{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,21]],"date-time":"2026-02-21T02:03:30Z","timestamp":1771639410639,"version":"3.50.1"},"reference-count":25,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2026,1,31]],"date-time":"2026-01-31T00:00:00Z","timestamp":1769817600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,1,31]],"date-time":"2026-01-31T00:00:00Z","timestamp":1769817600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Inflammopharmacol"],"published-print":{"date-parts":[[2026,2]]},"DOI":"10.1007\/s10787-025-02097-y","type":"journal-article","created":{"date-parts":[[2026,1,31]],"date-time":"2026-01-31T06:48:24Z","timestamp":1769842104000},"page":"1267-1275","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Montelukast alleviates levels of inflammatory factors and chemokines in patients with allergic rhinitis"],"prefix":"10.1007","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-4852-3497","authenticated-orcid":false,"given":"Bo","family":"Ru","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenbo","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2026,1,31]]},"reference":[{"issue":"4","key":"2097_CR1","doi-asserted-by":"publisher","first-page":"e37060","DOI":"10.1097\/MD.0000000000037060","volume":"103","author":"J Ai","year":"2024","unstructured":"Ai J, Guo S, Wang Y et al (2024) Fire needle acupuncture at Neiyingxiang (EX-HN 9) in the treatment of moderate and severe refractory perennial allergic rhinitis: a case report. Med (Baltim) 103(4):e37060 https:\/\/doi.org\/10.1097\/MD.0000000000037060","journal-title":"Med (Baltim)"},{"key":"2097_CR2","doi-asserted-by":"publisher","first-page":"983621","DOI":"10.3389\/fimmu.2022.983621","volume":"13","author":"M Babayeva","year":"2022","unstructured":"Babayeva M, Tabynov K, Nurpeisov T et al (2022) A Recombinant Artemisia vulgarispollen adjuvanted Art v 1 protein-based vaccine treats allergic rhinitis and bronchial asthma using pre- and co-seasonal ultrashort immunotherapy regimens in sensitized mice. Front Immunol 13:983621. https:\/\/doi.org\/10.3389\/fimmu.2022.983621","journal-title":"Front Immunol"},{"key":"2097_CR3","doi-asserted-by":"publisher","first-page":"1805","DOI":"10.2147\/JAA.S395490","volume":"15","author":"Y Bao","year":"2022","unstructured":"Bao Y, Zhu X (2022) Role of chemokines and inflammatory cells in respiratory allergy. J Asthma Allergy 15:1805\u20131822. https:\/\/doi.org\/10.2147\/JAA.S395490","journal-title":"J Asthma Allergy"},{"issue":"2","key":"2097_CR4","doi-asserted-by":"publisher","first-page":"152","DOI":"10.1007\/s12070-020-01907-9","volume":"73","author":"B Bhardwaj","year":"2021","unstructured":"Bhardwaj B, Singh J (2021) Efficacy of vitamin D supplementation in allergic rhinitis. Indian J Otolaryngol Head Neck Surg 73(2):152\u2013159. https:\/\/doi.org\/10.1007\/s12070-020-01907-9","journal-title":"Indian J Otolaryngol Head Neck Surg"},{"key":"2097_CR5","doi-asserted-by":"publisher","first-page":"e081124","DOI":"10.1136\/bmj-2024-081124","volume":"389","author":"S Hopewell","year":"2025","unstructured":"Hopewell S, Chan AW, Collins GS et al (2025) CONSORT 2025 explanation and elaboration: updated guideline for reporting randomised trials. BMJ 389:e081124 https:\/\/doi.org\/10.1136\/bmj-2024-081124","journal-title":"BMJ"},{"key":"2097_CR6","doi-asserted-by":"publisher","first-page":"804109","DOI":"10.3389\/fmolb.2022.804109","volume":"9","author":"P Hosseini","year":"2022","unstructured":"Hosseini P, Fallahi MS, Erabi G et al (2022) Multisystem inflammatory syndrome and autoimmune diseases following COVID-19: molecular mechanisms and therapeutic opportunities. Front Mol Biosci 9:804109. https:\/\/doi.org\/10.3389\/fmolb.2022.804109","journal-title":"Front Mol Biosci"},{"issue":"6","key":"2097_CR7","doi-asserted-by":"publisher","first-page":"652","DOI":"10.4168\/aair.2024.16.6.652","volume":"16","author":"CK Kim","year":"2024","unstructured":"Kim CK, Hwang Y, Song DJ et al (2024a) Efficacy and safety of Montelukast\u2009+\u2009Levocetirizine combination therapy compared to Montelukast monotherapy for allergic rhinitis in children. Allergy Asthma Immunol Res 16(6):652\u2013667. https:\/\/doi.org\/10.4168\/aair.2024.16.6.652","journal-title":"Allergy Asthma Immunol Res"},{"issue":"1","key":"2097_CR8","doi-asserted-by":"publisher","first-page":"e002483","DOI":"10.1136\/bmjpo-2023-002483","volume":"8","author":"JW Kim","year":"2024","unstructured":"Kim JW, Kim M, Seo MS, Shin JY (2024b) Risk of neuropsychiatric adverse events associated with Montelukast use in children and adolescents: a population-based case-crossover study. BMJ Paediatr Open 8(1):e002483. https:\/\/doi.org\/10.1136\/bmjpo-2023-002483","journal-title":"BMJ Paediatr Open"},{"key":"2097_CR9","doi-asserted-by":"publisher","unstructured":"Krishnamoorthy M, Mohd Noor N, Mat Lazim N, Abdullah B (2020) Efficacy of montelukast in allergic rhinitis treatment: a systematic review and meta-analysis. Drugs 80(17):1831\u20131851. https:\/\/doi.org\/10.1007\/s40265-020-01406-9","DOI":"10.1007\/s40265-020-01406-9"},{"issue":"12","key":"2097_CR10","doi-asserted-by":"publisher","first-page":"1611","DOI":"10.1080\/02770903.2024.2370002","volume":"61","author":"YJ Lee","year":"2024","unstructured":"Lee YJ, Ma HS, Callaway Z, Kim CK (2024) Montelukast treatment response according to eosinophil-derived neurotoxin level in children with allergic rhinitis. J Asthma 61(12):1611\u20131618. https:\/\/doi.org\/10.1080\/02770903.2024.2370002","journal-title":"J Asthma"},{"key":"2097_CR12","doi-asserted-by":"crossref","unstructured":"Li Y, Bonner MR, Browne RW, Deng F et al (2019) Responses of serum chemokines to dramatic changes of air pollution levels, a panel study, Biomarkers 28:712\u2013719. 10.1080\/1354750X.2019.1658803","DOI":"10.1080\/1354750X.2019.1658803"},{"issue":"11","key":"2097_CR13","doi-asserted-by":"publisher","first-page":"845","DOI":"10.1007\/s11655-020-3099-2","volume":"26","author":"YJ Li","year":"2020","unstructured":"Li YJ, Zong M, Ding LF et al (2020) Efficacy of Chinese medicine acupoint application combined with Montelukast on children with perennial allergic rhinitis: a randomized controlled trial. Chin J Integr Med 26(11):845\u2013852. https:\/\/doi.org\/10.1007\/s11655-020-3099-2","journal-title":"Chin J Integr Med"},{"issue":"2","key":"2097_CR11","doi-asserted-by":"publisher","first-page":"93","DOI":"10.4149\/gpb_2024045","volume":"44","author":"L Li","year":"2025","unstructured":"Li L, Zhang Y, Wang J, Zhang L et al (2025) GZMA Silencing inhibits JAK2\/STAT1 pathway and improves allergic rhinitis. Gen Physiol Biophys 44(2):93\u2013106. https:\/\/doi.org\/10.4149\/gpb_2024045","journal-title":"Gen PhysiolBiophys"},{"issue":"2","key":"2097_CR14","doi-asserted-by":"publisher","first-page":"340","DOI":"10.1111\/fcp.12847","volume":"37","author":"Y Ma","year":"2023","unstructured":"Ma Y, Yang XH, Tu Y, Athari SS (2023) Survey the effect of drug treatment on modulation of cytokines gene expression in allergic rhinitis. Fundam Clin Pharmacol 37(2):340\u2013346. https:\/\/doi.org\/10.1111\/fcp.12847","journal-title":"Fundam Clin Pharmacol"},{"issue":"5","key":"2097_CR15","doi-asserted-by":"publisher","first-page":"1350","DOI":"10.12669\/pjms.39.5.6985","volume":"39","author":"X Mao","year":"2023","unstructured":"Mao X, Zhao W (2023) Efficacy of Montelukast combined with Sublingual immunotherapy in the treatment of children with obstructive sleep apnea hypopnea syndrome complicated with allergic rhinitis. Pak J Med Sci 39(5):1350\u20131354. https:\/\/doi.org\/10.12669\/pjms.39.5.6985","journal-title":"Pak J Med Sci"},{"issue":"14","key":"2097_CR16","doi-asserted-by":"publisher","first-page":"3191","DOI":"10.3390\/nu15143191","volume":"15","author":"D Moriki","year":"2023","unstructured":"Moriki D, Antonogeorgos G, Koumpagioti D et al (2023) Adherence to an Anti-Inflammatory diet and atopic diseases\u2019 prevalence in adolescence: the Greek global asthma network study. Nutrients 15(14):3191. https:\/\/doi.org\/10.3390\/nu15143191","journal-title":"Nutrients"},{"key":"2097_CR17","doi-asserted-by":"publisher","unstructured":"Nur Husna SM, Md Shukri N, Mohd Ashari NS, Wong KK (2022) IL-4\/IL-13 axis as therapeutic targets in allergic rhinitis and asthma. PeerJ 10: e13444. https:\/\/doi.org\/10.7717\/peerj.13444","DOI":"10.7717\/peerj.13444"},{"key":"2097_CR18","doi-asserted-by":"publisher","unstructured":"Ono T, Morimoto T, Hanakita T, Watanabe K, Iwamura C, Asakura N (2025) Performance of a point of care allergy test compared to an established laboratory test for specific IgE in Japanese patients with allergic rhinitis. J Immunoass Immunochem. https:\/\/doi.org\/10.1080\/15321819.2025.2490541","DOI":"10.1080\/15321819.2025.2490541"},{"key":"2097_CR19","doi-asserted-by":"publisher","first-page":"117428","DOI":"10.1016\/j.jep.2023.117428","volume":"320","author":"L Ou","year":"2024","unstructured":"Ou L, Liu HR, Shi XY et al (2024) Terminalia chebula Retz. Aqueous extract inhibits the Helicobacter pylori-induced inflammatory response by regulating the inflammasome signaling and ER-stress pathway. J Ethnopharmacol 320:117428. https:\/\/doi.org\/10.1016\/j.jep.2023.117428","journal-title":"J Ethnopharmacol"},{"key":"2097_CR20","doi-asserted-by":"publisher","unstructured":"Subspecialty Group of Rhinology, Editorial Board of Chinese Journal of Otorhinolaryngology Head and Neck Surgery; Subspecialty Group of Rhinology, Society of Otorhinolaryngology Head and Neck Surgery, Chinese Medical Association (2022) Chinese guideline for diagnosis and treatment of allergic rhinitis (2022, revision).Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 57(2):106\u2013129. https:\/\/doi.org\/10.3760\/cma.j.cn115330-20211228-00828","DOI":"10.3760\/cma.j.cn115330-20211228-00828"},{"issue":"6","key":"2097_CR21","doi-asserted-by":"publisher","first-page":"730","DOI":"10.1177\/19458924231191012","volume":"37","author":"H Wang","year":"2023","unstructured":"Wang H, Wu J, Zhang R (2023) Effect of Neurokinin-1 receptor knockdown on the expression of RANTES in allergic rhinitis. Am J Rhinol Allergy 37(6):730\u2013738. https:\/\/doi.org\/10.1177\/19458924231191012","journal-title":"Am J Rhinol Allergy"},{"issue":"1","key":"2097_CR22","doi-asserted-by":"publisher","first-page":"7236","DOI":"10.1038\/s41598-022-11398-z","volume":"12","author":"CT Wu","year":"2022","unstructured":"Wu CT, Tsao CH, Chen KT, Lee YT, Ku MS (2022) Allergic rhinitis is associated with thromboembolic disease in pregnancy. Sci Rep 12(1):7236. https:\/\/doi.org\/10.1038\/s41598-022-11398-z","journal-title":"Sci Rep"},{"issue":"1","key":"2097_CR23","doi-asserted-by":"publisher","first-page":"2308077","DOI":"10.1080\/07853890.2024.2308077","volume":"56","author":"A Zhao","year":"2024","unstructured":"Zhao A, Sun Q, Zhang J et al (2024) Substance basis and Pharmacological mechanism of heat-clearing herbs in the treatment of ischaemic encephalopathy: a systematic review and network Pharmacology. Ann Med 56(1):2308077. https:\/\/doi.org\/10.1080\/07853890.2024.2308077","journal-title":"Ann Med"},{"issue":"1","key":"2097_CR24","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1186\/s13643-024-02748-1","volume":"14","author":"W Zhao","year":"2025","unstructured":"Zhao W, Kong L, Wang X et al (2025) Efficacy and safety of Chinese patent medicines for allergic rhinitis based on 2020 Chinese pharmacopoeia: a protocol for systematic review and meta-analysis of randomized controlled trials. Syst Rev 14(1):69. https:\/\/doi.org\/10.1186\/s13643-024-02748-1","journal-title":"Syst Rev"},{"issue":"5","key":"2097_CR25","doi-asserted-by":"publisher","first-page":"881","DOI":"10.1080\/02770903.2024.2449231","volume":"62","author":"X Zhu","year":"2025","unstructured":"Zhu X, Lv Q (2025) Association and mechanism of Montelukast on sleep disorders: insights from NHANES 2005\u20132018 data analysis and a network Pharmacology study. J Asthma 62(5):881\u2013890. https:\/\/doi.org\/10.1080\/02770903.2024.2449231","journal-title":"J Asthma"}],"container-title":["Inflammopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10787-025-02097-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10787-025-02097-y","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10787-025-02097-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,21]],"date-time":"2026-02-21T01:12:38Z","timestamp":1771636358000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10787-025-02097-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,31]]},"references-count":25,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,2]]}},"alternative-id":["2097"],"URL":"https:\/\/doi.org\/10.1007\/s10787-025-02097-y","relation":{},"ISSN":["0925-4692","1568-5608"],"issn-type":[{"value":"0925-4692","type":"print"},{"value":"1568-5608","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1,31]]},"assertion":[{"value":"21 May 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 December 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"31 January 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors have no relevant financial or non-financial interests to disclose.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"Th\n                      e\n                      study was approved by the local ethics committee of the Baihe Branch of Yinzhou People\u2019s Hospital (Approval number: BBYPH032), all experiments were performed in accordance with relevant guidelines and regulations such as the Declaration of Helsinki.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"Informed consents were obtained from all participants included in the study.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}},{"value":"Not applicable and no personal data for any participant are included.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to publish"}}]}}