{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T09:45:17Z","timestamp":1784627117967,"version":"3.55.0"},"reference-count":83,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2026,2,28]],"date-time":"2026-02-28T00:00:00Z","timestamp":1772236800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,2,28]],"date-time":"2026-02-28T00:00:00Z","timestamp":1772236800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100007298","name":"Urmia University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007298","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Inflammopharmacol"],"published-print":{"date-parts":[[2026,4]]},"DOI":"10.1007\/s10787-026-02165-x","type":"journal-article","created":{"date-parts":[[2026,2,28]],"date-time":"2026-02-28T06:21:45Z","timestamp":1772259705000},"page":"2511-2526","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Therapeutic potential of fucoidan from a persian gulf alga (Sargassum tenerrimum) in rheumatoid arthritis: In vivo evaluation in a rat model"],"prefix":"10.1007","volume":"34","author":[{"given":"Leila","family":"Mahmoudzadeh","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seyyed Meysam","family":"Abtahi Froushani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seyede Soraya","family":"Mahmoudi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,2,28]]},"reference":[{"key":"2165_CR1","first-page":"632","volume":"17","author":"SM Abtahi Froushani","year":"2014","unstructured":"Abtahi Froushani SM, Esmaili Gourvarchin Galeh H (2014) New insight into the immunomodulatory mechanisms of Tretinoin in NMRI mice. Iran J Basic Med Sci 17:632\u2013637","journal-title":"Iran J Basic Med Sci"},{"key":"2165_CR2","doi-asserted-by":"publisher","first-page":"33","DOI":"10.5812\/zjrms.83762","volume":"21","author":"SM Abtahi Froushani","year":"2019","unstructured":"Abtahi Froushani SM, Mashhouri S (2019) The effect of mesenchymal stem cells pulsed with 17 beta-estradiol in an ameliorating rat model of ulcerative colitis. Zahedan J Res Med Sci 21:33\u201345","journal-title":"Zahedan J Res Med Sci"},{"key":"2165_CR3","doi-asserted-by":"publisher","first-page":"8131","DOI":"10.1039\/C3RA23373A","volume":"3","author":"MT Alea","year":"2013","unstructured":"Alea MT, Meyer AS (2013) Fucoidans from brown seaweeds: an update on structures, extraction techniques and use of enzymes as tools for structural elucidation. RSC Adv 3:8131\u20138141","journal-title":"RSC Adv"},{"key":"2165_CR4","doi-asserted-by":"publisher","first-page":"626","DOI":"10.1016\/j.jaci.2014.11.001","volume":"135","author":"F Annunziato","year":"2015","unstructured":"Annunziato F, Romagnani C, Romagnani S (2015) The 3 major types of innate and adaptive cell-mediated effector immunity. J Allergy Clin Immunol 135:626\u2013635","journal-title":"J Allergy Clin Immunol"},{"key":"2165_CR5","doi-asserted-by":"publisher","DOI":"10.3390\/polym12102338","volume":"12","author":"E Apostolova","year":"2020","unstructured":"Apostolova E, Lukova P, Baldzhieva A, Katsarov P, Nikolova M, Iliev L, Peychev L, Trica B, Oancea F, Delattre C, Kokova V (2020a) Immunomodulatory and anti-inflammatory effects of Fucoidan: a review. Polymers (Basel) 12:2338","journal-title":"Polymers (Basel)"},{"key":"2165_CR6","doi-asserted-by":"publisher","DOI":"10.3390\/polym12102338","volume":"12","author":"E Apostolova","year":"2020","unstructured":"Apostolova E, Lukova P, Baldzhieva A, Katsarov P, Nikolova M, Iliev I, Peychev L, Trica B, Oancea F, Delattre C, Kokova V (2020b) Immunomodulatory and anti-inflammatory effects of Fucoidan: a review. Polymers 12:2338","journal-title":"Polymers"},{"key":"2165_CR7","doi-asserted-by":"publisher","first-page":"1259","DOI":"10.1016\/j.ijbiomac.2019.10.172","volume":"151","author":"O Ashayerizadeh","year":"2020","unstructured":"Ashayerizadeh O, Dastar B, Pourashouri P (2020) Study of antioxidant and antibacterial activities of depolymerized fucoidans extracted from Sargassum tenerrimum. Int J Biol Macromol 151:1259\u20131266","journal-title":"Int J Biol Macromol"},{"issue":"1","key":"2165_CR8","first-page":"114","volume":"18","author":"R Baharlou","year":"2019","unstructured":"Baharlou R, Rashidi N, Vasmehjani AA, Khoubyari M, Sheikh M, Erfanian S (2019) Immunomodulatory effects of human adipose tissue-derived mesenchymal stem cells on T cell subsets in patients with rheumatoid arthritis. Iran J Allergy Asthma Immunol 18(1):114\u2013119","journal-title":"Iran J Allergy Asthma Immunol"},{"key":"2165_CR9","doi-asserted-by":"publisher","DOI":"10.3390\/molecules27041326","volume":"27","author":"S Baliyan","year":"2022","unstructured":"Baliyan S, Mukherjee R, Priyadarshini A, Vibhuti A, Gupta A, Pandey RP, Chang CM (2022) Determination of antioxidants by DPPH radical scavenging activity and quantitative phytochemical analysis of Ficus religiosa. Molecules 27:1326","journal-title":"Molecules"},{"key":"2165_CR10","first-page":"439","volume":"29","author":"SS Bassuk","year":"2004","unstructured":"Bassuk SS, Rifai N, Ridker PM (2004) High-sensitivity C-reactive protein: clinical importance. Curr Probl Cardiol 29:439\u2013493","journal-title":"Curr Probl Cardiol"},{"key":"2165_CR11","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2020.114147","volume":"180","author":"S Bindu","year":"2020","unstructured":"Bindu S, Mazumder S, Bandyopadhyay U (2020) Non-steroidal anti-inflammatory drugs (NSAIDs) and organ damage: a current perspective. Biochem Pharmacol 180:114147","journal-title":"Biochem Pharmacol"},{"key":"2165_CR13","first-page":"171","volume":"68","author":"S Chadha","year":"2020","unstructured":"Chadha S, Behl T, Kumar A, Khullar G, Arora S (2020) Role of Nrf2 in rheumatoid arthritis. Curr Res Transl Med 68:171\u2013181","journal-title":"Curr Res Transl Med"},{"key":"2165_CR15","doi-asserted-by":"publisher","DOI":"10.1177\/1759720X221137127","volume":"14","author":"EI Ciofoaia","year":"2022","unstructured":"Ciofoaia EI, Pillarisetty A, Constantinescu F (2022) Health disparities in rheumatoid arthritis. Ther Adv Musculoskelet Dis 14:1759720x221137127","journal-title":"Ther Adv Musculoskelet Dis"},{"key":"2165_CR16","doi-asserted-by":"publisher","first-page":"422","DOI":"10.1111\/j.1440-1681.2009.05314.x","volume":"37","author":"YQ Cui","year":"2010","unstructured":"Cui YQ, Zhang LJ, Zhang T, Luo DZ, Jia YJ, Guo ZX, Zhang QB, Wang X, Wang XM (2010) Inhibitory effect of fucoidan on nitric oxide production in lipopolysaccharide-activated primary microglia. Clin Exp Pharmacol Physiol 37:422\u2013428","journal-title":"Clin Exp Pharmacol Physiol"},{"issue":"3","key":"2165_CR17","doi-asserted-by":"publisher","first-page":"277","DOI":"10.1084\/jem.20040165","volume":"200","author":"MR Ehrenstein","year":"2004","unstructured":"Ehrenstein MR, Evans JG, Singh A, Moore S, Warnes G, Isenberg DA, Mauri C (2004) Compromised function of regulatory T cells in rheumatoid arthritis and reversal by anti-TNFalpha therapy. J Exp Med 200(3):277\u2013285","journal-title":"J Exp Med"},{"key":"2165_CR18","doi-asserted-by":"publisher","first-page":"457","DOI":"10.3390\/md22100457","volume":"22","author":"S Ersoydan","year":"2024","unstructured":"Ersoydan S, Rustemeyer T (2024) Investigating the anti-inflammatory activity of various brown algae species. Mar Drugs 22:457","journal-title":"Mar Drugs"},{"key":"2165_CR19","doi-asserted-by":"publisher","first-page":"935","DOI":"10.1007\/s10787-022-00957-5","volume":"30","author":"S Etemadi","year":"2022","unstructured":"Etemadi S, Abtahi Froushani SM, Hashemi Asl SM, Mahmoudian A (2022) Combined atorvastatin and pentoxifylline in ameliorating inflammation induced by complete Freund\u2019s adjuvant. Inflammopharmacology 30:935\u2013944","journal-title":"Inflammopharmacology"},{"key":"2165_CR20","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2020.117420","volume":"246","author":"EM Ghaffary","year":"2020","unstructured":"Ghaffary EM, Abtahi Froushani SM (2020) Immunomodulatory benefits of mesenchymal stem cells treated with Caffeine in adjuvant-induced arthritis. Life Sci 246:117420","journal-title":"Life Sci"},{"key":"2165_CR21","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2019.117037","volume":"239","author":"S Golbahari","year":"2019","unstructured":"Golbahari S, Abtahi Froushani SM (2019) Synergistic benefits of Nicotine and Thymol in alleviating experimental rheumatoid arthritis. Life Sci 239:117037","journal-title":"Life Sci"},{"key":"2165_CR22","doi-asserted-by":"publisher","DOI":"10.1016\/j.eti.2024.103980","volume":"37","author":"S Gurau","year":"2025","unstructured":"Gurau S, Imran M, Ray RL (2025) Algae: a cutting-edge solution for enhancing soil health and accelerating carbon sequestration \u2013 a review. Environmental Technology & Innovation 37:103980","journal-title":"Environmental Technology & Innovation"},{"key":"2165_CR23","first-page":"903","volume":"76","author":"A Hajizadeh","year":"2021","unstructured":"Hajizadeh A, Abtahi Froushani SM, Tehrani AA, Azizi S, Hashemi SRB (2021) Effects of naringenin on experimentally induced rheumatoid arthritis in Wistar rats. Arch Razi Inst 76:903\u2013912","journal-title":"Arch Razi Inst"},{"key":"2165_CR25","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1016\/j.foodhyd.2015.09.022","volume":"54","author":"AF Hifney","year":"2016","unstructured":"Hifney AF, Fawzy MA, Abdel-Gawad KM, Gomaa M (2016) Industrial optimization of fucoidan extraction from Sargassum sp. and its potential antioxidant and emulsifying activities. Food Hydrocolloids 54:77\u201388","journal-title":"Food Hydrocolloids"},{"key":"2165_CR26","doi-asserted-by":"publisher","first-page":"14","DOI":"10.5530\/pj.2017.1.3","volume":"9","author":"A Isnansetyo","year":"2017","unstructured":"Isnansetyo A, Lutfia FNL, Nursid M, Trijoko, Susidarti RA (2017) Cytotoxicity of Fucoidan from Three Tropical Brown Algae Against Breast and Colon Cancer Cell Lines. Pharmacognosy J 9:14\u201320","journal-title":"Pharmacognosy J"},{"key":"2165_CR27","doi-asserted-by":"publisher","first-page":"1527","DOI":"10.3390\/antiox13121527","volume":"13","author":"Y Izumi","year":"2024","unstructured":"Izumi Y, Koyama Y (2024) Nrf2-independent anti-inflammatory effects of dimethyl fumarate: challenges and prospects in developing electrophilic Nrf2 activators for neurodegenerative diseases. Antioxid (Basel) 13:1527","journal-title":"Antioxid (Basel)"},{"key":"2165_CR28","first-page":"381","volume":"14","author":"YS Jafari- Khataylou, Kazemi-Darabadi","year":"2023","unstructured":"Jafari- Khataylou, Kazemi-Darabadi YS, Ahmadi Afshar S (2023) Effects of adenosine N1-Oxide and pioglitazone on inflammatory and antioxidant state in sepsis caused by experimental cecal puncture in rat. Veterinary Res Forum 14:381\u2013387","journal-title":"Veterinary Res Forum"},{"key":"2165_CR29","first-page":"400","volume":"26","author":"M Jahantigh","year":"2023","unstructured":"Jahantigh M, Abtahi Froushani SM, Afzale Ahangaran N (2023) Benefits of bone marrow-derived mesenchymal stem cells primed with estradiol in alleviating collagen-induced arthritis. Iran J Basic Med Sci 26:400\u2013407","journal-title":"Iran J Basic Med Sci"},{"key":"2165_CR30","doi-asserted-by":"publisher","DOI":"10.3390\/ph17030283","volume":"17","author":"T Jamtsho","year":"2024","unstructured":"Jamtsho T, Yeshi K, Perry MJ, Loukas A, Wangchuk P (2024) Approaches, strategies and procedures for identifying anti-inflammatory drug lead molecules from natural products. Pharmaceuticals (Basel) 17:283","journal-title":"Pharmaceuticals (Basel)"},{"key":"2165_CR31","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1111\/ijfs.12692","volume":"50","author":"SU Kadam","year":"2014","unstructured":"Kadam SU, Tiwari BK, O\u2019Donnell CP (2014) Extraction, structure and biofunctional activities of laminarin from brown algae. Int J Food Sci Technol 50:24\u201331","journal-title":"Int J Food Sci Technol"},{"key":"2165_CR32","doi-asserted-by":"publisher","first-page":"112","DOI":"10.1369\/0022155415610792","volume":"64","author":"J Kajimura","year":"2016","unstructured":"Kajimura J, Ito R, Manley NR, Hale LP (2016) Optimization of single- and dual-color immunofluorescence protocols for formalin-fixed, paraffin-embedded archival tissues. J Histochem Cytochem 64:112\u2013124","journal-title":"J Histochem Cytochem"},{"key":"2165_CR33","doi-asserted-by":"publisher","DOI":"10.1016\/j.eng.2025.06.036","author":"N Kang","year":"2025","unstructured":"Kang N, Zhao J, Gao P, Lu Y, Chen Z, Li X, Khan IA, Yang S, Xu Q, Liu Y (2025) Innovative strategies in natural product drug discovery: the case of Anemoside B4. Engineering. https:\/\/doi.org\/10.1016\/j.eng.2025.06.036","journal-title":"Engineering"},{"key":"2165_CR34","doi-asserted-by":"publisher","first-page":"140","DOI":"10.1126\/scitranslmed.3005580","volume":"5","author":"R Khandpur","year":"2013","unstructured":"Khandpur R, Carmona-Rivera C, Vivekanandan-Giri A, Gizinski A, Yalavarthi S, Knight JS, Friday S, Li S, Patel RM, Subramanian V, Thompson P, Chen P, Fox DA, Pennathur S, Kaplan MJ (2013) NETs are a source of citrullinated autoantigens and stimulate inflammatory responses in rheumatoid arthritis. Sci Transl Med 5:140\u2013178","journal-title":"Sci Transl Med"},{"key":"2165_CR35","doi-asserted-by":"publisher","first-page":"399","DOI":"10.1002\/ptr.2959","volume":"24","author":"H Kim","year":"2010","unstructured":"Kim H, Moon C, Park EJ, Jee Y, Ahn M, Wie MB, Shin T (2010) Amelioration of experimental autoimmune encephalomyelitis in Lewis rats treated with fucoidan. Phytother Res 24:399\u2013403","journal-title":"Phytother Res"},{"key":"2165_CR36","doi-asserted-by":"publisher","first-page":"e6","DOI":"10.4110\/in.2024.24.e6","volume":"24","author":"HY Kim","year":"2024","unstructured":"Kim HY, Jeong D, Kim JH, Chung DH (2024) Innate type-2 cytokines: from immune regulation to therapeutic targets. Immune Netw 24:e6","journal-title":"Immune Netw"},{"key":"2165_CR37","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2023.1121655","volume":"14","author":"H Kou","year":"2023","unstructured":"Kou H, Huang L, Jin M, He Q, Zhang R, Ma J (2023) Effect of curcumin on rheumatoid arthritis: a systematic review and meta-analysis. Front Immunol 14:1121655","journal-title":"Front Immunol"},{"issue":"24","key":"2165_CR38","doi-asserted-by":"publisher","DOI":"10.3390\/app122413010","volume":"12","author":"A Lakshmanan","year":"2022","unstructured":"Lakshmanan A, Balasubramanian B, Maluventhen V, Malaisamy A, Baskaran R, Liu W-C, Arumugam M (2022) Extraction and characterization of fucoidan derived from Sargassum ilicifolium and its biomedical potential with in silico molecular docking. Appl Sci 12(24):13010","journal-title":"Appl Sci"},{"key":"2165_CR39","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2019.104497","volume":"150","author":"ST Law","year":"2019","unstructured":"Law ST, Taylor PC (2019) Role of biological agents in treatment of rheumatoid arthritis. Pharmacol Res 150:104497","journal-title":"Pharmacol Res"},{"key":"2165_CR40","doi-asserted-by":"publisher","DOI":"10.3389\/fnut.2023.1162934","volume":"10","author":"S Lee","year":"2023","unstructured":"Lee S, Lee EJ, Lee GM, Yun JH, Yoo W (2023) Inhibitory effect of fucoidan on TNF-\u03b1-induced inflammation in human retinal pigment epithelium cells. Front Nutr 10:1162934","journal-title":"Front Nutr"},{"key":"2165_CR41","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1016\/j.foodchem.2016.04.058","volume":"209","author":"SJ Lim","year":"2016","unstructured":"Lim SJ, Aida WMW, Maskat MY, Latip J, Badri KH, Hassan O, Yamin BM (2016) Characterisation of fucoidan extracted from Malaysian Sargassum binderi. Food Chem 209:267\u2013273","journal-title":"Food Chem"},{"key":"2165_CR42","doi-asserted-by":"publisher","first-page":"7","DOI":"10.7150\/ijms.8352","volume":"12","author":"ZW Lin","year":"2015","unstructured":"Lin ZW, Wu LX, Xie Y, Ou X, Tian PK, Liu XP, Min J, Wang J, Chen RF, Chen YJ, Liu C, Ye H, Ou QJ (2015) The expression levels of transcription factors T-bet, GATA-3, ROR\u03b3t and FOXP3 in peripheral blood lymphocyte (PBL) of patients with liver cancer and their significance. Int J Med Sci 12:7\u201316","journal-title":"Int J Med Sci"},{"key":"2165_CR43","doi-asserted-by":"publisher","DOI":"10.3390\/md21030136","volume":"21","author":"A Linares-Maurizi","year":"2023","unstructured":"Linares-Maurizi A, Reversat G, Awad R, Bultel-Ponc\u00e9 V, Oger C, Galano JM, Balas L, Durbec A, Bertrand-Michel J, Durand T, Pradelles R, Vigor C (2023) Bioactive oxylipins profile in marine microalgae. Mar Drugs 21:136","journal-title":"Mar Drugs"},{"key":"2165_CR44","doi-asserted-by":"publisher","DOI":"10.3390\/md17060345","volume":"17","author":"SH Lu","year":"2019","unstructured":"Lu SH, Hsia YJ, Shih KC, Chou TC (2019) Fucoidan prevents RANKL-stimulated osteoclastogenesis and LPS-induced inflammatory bone loss via regulation of Akt\/GSK3\u03b2\/PTEN\/NFATc1 signaling pathway and calcineurin activity. Mar Drugs 17:345","journal-title":"Mar Drugs"},{"key":"2165_CR45","doi-asserted-by":"publisher","first-page":"200","DOI":"10.1186\/ar300","volume":"3","author":"SS Makarov","year":"2001","unstructured":"Makarov SS (2001) NF-kappa B in rheumatoid arthritis: a pivotal regulator of inflammation, hyperplasia, and tissue destruction. Arthritis Res 3:200\u2013206","journal-title":"Arthritis Res"},{"key":"2165_CR46","doi-asserted-by":"publisher","first-page":"402","DOI":"10.3923\/pjbs.2014.402.407","volume":"17","author":"T Marudhupandi","year":"2014","unstructured":"Marudhupandi T, Kumar TT, Senthil SL, Devi KN (2014a) In vitro antioxidant properties of fucoidan fractions from Sargassum tenerrimum. Pak J Biol Sci 17:402\u2013407","journal-title":"Pak J Biol Sci"},{"key":"2165_CR47","doi-asserted-by":"publisher","first-page":"402","DOI":"10.3923\/pjbs.2014.402.407","volume":"17","author":"T Marudhupandi","year":"2014","unstructured":"Marudhupandi T, Kumar TTA, Senthil SL, Devi KN (2014b) In vitro antioxidant properties of fucoidan fractions from Sargassum tenerrimum. Pak J Biol Sci 17:402\u2013407","journal-title":"Pak J Biol Sci"},{"key":"2165_CR48","doi-asserted-by":"publisher","first-page":"549","DOI":"10.3390\/cells9030549","volume":"9","author":"M Massalska","year":"2020","unstructured":"Massalska M, Radzikowska A, Kuca-Warnawin E, Plebanczyk M, Prochorec-Sobieszek M, Skalska U, Kurowska W, Maldyk P, Kontny E, Gober HJ, Maslinski W (2020) CD4\u2009+\u2009FOXP3+ T cells in rheumatoid arthritis bone marrow are partially impaired. Cells 9:549","journal-title":"Cells"},{"key":"2165_CR49","doi-asserted-by":"publisher","first-page":"104","DOI":"10.2174\/0118715230264101230925060355","volume":"22","author":"S Mirzaaghasi","year":"2023","unstructured":"Mirzaaghasi S, Abtahi Froushani SM (2023) Immunomodulatory effects of combined nicotinic acid and prednisolone in adjuvant-induced arthritis. Antiinflamm Antiallergy Agents Med Chem 22:104\u2013112","journal-title":"Antiinflamm Antiallergy Agents Med Chem"},{"key":"2165_CR50","doi-asserted-by":"publisher","first-page":"1126","DOI":"10.1089\/ars.2012.5149","volume":"20","author":"M Mittal","year":"2014","unstructured":"Mittal M, Siddiqui MR, Tran K, Reddy SP, Malik AB (2014) Reactive oxygen species in inflammation and tissue injury. Antioxid Redox Signal 20:1126\u20131167","journal-title":"Antioxid Redox Signal"},{"key":"2165_CR51","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2020.117420","volume":"246","author":"E Moases Ghaffary","year":"2020","unstructured":"Moases Ghaffary E, Abtahi Froushani SM (2020) Immunomodulatory benefits of mesenchymal stem cells treated with Caffeine in adjuvant-induced arthritis. Life Sci 246:117420","journal-title":"Life Sci"},{"key":"2165_CR52","first-page":"117","volume":"16","author":"A Morvaridi","year":"2025","unstructured":"Morvaridi A, Abtahi Froushani SM, Farshid AA (2025) Benefits of combining piperine with prednisolone in an experimental model of rheumatoid arthritis. Vet Res Forum 16:117\u2013124","journal-title":"Vet Res Forum"},{"issue":"7","key":"2165_CR53","doi-asserted-by":"publisher","first-page":"2453","DOI":"10.1007\/s13197-020-04837-0","volume":"58","author":"J Muthukumar","year":"2021","unstructured":"Muthukumar J, Chidambaram R, Sukumaran S (2021) Sulfated polysaccharides and its commercial applications in food industries-a review. J Food Sci Technol 58(7):2453\u20132466","journal-title":"J Food Sci Technol"},{"key":"2165_CR54","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1016\/j.bj.2020.10.001","volume":"44","author":"T Nabekura","year":"2021","unstructured":"Nabekura T, Shibuya A (2021) Type 1 innate lymphoid cells: soldiers at the front line of immunity. Biomed J 44:115\u2013122","journal-title":"Biomed J"},{"issue":"10","key":"2165_CR55","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2024.103636","volume":"23","author":"J Narv\u00e1ez","year":"2024","unstructured":"Narv\u00e1ez J, Aguilar-Coll M, Roig-Kim M, Maym\u00f3-Paituvi P, Palacios-Olid J, Nolla JM, LLop D (2024) Janus kinase inhibitors in rheumatoid arthritis-associated interstitial lung disease: a systematic review and meta-analysis. Autoimmun Rev 23(10):103636","journal-title":"Autoimmun Rev"},{"key":"2165_CR56","doi-asserted-by":"publisher","first-page":"2345","DOI":"10.3390\/antiox11122345","volume":"11","author":"V Ngo","year":"2022","unstructured":"Ngo V, Duennwald ML (2022) Nrf2 and oxidative stress: a general overview of mechanisms and implications in human disease. Antioxid (Basel) 11:2345","journal-title":"Antioxid (Basel)"},{"key":"2165_CR57","doi-asserted-by":"publisher","DOI":"10.3390\/molecules25102361","volume":"25","author":"JY Oh","year":"2020","unstructured":"Oh JY, Kim EA, Kang SI, Yang HW, Ryu B, Wang L, Lee JS, Jeon YJ (2020) Protective effects of fucoidan isolated from Celluclast-assisted extract of Undaria pinnatifida sporophylls against AAPH-induced oxidative stress in vitro and in vivo zebrafish model. Molecules 25:2361","journal-title":"Molecules"},{"key":"2165_CR58","first-page":"1","volume":"3","author":"D Pacheco","year":"2020","unstructured":"Pacheco D, Poza SG, Cotas J, Gon\u00e7alves AMM (2020) Fucoidan - a valuable source from the ocean to pharmaceutical. Front Drug Chem Clin Res 3:1\u20134","journal-title":"Front Drug Chem Clin Res"},{"key":"2165_CR59","doi-asserted-by":"crossref","unstructured":"Pal R, Chaudhary MJ, Tiwari PC, Nath R, Pant KK (2018) Pharmacological and biochemical studies on protective effects of mangiferin and its interaction with nitric oxide (NO) modulators in adjuvant-induced changes in arthritic parameters, inflammatory, and oxidative biomarkers in rats. Inflammopharmacology","DOI":"10.1007\/s10787-018-0507-8"},{"key":"2165_CR60","doi-asserted-by":"publisher","first-page":"405","DOI":"10.1016\/j.ijbiomac.2017.03.182","volume":"102","author":"S Palanisamy","year":"2017","unstructured":"Palanisamy S, Vinosha M, Marudhupandi T, Rajasekar P, Prabhu NM (2017) Isolation of fucoidan from Sargassum polycystum brown algae: structural characterization, in vitro antioxidant and anticancer activity. Int J Biol Macromol 102:405\u2013412","journal-title":"Int J Biol Macromol"},{"key":"2165_CR61","doi-asserted-by":"publisher","first-page":"1384","DOI":"10.1002\/ptr.3140","volume":"24","author":"SB Park","year":"2010","unstructured":"Park SB, Chun KR, Kim JK, Suk K, Jung YM, Lee WH (2010) The differential effect of high and low molecular weight fucoidans on the severity of collagen-induced arthritis in mice. Phytother Res 24:1384\u20131391","journal-title":"Phytother Res"},{"key":"2165_CR62","doi-asserted-by":"publisher","first-page":"1745","DOI":"10.1016\/j.fct.2011.04.020","volume":"49","author":"HY Park","year":"2011","unstructured":"Park HY, Han MH, Park C, Jin CY, Kim GY, Choi IW, Kim ND, Nam TJ, Kwon TK, Choi YH (2011) Anti-inflammatory effects of fucoidan through inhibition of NF-\u03baB, MAPK and Akt activation in lipopolysaccharide-induced BV2 microglia cells. Food Chem Toxicol 49:1745\u20131752","journal-title":"Food Chem Toxicol"},{"issue":"4","key":"2165_CR63","doi-asserted-by":"publisher","first-page":"925","DOI":"10.55563\/clinexprheumatol\/q8xvkl","volume":"39","author":"M Patl\u00e1n","year":"2021","unstructured":"Patl\u00e1n M, P\u00e1ez A, Mass\u00f3 F, Amezcua-Guerra LM (2021) Relative increase of Th17 phenotype in senescent CD4\u2009+\u2009CD28null T cells from peripheral blood of patients with rheumatoid arthritis. Clin Exp Rheumatol 39(4):925\u2013926","journal-title":"Clin Exp Rheumatol"},{"key":"2165_CR64","first-page":"35","volume":"21","author":"J Poursamimi","year":"2022","unstructured":"Poursamimi J, Shariati-Sarabi Z, Tavakkol-Afshari J, Mohammadi M (2022) A significant increase in the gene expression of GATA-3 following the treatment of osteoarthritis patients with crocin. Iran J Allergy Asthma Immunol 21:35\u201343","journal-title":"Iran J Allergy Asthma Immunol"},{"key":"2165_CR65","doi-asserted-by":"publisher","first-page":"8855","DOI":"10.1007\/s11033-023-08780-z","volume":"50","author":"SSM Puhari","year":"2023","unstructured":"Puhari SSM, Yuvaraj S, Vasudevan V, Ramprasath T, Arunkumar K, Amutha C, Selvam GS (2023) Fucoidan from Sargassum wightii reduces oxidative stress through upregulating Nrf2\/HO-1 signaling pathway in alloxan-induced diabetic cardiomyopathy rats. Mol Biol Rep 50:8855\u20138866","journal-title":"Mol Biol Rep"},{"key":"2165_CR66","doi-asserted-by":"crossref","unstructured":"Rahawy AM, Al-Mahmood SS, Basim H, Rahawi AM (2021) Standard techniques for formalin-fixed paraffin-embedded tissue: A Pathologist\u2019s perspective. Iraqi J Veterinary Sci 35","DOI":"10.33899\/ijvs.2021.131918.2023"},{"key":"2165_CR67","doi-asserted-by":"publisher","DOI":"10.1016\/j.crbiot.2024.100220","volume":"7","author":"PP Raj","year":"2024","unstructured":"Raj PP, Gopal RK, Sanniyasi E (2024) Investigating the anti-inflammatory and anti-arthritis effects of fucoidan from a brown seaweed.\". Curr Res Biotechnol 7:100220","journal-title":"Curr Res Biotechnol"},{"key":"2165_CR68","doi-asserted-by":"publisher","first-page":"3255","DOI":"10.3892\/mmr.2016.5623","volume":"14","author":"MJ Ryu","year":"2016","unstructured":"Ryu MJ, Chung HS (2016) Fucoidan reduces oxidative stress by regulating the gene expression of HO\u20131 and SOD\u20131 through the Nrf2\/ERK signaling pathway in HaCaT cells. Mol Med Rep 14:3255\u20133260","journal-title":"Mol Med Rep"},{"issue":"1","key":"2165_CR69","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-021-96699-5","volume":"11","author":"M Shimizu","year":"2021","unstructured":"Shimizu M, Kondo Y, Tanimura R, Furuyama K, Yokosawa M, Asashima H, Tsuboi H, Matsumoto I, Sumida T (2021) T-bet represses collagen-induced arthritis by suppressing Th17 lineage commitment through inhibition of ROR\u03b3t expression and function. Sci Rep 11(1):17357","journal-title":"Sci Rep"},{"key":"2165_CR70","doi-asserted-by":"publisher","first-page":"117","DOI":"10.7872\/crya.v35.iss2.2014.117","volume":"35","author":"T Silberfeld","year":"2014","unstructured":"Silberfeld T, Rousseau F, Reviers B (2014) An updated classification of brown algae (Ochrophyta, Phaeophyceae). Cryptogamie Algol 35:117\u2013156","journal-title":"Cryptogamie Algol"},{"key":"2165_CR71","doi-asserted-by":"publisher","first-page":"679","DOI":"10.1016\/j.rdc.2022.03.005","volume":"48","author":"JA Singh","year":"2022","unstructured":"Singh JA (2022) Treatment guidelines in rheumatoid arthritis. Rheum Dis Clin North Am 48:679\u2013689","journal-title":"Rheum Dis Clin North Am"},{"key":"2165_CR72","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-024-61502-8","volume":"14","author":"I Takahashi","year":"2024","unstructured":"Takahashi I, Takeda K, Toyama T, Matsuzaki T, Kuroki H, Hoso M (2024) Histological and immunohistochemical analyses of articular cartilage during onset and progression of pre- and early-stage osteoarthritis in a rodent model. Sci Rep 14:10568","journal-title":"Sci Rep"},{"key":"2165_CR73","doi-asserted-by":"crossref","unstructured":"Tang S, Wang L, Ren X, Song S, Ai C (2024) Fucoidan Alleviates Colitis and Metabolic Disorder by Protecting the Intestinal Barrier, Suppressing the MAPK\/NF-\u03baB Pathways, and Regulating the Gut Microbiota. Journal of Food Biochemistry 2024:7955190","DOI":"10.1155\/2024\/7955190"},{"key":"2165_CR74","doi-asserted-by":"publisher","DOI":"10.3390\/molecules26071937","volume":"26","author":"MY Tsai","year":"2021","unstructured":"Tsai MY, Yang WC, Lin CF, Wang CM, Liu HY, Lin CS, Lin JW, Lin WL, Lin TC, Fan PS, Hung KH, Lu YW, Chang GR (2021) The ameliorative effects of fucoidan in Thioacetaide-induced liver injury in mice. Molecules 26:1937","journal-title":"Molecules"},{"issue":"4","key":"2165_CR75","doi-asserted-by":"publisher","DOI":"10.3390\/phycology5040080","volume":"5","author":"AA Waoo","year":"2025","unstructured":"Waoo AA, Singh S, Chandra N, Mishra S, Singh MP, Mal J, Jha AK, Joo JC, Pandey A (2025) Comprehensive review on the biomedical applications of marine algal polysaccharides. Phycology 5(4):80","journal-title":"Phycology"},{"key":"2165_CR76","doi-asserted-by":"publisher","first-page":"143","DOI":"10.14336\/AD.2017.0306","volume":"9","author":"S Wongrakpanich","year":"2018","unstructured":"Wongrakpanich S, Wongrakpanich A, Melhado K, Rangaswami J (2018) A comprehensive review of non-steroidal anti-inflammatory drug use in the elderly. Aging Dis 9:143\u2013150","journal-title":"Aging Dis"},{"key":"2165_CR77","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1007\/s12026-021-09173-9","volume":"69","author":"I Wo\u015b","year":"2021","unstructured":"Wo\u015b I, Tabarkiewicz J (2021) Effect of interleukin-6, -17, -21, -22, and \u2013\u200923 and STAT3 on signal transduction pathways and their inhibition in autoimmune arthritis. Immunol Res 69:26\u201342","journal-title":"Immunol Res"},{"key":"2165_CR78","first-page":"4993","volume":"20","author":"J Yang","year":"2019","unstructured":"Yang J, Wang J, Liang X, Zhao H, Lu J, Ma Q, Jing B, Tian F F (2019) IL\u20131\u03b2 increases the expression of inflammatory factors in synovial fluid\u2013derived fibroblast\u2013like synoviocytes via activation of the NF\u2013\u03baB\u2013mediated ERK\u2013STAT1 signaling pathway. Mol Med Rep 20:4993\u20135001","journal-title":"Mol Med Rep"},{"key":"2165_CR79","doi-asserted-by":"publisher","first-page":"407","DOI":"10.3390\/antiox13040407","volume":"13","author":"C Yin","year":"2024","unstructured":"Yin C, Bi Q, Chen W, Wang C, Castiglioni B, Li Y, Sun W, Pi Y, Bontempo V, Li X, Jiang X (2024) Fucoidan supplementation improves antioxidant capacity via regulating the Keap1\/Nrf2 signaling pathway and mitochondrial function in low-weaning weight piglets. Antioxid Basel 13:407","journal-title":"Antioxid Basel"},{"key":"2165_CR80","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-025-94312-7","volume":"15","author":"Q Yue","year":"2025","unstructured":"Yue Q, Liu Y, Li F, Hong T, Guo S, Cai M, Zhao L, Su L, Zhang S, Zhao C, Li K (2025) Antioxidant and anticancer properties of fucoidan isolated from Saccharina japonica brown algae. Sci Rep 15:8962","journal-title":"Sci Rep"},{"issue":"11","key":"2165_CR81","doi-asserted-by":"publisher","first-page":"571","DOI":"10.3390\/md18110571","volume":"18","author":"A Zayed","year":"2020","unstructured":"Zayed A, El-Aasr M, Ibrahim AS, Ulber R (2020) Fucoidan characterization: determination of purity and physicochemical and chemical properties. Mar Drugs 18(11):571","journal-title":"Mar Drugs"},{"key":"2165_CR82","doi-asserted-by":"publisher","first-page":"29","DOI":"10.3390\/md22010029","volume":"22","author":"A Zayed","year":"2023","unstructured":"Zayed A, Al-Saedi DA, Mensah EO, Kanwugu ON, Adadi P, Ulber R (2023) Fucoidan\u2019s molecular targets: a comprehensive review of its unique and multiple targets accounting for promising bioactivities supported by in silico studies. Mar Drugs 22:29\u201339","journal-title":"Mar Drugs"},{"key":"2165_CR83","doi-asserted-by":"publisher","first-page":"551","DOI":"10.5650\/jos.ess21413","volume":"71","author":"Z Zeng","year":"2022","unstructured":"Zeng Z, Yan K, Liu W (2022) Specneuzhenide ameliorate complete Freund adjuvant induced arthritis in rats: involvement of NF-\u03baB and HO-1\/Nrf-2 pathway. J Oleo Sci 71:551\u2013561","journal-title":"J Oleo Sci"},{"key":"2165_CR84","doi-asserted-by":"publisher","DOI":"10.3390\/md22090401","volume":"22","author":"W Zhang","year":"2024","unstructured":"Zhang W, Lee PCW, Jin JO (2024) Anti-inflammatory effect of fucoidan from Costaria costata inhibited lipopolysaccharide-induced inflammation in mice. Mar Drugs 22:401","journal-title":"Mar Drugs"},{"key":"2165_CR85","doi-asserted-by":"publisher","first-page":"90","DOI":"10.1016\/j.ijbiomac.2021.01.083","volume":"173","author":"M Zhao","year":"2021","unstructured":"Zhao M, Garcia-Vaquero M, Przyborska J, Sivagnanam SP, Tiwari B (2021) The development of analytical methods for the purity determination of fucoidan extracted from brown seaweed species. Int J Biol Macromol 173:90\u201398","journal-title":"Int J Biol Macromol"},{"key":"2165_CR86","doi-asserted-by":"publisher","first-page":"646","DOI":"10.1007\/s12272-020-01234-1","volume":"43","author":"DZ Zhu","year":"2020","unstructured":"Zhu DZ, Wang YT, Zhuo YL, Zhu KJ, Wang XZ, Liu AJ (2020) Fucoidan inhibits LPS-induced acute lung injury in mice through regulating GSK-3\u03b2-Nrf2 signaling pathway. Arch Pharm Res 43:646\u2013654","journal-title":"Arch Pharm Res"}],"container-title":["Inflammopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10787-026-02165-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10787-026-02165-x","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10787-026-02165-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T05:07:30Z","timestamp":1776316050000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10787-026-02165-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,28]]},"references-count":83,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026,4]]}},"alternative-id":["2165"],"URL":"https:\/\/doi.org\/10.1007\/s10787-026-02165-x","relation":{"has-preprint":[{"id-type":"doi","id":"10.21203\/rs.3.rs-7981987\/v1","asserted-by":"object"}]},"ISSN":["0925-4692","1568-5608"],"issn-type":[{"value":"0925-4692","type":"print"},{"value":"1568-5608","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2,28]]},"assertion":[{"value":"29 October 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 February 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 February 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}