{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T22:41:12Z","timestamp":1793400072057,"version":"4.5.0"},"reference-count":136,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T00:00:00Z","timestamp":1771459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T00:00:00Z","timestamp":1771459200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Inflammopharmacol"],"published-print":{"date-parts":[[2026,3]]},"DOI":"10.1007\/s10787-026-02113-9","type":"journal-article","created":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T03:15:24Z","timestamp":1771470924000},"page":"1399-1424","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Molecular insights into glial neuroimmune cross reactivity with CNS antigens and its role in neuroinflammation"],"prefix":"10.1007","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6111-2407","authenticated-orcid":false,"given":"Anil Kumar","family":"Yadav","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Priyanka","family":"Verma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashish","family":"Srivastava","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Parul","family":"Srivastava","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rohit","family":"Rai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shubham","family":"Rathour","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,2,19]]},"reference":[{"key":"2113_CR1","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1016\/j.nbd.2009.07.030","volume":"37","author":"NJ Abbott","year":"2010","unstructured":"Abbott NJ, Patabendige AAK, Dolman DEM, Yusof SR, Begley DJ (2010) Structure and function of the blood-brain barrier. Neurobiol Dis 37:13\u201325","journal-title":"Neurobiol Dis"},{"issue":"7","key":"2113_CR2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24076274","volume":"24","author":"A Adamczyk","year":"2023","unstructured":"Adamczyk A (2023) Glial-neuronal interactions in neurological disorders: molecular mechanisms and potential points for intervention. Int J Mol Sci 24(7):6274. https:\/\/doi.org\/10.3390\/ijms24076274","journal-title":"Int J Mol Sci"},{"issue":"4","key":"2113_CR3","doi-asserted-by":"publisher","DOI":"10.3390\/cells11040659","volume":"11","author":"R Afridi","year":"2022","unstructured":"Afridi R, Tsuda M, Ryu H, Suk K (2022) The function of glial cells in the neuroinflammatory and neuroimmunological responses. Cells 11(4):659. https:\/\/doi.org\/10.3390\/cells11040659","journal-title":"Cells"},{"issue":"24","key":"2113_CR4","doi-asserted-by":"publisher","DOI":"10.3390\/nano12244494","volume":"12","author":"O Afzal","year":"2022","unstructured":"Afzal O, Altamimi ASA, Nadeem MS, Alzarea SI, Almalki WH, Tariq A, Mubeen B, Murtaza BN, Iftikhar S, Riaz N, Kazmi I (2022) Nanoparticles in drug delivery: from history to therapeutic applications. Nanomaterials (Basel) 12(24):4494. https:\/\/doi.org\/10.3390\/nano12244494","journal-title":"Nanomaterials (Basel)"},{"key":"2113_CR5","first-page":"1","volume":"13","author":"A Agrawal","year":"2025","unstructured":"Agrawal A, Ghosh V, Uddin A, Jain P (2025) A comprehensive review on plant bioactive compounds-based novel drug delivery system for the treatment of rheumatoid arthritis. Pharm Nanotechnol 13:1\u201316","journal-title":"Pharm Nanotechnol"},{"key":"2113_CR6","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1016\/j.neures.2023.02.001","volume":"197","author":"M Albini","year":"2023","unstructured":"Albini M, Krawczun-Rygmaczewska A, Cesca F (2023) Astrocytes and brain-derived neurotrophic factor (BDNF). Neurosci Res 197:42\u201351","journal-title":"Neurosci Res"},{"issue":"23","key":"2113_CR7","doi-asserted-by":"publisher","DOI":"10.3390\/molecules27238448","volume":"27","author":"E Angelopoulou","year":"2022","unstructured":"Angelopoulou E, Pyrgelis ES, Piperi C (2022) Emerging potential of the phosphodiesterase (PDE) inhibitor Ibudilast for neurodegenerative diseases: an update on preclinical and clinical evidence. Molecules 27(23):8448. https:\/\/doi.org\/10.3390\/molecules27238448","journal-title":"Molecules"},{"issue":"27","key":"2113_CR8","doi-asserted-by":"publisher","first-page":"24625","DOI":"10.1074\/jbc.M112063200","volume":"277","author":"A Ariga","year":"2002","unstructured":"Ariga A, Namekawa J, Matsumoto N, Inoue J, Umezawa K (2002) Inhibition of tumor necrosis factor-\u03b1-induced nuclear translocation and activation of NF-\u03baB by dehydroxymethylepoxyquinomicin*. J Biol Chem 277(27):24625\u201324630","journal-title":"J Biol Chem"},{"issue":"6","key":"2113_CR9","doi-asserted-by":"publisher","first-page":"1164","DOI":"10.5114\/aoms.2015.56342","volume":"11","author":"S Bathina","year":"2015","unstructured":"Bathina S, Das UN (2015) Brain-derived neurotrophic factor and its clinical implications. Arch Med Sci 11(6):1164\u20131178. https:\/\/doi.org\/10.5114\/aoms.2015.56342","journal-title":"Arch Med Sci"},{"key":"2113_CR10","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2020.00209","volume":"14","author":"A Bernaus","year":"2020","unstructured":"Bernaus A, Blanco S, Sevilla A (2020) Glia crosstalk in neuroinflammatory diseases. Front Cell Neurosci 14:209. https:\/\/doi.org\/10.3389\/fncel.2020.00209","journal-title":"Front Cell Neurosci"},{"key":"2113_CR11","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2024.117177","volume":"178","author":"NK Bhol","year":"2024","unstructured":"Bhol NK, Bhanjadeo MM, Singh AK, Dash UC, Ojha RR, Majhi S et al (2024) The interplay between cytokines, inflammation, and antioxidants: mechanistic insights and therapeutic potentials of various antioxidants and anti-cytokine compounds. Biomed Pharmacother 178:117177","journal-title":"Biomed Pharmacother"},{"key":"2113_CR12","doi-asserted-by":"publisher","first-page":"578180","DOI":"10.1016\/j.jneuroim.2023.578180","volume":"383","author":"K Biswas","year":"2023","unstructured":"Biswas K (2023) Microglia mediated neuroinflammation in neurodegenerative diseases: a review on the cell signaling pathways involved in microglial activation. J Neuroimmunol 383:578180","journal-title":"J Neuroimmunol"},{"issue":"10","key":"2113_CR13","doi-asserted-by":"publisher","DOI":"10.1002\/mnfr.202400752","volume":"69","author":"M Bodur","year":"2025","unstructured":"Bodur M, Yilmaz B, A\u011fag\u00fcnd\u00fcz D, Ozogul Y (2025) Immunomodulatory effects of omega-3 fatty acids: mechanistic insights and health implications. Mol Nutr Food Res 69(10):e202400752. https:\/\/doi.org\/10.1002\/mnfr.202400752","journal-title":"Mol Nutr Food Res"},{"issue":"10","key":"2113_CR14","doi-asserted-by":"publisher","first-page":"4185","DOI":"10.1074\/jbc.M116.745877","volume":"292","author":"P Bonvin","year":"2017","unstructured":"Bonvin P, Gueneau F, Buatois V, Charreton-Galby M, Lasch S, Messmer M, Christen U, Luster AD, Johnson Z, Ferlin W, Kosco-Vilbois M, Proudfoot A, Fischer N (2017) Antibody neutralization of CXCL10 in vivo is dependent on binding to free and not endothelial-bound chemokine: implications for the design of a new generation of anti-chemokine therapeutic antibodies. J Biol Chem 292(10):4185\u20134197. https:\/\/doi.org\/10.1074\/jbc.M116.745877","journal-title":"J Biol Chem"},{"key":"2113_CR15","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2021.135663","volume":"746","author":"VL Brayman","year":"2021","unstructured":"Brayman VL, Taetzsch T, Miko M, Dahal S, Risher WC, Valdez G (2021) Roles of the synaptic molecules Hevin and SPARC in mouse neuromuscular junction development and repair. Neurosci Lett 746:135663","journal-title":"Neurosci Lett"},{"key":"2113_CR16","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2020.576037","volume":"14","author":"SR Cerqueira","year":"2020","unstructured":"Cerqueira SR, Ayad NG, Lee JK (2020) Neuroinflammation treatment via targeted delivery of nanoparticles. Front Cell Neurosci 14:576037. https:\/\/doi.org\/10.3389\/fncel.2020.576037","journal-title":"Front Cell Neurosci"},{"key":"2113_CR17","doi-asserted-by":"publisher","first-page":"633","DOI":"10.1016\/j.neuropharm.2015.10.010","volume":"110","author":"KA Chamberlain","year":"2016","unstructured":"Chamberlain KA, Nanescu SE, Psachoulia K, Huang JK (2016) Oligodendrocyte regeneration: its significance in myelin replacement and neuroprotection in multiple sclerosis. Neuropharmacology 110:633\u2013643. https:\/\/doi.org\/10.1016\/j.neuropharm.2015.10.010","journal-title":"Neuropharmacology"},{"key":"2113_CR18","doi-asserted-by":"crossref","unstructured":"Chen S, Wu L, Lang B, Zhao G, Zhang W (2025) Sphingosine 1-phosphate receptor 1 modulators exert neuroprotective effects in central nervous system disorders. Front Pharmacol 16\u20132025","DOI":"10.3389\/fphar.2025.1516991"},{"key":"2113_CR19","doi-asserted-by":"publisher","first-page":"150225","DOI":"10.1016\/j.bbrc.2024.150225","volume":"724","author":"Y Cheng","year":"2024","unstructured":"Cheng Y, Xu SM, Santucci K, Lindner G, Janitz M (2024) Machine learning and related approaches in transcriptomics. Biochem Biophys Res Commun 724:150225","journal-title":"Biochem Biophys Res Commun"},{"issue":"1","key":"2113_CR20","doi-asserted-by":"publisher","first-page":"158","DOI":"10.1002\/med.21599","volume":"40","author":"MA Cinelli","year":"2020","unstructured":"Cinelli MA, Do HT, Miley GP, Silverman RB (2020) Inducible nitric oxide synthase: regulation, structure, and inhibition. Med Res Rev 40(1):158\u2013189. https:\/\/doi.org\/10.1002\/med.21599","journal-title":"Med Res Rev"},{"issue":"1","key":"2113_CR21","doi-asserted-by":"publisher","first-page":"441","DOI":"10.1146\/annurev-immunol-051116-052358","volume":"35","author":"M Colonna","year":"2017","unstructured":"Colonna M, Butovsky O (2017) Microglia function in the central nervous system during health and neurodegeneration. Annu Rev Immunol 35(1):441\u2013468. https:\/\/doi.org\/10.1146\/annurev-immunol-051116-052358","journal-title":"Annu Rev Immunol"},{"issue":"16","key":"2113_CR22","doi-asserted-by":"publisher","first-page":"4996","DOI":"10.3390\/molecules26164996","volume":"26","author":"B Das","year":"2021","unstructured":"Das B, Sarkar C, Rawat VS, Kalita D, Deka S, Agnihotri A (2021) Promise of the NLRP3 inflammasome inhibitors in in vivo disease models. Molecules 26(16):4996","journal-title":"Molecules"},{"key":"2113_CR23","doi-asserted-by":"crossref","unstructured":"Deb VK, Jain U (2025) Activation of transforming growth factor beta 1 through integrin alpha V beta 6 and its molecular insights into cancer progression, and future directions. Int J Biol Macromol 147121","DOI":"10.1016\/j.ijbiomac.2025.147121"},{"issue":"6","key":"2113_CR24","doi-asserted-by":"publisher","first-page":"313","DOI":"10.1089\/jir.2008.0027","volume":"29","author":"SL Deshmane","year":"2009","unstructured":"Deshmane SL, Kremlev S, Amini S, Sawaya BE (2009) Monocyte chemoattractant protein-1 (MCP-1): an overview. J Interferon Cytokine Res 29(6):313\u2013326. https:\/\/doi.org\/10.1089\/jir.2008.0027","journal-title":"J Interferon Cytokine Res"},{"issue":"1","key":"2113_CR25","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1016\/j.immuni.2017.06.020","volume":"47","author":"F Di Virgilio","year":"2017","unstructured":"Di Virgilio F, Dal Ben D, Sarti AC, Giuliani AL, Falzoni S (2017) The P2X7 receptor in infection and inflammation. Immunity 47(1):15\u201331. https:\/\/doi.org\/10.1016\/j.immuni.2017.06.020","journal-title":"Immunity"},{"issue":"6","key":"2113_CR26","doi-asserted-by":"publisher","first-page":"2361","DOI":"10.1084\/jem.184.6.2361","volume":"184","author":"SD D'Souza","year":"1996","unstructured":"D\u2019Souza SD, Bonetti B, Balasingam V, Cashman NR, Barker PA, Troutt AB, Raine CS, Antel JP (1996) Multiple sclerosis: Fas signaling in oligodendrocyte cell death. J Exp Med 184(6):2361\u20132370. https:\/\/doi.org\/10.1084\/jem.184.6.2361","journal-title":"J Exp Med"},{"issue":"52","key":"2113_CR27","doi-asserted-by":"publisher","first-page":"21243","DOI":"10.1074\/jbc.RA117.000123","volume":"292","author":"RL Edwards","year":"2017","unstructured":"Edwards RL, Luis PB, Varuzza PV, Joseph AI, Presley SH, Chaturvedi R, Schneider C (2017) The anti-inflammatory activity of curcumin is mediated by its oxidative metabolites. J Biol Chem 292(52):21243\u201321252. https:\/\/doi.org\/10.1074\/jbc.RA117.000123","journal-title":"J Biol Chem"},{"key":"2113_CR28","doi-asserted-by":"publisher","DOI":"10.3389\/frobt.2024.1444763","volume":"11","author":"M Ennab","year":"2024","unstructured":"Ennab M, Mcheick H (2024) Enhancing interpretability and accuracy of AI models in healthcare: a comprehensive review on challenges and future directions. Front Robot AI 11:1444763. https:\/\/doi.org\/10.3389\/frobt.2024.1444763","journal-title":"Front Robot AI"},{"key":"2113_CR29","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.01426","volume":"10","author":"E Fahey","year":"2019","unstructured":"Fahey E, Doyle SL (2019) IL-1 family cytokine regulation of vascular permeability and angiogenesis. Front Immunol 10:1426. https:\/\/doi.org\/10.3389\/fimmu.2019.01426","journal-title":"Front Immunol"},{"issue":"3","key":"2113_CR30","doi-asserted-by":"publisher","first-page":"349","DOI":"10.1002\/glia.22437","volume":"61","author":"L Fellner","year":"2013","unstructured":"Fellner L, Irschick R, Schanda K, Reindl M, Klimaschewski L, Poewe W, Wenning GK, Stefanova N (2013) Toll-like receptor 4 is required for \u03b1-synuclein dependent activation of microglia and astroglia. Glia 61(3):349\u2013360. https:\/\/doi.org\/10.1002\/glia.22437","journal-title":"Glia"},{"issue":"23","key":"2113_CR31","doi-asserted-by":"publisher","first-page":"23889","DOI":"10.1021\/acsomega.5c00549","volume":"10","author":"FJN Ferreira","year":"2025","unstructured":"Ferreira FJN, Carneiro AS (2025) AI-driven drug discovery: a comprehensive review. ACS Omega 10(23):23889\u201323903. https:\/\/doi.org\/10.1021\/acsomega.5c00549","journal-title":"ACS Omega"},{"key":"2113_CR32","doi-asserted-by":"publisher","first-page":"1009","DOI":"10.1016\/j.neuron.2014.01.013","volume":"81","author":"AE Frakes","year":"2014","unstructured":"Frakes AE, Ferraiuolo L, Haidet-Phillips AM, Schmelzer L, Braun L, Miranda CJ et al (2014) Microglia induce motor neuron death via the classical NF-\u03baB pathway in amyotrophic lateral sclerosis. Neuron 81:1009\u20131023. https:\/\/doi.org\/10.1016\/j.neuron.2014.01.013","journal-title":"Neuron"},{"issue":"6","key":"2113_CR33","doi-asserted-by":"publisher","DOI":"10.3390\/cimb47060417","volume":"47","author":"M Garc\u00eda-Dom\u00ednguez","year":"2025","unstructured":"Garc\u00eda-Dom\u00ednguez M (2025) Neuroinflammation: mechanisms, dual roles, and therapeutic strategies in neurological disorders. Curr Issues Mol Biol 47(6):417. https:\/\/doi.org\/10.3390\/cimb47060417","journal-title":"Curr Issues Mol Biol"},{"issue":"1","key":"2113_CR34","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1097\/PPO.0b013e3182431c6f","volume":"18","author":"ER Gerstner","year":"2012","unstructured":"Gerstner ER, Batchelor TT (2012) Antiangiogenic therapy for glioblastoma. Cancer J 18(1):45\u201350. https:\/\/doi.org\/10.1097\/PPO.0b013e3182431c6f","journal-title":"Cancer J"},{"issue":"9","key":"2113_CR35","doi-asserted-by":"publisher","first-page":"805","DOI":"10.1016\/j.it.2020.07.007","volume":"41","author":"F Giovannoni","year":"2020","unstructured":"Giovannoni F, Quintana FJ (2020) The role of astrocytes in CNS inflammation. Trends Immunol 41(9):805\u2013819. https:\/\/doi.org\/10.1016\/j.it.2020.07.007","journal-title":"Trends Immunol"},{"key":"2113_CR36","doi-asserted-by":"publisher","DOI":"10.1016\/j.ceca.2024.102856","volume":"119","author":"AL Gonz\u00e1lez-Cota","year":"2024","unstructured":"Gonz\u00e1lez-Cota AL, Mart\u00ednez-Flores D, Rosendo-Pineda MJ, Vaca L (2024) NMDA receptor-mediated Ca2+ signaling: impact on cell cycle regulation and the development of neurodegenerative diseases and cancer. Cell Calcium 119:102856. https:\/\/doi.org\/10.1016\/j.ceca.2024.102856","journal-title":"Cell Calcium"},{"issue":"15","key":"2113_CR37","doi-asserted-by":"publisher","first-page":"3385","DOI":"10.12998\/wjcc.v11.i15.3385","volume":"11","author":"L Gradisnik","year":"2023","unstructured":"Gradisnik L, Velnar T (2023) Astrocytes in the central nervous system and their functions in health and disease: a review. World J Clin Cases 11(15):3385\u20133394. https:\/\/doi.org\/10.12998\/wjcc.v11.i15.3385","journal-title":"World J Clin Cases"},{"issue":"1-2","key":"2113_CR38","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1016\/j.jns.2013.02.011","volume":"328","author":"A Groves","year":"2013","unstructured":"Groves A, Kihara Y, Chun J (2013) Fingolimod: direct CNS effects of sphingosine 1-phosphate (S1P) receptor modulation and implications in multiple sclerosis therapy. J Neurol Sci 328(1\u20132):9\u201318. https:\/\/doi.org\/10.1016\/j.jns.2013.02.011","journal-title":"J Neurol Sci"},{"key":"2113_CR39","doi-asserted-by":"publisher","DOI":"10.1177\/1756286418774254","volume":"11","author":"E G\u00fclke","year":"2018","unstructured":"G\u00fclke E, Gelderblom M, Magnus T (2018) Danger signals in stroke and their role on microglia activation after ischemia. Ther Adv Neurol Disord 11:1756286418774254. https:\/\/doi.org\/10.1177\/1756286418774254","journal-title":"Ther Adv Neurol Disord"},{"issue":"6","key":"2113_CR40","doi-asserted-by":"publisher","first-page":"1400","DOI":"10.1172\/JCI118927","volume":"98","author":"JD Heiss","year":"1996","unstructured":"Heiss JD, Papavassiliou E, Merrill MJ, Nieman L, Knightly JJ, Walbridge S, Edwards NA, Oldfield EH (1996) Mechanism of dexamethasone suppression of brain tumor-associated vascular permeability in rats. Involvement of the glucocorticoid receptor and vascular permeability factor. J Clin Invest 98(6):1400\u20131408. https:\/\/doi.org\/10.1172\/JCI118927","journal-title":"J Clin Invest"},{"key":"2113_CR41","doi-asserted-by":"publisher","DOI":"10.4014\/jmb.2411.11040","volume":"35","author":"W Hongxi","year":"2025","unstructured":"Hongxi W, Ruting W, Yiyang L, Qinglian H, Jibing C, Feng J (2025) Human brain organoids: development and applications. J Microbiol Biotechnol 35:e2411040. https:\/\/doi.org\/10.4014\/jmb.2411.11040","journal-title":"J Microbiol Biotechnol"},{"key":"2113_CR42","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-021-00791-1","volume":"6","author":"X Hu","year":"2021","unstructured":"Hu X, li J, Fu M et al (2021) The JAK\/STAT signaling pathway: from bench to clinic. Sig Transduct Target Ther 6:402. https:\/\/doi.org\/10.1038\/s41392-021-00791-1","journal-title":"Sig Transduct Target Ther"},{"issue":"1","key":"2113_CR43","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-53414-9","volume":"9","author":"T Hyv\u00e4rinen","year":"2019","unstructured":"Hyv\u00e4rinen T, Hagman S, Ristola M, Sukki L, Veijula K, Kreutzer J, Kallio P, Narkilahti S (2019) Co-stimulation with IL-1\u03b2 and TNF-\u03b1 induces an inflammatory reactive astrocyte phenotype with neurosupportive characteristics in a human pluripotent stem cell model system. Sci Rep 9(1):16944. https:\/\/doi.org\/10.1038\/s41598-019-53414-9","journal-title":"Sci Rep"},{"issue":"1","key":"2113_CR44","first-page":"01","volume":"5","author":"P Jain","year":"2013","unstructured":"Jain P, Surana A, Pandey R, Shukla SS (2013) Epilepsy: a neurological cramp, research. J Pharmacol Pharmacodyn 5(1):01\u201305","journal-title":"J Pharmacol Pharmacodyn"},{"key":"2113_CR46","first-page":"25","volume-title":"Inflammation: natural resources and its applications","author":"P Jain","year":"2015","unstructured":"Jain P, Pandey R, Shukla SS (2015) Natural Sources of Anti-inflammation. In: Jain P, Pandey R, Shukla SS (eds) Inflammation: natural resources and its applications. Springer, New Delhi, India, pp 25\u2013133"},{"key":"2113_CR47","volume":"12","author":"A Jain","year":"2024","unstructured":"Jain A, Jain P, Mathur S, Parihar DK (2024a) Curcuma species DNA fingerprinting of wild and cultivated genotypes from different agroclimatic zones. Pharmacol Res 12:100474","journal-title":"Pharmacol Res"},{"issue":"2","key":"2113_CR48","doi-asserted-by":"publisher","first-page":"40","DOI":"10.5281\/zenodo.14634757","volume":"1","author":"A Jain","year":"2024","unstructured":"Jain A, Tiwary B, Bajaj S (2024b) Development of HPTLC fingerprint of Curcuma longa collected from different geographical locations of Chhattisgarh for quantification of curcumin. Prob Sci 1(2):40\u201345. https:\/\/doi.org\/10.5281\/zenodo.14634757","journal-title":"Prob Sci"},{"issue":"6","key":"2113_CR49","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinre.2025.102584","volume":"49","author":"P Jain","year":"2025","unstructured":"Jain P, Jain A, Deshmukh R, Samal P, Satapathy T (2025) Metabolic dysfunction-associated steatotic liver disease (MASLD): exploring systemic impacts and innovative therapies. Clin Res Hepatol Gastroenterol 49(6):102584","journal-title":"Clin Res Hepatol Gastroenterol"},{"issue":"1","key":"2113_CR50","doi-asserted-by":"publisher","DOI":"10.3390\/jcm9010257","volume":"9","author":"W Jin","year":"2020","unstructured":"Jin W (2020) Regulation of BDNF-TrkB signaling and potential therapeutic strategies for Parkinson\u2019s disease. J Clin Med 9(1):257. https:\/\/doi.org\/10.3390\/jcm9010257","journal-title":"J Clin Med"},{"key":"2113_CR51","doi-asserted-by":"publisher","first-page":"5455","DOI":"10.1523\/JNEUROSCI.23-13-05455.2003","volume":"23","author":"SJ Kang","year":"2003","unstructured":"Kang SJ, Sanchez I, Jing N, Yuan J (2003) Dissociation between neurodegeneration and caspase-11-mediated activation of caspase-1 and caspase-3 in a mouse model of amyotrophic lateral sclerosis. J Neurosci 23:5455\u20135460","journal-title":"J Neurosci"},{"key":"2113_CR52","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2025.156974","volume":"192","author":"R Kaur","year":"2025","unstructured":"Kaur R, Kumar S, Singh L (2025) A comprehensive review: neuroinflammation and immune communication between the central nervous system and the periphery. Cytokine 192:156974","journal-title":"Cytokine"},{"issue":"13","key":"2113_CR53","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20133328","volume":"20","author":"N Kelley","year":"2019","unstructured":"Kelley N, Jeltema D, Duan Y, He Y (2019) The NLRP3 inflammasome: an overview of mechanisms of activation and regulation. Int J Mol Sci 20(13):3328. https:\/\/doi.org\/10.3390\/ijms20133328","journal-title":"Int J Mol Sci"},{"key":"2113_CR54","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2019.01336","volume":"10","author":"BJ Kim","year":"2019","unstructured":"Kim BJ, Shusta EV, Doran KS (2019) Past and current perspectives in modeling bacteria and blood-brain barrier interactions. Front Microbiol 10:1336","journal-title":"Front Microbiol"},{"issue":"11","key":"2113_CR55","doi-asserted-by":"publisher","first-page":"1424","DOI":"10.3390\/cells8111424","volume":"8","author":"S Kuhn","year":"2019","unstructured":"Kuhn S, Gritti L, Crooks D, Dombrowski Y (2019) Oligodendrocytes in development, myelin generation and Beyond. Cells 8(11):1424","journal-title":"Cells"},{"key":"2113_CR56","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2021.155582","volume":"144","author":"KK Kummer","year":"2021","unstructured":"Kummer KK, Zeidler M, Kalpachidou T, Kress M (2021) Role of IL-6 in the regulation of neuronal development, survival and function. Cytokine 144:155582","journal-title":"Cytokine"},{"key":"2113_CR57","first-page":"1","volume":"20","author":"UC Kuwar","year":"2024","unstructured":"Kuwar UC, Pradhan M, Dhote NS, Patel R, Sinha A, Jain P (2024) Novel approaches and applications of nanotechnology in the delivery of topical drugs for psoriasis via nanocarriers. Curr Nanosci 20:1\u201327","journal-title":"Curr Nanosci"},{"issue":"7","key":"2113_CR58","doi-asserted-by":"publisher","DOI":"10.1002\/cti2.1404","volume":"11","author":"S Lara-Reyna","year":"2022","unstructured":"Lara-Reyna S, Caseley EA, Topping J, Rodrigues F, Jimenez Macias J, Lawler SE, McDermott MF (2022) Inflammasome activation: from molecular mechanisms to autoinflammation. Clin Transl Immunol 11(7):e1404. https:\/\/doi.org\/10.1002\/cti2.1404","journal-title":"Clin Transl Immunol"},{"key":"2113_CR59","doi-asserted-by":"publisher","first-page":"1077204","DOI":"10.3389\/fncel.2023.1077204","volume":"17","author":"LY Li","year":"2023","unstructured":"Li LY, Kreye J, Burek M, Cordero-Gomez C, Barthel PC, S\u00e1nchez-Send\u00edn E, Kornau HC, Schmitz D, Scharf M, Meybohm P et al (2023) Brain blood vessel autoantibodies in patients with NMDA and GABAA receptor encephalitis: Identification of unconventional Myosin-X as target antigen. Front Cell Neurosci 17:1077204","journal-title":"Front Cell Neurosci"},{"issue":"3","key":"2113_CR60","doi-asserted-by":"publisher","first-page":"1162757","DOI":"10.3389\/fnetp.2023.1162757","volume":"3","author":"A Lia","year":"2023","unstructured":"Lia A, Di Spiezio A, Speggiorin M, Zonta M (2023) Two decades of astrocytes in neurovascular coupling. Front Netw Physiol 3(3):1162757","journal-title":"Front Netw Physiol"},{"issue":"15","key":"2113_CR61","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202004433","volume":"8","author":"C Liu","year":"2021","unstructured":"Liu C, Chu D, Kalantar-Zadeh K, George J, Young HA, Liu G (2021) Cytokines: from clinical significance to quantification. Adv Sci 8(15):e2004433. https:\/\/doi.org\/10.1002\/advs.202004433","journal-title":"Adv Sci"},{"issue":"5","key":"2113_CR62","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0232612","volume":"15","author":"J Lokau","year":"2020","unstructured":"Lokau J, Kleinegger F, Garbers Y, Waetzig GH, Gr\u00f6tzinger J, Rose-John S, Haybaeck J, Garbers C (2020) Tocilizumab does not block interleukin-6 (IL-6) signaling in murine cells. PLoS ONE 15(5):e0232612. https:\/\/doi.org\/10.1371\/journal.pone.0232612","journal-title":"PLoS ONE"},{"issue":"5","key":"2113_CR63","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines10051206","volume":"10","author":"J Luo","year":"2022","unstructured":"Luo J (2022) TGF-\u03b2 as a key modulator of astrocyte reactivity: disease relevance and therapeutic implications. Biomedicines 10(5):1206. https:\/\/doi.org\/10.3390\/biomedicines10051206","journal-title":"Biomedicines"},{"key":"2113_CR64","doi-asserted-by":"publisher","DOI":"10.1177\/1744806916636385","volume":"12","author":"X Luo","year":"2016","unstructured":"Luo X, Tai WL, Sun L, Pan Z, Xia Z, Chung SK, Cheung CW (2016) Crosstalk between astrocytic CXCL12 and microglial CXCR4 contributes to the development of neuropathic pain. Mol Pain 12:1744806916636385. https:\/\/doi.org\/10.1177\/1744806916636385","journal-title":"Mol Pain"},{"key":"2113_CR65","doi-asserted-by":"publisher","DOI":"10.1177\/1179069518793639","volume":"12","author":"DI Lurie","year":"2018","unstructured":"Lurie DI (2018) An integrative approach to neuroinflammation in psychiatric disorders and neuropathic pain. J Exp Neurosci 12:1179069518793639. https:\/\/doi.org\/10.1177\/1179069518793639","journal-title":"J Exp Neurosci"},{"issue":"785","key":"2113_CR66","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.adm7269","volume":"17","author":"F Ma","year":"2025","unstructured":"Ma F, Liu X, Zhang Y, Tao Y, Zhao L, Abusalamah H, Huffman C, Harbison RA, Puram SV, Wang Y, Peng G (2025) Tumor extracellular vesicle-derived PD-L1 promotes T cell senescence through lipid metabolism reprogramming. Sci Transl Med 17(785):eadm7269. https:\/\/doi.org\/10.1126\/scitranslmed.adm7269","journal-title":"Sci Transl Med"},{"key":"2113_CR67","doi-asserted-by":"publisher","first-page":"118","DOI":"10.1016\/j.neuroscience.2018.10.030","volume":"405","author":"G Manich","year":"2019","unstructured":"Manich G, Recasens M, Valente T, Almolda B, Gonz\u00e1lez B, Castellano B (2019) Role of the CD200-CD200R axis during homeostasis and neuroinflammation. Neuroscience 405:118\u2013136","journal-title":"Neuroscience"},{"issue":"9","key":"2113_CR68","doi-asserted-by":"publisher","DOI":"10.3390\/molecules21091243","volume":"21","author":"G Mazzanti","year":"2016","unstructured":"Mazzanti G, Di Giacomo S (2016) Curcumin and resveratrol in the management of cognitive disorders: what is the clinical evidence? Molecules 21(9):1243. https:\/\/doi.org\/10.3390\/molecules21091243","journal-title":"Molecules"},{"key":"2113_CR69","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1007\/978-1-0716-2289-6_1","volume":"2492","author":"HL McConnell","year":"2022","unstructured":"McConnell HL, Mishra A (2022) Cells of the blood-brain barrier: an overview of the neurovascular unit in health and disease. Methods Mol Biol 2492:3\u201324. https:\/\/doi.org\/10.1007\/978-1-0716-2289-6_1","journal-title":"Methods Mol Biol"},{"key":"2113_CR70","doi-asserted-by":"crossref","unstructured":"Milatovic D, Zaja-Milatovic S, Breyer RM, Aschner M, Montine TJ (2017) Chapter 55: neuroinflammation and oxidative injury in developmental neurotoxicity. In: Gupta RCBTR and DT (Second E, editor. Academic Press; 2017. p. 1051\u201361. Available from: https:\/\/www.sciencedirect.com\/science\/article\/pii\/B978012804239700055X","DOI":"10.1016\/B978-0-12-804239-7.00055-X"},{"issue":"2","key":"2113_CR71","doi-asserted-by":"publisher","first-page":"101","DOI":"10.3390\/genes4020101","volume":"4","author":"U Moens","year":"2013","unstructured":"Moens U, Kostenko S, Sveinbj\u00f8rnsson B (2013) The role of mitogen-activated protein kinase-activated protein kinases (MAPKAPKs) in inflammation. Genes 4(2):101\u2013133. https:\/\/doi.org\/10.3390\/genes4020101","journal-title":"Genes"},{"key":"2113_CR72","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3897\/pharmacia.72.e146759","volume":"72","author":"M Moneva-Sakelarieva","year":"2025","unstructured":"Moneva-Sakelarieva M, Kobakova Y, Konstantinov S, Momekov G, Ivanova S, Atanasova V et al (2025) The role of the transcription factor NF-kB in the pathogenesis of inflammation and carcinogenesis. Modulation capabilities. Pharmacia 72:1\u201313","journal-title":"Pharmacia"},{"key":"2113_CR73","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2023.114680","volume":"455","author":"SJ Myers","year":"2023","unstructured":"Myers SJ, Agapova V, Patel SV, Hayes SH, Sposato LA, Allman BL et al (2023) Acute minocycline treatment inhibits microglia activation, reduces infarct volume, and has domain-specific effects on post-ischemic stroke cognition in rats. Behav Brain Res 455:114680","journal-title":"Behav Brain Res"},{"issue":"1","key":"2113_CR74","doi-asserted-by":"publisher","first-page":"443","DOI":"10.1146\/annurev-biophys-083012-130338","volume":"42","author":"J Napetschnig","year":"2013","unstructured":"Napetschnig J, Wu H (2013) Molecular basis of NF-\u03baB signaling. Annu Rev Biophys 42(1):443\u2013468. https:\/\/doi.org\/10.1146\/annurev-biophys-083012-130338","journal-title":"Annu Rev Biophys"},{"issue":"2","key":"2113_CR75","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1016\/j.cytogfr.2011.02.003","volume":"22","author":"MF Neurath","year":"2011","unstructured":"Neurath MF, Finotto S (2011) IL-6 signaling in autoimmunity, chronic inflammation and inflammation-associated cancer. Cytokine Growth Factor Rev 22(2):83\u201389","journal-title":"Cytokine Growth Factor Rev"},{"issue":"5","key":"2113_CR76","doi-asserted-by":"publisher","first-page":"837","DOI":"10.1016\/j.neuron.2019.12.007","volume":"105","author":"AA Nugent","year":"2020","unstructured":"Nugent AA, Lin K, van Lengerich B, Lianoglou S, Przybyla L, Davis SS, Llapashtica C, Wang J, Kim DJ, Xia D, Lucas A, Baskaran S, Haddick PCG, Lenser M, Earr TK, Shi J, Dugas JC, Andreone BJ, Logan T, Solanoy HO, Chen H, Srivastava A, Poda SB, Sanchez PE, Watts RJ, Sandmann T, Astarita G, Lewcock JW, Monroe KM, Di Paolo G (2020) TREM2 regulates microglial cholesterol metabolism upon chronic phagocytic challenge. Neuron 105(5):837-854.e9. https:\/\/doi.org\/10.1016\/j.neuron.2019.12.007","journal-title":"Neuron"},{"key":"2113_CR77","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/861231","volume":"2014","author":"G Olmos","year":"2014","unstructured":"Olmos G, Llad\u00f3 J (2014) Tumor necrosis factor alpha: a link between neuroinflammation and excitotoxicity. Mediators Inflamm 2014:861231. https:\/\/doi.org\/10.1155\/2014\/861231","journal-title":"Mediators Inflamm"},{"issue":"4","key":"2113_CR78","doi-asserted-by":"publisher","first-page":"1162","DOI":"10.1378\/chest.117.4.1162","volume":"117","author":"SM Opal","year":"2000","unstructured":"Opal SM, DePalo VA (2000) Anti-inflammatory cytokines. Chest 117(4):1162\u20131172","journal-title":"Chest"},{"key":"2113_CR79","doi-asserted-by":"crossref","unstructured":"Pandey RK, Jain P, Shukla SS, Gidwani B, Jain A (2024) Ethnomedicinal value of medicinal plants found in chhattisgarh\u202f: recent scenario and advancement. Curr Tradit Med 1\u20139","DOI":"10.2174\/0122150838278588240123084611"},{"issue":"1","key":"2113_CR80","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-023-01608-z","volume":"8","author":"V Panwar","year":"2023","unstructured":"Panwar V, Singh A, Bhatt M, Tonk RK, Azizov S, Raza AS, Sengupta S, Kumar D, Garg M (2023) Multifaceted role of mTOR (mammalian target of rapamycin) signaling pathway in human health and disease. Signal Transduct Target Ther 8(1):375. https:\/\/doi.org\/10.1038\/s41392-023-01608-z","journal-title":"Signal Transduct Target Ther"},{"key":"2113_CR81","first-page":"1","volume":"20","author":"A Patel","year":"2024","unstructured":"Patel A, Jain P, Thakur A, Ajazuddin, (2024) Recent review of herbs and medicinal plant-based nanotechnological approach in treating psoriasis. Curr Bioact Comp 20:1\u201318","journal-title":"Curr Bioact Comp"},{"key":"2113_CR82","doi-asserted-by":"publisher","first-page":"193","DOI":"10.2174\/1567201820666230112170035","volume":"21","author":"R Patel","year":"2024","unstructured":"Patel R, Kuwar U, Dhote N, Alexander A, Nakhate K, Jain P et al (2024) Natural polymers as a carrier for the effective delivery of antineoplastic drugs. Curr Drug Deliv 21:193\u2013210","journal-title":"Curr Drug Deliv"},{"issue":"5","key":"2113_CR83","doi-asserted-by":"publisher","first-page":"311","DOI":"10.1016\/S0301-0082(02)00128-4","volume":"68","author":"MA Petty","year":"2002","unstructured":"Petty MA, Lo EH (2002) Junctional complexes of the blood\u2013brain barrier: permeability changes in neuroinflammation. Prog Neurobiol 68(5):311\u2013323","journal-title":"Prog Neurobiol"},{"issue":"13","key":"2113_CR84","doi-asserted-by":"publisher","first-page":"5214","DOI":"10.1074\/jbc.RA118.005828","volume":"294","author":"SM Pontejo","year":"2019","unstructured":"Pontejo SM, Sanchez C, Ruiz-Arg\u00fcello B, Alcami A (2019) Insights into ligand binding by a viral tumor necrosis factor (TNF) decoy receptor yield a selective soluble human type 2 TNF receptor. J Biol Chem 294(13):5214\u20135227. https:\/\/doi.org\/10.1074\/jbc.RA118.005828","journal-title":"J Biol Chem"},{"key":"2113_CR85","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-024-06559-z","volume":"15","author":"MK Preedy","year":"2024","unstructured":"Preedy MK, White MRH, Tergaonkar V (2024) Cellular heterogeneity in TNF\/TNFR1 signalling: live cell imaging of cell fate decisions in single cells. Cell Death Dis 15:202. https:\/\/doi.org\/10.1038\/s41419-024-06559-z","journal-title":"Cell Death Dis"},{"issue":"1","key":"2113_CR86","doi-asserted-by":"publisher","DOI":"10.1093\/bioadv\/vbae090","volume":"4","author":"BL Puniya","year":"2024","unstructured":"Puniya BL, Verma M, Damiani C, Bakr S, Dr\u00e4ger A (2024) Perspectives on computational modeling of biological systems and the significance of the SysMod community. Bioinform Adv 4(1):vbae090. https:\/\/doi.org\/10.1093\/bioadv\/vbae090","journal-title":"Bioinform Adv"},{"key":"2113_CR87","doi-asserted-by":"publisher","first-page":"2697","DOI":"10.1038\/s41380-023-02061-8","volume":"28","author":"K Qian","year":"2023","unstructured":"Qian K, Jiang X, Liu ZQ et al (2023) Revisiting the critical roles of reactive astrocytes in neurodegeneration. Mol Psychiatry 28:2697\u20132706. https:\/\/doi.org\/10.1038\/s41380-023-02061-8","journal-title":"Mol Psychiatry"},{"issue":"1","key":"2113_CR88","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1016\/j.neulet.2009.08.013","volume":"464","author":"Y Quan","year":"2009","unstructured":"Quan Y, M\u00f6ller T, Weinstein JR (2009) Regulation of Fc\u03b3 receptors and immunoglobulin G-mediated phagocytosis in mouse microglia. Neurosci Lett 464(1):29\u201333","journal-title":"Neurosci Lett"},{"key":"2113_CR89","first-page":"209","volume-title":"Pradhan M","author":"NGR Rao","year":"2024","unstructured":"Rao NGR, Majumdar A, Mishra S, Jain P, Jain A, Talath S et al (2024) Biomaterials in the design of nanosensors for disease diagnosis BT: biomaterial-inspired nanomedicines for targeted therapies. In: Yadav K, Singh Chauhan N (eds) Pradhan M. Springer, Singapore, pp 209\u2013236"},{"key":"2113_CR90","unstructured":"Rathore P, Rao SP, Roy A, Satapathy T, Singh V, Jain P (2014) Hepatoprotective activity of isolated herbal compounds. Res J Pharm Technol 7(2)"},{"key":"2113_CR91","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2024.124734","volume":"666","author":"MA Raza","year":"2024","unstructured":"Raza MA, Sharma MK, Nagori K, Jain P, Ghosh V, Gupta U (2024) Recent trends on polycaprolactone as sustainable polymer-based drug delivery system in the treatment of cancer: biomedical applications and nanomedicine. Int J Pharm 666:124734","journal-title":"Int J Pharm"},{"key":"2113_CR92","doi-asserted-by":"publisher","first-page":"121949","DOI":"10.1016\/j.biomaterials.2022.121949","volume":"293","author":"FU Rehman","year":"2023","unstructured":"Rehman FU, Liu Y, Zheng M, Shi B (2023) Exosomes based strategies for brain drug delivery. Biomaterials 293:121949","journal-title":"Biomaterials"},{"key":"2113_CR93","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/9259646","volume":"2016","author":"P Rider","year":"2016","unstructured":"Rider P, Carmi Y, Cohen I (2016) Biologics for targeting inflammatory cytokines, clinical uses, and limitations. Int J Cell Biol 2016:9259646. https:\/\/doi.org\/10.1155\/2016\/9259646","journal-title":"Int J Cell Biol"},{"issue":"6","key":"2113_CR94","doi-asserted-by":"publisher","first-page":"728","DOI":"10.1165\/rcmb.2006-0323OC","volume":"36","author":"A Saadane","year":"2007","unstructured":"Saadane A, Masters S, DiDonato J, Li J, Berger M (2007) Parthenolide inhibits IkappaB kinase, NF-kappaB activation, and inflammatory response in cystic fibrosis cells and mice. Am J Respir Cell Mol Biol 36(6):728\u2013736. https:\/\/doi.org\/10.1165\/rcmb.2006-0323OC","journal-title":"Am J Respir Cell Mol Biol"},{"key":"2113_CR95","first-page":"1","volume":"20","author":"N Sahu","year":"2024","unstructured":"Sahu N, Jain P, Nagori K (2024) Recent advancement and novel treatment strategies for breast fibroadenoma: clinical approach and prospects. Curr Cancer Ther Rev 20:1\u201311","journal-title":"Curr Cancer Ther Rev"},{"key":"2113_CR96","first-page":"1","volume":"15","author":"S Sahu","year":"2025","unstructured":"Sahu S, Ghosh V, Jain P (2025) Recent advancement of novel drug delivery systems for topical anaesthesia formulations. Curr Nanomed 15:1\u201317","journal-title":"Curr Nanomed"},{"key":"2113_CR97","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1007\/978-1-4939-7526-6_17","volume":"1717","author":"E Salvador","year":"2018","unstructured":"Salvador E, Burek M, F\u00f6rster CY (2018) An in vitro model of traumatic brain injury. Methods Mol Biol 1717:219\u2013227","journal-title":"Methods Mol Biol"},{"issue":"9","key":"2113_CR98","doi-asserted-by":"publisher","first-page":"e68807","DOI":"10.7759\/cureus.68807","volume":"16","author":"S Sangeetha","year":"2024","unstructured":"Sangeetha S, Narayanasamy D (2024) The science of solid lipid nanoparticles: from fundamentals to applications. Cureus. 16(9):e68807. https:\/\/doi.org\/10.7759\/cureus.68807","journal-title":"Cureus."},{"issue":"2","key":"2113_CR99","doi-asserted-by":"publisher","first-page":"126","DOI":"10.2174\/1570159X15666170703113212","volume":"16","author":"F Sarubbo","year":"2018","unstructured":"Sarubbo F, Esteban S, Miralles A, Moranta D (2018) Effects of resveratrol and other polyphenols on Sirt1: relevance to brain function during aging. Curr Neuropharmacol 16(2):126\u2013136. https:\/\/doi.org\/10.2174\/1570159X15666170703113212","journal-title":"Curr Neuropharmacol"},{"issue":"7","key":"2113_CR100","doi-asserted-by":"publisher","DOI":"10.3390\/cells11071139","volume":"11","author":"S Satarker","year":"2022","unstructured":"Satarker S, Bojja SL, Gurram PC, Mudgal J, Arora D, Nampoothiri M (2022) Astrocytic glutamatergic transmission and its implications in neurodegenerative disorders. Cells 11(7):1139. https:\/\/doi.org\/10.3390\/cells11071139","journal-title":"Cells"},{"issue":"10","key":"2113_CR101","doi-asserted-by":"publisher","first-page":"R453","DOI":"10.1016\/j.cub.2014.03.034","volume":"24","author":"M Schieber","year":"2014","unstructured":"Schieber M, Chandel NS (2014) ROS function in redox signaling and oxidative stress. Curr Biol 24(10):R453\u2013R462","journal-title":"Curr Biol"},{"key":"2113_CR102","first-page":"255","volume":"4","author":"L Schlotterose","year":"2023","unstructured":"Schlotterose L, Beldjilali-Labro M, Schneider G, Vardi O, Hattermann K, Even U, Shohami E, Haustein HD, Leichtmann- Bardoogo Y, Maoz BM (2023) Traumatic brain injury in a well: a modular three-dimensional printed tool for inducing traumatic brain injury in vitro. Neurotrauma Rep 4:255\u2013266","journal-title":"Neurotrauma Rep"},{"key":"2113_CR103","doi-asserted-by":"publisher","DOI":"10.1016\/j.foohum.2024.100462","volume":"3","author":"F Shah","year":"2024","unstructured":"Shah F, Nagaraj K, Kamalesu S, Radhakrishnan L, Venkatachalapathy R (2024) Advancing nutraceuticals in a promising frontier in modern healthcare. Food Human 3:100462","journal-title":"Food Human"},{"issue":"8","key":"2113_CR104","doi-asserted-by":"publisher","first-page":"1979","DOI":"10.1110\/ps.04789804","volume":"13","author":"Y Shi","year":"2004","unstructured":"Shi Y (2004) Caspase activation, inhibition, and reactivation: a mechanistic view. Protein Sci 13(8):1979\u20131987. https:\/\/doi.org\/10.1110\/ps.04789804","journal-title":"Protein Sci"},{"issue":"12","key":"2113_CR105","doi-asserted-by":"publisher","first-page":"1097","DOI":"10.1177\/1947601911423031","volume":"2","author":"M Shibuya","year":"2011","unstructured":"Shibuya M (2011) Vascular endothelial growth factor (VEGF) and its receptor (VEGFR) signaling in angiogenesis: a crucial target for anti- and pro-angiogenic therapies. Genes Cancer 2(12):1097\u20131105. https:\/\/doi.org\/10.1177\/1947601911423031","journal-title":"Genes Cancer"},{"issue":"6","key":"2113_CR106","doi-asserted-by":"publisher","first-page":"638","DOI":"10.3390\/brainsci15060638","volume":"15","author":"YW Shin","year":"2025","unstructured":"Shin YW, Hong SB, Lee SK (2025) Analysis of early EEG changes after tocilizumab treatment in new-onset refractory status epilepticus. Brain Sci 15(6):638","journal-title":"Brain Sci"},{"key":"2113_CR45","unstructured":"Singh R, Prasad J, Satapathy T, Jain P, Singh S. Pharmacological evaluation for anti-bacterial and anti-inflammatory potential of polymeric microparticles. 2021;58(April):156\u201361."},{"issue":"1","key":"2113_CR107","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-025-03435-1","volume":"22","author":"E Slowikowski","year":"2025","unstructured":"Slowikowski E, Willems C, Lemes RMR, Schuermans S, Berghmans N, Rocha RPF, Martens E, Proost P, Delang L, Marques RE, Filho JCA, Marques PE (2025) A central role for CCR2 in monocyte recruitment and blood-brain barrier disruption during Usutu virus encephalitis. J Neuroinflammation 22(1):107. https:\/\/doi.org\/10.1186\/s12974-025-03435-1","journal-title":"J Neuroinflammation"},{"issue":"1","key":"2113_CR108","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1016\/j.brainresbull.2011.10.004","volume":"87","author":"JA Smith","year":"2012","unstructured":"Smith JA, Das A, Ray SK, Banik NL (2012) Role of pro-inflammatory cytokines released from microglia in neurodegenerative diseases. Brain Res Bull 87(1):10\u201320. https:\/\/doi.org\/10.1016\/j.brainresbull.2011.10.004","journal-title":"Brain Res Bull"},{"key":"2113_CR109","doi-asserted-by":"publisher","first-page":"1","DOI":"10.2174\/1568009623666230803111718","volume":"24","author":"N Sudhir Dhote","year":"2024","unstructured":"Sudhir Dhote N, Dineshbhai Patel R, Kuwar U, Agrawal M, Alexander A, Jain P et al (2024) Application of thermoresponsive smart polymers based in situ gel as a novel carrier for tumor targeting. Curr Cancer Drug Targets 24:1\u201322","journal-title":"Curr Cancer Drug Targets"},{"issue":"6","key":"2113_CR110","doi-asserted-by":"publisher","first-page":"3150","DOI":"10.4049\/jimmunol.1201140","volume":"189","author":"H Sultana","year":"2012","unstructured":"Sultana H, Neelakanta G, Foellmer HG, Montgomery RR, Anderson JF, Koski RA, Medzhitov RM, Fikrig E (2012) Semaphorin 7A contributes to West Nile virus pathogenesis through TGF-\u03b21\/Smad6 signaling. J Immunol 189(6):3150\u20133158. https:\/\/doi.org\/10.4049\/jimmunol.1201140","journal-title":"J Immunol"},{"key":"2113_CR111","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1007\/978-3-642-13443-2_8","volume":"200","author":"S Sweitzer","year":"2011","unstructured":"Sweitzer S, De Leo J (2011) Propentofylline: glial modulation, neuroprotection, and alleviation of chronic pain. Handb Exp Pharmacol 200:235\u2013250. https:\/\/doi.org\/10.1007\/978-3-642-13443-2_8","journal-title":"Handb Exp Pharmacol"},{"key":"2113_CR112","doi-asserted-by":"crossref","unstructured":"Talath S, Wali AF, El-Tanani M, Al Aldhaheri Y, Jain P, Mottershead R (2025) An introduction to cell signalling pathways and their dysregulation in cancer BT: cell signaling pathways and their therapeutic implication in cancers. In: Rehman MU, Khan MS (eds) Springer, Singapore, pp 1\u201342","DOI":"10.1007\/978-981-96-2763-9_1"},{"issue":"21","key":"2113_CR113","doi-asserted-by":"publisher","first-page":"3800","DOI":"10.1021\/acschemneuro.4c00339","volume":"15","author":"R Tenchov","year":"2024","unstructured":"Tenchov R, Sasso JM, Zhou QA (2024) Alzheimer\u2019s disease: exploring the landscape of cognitive decline. ACS Chem Neurosci 15(21):3800\u20133827. https:\/\/doi.org\/10.1021\/acschemneuro.4c00339","journal-title":"ACS Chem Neurosci"},{"key":"2113_CR114","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/978-1-4939-9036-8_1","volume":"1930","author":"NK Verma","year":"2019","unstructured":"Verma NK, Kelleher D (2019) An introduction to LFA-1\/ICAM-1 interactions in T-cell motility. Methods Mol Biol 1930:1\u20139. https:\/\/doi.org\/10.1007\/978-1-4939-9036-8_1","journal-title":"Methods Mol Biol"},{"issue":"1","key":"2113_CR115","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-016-0631-6","volume":"13","author":"JY Wang","year":"2016","unstructured":"Wang JY, Huang YN, Chiu CC, Tweedie D, Luo W, Pick CG, Chou SY, Luo Y, Hoffer BJ, Greig NH, Wang JY (2016) Pomalidomide mitigates neuronal loss, neuroinflammation, and behavioral impairments induced by traumatic brain injury in rat. J Neuroinflammation 13(1):168. https:\/\/doi.org\/10.1186\/s12974-016-0631-6","journal-title":"J Neuroinflammation"},{"key":"2113_CR116","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2023.115973","volume":"220","author":"J Wang","year":"2024","unstructured":"Wang J, Liu Y, Guo Y, Liu C, Yang Y, Fan X et al (2024) Function and inhibition of P38 MAP kinase signaling: Targeting multiple inflammation diseases. Biochem Pharmacol 220:115973","journal-title":"Biochem Pharmacol"},{"issue":"6","key":"2113_CR117","doi-asserted-by":"publisher","first-page":"1755","DOI":"10.1016\/S0002-9440(10)65431-4","volume":"154","author":"M Watari","year":"1999","unstructured":"Watari M, Watari H, DiSanto ME, Chacko S, Shi GP, Strauss JF 3rd (1999) Pro-inflammatory cytokines induce expression of matrix-metabolizing enzymes in human cervical smooth muscle cells. Am J Pathol 154(6):1755\u20131762. https:\/\/doi.org\/10.1016\/S0002-9440(10)65431-4","journal-title":"Am J Pathol"},{"issue":"24","key":"2113_CR118","doi-asserted-by":"publisher","DOI":"10.3390\/ijms222413397","volume":"22","author":"K Wicherska-Paw\u0142owska","year":"2021","unstructured":"Wicherska-Paw\u0142owska K, Wr\u00f3bel T, Rybka J (2021) Toll-like receptors (TLRs), nod-like receptors (NLRs), and RIG-I-like receptors (RLRs) in innate immunity. TLRs, NLRs, and RLRs ligands as immunotherapeutic agents for hematopoietic diseases. Int J Mol Sci 22(24):13397. https:\/\/doi.org\/10.3390\/ijms222413397","journal-title":"Int J Mol Sci"},{"issue":"19","key":"2113_CR119","doi-asserted-by":"publisher","first-page":"11357","DOI":"10.2147\/IJN.S484838","volume":"6","author":"G Wilar","year":"2024","unstructured":"Wilar G, Suhandi C, Wathoni N, Fukunaga K, Kawahata I (2024) Nanoparticle-based drug delivery systems enhance treatment of cognitive defects. Int J Nanomed 6(19):11357\u201311378","journal-title":"Int J Nanomed"},{"issue":"1","key":"2113_CR120","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics13010015","volume":"13","author":"SK Wu","year":"2020","unstructured":"Wu SK, Tsai CL, Huang Y, Hynynen K (2020) Focused ultrasound and microbubbles-mediated drug delivery to brain tumor. Pharmaceutics 13(1):15. https:\/\/doi.org\/10.3390\/pharmaceutics13010015","journal-title":"Pharmaceutics"},{"issue":"12","key":"2113_CR121","doi-asserted-by":"publisher","DOI":"10.3390\/ijms26125843","volume":"26","author":"Y Xiang","year":"2025","unstructured":"Xiang Y, Gu Q, Liu D (2025) Brain endothelial cells in blood-brain barrier regulation and neurological therapy. Int J Mol Sci 26(12):5843. https:\/\/doi.org\/10.3390\/ijms26125843","journal-title":"Int J Mol Sci"},{"key":"2113_CR122","doi-asserted-by":"publisher","first-page":"341","DOI":"10.1038\/s41423-025-01275-w","volume":"22","author":"W Xu","year":"2025","unstructured":"Xu W, Huang Y, Zhou R (2025) Nlrp3 inflammasome in neuroinflammation and central nervous system diseases. Cell Mol Immunol 22:341\u2013355. https:\/\/doi.org\/10.1038\/s41423-025-01275-w","journal-title":"Cell Mol Immunol"},{"issue":"12","key":"2113_CR123","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22126282","volume":"22","author":"G Yamanaka","year":"2021","unstructured":"Yamanaka G, Ishida Y, Kanou K, Suzuki S, Watanabe Y, Takamatsu T, Morichi S, Go S, Oana S, Yamazaki T, Kawashima H (2021) Towards a treatment for neuroinflammation in epilepsy: interleukin-1 receptor antagonist, anakinra, as a potential treatment in intractable epilepsy. Int J Mol Sci 22(12):6282. https:\/\/doi.org\/10.3390\/ijms22126282","journal-title":"Int J Mol Sci"},{"issue":"4","key":"2113_CR124","doi-asserted-by":"publisher","first-page":"833","DOI":"10.3233\/JAD-2009-1030","volume":"16","author":"SD Yan","year":"2009","unstructured":"Yan SD, Bierhaus A, Nawroth PP, Stern DM (2009) RAGE and Alzheimer\u2019s disease: a progression factor for amyloid-beta-induced cellular perturbation? J Alzheimers Dis 16(4):833\u2013843. https:\/\/doi.org\/10.3233\/JAD-2009-1030","journal-title":"J Alzheimers Dis"},{"key":"2113_CR125","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1016\/j.clim.2016.09.014","volume":"189","author":"Z Yan","year":"2018","unstructured":"Yan Z, Gibson SA, Buckley JA, Qin H, Benveniste EN (2018) Role of the JAK\/STAT signaling pathway in regulation of innate immunity in neuroinflammatory diseases. Clin Immunol 189:4\u201313. https:\/\/doi.org\/10.1016\/j.clim.2016.09.014","journal-title":"Clin Immunol"},{"issue":"3","key":"2113_CR126","doi-asserted-by":"publisher","DOI":"10.3390\/nu12030749","volume":"12","author":"ZH Yang","year":"2020","unstructured":"Yang ZH, Amar M, Sampson M, Courville AB, Sorokin AV, Gordon SM, Aponte AM, Stagliano M, Playford MP, Fu YP, Yang S, Mehta NN, Remaley AT (2020) Comparison of omega-3 eicosapentaenoic acid versus docosahexaenoic acid-rich fish oil supplementation on plasma lipids and lipoproteins in normolipidemic adults. Nutrients 12(3):749. https:\/\/doi.org\/10.3390\/nu12030749","journal-title":"Nutrients"},{"issue":"45","key":"2113_CR127","doi-asserted-by":"publisher","first-page":"32314","DOI":"10.1074\/jbc.M113.501668","volume":"288","author":"Y Yu","year":"2013","unstructured":"Yu Y, Sch\u00fcrpf T, Springer TA (2013) How natalizumab binds and antagonizes \u03b14 integrins. J Biol Chem 288(45):32314\u201332325. https:\/\/doi.org\/10.1074\/jbc.M113.501668","journal-title":"J Biol Chem"},{"key":"2113_CR128","unstructured":"Zafar S, Yaddanapudi SS (2025) Parkinson Disease. [Updated 2023 Aug 7]. In: StatPearls. Treasure Island (FL): StatPearls Publishing; 2025 Jan-. Available from: https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK470193\/"},{"issue":"10","key":"2113_CR129","doi-asserted-by":"publisher","first-page":"810","DOI":"10.1002\/cm.21055","volume":"69","author":"X Zhang","year":"2012","unstructured":"Zhang X, Bedigian AV, Wang W, Eggert US (2012) G protein-coupled receptors participate in cytokinesis. Cytoskeleton 69(10):810\u2013818. https:\/\/doi.org\/10.1002\/cm.21055","journal-title":"Cytoskeleton"},{"key":"2113_CR130","doi-asserted-by":"publisher","first-page":"7087","DOI":"10.3390\/ijms24087087","volume":"24","author":"B Zhang","year":"2023","unstructured":"Zhang B, Li X, Tang K, Xin Y, Hu G, Zheng Y, Li K, Zhang C, Tan Y (2023a) Adhesion to the brain endothelium selects breast cancer cells with brain metastasis potential. Int J Mol Sci 24:7087","journal-title":"Int J Mol Sci"},{"key":"2113_CR131","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-023-01486-5","volume":"8","author":"W Zhang","year":"2023","unstructured":"Zhang W, Xiao D, Mao Q et al (2023b) Role of neuroinflammation in neurodegeneration development. Sig Transduct Target Ther 8:267. https:\/\/doi.org\/10.1038\/s41392-023-01486-5","journal-title":"Sig Transduct Target Ther"},{"key":"2113_CR132","doi-asserted-by":"publisher","first-page":"588","DOI":"10.1038\/s44222-024-00207-z","volume":"2","author":"Y Zhao","year":"2024","unstructured":"Zhao Y, Landau S, Okhovatian S et al (2024) Integrating organoids and organ-on-a-chip devices. Nat Rev Bioeng 2:588\u2013608. https:\/\/doi.org\/10.1038\/s44222-024-00207-z","journal-title":"Nat Rev Bioeng"},{"key":"2113_CR133","doi-asserted-by":"publisher","first-page":"1317","DOI":"10.1002\/glia.24175","volume":"70","author":"X Zheng","year":"2022","unstructured":"Zheng X et al (2022) Progranulin deficiency promotes persistent neuroinflammation and causes regional pathology in the hippocampus following traumatic brain injury. Glia 70:1317\u20131336","journal-title":"Glia"},{"issue":"11","key":"2113_CR134","doi-asserted-by":"publisher","DOI":"10.1002\/ardp.202400459","volume":"357","author":"Y Zheng","year":"2024","unstructured":"Zheng Y, Zhang X, Wang Z, Zhang R, Wei H, Yan X, Jiang X, Yang L (2024) Mcc950 as a promising candidate for blocking NLRP3 inflammasome activation: a review of preclinical research and future directions. Arch Pharm Weinheim 357(11):e2400459. https:\/\/doi.org\/10.1002\/ardp.202400459","journal-title":"Arch Pharm Weinheim"},{"key":"2113_CR135","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-024-52061-7","volume":"15","author":"G Zhou","year":"2024","unstructured":"Zhou G, Rusnac DV, Park H et al (2024) An artificial intelligence accelerated virtual screening platform for drug discovery. Nat Commun 15:7761. https:\/\/doi.org\/10.1038\/s41467-024-52061-7","journal-title":"Nat Commun"},{"issue":"5","key":"2113_CR136","doi-asserted-by":"publisher","first-page":"914","DOI":"10.1016\/j.immuni.2023.04.011","volume":"56","author":"F Zipp","year":"2023","unstructured":"Zipp F, Bittner S, Schafer DP (2023) Cytokines as emerging regulators of central nervous system synapses. Immunity 56(5):914\u2013925. https:\/\/doi.org\/10.1016\/j.immuni.2023.04.011","journal-title":"Immunity"}],"container-title":["Inflammopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10787-026-02113-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10787-026-02113-9","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10787-026-02113-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T20:04:56Z","timestamp":1773777896000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10787-026-02113-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,19]]},"references-count":136,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,3]]}},"alternative-id":["2113"],"URL":"https:\/\/doi.org\/10.1007\/s10787-026-02113-9","relation":{},"ISSN":["0925-4692","1568-5608"],"issn-type":[{"value":"0925-4692","type":"print"},{"value":"1568-5608","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2,19]]},"assertion":[{"value":"3 September 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 December 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 February 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declared no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}