrol: a review of clinical trials. NPJ Precis Oncol 1(1):35. https:\/\/doi.org\/10.1038\/s41698-017-0038-6","journal-title":"NPJ Precis Oncol"},{"issue":"11","key":"2065_CR24","doi-asserted-by":"publisher","first-page":"362","DOI":"10.1007\/s13205-023-03787-6","volume":"13","author":"A Bhoi","year":"2023","unstructured":"Bhoi A, Dwivedi SD, Singh D, Keshavkant S, Singh MR (2023) Mechanistic prospective and pharmacological attributes of quercetin in attenuation of different types of arthritis. 3 Biotech 13(11):362. https:\/\/doi.org\/10.1007\/s13205-023-03787-6","journal-title":"3 Biotech"},{"key":"2065_CR25","doi-asserted-by":"publisher","first-page":"134146","DOI":"10.1016\/j.cej.2021.134146","volume":"432","author":"A Bigham","year":"2022","unstructured":"Bigham A, Rahimkhoei V, Abasian P, Delfi M, Naderi J, Ghomi M et al (2022) Advances in tannic acid-incorporated biomaterials: infection treatment, regenerative medicine, cancer therapy, and biosensing. Chem Eng J 432:134146. https:\/\/doi.org\/10.1016\/j.cej.2021.134146","journal-title":"Chem Eng J"},{"key":"2065_CR26","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1016\/j.jnutbio.2017.10.010","volume":"53","author":"SM Borghi","year":"2018","unstructured":"Borghi SM, Mizokami SS, Pinho-Ribeiro FA, Fattori V, Crespigio J, Clemente-Napimoga JT et al (2018) The flavonoid quercetin inhibits titanium dioxide (TiO2)-induced chronic arthritis in mice. J Nutr Biochem 53:81\u201395. https:\/\/doi.org\/10.1016\/j.jnutbio.2017.10.010","journal-title":"J Nutr Biochem"},{"issue":"11","key":"2065_CR27","doi-asserted-by":"publisher","first-page":"3537","DOI":"10.1172\/JCI36389","volume":"118","author":"FM Brennan","year":"2008","unstructured":"Brennan FM, McInnes IB (2008) Evidence that cytokines play a role in rheumatoid arthritis. J Clin Invest 118(11):3537\u20133545","journal-title":"J Clin Invest"},{"issue":"9","key":"2065_CR28","doi-asserted-by":"publisher","first-page":"1671","DOI":"10.3390\/nano10091671","volume":"10","author":"K Bromma","year":"2020","unstructured":"Bromma K, Chithrani DB (2020) Advances in gold nanoparticle-based combined cancer therapy. Nanomaterials 10(9):1671","journal-title":"Nanomaterials"},{"issue":"8","key":"2065_CR29","doi-asserted-by":"publisher","first-page":"7586","DOI":"10.3390\/ijms24087586","volume":"24","author":"T Budlewski","year":"2023","unstructured":"Budlewski T, Sarnik J, Galita G, Dragan G, Brzezi\u0144ska O, Pop\u0142awska M et al (2023) SNP in PTPN22, PADI4, and STAT4 but not TRAF1 and CD40 increase the risk of rheumatoid arthritis in Polish population. Int J Mol Sci 24(8):7586","journal-title":"Int J Mol Sci"},{"issue":"9","key":"2065_CR30","doi-asserted-by":"publisher","first-page":"1445","DOI":"10.1136\/annrheumdis-2012-202450","volume":"72","author":"GR Burmester","year":"2013","unstructured":"Burmester GR, Weinblatt ME, McInnes IB, Porter D, Barbarash O, Vatutin M et al (2013) Efficacy and safety of mavrilimumab in subjects with rheumatoid arthritis. Ann Rheum Dis 72(9):1445\u20131452","journal-title":"Ann Rheum Dis"},{"issue":"6","key":"2065_CR31","doi-asserted-by":"publisher","first-page":"364","DOI":"10.1038\/s41584-019-0219-5","volume":"15","author":"R Busch","year":"2019","unstructured":"Busch R, Kollnberger S, Mellins ED (2019) HLA associations in inflammatory arthritis: emerging mechanisms and clinical implications. Nat Rev Rheumatol 15(6):364\u2013381","journal-title":"Nat Rev Rheumatol"},{"issue":"1-2","key":"2065_CR32","first-page":"199","volume":"551","author":"H Carlsen","year":"2004","unstructured":"Carlsen H, Alexander G, Austenaa LM, Ebihara K, Blomhoff R (2004) Molecular imaging of the transcription factor NF-\u03baB, a primary regulator of stress response. Mutat Res-Fund Mol Mech Mutagen 551(1\u20132):199\u2013211","journal-title":"Mutat Res-Fund Mol Mech Mutagen"},{"key":"2065_CR33","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1016\/j.phymed.2018.10.028","volume":"57","author":"AMS Carvalho","year":"2019","unstructured":"Carvalho AMS, Heimfarth L, Santos KA, Guimar\u00e3es AG, Picot L, Almeida JRGS et al (2019) Terpenes as possible drugs for the mitigation of arthritic symptoms\u2014a systematic review. Phytomedicine 57:137\u2013147. https:\/\/doi.org\/10.1016\/j.phymed.2018.10.028","journal-title":"Phytomedicine"},{"key":"2065_CR34","doi-asserted-by":"publisher","unstructured":"Casas-Grajales S, Muriel P (2017) Chapter 43\u2014the liver, oxidative stress, and antioxidants. In Muriel P (Ed.), Liver Pathophysiology (pp. 583\u2013604). Boston: Academic Press. https:\/\/doi.org\/10.1016\/B978-0-12-804274-8.00043-6","DOI":"10.1016\/B978-0-12-804274-8.00043-6"},{"issue":"4","key":"2065_CR35","doi-asserted-by":"publisher","first-page":"451","DOI":"10.1016\/j.jtcme.2017.08.006","volume":"8","author":"A Chandrasekara","year":"2018","unstructured":"Chandrasekara A, Shahidi F (2018) Herbal beverages: bioactive compounds and their role in disease risk reduction\u2014a review. J Tradit Complement Med 8(4):451\u2013458. https:\/\/doi.org\/10.1016\/j.jtcme.2017.08.006","journal-title":"J Tradit Complement Med"},{"issue":"7","key":"2065_CR36","doi-asserted-by":"publisher","first-page":"692","DOI":"10.1016\/j.acthis.2013.02.005","volume":"115","author":"L Chen","year":"2013","unstructured":"Chen L, Lu Y, Chu Y, Xie J, Ding Wg, Wang F (2013) Tissue factor expression in rheumatoid synovium: a potential role in pannus invasion of rheumatoid arthritis. Acta Histochem 115(7):692\u2013697","journal-title":"Acta Histochem"},{"key":"2065_CR37","doi-asserted-by":"publisher","first-page":"1181159","DOI":"10.3389\/fchem.2023.1181159","volume":"11","author":"Q Chen","year":"2023","unstructured":"Chen Q, Wu C, Wang S, Wang Q, Wu P, Wang L et al (2023) Glycyrrhizic acid modified Poria cocos polyscaccharide carbon dots dissolving microneedles for methotrexate delivery to treat rheumatoid arthritis. Front Chem 11:1181159","journal-title":"Front Chem"},{"issue":"38","key":"2065_CR38","doi-asserted-by":"publisher","first-page":"e22241","DOI":"10.1097\/MD.0000000000022241","volume":"99","author":"T Chen","year":"2020","unstructured":"Chen T, Zhang X, Zhu G, Liu H, Chen J, Wang Y et al (2020) Quercetin inhibits TNF-\u03b1 induced HUVECs apoptosis and inflammation via downregulating NF-kB and AP-1 signaling pathway in vitro. Medicine 99(38):e22241","journal-title":"Medicine"},{"issue":"39","key":"2065_CR39","doi-asserted-by":"publisher","first-page":"18209","DOI":"10.1039\/C9NR05922A","volume":"11","author":"X Chen","year":"2019","unstructured":"Chen X, Zhu X, Ma L, Lin A, Gong Y, Yuan G et al (2019a) A core\u2013shell structure QRu-PLGA-RES-DS NP nanocomposite with photothermal response-induced M2 macrophage polarization for rheumatoid arthritis therapy. Nanoscale 11(39):18209\u201318223","journal-title":"Nanoscale"},{"key":"2065_CR40","doi-asserted-by":"publisher","first-page":"1615519","DOI":"10.3389\/fphar.2025.1615519","volume":"16","author":"Y Chen","year":"2025","unstructured":"Chen Y, Deng Y, Zheng H, Li B, Yang Y, Huang J et al (2025) Xuetongsu attenuates synovial inflammation in rheumatoid arthritis by inhibiting the IL-23\/IL-17\/NF-\u03baB inflammatory axis. Front Pharmacol 16:1615519. https:\/\/doi.org\/10.3389\/fphar.2025.1615519","journal-title":"Front Pharmacol"},{"issue":"1","key":"2065_CR41","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1038\/s41584-018-0109-2","volume":"15","author":"Z Chen","year":"2019","unstructured":"Chen Z, Bozec A, Ramming A, Schett G (2019b) Anti-inflammatory and immune-regulatory cytokines in rheumatoid arthritis. Nat Rev Rheumatol 15(1):9\u201317","journal-title":"Nat Rev Rheumatol"},{"key":"2065_CR42","doi-asserted-by":"publisher","DOI":"10.2174\/0109298673309489240816063313","author":"Y Cheng","year":"2024","unstructured":"Cheng Y, Wang L, Zhang S, Jian W, Zeng B, Liang L et al (2024) The investigation of Nfkappab inhibitors to block cell proliferation in OSCC cells lines. Curr Med Chem. https:\/\/doi.org\/10.2174\/0109298673309489240816063313","journal-title":"Curr Med Chem"},{"issue":"3","key":"2065_CR43","first-page":"907","volume":"31","author":"SS Chiu","year":"2011","unstructured":"Chiu SS, Lui E, Majeed M, Vishwanatha JK, Ranjan AP, Maitra A et al (2011) Differential distribution of intravenous curcumin formulations in the rat brain. Anticancer Res 31(3):907\u2013911","journal-title":"Anticancer Res"},{"key":"2065_CR44","doi-asserted-by":"publisher","unstructured":"Cicero AFG, Baggioni A (2016) Berberine and its role in chronic disease. In Gupta SC, Prasad S, Aggarwal BB (Eds.), Anti-inflammatory nutraceuticals and chronic diseases (pp. 27\u201345). Cham: Springer International Publishing. https:\/\/doi.org\/10.1007\/978-3-319-41334-1_2","DOI":"10.1007\/978-3-319-41334-1_2"},{"issue":"3","key":"2065_CR45","doi-asserted-by":"publisher","first-page":"246","DOI":"10.1016\/j.jobab.2024.05.001","volume":"9","author":"R Ciriminna","year":"2024","unstructured":"Ciriminna R, Meneguzzo F, Petri GL, Meneguzzo C, Angellotti G, Pagliaro M (2024) Chestnut tannin: new use, research and bioeconomy. J Bioresour Bioprod 9(3):246\u2013252. https:\/\/doi.org\/10.1016\/j.jobab.2024.05.001","journal-title":"J Bioresour Bioprod"},{"key":"2065_CR46","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1016\/j.ejps.2015.07.012","volume":"78","author":"K Coradini","year":"2015","unstructured":"Coradini K, Friedrich RB, Fonseca FN, Vencato MS, Andrade DF, Oliveira CM et al (2015) A novel approach to arthritis treatment based on resveratrol and curcumin co-encapsulated in lipid-core nanocapsules: in vivo studies. Eur J Pharm Sci 78:163\u2013170. https:\/\/doi.org\/10.1016\/j.ejps.2015.07.012","journal-title":"Eur J Pharm Sci"},{"issue":"12","key":"2065_CR47","doi-asserted-by":"publisher","first-page":"1263","DOI":"10.3390\/antiox9121263","volume":"9","author":"P Cosme","year":"2020","unstructured":"Cosme P, Rodr\u00edguez AB, Espino J, Garrido M (2020) Plant phenolics: bioavailability as a key determinant of their potential health-promoting applications. Antioxidants 9(12):1263","journal-title":"Antioxidants"},{"key":"2065_CR48","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s10876-020-01973-7","volume":"33","author":"Q Cui","year":"2022","unstructured":"Cui Q, Wang Y (2022) Sinapic acid loaded secondary growth of SiO2\u2013Au core shell nanostructure as an effective antiarthritic agent to treat collagen-induced arthritis. J Cluster Sci 33:1\u20138","journal-title":"J Cluster Sci"},{"issue":"1","key":"2065_CR49","doi-asserted-by":"publisher","first-page":"3391","DOI":"10.1080\/21691401.2019.1649269","volume":"47","author":"X Cui","year":"2019","unstructured":"Cui X, Wang R, Bian P, Wu Q, Seshadri VDD, Liu L (2019) Evaluation of antiarthritic activity of nimbolide against Freund\u2019s adjuvant induced arthritis in rats. Artif Cells Nanomed Biotechnol 47(1):3391\u20133398","journal-title":"Artif Cells Nanomed Biotechnol"},{"issue":"3","key":"2065_CR50","doi-asserted-by":"publisher","first-page":"109869","DOI":"10.1016\/j.cclet.2024.109869","volume":"36","author":"C Dai","year":"2025","unstructured":"Dai C, Wang L, You X, Zhao Y, Cao Z, Wu J (2025) Coffee-derived self-anti-inflammatory polymer as drug nanocarrier for enhanced rheumatoid arthritis treatment. Chin Chem Lett 36(3):109869. https:\/\/doi.org\/10.1016\/j.cclet.2024.109869","journal-title":"Chin Chem Lett"},{"issue":"4","key":"2065_CR51","doi-asserted-by":"publisher","first-page":"163","DOI":"10.5152\/eurjrheum.2023.23064","volume":"10","author":"JF de Carvalho","year":"2023","unstructured":"de Carvalho JF, Lerner A (2023) Resveratrol in rheumatological diseases: a systematic review. Eur J Rheumatol 10(4):163","journal-title":"Eur J Rheumatol"},{"issue":"10","key":"2065_CR52","doi-asserted-by":"publisher","first-page":"2661","DOI":"10.1093\/rheumatology\/keaa232","volume":"59","author":"LE Dedmon","year":"2020","unstructured":"Dedmon LE (2020) The genetics of rheumatoid arthritis. Rheumatology 59(10):2661\u20132670","journal-title":"Rheumatology"},{"issue":"11","key":"2065_CR53","doi-asserted-by":"publisher","first-page":"3621","DOI":"10.3390\/molecules27113621","volume":"27","author":"OV Demets","year":"2022","unstructured":"Demets OV, Takibayeva AT, Kassenov RZ, Aliyeva MR (2022) Methods of betulin extraction from birch bark. Molecules 27(11):3621","journal-title":"Molecules"},{"issue":"1","key":"2065_CR54","doi-asserted-by":"publisher","first-page":"124","DOI":"10.1111\/imr.12842","volume":"294","author":"MK Demoruelle","year":"2020","unstructured":"Demoruelle MK, Wilson TM, Deane KD (2020) Lung inflammation in the pathogenesis of rheumatoid arthritis. Immunol Rev 294(1):124\u2013132","journal-title":"Immunol Rev"},{"issue":"3","key":"2065_CR55","doi-asserted-by":"publisher","first-page":"101037","DOI":"10.1016\/j.ajps.2025.101037","volume":"20","author":"Y Deng","year":"2025","unstructured":"Deng Y, Li B, Zheng H, Liang L, Yang Y, Liu S et al (2025) Multifunctional Prussian blue nanoparticles loading with Xuetongsu for efficient rheumatoid arthritis therapy through targeting inflammatory macrophages and osteoclasts. Asian J Pharm Sci 20(3):101037. https:\/\/doi.org\/10.1016\/j.ajps.2025.101037","journal-title":"Asian J Pharm Sci"},{"issue":"1","key":"2065_CR56","first-page":"170","volume":"138","author":"S Deodhar","year":"2013","unstructured":"Deodhar S, Sethi R, Srimal R (2013) Preliminary study on antirheumatic activity of curcumin (diferuloyl methane). Indian J Med Res 138(1):170\u2013170","journal-title":"Indian J Med Res"},{"key":"2065_CR57","doi-asserted-by":"publisher","DOI":"10.1007\/s10787-025-01722-0","author":"S Dhankhar","year":"2025","unstructured":"Dhankhar S, Kumar J, Chauhan S, Zahoor I, Wani SN, Saini M et al (2025) Flavonoids and flavonoid-based nanoparticles for the treatment of arthritis. Inflammopharmacology. https:\/\/doi.org\/10.1007\/s10787-025-01722-0","journal-title":"Inflammopharmacology"},{"issue":"1","key":"2065_CR58","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1007\/s13346-024-01581-2","volume":"15","author":"N Diao","year":"2025","unstructured":"Diao N, Liu Y, Wang W, Cao M, Liu X, Yang W et al (2025) Resveratrol nanocrystals based dissolving microneedles with highly efficient for rheumatoid arthritis. Drug Deliv Transl Res 15(1):203\u2013215. https:\/\/doi.org\/10.1007\/s13346-024-01581-2","journal-title":"Drug Deliv Transl Res"},{"issue":"2","key":"2065_CR59","doi-asserted-by":"publisher","first-page":"174","DOI":"10.1016\/j.nut.2015.08.017","volume":"32","author":"GT Diaz-Gerevini","year":"2016","unstructured":"Diaz-Gerevini GT, Repossi G, Dain A, Tarres MC, Das UN, Eynard AR (2016) Beneficial action of resveratrol: how and why? Nutrition 32(2):174\u2013178","journal-title":"Nutrition"},{"issue":"2","key":"2065_CR60","doi-asserted-by":"publisher","first-page":"330","DOI":"10.1016\/j.lwt.2014.12.020","volume":"61","author":"V Dinesh Kumar","year":"2015","unstructured":"Dinesh Kumar V, Verma PRP, Singh SK (2015) Development and evaluation of biodegradable polymeric nanoparticles for the effective delivery of quercetin using a quality by design approach. LWT Food Sci Technol 61(2):330\u2013338. https:\/\/doi.org\/10.1016\/j.lwt.2014.12.020","journal-title":"LWT Food Sci Technol"},{"key":"2065_CR61","doi-asserted-by":"publisher","first-page":"284","DOI":"10.1016\/j.lfs.2018.06.013","volume":"207","author":"HM Doss","year":"2018","unstructured":"Doss HM, Samarpita S, Ganesan R, Rasool M (2018) Ferulic acid, a dietary polyphenol suppresses osteoclast differentiation and bone erosion via the inhibition of RANKL dependent NF-\u03baB signalling pathway. Life Sci 207:284\u2013295. https:\/\/doi.org\/10.1016\/j.lfs.2018.06.013","journal-title":"Life Sci"},{"key":"2065_CR62","doi-asserted-by":"publisher","unstructured":"Drijfhout FP, David Morgan E (2010) 4.11\u2014Terrestrial natural products as antifeedants. In Liu H-W, Mander L (Eds.), Comprehensive Natural Products II (pp. 457\u2013501). Oxford: Elsevier. https:\/\/doi.org\/10.1016\/B978-008045382-8.00103-9","DOI":"10.1016\/B978-008045382-8.00103-9"},{"issue":"8","key":"2065_CR63","doi-asserted-by":"publisher","first-page":"2293","DOI":"10.3390\/ijms19082293","volume":"19","author":"S Dudics","year":"2018","unstructured":"Dudics S, Venkatesha SH, Moudgil KD (2018) The micro-RNA expression profiles of autoimmune arthritis reveal novel biomarkers of the disease and therapeutic response. Int J Mol Sci 19(8):2293","journal-title":"Int J Mol Sci"},{"issue":"1","key":"2065_CR64","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1186\/s13075-019-1880-4","volume":"21","author":"K Ebina","year":"2019","unstructured":"Ebina K, Hashimoto M, Yamamoto W, Hirano T, Hara R, Katayama M et al (2019) Drug tolerability and reasons for discontinuation of seven biologics in 4466 treatment courses of rheumatoid arthritis\u2014the ANSWER cohort study. Arthritis Res Ther 21(1):91. https:\/\/doi.org\/10.1186\/s13075-019-1880-4","journal-title":"Arthritis Res Ther"},{"issue":"8","key":"2065_CR65","doi-asserted-by":"publisher","first-page":"3733","DOI":"10.1007\/s12010-022-03812-z","volume":"194","author":"M Ebrahimian","year":"2022","unstructured":"Ebrahimian M, Mahvelati F, Malaekeh-Nikouei B, Hashemi E, Oroojalian F, Hashemi M (2022) Bromelain loaded lipid-polymer hybrid nanoparticles for oral delivery: formulation and characterization. Appl Biochem Biotechnol 194(8):3733\u20133748","journal-title":"Appl Biochem Biotechnol"},{"key":"2065_CR66","doi-asserted-by":"publisher","first-page":"123150","DOI":"10.1016\/j.ijpharm.2023.123150","volume":"642","author":"EN Essien","year":"2023","unstructured":"Essien EN, Revi N, Khatri V, Liu S, Van Thiel G, Bijukumar D (2023) Methotrexate and sulforaphane loaded PBA-G5-PAMAM dendrimers as a combination therapy for anti-inflammatory response in an intra-articular joint arthritic animal model. Int J Pharm 642:123150. https:\/\/doi.org\/10.1016\/j.ijpharm.2023.123150","journal-title":"Int J Pharm"},{"issue":"6","key":"2065_CR67","doi-asserted-by":"publisher","first-page":"2360","DOI":"10.1016\/j.bmc.2009.02.014","volume":"17","author":"G-J Fan","year":"2009","unstructured":"Fan G-J, Liu X-D, Qian Y-P, Shang Y-J, Li X-Z, Dai F et al (2009) 4, 4\u2032-dihydroxy-trans-stilbene, a resveratrol analogue, exhibited enhanced antioxidant activity and cytotoxicity. Bioorg Med Chem 17(6):2360\u20132365","journal-title":"Bioorg Med Chem"},{"issue":"1","key":"2065_CR68","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1007\/s40820-020-0410-x","volume":"12","author":"X-x Fan","year":"2020","unstructured":"Fan X-x, Xu M-z, Leung EL-H, Jun C, Yuan Z, Liu L (2020) ROS-responsive berberine polymeric micelles effectively suppressed the inflammation of rheumatoid arthritis by targeting mitochondria. Nano-Micro Lett 12(1):76. https:\/\/doi.org\/10.1007\/s40820-020-0410-x","journal-title":"Nano-Micro Lett"},{"issue":"28","key":"2065_CR69","doi-asserted-by":"publisher","first-page":"23595","DOI":"10.1021\/acsami.8b06236","volume":"10","author":"Z Fan","year":"2018","unstructured":"Fan Z, Li J, Liu J, Jiao H, Liu B (2018) Anti-inflammation and joint lubrication dual effects of a novel hyaluronic acid\/curcumin nanomicelle improve the efficacy of rheumatoid arthritis therapy. ACS Appl Mater Interfaces 10(28):23595\u201323604","journal-title":"ACS Appl Mater Interfaces"},{"issue":"7","key":"2065_CR70","doi-asserted-by":"publisher","first-page":"1514","DOI":"10.3390\/life13071514","volume":"13","author":"C Faustino","year":"2023","unstructured":"Faustino C, Pinheiro L, Duarte N (2023) Triterpenes as potential drug candidates for rheumatoid arthritis treatment. Life 13(7):1514","journal-title":"Life"},{"issue":"7","key":"2065_CR71","doi-asserted-by":"publisher","first-page":"755","DOI":"10.2174\/138920006778520552","volume":"7","author":"WY Feng","year":"2006","unstructured":"Feng WY (2006) Metabolism of green tea catechins: an overview. Curr Drug Metab 7(7):755\u2013809","journal-title":"Curr Drug Metab"},{"issue":"5","key":"2065_CR72","doi-asserted-by":"publisher","first-page":"5537","DOI":"10.1002\/jcp.27362","volume":"234","author":"N Fereydouni","year":"2019","unstructured":"Fereydouni N, Darroudi M, Movaffagh J, Shahroodi A, Butler AE, Ganjali S et al (2019) Curcumin nanofibers for the purpose of wound healing (Review). J Cell Physiol 234(5):5537\u20135554. https:\/\/doi.org\/10.1002\/jcp.27362","journal-title":"J Cell Physiol"},{"issue":"29","key":"2065_CR73","doi-asserted-by":"publisher","first-page":"7153","DOI":"10.1039\/d4tb00697f","volume":"12","author":"D Fern\u00e1ndez-Villa","year":"2024","unstructured":"Fern\u00e1ndez-Villa D, Aguilar MR, Rojo L (2024) Europium-tannic acid nanocomplexes devised for bone regeneration under oxidative or inflammatory environments. J Mater Chem B 12(29):7153\u20137170. https:\/\/doi.org\/10.1039\/d4tb00697f","journal-title":"J Mater Chem B"},{"issue":"10","key":"2065_CR74","first-page":"591","volume":"18","author":"A Finckh","year":"2022","unstructured":"Finckh A, Gilbert B, Hodkinson B, Bae S-C, Thomas R, Deane KD et al (2022) Global epidemiology of rheumatoid arthritis. Nat Rev Rheumatol 18(10):591\u2013602","journal-title":"Nat Rev Rheumatol"},{"issue":"4","key":"2065_CR75","doi-asserted-by":"publisher","first-page":"813","DOI":"10.1016\/j.freeradbiomed.2011.06.002","volume":"51","author":"CG Fraga","year":"2011","unstructured":"Fraga CG, Oteiza PI (2011) Dietary flavonoids: role of (\u2212)-epicatechin and related procyanidins in cell signaling. Free Radic Biol Med 51(4):813\u2013823. https:\/\/doi.org\/10.1016\/j.freeradbiomed.2011.06.002","journal-title":"Free Radic Biol Med"},{"key":"2065_CR76","doi-asserted-by":"publisher","first-page":"111888","DOI":"10.1016\/j.biopha.2021.111888","volume":"141","author":"Y-S Fu","year":"2021","unstructured":"Fu Y-S, Chen T-H, Weng L, Huang L, Lai D, Weng C-F (2021) Pharmacological properties and underlying mechanisms of curcumin and prospects in medicinal potential. Biomed Pharmacother 141:111888. https:\/\/doi.org\/10.1016\/j.biopha.2021.111888","journal-title":"Biomed Pharmacother"},{"issue":"2","key":"2065_CR77","doi-asserted-by":"publisher","first-page":"303","DOI":"10.1080\/08982104.2023.2273390","volume":"34","author":"HA Gad","year":"2024","unstructured":"Gad HA, Abbas H, El Sayed NS, Khattab MA, El Hassab MA, Mansour M (2024) Berberine loaded thermosensitive lipid nanoparticles: in vitro characterization, in silico study, and in vivo anti-arthritic effect. J Liposome Res 34(2):303\u2013315","journal-title":"J Liposome Res"},{"key":"2065_CR78","doi-asserted-by":"publisher","first-page":"208","DOI":"10.1016\/j.phrs.2017.02.008","volume":"119","author":"S Ganjali","year":"2017","unstructured":"Ganjali S, Blesso CN, Banach M, Pirro M, Majeed M, Sahebkar A (2017) Effects of curcumin on HDL functionality (review). Pharmacol Res 119:208\u2013218. https:\/\/doi.org\/10.1016\/j.phrs.2017.02.008","journal-title":"Pharmacol Res"},{"issue":"33","key":"2065_CR79","doi-asserted-by":"publisher","first-page":"6915","DOI":"10.2174\/0929867328666210525124707","volume":"28","author":"A Ganji","year":"2021","unstructured":"Ganji A, Farahani I, Saeedifar AM, Mosayebi G, Ghazavi A, Majeed M et al (2021) Protective effects of curcumin against lipopolysaccharide-induced toxicity (article). Curr Med Chem 28(33):6915\u20136930. https:\/\/doi.org\/10.2174\/0929867328666210525124707","journal-title":"Curr Med Chem"},{"issue":"4","key":"2065_CR80","doi-asserted-by":"publisher","first-page":"940","DOI":"10.3945\/ajcn.2009.28584","volume":"91","author":"H Ghanim","year":"2010","unstructured":"Ghanim H, Sia CL, Upadhyay M, Korzeniewski K, Viswanathan P, Abuaysheh S et al (2010) &lt;article-title update=\u201cadded\u201d&gt;Orange juice neutralizes the proinflammatory effect of a high-fat, high-carbohydrate meal and prevents endotoxin increase and Toll-like receptor expression. Am J Clin Nutr 91(4):940\u2013949. https:\/\/doi.org\/10.3945\/ajcn.2009.28584","journal-title":"Am J Clin Nutr"},{"key":"2065_CR81","doi-asserted-by":"publisher","first-page":"104742","DOI":"10.1016\/j.jddst.2023.104742","volume":"87","author":"S Gharat","year":"2023","unstructured":"Gharat S, Pandya A, Kulkarni D, Momin M (2023) Unravelling the potential of nanocarriers to deliver curcumin for the management of rheumatoid arthritis. J Drug Deliv Sci Technol 87:104742. https:\/\/doi.org\/10.1016\/j.jddst.2023.104742","journal-title":"J Drug Deliv Sci Technol"},{"issue":"10","key":"2065_CR82","doi-asserted-by":"publisher","first-page":"2376","DOI":"10.3390\/nu11102376","volume":"11","author":"A Giordano","year":"2019","unstructured":"Giordano A, Tommonaro G (2019) Curcumin and cancer. Nutrients 11(10):2376","journal-title":"Nutrients"},{"key":"2065_CR83","doi-asserted-by":"publisher","first-page":"108622","DOI":"10.1016\/j.biopha.2019.108622","volume":"112","author":"JP Gokhale","year":"2019","unstructured":"Gokhale JP, Mahajan HS, Surana SJ (2019) Quercetin loaded nanoemulsion-based gel for rheumatoid arthritis: in vivo and in vitro studies. Biomed Pharmacother 112:108622","journal-title":"Biomed Pharmacother"},{"key":"2065_CR84","doi-asserted-by":"publisher","first-page":"117037","DOI":"10.1016\/j.lfs.2019.117037","volume":"239","author":"S Golbahari","year":"2019","unstructured":"Golbahari S, Abtahi Froushani SM (2019) Synergistic benefits of nicotine and thymol in alleviating experimental rheumatoid arthritis. Life Sci 239:117037. https:\/\/doi.org\/10.1016\/j.lfs.2019.117037","journal-title":"Life Sci"},{"issue":"17","key":"2065_CR85","doi-asserted-by":"publisher","first-page":"6370","DOI":"10.3390\/molecules28176370","volume":"28","author":"M Guo","year":"2023","unstructured":"Guo M, Qin S, Wang S, Sun M, Yang H, Wang X et al (2023) Herbal medicine nanocrystals: a potential novel therapeutic strategy. Molecules 28(17):6370","journal-title":"Molecules"},{"issue":"1","key":"2065_CR86","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1038\/s41392-024-01757-9","volume":"9","author":"Q Guo","year":"2024","unstructured":"Guo Q, Jin Y, Chen X, Ye X, Shen X, Lin M et al (2024) NF-\u03baB in biology and targeted therapy: new insights and translational implications. Signal Transduct Target Ther 9(1):53. https:\/\/doi.org\/10.1038\/s41392-024-01757-9","journal-title":"Signal Transduct Target Ther"},{"issue":"4","key":"2065_CR87","doi-asserted-by":"publisher","first-page":"657","DOI":"10.22270\/jddt.v9i4.3066","volume":"9","author":"AK Gupta","year":"2019","unstructured":"Gupta AK, Gupta MK, Sharma V (2019) A review on liposome encapsulated curcumin for treatment of arthritis. J Drug Deliv Ther 9(4):657\u2013659","journal-title":"J Drug Deliv Ther"},{"issue":"10","key":"2065_CR88","doi-asserted-by":"publisher","first-page":"6530","DOI":"10.1002\/jcp.26620","volume":"233","author":"L Hamzehzadeh","year":"2018","unstructured":"Hamzehzadeh L, Atkin SL, Majeed M, Butler AE, Sahebkar A (2018) The versatile role of curcumin in cancer prevention and treatment: a focus on PI3K\/AKT pathway (review). J Cell Physiol 233(10):6530\u20136537. https:\/\/doi.org\/10.1002\/jcp.26620","journal-title":"J Cell Physiol"},{"issue":"4","key":"2065_CR89","doi-asserted-by":"publisher","first-page":"1726","DOI":"10.1016\/j.apsb.2022.11.020","volume":"13","author":"Z Han","year":"2023","unstructured":"Han Z, Gao X, Wang Y, Cheng S, Zhong X, Xu Y et al (2023) Ultrasmall iron-quercetin metal natural product nanocomplex with antioxidant and macrophage regulation in rheumatoid arthritis. Acta Pharm Sin B 13(4):1726\u20131739. https:\/\/doi.org\/10.1016\/j.apsb.2022.11.020","journal-title":"Acta Pharm Sin B"},{"issue":"1","key":"2065_CR90","doi-asserted-by":"publisher","first-page":"287","DOI":"10.1007\/s10787-022-01118-4","volume":"31","author":"A Hannan","year":"2023","unstructured":"Hannan A, Akhtar B, Sharif A, Anjum F, Pasha I, Khan A et al (2023) Quercetin-loaded chitosan nanoparticles ameliorate adjuvant-induced arthritis in rats by regulating anti-oxidant enzymes and downregulating pro- and inflammatory cytokines. Inflammopharmacology 31(1):287\u2013300. https:\/\/doi.org\/10.1007\/s10787-022-01118-4","journal-title":"Inflammopharmacology"},{"issue":"1","key":"2065_CR91","first-page":"765624","volume":"2011","author":"M Hashizume","year":"2011","unstructured":"Hashizume M, Mihara M (2011) The roles of interleukin-6 in the pathogenesis of rheumatoid arthritis. Arthritis 2011(1):765624","journal-title":"Arthritis"},{"issue":"3","key":"2065_CR92","doi-asserted-by":"publisher","first-page":"282","DOI":"10.22038\/ijbms.2019.32873.7852","volume":"22","author":"M Hatamipour","year":"2019","unstructured":"Hatamipour M, Sahebkar A, Alavizadeh SH, Dorri M, Jaafari MR (2019) Novel nanomicelle formulation to enhance bioavailability and stability of curcuminoids (article). Iran J Basic Med Sci 22(3):282\u2013289. https:\/\/doi.org\/10.22038\/ijbms.2019.32873.7852","journal-title":"Iran J Basic Med Sci"},{"key":"2065_CR93","doi-asserted-by":"publisher","first-page":"357","DOI":"10.1166\/jbn.2021.3022","volume":"17","author":"L He","year":"2021","unstructured":"He L, Zeng Y, Qin X, Pan L, Chen T, Wang Q et al (2021) Delivery of ferulic acid with PEGylated diphenylalanine nanoparticles for pre-arthritis therapy. J Biomed Nanotechnol 17:357\u2013368","journal-title":"J Biomed Nanotechnol"},{"issue":"6","key":"2065_CR94","doi-asserted-by":"publisher","first-page":"578","DOI":"10.1111\/j.1365-2796.2010.02260.x","volume":"268","author":"M Holmqvist","year":"2010","unstructured":"Holmqvist M, Wedren S, Jacobsson L, Klareskog L, Nyberg F, Rantap\u00e4\u00e4-Dahlqvist S et al (2010) Rapid increase in myocardial infarction risk following diagnosis of rheumatoid arthritis amongst patients diagnosed between 1995 and 2006. J Intern Med 268(6):578\u2013585","journal-title":"J Intern Med"},{"issue":"1","key":"2065_CR95","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1016\/j.advms.2017.06.004","volume":"63","author":"M Hoxha","year":"2018","unstructured":"Hoxha M (2018) A systematic review on the role of eicosanoid pathways in rheumatoid arthritis. Adv Med Sci 63(1):22\u201329","journal-title":"Adv Med Sci"},{"key":"2065_CR96","doi-asserted-by":"publisher","first-page":"1147","DOI":"10.1016\/j.biopha.2017.08.120","volume":"95","author":"M Hu","year":"2017","unstructured":"Hu M, Yuan X, Liu Y, Tang S, Miao J, Zhou Q et al (2017) IL-1beta-induced NF-kappaB activation down-regulates miR-506 expression to promotes osteosarcoma cell growth through JAG1. Biomed Pharmacother 95:1147\u20131155. https:\/\/doi.org\/10.1016\/j.biopha.2017.08.120","journal-title":"Biomed Pharmacother"},{"issue":"9","key":"2065_CR97","doi-asserted-by":"publisher","first-page":"e22373","DOI":"10.1002\/jbt.22373","volume":"33","author":"D Huimin","year":"2019","unstructured":"Huimin D, Hui C, Guowei S, Shouyun X, Junyang P, Juncheng W (2019) Protective effect of betulinic acid on Freund\u2019s complete adjuvant-induced arthritis in rats. J Biochem Mol Toxicol 33(9):e22373","journal-title":"J Biochem Mol Toxicol"},{"issue":"3","key":"2065_CR98","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1002\/em.20474","volume":"50","author":"M Iciek","year":"2009","unstructured":"Iciek M, Kwiecie\u0144 I, W\u0142odek L (2009) Biological properties of garlic and garlic-derived organosulfur compounds. Environ Mol Mutagen 50(3):247\u2013265","journal-title":"Environ Mol Mutagen"},{"issue":"2","key":"2065_CR99","doi-asserted-by":"publisher","first-page":"102741","DOI":"10.1016\/j.autrev.2020.102741","volume":"20","author":"D Ilchovska","year":"2021","unstructured":"Ilchovska D, Barrow DM (2021) An overview of the NF-kB mechanism of pathophysiology in rheumatoid arthritis, investigation of the NF-kB ligand RANKL and related nutritional interventions. Autoimmun Rev 20(2):102741. https:\/\/doi.org\/10.1016\/j.autrev.2020.102741","journal-title":"Autoimmun Rev"},{"issue":"3\u20134","key":"2065_CR100","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1016\/j.phymed.2009.05.020","volume":"17","author":"M Iranshahi","year":"2010","unstructured":"Iranshahi M, Sahebkar A, Hosseini ST, Takasaki M, Konoshima T, Tokuda H (2010) Cancer chemopreventive activity of diversin from Ferula diversivittata in vitro and in vivo (article). Phytomedicine 17(3\u20134):269\u2013273. https:\/\/doi.org\/10.1016\/j.phymed.2009.05.020","journal-title":"Phytomedicine"},{"issue":"5","key":"2065_CR101","doi-asserted-by":"publisher","first-page":"412","DOI":"10.1097\/CEJ.0b013e32832c389e","volume":"18","author":"M Iranshahi","year":"2009","unstructured":"Iranshahi M, Sahebkar A, Takasaki M, Konoshima T, Tokuda H (2009) Cancer chemopreventive activity of the prenylated coumarin, umbelliprenin, in vivo (article). Eur J Cancer Prev 18(5):412\u2013415. https:\/\/doi.org\/10.1097\/CEJ.0b013e32832c389e","journal-title":"Eur J Cancer Prev"},{"issue":"5","key":"2065_CR102","doi-asserted-by":"publisher","first-page":"636","DOI":"10.1016\/j.fct.2005.11.003","volume":"44","author":"R Isbrucker","year":"2006","unstructured":"Isbrucker R, Edwards J, Wolz E, Davidovich A, Bausch J (2006) Safety studies on epigallocatechin gallate (EGCG) preparations. Part 2: dermal, acute and short-term toxicity studies. Food Chem Toxicol 44(5):636\u2013650","journal-title":"Food Chem Toxicol"},{"issue":"1","key":"2065_CR103","first-page":"139","volume":"24","author":"AA Issilbayeva","year":"2022","unstructured":"Issilbayeva AA, Ainabekova BA (2022) Genetic associations with rheumatoid arthritis susceptibility. Rev Hay\u043aa \u0438 \u0417\u0434pa\u0432ooxpa\u043de\u043d\u0438e 24(1):139\u2013146","journal-title":"Rev Hay\u043aa \u0438 \u0417\u0434pa\u0432ooxpa\u043de\u043d\u0438e"},{"issue":"2","key":"2065_CR104","doi-asserted-by":"publisher","first-page":"6637","DOI":"10.21608\/ejhm.2022.270744","volume":"89","author":"MD Jaaffer","year":"2022","unstructured":"Jaaffer MD, Al-Ogaidi IAZ (2022) Developing gold-resveratrol nanoconjugates for management of rheumatoid arthritis (RA). Egypt J Hosp Med 89(2):6637\u20136645","journal-title":"Egypt J Hosp Med"},{"key":"2065_CR105","doi-asserted-by":"publisher","first-page":"168","DOI":"10.1007\/s00011-006-0067-z","volume":"55","author":"J Jackson","year":"2006","unstructured":"Jackson J, Higo T, Hunter W, Burt H (2006) The antioxidants curcumin and quercetin inhibit inflammatory processes associated with arthritis. Inflamm Res 55:168\u2013175","journal-title":"Inflamm Res"},{"issue":"10","key":"2065_CR106","doi-asserted-by":"publisher","first-page":"1285","DOI":"10.1038\/aps.2012.77","volume":"33","author":"V Jan\u010dinov\u00e1","year":"2012","unstructured":"Jan\u010dinov\u00e1 V, Pere\u010dko T, Nos\u00e1\u013e R, Harmatha J, Dr\u00e1bikov\u00e1 K (2012) The natural stilbenoid pinosylvin and activated neutrophils: effects on oxidative burst, protein kinase C, apoptosis and efficiency in adjuvant arthritis. Acta Pharmacol Sin 33(10):1285\u20131292","journal-title":"Acta Pharmacol Sin"},{"issue":"1","key":"2065_CR14","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1080\/07315724.2016.1140093","volume":"36","author":"F Javadi","year":"2017","unstructured":"Javadi F, Ahmadzadeh A, Eghtesadi S, Aryaeian N, Zabihiyeganeh M, Rahimi Foroushani A, Jazayeri S (2017) The effect of Quercetin on inflammatory factors and clinical symptoms in women with Rheumatoid Arthritis: a double-blind, randomized controlled trial. J Am Coll Nutr 36(1):9\u201315","journal-title":"J Am Coll Nutr"},{"issue":"10","key":"2065_CR107","doi-asserted-by":"publisher","first-page":"1857","DOI":"10.1111\/1756-185X.13688","volume":"22","author":"M Javadi","year":"2019","unstructured":"Javadi M, Khadem Haghighian H, Goodarzy S, Abbasi M, Nassiri-Asl M (2019) Effect of curcumin nanomicelle on the clinical symptoms of patients with rheumatoid arthritis: a randomized, double-blind, controlled trial. Int J Rheum Dis 22(10):1857\u20131862","journal-title":"Int J Rheum Dis"},{"issue":"1\u20132","key":"2065_CR108","doi-asserted-by":"publisher","first-page":"222","DOI":"10.1016\/j.ijpharm.2016.04.052","volume":"506","author":"MK Jeengar","year":"2016","unstructured":"Jeengar MK, Rompicharla SVK, Shrivastava S, Chella N, Shastri NR, Naidu V et al (2016) Emu oil based nano-emulgel for topical delivery of curcumin. Int J Pharm 506(1\u20132):222\u2013236","journal-title":"Int J Pharm"},{"key":"2065_CR109","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1016\/j.colsurfb.2013.07.065","volume":"112","author":"R Jeyadevi","year":"2013","unstructured":"Jeyadevi R, Sivasudha T, Rameshkumar A, Ananth DA, Aseervatham GSB, Kumaresan K et al (2013) Enhancement of anti arthritic effect of quercetin using thioglycolic acid-capped cadmium telluride quantum dots as nanocarrier in adjuvant induced arthritic Wistar rats. Colloids Surf B Biointerfaces 112:255\u2013263. https:\/\/doi.org\/10.1016\/j.colsurfb.2013.07.065","journal-title":"Colloids Surf B Biointerfaces"},{"key":"2065_CR110","doi-asserted-by":"publisher","first-page":"113718","DOI":"10.1016\/j.jconrel.2025.113718","volume":"382","author":"H Jiang","year":"2025","unstructured":"Jiang H, Lu Q, Huang X, Zhang H, Zeng J, Wang M et al (2025) Sinomenine-glycyrrhizic acid self-assembly enhanced the anti-inflammatory effect of sinomenine in the treatment of rheumatoid arthritis. J Control Release 382:113718. https:\/\/doi.org\/10.1016\/j.jconrel.2025.113718","journal-title":"J Control Release"},{"issue":"1","key":"2065_CR111","first-page":"25","volume":"8","author":"H Jiang","year":"2009","unstructured":"Jiang H, Shang X, Wu H, Gautam SC, Al-Holou S, Li C et al (2009) Resveratrol downregulates PI3K\/Akt\/mTOR signaling pathways in human U251 glioma cells. J Exp Ther Oncol 8(1):25","journal-title":"J Exp Ther Oncol"},{"key":"2065_CR112","doi-asserted-by":"publisher","first-page":"107879","DOI":"10.1016\/j.intimp.2021.107879","volume":"98","author":"M Jing","year":"2021","unstructured":"Jing M, Yang J, Zhang L, Liu J, Xu S, Wang M et al (2021) Celastrol inhibits rheumatoid arthritis through the ROS-NF-\u03baB-NLRP3 inflammasome axis. Int Immunopharmacol 98:107879","journal-title":"Int Immunopharmacol"},{"key":"2065_CR113","doi-asserted-by":"publisher","first-page":"152825","DOI":"10.1016\/j.phymed.2019.152825","volume":"58","author":"R Jing","year":"2019","unstructured":"Jing R, Ban Y, Xu W, Nian H, Guo Y, Geng Y et al (2019) Therapeutic effects of the total lignans from Vitex negundo seeds on collagen-induced arthritis in rats. Phytomedicine 58:152825. https:\/\/doi.org\/10.1016\/j.phymed.2019.152825","journal-title":"Phytomedicine"},{"issue":"2","key":"2065_CR114","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1038\/s41584-018-0123-4","volume":"15","author":"IA Jones","year":"2019","unstructured":"Jones IA, Togashi R, Wilson ML, Heckmann N, Vangsness CT Jr (2019) Intra-articular treatment options for knee osteoarthritis. Nat Rev Rheumatol 15(2):77\u201390","journal-title":"Nat Rev Rheumatol"},{"issue":"5","key":"2065_CR115","doi-asserted-by":"publisher","first-page":"566","DOI":"10.3390\/antiox13050566","volume":"13","author":"PJL Juiz","year":"2024","unstructured":"Juiz PJL, Ferreira LTB, Pires EA, Villarreal CF (2024) Patent mining on the use of antioxidant phytochemicals in the technological development for the prevention and treatment of periodontitis. Antioxidants (Basel) 13(5):566","journal-title":"Antioxidants (Basel)"},{"key":"2065_CR116","doi-asserted-by":"publisher","first-page":"104801","DOI":"10.1016\/j.jddst.2023.104801","volume":"87","author":"V Kadian","year":"2023","unstructured":"Kadian V, Rao R (2023) Exploring the in vitro anti-arthritic potential of capsaicin-coordinated \u03b2-cyclodextrin nanosponges. J Drug Deliv Sci Technol 87:104801. https:\/\/doi.org\/10.1016\/j.jddst.2023.104801","journal-title":"J Drug Deliv Sci Technol"},{"key":"2065_CR117","doi-asserted-by":"publisher","first-page":"118560","DOI":"10.1016\/j.ijpharm.2019.118560","volume":"569","author":"R Kamel","year":"2019","unstructured":"Kamel R, Abbas H, Shaffie NM (2019) Development and evaluation of PLA-coated co-micellar nanosystem of Resveratrol for the intra-articular treatment of arthritis. Int J Pharm 569:118560. https:\/\/doi.org\/10.1016\/j.ijpharm.2019.118560","journal-title":"Int J Pharm"},{"key":"2065_CR118","doi-asserted-by":"publisher","first-page":"192","DOI":"10.1016\/j.tifs.2021.11.032","volume":"119","author":"K Kandemir","year":"2022","unstructured":"Kandemir K, Tomas M, McClements DJ, Capanoglu E (2022) Recent advances on the improvement of quercetin bioavailability. Trends Food Sci Technol 119:192\u2013200. https:\/\/doi.org\/10.1016\/j.tifs.2021.11.032","journal-title":"Trends Food Sci Technol"},{"issue":"37","key":"2065_CR119","doi-asserted-by":"publisher","first-page":"e30413","DOI":"10.1097\/MD.0000000000030413","volume":"101","author":"D-Y Kang","year":"2022","unstructured":"Kang D-Y, Kim H, Kim K-W, Chung W-S (2022) Bibliometric analysis of research relating to the use of herbal medicine for rheumatoid arthritis between 1991 to 2021. Medicine (Baltimore) 101(37):e30413","journal-title":"Medicine (Baltimore)"},{"key":"2065_CR120","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1016\/j.cytogfr.2016.10.001","volume":"33","author":"MS Karimian","year":"2017","unstructured":"Karimian MS, Pirro M, Majeed M, Sahebkar A (2017) Curcumin as a natural regulator of monocyte chemoattractant protein-1 (review). Cytokine Growth Factor Rev 33:55\u201363. https:\/\/doi.org\/10.1016\/j.cytogfr.2016.10.001","journal-title":"Cytokine Growth Factor Rev"},{"issue":"3","key":"2065_CR121","doi-asserted-by":"publisher","first-page":"1705","DOI":"10.1007\/s10787-024-01445-8","volume":"32","author":"C Kaur","year":"2024","unstructured":"Kaur C, Mishra Y, Kumar R, Singh G, Singh S, Mishra V et al (2024) Pathophysiology, diagnosis, and herbal medicine-based therapeutic implication of rheumatoid arthritis: an overview. Inflammopharmacology 32(3):1705\u20131720","journal-title":"Inflammopharmacology"},{"key":"2065_CR122","doi-asserted-by":"publisher","unstructured":"Khare V, Saxena AK, Gupta PN (2015) Chapter 15\u2014Toxicology considerations in nanomedicine. In Thomas S, Grohens Y, Ninan N (Eds.), Nanotechnology Applications for Tissue Engineering (pp. 239\u2013261). Oxford: William Andrew Publishing. https:\/\/doi.org\/10.1016\/B978-0-323-32889-0.00015-7","DOI":"10.1016\/B978-0-323-32889-0.00015-7"},{"key":"2065_CR123","doi-asserted-by":"publisher","first-page":"2035","DOI":"10.1007\/s10067-018-4080-8","volume":"37","author":"HM Khojah","year":"2018","unstructured":"Khojah HM, Ahmed S, Abdel-Rahman MS, Elhakeim EH (2018) Resveratrol as an effective adjuvant therapy in the management of rheumatoid arthritis: a clinical study. Clin Rheumatol 37:2035\u20132042","journal-title":"Clin Rheumatol"},{"issue":"4","key":"2065_CR124","doi-asserted-by":"publisher","first-page":"216","DOI":"10.1016\/j.mpmed.2018.01.006","volume":"46","author":"PD Kiely","year":"2018","unstructured":"Kiely PD, Nikiphorou E (2018) Management of rheumatoid arthritis. Medicine (Baltimore) 46(4):216\u2013221","journal-title":"Medicine (Baltimore)"},{"issue":"1\u20133","key":"2065_CR125","doi-asserted-by":"publisher","first-page":"124","DOI":"10.1016\/j.ejphar.2011.04.033","volume":"661","author":"Y Kimura","year":"2011","unstructured":"Kimura Y, Sumiyoshi M (2011) Effects of baicalein and wogonin isolated from Scutellaria baicalensis roots on skin damage in acute UVB-irradiated hairless mice. Eur J Pharmacol 661(1\u20133):124\u2013132","journal-title":"Eur J Pharmacol"},{"key":"2065_CR126","doi-asserted-by":"publisher","first-page":"1121655","DOI":"10.3389\/fimmu.2023.1121655","volume":"14","author":"H Kou","year":"2023","unstructured":"Kou H, Huang L, Jin M, He Q, Zhang R, Ma J (2023a) Effect of curcumin on rheumatoid arthritis: a systematic review and meta-analysis. Front Immunol 14:1121655","journal-title":"Front Immunol"},{"key":"2065_CR127","doi-asserted-by":"publisher","first-page":"1121655","DOI":"10.3389\/fimmu.2023.1121655","volume":"14","author":"H Kou","year":"2023","unstructured":"Kou H, Huang L, Jin M, He Q, Zhang R, Ma J (2023b) Effect of curcumin on rheumatoid arthritis: a systematic review and meta-analysis. Front Immunol 14:1121655. https:\/\/doi.org\/10.3389\/fimmu.2023.1121655","journal-title":"Front Immunol"},{"issue":"9","key":"2065_CR128","doi-asserted-by":"publisher","first-page":"1289","DOI":"10.3390\/biom11091289","volume":"11","author":"K Koushki","year":"2021","unstructured":"Koushki K, Keshavarz Shahbaz S, Keshavarz M, Bezsonov EE, Sathyapalan T, Sahebkar A (2021) Gold nanoparticles: multifaceted roles in the management of autoimmune disorders. Biomolecules 11(9):1289","journal-title":"Biomolecules"},{"key":"2065_CR129","doi-asserted-by":"publisher","first-page":"e00370","DOI":"10.1016\/j.btre.2019.e00370","volume":"24","author":"N Kumar","year":"2019","unstructured":"Kumar N, Goel N (2019) Phenolic acids: natural versatile molecules with promising therapeutic applications. Biotechnol Rep (Amst) 24:e00370","journal-title":"Biotechnol Rep (Amst)"},{"issue":"6","key":"2065_CR130","doi-asserted-by":"publisher","first-page":"609","DOI":"10.1016\/S0367-326X(03)00144-8","volume":"74","author":"Y Kumarasamy","year":"2003","unstructured":"Kumarasamy Y, Middleton M, Reid R, Nahar L, Sarker S (2003) Biological activity of serotonin conjugates from the seeds of Centaurea nigra. Fitoterapia 74(6):609\u2013612","journal-title":"Fitoterapia"},{"key":"2065_CR131","doi-asserted-by":"publisher","first-page":"205873842094507","DOI":"10.1177\/2058738420945078","volume":"34","author":"WJ-Y Kun-Liu","year":"2020","unstructured":"Kun-Liu WJ-Y, Zhang L, Pan Y-Y, Chen X-Y, Yuan Y (2020) Effects of betulinic acid on synovial inflammation in rats with collagen-induced arthritis. Int J Immunopathol Pharmacol 34:2058738420945078","journal-title":"Int J Immunopathol Pharmacol"},{"issue":"6","key":"2065_CR132","doi-asserted-by":"publisher","first-page":"616","DOI":"10.1111\/fcp.12085","volume":"28","author":"V Kuncirova","year":"2014","unstructured":"Kuncirova V, Ponist S, Mihalova D, Drafi F, Nosal R, Acquaviva A et al (2014) N-feruloylserotonin in preventive combination therapy with methotrexate reduced inflammation in adjuvant arthritis. Fundam Clin Pharmacol 28(6):616\u2013626","journal-title":"Fundam Clin Pharmacol"},{"key":"2065_CR133","doi-asserted-by":"publisher","first-page":"170","DOI":"10.1007\/s12016-012-8346-7","volume":"45","author":"J Kurk\u00f3","year":"2013","unstructured":"Kurk\u00f3 J, Besenyei T, Laki J, Glant TT, Mikecz K, Szekanecz Z (2013) Genetics of rheumatoid arthritis\u2014a comprehensive review. Clin Rev Allergy Immunol 45:170\u2013179","journal-title":"Clin Rev Allergy Immunol"},{"issue":"11","key":"2065_CR134","doi-asserted-by":"publisher","first-page":"1779","DOI":"10.1248\/bpb.b13-00430","volume":"36","author":"SC Kwak","year":"2013","unstructured":"Kwak SC, Lee C, Kim J-Y, Oh HM, So H-S, Lee MS et al (2013) Chlorogenic acid inhibits osteoclast differentiation and bone resorption by down-regulation of receptor activator of nuclear factor kappa-B ligand-induced nuclear factor of activated T cells c1 expression. Biol Pharm Bull 36(11):1779\u20131786","journal-title":"Biol Pharm Bull"},{"key":"2065_CR135","doi-asserted-by":"publisher","first-page":"511","DOI":"10.1016\/j.colsurfb.2016.03.060","volume":"143","author":"GH Lee","year":"2016","unstructured":"Lee GH, Lee SJ, Jeong SW, Kim H-C, Park GY, Lee SG et al (2016) Antioxidative and antiinflammatory activities of quercetin-loaded silica nanoparticles. Colloids Surf B Biointerfaces 143:511\u2013517. https:\/\/doi.org\/10.1016\/j.colsurfb.2016.03.060","journal-title":"Colloids Surf B Biointerfaces"},{"key":"2065_CR136","doi-asserted-by":"publisher","first-page":"455","DOI":"10.2119\/2007-00072.Lee","volume":"13","author":"H-S Lee","year":"2007","unstructured":"Lee H-S, Remmers EF, Le JM, Kastner DL, Bae S-C, Gregersen PK (2007) Association of STAT4 with rheumatoid arthritis in the Korean population. Mol Med 13:455\u2013460","journal-title":"Mol Med"},{"issue":"3","key":"2065_CR137","doi-asserted-by":"publisher","first-page":"268","DOI":"10.1016\/j.intimp.2008.11.005","volume":"9","author":"J-D Lee","year":"2009","unstructured":"Lee J-D, Huh J-E, Jeon G, Yang H-R, Woo H-S, Choi D-Y et al (2009) Flavonol-rich RVHxR from Rhus verniciflua Stokes and its major compound fisetin inhibits inflammation-related cytokines and angiogenic factor in rheumatoid arthritic fibroblast-like synovial cells and in vivo models. Int Immunopharmacol 9(3):268\u2013276. https:\/\/doi.org\/10.1016\/j.intimp.2008.11.005","journal-title":"Int Immunopharmacol"},{"key":"2065_CR138","doi-asserted-by":"publisher","first-page":"10627","DOI":"10.1007\/s11033-012-1952-x","volume":"39","author":"YH Lee","year":"2012","unstructured":"Lee YH, Bae S-C, Choi SJ, Ji JD, Song GG (2012) Genome-wide pathway analysis of genome-wide association studies on systemic lupus erythematosus and rheumatoid arthritis. Mol Biol Rep 39:10627\u201310635","journal-title":"Mol Biol Rep"},{"key":"2065_CR139","doi-asserted-by":"publisher","first-page":"186","DOI":"10.1016\/j.intimp.2018.11.042","volume":"67","author":"N Li","year":"2019","unstructured":"Li N, Gong Z, Li X, Ma Q, Wu M, Liu D et al (2019) Betulinic acid inhibits the migration and invasion of fibroblast-like synoviocytes from patients with rheumatoid arthritis. Int Immunopharmacol 67:186\u2013193. https:\/\/doi.org\/10.1016\/j.intimp.2018.11.042","journal-title":"Int Immunopharmacol"},{"issue":"2","key":"2065_CR140","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1211\/jpp.60.2.0011","volume":"60","author":"R Li","year":"2008","unstructured":"Li R, Li J, Cai L, Hu C-M, Zhang L (2008) Suppression of adjuvant arthritis by hesperidin in rats and its mechanisms. J Pharm Pharmacol 60(2):221\u2013228","journal-title":"J Pharm Pharmacol"},{"key":"2065_CR141","doi-asserted-by":"publisher","DOI":"10.2147\/IJN.S457004","author":"X Li","year":"2024","unstructured":"Li X, Wang X, Qu X, Shi N, Li Q, Yan Z et al (2024) Microenvironmental enzyme-responsive methotrexate modified quercetin micelles for the treatment of rheumatoid arthritis. Int J Nanomed. https:\/\/doi.org\/10.2147\/IJN.S457004","journal-title":"Int J Nanomed"},{"issue":"3","key":"2065_CR142","doi-asserted-by":"publisher","first-page":"167","DOI":"10.3390\/nu8030167","volume":"8","author":"Y Li","year":"2016","unstructured":"Li Y, Yao J, Han C, Yang J, Chaudhry MT, Wang S et al (2016) Quercetin, inflammation and immunity. Nutrients 8(3):167","journal-title":"Nutrients"},{"key":"2065_CR143","doi-asserted-by":"publisher","first-page":"132","DOI":"10.1016\/j.intimp.2019.03.024","volume":"71","author":"JJ Liang","year":"2019","unstructured":"Liang JJ, Li HR, Chen Y, Zhang C, Chen DG, Liang ZC et al (2019) Diallyl trisulfide can induce fibroblast-like synovial apoptosis and has a therapeutic effect on collagen-induced arthritis in mice via blocking NF-\u03baB and Wnt pathways. Int Immunopharmacol 71:132\u2013138. https:\/\/doi.org\/10.1016\/j.intimp.2019.03.024","journal-title":"Int Immunopharmacol"},{"issue":"6","key":"2065_CR144","doi-asserted-by":"publisher","first-page":"6998","DOI":"10.1007\/s12035-024-04634-2","volume":"62","author":"H Liao","year":"2025","unstructured":"Liao H, Zheng J, Lu J, Shen H-L (2025) NF-\u03baB signaling pathway in rheumatoid arthritis: mechanisms and therapeutic potential. Mol Neurobiol 62(6):6998\u20137021. https:\/\/doi.org\/10.1007\/s12035-024-04634-2","journal-title":"Mol Neurobiol"},{"issue":"1","key":"2065_CR145","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1111\/j.1749-6632.2010.05846.x","volume":"1215","author":"HY Lin","year":"2011","unstructured":"Lin HY, Tang HY, Davis FB, Davis PJ (2011) Resveratrol and apoptosis. Ann N Y Acad Sci 1215(1):79\u201388","journal-title":"Ann N Y Acad Sci"},{"key":"2065_CR146","doi-asserted-by":"publisher","unstructured":"Liu J, Wang C, Wang Q, Zhang W, Li Z, He S et al (2023a) Chapter 27\u2014Triterpenoids and saponins in drug discovery. In Yu B, Li N, Fu C (Eds.), Privileged Scaffolds in drug discovery (pp. 613\u2013671). Academic Press. https:\/\/doi.org\/10.1016\/B978-0-443-18611-0.00013-9","DOI":"10.1016\/B978-0-443-18611-0.00013-9"},{"key":"2065_CR147","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1016\/j.colsurfb.2013.11.029","volume":"115","author":"L Liu","year":"2014","unstructured":"Liu L, Tang Y, Gao C, Li Y, Chen S, Xiong T et al (2014) Characterization and biodistribution in vivo of quercetin-loaded cationic nanostructured lipid carriers. Colloids Surf B Biointerfaces 115:125\u2013131. https:\/\/doi.org\/10.1016\/j.colsurfb.2013.11.029","journal-title":"Colloids Surf B Biointerfaces"},{"issue":"2","key":"2065_CR148","doi-asserted-by":"publisher","first-page":"e782","DOI":"10.1002\/iid3.782","volume":"11","author":"S Liu","year":"2023","unstructured":"Liu S, Li J, Feng LH (2023b) Gallic acid regulates immune response in a mouse model of rheumatoid arthritis. Immun Inflamm Dis 11(2):e782. https:\/\/doi.org\/10.1002\/iid3.782","journal-title":"Immun Inflamm Dis"},{"key":"2065_CR149","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1016\/j.ejphar.2016.10.004","volume":"794","author":"Y Liu","year":"2017","unstructured":"Liu Y, Sun Z, Xu D, Liu J, Li X, Wu X et al (2017) Hesperidin derivative-11 inhibits fibroblast-like synoviocytes proliferation by activating Secreted frizzled-related protein 2 in adjuvant arthritis rats. Eur J Pharmacol 794:173\u2013183. https:\/\/doi.org\/10.1016\/j.ejphar.2016.10.004","journal-title":"Eur J Pharmacol"},{"key":"2065_CR150","doi-asserted-by":"publisher","first-page":"104409","DOI":"10.1016\/j.phrs.2019.104409","volume":"148","author":"C Luo","year":"2019","unstructured":"Luo C, Xu X, Wei X, Feng W, Huang H, Liu H et al (2019) Natural medicines for the treatment of fatigue: bioactive components, pharmacology, and mechanisms. Pharmacol Res 148:104409","journal-title":"Pharmacol Res"},{"issue":"6","key":"2065_CR151","doi-asserted-by":"publisher","first-page":"1078","DOI":"10.1136\/annrheumdis-2013-204807","volume":"74","author":"Q-w Lv","year":"2015","unstructured":"Lv Q-w, Zhang W, Shi Q, Zheng W-j, Li X, Chen H et al (2015) Comparison of Tripterygium wilfordii Hook F with methotrexate in the treatment of active rheumatoid arthritis (TRIFRA): a randomised, controlled clinical trial. Ann Rheum Dis 74(6):1078\u20131086","journal-title":"Ann Rheum Dis"},{"issue":"2","key":"2065_CR152","doi-asserted-by":"publisher","first-page":"385","DOI":"10.1089\/jmf.2007.514","volume":"11","author":"D Ly","year":"2008","unstructured":"Ly D, Kang K, Choi J-Y, Ishihara A, Back K, Lee S-G (2008) HPLC analysis of serotonin, tryptamine, tyramine, and the hydroxycinnamic acid amides of serotonin and tyramine in food vegetables. J Med Food 11(2):385\u2013389","journal-title":"J Med Food"},{"issue":"6","key":"2065_CR153","doi-asserted-by":"publisher","first-page":"3615","DOI":"10.3892\/mmr.2017.6484","volume":"15","author":"A Ma","year":"2017","unstructured":"Ma A, Yang Y, Wang Q, Wang Y, Wen J, Zhang Y (2017) Anti-inflammatory effects of oxymatrine on rheumatoid arthritis in rats via regulating the imbalance between Treg and Th17 cells. Mol Med Rep 15(6):3615\u20133622","journal-title":"Mol Med Rep"},{"issue":"5","key":"2065_CR154","doi-asserted-by":"publisher","first-page":"383","DOI":"10.1080\/03009742.2019.1600716","volume":"48","author":"X Ma","year":"2019","unstructured":"Ma X, Chen G, Wang J, Xu J, Zhao F, Hu M et al (2019) Pedunculoside attenuates pathological phenotypes of fibroblast-like synoviocytes and protects against collagen-induced arthritis. Scand J Rheumatol 48(5):383\u2013392","journal-title":"Scand J Rheumatol"},{"key":"2065_CR155","doi-asserted-by":"publisher","first-page":"2356","DOI":"10.1007\/s10904-019-01421-8","volume":"30","author":"Y Ma","year":"2020","unstructured":"Ma Y, Song Y, Ma F, Chen G (2020) A potential polymeric nanogel system for effective delivery of chlorogenic acid to target collagen-induced arthritis. J Inorg Organomet Polym Mater 30:2356\u20132365","journal-title":"J Inorg Organomet Polym Mater"},{"issue":"3","key":"2065_CR156","doi-asserted-by":"publisher","first-page":"277","DOI":"10.1016\/j.ctrv.2015.01.001","volume":"41","author":"MA Macha","year":"2015","unstructured":"Macha MA, Krishn SR, Jahan R, Banerjee K, Batra SK, Jain M (2015) Emerging potential of natural products for targeting mucins for therapy against inflammation and cancer. Cancer Treat Rev 41(3):277\u2013288. https:\/\/doi.org\/10.1016\/j.ctrv.2015.01.001","journal-title":"Cancer Treat Rev"},{"issue":"2","key":"2065_CR157","first-page":"91","volume":"31","author":"T Ma\u010di\u010dkov\u00e1","year":"2010","unstructured":"Ma\u010di\u010dkov\u00e1 T, Dr\u00e1bikov\u00e1 K, Nosal R, Bauerov\u00e1 K, Mih\u00e1lov\u00e1 D, Harmatha J et al (2010) In vivo effect of pinosylvin and pterostilbene in the animal model of adjuvant arthritis. Neuroendocrinol Lett 31(2):91","journal-title":"Neuroendocrinol Lett"},{"key":"2065_CR158","doi-asserted-by":"publisher","first-page":"101666","DOI":"10.1016\/j.jddst.2020.101666","volume":"57","author":"S Majumdar","year":"2020","unstructured":"Majumdar S, Dey S, Ganguly D, Mazumder R (2020) Enhanced topical permeability of natural flavonoid baicalein through nano liposomal gel: in vitro and in vivo investigation. J Drug Deliv Sci Technol 57:101666. https:\/\/doi.org\/10.1016\/j.jddst.2020.101666","journal-title":"J Drug Deliv Sci Technol"},{"key":"2065_CR159","doi-asserted-by":"publisher","unstructured":"Manoharlal R, Saiprasad GVS, Dwivedi SD, Singh MR, Singh D (2023) Chapter 12\u2014Commercial aspect and market potential of phytoactive products. In Singh MR, Singh D (Eds.), Phytopharmaceuticals and herbal drugs (pp. 281\u2013301). Academic Press. https:\/\/doi.org\/10.1016\/B978-0-323-99125-4.00012-3","DOI":"10.1016\/B978-0-323-99125-4.00012-3"},{"issue":"3","key":"2065_CR160","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1093\/rheumatology\/41.3.329","volume":"41","author":"H Matsuno","year":"2002","unstructured":"Matsuno H, Yudoh K, Katayama R, Nakazawa F, Uzuki M, Sawai T et al (2002) The role of TNF\u2010\u03b1 in the pathogenesis of inflammation and joint destruction in rheumatoid arthritis (RA): a study using a human RA\/SCID mouse chimera. Rheumatology 41(3):329\u2013337","journal-title":"Rheumatology"},{"issue":"4","key":"2065_CR161","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1016\/j.acvd.2010.03.007","volume":"103","author":"C Meune","year":"2010","unstructured":"Meune C, Touz\u00e9 E, Trinquart L, Allanore Y (2010) High risk of clinical cardiovascular events in rheumatoid arthritis: levels of associations of myocardial infarction and stroke through a systematic review and meta-analysis. Arch Cardiovasc Dis 103(4):253\u2013261","journal-title":"Arch Cardiovasc Dis"},{"issue":"18","key":"2065_CR162","doi-asserted-by":"publisher","first-page":"1867","DOI":"10.2174\/1389557520666200807133022","volume":"20","author":"N Mirrezaei","year":"2020","unstructured":"Mirrezaei N, Yazdian-Robati R, Oroojalian F, Sahebkar A, Hashemi M (2020) Recent developments in nano-drug delivery systems loaded by phytochemicals for wound healing. Mini Rev Med Chem 20(18):1867\u20131878","journal-title":"Mini Rev Med Chem"},{"key":"2065_CR163","doi-asserted-by":"publisher","first-page":"174504","DOI":"10.1016\/j.ejphar.2021.174504","volume":"910","author":"M Mittal","year":"2021","unstructured":"Mittal M, Mehta P, Rajput S, Rajender S, Chattopadhyay N (2021) The pharmacological assessment of resveratrol on preclinical models of rheumatoid arthritis through a systematic review and meta-analysis. Eur J Pharmacol 910:174504. https:\/\/doi.org\/10.1016\/j.ejphar.2021.174504","journal-title":"Eur J Pharmacol"},{"issue":"1","key":"2065_CR164","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1007\/s40097-021-00398-6","volume":"12","author":"FA Moghaddam","year":"2022","unstructured":"Moghaddam FA, Ebrahimian M, Oroojalian F, Yazdian-Robati R, Kalalinia F, Tayebi L et al (2022) Effect of thymoquinone-loaded lipid\u2013polymer nanoparticles as an oral delivery system on anticancer efficiency of doxorubicin. J Nanostruct Chem 12(1):33\u201344","journal-title":"J Nanostruct Chem"},{"key":"2065_CR165","doi-asserted-by":"crossref","unstructured":"Mohammadian Haftcheshmeh S, Khosrojerdi A, Aliabadi A, Lotfi S, Mohammadi A, Momtazi-Borojeni AA (2021) Immunomodulatory effects of curcumin in rheumatoid arthritis: evidence from molecular mechanisms to clinical outcomes. Rev Physiol Biochem Pharmacol 1\u201329","DOI":"10.1007\/112_2020_54"},{"issue":"43","key":"2065_CR166","doi-asserted-by":"publisher","first-page":"28630","DOI":"10.1021\/acsomega.1c03066","volume":"6","author":"S Mohanty","year":"2021","unstructured":"Mohanty S, Konkimalla VB, Pal A, Sharma T, Si SC (2021) Naringin as sustained delivery nanoparticles ameliorates the anti-inflammatory activity in a Freund\u2019s complete adjuvant-induced arthritis model. ACS Omega 6(43):28630\u201328641","journal-title":"ACS Omega"},{"issue":"4","key":"2065_CR167","doi-asserted-by":"publisher","first-page":"335","DOI":"10.1007\/s40291-016-0202-7","volume":"20","author":"AA Momtazi-Borojeni","year":"2016","unstructured":"Momtazi-Borojeni AA, Derosa G, Maffioli P, Banach M, Sahebkar A (2016) Role of microRNAs in the therapeutic effects of curcumin in non-cancer diseases (review). Mol Diagn Ther 20(4):335\u2013345. https:\/\/doi.org\/10.1007\/s40291-016-0202-7","journal-title":"Mol Diagn Ther"},{"issue":"11","key":"2065_CR168","doi-asserted-by":"publisher","first-page":"2953","DOI":"10.1002\/ptr.6723","volume":"34","author":"SP Moosavian","year":"2020","unstructured":"Moosavian SP, Paknahad Z, Habibagahi Z, Maracy M (2020) The effects of garlic (Allium sativum) supplementation on inflammatory biomarkers, fatigue, and clinical symptoms in patients with active rheumatoid arthritis: a randomized, double-blind, placebo-controlled trial. Phytother Res 34(11):2953\u20132962","journal-title":"Phytother Res"},{"key":"2065_CR169","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/ar2969","volume":"12","author":"AW Morgan","year":"2010","unstructured":"Morgan AW, Robinson JI, Conaghan PG, Martin SG, Hensor EM, Morgan MD et al (2010) Evaluation of the rheumatoid arthritis susceptibility loci HLA-DRB1, PTPN22, OLIG3\/TNFAIP3, STAT4 and TRAF1\/C5 in an inception cohort. Arthritis Res Ther 12:1\u201310","journal-title":"Arthritis Res Ther"},{"issue":"1","key":"2065_CR170","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1517\/14740338.2016.1112375","volume":"15","author":"G Murdaca","year":"2016","unstructured":"Murdaca G, Span\u00f2 F, Contatore M, Guastalla A, Penza E, Magnani O et al (2016) Immunogenicity of infliximab and adalimumab: what is its role in hypersensitivity and modulation of therapeutic efficacy and safety? Exp Opin Drug Saf 15(1):43\u201352. https:\/\/doi.org\/10.1517\/14740338.2016.1112375","journal-title":"Exp Opin Drug Saf"},{"issue":"6","key":"2065_CR171","doi-asserted-by":"publisher","first-page":"801","DOI":"10.1517\/14740338.2013.823947","volume":"12","author":"G Murdaca","year":"2013","unstructured":"Murdaca G, Span\u00f2 F, Puppo F (2013) Use of leflunomide plus TNF-\u03b1 inhibitors in rheumatoid arthritis. Expert Opin Drug Saf 12(6):801\u2013804. https:\/\/doi.org\/10.1517\/14740338.2013.823947","journal-title":"Expert Opin Drug Saf"},{"issue":"11","key":"2065_CR172","doi-asserted-by":"publisher","first-page":"1423","DOI":"10.1248\/cpb.58.1423","volume":"58","author":"K Nagpal","year":"2010","unstructured":"Nagpal K, Singh SK, Mishra DN (2010) Chitosan nanoparticles: a promising system in novel drug delivery. Chem Pharm Bull 58(11):1423\u20131430","journal-title":"Chem Pharm Bull"},{"issue":"7","key":"2065_CR173","doi-asserted-by":"publisher","first-page":"1406","DOI":"10.1002\/mnfr.201400909","volume":"59","author":"K Nakamura","year":"2015","unstructured":"Nakamura K, Matsuoka H, Nakashima S, Kanda T, Nishimaki-Mogami T, Akiyama H (2015) Oral administration of apple condensed tannins delays rheumatoid arthritis development in mice via downregulation of T helper 17 (Th17) cell responses. Mol Nutr Food Res 59(7):1406\u20131410. https:\/\/doi.org\/10.1002\/mnfr.201400909","journal-title":"Mol Nutr Food Res"},{"key":"2065_CR174","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1007\/s10787-024-01612-x","volume":"33","author":"MM Nazir","year":"2024","unstructured":"Nazir MM, Farzeen I, Fasial S, Ashraf A (2024) Berberine in rheumatoid arthritis: a comprehensive review and meta-analysis of its anti-inflammatory and immunomodulatory mechanisms in animal models. Inflammopharmacology 33:215. https:\/\/doi.org\/10.1007\/s10787-024-01612-x","journal-title":"Inflammopharmacology"},{"issue":"1","key":"2065_CR175","doi-asserted-by":"publisher","first-page":"252","DOI":"10.1111\/j.1600-065X.2008.00648.x","volume":"223","author":"EH Noss","year":"2008","unstructured":"Noss EH, Brenner MB (2008) The role and therapeutic implications of fibroblast\u2010like synoviocytes in inflammation and cartilage erosion in rheumatoid arthritis. Immunol Rev 223(1):252\u2013270","journal-title":"Immunol Rev"},{"key":"2065_CR176","doi-asserted-by":"publisher","first-page":"883857","DOI":"10.3389\/fphar.2022.883857","volume":"13","author":"JF Oliveira-Costa","year":"2022","unstructured":"Oliveira-Costa JF, Meira CS, Neves MVGD, Dos Reis BPZC, Soares MBP (2022) Anti-inflammatory activities of betulinic acid: a review (review). Front Pharmacol 13:883857. https:\/\/doi.org\/10.3389\/fphar.2022.883857","journal-title":"Front Pharmacol"},{"issue":"4","key":"2065_CR177","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1038\/s41584-019-0187-9","volume":"15","author":"O-O Olumuyiwa-Akeredolu","year":"2019","unstructured":"Olumuyiwa-Akeredolu O-O, Page MJ, Soma P, Pretorius E (2019) Platelets: emerging facilitators of cellular crosstalk in rheumatoid arthritis. Nat Rev Rheumatol 15(4):237\u2013248","journal-title":"Nat Rev Rheumatol"},{"key":"2065_CR178","doi-asserted-by":"publisher","first-page":"174380","DOI":"10.1016\/j.ejphar.2021.174380","volume":"908","author":"M Omraninava","year":"2021","unstructured":"Omraninava M, Razi B, Aslani S, Imani D, Jamialahmadi T, Sahebkar A (2021) Effect of resveratrol on inflammatory cytokines: a meta-analysis of randomized controlled trials. Eur J Pharmacol 908:174380. https:\/\/doi.org\/10.1016\/j.ejphar.2021.174380","journal-title":"Eur J Pharmacol"},{"issue":"1","key":"2065_CR179","doi-asserted-by":"publisher","first-page":"444","DOI":"10.1074\/jbc.275.1.444","volume":"275","author":"S Onodera","year":"2000","unstructured":"Onodera S, Kaneda K, Mizue Y, Koyama Y, Fujinaga M, Nishihira J (2000) Macrophage migration inhibitory factor up-regulates expression of matrix metalloproteinases in synovial fibroblasts of rheumatoid arthritis. J Biol Chem 275(1):444\u2013450","journal-title":"J Biol Chem"},{"issue":"6","key":"2065_CR180","doi-asserted-by":"publisher","first-page":"8182","DOI":"10.1002\/jcp.27615","volume":"234","author":"MN Oskouie","year":"2019","unstructured":"Oskouie MN, Aghili Moghaddam NS, Butler AE, Zamani P, Sahebkar A (2019) Therapeutic use of curcumin-encapsulated and curcumin-primed exosomes (review). J Cell Physiol 234(6):8182\u20138191. https:\/\/doi.org\/10.1002\/jcp.27615","journal-title":"J Cell Physiol"},{"issue":"1","key":"2065_CR181","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1002\/ptr.5211","volume":"29","author":"Y Panahi","year":"2015","unstructured":"Panahi Y, Badeli R, Karami GR, Sahebkar A (2015) Investigation of the efficacy of adjunctive therapy with bioavailability-boosted curcuminoids in major depressive disorder (article). Phytother Res 29(1):17\u201321. https:\/\/doi.org\/10.1002\/ptr.5211","journal-title":"Phytother Res"},{"issue":"11","key":"2065_CR182","doi-asserted-by":"publisher","first-page":"567","DOI":"10.1055\/s-0034-1389986","volume":"65","author":"Y Panahi","year":"2014","unstructured":"Panahi Y, Ghanei M, Bashiri S, Hajihashemi A, Sahebkar A (2014) Short-term curcuminoid supplementation for chronic pulmonary complications due to sulfur mustard intoxication: positive results of a randomized double-blind placebo-controlled trial (article). Drug Res 65(11):567\u2013573. https:\/\/doi.org\/10.1055\/s-0034-1389986","journal-title":"Drug Res"},{"key":"2065_CR183","doi-asserted-by":"publisher","unstructured":"Panahi Y, Saberi-Karimian M, Valizadeh O, Behnam B, Saadat, A, Jamialahmadi T et al (2021) Effects of curcuminoids on systemic inflammation and quality of life in patients with colorectal cancer undergoing chemotherapy: a randomized controlled trial. Advances in experimental medicine and biology (pp. 1\u20139). https:\/\/doi.org\/10.1007\/978-3-030-73234-9_1","DOI":"10.1007\/978-3-030-73234-9_1"},{"issue":"6","key":"2065_CR184","doi-asserted-by":"publisher","first-page":"580","DOI":"10.1258\/acb.2012.012040","volume":"49","author":"Y Panahi","year":"2012","unstructured":"Panahi Y, Sahebkar A, Parvin S, Saadat A (2012) A randomized controlled trial on the anti-inflammatory effects of curcumin in patients with chronic sulphur mustard-induced cutaneous complications (Article). Ann Clin Biochem 49(6):580\u2013588. https:\/\/doi.org\/10.1258\/acb.2012.012040","journal-title":"Ann Clin Biochem"},{"issue":"11","key":"2065_CR185","doi-asserted-by":"publisher","first-page":"109","DOI":"10.14715\/cmb\/2023.69.11.17","volume":"69","author":"CH Park","year":"2023","unstructured":"Park CH, Han SW, Seong SH, Choi JS, Jeon JP, Yokozawa T (2023) N-feruloylserotonin inhibits lipopolysaccharide-induced inflammation via SIRT1-stimulated FOXO1 and NF-\u03baB signaling pathways in RAW 264.7 cells. Cell Mol Biol 69(11):109\u2013115","journal-title":"Cell Mol Biol"},{"key":"2065_CR186","doi-asserted-by":"publisher","first-page":"105725","DOI":"10.1016\/j.phrs.2021.105725","volume":"170","author":"N Parsamanesh","year":"2021","unstructured":"Parsamanesh N, Asghari A, Sardari S, Tasbandi A, Jamialahmadi T, Xu S et al (2021) Resveratrol and endothelial function: a literature review. Pharmacol Res 170:105725. https:\/\/doi.org\/10.1016\/j.phrs.2021.105725","journal-title":"Pharmacol Res"},{"issue":"6","key":"2065_CR187","doi-asserted-by":"publisher","first-page":"1202","DOI":"10.1016\/j.bbadis.2014.10.006","volume":"1852","author":"GM Pasinetti","year":"2015","unstructured":"Pasinetti GM, Wang J, Ho L, Zhao W, Dubner L (2015) Roles of resveratrol and other grape-derived polyphenols in Alzheimer\u2019s disease prevention and treatment. Biochim Biophys Acta (BBA) Mol Basis Dis 1852(6):1202\u20131208","journal-title":"Biochim Biophys Acta (BBA) Mol Basis Dis"},{"issue":"1","key":"2065_CR188","first-page":"7509653","volume":"2016","author":"\u013d Pa\u0161kov\u00e1","year":"2016","unstructured":"Pa\u0161kov\u00e1 \u013d, Kuncirova V, Poni\u0161t S, Mihalova D, Nos\u00e1\u013e R, Harmatha J et al (2016) Effect of N-feruloylserotonin and methotrexate on severity of experimental arthritis and on messenger RNA expression of key proinflammatory markers in liver. J Immunol Res 2016(1):7509653","journal-title":"J Immunol Res"},{"issue":"2","key":"2065_CR189","doi-asserted-by":"publisher","first-page":"264","DOI":"10.1017\/S0007114508201947","volume":"102","author":"R Piga","year":"2009","unstructured":"Piga R, Naito Y, Kokura S, Handa O, Yoshikawa T (2009) Inhibitory effect of serotonin derivatives on high glucose-induced adhesion and migration of monocytes on human aortic endothelial cells. Br J Nutr 102(2):264\u2013272","journal-title":"Br J Nutr"},{"issue":"12","key":"2065_CR190","doi-asserted-by":"publisher","first-page":"1199","DOI":"10.1056\/NEJMoa073491","volume":"357","author":"RM Plenge","year":"2007","unstructured":"Plenge RM, Seielstad M, Padyukov L, Lee AT, Remmers EF, Ding B et al (2007) TRAF1\u2013C5 as a risk locus for rheumatoid arthritis\u2014a genomewide study. N Engl J Med 357(12):1199\u20131209","journal-title":"N Engl J Med"},{"key":"2065_CR191","doi-asserted-by":"publisher","first-page":"1227","DOI":"10.13005\/bpj\/2458","volume":"15","author":"SA Polshettiwar","year":"2022","unstructured":"Polshettiwar SA, Sawant DH, Abhale NB, Chavan NB, Baheti AM, Wani MS et al (2022) Review on regulation of herbal products used as a medicine across the globe: a case study on turmeric\u2014golden medicine. Biomed Pharmacol J 15:1227\u20131237","journal-title":"Biomed Pharmacol J"},{"issue":"8","key":"2065_CR192","doi-asserted-by":"publisher","first-page":"356","DOI":"10.1089\/adt.2020.989","volume":"18","author":"N Poonia","year":"2020","unstructured":"Poonia N, Lather V, Kaur B, Kirthanashri SV, Pandita D (2020) Optimization and development of methotrexate-and resveratrol-loaded nanoemulsion formulation using box\u2013behnken design for rheumatoid arthritis. Assay Drug Dev Technol 18(8):356\u2013368","journal-title":"Assay Drug Dev Technol"},{"issue":"10","key":"2065_CR193","doi-asserted-by":"publisher","first-page":"e14280","DOI":"10.1111\/ijcp.14280","volume":"75","author":"F Pourhabibi-Zarandi","year":"2021","unstructured":"Pourhabibi-Zarandi F, Shojaei-Zarghani S, Rafraf M (2021) Curcumin and rheumatoid arthritis: a systematic review of literature. Int J Clin Pract 75(10):e14280","journal-title":"Int J Clin Pract"},{"issue":"9","key":"2065_CR194","doi-asserted-by":"publisher","first-page":"1410","DOI":"10.3390\/ijms17091410","volume":"17","author":"J Pu","year":"2016","unstructured":"Pu J, Fang F-F, Li X-Q, Shu Z-H, Jiang Y-P, Han T et al (2016) Matrine exerts a strong anti-arthritic effect on type II collagen-induced arthritis in rats by inhibiting inflammatory responses. Int J Mol Sci 17(9):1410","journal-title":"Int J Mol Sci"},{"key":"2065_CR195","doi-asserted-by":"publisher","first-page":"105985","DOI":"10.1016\/j.jddst.2024.105985","volume":"99","author":"M Rahmanian","year":"2024","unstructured":"Rahmanian M, Oroojalian F, Kesharwani P, Sahebkar A (2024) Current trends in triblock copolymer-based multifunctional nanotheranostics for cancer treatment. J Drug Deliv Sci Technol 99:105985. https:\/\/doi.org\/10.1016\/j.jddst.2024.105985","journal-title":"J Drug Deliv Sci Technol"},{"key":"2065_CR196","doi-asserted-by":"publisher","first-page":"103517","DOI":"10.1016\/j.jff.2019.103517","volume":"61","author":"M Raju","year":"2019","unstructured":"Raju M, Kulkarni YA, Wairkar S (2019) Therapeutic potential and recent delivery systems of berberine: a wonder molecule. J Funct Foods 61:103517. https:\/\/doi.org\/10.1016\/j.jff.2019.103517","journal-title":"J Funct Foods"},{"key":"2065_CR197","doi-asserted-by":"publisher","first-page":"113760","DOI":"10.1016\/j.biopha.2022.113760","volume":"155","author":"S Rampogu","year":"2022","unstructured":"Rampogu S, Balasubramaniyam T, Lee J-H (2022) Phytotherapeutic applications of alkaloids in treating breast cancer. Biomed Pharmacother 155:113760. https:\/\/doi.org\/10.1016\/j.biopha.2022.113760","journal-title":"Biomed Pharmacother"},{"issue":"sup1","key":"2065_CR198","doi-asserted-by":"publisher","first-page":"597","DOI":"10.1080\/21691401.2018.1431653","volume":"46","author":"K Rao","year":"2018","unstructured":"Rao K, Aziz S, Roome T, Razzak A, Sikandar B, Jamali KS et al (2018) Gum acacia stabilized silver nanoparticles based nano-cargo for enhanced anti-arthritic potentials of hesperidin in adjuvant induced arthritic rats. Artif Cells Nanomed Biotechnol 46(sup1):597\u2013607","journal-title":"Artif Cells Nanomed Biotechnol"},{"issue":"10","key":"2065_CR199","doi-asserted-by":"publisher","first-page":"977","DOI":"10.1056\/NEJMoa073003","volume":"357","author":"EF Remmers","year":"2007","unstructured":"Remmers EF, Plenge RM, Lee AT, Graham RR, Hom G, Behrens TW et al (2007) STAT4 and the risk of rheumatoid arthritis and systemic lupus erythematosus. N Engl J Med 357(10):977\u2013986","journal-title":"N Engl J Med"},{"key":"2065_CR200","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1016\/j.canlet.2021.05.001","volume":"515","author":"B Ren","year":"2021","unstructured":"Ren B, Kwah MX-Y, Liu C, Ma Z, Shanmugam MK, Ding L et al (2021) Resveratrol for cancer therapy: challenges and future perspectives. Cancer Lett 515:63\u201372","journal-title":"Cancer Lett"},{"issue":"2","key":"2065_CR201","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1016\/j.arcmed.2020.01.010","volume":"51","author":"G Repossi","year":"2020","unstructured":"Repossi G, Das UN, Eynard AR (2020) Molecular basis of the beneficial actions of resveratrol. Arch Med Res 51(2):105\u2013114","journal-title":"Arch Med Res"},{"issue":"11","key":"2065_CR202","doi-asserted-by":"publisher","first-page":"3400","DOI":"10.3390\/molecules27113400","volume":"27","author":"A Rojas-Gonz\u00e1lez","year":"2022","unstructured":"Rojas-Gonz\u00e1lez A, Figueroa-Hern\u00e1ndez CY, Gonz\u00e1lez-Rios O, Su\u00e1rez-Quiroz ML, Gonz\u00e1lez-Amaro RM, Hern\u00e1ndez-Estrada ZJ et al (2022) Coffee chlorogenic acids incorporation for bioactivity enhancement of foods: a review. Molecules 27(11):3400","journal-title":"Molecules"},{"issue":"9","key":"2065_CR203","doi-asserted-by":"publisher","first-page":"839","DOI":"10.1016\/j.joca.2006.04.008","volume":"14","author":"JA Roman-Blas","year":"2006","unstructured":"Roman-Blas JA, Jimenez SA (2006) NF-\u03baB as a potential therapeutic target in osteoarthritis and rheumatoid arthritis. Osteoarthr Cartilage 14(9):839\u2013848. https:\/\/doi.org\/10.1016\/j.joca.2006.04.008","journal-title":"Osteoarthr Cartilage"},{"issue":"2","key":"2065_CR204","doi-asserted-by":"publisher","first-page":"248","DOI":"10.1097\/BOR.0b013e32835c7e32","volume":"25","author":"L R\u00f6nnblom","year":"2013","unstructured":"R\u00f6nnblom L, Eloranta M-L (2013) The interferon signature in autoimmune diseases. Curr Opin Rheumatol 25(2):248\u2013253","journal-title":"Curr Opin Rheumatol"},{"issue":"1","key":"2065_CR205","doi-asserted-by":"publisher","first-page":"8656","DOI":"10.1038\/s41598-023-35161-0","volume":"13","author":"M Rudrapal","year":"2023","unstructured":"Rudrapal M, Eltayeb WA, Rakshit G, El-Arabey AA, Khan J, Aldosari SM et al (2023) Dual synergistic inhibition of COX and LOX by potential chemicals from Indian daily spices investigated through detailed computational studies. Sci Rep 13(1):8656","journal-title":"Sci Rep"},{"issue":"5","key":"2065_CR206","doi-asserted-by":"publisher","first-page":"e14011","DOI":"10.1111\/jfbc.14011","volume":"46","author":"Z Rui","year":"2022","unstructured":"Rui Z, Zhang L, Li X, Han J, Yuan Y, Ding H et al (2022) Pterostilbene exert an anti-arthritic effect by attenuating inflammation, oxidative stress, and alteration of gut microbiota. J Food Biochem 46(5):e14011. https:\/\/doi.org\/10.1111\/jfbc.14011","journal-title":"J Food Biochem"},{"key":"2065_CR207","doi-asserted-by":"publisher","first-page":"102322","DOI":"10.1016\/j.ctim.2020.102322","volume":"49","author":"M Saberi-Karimian","year":"2020","unstructured":"Saberi-Karimian M, Keshvari M, Ghayour-Mobarhan M, Salehizadeh L, Rahmani S, Behnam B et al (2020) Effects of curcuminoids on inflammatory status in patients with non-alcoholic fatty liver disease: a randomized controlled trial (Article). Complement Ther Med 49:102322. https:\/\/doi.org\/10.1016\/j.ctim.2020.102322","journal-title":"Complement Ther Med"},{"issue":"5","key":"2065_CR208","doi-asserted-by":"publisher","first-page":"e75","DOI":"10.1016\/j.fertnstert.2010.07.1071","volume":"94","author":"A Sahebkar","year":"2010","unstructured":"Sahebkar A (2010) Molecular mechanisms for curcumin benefits against ischemic injury (letter). Fertil Steril 94(5):e75\u2013e76. https:\/\/doi.org\/10.1016\/j.fertnstert.2010.07.1071","journal-title":"Fertil Steril"},{"issue":"12","key":"2065_CR209","doi-asserted-by":"publisher","first-page":"822","DOI":"10.1111\/nure.12081","volume":"71","author":"A Sahebkar","year":"2013","unstructured":"Sahebkar A (2013a) Effects of resveratrol supplementation on plasma lipids: a systematic review and meta-analysis of randomized controlled trials. Nutr Rev 71(12):822\u2013835. https:\/\/doi.org\/10.1111\/nure.12081","journal-title":"Nutr Rev"},{"issue":"2","key":"2065_CR210","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1002\/biof.1062","volume":"39","author":"A Sahebkar","year":"2013","unstructured":"Sahebkar A (2013b) Why it is necessary to translate curcumin into clinical practice for the prevention and treatment of metabolic syndrome? (review). BioFactors 39(2):197\u2013208. https:\/\/doi.org\/10.1002\/biof.1062","journal-title":"BioFactors"},{"issue":"2","key":"2065_CR211","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1038\/nrcardio.2013.140-c1","volume":"11","author":"A Sahebkar","year":"2014","unstructured":"Sahebkar A (2014) Curcuminoids for the management of hypertriglyceridaemia (letter). Nat Rev Cardiol 11(2):123. https:\/\/doi.org\/10.1038\/nrcardio.2013.140-c1","journal-title":"Nat Rev Cardiol"},{"issue":"6","key":"2065_CR212","doi-asserted-by":"publisher","first-page":"1192","DOI":"10.1093\/pm\/pnv024","volume":"17","author":"A Sahebkar","year":"2016","unstructured":"Sahebkar A, Henrotin Y (2016) Analgesic efficacy and safety of curcuminoids in clinical practice: a systematic review and meta-analysis of randomized controlled trials (review). Pain Med (United States) 17(6):1192\u20131202. https:\/\/doi.org\/10.1093\/pm\/pnv024","journal-title":"Pain Med (United States)"},{"issue":"12","key":"2065_CR213","doi-asserted-by":"publisher","first-page":"1883","DOI":"10.1002\/ptr.4952","volume":"27","author":"A Sahebkar","year":"2013","unstructured":"Sahebkar A, Mohammadi A, Atabati A, Rahiman S, Tavallaie S, Iranshahi M et al (2013) Curcuminoids modulate pro-oxidant-antioxidant balance but not the immune response to heat shock protein 27 and oxidized LDL in obese individuals (Article). Phytother Res 27(12):1883\u20131888. https:\/\/doi.org\/10.1002\/ptr.4952","journal-title":"Phytother Res"},{"key":"2065_CR214","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1016\/j.ijcard.2015.04.008","volume":"189","author":"A Sahebkar","year":"2015","unstructured":"Sahebkar A, Serban C, Ursoniu S, Wong ND, Muntner P, Graham IM et al (2015) Lack of efficacy of resveratrol on C-reactive protein and selected cardiovascular risk factors\u2013results from a systematic review and meta-analysis of randomized controlled trials. Int J Cardiol 189:47\u201355. https:\/\/doi.org\/10.1016\/j.ijcard.2015.04.008","journal-title":"Int J Cardiol"},{"issue":"10","key":"2065_CR215","doi-asserted-by":"publisher","first-page":"819","DOI":"10.2217\/nnm-2020-0316","volume":"16","author":"E Sana","year":"2021","unstructured":"Sana E, Zeeshan M, Ain QU, Khan AU, Hussain I, Khan S et al (2021) Topical delivery of curcumin-loaded transfersomes gel ameliorated rheumatoid arthritis by inhibiting NF-\u03ba\u03b2 pathway. Nanomedicine 16(10):819\u2013837","journal-title":"Nanomedicine"},{"key":"2065_CR216","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s40816-021-00291-3","volume":"7","author":"L\u00c2M Santiago","year":"2021","unstructured":"Santiago L\u00c2M, Neto RNM, Santos Ata\u00edde AC, Fonseca DCSC, Soares EFA, de S\u00e1 Sousa JC et al (2021) Flavonoids, alkaloids and saponins: are these plant-derived compounds an alternative to the treatment of rheumatoid arthritis? A literature review. Clin Phytosci 7:1\u201310","journal-title":"Clin Phytosci"},{"key":"2065_CR217","doi-asserted-by":"publisher","first-page":"135152","DOI":"10.1016\/j.ijbiomac.2024.135152","volume":"279","author":"S Sasan","year":"2024","unstructured":"Sasan S, Molavi AM, Moqadam KH, Farrokhi N, Oroojalian F (2024) Enhanced wound healing properties of biodegradable PCL\/alginate core-shell nanofibers containing Salvia abrotanoides essential oil and ZnO nanoparticles. Int J Biol Macromol 279:135152","journal-title":"Int J Biol Macromol"},{"issue":"12","key":"2065_CR218","doi-asserted-by":"publisher","first-page":"2569","DOI":"10.1084\/jem.20131241","volume":"210","author":"SW Scally","year":"2013","unstructured":"Scally SW, Petersen J, Law SC, Dudek NL, Nel HJ, Loh KL et al (2013) A molecular basis for the association of the HLA-DRB1 locus, citrullination, and rheumatoid arthritis. J Exp Med 210(12):2569\u20132582","journal-title":"J Exp Med"},{"key":"2065_CR219","doi-asserted-by":"publisher","first-page":"104353","DOI":"10.1016\/j.phrs.2019.104353","volume":"147","author":"R Shafabakhsh","year":"2019","unstructured":"Shafabakhsh R, Pourhanifeh MH, Mirzaei HR, Sahebkar A, Asemi Z, Mirzaei H (2019) Targeting regulatory T cells by curcumin: a potential for cancer immunotherapy (review). Pharmacol Res 147:104353. https:\/\/doi.org\/10.1016\/j.phrs.2019.104353","journal-title":"Pharmacol Res"},{"key":"2065_CR220","doi-asserted-by":"publisher","first-page":"330","DOI":"10.1016\/j.jad.2017.11.020","volume":"227","author":"M Shafiee","year":"2018","unstructured":"Shafiee M, Arekhi S, Omranzadeh A, Sahebkar A (2018) Saffron in the treatment of depression, anxiety and other mental disorders: current evidence and potential mechanisms of action (review). J Affect Disord 227:330\u2013337. https:\/\/doi.org\/10.1016\/j.jad.2017.11.020","journal-title":"J Affect Disord"},{"key":"2065_CR221","doi-asserted-by":"publisher","unstructured":"Shankar GM, Antony J, Anto RJ (2015) Chapter Two\u2014Quercetin and Tryptanthrin: two broad spectrum anticancer agents for future chemotherapeutic interventions. In S. Z. Bathaie, & F. Tamanoi (Eds.), The Enzymes (pp. 43\u201372). Academic Press. https:\/\/doi.org\/10.1016\/bs.enz.2015.05.001","DOI":"10.1016\/bs.enz.2015.05.001"},{"issue":"5","key":"2065_CR222","doi-asserted-by":"publisher","first-page":"765","DOI":"10.1111\/jphp.13058","volume":"71","author":"H Shen","year":"2019","unstructured":"Shen H, Liu Y, Zhang H, Ding P, Zhang L, Zhang L et al (2019) Enhancing the oral bioavailability of baicalein via Solutol\u00ae HS15 and Poloxamer 188 mixed micelles system. J Pharm Pharmacol 71(5):765\u2013773","journal-title":"J Pharm Pharmacol"},{"key":"2065_CR223","doi-asserted-by":"publisher","first-page":"829677","DOI":"10.3389\/fphar.2022.829677","volume":"13","author":"S Sheng","year":"2022","unstructured":"Sheng S, Wang X, Liu X, Hu X, Shao Y, Wang G et al (2022) The role of resveratrol on rheumatoid arthritis: from bench to bedside. Front Pharmacol 13:829677","journal-title":"Front Pharmacol"},{"key":"2065_CR224","doi-asserted-by":"publisher","first-page":"558741","DOI":"10.3389\/fphar.2020.558741","volume":"11","author":"J Shi","year":"2020","unstructured":"Shi J, Li J, Xu Z, Chen L, Luo R, Zhang C et al (2020) Celastrol: a review of useful strategies overcoming its limitation in anticancer application. Front Pharmacol 11:558741","journal-title":"Front Pharmacol"},{"issue":"7-8","key":"2065_CR225","doi-asserted-by":"publisher","first-page":"733","DOI":"10.1016\/j.nut.2008.03.013","volume":"24","author":"M Shukla","year":"2008","unstructured":"Shukla M, Gupta K, Rasheed Z, Khan KA, Haqqi TM (2008) Consumption of hydrolyzable tannins-rich pomegranate extract suppresses inflammation and joint damage in rheumatoid arthritis. Nutrition 24(7\u20138):733\u2013743. https:\/\/doi.org\/10.1016\/j.nut.2008.03.013","journal-title":"Nutrition"},{"key":"2065_CR226","doi-asserted-by":"crossref","unstructured":"Shukla R, Pandey V, Vadnere GP, Lodhi S (2019) Role of flavonoids in management of inflammatory disorders. Bioactive food as dietary interventions for arthritis and related inflammatory diseases (pp. 293\u2013322). Elsevier","DOI":"10.1016\/B978-0-12-813820-5.00018-0"},{"issue":"1","key":"2065_CR227","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s12668-024-01637-0","volume":"15","author":"V Shukla","year":"2025","unstructured":"Shukla V, Purohit A (2025) Berberine-loaded nanoparticles combat oxidative and nitrosative stress to reprogram macrophages in rheumatoid arthritis. BioNanoScience 15(1):1\u201320","journal-title":"BioNanoScience"},{"key":"2065_CR228","doi-asserted-by":"publisher","unstructured":"Sikora B, Bahadori B, Magg AD, Moghadasian N, Moghadasian MH (2025) Berberine: a bitter phytochemical with diversely sweet therapeutic properties. Nutr Rev, nuaf172. https:\/\/doi.org\/10.1093\/nutrit\/nuaf172","DOI":"10.1093\/nutrit\/nuaf172"},{"issue":"25","key":"2065_CR229","doi-asserted-by":"publisher","first-page":"907","DOI":"10.1016\/j.lfs.2010.04.013","volume":"86","author":"R Singh","year":"2010","unstructured":"Singh R, Akhtar N, Haqqi TM (2010) Green tea polyphenol epigallocatechi3-gallate: inflammation and arthritis. Life Sci 86(25):907\u2013918. https:\/\/doi.org\/10.1016\/j.lfs.2010.04.013","journal-title":"Life Sci"},{"issue":"2","key":"2065_CR230","doi-asserted-by":"publisher","first-page":"136","DOI":"10.1016\/j.bbcan.2013.12.005","volume":"1845","author":"KS Siveen","year":"2014","unstructured":"Siveen KS, Sikka S, Surana R, Dai X, Zhang J, Kumar AP et al (2014) Targeting the STAT3 signaling pathway in cancer: role of synthetic and natural inhibitors. Biochim Biophys Acta (BBA) Rev Cancer 1845(2):136\u2013154. https:\/\/doi.org\/10.1016\/j.bbcan.2013.12.005","journal-title":"Biochim Biophys Acta (BBA) Rev Cancer"},{"issue":"6","key":"2065_CR231","doi-asserted-by":"publisher","first-page":"rabab067","DOI":"10.1093\/rb\/rbab067","volume":"8","author":"C Song","year":"2021","unstructured":"Song C, Xu S, Chang L, Zhao X, Mei X, Ren X et al (2021) Preparation of EGCG decorated, injectable extracellular vesicles for cartilage repair in rat arthritis. Regen Biomater 8(6):rabab067","journal-title":"Regen Biomater"},{"issue":"6","key":"2065_CR232","first-page":"2303","volume":"21","author":"X Song","year":"2020","unstructured":"Song X, Zhang Y, Dai E (2020) Therapeutic targets of thunder god vine (Tripterygium wilfordii hook) in rheumatoid arthritis. Mol Med Rep 21(6):2303\u20132310","journal-title":"Mol Med Rep"},{"issue":"9","key":"2065_CR233","doi-asserted-by":"publisher","first-page":"e76229","DOI":"10.34119\/bjhrv7n9-465","volume":"7","author":"A Soumia","year":"2024","unstructured":"Soumia A, Hamza B, Fatima L, Mabrouk SK, Houari H, Boumediene M et al (2024) Formulation and evaluation of anti-arthritic potential of ointment based on flavonoids and tannins of Aristolochia longa against induced arthritis model in Wistar rats. Braz J Health Rev 7(9):e76229\u2013e76229","journal-title":"Braz J Health Rev"},{"issue":"6","key":"2065_CR234","doi-asserted-by":"publisher","first-page":"1397","DOI":"10.3390\/molecules25061397","volume":"25","author":"SJ Stohs","year":"2020","unstructured":"Stohs SJ, Chen O, Ray SD, Ji J, Bucci LR, Preuss HG (2020) Highly bioavailable forms of curcumin and promising avenues for curcumin-based research and application: a review. Molecules 25(6):1397","journal-title":"Molecules"},{"key":"2065_CR235","doi-asserted-by":"publisher","first-page":"1137289","DOI":"10.3389\/fphar.2024.1137289","volume":"15","author":"Y Sun","year":"2024","unstructured":"Sun Y, Wang C, Li X, Lu J, Wang M (2024) Recent advances in drug delivery of celastrol for enhancing efficiency and reducing the toxicity. Front Pharmacol 15:1137289","journal-title":"Front Pharmacol"},{"issue":"9","key":"2065_CR236","doi-asserted-by":"publisher","first-page":"1252","DOI":"10.1136\/ard.2004.032219","volume":"64","author":"E Suresh","year":"2005","unstructured":"Suresh E, Lambert CM (2005) Combination treatment strategies in early rheumatoid arthritis. Ann Rheum Dis 64(9):1252\u20131256","journal-title":"Ann Rheum Dis"},{"issue":"23","key":"2065_CR237","doi-asserted-by":"publisher","first-page":"7109","DOI":"10.3390\/molecules26237109","volume":"26","author":"P Tagde","year":"2021","unstructured":"Tagde P, Tagde P, Islam F, Tagde S, Shah M, Hussain ZD et al (2021) The multifaceted role of curcumin in advanced nanocurcumin form in the treatment and management of chronic disorders. Molecules 26(23):7109","journal-title":"Molecules"},{"key":"2065_CR238","doi-asserted-by":"publisher","first-page":"1989","DOI":"10.3389\/fimmu.2019.01989","volume":"10","author":"Y Takeuchi","year":"2019","unstructured":"Takeuchi Y, Hirota K, Sakaguchi S (2019) Synovial tissue inflammation mediated by autoimmune T cells. Front Immunol 10:1989","journal-title":"Front Immunol"},{"issue":"10","key":"2065_CR239","doi-asserted-by":"publisher","first-page":"1561","DOI":"10.1002\/mnfr.201000545","volume":"55","author":"T Takimoto","year":"2011","unstructured":"Takimoto T, Suzuki K, Arisaka H, Murata T, Ozaki H, Koyama N (2011) Effect of N-(p-coumaroyl) serotonin and N-feruloylserotonin, major anti-atherogenic polyphenols in safflower seed, on vasodilation, proliferation and migration of vascular smooth muscle cells. Mol Nutr Food Res 55(10):1561\u20131571","journal-title":"Mol Nutr Food Res"},{"issue":"4","key":"2065_CR240","first-page":"528","volume":"31","author":"L Tang","year":"2006","unstructured":"Tang L, Gao J, Chen X, Xie X (2006) Inhibitory effect of resveratrol on the proliferation of synoviocytes in rheumatoid arthritis and its mechanism in vitro. Zhong Nan Da Xue Xue Bao Yi Xue Ban= J Central South Univ Med Sci 31(4):528\u2013533","journal-title":"Zhong Nan Da Xue Xue Bao Yi Xue Ban= J Central South Univ Med Sci"},{"key":"2065_CR241","doi-asserted-by":"crossref","unstructured":"Tang M, Zeng Y, Peng W, Xie X, Yang Y, Ji B et al (2023) Pharmacological aspects of natural quercetin in rheumatoid arthritis. Drug Des Dev Therapy, 2043\u20132053","DOI":"10.2147\/DDDT.S364759"},{"key":"2065_CR242","doi-asserted-by":"publisher","first-page":"1829","DOI":"10.1007\/s00296-012-2657-0","volume":"33","author":"J Tian","year":"2013","unstructured":"Tian J, Chen J-W, Gao J-S, Li L, Xie X (2013) Resveratrol inhibits TNF-\u03b1-induced IL-1\u03b2, MMP-3 production in human rheumatoid arthritis fibroblast-like synoviocytes via modulation of PI3kinase\/Akt pathway. Rheumatol Int 33:1829\u20131835","journal-title":"Rheumatol Int"},{"issue":"4","key":"2065_CR243","doi-asserted-by":"publisher","first-page":"298","DOI":"10.13189\/app.2024.120403","volume":"12","author":"A Tiwari","year":"2024","unstructured":"Tiwari A, Patel K, Samal PK (2024) Oral bioefficacy enhancement of capsaicin for the effective treatment of rheumatoid arthritis. Adv Pharmacol Pharm 12(4):298\u2013312","journal-title":"Adv Pharmacol Pharm"},{"issue":"1","key":"2065_CR244","doi-asserted-by":"publisher","first-page":"3241","DOI":"10.1038\/s41598-018-21674-6","volume":"8","author":"WW Tong","year":"2018","unstructured":"Tong WW, Zhang C, Hong T, Liu DH, Wang C, Li J et al (2018) Silibinin alleviates inflammation and induces apoptosis in human rheumatoid arthritis fibroblast-like synoviocytes and has a therapeutic effect on arthritis in rats. Sci Rep 8(1):3241. https:\/\/doi.org\/10.1038\/s41598-018-21674-6","journal-title":"Sci Rep"},{"issue":"1","key":"2065_CR245","first-page":"4787643","volume":"2022","author":"M Torequl Islam","year":"2022","unstructured":"Torequl Islam M, Quispe C, Herrera-Bravo J, Rahaman MM, Hossain R, Sarkar C et al (2022) Activities and molecular mechanisms of diterpenes, diterpenoids, and their derivatives in rheumatoid arthritis. Evid-Based Complement Altern Med 2022(1):4787643","journal-title":"Evid-Based Complement Altern Med"},{"issue":"10","key":"2065_CR246","doi-asserted-by":"publisher","first-page":"e0223246","DOI":"10.1371\/journal.pone.0223246","volume":"14","author":"M Traylor","year":"2019","unstructured":"Traylor M, Knevel R, Cui J, Taylor J, Harm-Jan W, Conaghan PG et al (2019) Genetic associations with radiological damage in rheumatoid arthritis: meta-analysis of seven genome-wide association studies of 2775 cases. PLoS ONE 14(10):e0223246","journal-title":"PLoS ONE"},{"issue":"8","key":"2065_CR247","doi-asserted-by":"publisher","first-page":"472","DOI":"10.1038\/nrrheum.2016.91","volume":"12","author":"IA Udalova","year":"2016","unstructured":"Udalova IA, Mantovani A, Feldmann M (2016) Macrophage heterogeneity in the context of rheumatoid arthritis. Nat Rev Rheumatol 12(8):472\u2013485","journal-title":"Nat Rev Rheumatol"},{"issue":"3","key":"2065_CR248","doi-asserted-by":"publisher","first-page":"657","DOI":"10.1007\/s00296-012-2430-4","volume":"33","author":"S Umar","year":"2013","unstructured":"Umar S, Kumar A, Sajad M, Zargan J, Ansari MM, Ahmad S et al (2013) Hesperidin inhibits collagen-induced arthritis possibly through suppression of free radical load and reduction in neutrophil activation and infiltration. Rheumatol Int 33(3):657\u2013663. https:\/\/doi.org\/10.1007\/s00296-012-2430-4","journal-title":"Rheumatol Int"},{"issue":"2","key":"2065_CR249","doi-asserted-by":"publisher","first-page":"256","DOI":"10.3390\/nu14020256","volume":"14","author":"A Vahedian-Azimi","year":"2022","unstructured":"Vahedian-Azimi A, Abbasifard M, Rahimi-Bashar F, Guest PC, Majeed M, Mohammadi A et al (2022) Effectiveness of curcumin on outcomes of hospitalized COVID-19 patients: a systematic review of clinical trials (review). Nutrients 14(2):256. https:\/\/doi.org\/10.3390\/nu14020256","journal-title":"Nutrients"},{"issue":"1","key":"2065_CR250","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1136\/ard.2003.020347","volume":"64","author":"J van Holten","year":"2005","unstructured":"van Holten J, Pavelka K, Vencovsky J, Stahl H, Rozman B, Genovese M et al (2005) A multicentre, randomised, double blind, placebo controlled phase II study of subcutaneous interferon beta-1a in the treatment of patients with active rheumatoid arthritis. Ann Rheum Dis 64(1):64\u201369","journal-title":"Ann Rheum Dis"},{"issue":"4","key":"2065_CR251","doi-asserted-by":"publisher","first-page":"675","DOI":"10.1016\/j.molimm.2013.05.002","volume":"56","author":"A van Nieuwenhuijze","year":"2013","unstructured":"van Nieuwenhuijze A, Koenders M, Roeleveld D, Sleeman MA, van den Berg W, Wicks IP (2013) GM-CSF as a therapeutic target in inflammatory diseases. Mol Immunol 56(4):675\u2013682","journal-title":"Mol Immunol"},{"issue":"3","key":"2065_CR252","doi-asserted-by":"publisher","first-page":"180","DOI":"10.1038\/s41584-019-0170-5","volume":"15","author":"R van Vollenhoven","year":"2019","unstructured":"van Vollenhoven R (2019) Treat-to-target in rheumatoid arthritis\u2014are we there yet? Nat Rev Rheumatol 15(3):180\u2013186","journal-title":"Nat Rev Rheumatol"},{"issue":"16","key":"2065_CR253","doi-asserted-by":"publisher","first-page":"1645","DOI":"10.1001\/jama.2015.3435","volume":"313","author":"S Viatte","year":"2015","unstructured":"Viatte S, Plant D, Han B, Fu B, Yarwood A, Thomson W et al (2015) Association of HLA-DRB1 haplotypes with rheumatoid arthritis severity, mortality, and treatment response. JAMA 313(16):1645\u20131656","journal-title":"JAMA"},{"key":"2065_CR254","doi-asserted-by":"publisher","first-page":"102556","DOI":"10.1016\/j.fbio.2023.102556","volume":"53","author":"JdS Vieira","year":"2023","unstructured":"Vieira JdS, de Oliveira VS, Carneiro MJ, da Silva TL, Augusta IM, de Carvalho MG et al (2023) Phenolic composition and insights into the use of pink pepper (Schinus terebentifolius Raddi) fruit against lipid oxidation in food systems. Food Biosci 53:102556. https:\/\/doi.org\/10.1016\/j.fbio.2023.102556","journal-title":"Food Biosci"},{"key":"2065_CR255","doi-asserted-by":"publisher","first-page":"103160","DOI":"10.1016\/j.cis.2024.103160","volume":"327","author":"M Vishwakarma","year":"2024","unstructured":"Vishwakarma M, Agrawal P, Soni S, Tomar S, Haider T, Kashaw SK et al (2024) Cationic nanocarriers: a potential approach for targeting negatively charged cancer cell. Adv Colloid Interface Sci 327:103160. https:\/\/doi.org\/10.1016\/j.cis.2024.103160","journal-title":"Adv Colloid Interface Sci"},{"issue":"13","key":"2065_CR256","doi-asserted-by":"publisher","first-page":"3335","DOI":"10.1039\/D3BM02129G","volume":"12","author":"A Vyawahare","year":"2024","unstructured":"Vyawahare A, Jori C, Kumar J, Fareed M, Ali N, Parida K et al (2024) A chlorogenic acid-conjugated nanomicelle attenuates disease severity in experimental arthritis. Biomater Sci 12(13):3335\u20133344","journal-title":"Biomater Sci"},{"issue":"11","key":"2065_CR257","doi-asserted-by":"publisher","first-page":"18579","DOI":"10.1021\/acsnano.2c07027","volume":"16","author":"A Vyawahare","year":"2022","unstructured":"Vyawahare A, Prakash R, Jori C, Ali A, Raza SS, Khan R (2022) Caffeic acid modified nanomicelles inhibit articular cartilage deterioration and reduce disease severity in experimental inflammatory arthritis. ACS Nano 16(11):18579\u201318591","journal-title":"ACS Nano"},{"issue":"1","key":"2065_CR258","doi-asserted-by":"publisher","first-page":"38","DOI":"10.3390\/biochem4010003","volume":"4","author":"H Wahnou","year":"2024","unstructured":"Wahnou H, Limami Y, Oudghiri M (2024) Flavonoids and flavonoid-based nanoparticles for osteoarthritis and rheumatoid arthritis management. BioChem 4(1):38\u201361","journal-title":"BioChem"},{"key":"2065_CR259","doi-asserted-by":"publisher","first-page":"106311","DOI":"10.1016\/j.fitote.2024.106311","volume":"180","author":"HF Wang","year":"2025","unstructured":"Wang HF, Huang ZH, Zou W, Lai CH, Tan QG (2025) Tracheloside, the main constituent of the total lignan extract from TrachelospermiCaulis, inhibited rheumatoid arthritis via IL-17\/MAPK signaling pathway. Fitoterapia 180:106311. https:\/\/doi.org\/10.1016\/j.fitote.2024.106311","journal-title":"Fitoterapia"},{"key":"2065_CR260","doi-asserted-by":"publisher","first-page":"114464","DOI":"10.1016\/j.biopha.2023.114464","volume":"162","author":"J Wang","year":"2023","unstructured":"Wang J, Liu Y-M, Hu J, Chen C (2023) Potential of natural products in combination with arsenic trioxide: investigating cardioprotective effects and mechanisms. Biomed Pharmacother 162:114464. https:\/\/doi.org\/10.1016\/j.biopha.2023.114464","journal-title":"Biomed Pharmacother"},{"issue":"2","key":"2065_CR261","doi-asserted-by":"publisher","first-page":"2151","DOI":"10.1002\/jcb.27523","volume":"120","author":"J Wang","year":"2019","unstructured":"Wang J, Zhao Q (2019) Betulinic acid inhibits cell proliferation, migration, and inflammatory response in rheumatoid arthritis fibroblast-like synoviocytes. J Cell Biochem 120(2):2151\u20132158","journal-title":"J Cell Biochem"},{"key":"2065_CR262","doi-asserted-by":"publisher","first-page":"155258","DOI":"10.1016\/j.phymed.2023.155258","volume":"128","author":"K Wang","year":"2024","unstructured":"Wang K, Yin J, Chen J, Ma J, Si H, Xia D (2024a) Inhibition of inflammation by berberine: molecular mechanism and network pharmacology analysis. Phytomedicine 128:155258. https:\/\/doi.org\/10.1016\/j.phymed.2023.155258","journal-title":"Phytomedicine"},{"issue":"9","key":"2065_CR263","doi-asserted-by":"publisher","first-page":"347","DOI":"10.1089\/jir.2021.0044","volume":"41","author":"L Wang","year":"2021","unstructured":"Wang L, Pan F, Luo T (2021) Sinapic acid attenuates rheumatoid arthritis through reducing inflammation and oxidative stress by downregulating I\u03baB kinase. J Interferon Cytokine Res 41(9):347\u2013354","journal-title":"J Interferon Cytokine Res"},{"key":"2065_CR264","doi-asserted-by":"publisher","unstructured":"Wang Y-J, Chen R-J (2014) Chapter 27\u2014Pterostilbene protection and bladder cancer cells. In: V. Preedy (Ed.), Cancer (pp. 271\u2013281). San Diego: Academic Press. https:\/\/doi.org\/10.1016\/B978-0-12-405205-5.00027-1","DOI":"10.1016\/B978-0-12-405205-5.00027-1"},{"issue":"21","key":"2065_CR265","doi-asserted-by":"publisher","first-page":"24673","DOI":"10.1021\/acsanm.4c04466","volume":"7","author":"Y Wang","year":"2024","unstructured":"Wang Y, Xu F, Wang Y, Hu X, Zhao B, Lin S et al (2024b) Prussian blue nanostructure conjugated berberine improves inflammatory response of rheumatoid arthritis by suppressing necroptosis. ACS Appl Nano Mater 7(21):24673\u201324682","journal-title":"ACS Appl Nano Mater"},{"issue":"1","key":"2065_CR266","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1080\/13880209.2018.1459740","volume":"56","author":"Z Wang","year":"2018","unstructured":"Wang Z, Chen D, Wang Z (2018) Effects of diclofenac on the pharmacokinetics of celastrol in rats and its transport. Pharm Biol 56(1):269\u2013274","journal-title":"Pharm Biol"},{"issue":"4","key":"2065_CR267","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1080\/08923973.2017.1327963","volume":"39","author":"H-l Wen","year":"2017","unstructured":"Wen H-l, Yang G, Dong Q-r (2017) Ellipticine inhibits the proliferation and induces apoptosis in rheumatoid arthritis fibroblast-like synoviocytes via the STAT3 pathway. Immunopharmacol Immunotoxicol 39(4):219\u2013224","journal-title":"Immunopharmacol Immunotoxicol"},{"key":"2065_CR268","doi-asserted-by":"publisher","first-page":"152111","DOI":"10.1016\/j.bbrc.2025.152111","volume":"775","author":"X Wu","year":"2025","unstructured":"Wu X, Teng K, He Y, Cai X, Zhu J, Han L et al (2025) Mechanistic insights into the anti-rheumatoid arthritis effects of ursolic acid from Periploca forrestii Schltr. via network pharmacology, molecular docking, and experimental validation. Biochem Biophys Res Commun 775:152111. https:\/\/doi.org\/10.1016\/j.bbrc.2025.152111","journal-title":"Biochem Biophys Res Commun"},{"issue":"5","key":"2065_CR269","doi-asserted-by":"publisher","first-page":"1127","DOI":"10.3390\/cells9051127","volume":"9","author":"T Wysocki","year":"2020","unstructured":"Wysocki T, Olesi\u0144ska M, Paradowska-Gorycka A (2020) Current understanding of an emerging role of HLA-DRB1 gene in rheumatoid arthritis\u2013from research to clinical practice. Cells 9(5):1127","journal-title":"Cells"},{"key":"2065_CR270","doi-asserted-by":"publisher","first-page":"153339","DOI":"10.1016\/j.phymed.2020.153339","volume":"80","author":"Y Xie","year":"2021","unstructured":"Xie Y, Feng S-L, Mai C-T, Zheng Y-F, Wang H, Liu Z-Q et al (2021) Suppression of up-regulated LXR\u03b1 by silybin ameliorates experimental rheumatoid arthritis and abnormal lipid metabolism. Phytomedicine 80:153339","journal-title":"Phytomedicine"},{"key":"2065_CR271","doi-asserted-by":"publisher","first-page":"110525","DOI":"10.1016\/j.biopha.2020.110525","volume":"130","author":"A Xu","year":"2020","unstructured":"Xu A, Deng F, Chen Y, Kong Y, Pan L, Liao Q et al (2020) NF-kappaB pathway activation during endothelial-to-mesenchymal transition in a rat model of doxorubicin-induced cardiotoxicity. Biomed Pharmacother 130:110525. https:\/\/doi.org\/10.1016\/j.biopha.2020.110525","journal-title":"Biomed Pharmacother"},{"issue":"1","key":"2065_CR272","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1136\/ard.2011.149831","volume":"71","author":"G Xuzhu","year":"2012","unstructured":"Xuzhu G, Komai-Koma M, Leung BP, Howe HS, McSharry C, McInnes IB et al (2012) Resveratrol modulates murine collagen-induced arthritis by inhibiting Th17 and B-cell function. Ann Rheum Dis 71(1):129\u2013135","journal-title":"Ann Rheum Dis"},{"key":"2065_CR273","doi-asserted-by":"publisher","DOI":"10.2147\/IJN.S219413","author":"F Yan","year":"2019","unstructured":"Yan F, Li H, Zhong Z, Zhou M, Lin Y, Tang C et al (2019) Co-delivery of prednisolone and curcumin in human serum albumin nanoparticles for effective treatment of rheumatoid arthritis. Int J Nanomed. https:\/\/doi.org\/10.2147\/IJN.S219413","journal-title":"Int J Nanomed"},{"issue":"2","key":"2065_CR274","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1016\/S0165-2478(02)00079-2","volume":"83","author":"J Youn","year":"2002","unstructured":"Youn J, Kim H-Y, Park JH, Hwang S-H, Lee SY, Cho C-S et al (2002) Regulation of TNF-\u03b1-mediated hyperplasia through TNF receptors, TRAFs, and NF-\u03baB in synoviocytes obtained from patients with rheumatoid arthritis. Immunol Lett 83(2):85\u201393","journal-title":"Immunol Lett"},{"key":"2065_CR275","doi-asserted-by":"crossref","unstructured":"Yu WeiGuang YW, Shen Yong SY, Wu Jian Zhong WJ, Gao YanBing GY, Zhang LiXing ZL (2018) Madecassoside impedes invasion of rheumatoid fibroblast-like synoviocyte from adjuvant arthritis rats via inhibition of NF-\u03baB-mediated matrix metalloproteinase-13 expression","DOI":"10.1016\/S1875-5364(18)30064-5"},{"issue":"5","key":"2065_CR276","doi-asserted-by":"publisher","first-page":"1865","DOI":"10.1021\/mp300649z","volume":"10","author":"H Yuan","year":"2013","unstructured":"Yuan H, Chen C-Y, Chai G-h, Du Y-Z, Hu F-Q (2013) Improved transport and absorption through gastrointestinal tract by PEGylated solid lipid nanoparticles. Mol Pharm 10(5):1865\u20131873","journal-title":"Mol Pharm"},{"key":"2065_CR277","doi-asserted-by":"publisher","first-page":"108454","DOI":"10.1016\/j.jnutbio.2020.108454","volume":"84","author":"K Yuan","year":"2020","unstructured":"Yuan K, Zhu Q, Lu Q, Jiang H, Zhu M, Li X et al (2020) Quercetin alleviates rheumatoid arthritis by inhibiting neutrophil inflammatory activities. J Nutr Biochem 84:108454. https:\/\/doi.org\/10.1016\/j.jnutbio.2020.108454","journal-title":"J Nutr Biochem"},{"key":"2065_CR278","doi-asserted-by":"publisher","first-page":"115419","DOI":"10.1016\/j.jep.2022.115419","volume":"298","author":"W Zeng","year":"2022","unstructured":"Zeng W, Cui H, Yang W, Zhao Z (2022) A systematic review: botany, phytochemistry, traditional uses, pharmacology, toxicology, quality control and pharmacokinetics of Ilex rotunda Thunb. J Ethnopharmacol 298:115419. https:\/\/doi.org\/10.1016\/j.jep.2022.115419","journal-title":"J Ethnopharmacol"},{"issue":"6","key":"2065_CR279","doi-asserted-by":"publisher","first-page":"816","DOI":"10.1016\/j.ajps.2021.09.001","volume":"16","author":"G Zhang","year":"2021","unstructured":"Zhang G, Sun G, Guan H, Li M, Liu Y, Tian B et al (2021) Naringenin nanocrystals for improving anti-rheumatoid arthritis activity. Asian J Pharm Sci 16(6):816\u2013825. https:\/\/doi.org\/10.1016\/j.ajps.2021.09.001","journal-title":"Asian J Pharm Sci"},{"issue":"1","key":"2065_CR280","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1016\/j.jep.2012.09.005","volume":"144","author":"J Zhang","year":"2012","unstructured":"Zhang J, Li C-Y, Xu M-J, Wu T, Chu J-H, Liu S-J et al (2012) Oral bioavailability and gender-related pharmacokinetics of celastrol following administration of pure celastrol and its related tablets in rats. J Ethnopharmacol 144(1):195\u2013200","journal-title":"J Ethnopharmacol"},{"issue":"02","key":"2065_CR281","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1142\/S0192415X16500130","volume":"44","author":"L-L Zhang","year":"2016","unstructured":"Zhang L-L, Tian K, Tang Z-H, Chen X-J, Bian Z-X, Wang Y-T et al (2016) Phytochemistry and pharmacology of Carthamus tinctorius L. Am J Chin Med 44(02):197\u2013226","journal-title":"Am J Chin Med"},{"issue":"1\u20132","key":"2065_CR282","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1016\/j.cell.2016.12.012","volume":"168","author":"Q Zhang","year":"2017","unstructured":"Zhang Q, Lenardo MJ, Baltimore D (2017) 30 years of NF-kappaB: a blossoming of relevance to human pathobiology. Cell 168(1\u20132):37\u201357. https:\/\/doi.org\/10.1016\/j.cell.2016.12.012","journal-title":"Cell"},{"key":"2065_CR283","doi-asserted-by":"publisher","first-page":"112951","DOI":"10.1016\/j.matdes.2024.112951","volume":"241","author":"W Zhang","year":"2024","unstructured":"Zhang W, Huang Y, Li J, Zhou M, Huang W, Sun L et al (2024) Carrier-free poly(glycyrrhetinic acid)-facilitated celastrol-loaded nanoparticle for high-efficiency low-toxicity treatment of rheumatoid arthritis. Mater des 241:112951. https:\/\/doi.org\/10.1016\/j.matdes.2024.112951","journal-title":"Mater des"},{"key":"2065_CR284","doi-asserted-by":"publisher","first-page":"113688","DOI":"10.1016\/j.inoche.2024.113688","volume":"172","author":"X Zhang","year":"2025","unstructured":"Zhang X, Diao Z, Amraii SA, Sillanp\u00e4\u00e4 M, Toushmalani R (2025) Formulation and evaluation of anti-rheumatoid arthritis effects of Ag nanoparticles containing Allium sativum L. leaf extract. Inorg Chem Commun 172:113688. https:\/\/doi.org\/10.1016\/j.inoche.2024.113688","journal-title":"Inorg Chem Commun"},{"issue":"44","key":"2065_CR285","doi-asserted-by":"publisher","first-page":"59789","DOI":"10.1021\/acsami.4c11494","volume":"16","author":"X Zhao","year":"2024","unstructured":"Zhao X, Wu S, Ni S, Zhong Y, Qin X, Zhang K et al (2024) Tannic acid-based biomimetic nanomedicine with pathological reactive oxygen species-responsive cargo release for relieving inflammation in rheumatoid arthritis. ACS Appl Mater Interfaces 16(44):59789\u201359802. https:\/\/doi.org\/10.1021\/acsami.4c11494","journal-title":"ACS Appl Mater Interfaces"},{"key":"2065_CR286","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1016\/j.intimp.2017.02.009","volume":"45","author":"W Zheng","year":"2017","unstructured":"Zheng W, Feng Z, You S, Zhang H, Tao Z, Wang Q et al (2017) Fisetin inhibits IL-1\u03b2-induced inflammatory response in human osteoarthritis chondrocytes through activating SIRT1 and attenuates the progression of osteoarthritis in mice. Int Immunopharmacol 45:135\u2013147","journal-title":"Int Immunopharmacol"},{"key":"2065_CR287","doi-asserted-by":"crossref","unstructured":"Zheng Z, Sun Y, Liu Z, Zhang M, Li C, Cai H (2015) The effect of curcumin and its nanoformulation on adjuvant-induced arthritis in rats. Drug Des Development Therapy, 4931\u20134942","DOI":"10.2147\/DDDT.S90147"},{"key":"2065_CR288","doi-asserted-by":"publisher","first-page":"116180","DOI":"10.1016\/j.biopha.2024.116180","volume":"171","author":"B Zhou","year":"2024","unstructured":"Zhou B, Chen D, Zhang T, Song C, Zhang X, Lin L et al (2024) Recent advancements in the discovery of small-molecule non-nucleoside inhibitors targeting SARS-CoV-2 RdRp. Biomed Pharmacother 171:116180","journal-title":"Biomed Pharmacother"},{"key":"2065_CR289","doi-asserted-by":"publisher","first-page":"114242","DOI":"10.1016\/j.biopha.2023.114242","volume":"159","author":"S Zhou","year":"2023","unstructured":"Zhou S, Lv P, Li M, Chen Z, Xin H, Reilly S et al (2023) SARS-CoV-2 E protein: pathogenesis and potential therapeutic development. Biomed Pharmacother 159:114242. https:\/\/doi.org\/10.1016\/j.biopha.2023.114242","journal-title":"Biomed Pharmacother"},{"key":"2065_CR290","doi-asserted-by":"publisher","first-page":"605616","DOI":"10.3389\/fimmu.2021.605616","volume":"12","author":"X Zhou","year":"2021","unstructured":"Zhou X, Xie D, Huang J, Lu A, Wang R, Jin Y et al (2021) Therapeutic effects of (5R)-5-hydroxytriptolide on fibroblast-like synoviocytes in rheumatoid arthritis via lncRNA WAKMAR2\/miR-4478\/E2F1\/p53 axis. Front Immunol 12:605616","journal-title":"Front Immunol"},{"key":"2065_CR291","doi-asserted-by":"publisher","first-page":"101358","DOI":"10.1016\/j.nantod.2021.101358","volume":"42","author":"Y Zhu","year":"2022","unstructured":"Zhu Y, Zhao T, Liu M, Wang S, Liu S, Yang Y et al (2022) Rheumatoid arthritis microenvironment insights into treatment effect of nanomaterials. Nano Today 42:101358","journal-title":"Nano Today"}],"container-title":["Inflammopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10787-025-02065-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10787-025-02065-6","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10787-025-02065-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,29]],"date-time":"2026-01-29T17:03:44Z","timestamp":1769706224000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10787-025-02065-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,8]]},"references-count":291,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["2065"],"URL":"https:\/\/doi.org\/10.1007\/s10787-025-02065-6","relation":{},"ISSN":["0925-4692","1568-5608"],"issn-type":[{"value":"0925-4692","type":"print"},{"value":"1568-5608","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12,8]]},"assertion":[{"value":"15 August 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 November 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 December 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}}]}}