{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,21]],"date-time":"2026-02-21T02:03:19Z","timestamp":1771639399846,"version":"3.50.1"},"reference-count":61,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2026,1,5]],"date-time":"2026-01-05T00:00:00Z","timestamp":1767571200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,1,5]],"date-time":"2026-01-05T00:00:00Z","timestamp":1767571200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100002322","name":"CAPES","doi-asserted-by":"crossref","award":["2833-2011"],"award-info":[{"award-number":["2833-2011"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100003593","name":"CNPq","doi-asserted-by":"crossref","award":["309054\/2016-8"],"award-info":[{"award-number":["309054\/2016-8"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"crossref"}]},{"name":"UFSJ\/postgraduate fellowship"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Inflammopharmacol"],"published-print":{"date-parts":[[2026,2]]},"DOI":"10.1007\/s10787-025-02098-x","type":"journal-article","created":{"date-parts":[[2026,1,5]],"date-time":"2026-01-05T05:41:54Z","timestamp":1767591714000},"page":"1251-1265","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Alkaloid fraction of Duguetia furfuracea demonstrated anti-inflammatory and antinociceptive effects through decrease of tumour necrosis factor alpha in mice models"],"prefix":"10.1007","volume":"34","author":[{"given":"Jo\u00e3o Paulo Costa","family":"Rodrigues","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fellipe Alexandre Alves","family":"Moraes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fl\u00e1vio Martins","family":"de Oliveira","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D\u00e9bora","family":"de Oliveira Lopes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fl\u00e1via Carmo Horta","family":"Pinto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aline Aparecida","family":"Saldanha","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arthur Ladeira","family":"Macedo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlos Alexandre","family":"Carollo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jo\u00e3o M\u00e1ximo","family":"de Siqueira","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adriana Cristina","family":"Soares","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2026,1,5]]},"reference":[{"key":"2098_CR1","doi-asserted-by":"publisher","first-page":"6611","DOI":"10.1007\/s11033-020-05712-z","volume":"47","author":"MA Alblihed","year":"2020","unstructured":"Alblihed MA (2020) Astragalin attenuates oxidative stress and acute inflammatory responses in carrageenan-induced paw oedema in mice. Mol Biol Rep 47:6611\u20136620. https:\/\/doi.org\/10.1007\/s11033-020-05712-z","journal-title":"Mol Biol Rep"},{"key":"2098_CR2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20225635","volume":"20","author":"RS Almeer","year":"2019","unstructured":"Almeer RS, Hammad SF, Leheta OF et al (2019) Anti-inflammatory and anti-hyperuricemic functions of two synthetic hybrid drugs with dual biological active sites. Int J Mol Sci 20:5635. https:\/\/doi.org\/10.3390\/ijms20225635","journal-title":"Int J Mol Sci"},{"key":"2098_CR3","doi-asserted-by":"publisher","first-page":"4","DOI":"10.4172\/2161-1459.1000240","volume":"7","author":"A Alsousi","year":"2017","unstructured":"Alsousi A, Siddiqui S, Igwe O (2017) Cytokine-mediated diferential regulation of cyclooxygenase-2, high mobility group box 1 protein and matrix metalloproteinase-9 expression in fbroblast-like synovial cells. J Clin Exp Pharmacol 7:4. https:\/\/doi.org\/10.4172\/2161-1459.1000240","journal-title":"J Clin Exp Pharmacol"},{"key":"2098_CR4","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2021.113165","volume":"213","author":"R Bai","year":"2021","unstructured":"Bai R, Yao C, Zhong Z et al (2021) Discovery of natural anti-inflammatory alkaloids: potential leads for the drug discovery for the treatment of inflammation. Eur J Med Chem 213:113165. https:\/\/doi.org\/10.1016\/j.ejmech.2021.113165","journal-title":"Eur J Med Chem"},{"key":"2098_CR5","doi-asserted-by":"publisher","first-page":"309","DOI":"10.1016\/j.biopha.2018.09.004","volume":"108","author":"Y Bao","year":"2018","unstructured":"Bao Y, Li H, Li QY et al (2018) Therapeutic efects of Smilax glabra and Bolbostemma paniculatum on rheumatoid arthritis using a rat paw edema model. Biomed Pharmacother 108:309\u2013315. https:\/\/doi.org\/10.1016\/j.biopha.2018.09.004","journal-title":"Biomed Pharmacother"},{"key":"2098_CR6","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1016\/j.cell.2009.09.028","volume":"139","author":"AI Basbaum","year":"2009","unstructured":"Basbaum AI, Bautista DM, Scherrer G et al (2009) Cellular and molecular mechanisms of pain. Cell 139:267\u2013284. https:\/\/doi.org\/10.1016\/j.cell.2009.09.028","journal-title":"Cell"},{"key":"2098_CR7","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1002\/path.2287","volume":"214","author":"JR Bradley","year":"2008","unstructured":"Bradley JR (2008) TNF-mediated inflammatory disease. J Pathol 214:149\u2013160. https:\/\/doi.org\/10.1002\/path.2287","journal-title":"J Pathol"},{"key":"2098_CR8","doi-asserted-by":"publisher","first-page":"1222","DOI":"10.1021\/np0600191","volume":"69","author":"CA Carollo","year":"2006","unstructured":"Carollo CA, Siqueira JM, Garcez WS et al (2006a) N-Nitrosoanonaine and N-Nitrosoxylopine, aporphine alkaloids from Duguetia furfuracea. J Nat Prod 69:1222\u20131224. https:\/\/doi.org\/10.1021\/np0600191","journal-title":"J Nat Prod"},{"key":"2098_CR9","doi-asserted-by":"publisher","first-page":"837","DOI":"10.4067\/S0717-97072006000200001","volume":"51","author":"CA Carollo","year":"2006","unstructured":"Carollo CA, Hellmann-Carollo AR, Siqueira JM et al (2006b) Alkaloids and a flavonoid from aerial parts (leaves and twigs) of Duguetia furfuracea - Annonaceae. J Chil Chem Soc 51:837\u2013841. https:\/\/doi.org\/10.4067\/S0717-97072006000200001","journal-title":"J Chil Chem Soc"},{"key":"2098_CR10","doi-asserted-by":"publisher","first-page":"274","DOI":"10.1016\/s0899-9007(96)00000-8","volume":"12","author":"EM Conner","year":"1996","unstructured":"Conner EM, Grisham MB (1996) Inflammation, free radicals, and antioxidants. Nutrition 12:274\u2013277. https:\/\/doi.org\/10.1016\/s0899-9007(96)00000-8","journal-title":"Nutrition"},{"key":"2098_CR11","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1111\/j.1476-5381.1993.tb13791.x","volume":"110","author":"CR Corr\u00eaa","year":"1993","unstructured":"Corr\u00eaa CR, Calixto JB (1993) Evidence for participation of B1 and B2 kinin receptors in formalin-induced nociceptive response in the mouse. Br J Pharmacol 110:193\u2013198. https:\/\/doi.org\/10.1111\/j.1476-5381.1993.tb13791.x","journal-title":"Br J Pharmacol"},{"key":"2098_CR12","unstructured":"da Silva Coelho L (2003) Medicinal plant based renal colic treatment agent consists of 250 milligramme capsules based on Duguetia furfuracea material. Dervewent Innovations Index Br20022030-A"},{"key":"2098_CR13","doi-asserted-by":"publisher","first-page":"6969","DOI":"10.1021\/jf061090f","volume":"54","author":"NE Es-Safi","year":"2006","unstructured":"Es-Safi NE, Guyot S, Ducrot PH (2006) NMR, ESI\/MS, and MALDI-TOF\/MS analysis of pear juice polymeric proanthocyanidins with potent free radical scavenging activity. J Agric Food Chem 54:6969\u20136977. https:\/\/doi.org\/10.1021\/jf061090f","journal-title":"J Agric Food Chem"},{"key":"2098_CR14","doi-asserted-by":"publisher","first-page":"162","DOI":"10.1016\/S0891-5849(97)00280-3","volume":"13","author":"TS Fr\u00f6de","year":"2001","unstructured":"Fr\u00f6de TS, Souza GEP, Calixto JB (2001) The modulatory role played by TNF-\u03b1 and IL-1\u03b2 in the inflammatory responses induced by carrageenan in the mouse model of pleurisy. Cytokine 13:162\u2013168. https:\/\/doi.org\/10.1016\/S0891-5849(97)00280-3","journal-title":"Cytokine"},{"key":"2098_CR15","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1016\/0165-0270(85)90116-5","volume":"14","author":"S Hunskaar","year":"1985","unstructured":"Hunskaar S, Fasmer OB, Hole K (1985) Formalin test in mice, a useful technique for evaluating mild analgesics. J Neurosci Methods 14:69\u201376. https:\/\/doi.org\/10.1016\/0165-0270(85)90116-5","journal-title":"J Neurosci Methods"},{"key":"2098_CR16","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1016\/0304-3959(87)90088-1","volume":"30","author":"S Hunskaar","year":"1987","unstructured":"Hunskaar S, Hole K (1987) The formalin test in mice: dissociation between inflammatory and non-inflammatory pain. Pain 30:103\u2013114. https:\/\/doi.org\/10.1016\/0304-3959(87)90088-1","journal-title":"Pain"},{"key":"2098_CR17","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1016\/j.neuropharm.2015.04.037","volume":"97","author":"B-W Kim","year":"2015","unstructured":"Kim B-W, Koppula S, Kumar H et al (2015) \u03b1-Asarone attenuates microglia-mediated neuroinflammation by inhibiting NF kappa B activation and mitigates MPTPinduced behavioral deficits in a mouse model of Parkinson\u2019s disease. Neuropharmacol 97:46\u201357. https:\/\/doi.org\/10.1016\/j.neuropharm.2015.04.037","journal-title":"Neuropharmacol"},{"key":"2098_CR18","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1038\/nri3399","volume":"13","author":"E Kolaczkowska","year":"2013","unstructured":"Kolaczkowska E, Kubes P (2013) Neutrophil recruitment and function in health and infammation. Nat Rev Immunol 13:159\u2013175. https:\/\/doi.org\/10.1038\/nri3399","journal-title":"Nat Rev Immunol"},{"key":"2098_CR19","first-page":"412","volume":"18","author":"R Koster","year":"1959","unstructured":"Koster R, Anderson M, Beer EJ (1959) Acetic acid for analgesic screening. Fed Proc 18:412\u2013418","journal-title":"Fed Proc"},{"key":"2098_CR20","doi-asserted-by":"publisher","first-page":"1423","DOI":"10.1189\/jlb.0607421","volume":"83","author":"M Lauterbach","year":"2008","unstructured":"Lauterbach M, O\u2019Donnell P, Asano K et al (2008) Role of TNF priming and adhesion molecules in neutrophil recruitment to intravascular immune complexes. J Leukoc Biol 83:1423\u20131430. https:\/\/doi.org\/10.1189\/jlb.0607421","journal-title":"J Leukoc Biol"},{"key":"2098_CR21","doi-asserted-by":"publisher","first-page":"1715","DOI":"10.1016\/j.intimp.2011.06.003","volume":"11","author":"CS Lee","year":"2011","unstructured":"Lee CS, Lee SA, Kim YJ et al (2011) 3,4,5-tricaffeoylquinic acid inhibits tumor necrosis factor-\u03b1-stimulated production of inflammatory mediators in keratinocytes via suppression of Akt- and NF-\u03baB-pathways. Int Immunopharmacol 11:1715\u20131723. https:\/\/doi.org\/10.1016\/j.intimp.2011.06.003","journal-title":"Int Immunopharmacol"},{"key":"2098_CR22","doi-asserted-by":"publisher","first-page":"1595","DOI":"10.1177\/1934578X1701201018","volume":"12","author":"DECV Lemos","year":"2017","unstructured":"Lemos DECV, Cavalcante-Silva LHA, Lima EA et al (2017) Anti-inflammatory effect of discretamine, a protoberberine alkaloid isolated from Duguetia moricandiana. NPC 12:1595\u20131597. https:\/\/doi.org\/10.1177\/1934578X1701201018","journal-title":"NPC"},{"key":"2098_CR23","doi-asserted-by":"publisher","first-page":"601","DOI":"10.1016\/0024-3205(69)90021-6","volume":"8","author":"L Levy","year":"1969","unstructured":"Levy L (1969) Carrageenan paw edema in the mouse. Life Sci 8:601\u2013606","journal-title":"Life Sci"},{"key":"2098_CR24","doi-asserted-by":"publisher","first-page":"7688","DOI":"10.3390\/ijms22147688","volume":"22","author":"P Li","year":"2021","unstructured":"Li P, Chang M (2021) Roles of PRR-Mediated Signaling Pathways in the Regulation of Oxidative Stress and Inflammatory Diseases. Int J Mol Sci 22:7688. https:\/\/doi.org\/10.3390\/ijms22147688","journal-title":"Int J Mol Sci"},{"key":"2098_CR25","doi-asserted-by":"publisher","first-page":"332","DOI":"10.1016\/j.intimp.2015.02.002","volume":"25","author":"Y-Y Li","year":"2015","unstructured":"Li Y-Y, Huang S-S, Lee MM et al (2015) Anti-inflammatory activities of cardamonin from Alpinia katsumadai through heme oxygenase-1 induction and inhibition of NF-\u03baB and MAPK signalling pathway in the carrageenan-induced paw edema. Int Immunopharmacol 25:332\u2013339. https:\/\/doi.org\/10.1016\/j.intimp.2015.02.002","journal-title":"Int Immunopharmacol"},{"issue":"2","key":"2098_CR26","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1016\/j.jpain.2006.06.010","volume":"8","author":"LC Loram","year":"2007","unstructured":"Loram LC, Fuller A, Fick LG et al (2007) Cytokine profiles during carrageenan-induced inflammatory hyperalgesia in rat muscle and hind paw. J Pain 8(2):127\u2013136. https:\/\/doi.org\/10.1016\/j.jpain.2006.06.010","journal-title":"J Pain"},{"key":"2098_CR27","unstructured":"Lorenzi H (2000) Plantas Daninhas do Brasil: Terrestre, Aqu\u00e1tica Parasitas e T\u00f3xicas. Instituto Plantarum, Nova Odessa"},{"key":"2098_CR28","doi-asserted-by":"publisher","first-page":"726","DOI":"10.1016\/j.phymed.2010.01.013","volume":"17","author":"Y Luo","year":"2010","unstructured":"Luo Y, Liu M, Xia Y et al (2010) Therapeutic effect of norisoboldine, an alkaloid isolated from Radix Linderae, on collagen-induced arthritis in mice. Phytomedicine 17:726\u2013731. https:\/\/doi.org\/10.1016\/j.phymed.2010.01.013","journal-title":"Phytomedicine"},{"key":"2098_CR29","doi-asserted-by":"publisher","first-page":"1840","DOI":"10.21577\/0103-5053.20210075","volume":"32","author":"AL Macedo","year":"2021","unstructured":"Macedo AL, Boaretto AG, da Silva AN et al (2021) Evaluation of the Effect of Brazilian Savanna (Cerrado) Seasons in Flavonoids and Alkaloids Accumulation: The Case of Duguetia furfuracea. JBCS 32:1840\u20131850. https:\/\/doi.org\/10.21577\/0103-5053.20210075","journal-title":"JBCS"},{"key":"2098_CR30","doi-asserted-by":"publisher","first-page":"287","DOI":"10.1016\/0891-5849(92)90116-X","volume":"12","author":"LA Martinez","year":"1992","unstructured":"Martinez LA, Rios JL, Paya M et al (1992) Inhibition of nonenzymic lipid peroxidation by benzylisoquinoline alkaloids. Free Radic Biol Med 12:287\u2013292. https:\/\/doi.org\/10.1016\/0891-5849(92)90116-X","journal-title":"Free Radic Biol Med"},{"key":"2098_CR31","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1016\/j.cca.2016.02.010","volume":"455","author":"S Mateen","year":"2016","unstructured":"Mateen S, Zafar A, Moin S et al (2016) Understanding the role of cytokines in the pathogenesis of rheumatoid arthritis. Clin Chim Acta 455:161\u2013171. https:\/\/doi.org\/10.1016\/j.cca.2016.02.010","journal-title":"Clin Chim Acta"},{"key":"2098_CR32","doi-asserted-by":"publisher","first-page":"355","DOI":"10.1016\/s0301-0082(02)00009-6","volume":"66","author":"MJ Millan","year":"2002","unstructured":"Millan MJ (2002) Descending control of pain. Prog Neurobiol 66:355\u2013474. https:\/\/doi.org\/10.1016\/s0301-0082(02)00009-6","journal-title":"Prog Neurobiol"},{"key":"2098_CR33","doi-asserted-by":"publisher","first-page":"559","DOI":"10.1021\/np000436s","volume":"64","author":"I Muhammad","year":"2001","unstructured":"Muhammad I, Dunbar DC, Takamatsu S et al (2001) Antimalarial, cytotoxic, and antifungal alkaloids from Duguetia hadrantha. J Nat Prod 64:559\u2013562. https:\/\/doi.org\/10.1021\/np000436s","journal-title":"J Nat Prod"},{"key":"2098_CR34","doi-asserted-by":"publisher","first-page":"415","DOI":"10.1016\/0304-3959(92)90249-B","volume":"49","author":"AO Oluyomi","year":"1992","unstructured":"Oluyomi AO, Hart SL, Smith TW (1992) Differential antinociceptive effects of morphine and methylmorphine in the formalin test. Pain 49:415\u2013418. https:\/\/doi.org\/10.1016\/0304-3959(92)90249-B","journal-title":"Pain"},{"key":"2098_CR35","unstructured":"Pott A, Pott VJ (1994) Plantas do Pantanal. EMBRAPA, Corumba"},{"key":"2098_CR36","doi-asserted-by":"publisher","first-page":"733","DOI":"10.1038\/s41598-019-57406-7","volume":"10","author":"Z Qing","year":"2020","unstructured":"Qing Z, Xu Y, Yu L et al (2020) Investigation of fragmentation behaviours of isoquinoline alkaloids by mass spectrometry combined with computational chemistry. Sci Rep 10:733. https:\/\/doi.org\/10.1038\/s41598-019-57406-7","journal-title":"Sci Rep"},{"key":"2098_CR37","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1016\/j.it.2016.10.001","volume":"38","author":"FAP Ribeiro","year":"2017","unstructured":"Ribeiro FAP, Verri WA, Chiu IM (2017) Nociceptor sensory neuron-immune interactions in pain and inflammation. Trends Immunol 38:5\u201319. https:\/\/doi.org\/10.1016\/j.it.2016.10.001","journal-title":"Trends Immunol"},{"key":"2098_CR38","doi-asserted-by":"publisher","first-page":"2277","DOI":"10.1097\/j.pain.0000000000001328","volume":"159","author":"A Rodriguez-Gaztelumendi","year":"2018","unstructured":"Rodriguez-Gaztelumendi A, Spahn V, Labuz D et al (2018) Analgesic effects of a novel pH-dependent \u03bc-opioid receptor agonist in models of neuropathic and abdominal pain. Pain 159:2277\u20132284. https:\/\/doi.org\/10.1097\/j.pain.0000000000001328","journal-title":"Pain"},{"key":"2098_CR39","doi-asserted-by":"publisher","first-page":"396","DOI":"10.1016\/j.ejphar.2011.05.053","volume":"667","author":"H Sadeghi","year":"2011","unstructured":"Sadeghi H, Hajhashemi V, Minaiyan M et al (2011) A study on the mechanisms involving the anti-inflammatory efect of amitriptyline in carrageenan-induced paw edema in rats. Eur J Pharmacol 667:396\u2013401. https:\/\/doi.org\/10.1016\/j.ejphar.2011.05.053","journal-title":"Eur J Pharmacol"},{"key":"2098_CR40","doi-asserted-by":"publisher","first-page":"325","DOI":"10.1016\/j.jep.2018.11.017","volume":"231","author":"AA Saldanha","year":"2019","unstructured":"Saldanha AA, Vieira L, Ribeiro RIMA et al (2019) Chemical composition and evaluation of the anti-inflammatory and antinociceptive activities of Duguetia furfuracea essential oil: efect on edema, leukocyte recruitment, tumor necrosis factor alpha production, iNOS expression, and adenosinergic and opioidergic systems. J Ethnopharmacol 231:325\u2013336. https:\/\/doi.org\/10.1016\/j.jep.2018.11.017","journal-title":"J Ethnopharmacol"},{"key":"2098_CR41","doi-asserted-by":"publisher","first-page":"409","DOI":"10.1007\/s10787-020-00775-7","volume":"29","author":"AA Saldanha","year":"2021","unstructured":"Saldanha AA, Vieira L, Maia DS et al (2021) Anti-inflammatory and antinociceptive activities of a phenylpropanoid-enriched fraction of Duguetia furfuracea. Inflammopharmacol 29:409\u2013422. https:\/\/doi.org\/10.1007\/s10787-020-00775-7","journal-title":"Inflammopharmacol"},{"key":"2098_CR42","doi-asserted-by":"publisher","first-page":"2569","DOI":"10.1016\/j.micinf.2006.06.011","volume":"8","author":"HC Santiago","year":"2006","unstructured":"Santiago HC, Pires MFB, Souza DG et al (2006) Platelet activating factor receptor-deficient mice present delayed interferon-\u03b3 upregulation and high susceptibility to Leishmania amazonensis infection. Microbes Infect 8:2569\u20132577. https:\/\/doi.org\/10.1016\/j.micinf.2006.06.011","journal-title":"Microbes Infect"},{"key":"2098_CR43","doi-asserted-by":"publisher","first-page":"325","DOI":"10.1016\/j.jep.2004.03.016","volume":"92","author":"M Sayyah","year":"2004","unstructured":"Sayyah M, Hadidi N, Kamalinejad M (2004) Analgesic and anti-inflammatory activity of Lactuca sativa seed extract in rats. J Ethnopharmacol 92:325. https:\/\/doi.org\/10.1016\/j.jep.2004.03.016","journal-title":"J Ethnopharmacol"},{"issue":"6","key":"2098_CR44","doi-asserted-by":"publisher","first-page":"2212","DOI":"10.1002\/med.21703","volume":"40","author":"XF Shang","year":"2020","unstructured":"Shang XF, Yang CJ, Morris-Natschke SL et al (2020) Biologically active isoquinoline alkaloids covering 2014-2018. Med Res Rev 40(6):2212\u20132289. https:\/\/doi.org\/10.1002\/med.21703","journal-title":"Med Res Rev"},{"key":"2098_CR45","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1002\/pca.2718","volume":"29","author":"Y Shangguan","year":"2018","unstructured":"Shangguan Y, He J, Kang Y et al (2018) Structural characterisation of alkaloids in leaves and roots of Stephania kwangsiensis by LC-QTOF-MS. Phytochem Anal 29:101\u2013111. https:\/\/doi.org\/10.1002\/pca.2718","journal-title":"Phytochem Anal"},{"key":"2098_CR46","doi-asserted-by":"publisher","first-page":"347","DOI":"10.1016\/0304-3959(89)90222-4","volume":"38","author":"M Shibata","year":"1989","unstructured":"Shibata M, Ohkubo T, Takahashi H et al (1989) Modifed formalin test: characteristic biphasic pain response. Pain 38:347\u2013352. https:\/\/doi.org\/10.1016\/0304-3959(89)90222-4","journal-title":"Pain"},{"key":"2098_CR47","first-page":"15","volume":"8","author":"I Silberbauer-Gottsberger","year":"1981","unstructured":"Silberbauer-Gottsberger I (1981) O cerrado como potencial de plantas medicinais e t\u00f3xicas. Or\u00e9ades 8:15\u201330","journal-title":"Or\u00e9ades"},{"key":"2098_CR48","doi-asserted-by":"publisher","first-page":"1809","DOI":"10.1590\/S0100-40422007000800004","volume":"30","author":"DB Silva","year":"2007","unstructured":"Silva DB, Matos MFC, Nakashita ST et al (2007) Isolamento e avalia\u00e7\u00e3o da atividade citot\u00f3xica de alguns alcal\u00f3ides oxaporf\u00ednicos obtidos de Annonaceae. Quim Nova 30:1809\u20131812. https:\/\/doi.org\/10.1590\/S0100-40422007000800004","journal-title":"Quim Nova"},{"key":"2098_CR49","doi-asserted-by":"publisher","first-page":"1059","DOI":"10.1016\/j.phymed.2009.03.019","volume":"16","author":"DB Silva","year":"2009","unstructured":"Silva DB, Tulli ECO, Milit\u00e3o GCG et al (2009) The antitumoral, trypanocidal and antileishmanial activities of extract and alkaloids isolated from Duguetia furfuracea. Phytomedicine 16:1059\u20131063. https:\/\/doi.org\/10.1016\/j.phymed.2009.03.019","journal-title":"Phytomedicine"},{"key":"2098_CR50","doi-asserted-by":"publisher","DOI":"10.1590\/1678-4324-2021200748","volume":"64","author":"MGC Silva","year":"2021","unstructured":"Silva MGC, Hort MA, Hadrich G et al (2021) Anti-inflammatory and antioxidant effects of the microalga Pediastrum boryanum in carrageenan-induced rat paw edema. BABT 64:e21200748. https:\/\/doi.org\/10.1590\/1678-4324-2021200748","journal-title":"BABT"},{"key":"2098_CR51","doi-asserted-by":"publisher","first-page":"837","DOI":"10.1002\/rcm.7165","volume":"29","author":"HJ Sim","year":"2015","unstructured":"Sim HJ, Yoon SH, Kim MS et al (2015) Identification of alkaloid constituents from Fangchi species using pH control liquid-liquid extraction and liquid chromatography coupled to quadrupole time-of-flight mass spectrometry. Rapid Commun Mass Spectrom 29:837\u2013854. https:\/\/doi.org\/10.1002\/rcm.7165","journal-title":"Rapid Commun Mass Spectrom"},{"key":"2098_CR52","doi-asserted-by":"publisher","first-page":"8515","DOI":"10.3390\/molecules16108515","volume":"16","author":"AL Souto","year":"2011","unstructured":"Souto AL, Tavares JF, da Silva MS et al (2011) Anti-inflammatory activity of alkaloids: an update from 2000 to 2010. Molecules 16:8515\u20138534. https:\/\/doi.org\/10.3390\/molecules16108515","journal-title":"Molecules"},{"key":"2098_CR53","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1016\/0304-3959(92)90003-T","volume":"51","author":"A Tj\u00f8lsen","year":"1992","unstructured":"Tj\u00f8lsen A, Berge O-G, Hunskaar S et al (1992) The formalin test: an evaluation of the method. Pain 51:5\u201317. https:\/\/doi.org\/10.1016\/0304-3959(92)90003-T","journal-title":"Pain"},{"key":"2098_CR54","unstructured":"TROPICOS (2018) Duguetia furfuracea (A. St. -Hil.) Saff.\u00a0http:\/\/www.tropicos.org\/Name\/50238396?\u3009tab=distribution. Accessed 8 March 2018."},{"key":"2098_CR55","doi-asserted-by":"publisher","first-page":"289","DOI":"10.1590\/S1516-93322006000200015","volume":"42","author":"MSR Turolla","year":"2006","unstructured":"Turolla MSR, Nascimento ES (2006) Informa\u00e7\u00f5es toxicol\u00f3gicas de alguns fitoter\u00e1picos utilizados no Brasil. Rev Bras Cienc Farm 42:289\u2013306. https:\/\/doi.org\/10.1590\/S1516-93322006000200015","journal-title":"Rev Bras Cienc Farm"},{"key":"2098_CR56","doi-asserted-by":"publisher","first-page":"304","DOI":"10.1016\/S0022-3565(25)20136-7","volume":"278","author":"ZR Vaz","year":"1996","unstructured":"Vaz ZR, Filho VC, Yunes RA et al (1996) Antinociceptive action of 2-(4-bromobenzoyl)-3-methyl-4,6-dimethoxy benzofuran, a novel xanthoxyline derivative on chemical and thermal models of nociception in mice. J Pharmacol Exp Ther 278:304\u2013312","journal-title":"J Pharmacol Exp Ther"},{"key":"2098_CR57","doi-asserted-by":"publisher","unstructured":"Vogel HG, Vogel WH (1997) Analgesic, anti-inflammatory, and antipyretic activity. Drug discovery and evaluation. Springer, Berlin, pp 360\u2013420. https:\/\/doi.org\/10.1007\/978-3-540-70995-4_9","DOI":"10.1007\/978-3-540-70995-4_9"},{"key":"2098_CR58","doi-asserted-by":"publisher","first-page":"8839","DOI":"10.2147\/JIR.S476824","volume":"17","author":"Y Wang","year":"2024","unstructured":"Wang Y, Zhao X, Wang J et al (2024) Norisoboldine reduces arthritis severity by attenuating inflammation, oxidative stress, and extracellular matrix degradation in a rat model of rheumatoid arthritis. J Inflamm Res 17:8839\u20138852. https:\/\/doi.org\/10.2147\/JIR.S476824","journal-title":"J Inflamm Res"},{"key":"2098_CR59","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1055\/s-0043-113447","volume":"84","author":"X Yang","year":"2018","unstructured":"Yang X, Gao X, Cao Y et al (2018) Anti-inflammatory effects of Boldine and Reticuline isolated from Litsea cubeba through JAK2\/STAT3 and NF-\u03baB signaling pathways. Planta Med 84:20\u201325. https:\/\/doi.org\/10.1055\/s-0043-113447","journal-title":"Planta Med"},{"key":"2098_CR60","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1016\/s1090-3801(98)90047-7","volume":"2","author":"K Yashpal","year":"1998","unstructured":"Yashpal K, Coderre TJ (1998) Influence of formalin concentration on the antinociceptive effects of anti-inflammatory drugs in the formalin test in rats: separate mechanisms underlying the nociceptive effects of low-and high-concentration formalin. Eur J Pain 2:63\u201368. https:\/\/doi.org\/10.1016\/s1090-3801(98)90047-7","journal-title":"Eur J Pain"},{"key":"2098_CR61","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1016\/s0378-8741(03)00224-1","volume":"88","author":"W Yin","year":"2003","unstructured":"Yin W, Wang TS, Yin FZ et al (2003) Analgesic and anti-inflammatory properties of brucine and brucine N-oxide extracted from seeds of Strychnos nux-vomica. J Ethnopharmacol 88:205\u2013214. https:\/\/doi.org\/10.1016\/s0378-8741(03)00224-1","journal-title":"J Ethnopharmacol"}],"container-title":["Inflammopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10787-025-02098-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10787-025-02098-x","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10787-025-02098-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,21]],"date-time":"2026-02-21T01:12:18Z","timestamp":1771636338000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10787-025-02098-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,5]]},"references-count":61,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,2]]}},"alternative-id":["2098"],"URL":"https:\/\/doi.org\/10.1007\/s10787-025-02098-x","relation":{},"ISSN":["0925-4692","1568-5608"],"issn-type":[{"value":"0925-4692","type":"print"},{"value":"1568-5608","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1,5]]},"assertion":[{"value":"24 July 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 December 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 January 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no conflicts of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"The experiments were approved by the ethics committee of the Federal University of S\u00e3o Jo\u00e3o del-Rei, Brazil (CEUA\/UFSJ, protocol 022\/2018).","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}}]}}