{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T01:50:19Z","timestamp":1792461019803,"version":"4.5.0"},"reference-count":151,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2026,2,14]],"date-time":"2026-02-14T00:00:00Z","timestamp":1771027200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2026,2,14]],"date-time":"2026-02-14T00:00:00Z","timestamp":1771027200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100007082","name":"Universidade Federal De Santa Catarina","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100007082","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Inflammopharmacol"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Psoriasis is a chronic inflammatory skin disease characterized primarily by hyperproliferation of keratinocytes, infiltration and activation of immune cells, including T lymphocytes and macrophages, as well as increased innervation by sensory neurons. Although several therapeutic options are available, the management of psoriasis remains unsatisfactory, with adverse effects and unmet clinical needs. In this context, channels from the Transient Receptor Potential (TRP) family, which are non-selective cation channels involved in various pathologies, have been identified as potential therapeutic targets for treating psoriasis. Growing evidence suggests the involvement of multiple TRP subtypes in the pathogenesis of psoriasis, including altered expression of vanilloid subtypes, such as TRPV1, TRPV3, TRPV4, TRPV6, the canonical TRPC6, and melastatin TRPM8 in patients. These channels are involved in processes such as keratinocyte differentiation and proliferation, immune cell activation (e.g., T cells), and sensory neuron stimulation. Although there are still few studies on the role of TRPs in the therapies currently used for psoriasis, there is evidence of the activation of TRPV1 and the TRPA1 subtypes in the adverse effects of topical pharmacotherapy and phototherapy. On the other hand, TRPV1 desensitization (usually produced by repeated treatment with the TRPV1 agonist capsaicin) can reduce the severity of psoriasis and pruritus. Thus, the pharmacological modulation of TRP channels represents a promising strategy for developing novel, efficacious, and safer therapies to treat patients with psoriasis. This review aimed to provide a comprehensive overview of the involvement of TRP channels in the pathogenesis and therapeutic approaches to psoriasis.<\/jats:p>","DOI":"10.1007\/s10787-025-02095-0","type":"journal-article","created":{"date-parts":[[2026,2,14]],"date-time":"2026-02-14T15:26:59Z","timestamp":1771082819000},"page":"1361-1378","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Role of transient receptor potential channels on pathogenesis and treatment of psoriasis"],"prefix":"10.1007","volume":"34","author":[{"given":"Ana Merian","family":"da Silva","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Romina","family":"Nassini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"De Logu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9562-0602","authenticated-orcid":false,"given":"Juliano","family":"Ferreira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,2,14]]},"reference":[{"issue":"6","key":"2095_CR1","doi-asserted-by":"publisher","first-page":"752","DOI":"10.5114\/ada.2019.91425","volume":"36","author":"N Ab\u0119d\u017a","year":"2019","unstructured":"Ab\u0119d\u017a N, Pawliczak R (2019) Efficacy and safety of topical calcineurin inhibitors for the treatment of atopic dermatitis: meta-analysis of randomized clinical trials. Postepy Dermatol Alergol 36(6):752\u2013759. https:\/\/doi.org\/10.5114\/ada.2019.91425","journal-title":"Postepy Dermatol Alergol"},{"issue":"1","key":"2095_CR2","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1111\/bjd.14101","volume":"174","author":"D Al-Ismail","year":"2016","unstructured":"Al-Ismail D, Edwards C, Anstey AV (2016) Erythema action spectrum of topical 8-methoxypsoralen-sensitized skin re-evaluated: implications for routine clinical practice. Br J Dermatol 174(1):131\u2013135. https:\/\/doi.org\/10.1111\/bjd.14101","journal-title":"Br J Dermatol"},{"issue":"2","key":"2095_CR3","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1007\/s40257-013-0015-y","volume":"14","author":"F Almutawa","year":"2013","unstructured":"Almutawa F, Alnomair N, Wang Y, Hamzavi I, Lim HW (2013) Systematic review of UV-based therapy for psoriasis. Am J Clin Dermatol 14(2):87\u2013109. https:\/\/doi.org\/10.1007\/s40257-013-0015-y","journal-title":"Am J Clin Dermatol"},{"issue":"12","key":"2095_CR4","doi-asserted-by":"publisher","first-page":"2356","DOI":"10.1016\/j.jid.2023.05.009","volume":"143","author":"SN Amalia","year":"2023","unstructured":"Amalia SN, Baral H, Fujiwara C, Uchiyama A, Inoue Y, Yamazaki S, Ishikawa M, Kosaka K, Sekiguchi A, Yokoyama Y, Ogino S, Torii R, Hosoi M, Shibasaki K, Motegi SI (2023) TRPV4 regulates the development of psoriasis by controlling Adenosine Triphosphate expression in keratinocytes and the neuroimmune system. J Invest Dermatol 143(12):2356-2365.e5. https:\/\/doi.org\/10.1016\/j.jid.2023.05.009","journal-title":"J Invest Dermatol"},{"issue":"9","key":"2095_CR5","doi-asserted-by":"publisher","first-page":"1723","DOI":"10.1097\/j.pain.0000000000000979","volume":"158","author":"HH Andersen","year":"2017","unstructured":"Andersen HH, Lo Vecchio S, Gazerani P, Arendt-Nielsen L (2017) Dose-response study of topical allyl isothiocyanate (mustard oil) as a human surrogate model of pain, hyperalgesia, and neurogenic inflammation. Pain 158(9):1723\u20131732. https:\/\/doi.org\/10.1097\/j.pain.0000000000000979","journal-title":"Pain"},{"issue":"Suppl 3","key":"2095_CR6","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1111\/j.1468-3083.2012.04519.x","volume":"26","author":"E Archier","year":"2012","unstructured":"Archier E, Devaux S, Castela E, Gallini A, Aubin F, Le Ma\u00eetre M, Aractingi S, Bachelez H, Cribier B, Joly P, Jullien D, Misery L, Paul C, Ortonne JP, Richard MA (2012) Efficacy of psoralen UV-A therapy vs. narrowband UV-B therapy in chronic plaque psoriasis: a systematic literature review. J Eur Acad Dermatol Venereol 26(Suppl 3):11\u201321. https:\/\/doi.org\/10.1111\/j.1468-3083.2012.04519.x","journal-title":"J Eur Acad Dermatol Venereol"},{"issue":"19","key":"2095_CR7","doi-asserted-by":"publisher","first-page":"1945","DOI":"10.1001\/jama.2020.4006","volume":"323","author":"AW Armstrong","year":"2020","unstructured":"Armstrong AW, Read C (2020) Pathophysiology, clinical presentation, and treatment of psoriasis: a review. JAMA 323(19):1945\u20131960. https:\/\/doi.org\/10.1001\/jama.2020.4006","journal-title":"JAMA"},{"key":"2095_CR8","doi-asserted-by":"publisher","first-page":"107743","DOI":"10.1016\/j.pharmthera.2020.107743","volume":"220","author":"V Arora","year":"2021","unstructured":"Arora V, Campbell JN, Chung MK (2021) Fight fire with fire: neurobiology of capsaicin-induced analgesia for chronic pain. Pharmacol Ther 220:107743. https:\/\/doi.org\/10.1016\/j.pharmthera.2020.107743","journal-title":"Pharmacol Ther"},{"issue":"9","key":"2095_CR9","doi-asserted-by":"publisher","first-page":"2312","DOI":"10.1038\/jid.2009.58","volume":"129","author":"R Atoyan","year":"2009","unstructured":"Atoyan R, Shander D, Botchkareva NV (2009) Non-neuronal expression of transient receptor potential type A1 (TRPA1) in human skin. J Invest Dermatol 129(9):2312\u20132315. https:\/\/doi.org\/10.1038\/jid.2009.58","journal-title":"J Invest Dermatol"},{"issue":"19","key":"2095_CR10","doi-asserted-by":"publisher","first-page":"5264","DOI":"10.1523\/JNEUROSCI.4268-15.2016","volume":"36","author":"A Babes","year":"2016","unstructured":"Babes A, Sauer SK, Moparthi L, Kichko TI, Neacsu C, Namer B, Filipovic M, Zygmunt PM, Reeh PW, Fischer MJ (2016) Photosensitization in Porphyrias and photodynamic therapy involves TRPA1 and TRPV1. J Neurosci 36(19):5264\u20135278. https:\/\/doi.org\/10.1523\/JNEUROSCI.4268-15.2016","journal-title":"J Neurosci"},{"issue":"1","key":"2095_CR11","doi-asserted-by":"publisher","first-page":"122","DOI":"10.1002\/ejp.1654","volume":"25","author":"A Babes","year":"2021","unstructured":"Babes A, Kichko TI, Selescu T, Manolache A, Neacsu C, Gebhardt L, Reeh PW (2021) Psoralens activate and photosensitize Transient Receptor Potential channels Ankyrin type 1 (TRPA1) and Vanilloid type 1 (TRPV1). Eur J Pain 25(1):122\u2013135. https:\/\/doi.org\/10.1002\/ejp.1654","journal-title":"Eur J Pain"},{"issue":"25","key":"2095_CR12","doi-asserted-by":"publisher","first-page":"19362","DOI":"10.1074\/jbc.M109.087742","volume":"285","author":"S Bang","year":"2010","unstructured":"Bang S, Yoo S, Yang TJ, Cho H, Hwang SW (2010) Farnesyl pyrophosphate is a novel pain-producing molecule via specific activation of TRPV3. J Biol Chem 285(25):19362\u201319371. https:\/\/doi.org\/10.1074\/jbc.M109.087742","journal-title":"J Biol Chem"},{"key":"2095_CR13","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1016\/j.ceca.2017.05.012","volume":"66","author":"H Beckmann","year":"2017","unstructured":"Beckmann H, Richter J, Hill K, Urban N, Lemoine H, Schaefer M (2017) A benzothiadiazine derivative and methylprednisolone are novel and selective activators of transient receptor potential canonical 5 (TRPC5) channels. Cell Calcium 66:10\u201318. https:\/\/doi.org\/10.1016\/j.ceca.2017.05.012","journal-title":"Cell Calcium"},{"issue":"9","key":"2095_CR14","doi-asserted-by":"publisher","first-page":"e56991","DOI":"10.7554\/eLife.56991","volume":"2","author":"T Benezeder","year":"2020","unstructured":"Benezeder T, Painsi C, Patra V, Dey S, Holcmann M, Lange-Asschenfeldt B, Sibilia M, Wolf P (2020) Dithranol targets keratinocytes, their crosstalk with neutrophils, and inhibits the IL-36 inflammatory loop in psoriasis. Elife 2(9):e56991. https:\/\/doi.org\/10.7554\/eLife.56991","journal-title":"Elife"},{"issue":"9","key":"2095_CR15","doi-asserted-by":"publisher","first-page":"1655","DOI":"10.1113\/JP284262","volume":"601","author":"M Ben\u00edtez-Angeles","year":"2023","unstructured":"Ben\u00edtez-Angeles M, Romero AEL, Llorente I, Hern\u00e1ndez-Araiza I, Vergara-Jaque A, Real FH, Guti\u00e9rrez Casta\u00f1eda \u00d3E, Arciniega M, Morales-Buenrostro LE, Torres-Quiroz F, Garc\u00eda-Villegas R, Tovar-Y-Romo LB, Liedtke WB, Islas LD, Rosenbaum T (2023) Modes of action of lysophospholipids as endogenous activators of the TRPV4 ion channel. J Physiol 601(9):1655\u20131673. https:\/\/doi.org\/10.1113\/JP284262","journal-title":"J Physiol"},{"issue":"3","key":"2095_CR16","doi-asserted-by":"publisher","first-page":"504","DOI":"10.1016\/s0190-9622(86)70201-6","volume":"15","author":"JE Bernstein","year":"1986","unstructured":"Bernstein JE, Parish LC, Rapaport M, Rosenbaum MM, Roenigk HH Jr (1986) Effects of topically applied capsaicin on moderate and severe psoriasis vulgaris. J Am Acad Dermatol 15(3):504\u2013507. https:\/\/doi.org\/10.1016\/s0190-9622(86)70201-6","journal-title":"J Am Acad Dermatol"},{"issue":"26","key":"2095_CR17","doi-asserted-by":"publisher","first-page":"E3345","DOI":"10.1073\/pnas.1423357112","volume":"112","author":"G Bidaux","year":"2015","unstructured":"Bidaux G, Borowiec AS, Gordienko D, Beck B, Shapovalov GG, Lemonnier L, Flourakis M, Vandenberghe M, Slomianny C, Dewailly E, Delcourt P, Desruelles E, Ritaine A, Polakowska R, Lesage J, Chami M, Skryma R, Prevarskaya N (2015) Epidermal TRPM8 channel isoform controls the balance between keratinocyte proliferation and differentiation in a cold-dependent manner. Proc Natl Acad Sci U S A 112(26):E3345\u2013E3354. https:\/\/doi.org\/10.1073\/pnas.1423357112","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2095_CR18","doi-asserted-by":"publisher","unstructured":"Blair et al (2023) Transient receptor potential channels (TRP) in GtoPdb v.2023.3. IUPHAR\/BPS guide to pharmacology CITE, [S. l.],2023(3) https:\/\/doi.org\/10.2218\/gtopdb\/F78\/2023.3. https:\/\/journals.ed.ac.uk\/gtopdb-cite\/article\/view\/9420https:\/\/journals.ed.ac.uk\/gtopdb-cite\/article\/view\/9420","DOI":"10.2218\/gtopdb\/F78\/2023.3"},{"issue":"5","key":"2095_CR19","doi-asserted-by":"publisher","first-page":"636","DOI":"10.1016\/j.freeradbiomed.2008.05.006","volume":"45","author":"S Briganti","year":"2008","unstructured":"Briganti S, Wlaschek M, Hinrichs C, Bellei B, Flori E, Treiber N, Iben S, Picardo M, Scharffetter-Kochanek K (2008) Small molecular antioxidants effectively protect from PUVA-induced oxidative stress responses underlying fibroblast senescence and photoaging. Free Radic Biol Med 45(5):636\u2013644. https:\/\/doi.org\/10.1016\/j.freeradbiomed.2008.05.006","journal-title":"Free Radic Biol Med"},{"key":"2095_CR20","doi-asserted-by":"publisher","first-page":"1087","DOI":"10.3389\/fonc.2019.01087","volume":"9","author":"JK Bujak","year":"2019","unstructured":"Bujak JK, Kosmala D, Szopa IM, Majchrzak K, Bednarczyk P (2019) Inflammation, cancer and immunity-implication of TRPV1 channel. Front Oncol 9:1087. https:\/\/doi.org\/10.3389\/fonc.2019.01087","journal-title":"Front Oncol"},{"issue":"1","key":"2095_CR21","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1016\/j.jdermsci.2005.06.005","volume":"40","author":"S Cai","year":"2005","unstructured":"Cai S, Fatherazi S, Presland RB, Belton CM, Izutsu KT (2005) TRPC channel expression during calcium-induced differentiation of human gingival keratinocytes. J Dermatol Sci 40(1):21\u201328. https:\/\/doi.org\/10.1016\/j.jdermsci.2005.06.005","journal-title":"J Dermatol Sci"},{"issue":"1","key":"2095_CR22","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1007\/s00424-005-0001-1","volume":"452","author":"S Cai","year":"2006","unstructured":"Cai S, Fatherazi S, Presland RB, Belton CM, Roberts FA, Goodwin PC, Schubert MM, Izutsu KT (2006) Evidence that TRPC1 contributes to calcium-induced differentiation of human keratinocytes. Pflugers Arch 452(1):43\u201352. https:\/\/doi.org\/10.1007\/s00424-005-0001-1","journal-title":"Pflugers Arch"},{"issue":"4","key":"2095_CR23","doi-asserted-by":"publisher","first-page":"3011","DOI":"10.3390\/nu7043011","volume":"7","author":"MT Cantorna","year":"2015","unstructured":"Cantorna MT, Snyder L, Lin YD, Yang L (2015) Vitamin D and 1,25(OH)2D regulation of T cells. Nutrients 7(4):3011\u20133021. https:\/\/doi.org\/10.3390\/nu7043011","journal-title":"Nutrients"},{"issue":"10","key":"2095_CR24","doi-asserted-by":"publisher","first-page":"2499","DOI":"10.1016\/j.jid.2021.03.015","volume":"141","author":"L Cao","year":"2021","unstructured":"Cao L, Yue X, Zhao Y, Du L, Xie Z, Yuan Y, Zhang S, Li F, Feng J, Hu H (2021) Mechanisms of broad-band UVB irradiation\u2012induced itch in mice. J Invest Dermatol 141(10):2499-2508.e3. https:\/\/doi.org\/10.1016\/j.jid.2021.03.015","journal-title":"J Invest Dermatol"},{"issue":"6653","key":"2095_CR25","doi-asserted-by":"publisher","first-page":"816","DOI":"10.1038\/39807","volume":"389","author":"MJ Caterina","year":"1997","unstructured":"Caterina MJ, Schumacher MA, Tominaga M, Rosen TA, Levine JD, Julius D (1997) The capsaicin receptor: a heat-activated ion channel in the pain pathway. Nature 389(6653):816\u2013824. https:\/\/doi.org\/10.1038\/39807","journal-title":"Nature"},{"issue":"4","key":"2095_CR26","doi-asserted-by":"publisher","first-page":"77","DOI":"10.3390\/ph9040077","volume":"9","author":"MJ Caterina","year":"2016","unstructured":"Caterina MJ, Pang Z (2016) TRP channels in skin biology and pathophysiology. Pharmaceuticals (Basel) 9(4):77. https:\/\/doi.org\/10.3390\/ph9040077","journal-title":"Pharmaceuticals (Basel)"},{"key":"2095_CR27","doi-asserted-by":"publisher","first-page":"111950","DOI":"10.1016\/j.biopha.2021.111950","volume":"141","author":"TC Chan","year":"2021","unstructured":"Chan TC, Lee MS, Huang WC, Chang WY, Krueger JG, Tsai TF (2021) Capsaicin attenuates imiquimod-induced epidermal hyperplasia and cutaneous inflammation in a murine model of psoriasis. Biomed Pharmacother 141:111950. https:\/\/doi.org\/10.1016\/j.biopha.2021.111950","journal-title":"Biomed Pharmacother"},{"issue":"4","key":"2095_CR28","doi-asserted-by":"publisher","first-page":"670","DOI":"10.1124\/dmd.107.019240","volume":"36","author":"S Chanda","year":"2008","unstructured":"Chanda S, Bashir M, Babbar S, Koganti A, Bley K (2008) In vitro hepatic and skin metabolism of capsaicin. Drug Metab Dispos 36(4):670\u2013675. https:\/\/doi.org\/10.1124\/dmd.107.019240","journal-title":"Drug Metab Dispos"},{"key":"2095_CR29","doi-asserted-by":"publisher","first-page":"117765","DOI":"10.1016\/j.biopha.2024.117765","volume":"182","author":"CC Chen","year":"2025","unstructured":"Chen CC, Hung TM, Huang YJ, Hung HS, Hu CM, Lee PH (2025) Tacrolimus regulates extracellular vesicle secretion from T cells via autophagy-lysosomal pathway. Biomed Pharmacother 182:117765. https:\/\/doi.org\/10.1016\/j.biopha.2024.117765. (Erratum in: Biomed Pharmacother 184:117935. Doi: 10.1016\/j.biopha.2025.117935)","journal-title":"Biomed Pharmacother"},{"issue":"3","key":"2095_CR30","doi-asserted-by":"publisher","first-page":"202","DOI":"10.3109\/09546634.2014.927816","volume":"26","author":"YM Choi","year":"2015","unstructured":"Choi YM, Adelzadeh L, Wu JJ (2015) Photodynamic therapy for psoriasis. J Dermatolog Treat 26(3):202\u2013207. https:\/\/doi.org\/10.3109\/09546634.2014.927816","journal-title":"J Dermatolog Treat"},{"issue":"4","key":"2095_CR31","doi-asserted-by":"publisher","first-page":"919","DOI":"10.1016\/j.cell.2019.06.022","volume":"178","author":"JA Cohen","year":"2019","unstructured":"Cohen JA, Edwards TN, Liu AW, Hirai T, Jones MR, Wu J, Li Y, Zhang S, Ho J, Davis BM, Albers KM, Kaplan DH (2019) Cutaneous TRPV1+ neurons trigger protective innate type 17 anticipatory immunity. Cell 178(4):919-932.e14. https:\/\/doi.org\/10.1016\/j.cell.2019.06.022","journal-title":"Cell"},{"issue":"4","key":"2095_CR32","doi-asserted-by":"publisher","first-page":"1083","DOI":"10.3892\/ijmm.2016.2718","volume":"38","author":"S Cubillos","year":"2016","unstructured":"Cubillos S, Norgauer J (2016) Low vitamin D-modulated calcium-regulating proteins in psoriasis vulgaris plaques: S100A7 overexpression depends on joint involvement. Int J Mol Med 38(4):1083\u20131092. https:\/\/doi.org\/10.3892\/ijmm.2016.2718","journal-title":"Int J Mol Med"},{"key":"2095_CR33","doi-asserted-by":"publisher","first-page":"177291","DOI":"10.1016\/j.ejphar.2025.177291","volume":"994","author":"AM da Silva","year":"2025","unstructured":"da Silva AM, de Amorim Ferreira M, Schran RG, L\u00fcckemeyer DD, Prudente AS, Ferreira J (2025) Investigation of the participation of the TRPV1 receptor in the irritant effect of dithranol in mice. Eur J Pharmacol 994:177291. https:\/\/doi.org\/10.1016\/j.ejphar.2025.177291","journal-title":"Eur J Pharmacol"},{"issue":"2","key":"2095_CR34","doi-asserted-by":"publisher","first-page":"168","DOI":"10.1001\/archdermatol.2010.286","volume":"147","author":"RS Dawe","year":"2011","unstructured":"Dawe RS, Cameron HM, Yule S, Ibbotson SH, Moseley HH, Ferguson J (2011) A randomized comparison of methods of selecting narrowband UV-B starting dose to treat chronic psoriasis. Arch Dermatol 147(2):168\u2013174. https:\/\/doi.org\/10.1001\/archdermatol.2010.286","journal-title":"Arch Dermatol"},{"issue":"1","key":"2095_CR35","doi-asserted-by":"publisher","first-page":"142","DOI":"10.1016\/j.jid.2022.08.034","volume":"143","author":"F De Logu","year":"2023","unstructured":"De Logu F, Maglie R, Titiz M, Poli G, Landini L, Marini M, de Souza Monteiro Araujo D, De Siena G, Montini M, Cabrini DA, Otuki MF, Pawloski PL, Antiga E, Tuccinardi T, Calixto JB, Geppetti P, Nassini R, Andr\u00e9 E (2023) miRNA-203b-3p induces acute and chronic pruritus through 5-HTR2B and TRPV4. J Invest Dermatol 143(1):142-153.e10. https:\/\/doi.org\/10.1016\/j.jid.2022.08.034","journal-title":"J Invest Dermatol"},{"issue":"2","key":"2095_CR36","doi-asserted-by":"publisher","first-page":"108","DOI":"10.1016\/j.jdermsci.2009.11.007","volume":"57","author":"S Denda","year":"2010","unstructured":"Denda S, Denda M, Inoue K, Hibino T (2010) Glycolic acid induces keratinocyte proliferation in a skin equivalent model via TRPV1 activation. J Dermatol Sci 57(2):108\u2013113. https:\/\/doi.org\/10.1016\/j.jdermsci.2009.11.007","journal-title":"J Dermatol Sci"},{"issue":"5","key":"2095_CR37","doi-asserted-by":"publisher","first-page":"525","DOI":"10.1111\/ijd.12365","volume":"53","author":"S Dogra","year":"2014","unstructured":"Dogra S, Yadav S (2014) Acitretin in psoriasis: an evolving scenario. Int J Dermatol 53(5):525\u2013538. https:\/\/doi.org\/10.1111\/ijd.12365","journal-title":"Int J Dermatol"},{"issue":"6","key":"2095_CR38","doi-asserted-by":"publisher","first-page":"1415","DOI":"10.5114\/aoms.2018.79485","volume":"15","author":"A Dogru","year":"2019","unstructured":"Dogru A, Naz\u0131roglu M, Cig B (2019) Modulator role of infliximab and methotrexate through the transient receptor potential melastatin 2 (TRPM2) channel in neutrophils of patients with rheumatoid arthritis: a pilot study. Arch Med Sci 15(6):1415\u20131424. https:\/\/doi.org\/10.5114\/aoms.2018.79485","journal-title":"Arch Med Sci"},{"issue":"8","key":"2095_CR39","doi-asserted-by":"publisher","first-page":"768","DOI":"10.1016\/j.neuint.2009.07.011","volume":"55","author":"J El Andaloussi-Lilja","year":"2009","unstructured":"El Andaloussi-Lilja J, Lundqvist J, Forsby A (2009) TRPV1 expression and activity during retinoic acid-induced neuronal differentiation. Neurochem Int 55(8):768\u2013774. https:\/\/doi.org\/10.1016\/j.neuint.2009.07.011","journal-title":"Neurochem Int"},{"issue":"3","key":"2095_CR40","doi-asserted-by":"publisher","first-page":"438","DOI":"10.1016\/0190-9622(93)70208-b","volume":"29","author":"CN Ellis","year":"1993","unstructured":"Ellis CN, Berberian B, Sulica VI, Dodd WA, Jarratt MT, Katz HI, Prawer S, Krueger G, Rex IH Jr, Wolf JE (1993) A double-blind evaluation of topical capsaicin in pruritic psoriasis. J Am Acad Dermatol 29(3):438\u2013442. https:\/\/doi.org\/10.1016\/0190-9622(93)70208-b","journal-title":"J Am Acad Dermatol"},{"issue":"3","key":"2095_CR41","doi-asserted-by":"publisher","first-page":"775","DOI":"10.1016\/j.jaad.2019.04.042","volume":"81","author":"CA Elmets","year":"2019","unstructured":"Elmets CA, Lim HW, Stoff B et al (2019) Joint American Academy of Dermatology-National Psoriasis Foundation guidelines of care for the management and treatment of psoriasis with phototherapy. J Am Acad Dermatol 81(3):775\u2013804. https:\/\/doi.org\/10.1016\/j.jaad.2019.04.042","journal-title":"J Am Acad Dermatol"},{"issue":"2","key":"2095_CR42","doi-asserted-by":"publisher","first-page":"432","DOI":"10.1016\/j.jaad.2020.07.087","volume":"84","author":"CA Elmets","year":"2021","unstructured":"Elmets CA, Korman NJ, Prater EF et al (2021) Joint AAD-NPF guidelines of care for the management and treatment of psoriasis with topical therapy and alternative medicine modalities for psoriasis severity measures. J Am Acad Dermatol 84(2):432\u2013470. https:\/\/doi.org\/10.1016\/j.jaad.2020.07.087","journal-title":"J Am Acad Dermatol"},{"issue":"4","key":"2095_CR43","doi-asserted-by":"publisher","first-page":"428","DOI":"10.1111\/j.1529-8019.2010.01345.x","volume":"23","author":"M El-Mofty","year":"2010","unstructured":"El-Mofty M, Mostafa WZ, Bosseila M, Youssef R, Esmat S, El Ramly A, Fawzi M, Mahgoub D, Nagui N, Mashaly HM, El-Fangary M, Fathy M (2010) A large-scale analytical study on efficacy of different photo(chemo)therapeutic modalities in the treatment of psoriasis, vitiligo and mycosis fungoides. Dermatol Ther 23(4):428\u2013434. https:\/\/doi.org\/10.1111\/j.1529-8019.2010.01345.x","journal-title":"Dermatol Ther"},{"issue":"25","key":"2095_CR44","doi-asserted-by":"publisher","first-page":"e2401583","DOI":"10.1002\/advs.202401583","volume":"11","author":"J Fan","year":"2024","unstructured":"Fan J, Guo C, Liao D, Ke H, Lei J, Xie W, Tang Y, Tominaga M, Huang Z, Lei X (2024) Structural pharmacology of TRPV4 antagonists. Adv Sci (Weinh) 11(25):e2401583. https:\/\/doi.org\/10.1002\/advs.202401583","journal-title":"Adv Sci (Weinh)"},{"issue":"7","key":"2095_CR45","doi-asserted-by":"publisher","first-page":"844","DOI":"10.3390\/molecules21070844","volume":"21","author":"V Fattori","year":"2016","unstructured":"Fattori V, Hohmann MS, Rossaneis AC, Pinho-Ribeiro FA, Verri WA (2016) Capsaicin: current understanding of its mechanisms and therapy of pain and other pre-clinical and clinical uses. Molecules 21(7):844. https:\/\/doi.org\/10.3390\/molecules21070844","journal-title":"Molecules"},{"issue":"4","key":"2095_CR46","doi-asserted-by":"publisher","first-page":"428","DOI":"10.1111\/1523-1747.ep12555582","volume":"95","author":"GJ Fisher","year":"1990","unstructured":"Fisher GJ, Talwar HS, Baldassare JJ, Henderson PA, Voorhees JJ (1990) Increased phospholipase C-catalyzed hydrolysis of phosphatidylinositol-4,5-bisphosphate and 1,2-sn-diacylglycerol content in psoriatic involved compared to uninvolved and normal epidermis. J Invest Dermatol 95(4):428\u2013435. https:\/\/doi.org\/10.1111\/1523-1747.ep12555582","journal-title":"J Invest Dermatol"},{"key":"2095_CR47","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1007\/s12326-018-0279-3","volume":"17","author":"K Fritz","year":"2018","unstructured":"Fritz K, Salavastru C (2018) 308 nm excimer laser for the treatment of psoriasis and inflammatory skin diseases. Hautnah 17:92\u2013101. https:\/\/doi.org\/10.1007\/s12326-018-0279-3","journal-title":"Hautnah"},{"issue":"3","key":"2095_CR48","doi-asserted-by":"publisher","first-page":"130","DOI":"10.1007\/s00432-024-05648-y","volume":"150","author":"P Galiatsatos","year":"2024","unstructured":"Galiatsatos P, Maydan DD, Macalpine E, Schleupner B, Aitchison AH, Lerner AD, Levy B, Halthore A, Eward W (2024) Psoralen: a narrative review of current and future therapeutic uses. J Cancer Res Clin Oncol 150(3):130. https:\/\/doi.org\/10.1007\/s00432-024-05648-y","journal-title":"J Cancer Res Clin Oncol"},{"issue":"3","key":"2095_CR49","doi-asserted-by":"publisher","first-page":"663","DOI":"10.1007\/s13555-025-01353-x","volume":"15","author":"EJ Goddard","year":"2025","unstructured":"Goddard EJ, Haughton JM, Lucas JE, Barlow SG, Fitzgerald TP, Litvintchouk AM, Wu D (2025) Patient disease characteristics and treatment patterns in mild-moderate psoriasis: results from real-world clinical practice in the United States (PROSPECT Study). Dermatol Ther (Heidelb) 15(3):663\u2013680. https:\/\/doi.org\/10.1007\/s13555-025-01353-x","journal-title":"Dermatol Ther (Heidelb)"},{"issue":"1","key":"2095_CR50","doi-asserted-by":"publisher","first-page":"437","DOI":"10.1038\/s41392-023-01655-6","volume":"8","author":"J Guo","year":"2023","unstructured":"Guo J, Zhang H, Lin W, Lu L, Su J, Chen X (2023) Signaling pathways and targeted therapies for psoriasis. Signal Transduct Target Ther 8(1):437. https:\/\/doi.org\/10.1038\/s41392-023-01655-6. (Erratum in: Signal Transduct Target Ther. 2024 22;9(1):25. doi: 10.1038\/s41392-023-01733-9)","journal-title":"Signal Transduct Target Ther"},{"issue":"1","key":"2095_CR51","doi-asserted-by":"publisher","first-page":"11","DOI":"10.3109\/09546639709160502","volume":"8","author":"C Grattan","year":"1997","unstructured":"Grattan C, Hallam F, Whitefield M (1997) A new aqueous dithranol gel for psoriasis: comparison with placebo and calcipotriol ointment. J Dermatolog Treat 8(1):11\u201315. https:\/\/doi.org\/10.3109\/09546639709160502","journal-title":"J Dermatolog Treat"},{"issue":"10281","key":"2095_CR52","doi-asserted-by":"publisher","first-page":"1301","DOI":"10.1016\/S0140-6736(20)32549-6","volume":"397","author":"CEM Griffiths","year":"2021","unstructured":"Griffiths CEM, Armstrong AW, Gudjonsson JE, Barker JNWN (2021) Psoriasis. Lancet (London, England) 397(10281):1301\u20131315. https:\/\/doi.org\/10.1016\/S0140-6736(20)32549-6","journal-title":"Lancet (London, England)"},{"key":"2095_CR53","doi-asserted-by":"publisher","DOI":"10.1038\/nrdp.2016.82","author":"JE Greb","year":"2016","unstructured":"Greb JE, Goldminz AM, Elder JT, Lebwohl MG, Gladman DD, Wu JJ, Mehta NN, Finlay AY, Gottlieb AB (2016) Psoriasis. Nat Rev Dis Primers. https:\/\/doi.org\/10.1038\/nrdp.2016.82","journal-title":"Nat Rev Dis Primers"},{"key":"2095_CR54","doi-asserted-by":"publisher","first-page":"338","DOI":"10.1016\/j.freeradbiomed.2019.07.005","volume":"141","author":"AK Herrmann","year":"2019","unstructured":"Herrmann AK, W\u00fcllner V, Moos S, Graf J, Chen J, Kieseier B, Kurschus FC, Albrecht P, Vangheluwe P, Methner A (2019) Dimethyl fumarate alters intracellular Ca2+ handling in immune cells by redox-mediated pleiotropic effects. Free Radic Biol Med 141:338\u2013347. https:\/\/doi.org\/10.1016\/j.freeradbiomed.2019.07.005","journal-title":"Free Radic Biol Med"},{"issue":"3","key":"2095_CR55","doi-asserted-by":"publisher","first-page":"1082","DOI":"10.1111\/j.1523-1755.2004.00858.x","volume":"66","author":"JG Hoenderop","year":"2004","unstructured":"Hoenderop JG, van der Kemp AW, Urben CM, Strugnell SA, Bindels RJ (2004) Effects of vitamin D compounds on renal and intestinal Ca2+ transport proteins in 25-hydroxyvitamin D3-1alpha-hydroxylase knockout mice. Kidney Int 66(3):1082\u20131089. https:\/\/doi.org\/10.1111\/j.1523-1755.2004.00858.x","journal-title":"Kidney Int"},{"issue":"6716","key":"2095_CR56","doi-asserted-by":"publisher","first-page":"259","DOI":"10.1038\/16711","volume":"397","author":"T Hofmann","year":"1999","unstructured":"Hofmann T, Obukhov AG, Schaefer M, Harteneck C, Gudermann T, Schultz G (1999) Direct activation of human TRPC6 and TRPC3 channels by diacylglycerol. Nature 397(6716):259\u2013263. https:\/\/doi.org\/10.1038\/16711","journal-title":"Nature"},{"issue":"2","key":"2095_CR57","doi-asserted-by":"publisher","first-page":"e151","DOI":"10.1111\/1346-8138.17431","volume":"52","author":"DM Hsieh","year":"2015","unstructured":"Hsieh DM, Shang P, Gao Y, Zhao J (2015) Successful treatment with spesolimab for generalized pustular psoriasis in an elderly patient with TRPM4 mutation. J Dermatol 52(2):e151\u2013e152. https:\/\/doi.org\/10.1111\/1346-8138.17431","journal-title":"J Dermatol"},{"issue":"4","key":"2095_CR58","doi-asserted-by":"publisher","first-page":"543","DOI":"10.1097\/j.pain.0000000000000831","volume":"158","author":"S Iyengar","year":"2017","unstructured":"Iyengar S, Ossipov MH, Johnson KW (2017) The role of calcitonin gene-related peptide in peripheral and central pain mechanisms including migraine. Pain 158(4):543\u2013559. https:\/\/doi.org\/10.1097\/j.pain.0000000000000831","journal-title":"Pain"},{"issue":"6","key":"2095_CR59","doi-asserted-by":"publisher","first-page":"449","DOI":"10.2340\/0001555572449450","volume":"72","author":"J Jekler","year":"1992","unstructured":"Jekler J, Swanbeck G (1992) One-minute dithranol therapy in psoriasis: a placebo-controlled paired comparative study. Acta Derm Venereol 72(6):449\u2013450 (PMID: 1362841)","journal-title":"Acta Derm Venereol"},{"issue":"1","key":"2095_CR60","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1111\/bcp.14370","volume":"87","author":"V Joseph","year":"2021","unstructured":"Joseph V, Yang X, Gao SS, Elstrott J, Weimer RM, Theess W, Thrasher C, Singh N, Lin J, Bauer RN (2021) Development of AITC-induced dermal blood flow as a translational in vivo biomarker of TRPA1 activity in human and rodent skin. Br J Clin Pharmacol 87(1):129\u2013139. https:\/\/doi.org\/10.1111\/bcp.14370","journal-title":"Br J Clin Pharmacol"},{"issue":"2","key":"2095_CR61","doi-asserted-by":"publisher","first-page":"175","DOI":"10.2340\/00015555-3065","volume":"99","author":"K Kaaz","year":"2019","unstructured":"Kaaz K, Szepietowski JC, Matusiak \u0141 (2019) Influence of itch and pain on sleep quality in atopic dermatitis and psoriasis. Acta Derm Venereol 99(2):175\u2013180. https:\/\/doi.org\/10.2340\/00015555-3065","journal-title":"Acta Derm Venereol"},{"issue":"19","key":"2095_CR62","doi-asserted-by":"publisher","first-page":"14734","DOI":"10.3390\/ijms241914734","volume":"24","author":"A Kaczmarska","year":"2023","unstructured":"Kaczmarska A, Kwiatkowska D, Skrzypek KK, Kowalewski ZT, Jaworecka K, Reich A (2023) Pathomechanism of pruritus in psoriasis and atopic dermatitis: novel approaches, similarities and differences. Int J Mol Sci 24(19):14734. https:\/\/doi.org\/10.3390\/ijms241914734","journal-title":"Int J Mol Sci"},{"issue":"2","key":"2095_CR63","doi-asserted-by":"publisher","first-page":"305","DOI":"10.1007\/s12576-018-0647-z","volume":"69","author":"T Kita","year":"2019","unstructured":"Kita T, Uchida K, Kato K, Suzuki Y, Tominaga M, Yamazaki J (2019) FK506 (tacrolimus) causes pain sensation through the activation of transient receptor potential ankyrin 1 (TRPA1) channels. J Physiol Sci 69(2):305\u2013316. https:\/\/doi.org\/10.1007\/s12576-018-0647-z","journal-title":"J Physiol Sci"},{"issue":"8","key":"2095_CR64","doi-asserted-by":"publisher","first-page":"1774","DOI":"10.1016\/j.jid.2018.02.040","volume":"138","author":"\u00c1 Kem\u00e9ny","year":"2018","unstructured":"Kem\u00e9ny \u00c1, Kodji X, Horv\u00e1th S, Koml\u00f3di R, Sz\u0151ke \u00c9, S\u00e1ndor Z, Perkecz A, Gy\u00f6m\u00f6rei C, S\u00e9t\u00e1l\u00f3 G, Kelemen B, B\u00edr\u00f3 T, T\u00f3th BI, Brain SD, Pint\u00e9r E, Gyulai R (2018) TRPA1 acts in a protective manner in imiquimod-induced psoriasiform dermatitis in mice. J Invest Dermatol 138(8):1774\u20131784. https:\/\/doi.org\/10.1016\/j.jid.2018.02.040","journal-title":"J Invest Dermatol"},{"issue":"2","key":"2095_CR65","doi-asserted-by":"publisher","first-page":"1578","DOI":"10.1096\/fj.201800395RR","volume":"33","author":"X Kodji","year":"2019","unstructured":"Kodji X, Arkless KL, Kee Z, Cleary SJ, Aubdool AA, Evans E, Caton P, Pitchford SC, Brain SD (2019) Sensory nerves mediate spontaneous behaviors in addition to inflammation in a murine model of psoriasis. FASEB J 33(2):1578\u20131594. https:\/\/doi.org\/10.1096\/fj.201800395RR. (Erratum in: FASEB J 33(12):14841. 10.1096\/fj.201800395RRERR)","journal-title":"FASEB J"},{"issue":"1","key":"2095_CR66","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1038\/s41573-021-00268-4","volume":"21","author":"AP Koivisto","year":"2022","unstructured":"Koivisto AP, Belvisi MG, Gaudet R, Szallasi A (2022) Advances in TRP channel drug discovery: from target validation to clinical studies. Nat Rev Drug Discov 21(1):41\u201359. https:\/\/doi.org\/10.1038\/s41573-021-00268-4","journal-title":"Nat Rev Drug Discov"},{"issue":"3","key":"2095_CR67","doi-asserted-by":"publisher","first-page":"318","DOI":"10.1007\/s10517-015-2951-4","volume":"159","author":"AA Kubanov","year":"2015","unstructured":"Kubanov AA, Katunina OR, Chikin VV (2015) Expression of neuropeptides, neurotrophins, and neurotransmitters in the skin of patients with atopic dermatitis and psoriasis. Bull Exp Biol Med 159(3):318\u2013322. https:\/\/doi.org\/10.1007\/s10517-015-2951-4","journal-title":"Bull Exp Biol Med"},{"key":"2095_CR68","doi-asserted-by":"publisher","first-page":"7489316","DOI":"10.1155\/2018\/7489316","volume":"2018","author":"P Kupczyk","year":"2018","unstructured":"Kupczyk P, Reich A, Gajda M, Ho\u0142ysz M, Wysoki\u0144ska E, Paprocka M, Nevozhay D, Chodaczek G, Jagodzi\u0144ski PP, Zi\u00f3\u0142kowski P, Szepietowski JC (2018) UCHL1\/PGP 9.5 dynamic in neuro-immune-cutaneous milieu: focusing on axonal nerve terminals and epidermal keratinocytes in psoriatic itch. Biomed Res Int 2018:7489316. https:\/\/doi.org\/10.1155\/2018\/7489316","journal-title":"Biomed Res Int"},{"issue":"2","key":"2095_CR69","doi-asserted-by":"publisher","first-page":"170","DOI":"10.1002\/jlb.64.2.170","volume":"64","author":"RW Lange","year":"1998","unstructured":"Lange RW, Germolec DR, Foley JF, Luster MI (1998) Antioxidants attenuate anthralin-induced skin inflammation in BALB\/c mice: role of specific proinflammatory cytokines. J Leukoc Biol 64(2):170\u2013176. https:\/\/doi.org\/10.1002\/jlb.64.2.170","journal-title":"J Leukoc Biol"},{"issue":"3","key":"2095_CR70","doi-asserted-by":"publisher","first-page":"1110","DOI":"10.1016\/j.jaci.2020.09.028","volume":"147","author":"C Larkin","year":"2021","unstructured":"Larkin C, Chen W, Szab\u00f3 IL, Shan C, Dajnoki Z, Szegedi A, Buhl T, Fan Y, O\u2019Neill S, Walls D, Cheng W, Xiao S, Wang J, Meng J (2021) Novel insights into the TRPV3-mediated itch in atopic dermatitis. J Allergy Clin Immunol 147(3):1110-1114.e5. https:\/\/doi.org\/10.1016\/j.jaci.2020.09.028","journal-title":"J Allergy Clin Immunol"},{"key":"2095_CR71","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdermsci.2018.04.017","author":"JH Lee","year":"2018","unstructured":"Lee JH, Choi CS, Bae IH, Choi JK, Park YH, Park M (2018) A novel, topical, nonsteroidal, TRPV1 antagonist, PAC-14028 cream improves skin barrier function and exerts anti-inflammatory action through modulating epidermal differentiation markers and suppressing Th2 cytokines in atopic dermatitis. J Dermatol Sci. https:\/\/doi.org\/10.1016\/j.jdermsci.2018.04.017","journal-title":"J Dermatol Sci"},{"issue":"17","key":"2095_CR72","doi-asserted-by":"publisher","first-page":"13313","DOI":"10.3390\/ijms241713313","volume":"24","author":"HJ Lee","year":"2023","unstructured":"Lee HJ, Kim M (2023) Challenges and future trends in the treatment of psoriasis. Int J Mol Sci 24(17):13313. https:\/\/doi.org\/10.3390\/ijms241713313","journal-title":"Int J Mol Sci"},{"issue":"26","key":"2095_CR73","doi-asserted-by":"publisher","first-page":"12111","DOI":"10.7150\/thno.52135","volume":"10","author":"SH Lee","year":"2020","unstructured":"Lee SH, Tonello R, Im ST, Jeon H, Park J, Ford Z, Davidson S, Kim YH, Park CK, Berta T (2020) Resolvin D3 controls mouse and human TRPV1-positive neurons and preclinical progression of psoriasis. Theranostics 10(26):12111\u201312126. https:\/\/doi.org\/10.7150\/thno.52135","journal-title":"Theranostics"},{"issue":"31","key":"2095_CR74","doi-asserted-by":"publisher","first-page":"22582","DOI":"10.1074\/jbc.M611398200","volume":"282","author":"V Lehen\u2019kyi","year":"2007","unstructured":"Lehen\u2019kyi V, Beck B, Polakowska R, Charveron M, Bordat P, Skryma R, Prevarskaya N (2007) TRPV6 is a Ca2+ entry channel essential for Ca2+-induced differentiation of human keratinocytes. J Biol Chem 282(31):22582\u201322591. https:\/\/doi.org\/10.1074\/jbc.M611398200","journal-title":"J Biol Chem"},{"issue":"1","key":"2095_CR75","doi-asserted-by":"publisher","first-page":"83","DOI":"10.3109\/09546634.2013.782091","volume":"25","author":"S Lembo","year":"2014","unstructured":"Lembo S, Capasso R, Balato A, Cirillo T, Flora F, Zappia V, Balato N, Ingrosso D, Ayala F (2014) MCP-1 in psoriatic patients: effect of biological therapy. J Dermatolog Treat 25(1):83\u201386. https:\/\/doi.org\/10.3109\/09546634.2013.782091","journal-title":"J Dermatolog Treat"},{"issue":"2","key":"2095_CR76","doi-asserted-by":"publisher","first-page":"e14716","DOI":"10.1371\/journal.pone.0014716","volume":"6","author":"K Leuner","year":"2011","unstructured":"Leuner K, Kraus M, Woelfle U, Beschmann H, Harteneck C, Boehncke WH, Schempp CM, M\u00fcller WE (2011) Reduced TRPC channel expression in psoriatic keratinocytes is associated with impaired differentiation and enhanced proliferation. PLoS ONE 6(2):e14716. https:\/\/doi.org\/10.1371\/journal.pone.0014716","journal-title":"PLoS ONE"},{"issue":"7","key":"2095_CR77","doi-asserted-by":"publisher","first-page":"1674","DOI":"10.1523\/JNEUROSCI.3632-04.2005","volume":"25","author":"B Liu","year":"2005","unstructured":"Liu B, Qin F (2005) Functional control of cold- and menthol-sensitive TRPM8 ion channels by phosphatidylinositol 4,5-bisphosphate. J Neurosci 25(7):1674\u20131681. https:\/\/doi.org\/10.1523\/JNEUROSCI.3632-04.2005","journal-title":"J Neurosci"},{"issue":"7","key":"2095_CR78","doi-asserted-by":"publisher","first-page":"1344","DOI":"10.1111\/jdv.19088","volume":"37","author":"P Liu","year":"2023","unstructured":"Liu P, Zhou Y, Chen C, Yan B, Li L, Zhu W, Li J, Chen M, Su J, Kuang Y, Chen X, Peng C (2023) Lysophosphatidylcholine facilitates the pathogenesis of psoriasis through activating keratinocytes and T cells differentiation via glycolysis. J Eur Acad Dermatol Venereol 37(7):1344\u20131360. https:\/\/doi.org\/10.1111\/jdv.19088","journal-title":"J Eur Acad Dermatol Venereol"},{"issue":"19","key":"2095_CR79","doi-asserted-by":"publisher","first-page":"4321","DOI":"10.1113\/JP279961","volume":"598","author":"W Long","year":"2020","unstructured":"Long W, Fatehi M, Soni S, Panigrahi R, Philippaert K, Yu Y, Kelly R, Boonen B, Barr A, Golec D, Campbell SA, Ondrusova K, Hubert M, Baldwin T, Lemieux MJ, Light PE (2020) Vitamin D is an endogenous partial agonist of the transient receptor potential vanilloid 1 channel. J Physiol 598(19):4321\u20134338. https:\/\/doi.org\/10.1113\/JP279961","journal-title":"J Physiol"},{"issue":"1","key":"2095_CR80","doi-asserted-by":"publisher","first-page":"360","DOI":"10.1080\/19336950.2021.1905248","volume":"15","author":"W Long","year":"2021","unstructured":"Long W, Johnson J, Kalyaanamoorthy S, Light P (2021) TRPV1 channels as a newly identified target for vitamin D. Channels (Austin) 15(1):360\u2013374. https:\/\/doi.org\/10.1080\/19336950.2021.1905248","journal-title":"Channels (Austin)"},{"issue":"17","key":"2095_CR81","doi-asserted-by":"publisher","first-page":"2691","DOI":"10.1016\/j.neuron.2021.06.015","volume":"109","author":"X Luo","year":"2021","unstructured":"Luo X, Chen O, Wang Z, Bang S, Ji J, Lee SH, Huh Y, Furutani K, He Q, Tao X, Ko MC, Bortsov A, Donnelly CR, Chen Y, Nackley A, Berta T, Ji RR (2021) IL-23\/IL-17A\/TRPV1 axis produces mechanical pain via macrophage-sensory neuron crosstalk in female mice. Neuron 109(17):2691-2706.e5. https:\/\/doi.org\/10.1016\/j.neuron.2021.06.015","journal-title":"Neuron"},{"issue":"7","key":"2095_CR82","doi-asserted-by":"publisher","first-page":"3322","DOI":"10.3390\/ijms22073322","volume":"22","author":"S Luostarinen","year":"2021","unstructured":"Luostarinen S, H\u00e4m\u00e4l\u00e4inen M, Moilanen E (2021) Transient receptor potential ankyrin 1 (TRPA1)-an inflammation-induced factor in human HaCaT keratinocytes. Int J Mol Sci 22(7):3322. https:\/\/doi.org\/10.3390\/ijms22073322","journal-title":"Int J Mol Sci"},{"key":"2095_CR83","doi-asserted-by":"publisher","DOI":"10.1111\/ijd.17723","author":"R Mahajan","year":"2025","unstructured":"Mahajan R, Sarkar R, Panda M et al (2025) Evidence-based recommendations for managing atopic dermatitis in pediatric patients: a systematic review and meta-analysis from the Pediatric Dermatology Special Interest Group of IADVL. Int J Dermatol. https:\/\/doi.org\/10.1111\/ijd.17723","journal-title":"Int J Dermatol"},{"issue":"14","key":"2095_CR84","doi-asserted-by":"publisher","first-page":"2661","DOI":"10.1111\/febs.13306","volume":"282","author":"RK Majhi","year":"2015","unstructured":"Majhi RK, Sahoo SS, Yadav M, Pratheek BM, Chattopadhyay S, Goswami C (2015) Functional expression of TRPV channels in T cells and their implications in immune regulation. FEBS J 282(14):2661\u20132681. https:\/\/doi.org\/10.1111\/febs.13306","journal-title":"FEBS J"},{"issue":"2","key":"2095_CR85","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1007\/s40257-016-0176-6","volume":"17","author":"D Mehta","year":"2016","unstructured":"Mehta D, Lim HW (2016) Ultraviolet B phototherapy for psoriasis: review of practical guidelines. Am J Clin Dermatol 17(2):125\u2013133. https:\/\/doi.org\/10.1007\/s40257-016-0176-6","journal-title":"Am J Clin Dermatol"},{"issue":"10","key":"2095_CR86","doi-asserted-by":"publisher","first-page":"e47617","DOI":"10.1371\/journal.pone.0047617","volume":"7","author":"N Melzer","year":"2012","unstructured":"Melzer N, Hicking G, G\u00f6bel K, Wiendl H (2012) TRPM2 cation channels modulate T cell effector functions and contribute to autoimmune CNS inflammation. PLoS ONE 7(10):e47617. https:\/\/doi.org\/10.1371\/journal.pone.0047617","journal-title":"PLoS ONE"},{"issue":"11","key":"2095_CR87","doi-asserted-by":"publisher","first-page":"3819","DOI":"10.3390\/ijms21113819","volume":"21","author":"KA M\u00e9ndez-Res\u00e9ndiz","year":"2020","unstructured":"M\u00e9ndez-Res\u00e9ndiz KA, Enciso-Pablo \u00d3, Gonz\u00e1lez-Ram\u00edrez R, Ju\u00e1rez-Contreras R, Rosenbaum T, Morales-L\u00e1zaro SL (2020) Steroids and TRP channels: a close relationship. Int J Mol Sci 21(11):3819. https:\/\/doi.org\/10.3390\/ijms21113819","journal-title":"Int J Mol Sci"},{"issue":"1","key":"2095_CR88","doi-asserted-by":"publisher","first-page":"114","DOI":"10.1016\/j.jaad.2009.08.026","volume":"62","author":"A Menter","year":"2010","unstructured":"Menter A, Korman NJ, Elmets CA et al (2010) Guidelines of care for the management of psoriasis and psoriatic arthritis: section\u2014guidelines of care for the treatment of psoriasis with phototherapy and photochemotherapy. J Am Acad Dermatol 62(1):114\u2013135. https:\/\/doi.org\/10.1016\/j.jaad.2009.08.026","journal-title":"J Am Acad Dermatol"},{"issue":"4","key":"2095_CR89","doi-asserted-by":"publisher","first-page":"1029","DOI":"10.1016\/j.jaad.2018.11.057","volume":"80","author":"A Menter","year":"2019","unstructured":"Menter A, Strober BE, Kaplan DH et al (2019) Joint AAD-NPF guidelines of care for the management and treatment of psoriasis with biologics. J Am Acad Dermatol 80(4):1029\u20131072. https:\/\/doi.org\/10.1016\/j.jaad.2018.11.057","journal-title":"J Am Acad Dermatol"},{"issue":"6","key":"2095_CR90","doi-asserted-by":"publisher","first-page":"1445","DOI":"10.1016\/j.jaad.2020.02.044","volume":"82","author":"A Menter","year":"2020","unstructured":"Menter A, Gelfand JM, Connor C et al (2020) Joint American Academy of Dermatology-National Psoriasis Foundation guidelines of care for the management of psoriasis with systemic nonbiologic therapies. J Am Acad Dermatol 82(6):1445\u20131486. https:\/\/doi.org\/10.1016\/j.jaad.2020.02.044","journal-title":"J Am Acad Dermatol"},{"issue":"6","key":"2095_CR91","doi-asserted-by":"publisher","first-page":"662","DOI":"10.4103\/ijd.ijd_679_22","volume":"67","author":"A Mohta","year":"2022","unstructured":"Mohta A, Nyati A (2022) Correlation of vitamin D3 levels with disease severity in psoriasis patients\u2014a case-control study. Indian J Dermatol 67(6):662\u2013666. https:\/\/doi.org\/10.4103\/ijd.ijd_679_22","journal-title":"Indian J Dermatol"},{"issue":"34","key":"2095_CR92","doi-asserted-by":"publisher","first-page":"E3225","DOI":"10.1073\/pnas.1312933110","volume":"110","author":"C Moore","year":"2013","unstructured":"Moore C, Cevikbas F, Pasolli HA, Chen Y, Kong W, Kempkes C, Parekh P, Lee SH, Kontchou NA, Yeh I, Jokerst NM, Fuchs E, Steinhoff M, Liedtke WB (2013) UVB radiation generates sunburn pain and affects skin by activating epidermal TRPV4 ion channels and triggering endothelin-1 signaling. Proc Natl Acad Sci U S A 110(34):E3225\u2013E3234. https:\/\/doi.org\/10.1073\/pnas.1312933110. (Erratum in: Proc Natl Acad Sci U S A (2013) 110(38):15502. Ye, Iwei [corrected to Yeh, Iwei])","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"49","key":"2095_CR93","doi-asserted-by":"publisher","first-page":"33942","DOI":"10.1074\/jbc.M801844200","volume":"283","author":"M M\u00fcller","year":"2008","unstructured":"M\u00fcller M, Essin K, Hill K, Beschmann H, Rubant S, Schempp CM, Gollasch M, Boehncke WH, Harteneck C, M\u00fcller WE, Leuner K (2008) Specific TRPC6 channel activation, a novel approach to stimulate keratinocyte differentiation. J Biol Chem 283(49):33942\u201333954. https:\/\/doi.org\/10.1074\/jbc.M801844200","journal-title":"J Biol Chem"},{"issue":"6","key":"2095_CR94","doi-asserted-by":"publisher","first-page":"1311","DOI":"10.1016\/j.jid.2017.12.029","volume":"138","author":"LA Nattkemper","year":"2018","unstructured":"Nattkemper LA, Tey HL, Valdes-Rodriguez R, Lee H, Mollanazar NK, Albornoz C, Sanders KM, Yosipovitch G (2018) The genetics of chronic itch: gene expression in the skin of patients with atopic dermatitis and psoriasis with severe itch. J Invest Dermatol 138(6):1311\u20131317. https:\/\/doi.org\/10.1016\/j.jid.2017.12.029","journal-title":"J Invest Dermatol"},{"key":"2095_CR95","doi-asserted-by":"publisher","first-page":"adv4463","DOI":"10.2340\/actadv.v103.4463","volume":"103","author":"LA Nattkemper","year":"2023","unstructured":"Nattkemper LA, Lipman ZM, Ingrasci G, Maldonado C, Garces JC, Loayza E, Yosipovitch G (2023) Neuroimmune mediators of pruritus in Hispanic scalp psoriatic itch. Acta Derm Venereol 103:adv4463. https:\/\/doi.org\/10.2340\/actadv.v103.4463","journal-title":"Acta Derm Venereol"},{"issue":"10","key":"2095_CR96","doi-asserted-by":"publisher","first-page":"1336","DOI":"10.1373\/clinchem.2014.223511","volume":"60","author":"OM Noceti","year":"2014","unstructured":"Noceti OM, Woillard JB, Boumediene A, Esper\u00f3n P, Taupin JL, Gerona S, Valverde M, Touri\u00f1o C, Marquet P (2014) Tacrolimus pharmacodynamics and pharmacogenetics along the calcineurin pathway in human lymphocytes. Clin Chem 60(10):1336\u20131345. https:\/\/doi.org\/10.1373\/clinchem.2014.223511","journal-title":"Clin Chem"},{"issue":"1\u20135","key":"2095_CR97","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1016\/s0960-0760(00)00145-x","volume":"76","author":"AW Norman","year":"2001","unstructured":"Norman AW, Ishizuka S, Okamura WH (2001) Ligands for the vitamin D endocrine system: different shapes function as agonists and antagonists for genomic and rapid response receptors or as a ligand for the plasma vitamin D binding protein. J Steroid Biochem Mol Biol 76(1\u20135):49\u201359. https:\/\/doi.org\/10.1016\/s0960-0760(00)00145-x","journal-title":"J Steroid Biochem Mol Biol"},{"issue":"16","key":"2095_CR98","doi-asserted-by":"publisher","first-page":"6289","DOI":"10.1523\/JNEUROSCI.20-16-06289.2000","volume":"20","author":"A Opr\u00e9e","year":"2000","unstructured":"Opr\u00e9e A, Kress M (2000) Involvement of the proinflammatory cytokines tumor necrosis factor-alpha, IL-1 beta, and IL-6 but not IL-8 in the development of heat hyperalgesia: effects on heat-evoked calcitonin gene-related peptide release from rat skin. J Neurosci 20(16):6289\u20136293. https:\/\/doi.org\/10.1523\/JNEUROSCI.20-16-06289.2000","journal-title":"J Neurosci"},{"issue":"7","key":"2095_CR99","doi-asserted-by":"publisher","first-page":"1530","DOI":"10.1038\/jid.2011.60","volume":"131","author":"SM Ostrowski","year":"2011","unstructured":"Ostrowski SM, Belkadi A, Loyd CM, Diaconu D, Ward NL (2011) Cutaneous denervation of psoriasiform mouse skin improves acanthosis and inflammation in a sensory neuropeptide-dependent manner. J Invest Dermatol 131(7):1530\u20131538. https:\/\/doi.org\/10.1038\/jid.2011.60","journal-title":"J Invest Dermatol"},{"issue":"8","key":"2095_CR100","doi-asserted-by":"publisher","first-page":"1234","DOI":"10.1177\/0960327121991911","volume":"40","author":"SS \u00d6zcan","year":"2021","unstructured":"\u00d6zcan SS, G\u00fcrel G, \u00c7ak\u0131r M (2021) Gene expression profiles of transient receptor potential (TRP) channels in the peripheral blood mononuclear cells of psoriasis patients. Hum Exp Toxicol 40(8):1234\u20131240. https:\/\/doi.org\/10.1177\/0960327121991911","journal-title":"Hum Exp Toxicol"},{"issue":"4","key":"2095_CR101","doi-asserted-by":"publisher","first-page":"1340","DOI":"10.1016\/j.jaci.2021.09.024","volume":"149","author":"CW Park","year":"2022","unstructured":"Park CW, Kim BJ, Lee YW, Won C, Park CO, Chung BY, Lee DH, Jung K, Nam HJ, Choi G, Park YH, Kim KH, Park M (2022) Asivatrep, a TRPV1 antagonist, for the topical treatment of atopic dermatitis: phase 3, randomized, vehicle-controlled study (CAPTAIN-AD). J Allergy Clin Immunol 149(4):1340-1347.e4. https:\/\/doi.org\/10.1016\/j.jaci.2021.09.024","journal-title":"J Allergy Clin Immunol"},{"issue":"3","key":"2095_CR102","doi-asserted-by":"publisher","first-page":"469","DOI":"10.1046\/j.1365-2133.1999.03040.x","volume":"141","author":"R Parslew","year":"1999","unstructured":"Parslew R, Friedmann PS (1999) The irritancy of anthralin is inhibited by repeat applications of a subirritant concentration. Br J Dermatol 141(3):469\u2013474. https:\/\/doi.org\/10.1046\/j.1365-2133.1999.03040.x","journal-title":"Br J Dermatol"},{"issue":"1","key":"2095_CR103","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1111\/j.1365-2133.2010.09757.x","volume":"163","author":"U Pereira","year":"2010","unstructured":"Pereira U, Boulais N, Lebonvallet N, Pennec JP, Dorange G, Misery L (2010) Mechanisms of the sensory effects of tacrolimus on the skin. Br J Dermatol 163(1):70\u201377. https:\/\/doi.org\/10.1111\/j.1365-2133.2010.09757.x","journal-title":"Br J Dermatol"},{"key":"2095_CR104","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.actbio.2024.05.021","volume":"182","author":"R Pepin","year":"2024","unstructured":"Pepin R, Ringuet J, Beaudet MJ, Bellenfant S, Galbraith T, Veillette H, Pouliot R, Berthod F (2024) Sensory neurons increase keratinocyte proliferation through CGRP release in a tissue engineered in vitro model of innervation in psoriasis. Acta Biomater 182:1\u201313. https:\/\/doi.org\/10.1016\/j.actbio.2024.05.021","journal-title":"Acta Biomater"},{"key":"2095_CR105","doi-asserted-by":"publisher","first-page":"242","DOI":"10.3389\/fimmu.2020.00242","volume":"11","author":"B Polese","year":"2020","unstructured":"Polese B, Zhang H, Thurairajah B, King IL (2020) Innate lymphocytes in psoriasis. Front Immunol 11:242. https:\/\/doi.org\/10.3389\/fimmu.2020.00242","journal-title":"Front Immunol"},{"issue":"2","key":"2095_CR106","doi-asserted-by":"publisher","first-page":"e79097","DOI":"10.7759\/cureus.79097","volume":"17","author":"SF Qasem","year":"2025","unstructured":"Qasem SF, Ashkanani H, Ali A (2025) Therapeutic advancements in the management of psoriasis: a clinical overview and update. Cureus 17(2):e79097. https:\/\/doi.org\/10.7759\/cureus.79097","journal-title":"Cureus"},{"issue":"4","key":"2095_CR107","doi-asserted-by":"publisher","first-page":"961","DOI":"10.2353\/ajpath.2008.070710","volume":"172","author":"SP Raychaudhuri","year":"2008","unstructured":"Raychaudhuri SP, Jiang WY, Raychaudhuri SK (2008) Revisiting the Koebner phenomenon: role of NGF and its receptor system in the pathogenesis of psoriasis. Am J Pathol 172(4):961\u2013971. https:\/\/doi.org\/10.2353\/ajpath.2008.070710","journal-title":"Am J Pathol"},{"issue":"8","key":"2095_CR108","doi-asserted-by":"publisher","first-page":"999","DOI":"10.1001\/archderm.136.8.999","volume":"136","author":"S Reitamo","year":"2000","unstructured":"Reitamo S, Wollenberg A, Sch\u00f6pf E, Perrot JL, Marks R, Ruzicka T, Christophers E, Kapp A, Lahfa M, Rubins A, Jablonska S, Rustin M (2000) Safety and efficacy of 1 year of tacrolimus ointment monotherapy in adults with atopic dermatitis. The European Tacrolimus Ointment Study Group. Arch Dermatol 136(8):999\u20131006. https:\/\/doi.org\/10.1001\/archderm.136.8.999","journal-title":"Arch Dermatol"},{"issue":"11","key":"2095_CR109","first-page":"1435","volume":"15","author":"MI Rendon","year":"2016","unstructured":"Rendon MI, Barkovic S (2016) Clinical evaluation of a 4% hydroquinone + 1% retinol treatment regimen for improving melasma and photodamage in Fitzpatrick skin types III\u2013VI. J Drugs Dermatol 15(11):1435\u20131441","journal-title":"J Drugs Dermatol"},{"issue":"6","key":"2095_CR110","doi-asserted-by":"publisher","first-page":"1475","DOI":"10.3390\/ijms20061475","volume":"20","author":"A Rendon","year":"2019","unstructured":"Rendon A, Sch\u00e4kel K (2019) Psoriasis pathogenesis and treatment. Int J Mol Sci 20(6):1475. https:\/\/doi.org\/10.3390\/ijms20061475","journal-title":"Int J Mol Sci"},{"issue":"7503","key":"2095_CR111","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1038\/nature13199","volume":"510","author":"L Riol-Blanco","year":"2014","unstructured":"Riol-Blanco L, Ordovas-Montanes J, Perro M, Naval E, Thiriot A, Alvarez D, Paust S, Wood JN, von Andrian UH (2014) Nociceptive sensory neurons drive interleukin-23-mediated psoriasiform skin inflammation. Nature 510(7503):157\u2013161. https:\/\/doi.org\/10.1038\/nature13199","journal-title":"Nature"},{"issue":"5","key":"2095_CR112","doi-asserted-by":"publisher","first-page":"542","DOI":"10.2340\/00015555-2047","volume":"95","author":"D Roblin","year":"2015","unstructured":"Roblin D, Yosipovitch G, Boyce B, Robinson J, Sandy J, Mainero V, Wickramasinghe R, Anand U, Anand P (2015) Topical TrkA kinase inhibitor CT327 is an effective, novel therapy for the treatment of pruritus due to psoriasis: results from experimental studies, and efficacy and safety of CT327 in a phase 2b clinical trial in patients with psoriasis. Acta Derm Venereol 95(5):542\u2013548. https:\/\/doi.org\/10.2340\/00015555-2047","journal-title":"Acta Derm Venereol"},{"issue":"3","key":"2095_CR113","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1038\/s41584-019-0175-0","volume":"15","author":"JU Scher","year":"2019","unstructured":"Scher JU, Ogdie A, Merola JF, Ritchlin C (2019) Preventing psoriatic arthritis: focusing on patients with psoriasis at increased risk of transition. Nat Rev Rheumatol 15(3):153\u2013166. https:\/\/doi.org\/10.1038\/s41584-019-0175-0","journal-title":"Nat Rev Rheumatol"},{"issue":"5","key":"2095_CR114","doi-asserted-by":"publisher","first-page":"S94","DOI":"10.1016\/j.jid.2016.02.572","volume":"136","author":"VE Scott","year":"2016","unstructured":"Scott VE, Patel H, Wetter J, Edlmayer R, Neelands T, Miller L, Huang S, Gauld S, Todorovic V, Gomtsian A, Dart M, Honore P, Kym P (2016) Defining a mechanistic link between TRPV3 activity and psoriasis through IL-1\u03b1 and EGFR signaling pathways. J Invest Dermatol 136(5):S94. https:\/\/doi.org\/10.1016\/j.jid.2016.02.572","journal-title":"J Invest Dermatol"},{"key":"2095_CR115","doi-asserted-by":"publisher","first-page":"110063","DOI":"10.1016\/j.intimp.2023.110063","volume":"118","author":"L Shang","year":"2023","unstructured":"Shang L, Zhao S, Shi H, Xing X, Zhang J, He Y (2023) Nerve growth factor mediates activation of transient receptor potential vanilloid 1 in neurogenic pruritus of psoriasis. Int Immunopharmacol 118:110063. https:\/\/doi.org\/10.1016\/j.intimp.2023.110063","journal-title":"Int Immunopharmacol"},{"issue":"2","key":"2095_CR116","doi-asserted-by":"publisher","first-page":"164","DOI":"10.1007\/s12016-024-08991-7","volume":"66","author":"I Sieminska","year":"2024","unstructured":"Sieminska I, Pieniawska M, Grzywa TM (2024) The immunology of psoriasis-current concepts in pathogenesis. Clin Rev Allergy Immunol 66(2):164\u2013191. https:\/\/doi.org\/10.1007\/s12016-024-08991-7","journal-title":"Clin Rev Allergy Immunol"},{"issue":"6","key":"2095_CR117","doi-asserted-by":"publisher","first-page":"1409","DOI":"10.1111\/jocd.13175","volume":"19","author":"J Srour","year":"2020","unstructured":"Srour J, Bengel J, Linden T, Jovanovic Z, Roggenkamp D, Reinholz M, Rothenberger C, Neufang G, Wollenberg A (2020) Efficacy of a skin care cream with TRPV1 inhibitor 4-t-butylcyclohexanol in the topical therapy of perioral dermatitis. J Cosmet Dermatol 19(6):1409\u20131414. https:\/\/doi.org\/10.1111\/jocd.13175","journal-title":"J Cosmet Dermatol"},{"issue":"2","key":"2095_CR118","doi-asserted-by":"publisher","first-page":"213","DOI":"10.2147\/tcrm.2006.2.2.213","volume":"2","author":"S St\u00e4nder","year":"2006","unstructured":"St\u00e4nder S, Sch\u00fcrmeyer-Horst F, Luger TA, Weisshaar E (2006) Treatment of pruritic diseases with topical calcineurin inhibitors. Ther Clin Risk Manag 2(2):213\u2013218. https:\/\/doi.org\/10.2147\/tcrm.2006.2.2.213","journal-title":"Ther Clin Risk Manag"},{"issue":"5","key":"2095_CR119","doi-asserted-by":"publisher","first-page":"1020","DOI":"10.1111\/j.1365-2133.2007.07813.x","volume":"156","author":"S St\u00e4nder","year":"2007","unstructured":"St\u00e4nder S, St\u00e4nder H, Seeliger S, Luger TA, Steinhoff M (2007) Topical pimecrolimus and tacrolimus transiently induce neuropeptide release and mast cell degranulation in murine skin. Br J Dermatol 156(5):1020\u20131026. https:\/\/doi.org\/10.1111\/j.1365-2133.2007.07813.x","journal-title":"Br J Dermatol"},{"issue":"1\u20132","key":"2095_CR120","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1016\/s0304-3959(03)00008-3","volume":"104","author":"RQ Sun","year":"2003","unstructured":"Sun RQ, Lawand NB, Willis WD (2003) The role of calcitonin gene-related peptide (CGRP) in the generation and maintenance of mechanical allodynia and hyperalgesia in rats after intradermal injection of capsaicin. Pain 104(1\u20132):201\u2013208. https:\/\/doi.org\/10.1016\/s0304-3959(03)00008-3","journal-title":"Pain"},{"issue":"1","key":"2095_CR121","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1159\/000068285","volume":"16","author":"OQ Swinkels","year":"2003","unstructured":"Swinkels OQ, Kucharekova M, Prins M, Gerritsen MJ, van der Valk PG, van de Kerkhof PC (2003) The effects of topical corticosteroids and a coal tar preparation on dithranol-induced irritation in patients with psoriasis. Skin Pharmacol Appl Skin Physiol 16(1):12\u201317. https:\/\/doi.org\/10.1159\/000068285","journal-title":"Skin Pharmacol Appl Skin Physiol"},{"issue":"2","key":"2095_CR122","doi-asserted-by":"publisher","first-page":"365","DOI":"10.1016\/j.jid.2017.07.852","volume":"138","author":"AG Sz\u00f6ll\u0151si","year":"2018","unstructured":"Sz\u00f6ll\u0151si AG, Vasas N, Angyal \u00c1, Kistam\u00e1s K, N\u00e1n\u00e1si PP, Mih\u00e1ly J, B\u00e9ke G, Herczeg-Lisztes E, Szegedi A, Kawada N, Yanagida T, Mori T, Kem\u00e9ny L, B\u00edr\u00f3 T (2018) Activation of TRPV3 regulates inflammatory actions of human epidermal keratinocytes. J Invest Dermatol 138(2):365\u2013374. https:\/\/doi.org\/10.1016\/j.jid.2017.07.852","journal-title":"J Invest Dermatol"},{"issue":"5","key":"2095_CR123","doi-asserted-by":"publisher","first-page":"222","DOI":"10.1111\/j.1600-0781.2008.00376.x","volume":"24","author":"YK Tandon","year":"2008","unstructured":"Tandon YK, Yang MF, Baron ED (2008) Role of photodynamic therapy in psoriasis: a brief review. Photodermatol Photoimmunol Photomed 24(5):222\u2013230. https:\/\/doi.org\/10.1111\/j.1600-0781.2008.00376.x","journal-title":"Photodermatol Photoimmunol Photomed"},{"issue":"6","key":"2095_CR124","doi-asserted-by":"publisher","first-page":"369","DOI":"10.2165\/0128071-200809060-00003","volume":"9","author":"A Thielitz","year":"2008","unstructured":"Thielitz A, Gollnick H (2008) Topical retinoids in acne vulgaris: update on efficacy and safety. Am J Clin Dermatol 9(6):369\u2013381. https:\/\/doi.org\/10.2165\/0128071-200809060-00003","journal-title":"Am J Clin Dermatol"},{"issue":"6","key":"2095_CR125","doi-asserted-by":"publisher","first-page":"856","DOI":"10.1111\/j.1365-2133.1994.tb08589.x","volume":"131","author":"HB Thio","year":"1994","unstructured":"Thio HB, Zomerdijk TP, Oudshoorn C, Kempenaar J, Nibbering PH, van der Schroeff JG, Ponec M (1994) Fumaric acid derivatives evoke a transient increase in intracellular free calcium concentration and inhibit the proliferation of human keratinocytes. Br J Dermatol 131(6):856\u2013861. https:\/\/doi.org\/10.1111\/j.1365-2133.1994.tb08589.x","journal-title":"Br J Dermatol"},{"issue":"10","key":"2095_CR126","doi-asserted-by":"publisher","first-page":"839","DOI":"10.1111\/j.1600-0625.2011.01318.x","volume":"20","author":"M Tsutsumi","year":"2011","unstructured":"Tsutsumi M, Kumamoto J, Denda M (2011) Intracellular calcium response to high temperature is similar in undifferentiated and differentiated cultured human keratinocytes. Exp Dermatol 20(10):839\u2013840. https:\/\/doi.org\/10.1111\/j.1600-0625.2011.01318.x","journal-title":"Exp Dermatol"},{"issue":"2","key":"2095_CR127","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1111\/1523-1747.ep12478077","volume":"95","author":"ML Turbitt","year":"1990","unstructured":"Turbitt ML, Akhurst RJ, White SI, MacKie RM (1990) Localization of elevated transforming growth factor-alpha in psoriatic epidermis. J Invest Dermatol 95(2):229\u2013232. https:\/\/doi.org\/10.1111\/1523-1747.ep12478077","journal-title":"J Invest Dermatol"},{"issue":"5","key":"2095_CR128","doi-asserted-by":"publisher","first-page":"556","DOI":"10.1016\/j.clindermatol.2016.05.005","volume":"34","author":"MM Valejo Coelho","year":"2016","unstructured":"Valejo Coelho MM, Apetato M (2016) The dark side of the light: phototherapy adverse effects. Clin Dermatol 34(5):556\u2013562. https:\/\/doi.org\/10.1016\/j.clindermatol.2016.05.005","journal-title":"Clin Dermatol"},{"issue":"4","key":"2095_CR129","doi-asserted-by":"publisher","first-page":"344","DOI":"10.1038\/ni.1851","volume":"11","author":"MR von Essen","year":"2010","unstructured":"von Essen MR, Kongsbak M, Schjerling P, Olgaard K, Odum N, Geisler C (2010) Vitamin D controls T cell antigen receptor signaling and activation of human T cells. Nat Immunol 11(4):344\u2013349. https:\/\/doi.org\/10.1038\/ni.1851","journal-title":"Nat Immunol"},{"issue":"3","key":"2095_CR130","doi-asserted-by":"publisher","first-page":"656","DOI":"10.1111\/bjd.15344","volume":"177","author":"B Wang","year":"2017","unstructured":"Wang B, Shi L, Zhang YF, Zhou Q, Zheng J, Szeimies RM, Wang XL (2017) Gain with no pain? Pain management in dermatological photodynamic therapy. Br J Dermatol 177(3):656\u2013665. https:\/\/doi.org\/10.1111\/bjd.15344","journal-title":"Br J Dermatol"},{"key":"2095_CR131","doi-asserted-by":"publisher","first-page":"115247","DOI":"10.1016\/j.taap.2020.115247","volume":"15","author":"W Wang","year":"2020","unstructured":"Wang W, Wang H, Zhao Z, Huang X, Xiong H, Mei Z (2020) Thymol activates TRPM8-mediated Ca2+ influx for its antipruritic effects and alleviates inflammatory response in Imiquimod-induced mice. Toxicol Appl Pharmacol 15:115247. https:\/\/doi.org\/10.1016\/j.taap.2020.115247","journal-title":"Toxicol Appl Pharmacol"},{"issue":"2","key":"2095_CR132","doi-asserted-by":"publisher","first-page":"313","DOI":"10.1007\/s10565-020-09536-2","volume":"37","author":"Y Wang","year":"2021","unstructured":"Wang Y, Li H, Xue C, Chen H, Xue Y, Zhao F, Zhu MX, Cao Z (2021) TRPV3 enhances skin keratinocyte proliferation through EGFR-dependent signaling pathways. Cell Biol Toxicol 37(2):313\u2013330. https:\/\/doi.org\/10.1007\/s10565-020-09536-2","journal-title":"Cell Biol Toxicol"},{"issue":"6","key":"2095_CR133","doi-asserted-by":"publisher","first-page":"1033","DOI":"10.1016\/j.jaad.2009.03.048","volume":"61","author":"CB Warren","year":"2009","unstructured":"Warren CB, Karai LJ, Vidimos A, Maytin EV (2009) Pain associated with aminolevulinic acid-photodynamic therapy of skin disease. J Am Acad Dermatol 61(6):1033\u20131043. https:\/\/doi.org\/10.1016\/j.jaad.2009.03.048","journal-title":"J Am Acad Dermatol"},{"issue":"2","key":"2095_CR134","doi-asserted-by":"publisher","first-page":"100177","DOI":"10.1016\/j.xjidi.2022.100177","volume":"3","author":"JJ Wheeler","year":"2022","unstructured":"Wheeler JJ, Domenichiello AF, Jensen JR, Keyes GS, Maiden KM, Davis JM, Ramsden CE, Mishra SK (2022) Endogenous derivatives of linoleic acid and their stable analogs are potential pain mediators. JID Innov 3(2):100177. https:\/\/doi.org\/10.1016\/j.xjidi.2022.100177","journal-title":"JID Innov"},{"issue":"10","key":"2095_CR135","doi-asserted-by":"publisher","first-page":"2081","DOI":"10.1007\/s00424-014-1666-0","volume":"467","author":"J Wie","year":"2015","unstructured":"Wie J, Kim J, Ha K, Zhang YH, Jeon JH, So I (2015) Dexamethasone activates transient receptor potential canonical 4 (TRPC4) channels via Rasd1 small GTPase pathway. Pflugers Arch 467(10):2081\u20132091. https:\/\/doi.org\/10.1007\/s00424-014-1666-0","journal-title":"Pflugers Arch"},{"key":"2095_CR136","unstructured":"World Intellectual Property Organization (2019) Global telehealth ecosystem and method of providing real-time medical examination and consultation services (Patente WO2019192239A1). Recuperado de https:\/\/patentscope.wipo.int\/search\/en\/WO2019192239"},{"issue":"2","key":"2095_CR137","doi-asserted-by":"publisher","first-page":"284","DOI":"10.1097\/j.pain.0000000000001096","volume":"159","author":"L Wright","year":"2018","unstructured":"Wright L, Baptista-Hon D, Bull F, Dalgaty F, Gallacher M, Ibbotson SH, Hales TG (2018) Menthol reduces phototoxicity pain in a mouse model of photodynamic therapy. Pain 159(2):284\u2013297. https:\/\/doi.org\/10.1097\/j.pain.0000000000001096","journal-title":"Pain"},{"key":"2095_CR138","doi-asserted-by":"publisher","first-page":"1037925","DOI":"10.3389\/fphar.2023.1037925","volume":"15","author":"T Xiao","year":"2023","unstructured":"Xiao T, Sun M, Zhao C, Kang J (2023) TRPV1: a promising therapeutic target for skin aging and inflammatory skin diseases. Front Pharmacol 15:1037925. https:\/\/doi.org\/10.3389\/fphar.2023.1037925","journal-title":"Front Pharmacol"},{"key":"2095_CR139","doi-asserted-by":"publisher","first-page":"1025499","DOI":"10.3389\/fimmu.2022.1025499","volume":"20","author":"D Yamada","year":"2022","unstructured":"Yamada D, Vu S, Wu X, Shi Z, Morris D, Bloomstein JD, Huynh M, Zheng J, Hwang ST (2022) Gain-of-function of TRPM4 predisposes mice to psoriasiform dermatitis. Front Immunol 20:1025499. https:\/\/doi.org\/10.3389\/fimmu.2022.1025499","journal-title":"Front Immunol"},{"issue":"1","key":"2095_CR140","doi-asserted-by":"publisher","first-page":"361","DOI":"10.1159\/000430360","volume":"37","author":"H Yang","year":"2015","unstructured":"Yang H, Xiong J, Luo W, Yang J, Xi T (2015) 8-methoxypsoralen induces intrinsic apoptosis in HepG2 cells: involvement of reactive oxygen species generation and ERK1\/2 pathway inhibition. Cell Physiol Biochem 37(1):361\u2013374. https:\/\/doi.org\/10.1159\/000430360","journal-title":"Cell Physiol Biochem"},{"issue":"9","key":"2095_CR141","doi-asserted-by":"publisher","first-page":"3941","DOI":"10.1172\/JCI66413","volume":"123","author":"S Yin","year":"2013","unstructured":"Yin S, Luo J, Qian A, Du J, Yang Q, Zhou S, Yu W, Du G, Clark RB, Walters ET, Carlton SM, Hu H (2013) Retinoids activate the irritant receptor TRPV1 and produce sensory hypersensitivity. J Clin Invest 123(9):3941\u20133951. https:\/\/doi.org\/10.1172\/JCI66413","journal-title":"J Clin Invest"},{"issue":"8","key":"2095_CR142","doi-asserted-by":"publisher","first-page":"2173","DOI":"10.1016\/j.jid.2022.01.002","volume":"142","author":"Q Yin","year":"2022","unstructured":"Yin Q, Sun L, Cai X, Lou F, Sun Y, Wang B, Jiang B, Bao L, Li X, Song N, Tang S, Bai J, Wang Z, Wu Y, Zhou H, Wang H, Yu B, Li Q, Wang H (2022) Lidocaine ameliorates psoriasis by obstructing pathogenic CGRP signaling-mediated sensory neuron-dendritic cell communication. J Invest Dermatol 142(8):2173-2183.e6. https:\/\/doi.org\/10.1016\/j.jid.2022.01.002","journal-title":"J Invest Dermatol"},{"issue":"7","key":"2095_CR143","doi-asserted-by":"publisher","first-page":"836","DOI":"10.1001\/archderm.142.7.836","volume":"142","author":"SS Yones","year":"2006","unstructured":"Yones SS, Palmer RA, Garibaldinos TT, Hawk JL (2006) Randomized double-blind trial of the treatment of chronic plaque psoriasis: efficacy of psoralen-UV-A therapy vs narrowband UV-B therapy. Arch Dermatol 142(7):836\u2013842. https:\/\/doi.org\/10.1001\/archderm.142.7.836","journal-title":"Arch Dermatol"},{"key":"2095_CR144","doi-asserted-by":"publisher","first-page":"821874","DOI":"10.5402\/2011\/821874","volume":"2011","author":"CS Yu","year":"2011","unstructured":"Yu CS (2011) Study on HIF-1\u03b1 gene translation in psoriatic epidermis with the topical treatment of capsaicin ointment. ISRN Pharm 2011:821874. https:\/\/doi.org\/10.5402\/2011\/821874","journal-title":"ISRN Pharm"},{"issue":"2 Suppl","key":"2095_CR145","doi-asserted-by":"publisher","first-page":"S78","DOI":"10.1016\/s0190-9622(03)01139-3","volume":"49","author":"M Zanolli","year":"2003","unstructured":"Zanolli M (2003) Phototherapy treatment of psoriasis today. J Am Acad Dermatol 49(2 Suppl):S78\u2013S86. https:\/\/doi.org\/10.1016\/s0190-9622(03)01139-3","journal-title":"J Am Acad Dermatol"},{"issue":"4","key":"2095_CR146","doi-asserted-by":"publisher","first-page":"392","DOI":"10.5114\/ada.2019.87443","volume":"36","author":"M Zasada","year":"2019","unstructured":"Zasada M, Budzisz E (2019) Retinoids: active molecules influencing skin structure formation in cosmetic and dermatological treatments. Postepy Dermatol Alergol 36(4):392\u2013397. https:\/\/doi.org\/10.5114\/ada.2019.87443","journal-title":"Postepy Dermatol Alergol"},{"issue":"1","key":"2095_CR147","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1038\/s41392-023-01464-x","volume":"8","author":"M Zhang","year":"2023","unstructured":"Zhang M, Ma Y, Ye X, Zhang N, Pan L, Wang B (2023) TRP (transient receptor potential) ion channel family: structures, biological functions and therapeutic interventions for diseases. Signal Transduct Target Ther 8(1):261. https:\/\/doi.org\/10.1038\/s41392-023-01464-x","journal-title":"Signal Transduct Target Ther"},{"key":"2095_CR148","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2025.03.037","author":"Q Zhang","year":"2025","unstructured":"Zhang Q, Jang M, Dias FC, Zeng Q, Wang P, Tai H, Chattha E, Zhang JY, Lim RSP, Liedtke W, Chen Y (2025) Neuronal mechanisms of psoriatic itch: role of IL-17R\/ERK\/TRPV4 signaling pathway. J Invest Dermatol. https:\/\/doi.org\/10.1016\/j.jid.2025.03.037","journal-title":"J Invest Dermatol"},{"issue":"3","key":"2095_CR149","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1007\/s40257-016-0183-7","volume":"17","author":"TH Zhu","year":"2016","unstructured":"Zhu TH, Nakamura M, Farahnik B, Abrouk M, Lee K, Singh R, Gevorgyan A, Koo J, Bhutani T (2016) The role of the nervous system in the pathophysiology of psoriasis: a review of cases of psoriasis remission or improvement following denervation injury. Am J Clin Dermatol 17(3):257\u2013263. https:\/\/doi.org\/10.1007\/s40257-016-0183-7","journal-title":"Am J Clin Dermatol"},{"issue":"3","key":"2095_CR150","doi-asserted-by":"publisher","first-page":"264","DOI":"10.1016\/j.jdermsci.2018.11.009","volume":"92","author":"Y Zhou","year":"2018","unstructured":"Zhou Y, Follansbee T, Wu X, Han D, Yu S, Domocos DT, Shi Z, Carstens M, Carstens E, Hwang ST (2018) TRPV1 mediates inflammation and hyperplasia in imiquimod (IMQ)-induced psoriasiform dermatitis (PsD) in mice. J Dermatol Sci 92(3):264\u2013271. https:\/\/doi.org\/10.1016\/j.jdermsci.2018.11.009","journal-title":"J Dermatol Sci"},{"issue":"7","key":"2095_CR151","doi-asserted-by":"publisher","first-page":"4819","DOI":"10.1111\/jcmm.14392","volume":"23","author":"Y Zhou","year":"2019","unstructured":"Zhou Y, Han D, Follansbee T, Wu X, Yu S, Wang B, Shi Z, Domocos DT, Carstens M, Carstens E, Hwang ST (2019) Transient receptor potential ankyrin 1 (TRPA1) positively regulates imiquimod-induced, psoriasiform dermal inflammation in mice. J Cell Mol Med 23(7):4819\u20134828. https:\/\/doi.org\/10.1111\/jcmm.14392","journal-title":"J Cell Mol Med"}],"container-title":["Inflammopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10787-025-02095-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10787-025-02095-0","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10787-025-02095-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T20:01:55Z","timestamp":1773777715000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10787-025-02095-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,14]]},"references-count":151,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,3]]}},"alternative-id":["2095"],"URL":"https:\/\/doi.org\/10.1007\/s10787-025-02095-0","relation":{},"ISSN":["0925-4692","1568-5608"],"issn-type":[{"value":"0925-4692","type":"print"},{"value":"1568-5608","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2,14]]},"assertion":[{"value":"10 July 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 December 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 February 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}}]}}