{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T18:22:49Z","timestamp":1793816569508,"version":"4.6.1"},"reference-count":62,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2026,2,14]],"date-time":"2026-02-14T00:00:00Z","timestamp":1771027200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,2,14]],"date-time":"2026-02-14T00:00:00Z","timestamp":1771027200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"name":"Haryana State Council for Science, Innovation & Technology","award":["HSCSIT\/R&D\/2022\/2954"],"award-info":[{"award-number":["HSCSIT\/R&D\/2022\/2954"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Inflammopharmacol"],"published-print":{"date-parts":[[2026,3]]},"DOI":"10.1007\/s10787-026-02123-7","type":"journal-article","created":{"date-parts":[[2026,2,14]],"date-time":"2026-02-14T15:26:57Z","timestamp":1771082817000},"page":"1751-1761","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Fructooligosaccharide ameliorates inflammation-induced chronic pain via deactivation of LPS\/TLR-4\/NF-\u03baB p65\/TNF-\u03b1\/IL-6 pathway in estrogen-deficient rats"],"prefix":"10.1007","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7835-7371","authenticated-orcid":false,"given":"Rishabh","family":"Chaudhary","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheenam","family":"Sharma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nitin","family":"Bansal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reena V.","family":"Saini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sumeet","family":"Gupta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kanwaljit","family":"Chopra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2889-0004","authenticated-orcid":false,"given":"Seema","family":"Bansal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,2,14]]},"reference":[{"issue":"11","key":"2123_CR1","doi-asserted-by":"publisher","first-page":"4382","DOI":"10.1007\/s13197-020-04922-4","volume":"58","author":"M Agrawal","year":"2021","unstructured":"Agrawal M, Bansal S, Chopra K (2021) Evaluation of the in vitro and in vivo antioxidant potentials of food grade phycocyanin. J Food Sci Technol 58(11):4382\u20134390","journal-title":"J Food Sci Technol"},{"key":"2123_CR2","doi-asserted-by":"publisher","first-page":"1680","DOI":"10.1038\/sj.ijo.0801806","volume":"25","author":"D Ainslie","year":"2001","unstructured":"Ainslie D, Morris M, Wittert G, Turnbull H, Proietto J, Thorburn A (2001) Estrogen deficiency causes central leptin insensitivity and increased hypothalamic neuropeptide Y. Int J Obes 25:1680\u20131688","journal-title":"Int J Obes"},{"key":"2123_CR3","doi-asserted-by":"publisher","first-page":"152","DOI":"10.1016\/j.mce.2017.07.017","volume":"460","author":"S Bansal","year":"2018","unstructured":"Bansal S, Chopra K (2018) Selective ER-\u03b1 agonist alleviates vascular endothelial dysfunction in ovariectomized type 2 diabetic rats. Mol Cell Endocrinol 460:152\u2013161","journal-title":"Mol Cell Endocrinol"},{"key":"2123_CR4","doi-asserted-by":"publisher","first-page":"6046","DOI":"10.1111\/ejn.16512","volume":"60","author":"S Bansal","year":"2024","unstructured":"Bansal S, Swami R, Bansal N, Chaudhary R, Mahendiratta S, Kaur H, Chopra K, Medhi B (2024) Evidence-based neuroprotective potential of nonfeminizing estrogens: in vitro and in vivo studies. Eur J Neurosci 60:6046\u20136056","journal-title":"Eur J Neurosci"},{"key":"2123_CR5","doi-asserted-by":"publisher","first-page":"R169","DOI":"10.1530\/REP-17-0406","volume":"155","author":"K Bidne","year":"2018","unstructured":"Bidne K, Dickson M, Ross J, Baumgard L, Keating A (2018) Disruption of female reproductive function by endotoxins. Reproduction 155:R169\u2013R181","journal-title":"Reproduction"},{"key":"2123_CR6","unstructured":"Calderazzi G (2017) Optimization of the experimental settings for the study of estrogen action in inflammation"},{"key":"2123_CR7","doi-asserted-by":"publisher","DOI":"10.3390\/ijms251910732","volume":"25","author":"L Capirchio","year":"2024","unstructured":"Capirchio L, Rousseaux C, Dubuquoy C, Ouwehand AC, Maquet V, Modica S, Louis E, Desreumaux P, Tack J (2024) A synbiotic combining chitin\u2013glucan and Lactobacillus acidophilus NCFM induces a colonic molecular signature soothing intestinal pain and inflammation in an animal model of IBS. Int J Mol Sci 25:10732","journal-title":"Int J Mol Sci"},{"key":"2123_CR8","doi-asserted-by":"publisher","first-page":"1445","DOI":"10.1007\/s00394-015-0962-6","volume":"55","author":"F Capit\u00e1n-Ca\u00f1adas","year":"2016","unstructured":"Capit\u00e1n-Ca\u00f1adas F, Oc\u00f3n B, Aranda CJ, Anzola A, Su\u00e1rez MD, Zarzuelo A, de Medina FS, Mart\u00ednez-Augustin O (2016) Fructooligosaccharides exert intestinal anti-inflammatory activity in the CD4\u207aCD62L\u207a T cell transfer model of colitis in C57BL\/6J mice. Eur J Nutr 55:1445\u20131454","journal-title":"Eur J Nutr"},{"key":"2123_CR9","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1007\/s11481-025-10253-y","volume":"20","author":"R Chaudhary","year":"2025","unstructured":"Chaudhary R, Lal R, Bansal N, Garg N, Bishnoi M, Kondepudi KK, Saini VR, Gupta S, Chopra K, Bansal S (2025b) Gut microbiota dysbiosis and neuroimmune alterations in a postmenopausal-stress rat model. J Neuroimmune Pharmacol 20:96","journal-title":"J Neuroimmune Pharmacol"},{"key":"2123_CR10","doi-asserted-by":"crossref","unstructured":"Chaudhary R, Bansal N, Kaur A, Gupta S, Chopra K, Bansal S (2025) Gut microbiota metabolic axis dysfunction in estrogen deficient stressed rats. Naunyn Schmiedebergs Arch Pharmacol 1\u201319","DOI":"10.1007\/s00210-025-04399-y"},{"key":"2123_CR11","doi-asserted-by":"publisher","first-page":"398","DOI":"10.1016\/j.jep.2016.03.038","volume":"191","author":"L Chen","year":"2016","unstructured":"Chen L, Hu L, Zhao J, Hong H, Feng F, Qu W, Liu W (2016) Chotosan improves A\u03b21\u201342-induced cognitive impairment and neuroinflammatory and apoptotic responses through the inhibition of TLR-4\/NF-\u03baB signaling in mice. J Ethnopharmacol 191:398\u2013407","journal-title":"J Ethnopharmacol"},{"key":"2123_CR12","doi-asserted-by":"publisher","first-page":"403","DOI":"10.3389\/fnagi.2017.00403","volume":"9","author":"D Chen","year":"2017","unstructured":"Chen D, Yang X, Yang J, Lai G, Yong T, Tang X, Li Z, Shu Z, Wu Q, Jiang S, Wang S (2017) Prebiotic effect of fructooligosaccharides from Morinda officinalis on Alzheimer\u2019s disease in rodent models by targeting the microbiota\u2013gut\u2013brain axis. Front Aging Neurosci 9:403","journal-title":"Front Aging Neurosci"},{"key":"2123_CR13","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s13293-021-00364-5","volume":"12","author":"Q Chen","year":"2021","unstructured":"Chen Q, Zhang W, Sadana N, Chen X (2021) Estrogen receptors in pain modulation: cellular signaling. Biol Sex Differ 12:1\u201310","journal-title":"Biol Sex Differ"},{"key":"2123_CR14","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2019.153157","volume":"67","author":"L Chi","year":"2020","unstructured":"Chi L, Khan I, Lin Z, Zhang J, Lee MS, Leong W, Hsiao WW, Zheng Y (2020) Fructo-oligosaccharides from Morinda officinalis remodeled gut microbiota and alleviated depression features in a stress rat model. Phytomedicine 67:153157","journal-title":"Phytomedicine"},{"key":"2123_CR15","doi-asserted-by":"publisher","first-page":"S3","DOI":"10.1016\/j.pain.2007.09.028","volume":"132","author":"RM Craft","year":"2007","unstructured":"Craft RM (2007) Modulation of pain by estrogens. Pain 132:S3\u2013S12","journal-title":"Pain"},{"key":"2123_CR16","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1111\/jam.13765","volume":"125","author":"J Dhaliwal","year":"2018","unstructured":"Dhaliwal J, Singh D, Singh S, Pinnaka AK, Boparai R, Bishnoi M, Kondepudi K, Chopra K (2018) Lactobacillus plantarum MTCC 9510 supplementation protects from chronic unpredictable and sleep deprivation-induced behaviour, biochemical and selected gut microbial aberrations in mice. J Appl Microbiol 125:257\u2013269","journal-title":"J Appl Microbiol"},{"key":"2123_CR17","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1016\/j.freeradbiomed.2005.03.007","volume":"39","author":"Z Feng","year":"2005","unstructured":"Feng Z, Zhang J-T (2005) Long-term melatonin or 17\u03b2-estradiol supplementation alleviates oxidative stress in ovariectomized adult rats. Free Radic Biol Med 39:195\u2013204","journal-title":"Free Radic Biol Med"},{"key":"2123_CR18","doi-asserted-by":"publisher","DOI":"10.1111\/ejn.70164","volume":"61","author":"N Goyal","year":"2025","unstructured":"Goyal N, Chaudhary R, Aggarwal K, Kumar H, Bansal N, Gupta S, Bansal S (2025) Red clover supplementation alleviates neurological deficits in estrogen deficient rats exposed to chronic unpredictable mild stress. Eur J Neurosci 61:e70164","journal-title":"Eur J Neurosci"},{"key":"2123_CR19","doi-asserted-by":"publisher","DOI":"10.3389\/fnut.2021.805465","volume":"8","author":"F Huang","year":"2022","unstructured":"Huang F, Liu X, Xu S, Hu S, Wang S, Shi D, Wang K, Wang Z, Lin Q, Li S (2022) Prevotella histicola mitigated estrogen deficiency-induced depression via gut microbiota-dependent modulation of inflammation in ovariectomized mice. Front Nutr 8:805465","journal-title":"Front Nutr"},{"key":"2123_CR20","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2023.110239","volume":"119","author":"WW Ibrahim","year":"2023","unstructured":"Ibrahim WW, Skalicka-Wo\u017aniak K, Budzy\u0144ska B, El Sayed NS (2023) NLRP3 inflammasome inhibition and M1-to-M2 microglial polarization shifting via scoparone-inhibited TLR4 axis in ovariectomy\/D-galactose Alzheimer\u2019s disease rat model. Int Immunopharmacol 119:110239","journal-title":"Int Immunopharmacol"},{"key":"2123_CR21","doi-asserted-by":"publisher","first-page":"1694","DOI":"10.1111\/nmo.12450","volume":"26","author":"P Kannampalli","year":"2014","unstructured":"Kannampalli P, Pochiraju S, Chichlowski M, Berg B, Rudolph C, Bruckert M, Miranda A, Sengupta J (2014) Probiotic Lactobacillus rhamnosus GG (LGG) and prebiotic prevent neonatal inflammation-induced visceral hypersensitivity in adult rats. Neurogastroenterol Motil 26:1694\u20131704","journal-title":"Neurogastroenterol Motil"},{"key":"2123_CR22","doi-asserted-by":"publisher","first-page":"430","DOI":"10.3390\/biomedicines13020430","volume":"13","author":"EN Kerezoudi","year":"2025","unstructured":"Kerezoudi EN, Saxami G, Zervakis GI, Pletsa V, Brummer RJ, Kyriacou A, Rangel I (2025) Effects of in vitro fermented Pleurotus eryngii on intestinal barrier integrity and immunomodulation in a lipopolysaccharide-induced colonic model. Biomedicines 13:430","journal-title":"Biomedicines"},{"key":"2123_CR23","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1210\/en.2018-00709","volume":"160","author":"SV Koebele","year":"2019","unstructured":"Koebele SV, Palmer JM, Hadder B, Melikian R, Fox C, Strouse IM, DeNardo DF, George C, Daunis E, Nimer A (2019) Hysterectomy uniquely impacts spatial memory in a rat model: a role for the nonpregnant uterus in cognitive processes. Endocrinology 160:1\u201319","journal-title":"Endocrinology"},{"key":"2123_CR24","doi-asserted-by":"publisher","DOI":"10.1016\/j.tjnut.2024.07.009","author":"DK Lakshmanan","year":"2024","unstructured":"Lakshmanan DK, Ravichandran G, Elangovan A, Thilagar S (2024) Mechanisms and intervention of prebiotic foods in musculoskeletal health. J Nutr. https:\/\/doi.org\/10.1016\/j.tjnut.2024.07.009","journal-title":"J Nutr"},{"key":"2123_CR25","unstructured":"Li Y, Wang G-P, Hao Z, Huang J, Gao C-Z, Huang J-L, Li H-J (2022) Dietary fructooligosaccharides prevent obesity and regulate the gut microbiota in C57BL\/6 mice"},{"key":"2123_CR26","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2023.102659","volume":"62","author":"J Liang","year":"2023","unstructured":"Liang J, Gao Y, Feng Z, Zhang B, Na Z, Li D (2023) Reactive oxygen species and ovarian diseases: antioxidant strategies. Redox Biol 62:102659","journal-title":"Redox Biol"},{"key":"2123_CR27","doi-asserted-by":"crossref","unstructured":"Liaquat M, Minihane AM, Vauzour D, Pontifex MG (2025) The gut microbiota in menopause: Is there a role for prebiotic and probiotic solutions? Post Reprod Health 20533691251340491","DOI":"10.1177\/20533691251340491"},{"key":"2123_CR28","doi-asserted-by":"publisher","first-page":"7955","DOI":"10.1038\/s41598-025-92212-4","volume":"15","author":"C-Q Liu","year":"2025","unstructured":"Liu C-Q, Yang J, Ren H-F, Liao G-N, Yin Z, Gao S-L, Du Q-J, Yuan X-Z, Ullah H, Li K (2025) Diversity of intestinal microbiota and inflammatory cytokines after severe trauma. Sci Rep 15:7955","journal-title":"Sci Rep"},{"key":"2123_CR29","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1016\/j.steroids.2011.11.011","volume":"77","author":"Y Lu","year":"2012","unstructured":"Lu Y, Li Z, Li H-J, Du D, Wang L-P, Yu L-H, Burnstock G, Chen A, Ma B (2012) A comparative study of the effect of 17\u03b2-estradiol and estriol on peripheral pain behavior in rats. Steroids 77:241\u2013249","journal-title":"Steroids"},{"key":"2123_CR30","doi-asserted-by":"publisher","DOI":"10.3389\/fnmol.2016.00019","volume":"9","author":"O Lykhmus","year":"2016","unstructured":"Lykhmus O, Mishra N, Koval L, Kalashnyk O, Gergalova G, Uspenska K, Komisarenko S, Soreq H, Skok M (2016) Molecular mechanisms regulating LPS-induced inflammation in the brain. Front Mol Neurosci 9:19","journal-title":"Front Mol Neurosci"},{"key":"2123_CR31","doi-asserted-by":"publisher","first-page":"2659","DOI":"10.3390\/ijms26062659","volume":"26","author":"Q Ma","year":"2025","unstructured":"Ma Q, Du R, Long P, Sun K, Wang Y, Yang Y, Shen X, Gao L (2025) The protective effects of burdock fructooligosaccharide on preterm labor through its anti-inflammatory action. Int J Mol Sci 26:2659","journal-title":"Int J Mol Sci"},{"key":"2123_CR32","doi-asserted-by":"publisher","first-page":"10985","DOI":"10.1523\/JNEUROSCI.22-24-10985.2002","volume":"22","author":"AL Markowska","year":"2002","unstructured":"Markowska AL, Savonenko AV (2002) Effectiveness of estrogen replacement in restoration of cognitive function after long-term estrogen withdrawal in aging rats. J Neurosci 22:10985\u201310995","journal-title":"J Neurosci"},{"key":"2123_CR33","doi-asserted-by":"crossref","first-page":"S112","DOI":"10.4103\/0253-7613.49034","volume":"40","author":"R Mehra","year":"2008","unstructured":"Mehra R (2008) Estrogen therapy improves neuronal cytoarchitecture, apoptotic index and estrogen receptor regulation in hormone depleted adult and in aged rat hippocampus. Indian J Pharmacol 40:S112\u2013S142","journal-title":"Indian J Pharmacol"},{"key":"2123_CR34","doi-asserted-by":"publisher","first-page":"591","DOI":"10.3390\/nu6020591","volume":"6","author":"H Merino-Aguilar","year":"2014","unstructured":"Merino-Aguilar H, Arrieta-Baez D, Jim\u00e9nez-Estrada M, Magos-Guerrero G, Hern\u00e1ndez-Bautista RJ, Susunaga-Notario ADC, Hern\u00e1ndez-P\u00e9rez E, L\u00f3pez-D\u00edazguerrero NE, Almanza-P\u00e9rez JC, Blancas-Flores G (2014) Effect of fructooligosaccharides fraction from Psacalium decompositum on inflammation and dyslipidemia in rats with fructose-induced obesity. Nutrients 6:591\u2013604","journal-title":"Nutrients"},{"key":"2123_CR35","first-page":"273","volume":"14","author":"B Mohanty","year":"2024","unstructured":"Mohanty B (2024) Prebiotic fructooligosaccharides ameliorate the lipopolysaccharides-induced oxidative stress of mice brain. J Appl Pharm Sci 14:273\u2013279","journal-title":"J Appl Pharm Sci"},{"key":"2123_CR36","doi-asserted-by":"publisher","first-page":"794","DOI":"10.3390\/foods14050794","volume":"14","author":"D Mou","year":"2025","unstructured":"Mou D, Ding D, Pu J, Zhou P, Cao E, Zhang X, Lan J, Ye L, Wen W (2025) Effects of dietary pretreatment with all-trans lycopene on lipopolysaccharide-induced jejunal inflammation: a multi-pathway phenomenon. Foods 14:794","journal-title":"Foods"},{"key":"2123_CR37","doi-asserted-by":"publisher","first-page":"309","DOI":"10.3340\/jkns.2010.48.4.309","volume":"48","author":"SB Park","year":"2010","unstructured":"Park SB, Lee YJ, Chung CK (2010) Bone mineral density changes after ovariectomy in rats as an osteopenic model: stepwise description of double dorso-lateral approach. J Korean Neurosurg Soc 48:309","journal-title":"J Korean Neurosurg Soc"},{"key":"2123_CR38","doi-asserted-by":"publisher","first-page":"2734","DOI":"10.2174\/0929867321666140303123602","volume":"21","author":"M Pellegrini","year":"2014","unstructured":"Pellegrini M, Pallottini V, Marin R, Marino M (2014) Role of the sex hormone estrogen in the prevention of lipid disorder. Curr Med Chem 21:2734\u20132742","journal-title":"Curr Med Chem"},{"key":"2123_CR39","doi-asserted-by":"publisher","first-page":"5925","DOI":"10.1039\/D1FO04428A","volume":"13","author":"N Pengrattanachot","year":"2022","unstructured":"Pengrattanachot N, Thongnak L, Lungkaphin A (2022) The impact of prebiotic fructooligosaccharides on gut dysbiosis and inflammation in obesity and diabetes related kidney disease. Food Funct 13:5925\u20135945","journal-title":"Food Funct"},{"key":"2123_CR40","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-802761-5.00002-X","volume-title":"Acute and chronic inflammation induces disease pathogenesis","author":"C Ptaschinski","year":"2018","unstructured":"Ptaschinski C, Lukacs NW (2018) Acute and chronic inflammation induces disease pathogenesis. Elsevier, Mol Pathol"},{"issue":"4","key":"2123_CR41","doi-asserted-by":"publisher","first-page":"1998","DOI":"10.1007\/s12602-024-10320-5","volume":"17","author":"R Pujari","year":"2024","unstructured":"Pujari R, Jadhav D, Angal A, Syed J, Dubey AK (2024) Beneficial effect of synbiotic combination of Limosilactobacillus fermentum FS-10, Lactiplantibacillus plantarum Lp1-IC and short-chain fructooligosaccharides in colitis murine model. Probiotics Antimicrob Proteins 17(4):1998\u20132008","journal-title":"Probiotics Antimicrob Proteins"},{"issue":"4","key":"2123_CR42","doi-asserted-by":"publisher","first-page":"1251","DOI":"10.1007\/s12602-023-10109-y","volume":"16","author":"Z Rahman","year":"2023","unstructured":"Rahman Z, Bhale NA, Dikundwar AG, Dandekar MP (2023) Multistrain probiotics with fructooligosaccharides improve middle cerebral artery occlusion\u2013driven neurological deficits by revamping microbiota-gut-brain axis. Probiotics Antimicrob Proteins 16(4):1251\u20131269","journal-title":"Probiotics Antimicrob Proteins"},{"key":"2123_CR43","doi-asserted-by":"publisher","first-page":"453","DOI":"10.1006\/niox.1997.0157","volume":"1","author":"R Robert","year":"1997","unstructured":"Robert R, Spitzer JA (1997) Effects of female hormones (17\u03b2-estradiol and progesterone) on nitric oxide production by alveolar macrophages in rats. Nitric Oxide 1:453\u2013462","journal-title":"Nitric Oxide"},{"key":"2123_CR44","doi-asserted-by":"publisher","first-page":"1744","DOI":"10.1186\/1744-8069-10-10","volume":"10","author":"RS Sauer","year":"2014","unstructured":"Sauer RS, Hackel D, Morschel L, Sahlbach H, Wang Y, Mousa SA, Roewer N, Brack A, Rittner HL (2014) Toll-like receptor (TLR)-4 as a regulator of peripheral endogenous opioid-mediated analgesia in inflammation. Mol Pain 10:1744\u20138069","journal-title":"Mol Pain"},{"key":"2123_CR45","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1016\/j.phrs.2017.06.015","volume":"123","author":"DP Singh","year":"2017","unstructured":"Singh DP, Singh J, Boparai RK, Zhu J, Mantri S, Khare P, Khardori R, Kondepudi KK, Chopra K, Bishnoi M (2017) Isomalto-oligosaccharides, a prebiotic, functionally augment green tea effects against high fat diet-induced metabolic alterations via preventing gut dysbacteriosis in mice. Pharmacol Res 123:103\u2013113","journal-title":"Pharmacol Res"},{"key":"2123_CR46","doi-asserted-by":"publisher","first-page":"4548","DOI":"10.1039\/C9FO00881K","volume":"11","author":"P Singh","year":"2020","unstructured":"Singh P, Bansal S, Kuhad A, Kumar A, Chopra K (2020a) Naringenin ameliorates diabetic neuropathic pain by modulation of oxidative-nitrosative stress, cytokines and MMP-9 levels. Food Funct 11:4548\u20134560","journal-title":"Food Funct"},{"key":"2123_CR47","doi-asserted-by":"publisher","first-page":"18597","DOI":"10.1038\/s41598-020-75702-5","volume":"10","author":"S Singh","year":"2020","unstructured":"Singh S, Bhatia R, Khare P, Sharma S, Rajarammohan S, Bishnoi M, Bhadada SK, Sharma SS, Kaur J, Kondepudi KK (2020b) Anti-inflammatory Bifidobacterium strains prevent dextran sodium sulfate induced colitis and associated gut microbial dysbiosis in mice. Sci Rep 10:18597","journal-title":"Sci Rep"},{"key":"2123_CR48","doi-asserted-by":"publisher","first-page":"757","DOI":"10.1080\/01635580802192841","volume":"60","author":"CL Smith","year":"2008","unstructured":"Smith CL, Geier MS, Yazbeck R, Torres DM, Butler RN, Howarth GS (2008) Lactobacillus fermentum BR11 and fructo-oligosaccharide partially reduce jejunal inflammation in a model of intestinal mucositis in rats. Nutr Cancer 60:757\u2013767","journal-title":"Nutr Cancer"},{"key":"2123_CR49","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2021.701391","volume":"11","author":"CLSE Souza","year":"2021","unstructured":"Souza CLSE, Barbosa CD, Coelho HI, Santos J\u00fanior MN, Barbosa EN, Queiroz \u00c9C, Teles MF, dos Santos DC, Bittencourt RS, Soares TDJ (2021) Effects of 17\u03b2-estradiol on monocyte\/macrophage response to Staphylococcus aureus: an in vitro study. Front Cell Infect Microbiol 11:701391","journal-title":"Front Cell Infect Microbiol"},{"key":"2123_CR50","doi-asserted-by":"publisher","first-page":"182","DOI":"10.37349\/ent.2022.00028","volume":"2","author":"FJC Souza-Junior","year":"2022","unstructured":"Souza-Junior FJC, Cunha LC, Lisboa SF (2022) Toll-like receptor 4 in the interface between neuroimmune response and behavioral alterations caused by stress. Explor Neuroprotect Ther 2:182\u2013209","journal-title":"Explor Neuroprotect Ther"},{"key":"2123_CR51","doi-asserted-by":"publisher","first-page":"3427","DOI":"10.3390\/jcm14103427","volume":"14","author":"A Stieger","year":"2025","unstructured":"Stieger A, Asadauskas A, Luedi MM, Andereggen L (2025) Women\u2019s pain management across the lifespan\u2014a narrative review of hormonal, physiological, and psychosocial perspectives. J Clin Med 14:3427","journal-title":"J Clin Med"},{"key":"2123_CR52","doi-asserted-by":"publisher","DOI":"10.3390\/nu13051634","volume":"13","author":"MS Toporovski","year":"2021","unstructured":"Toporovski MS, de Morais MB, Abuhab A, Crippa J\u00fanior MA (2021) Effect of polydextrose\/fructooligosaccharide mixture on constipation symptoms in children aged 4 to 8 years. Nutrients 13:1634","journal-title":"Nutrients"},{"key":"2123_CR53","doi-asserted-by":"publisher","first-page":"131","DOI":"10.2147\/JPR.S234334","volume":"13","author":"C Tu","year":"2020","unstructured":"Tu C, Wu D-Z, Huang Y-S, Zhuang J-S, Zeng J-H, Xu P, Meng T-T, Zhong Z-M (2020) Oxidative stress contributes to hyperalgesia in osteoporotic mice. J Pain Res 13:131\u2013142","journal-title":"J Pain Res"},{"key":"2123_CR54","unstructured":"Valdes A, Patel P, Bajaj T (2025) Estrogen therapy. StatPearls. StatPearls Publishing"},{"key":"2123_CR55","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1210\/er.2014-1100","volume":"36","author":"LA Velloso","year":"2015","unstructured":"Velloso LA, Folli F, Saad MJ (2015) TLR4 at the crossroads of nutrients, gut microbiota, and metabolic inflammation. Endocr Rev 36:245\u2013271","journal-title":"Endocr Rev"},{"key":"2123_CR56","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2022.951186","volume":"13","author":"P Vigil","year":"2022","unstructured":"Vigil P, Melendez J, Petkovic G, del R\u00edo JP (2022) The importance of estradiol for body weight regulation in women. Front Endocrinol 13:951186","journal-title":"Front Endocrinol"},{"key":"2123_CR57","unstructured":"Vlas A, Bhandari S (2025) Improving cognitive functions with prebiotics and probiotics and discussing their relation to gut health: a nursing perspective"},{"key":"2123_CR58","doi-asserted-by":"publisher","first-page":"724","DOI":"10.3389\/fimmu.2020.00724","volume":"11","author":"J Yang","year":"2020","unstructured":"Yang J, Wise L, Fukuchi K-I (2020) TLR4 cross-talk with NLRP3 inflammasome and complement signaling pathways in Alzheimer\u2019s disease. Front Immunol 11:724","journal-title":"Front Immunol"},{"key":"2123_CR59","doi-asserted-by":"publisher","first-page":"4834","DOI":"10.3390\/ijms25094834","volume":"25","author":"S Yoo","year":"2024","unstructured":"Yoo S, Jung S-C, Kwak K, Kim J-S (2024) The role of prebiotics in modulating gut microbiota: implications for human health. Int J Mol Sci 25:4834","journal-title":"Int J Mol Sci"},{"key":"2123_CR60","doi-asserted-by":"publisher","DOI":"10.21037\/atm-20-5842","volume":"8","author":"Y Zhang","year":"2020","unstructured":"Zhang Y, Zhao Q (2020) AEG-1 deletion promotes cartilage repair and modulates bone remodeling-related cytokines via TLR4\/MyD88\/NF-\u03baB inhibition in ovariectomized rats with osteoporosis. Ann Transl Med 8:1298","journal-title":"Ann Transl Med"},{"key":"2123_CR61","doi-asserted-by":"publisher","first-page":"3993","DOI":"10.3390\/foods13243993","volume":"13","author":"H Zhen","year":"2024","unstructured":"Zhen H, Qian H, Liu X, Tan C (2024) Fructooligosaccharides for relieving functional constipation: a systematic review and meta-analysis of randomized controlled trials. Foods 13:3993","journal-title":"Foods"},{"issue":"3","key":"2123_CR62","volume":"17","author":"A Zim","year":"2025","unstructured":"Zim A, Bommareddy A, Zim AN (2025) Estrogen\u2013gut\u2013brain axis: Examining the role of combined oral contraceptives on mental health through their impact on the gut microbiome. Cureus 17(3):e81354","journal-title":"Cureus"}],"container-title":["Inflammopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10787-026-02123-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10787-026-02123-7","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10787-026-02123-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T20:02:48Z","timestamp":1773777768000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10787-026-02123-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,14]]},"references-count":62,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,3]]}},"alternative-id":["2123"],"URL":"https:\/\/doi.org\/10.1007\/s10787-026-02123-7","relation":{},"ISSN":["0925-4692","1568-5608"],"issn-type":[{"value":"0925-4692","type":"print"},{"value":"1568-5608","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2,14]]},"assertion":[{"value":"16 July 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 January 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 February 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare that they have no conflict of interests to disclose.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"The study was approved by the Institutional Animal Ethics Committee (IAEC) of M.M. College of Pharmacy, Maharishi Markandeshwar (Deemed to be University), Mullana, Ambala, Haryana-133207 vide protocol number: MMCP-IAEC-152 dated 16.03.2024.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}}]}}