{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T12:02:44Z","timestamp":1777982564486,"version":"3.51.4"},"reference-count":24,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2026,2,23]],"date-time":"2026-02-23T00:00:00Z","timestamp":1771804800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,2,23]],"date-time":"2026-02-23T00:00:00Z","timestamp":1771804800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100004484","name":"Tehran University of Medical Sciences and Health Services","doi-asserted-by":"publisher","award":["1404-1-101-91099"],"award-info":[{"award-number":["1404-1-101-91099"]}],"id":[{"id":"10.13039\/501100004484","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Inflammopharmacol"],"published-print":{"date-parts":[[2026,3]]},"DOI":"10.1007\/s10787-026-02157-x","type":"journal-article","created":{"date-parts":[[2026,2,23]],"date-time":"2026-02-23T08:48:17Z","timestamp":1771836497000},"page":"1959-1972","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["From anthelmintic to neurotherapeutic: exploring the regenerative potential of niclosamide in sciatic nerve injury"],"prefix":"10.1007","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-9924-3541","authenticated-orcid":false,"given":"Ali","family":"Darabniya","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Reza","family":"Fazeli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sara","family":"Shahriari","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seyed Mohammad","family":"Tavangar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ahmad Reza","family":"Dehpour","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2026,2,23]]},"reference":[{"issue":"6","key":"2157_CR1","doi-asserted-by":"publisher","first-page":"886","DOI":"10.4103\/1673-5374.208546","volume":"12","author":"A Angelova","year":"2017","unstructured":"Angelova A, Angelov B (2017) Dual and multi-drug delivery nanoparticles towards neuronal survival and synaptic repair. Neural Regen Res 12(6):886\u2013889. https:\/\/doi.org\/10.4103\/1673-5374.208546","journal-title":"Neural Regen Res"},{"issue":"1","key":"2157_CR2","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1016\/0304-3959(88)90209-6","volume":"33","author":"GJ Bennett","year":"1988","unstructured":"Bennett GJ, Xie YK (1988) A peripheral mononeuropathy in rat that produces disorders of pain sensation like those seen in man. Pain 33(1):87\u2013107. https:\/\/doi.org\/10.1016\/0304-3959(88)90209-6","journal-title":"Pain"},{"issue":"1\u20132","key":"2157_CR3","doi-asserted-by":"publisher","first-page":"277","DOI":"10.1016\/s0091-3057(01)00659-1","volume":"71","author":"JE Blevins","year":"2002","unstructured":"Blevins JE, Stanley BG, Reidelberger RD (2002) DMSO as a vehicle for central injections: tests with feeding elicited by norepinephrine injected into the paraventricular nucleus. Pharmacol Biochem Behav 71(1\u20132):277\u201382. https:\/\/doi.org\/10.1016\/s0091-3057(01)00659-1","journal-title":"Pharmacol Biochem Behav"},{"issue":"5","key":"2157_CR4","doi-asserted-by":"publisher","first-page":"1111","DOI":"10.1097\/ALN.0b013e3181bbcc26","volume":"111","author":"CM Brummett","year":"2009","unstructured":"Brummett CM, Padda AK, Amodeo FS, Welch KB, Lydic R (2009) Perineural dexmedetomidine added to ropivacaine causes a dose-dependent increase in the duration of thermal antinociception in sciatic nerve block in rat. Anesthesiology 111(5):1111\u20139. https:\/\/doi.org\/10.1097\/ALN.0b013e3181bbcc26","journal-title":"Anesthesiology"},{"key":"2157_CR5","doi-asserted-by":"publisher","DOI":"10.1007\/s10787-025-01952-2","author":"A Darabniya","year":"2025","unstructured":"Darabniya A (2025a) The neuroinflammatory triumvirate: NF-\u03baB, NLRP3, and mTOR in spinal cord injury. Inflammopharmacology. https:\/\/doi.org\/10.1007\/s10787-025-01952-2","journal-title":"Inflammopharmacology"},{"key":"2157_CR6","doi-asserted-by":"publisher","DOI":"10.1007\/s10787-025-02009-0","author":"A Darabniya","year":"2025","unstructured":"Darabniya A (2025b) The forgotten inflammasomes: AIM2, NLRP1, and NLRC4 in spinal cord injury and neuroinflammation. Inflammopharmacology. https:\/\/doi.org\/10.1007\/s10787-025-02009-0","journal-title":"Inflammopharmacology"},{"key":"2157_CR7","doi-asserted-by":"publisher","DOI":"10.1007\/s10787-025-01863-2","author":"A Darabniya","year":"2025","unstructured":"Darabniya A, Darabniya M, Rezaei SJ, Davoodi A, Azarmehr E, Shokrpoor S, Falahatipour SK (2025) Macroscopic and microscopic evaluation of the therapeutic effects of fosfomycin on surgical wound healing in a rat model. Inflammopharmacology. https:\/\/doi.org\/10.1007\/s10787-025-01863-2","journal-title":"Inflammopharmacology"},{"key":"2157_CR22","doi-asserted-by":"publisher","unstructured":"Darabniya A, Shahriari S (2025) Fazeli R et al Niclosamide as a neuroprotective and anti-inflammatory agent: a potential therapeutic approach for spinal cord Injury. 03 Oct 2025. PREPRINT (Version 1) available at Research Square [https:\/\/doi.org\/10.21203\/rs.3.rs-7609682\/v1]","DOI":"10.21203\/rs.3.rs-7609682\/v1]"},{"issue":"2","key":"2157_CR8","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1016\/S0304-3959(00)00276-1","volume":"87","author":"I Decosterd","year":"2000","unstructured":"Decosterd I, Woolf CJ (2000) Spared nerve injury: an animal model of persistent peripheral neuropathic pain. Pain 87(2):149\u2013158. https:\/\/doi.org\/10.1016\/S0304-3959(00)00276-1","journal-title":"Pain"},{"issue":"12","key":"2157_CR9","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2024.e33050","volume":"10","author":"Z Ebrahim Soltani","year":"2024","unstructured":"Ebrahim Soltani Z, Elahi M, Askari Rad M, Farsio S, Dehpour AR (2024) Niclosamide: a potential antipruritic agent by modulating serotonin pathway through metabotropic glutamate receptors (mGluRs). Heliyon 10(12):e33050. https:\/\/doi.org\/10.1016\/j.heliyon.2024.e33050","journal-title":"Heliyon"},{"key":"2157_CR23","doi-asserted-by":"crossref","unstructured":"International Association for the Study of Pain. Guidelines for the Use of Animals in Research. Pain (1983) ;16(2):109\u2013110. Available from: https:\/\/www.iasppain.org (https:\/\/www.iasp-pain.org\/)","DOI":"10.1016\/0304-3959(83)90201-4"},{"issue":"2","key":"2157_CR10","doi-asserted-by":"publisher","first-page":"334","DOI":"10.1007\/s00221-006-0499-2","volume":"173","author":"FM Ja\u2019afer","year":"2006","unstructured":"Ja\u2019afer FM, Hamdan FB, Mohammed FH (2006) Vincristine-induced neuropathy in rat: electrophysiological and histological study. Exp Brain Res 173(2):334\u201345. https:\/\/doi.org\/10.1007\/s00221-006-0499-2","journal-title":"Exp Brain Res"},{"issue":"8","key":"2157_CR11","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.25372","volume":"102","author":"B Jing","year":"2024","unstructured":"Jing B, Chen ZN, Si WM, Zhao JJ, Zhao GP, Zhang D (2024) (+)-catechin attenuates CCI-induced neuropathic pain in male rats by promoting the Nrf2 antioxidant pathway to inhibit ROS\/TLR4\/NF-\u03baB-mediated activation of the NLRP3 inflammasome. J Neurosci Res 102(8):e25372. https:\/\/doi.org\/10.1002\/jnr.25372","journal-title":"J Neurosci Res"},{"key":"2157_CR12","doi-asserted-by":"publisher","first-page":"110","DOI":"10.1016\/j.bbi.2022.02.008","volume":"102","author":"A Lama","year":"2022","unstructured":"Lama A, Pirozzi C, Severi I, Morgese MG, Senzacqua M, Annunziata C, Comella F, Del Piano F, Schiavone S, Petrosino S, Mollica MP, Diano S, Trabace L, Calignano A, Giordano A, Mattace Raso G, Meli R (2022) Palmitoylethanolamide dampens neuroinflammation and anxiety-like behavior in obese mice. Brain Behav Immun 102:110\u2013123. https:\/\/doi.org\/10.1016\/j.bbi.2022.02.008","journal-title":"Brain Behav Immun"},{"issue":"4","key":"2157_CR13","doi-asserted-by":"publisher","first-page":"384","DOI":"10.1089\/neu.2007.0396","volume":"25","author":"EM Lang","year":"2008","unstructured":"Lang EM, Schlegel N, Reiners K, Hofmann GO, Sendtner M, Asan E (2008) Single-dose application of CNTF and BDNF improves remyelination of regenerating nerve fibers after C7 ventral root avulsion and replantation. J Neurotrauma 25(4):384\u2013400. https:\/\/doi.org\/10.1089\/neu.2007.0396","journal-title":"J Neurotrauma"},{"issue":"12","key":"2157_CR14","doi-asserted-by":"publisher","DOI":"10.1111\/cns.70138","volume":"30","author":"M Lei","year":"2024","unstructured":"Lei M, Liu Q, Nie J, Huang R, Mei Y, Pan D, Chen Y, Liu W (2024) Impact and mechanisms of action of BDNF on neurological disorders, cancer, and cardiovascular diseases. CNS Neurosci Ther 30(12):e70138. https:\/\/doi.org\/10.1111\/cns.70138","journal-title":"CNS Neurosci Ther"},{"issue":"2","key":"2157_CR15","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23020918","volume":"23","author":"B Lopes","year":"2022","unstructured":"Lopes B, Sousa P, Alvites R, Branquinho M, Sousa AC, Mendon\u00e7a C, Atayde LM, Lu\u00eds AL, Varej\u00e3o ASP, Maur\u00edcio AC (2022) Peripheral nerve injury treatments and advances: one health perspective. Int J Mol Sci 23(2):918. https:\/\/doi.org\/10.3390\/ijms23020918","journal-title":"Int J Mol Sci"},{"issue":"3","key":"2157_CR16","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines13030589","volume":"13","author":"Z Nashtahosseini","year":"2025","unstructured":"Nashtahosseini Z, Eslami M, Paraandavaji E, Haraj A, Dowlat BF, Hosseinzadeh E, Oksenych V, Naderian R (2025) Cytokine signaling in diabetic neuropathy: a key player in peripheral nerve damage. Biomedicines 13(3):589. https:\/\/doi.org\/10.3390\/biomedicines13030589","journal-title":"Biomedicines"},{"issue":"6","key":"2157_CR17","doi-asserted-by":"publisher","first-page":"1186","DOI":"10.1097\/00000542-199212000-00021","volume":"77","author":"JP Penning","year":"1992","unstructured":"Penning JP, Yaksh TL (1992) Interaction of intrathecal morphine with bupivacaine and lidocaine in the rat. Anesthesiology 77(6):1186\u20132000. https:\/\/doi.org\/10.1097\/00000542-199212000-00021","journal-title":"Anesthesiology"},{"issue":"10","key":"2157_CR18","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21103509","volume":"21","author":"AF Peritore","year":"2020","unstructured":"Peritore AF, Siracusa R, Fusco R, Gugliandolo E, D\u2019Amico R, Cordaro M, Crupi R, Genovese T, Impellizzeri D, Cuzzocrea S, Di Paola R (2020) Ultramicronized palmitoylethanolamide and paracetamol, a new association to relieve hyperalgesia and pain in a sciatic nerve injury model in rat. Int J Mol Sci 21(10):3509. https:\/\/doi.org\/10.3390\/ijms21103509","journal-title":"Int J Mol Sci"},{"issue":"47","key":"2157_CR19","doi-asserted-by":"publisher","first-page":"14932","DOI":"10.1523\/JNEUROSCI.2769-09.2009","volume":"29","author":"M Sasaki","year":"2009","unstructured":"Sasaki M, Radtke C, Tan AM, Zhao P, Hamada H, Houkin K, Honmou O, Kocsis JD (2009) BDNF-hypersecreting human mesenchymal stem cells promote functional recovery, axonal sprouting, and protection of corticospinal neurons after spinal cord injury. J Neurosci 29(47):14932\u201341. https:\/\/doi.org\/10.1523\/JNEUROSCI.2769-09.2009","journal-title":"J Neurosci"},{"key":"2157_CR20","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2025.115402","volume":"164","author":"D Shen","year":"2025","unstructured":"Shen D, Fan S, Kong W, Yuan H, Wei X, Zheng K, Cao S, Huang L, Chu L, Ge L (2025) Research progress on the interaction of artemisinin and its derivatives with TLR4 receptors in neuroinflammation. Int Immunopharmacol 164:115402. https:\/\/doi.org\/10.1016\/j.intimp.2025.115402","journal-title":"Int Immunopharmacol"},{"issue":"10","key":"2157_CR21","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbc.2025.110654","volume":"301","author":"LQ Ye","year":"2025","unstructured":"Ye LQ, Huang XX, Liu HF, Li T, Wang Y, Chen XH, Zheng Y, Chen ZM, Liu QY, Yang F, Li NQ, Wan L (2025) The cation channel Trpa1 and chemokine Cxcl1 mediate axonal degeneration in spared nerve injury-induced neuropathic pain. J Biol Chem 301(10):110654. https:\/\/doi.org\/10.1016\/j.jbc.2025.110654","journal-title":"J Biol Chem"},{"issue":"20","key":"2157_CR24","doi-asserted-by":"publisher","first-page":"2191","DOI":"10.1001\/jama.2013.281053","volume":"310","author":"World Medical Association","year":"2013","unstructured":"World Medical Association (2013) World Medical Association declaration of Helsinki: ethical principles for medical research involving human subjects. JAMA 310(20):2191\u20132194","journal-title":"JAMA"}],"container-title":["Inflammopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10787-026-02157-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10787-026-02157-x","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10787-026-02157-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T20:03:42Z","timestamp":1773777822000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10787-026-02157-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,23]]},"references-count":24,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,3]]}},"alternative-id":["2157"],"URL":"https:\/\/doi.org\/10.1007\/s10787-026-02157-x","relation":{"has-preprint":[{"id-type":"doi","id":"10.21203\/rs.3.rs-7922458\/v1","asserted-by":"object"}]},"ISSN":["0925-4692","1568-5608"],"issn-type":[{"value":"0925-4692","type":"print"},{"value":"1568-5608","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2,23]]},"assertion":[{"value":"22 October 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 February 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 February 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"Not applicable. No human participants were involved in this study.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}}]}}