{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T16:35:36Z","timestamp":1792514136583,"version":"4.5.0"},"reference-count":47,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2026,3,5]],"date-time":"2026-03-05T00:00:00Z","timestamp":1772668800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,3,5]],"date-time":"2026-03-05T00:00:00Z","timestamp":1772668800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Inflammopharmacol"],"published-print":{"date-parts":[[2026,4]]},"DOI":"10.1007\/s10787-026-02166-w","type":"journal-article","created":{"date-parts":[[2026,3,5]],"date-time":"2026-03-05T15:06:11Z","timestamp":1772723171000},"page":"2547-2566","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Hydroxytyrosol-encapsulated solid lipid nanoparticles mitigate induced arthritis via modulating the cytokines and MMP-13 expression and downregulating oxidative stress in rats"],"prefix":"10.1007","volume":"34","author":[{"given":"Noor ul","family":"Huda","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aftab","family":"Ahmad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammad Anjum","family":"Zia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bushra","family":"Akhtar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,3,5]]},"reference":[{"key":"2166_CR1","doi-asserted-by":"publisher","first-page":"682","DOI":"10.3390\/antiox4040682","volume":"4","author":"L Abaza","year":"2015","unstructured":"Abaza L, Taamalli A, Nsir H, Zarrouk M (2015) Olive tree (Olea europeae L.) leaves: importance and advances in the analysis of phenolic compounds. Antioxidants 4:682\u2013698. https:\/\/doi.org\/10.3390\/antiox4040682","journal-title":"Antioxidants"},{"key":"2166_CR2","doi-asserted-by":"publisher","first-page":"109147","DOI":"10.1016\/j.cbpc.2021.109147","volume":"249","author":"\u00dc Acar","year":"2021","unstructured":"Acar \u00dc, \u0130nanan BE, Fahriye Zemheri Navruz and Sevdan Y\u0131lmaz (2021) Alterations in blood parameters, DNA damage, oxidative stress and antioxidant enzymes and immune-related genes expression in Nile tilapia (Oreochromis niloticus) exposed to glyphosate-based herbicide. Comp Biochem Physiol Part C Toxicol Pharmacol 249:109147\u2013109147. https:\/\/doi.org\/10.1016\/j.cbpc.2021.109147","journal-title":"Comp Biochem Physiol Part C Toxicol Pharmacol"},{"key":"2166_CR3","doi-asserted-by":"publisher","unstructured":"Ahn H, Baek G, Yoon M, Son J, You D, Yoon J, Cho H, Kim S, Cheong J, Eun J (2021) HMBS is the most suitable reference gene for RT-qPCR in human HCC tissues and blood samples. Oncol Lett 22. https:\/\/doi.org\/10.3892\/ol.2021.13052","DOI":"10.3892\/ol.2021.13052"},{"key":"2166_CR4","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2019.111864","volume":"238","author":"G Akhtar","year":"2019","unstructured":"Akhtar G, Shabbir A (2019) Urginea indica attenuated rheumatoid arthritis and inflammatory paw edema in diverse animal models of acute and chronic inflammation. J Ethnopharmacol 238:111864. https:\/\/doi.org\/10.1016\/j.jep.2019.111864","journal-title":"J Ethnopharmacol"},{"key":"2166_CR5","doi-asserted-by":"publisher","first-page":"49","DOI":"10.2174\/1871530321666210208211310","volume":"22","author":"MF Akhtar","year":"2022","unstructured":"Akhtar MF, Raza SA, Saleem A, Hamid I, Ashraf Baig MMF, Sharif A, Sohail K, Javaid Z, Saleem U, Rasul A (2022) Appraisal of anti-arthritic and anti-inflammatory potential of folkloric medicinal plant Peganum harmala. Endocr Metab Immune Disord Drug Targets 22:49\u201363. https:\/\/doi.org\/10.2174\/1871530321666210208211310","journal-title":"Endocr Metab Immune Disord Drug Targets"},{"key":"2166_CR6","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-023-41058-9","author":"M Akhtar","year":"2023","unstructured":"Akhtar M, Nosheen A, Keyani R, Yasmin H, Naz R, Mumtaz S, Hassan MN (2023) Biocontrol of Rhizoctonia solani in basmati rice by the application of Lactobacillus and Weissella spp. Sci Rep. https:\/\/doi.org\/10.1038\/s41598-023-41058-9","journal-title":"Sci Rep"},{"key":"2166_CR7","doi-asserted-by":"publisher","first-page":"3569","DOI":"10.3390\/molecules28083569","volume":"28","author":"TS Aldayel","year":"2023","unstructured":"Aldayel TS, Badran MM, Alomrani AH, AlFaris NA, AlTamimi JZ, Alqahtani AS, Nasr FA, Ghaffar S, Raha Orfali (2023) Chitosan-Coated Solid Lipid Nanoparticles as an Efficient Avenue for Boosted Biological Activities of Aloe perryi: Antioxidant, Antibacterial, and Anticancer Potential. Molecules 28:3569\u20133569. https:\/\/doi.org\/10.3390\/molecules28083569","journal-title":"Molecules"},{"key":"2166_CR8","doi-asserted-by":"publisher","first-page":"3085","DOI":"10.1007\/s10787-025-01787-x","volume":"33","author":"I Anwar","year":"2025","unstructured":"Anwar I, Sharif A, Ahmad M, Shabbir M, Akhtar B (2025) Farnesol alleviates inflammatory responses and oxidative stress in Freund\u2019s complete adjuvant induced arthritic rat model and associated risk factors of atherosclerosis. Inflammopharmacology 33:3085\u20133098. https:\/\/doi.org\/10.1007\/s10787-025-01787-x","journal-title":"Inflammopharmacology"},{"key":"2166_CR9","doi-asserted-by":"publisher","first-page":"10","DOI":"10.3892\/br.2024.1888","volume":"22","author":"Araya","year":"2024","unstructured":"Araya, Supawat, Nut Palachai and Jinatta Jittiwat (2024) Effect of galangin on oxidative stress, antioxidant defenses and mitochondrial dynamics in a rat model of focal cerebral ischemia. Biomedical Rep 22:10\u201310. https:\/\/doi.org\/10.3892\/br.2024.1888","journal-title":"Biomedical Rep"},{"key":"2166_CR10","doi-asserted-by":"publisher","first-page":"5365","DOI":"10.1007\/s10787-025-01907-7","volume":"33","author":"SK Awan","year":"2025","unstructured":"Awan SK, Sharif A, Akhtar B (2025) Mitigation of inflammation and oxidative stress in FCA-induced arthritic rat model through gum acacia intervention: a comprehensive in-vivo study. Inflammopharmacology 33:5365\u20135385. https:\/\/doi.org\/10.1007\/s10787-025-01907-7","journal-title":"Inflammopharmacology"},{"key":"2166_CR11","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics16121504","volume":"16","author":"WA Batarfi","year":"2024","unstructured":"Batarfi WA, Yunus MHM, Hamid AA, Lee YT, Maarof M (2024) Hydroxytyrosol: a promising therapeutic agent for mitigating inflammation and apoptosis. Pharmaceutics 16:1504. https:\/\/doi.org\/10.3390\/pharmaceutics16121504","journal-title":"Pharmaceutics"},{"key":"2166_CR12","doi-asserted-by":"publisher","first-page":"2290","DOI":"10.1016\/j.matpr.2022.04.916","volume":"65","author":"P Chaiya","year":"2022","unstructured":"Chaiya P, Senarat S, Phaechamud T, Narakornwit W (2022) In vitro anti-inflammatory activity using thermally inhibiting protein denaturation of egg albumin and antimicrobial activities of some organic solvents. Mater Today Proc 65:2290\u20132295. https:\/\/doi.org\/10.1016\/j.matpr.2022.04.916","journal-title":"Mater Today Proc"},{"key":"2166_CR13","doi-asserted-by":"publisher","DOI":"10.3390\/nano8010042","author":"S-Y Chuang","year":"2018","unstructured":"Chuang S-Y, Lin C-H, Huang T-H, Fang J-Y (2018) Lipid-based nanoparticles as a potential delivery approach in the treatment of rheumatoid arthritis. Nanomaterials. https:\/\/doi.org\/10.3390\/nano8010042","journal-title":"Nanomaterials"},{"key":"2166_CR14","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1016\/j.copbio.2011.09.006","volume":"23","author":"S Cicerale","year":"2012","unstructured":"Cicerale S, Lucas L, Keast R (2012) Antimicrobial, antioxidant and anti-inflammatory phenolic activities in extra virgin olive oil. Curr Opin Biotechnol 23:129\u2013135. https:\/\/doi.org\/10.1016\/j.copbio.2011.09.006","journal-title":"Curr Opin Biotechnol"},{"key":"2166_CR15","doi-asserted-by":"publisher","first-page":"3202","DOI":"10.3390\/app13053202","volume":"13","author":"H Derbel","year":"2023","unstructured":"Derbel H, Elleuch J, Mahfoudh W, Michaud P, Fendri I, Abdelkafi S (2023) In vitro antioxidant and anti-inflammatory activities of bioactive proteins and peptides from Rhodomonas sp. Appl Sci 13:3202\u20133202. https:\/\/doi.org\/10.3390\/app13053202","journal-title":"Appl Sci"},{"key":"2166_CR16","doi-asserted-by":"publisher","unstructured":"Djamila Zouheira Mo\u00efseL, Nchouwet NG, Nfor H, Da\u00efrou, Romuald J, Vandi T, Poualeu L, Tchamgoue AD, Tchokouaha R, Lea S, Agbor GA (2025) Toxicity Profile of Plectranthus glandulosus Hook. F. (Lamiaceae) Aqueous Extract, Hydro-Ethanolic Extract, and Ethyl Acetate Fraction. Biochemistry Research International, 2025. https:\/\/doi.org\/10.1155\/bri\/7453400","DOI":"10.1155\/bri\/7453400"},{"key":"2166_CR17","doi-asserted-by":"publisher","DOI":"10.1002\/adtp.202500249","author":"SA Fatima","year":"2025","unstructured":"Fatima SA, Akhtar B, Muhammad F, Aslam B, Shahid M (2025) Diosmetin-loaded solid lipid nanoparticles attenuate induced arthritis via cytokines modulation and antioxidant activity. Adv Ther. https:\/\/doi.org\/10.1002\/adtp.202500249","journal-title":"Adv Ther"},{"key":"2166_CR18","doi-asserted-by":"publisher","DOI":"10.1007\/s10787-025-01653-w","author":"SA Fatima","year":"2025","unstructured":"Fatima SA, Akhtar B, Sharif A, Khan MI, Shahid M, Anjum F, Hussain F, Mobashar A, Ashraf M (2025b) Implications of nociceptor receptors and immune modulation: emerging therapeutic targets for autoimmune diseases. Inflammopharmacology. https:\/\/doi.org\/10.1007\/s10787-025-01653-w","journal-title":"Inflammopharmacology"},{"key":"2166_CR19","doi-asserted-by":"publisher","DOI":"10.3390\/molecules23123212","volume":"23","author":"R Fuccelli","year":"2018","unstructured":"Fuccelli R, Fabiani R, Rosignoli P (2018) Hydroxytyrosol exerts anti-inflammatory and anti-oxidant activities in a mouse model of systemic inflammation. Molecules 23:3212. https:\/\/doi.org\/10.3390\/molecules23123212","journal-title":"Molecules"},{"key":"2166_CR20","doi-asserted-by":"publisher","DOI":"10.1007\/s10787-022-01118-4","author":"A Hannan","year":"2022","unstructured":"Hannan A, Akhtar B, Sharif A, Anjum F, Pasha I, Khan A, Akhtar MF, Saleem A (2022) Quercetin-loaded chitosan nanoparticles ameliorate adjuvant-induced arthritis in rats by regulating anti-oxidant enzymes and downregulating pro- and inflammatory cytokines. Inflammopharmacology. https:\/\/doi.org\/10.1007\/s10787-022-01118-4","journal-title":"Inflammopharmacology"},{"issue":"1","key":"2166_CR21","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1186\/s42269-024-01189-z","volume":"48","author":"MH Hadwan","year":"2024","unstructured":"Hadwan MH, Alta\u2019ee AH, Mohammed RM, Hadwan AM, Al-Kawaz HS, Al Talebi ZA (2024) An efficient protocol for quantifying catalase activity in biological samples. Bull Natl Res Cent 48(1):34. https:\/\/doi.org\/10.1186\/s42269-024-01189-z","journal-title":"Bull Natl Res Cent"},{"key":"2166_CR22","doi-asserted-by":"publisher","first-page":"6669","DOI":"10.1007\/s10787-025-01930-8","volume":"33","author":"A Iqra, Sharif","year":"2025","unstructured":"Iqra, Sharif A, Akhtar B, Shao C, Wang S, Younas A (2025) Quinic acid alleviates inflammatory responses and oxidative stress in Freund\u2019s complete adjuvant-induced arthritic rat model and associated risk factors of atherosclerosis. Inflammopharmacology 33:6669\u20136690. https:\/\/doi.org\/10.1007\/s10787-025-01930-8","journal-title":"Inflammopharmacology"},{"key":"2166_CR23","doi-asserted-by":"publisher","DOI":"10.1007\/s10787-024-01618-5","author":"Z Kanwal","year":"2024","unstructured":"Kanwal Z, Akhtar B, Aslam B, Arshad MI (2024) Carvone-loaded chitosan nanoparticles alleviate joint destruction by downregulating the expression of pro, inflammatory cytokines and MMP-13 in adjuvant-induced rat model. Inflammopharmacology. https:\/\/doi.org\/10.1007\/s10787-024-01618-5","journal-title":"Inflammopharmacology"},{"key":"2166_CR24","doi-asserted-by":"publisher","first-page":"473","DOI":"10.1016\/j.colsurfb.2015.02.046","volume":"128","author":"HR Kelidari","year":"2015","unstructured":"Kelidari HR, Saeedi M, \u00c2kbari J, Morteza-Semnani K, Gill P, Valizadeh H, Nokhodchi A (2015) Formulation optimization and in vitro skin penetration of spironolactone loaded solid lipid nanoparticles. Colloids Surf B 128:473\u2013479. https:\/\/doi.org\/10.1016\/j.colsurfb.2015.02.046","journal-title":"Colloids Surf B"},{"key":"2166_CR25","doi-asserted-by":"publisher","DOI":"10.21608\/fsrt.2022.146471.1066","author":"h Khaled","year":"2022","unstructured":"Khaled h, Hanna J, Shoukry NMM, Darwesh A, Fares n (2022) Therapeutic potential of Withania somnifera extract on experimental model of arthritis in rats: histological study. Frontiers in Scientific Research and Technology. https:\/\/doi.org\/10.21608\/fsrt.2022.146471.1066","journal-title":"Frontiers in Scientific Research and Technology"},{"key":"2166_CR26","doi-asserted-by":"publisher","DOI":"10.4137\/cmamd.s5558","volume":"6","author":"P Kumar","year":"2013","unstructured":"Kumar P, Banik S (2013) Pharmacotherapy options in rheumatoid arthritis. Clinical Medicine Insights: Arthritis and Musculoskeletal Disorders 6:CMAMD.S5558. https:\/\/doi.org\/10.4137\/cmamd.s5558","journal-title":"Clinical Medicine Insights: Arthritis and Musculoskeletal Disorders"},{"key":"2166_CR27","doi-asserted-by":"publisher","first-page":"3275","DOI":"10.1007\/s00210-023-02814-w","volume":"397","author":"MU Mazhar","year":"2023","unstructured":"Mazhar MU, Naz S, Zulfiqar T, Khan JZ, Ghazanfar S, Tipu MK (2023) Immunostimulant, hepatoprotective, and nephroprotective potential of Bacillus subtilis (NMCC-path-14) in comparison to dexamethasone in alleviating CFA-induced arthritis. Naunyn-Schmiedebergs Arch Pharmacol 397:3275\u20133299. https:\/\/doi.org\/10.1007\/s00210-023-02814-w","journal-title":"Naunyn-Schmiedebergs Arch Pharmacol"},{"key":"2166_CR28","doi-asserted-by":"publisher","first-page":"132","DOI":"10.1016\/j.semarthrit.2008.08.003","volume":"39","author":"LW Moreland","year":"2009","unstructured":"Moreland LW, Curtis JR (2009) Systemic nonarticular manifestations of rheumatoid arthritis: focus on inflammatory mechanisms. Semin Arthritis Rheum 39:132\u2013143. https:\/\/doi.org\/10.1016\/j.semarthrit.2008.08.003","journal-title":"Semin Arthritis Rheum"},{"key":"2166_CR29","doi-asserted-by":"publisher","unstructured":"Moreno-Loshuertos R, Fern\u00e1ndez-Silva P (2024) Isolation of Mitochondria for Mitochondrial Supercomplex Analysis from Small Tissue and Cell Culture Samples. J Visualized Experiments [online] 207. https:\/\/doi.org\/10.3791\/66771","DOI":"10.3791\/66771"},{"key":"2166_CR30","unstructured":"Nath B, Barbhuiya TF (2014) Studies on the density and surface area of nanoparticles from Camellia sinensis, A natural source. Journal of Chemical and Pharmaceutical Research, [online] 6(11). Available at: https:\/\/www.jocpr.com\/abstract\/studies-on-the-density-and-surface-area-of-nanoparticles-from-camellia-sinensis-a-natural-source-6528.html [Accessed 4 Dec. 2025]"},{"key":"2166_CR31","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0260423","volume":"16","author":"ASM Noh","year":"2021","unstructured":"Noh ASM, Chuan TD, Khir NAM, Zin AAM, Ghazali AK, Long I, Ab Aziz CB, Ismail CAN (2021) Effects of different doses of complete Freund\u2019s adjuvant on nociceptive behaviour and inflammatory parameters in polyarthritic rat model mimicking rheumatoid arthritis. PLoS One 16:0260423. https:\/\/doi.org\/10.1371\/journal.pone.0260423","journal-title":"PLoS One"},{"key":"2166_CR32","doi-asserted-by":"publisher","DOI":"10.24976\/discov.med.202335178.68","volume":"35","author":"E Pannucci","year":"2023","unstructured":"Pannucci E, Spagnuolo L, De Gara L, Santi L, Dugo L (2023) Phenolic compounds as preventive and therapeutic agents in diabetes-related oxidative stress, inflammation, advanced glycation end-products production and insulin sensitivity. Discovery Med 35:715. https:\/\/doi.org\/10.24976\/discov.med.202335178.68","journal-title":"Discovery Med"},{"key":"2166_CR33","doi-asserted-by":"publisher","first-page":"764","DOI":"10.1007\/s11947-020-02407-y","volume":"13","author":"F Paulo","year":"2020","unstructured":"Paulo F, Santos L (2020) Encapsulation of the antioxidant tyrosol and characterization of loaded microparticles: an integrative approach on the study of the polymer-carriers and loading contents. Food Bioprocess Technol 13:764\u2013785. https:\/\/doi.org\/10.1007\/s11947-020-02407-y","journal-title":"Food Bioprocess Technol"},{"key":"2166_CR34","doi-asserted-by":"publisher","first-page":"8581","DOI":"10.3390\/ijerph110808581","volume":"11","author":"C Pizzol","year":"2014","unstructured":"Pizzol C, Filippin-Monteiro F, Restrepo J, Pittella F, Silva A, Alves de Souza P, Machado de Campos A, Creczynski-Pasa T (2014) Influence of surfactant and lipid type on the physicochemical properties and biocompatibility of solid lipid nanoparticles. Int J Environ Res Public Health 11:8581\u20138596. https:\/\/doi.org\/10.3390\/ijerph110808581","journal-title":"Int J Environ Res Public Health"},{"key":"2166_CR35","doi-asserted-by":"publisher","unstructured":"Prasad P, Verma S, Surbhi, Ganguly NK, Chaturvedi V, Mittal SA (2022) Rheumatoid arthritis: advances in treatment strategies. Mol Cell Biochem 478. https:\/\/doi.org\/10.1007\/s11010-022-04492-3","DOI":"10.1007\/s11010-022-04492-3"},{"key":"2166_CR36","doi-asserted-by":"publisher","unstructured":"Rom\u00e3o VC, Fonseca JE (2021) Etiology and risk factors for rheumatoid arthritis: a state-of-the-art review. Front Med 8(689698). https:\/\/doi.org\/10.3389\/fmed.2021.689698","DOI":"10.3389\/fmed.2021.689698"},{"key":"2166_CR37","doi-asserted-by":"publisher","first-page":"1079","DOI":"10.1007\/s10787-022-00977-1","volume":"30","author":"MU Saleem","year":"2022","unstructured":"Saleem MU, Muhammad F, Sharif A, Arshad MI, Akhtar K, Javed Y, Akhtar B (2022) Methotrexate-loaded biodegradable nanoparticles exert anti-arthritic effect by downregulating pro-inflammatory cytokines in Freund\u2019s complete adjuvant-induced arthritic rats. Inflammopharmacology 30:1079\u20131091. https:\/\/doi.org\/10.1007\/s10787-022-00977-1","journal-title":"Inflammopharmacology"},{"key":"2166_CR38","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2014\/719486","volume":"2014","author":"L Salerno","year":"2014","unstructured":"Salerno L, Modica MN, Pittal\u00e0 V, Romeo G, Siracusa MA, Di Giacomo C, Sorrenti V, Acquaviva R (2014) Antioxidant activity and phenolic content of microwave-assistedSolanum melongena extracts. Sci World J 2014:1\u20136. https:\/\/doi.org\/10.1155\/2014\/719486","journal-title":"Sci World J"},{"key":"2166_CR39","doi-asserted-by":"publisher","unstructured":"Samuel B, Esho BA (2021) Membrane Stabilization and Inhibition of Protein Denaturation as Mechanisms of the Anti-Inflammatory Activity of some Plant Species. DOAJ (DOAJ: Directory of Open Access Journals. https:\/\/doi.org\/10.30476\/tips.2021.93160.1118. Kemi Feyisayo Akinwunmi and Wande Michael Oluyemi","DOI":"10.30476\/tips.2021.93160.1118"},{"key":"2166_CR40","doi-asserted-by":"publisher","DOI":"10.1016\/j.lwt.2021.111932","volume":"150","author":"AM Shraim","year":"2021","unstructured":"Shraim AM, Ahmed TA, Rahman MM, Hijji YM (2021) Determination of total flavonoid content by aluminum chloride assay: a critical evaluation. LWT 150:111932. https:\/\/doi.org\/10.1016\/j.lwt.2021.111932","journal-title":"LWT"},{"key":"2166_CR41","doi-asserted-by":"publisher","first-page":"335","DOI":"10.1007\/s13105-012-0216-5","volume":"69","author":"AK Shrivastava","year":"2012","unstructured":"Shrivastava AK, Pandey A (2012) Inflammation and rheumatoid arthritis. J Physiol Biochem 69:335\u2013347. https:\/\/doi.org\/10.1007\/s13105-012-0216-5","journal-title":"J Physiol Biochem"},{"key":"2166_CR42","doi-asserted-by":"publisher","DOI":"10.3390\/agriculture11010068","volume":"11","author":"VS Singh","year":"2021","unstructured":"Singh VS, Dhawale SC, Shakeel F, Faiyazuddin M, Alshehri S (2021) Antiarthritic potential of Calotropis procera leaf fractions in FCA-induced arthritic rats: involvement of cellular inflammatory mediators and other biomarkers. Agriculture 11:68. https:\/\/doi.org\/10.3390\/agriculture11010068","journal-title":"Agriculture"},{"key":"2166_CR43","doi-asserted-by":"publisher","first-page":"633","DOI":"10.3390\/antiox12030633","volume":"12","author":"E Subroto","year":"2023","unstructured":"Subroto E, Andoyo R, Indiarto R (2023) Solid lipid nanoparticles: review of the current research on encapsulation and delivery systems for active and antioxidant compounds. Antioxidants 12:633. https:\/\/doi.org\/10.3390\/antiox12030633","journal-title":"Antioxidants"},{"key":"2166_CR44","doi-asserted-by":"publisher","first-page":"3119","DOI":"10.1007\/s10787-025-01732-y","volume":"33","author":"F Waseem","year":"2025","unstructured":"Waseem F, Sharif A, Shabbir M, Akhtar B, Shah A, None S, Arshad A, Basheer E, Hanif MA, Ali M (2025) N-dimethyl chalcone facilitated augmentation of IL-10 and diminution of TNF-\u03b1, IL-1\u03b2, IL-6, NF\u03baB, and COX-2 in FCA-induced arthritic rat model. Inflammopharmacology 33:3119\u20133134. https:\/\/doi.org\/10.1007\/s10787-025-01732-y","journal-title":"Inflammopharmacology"},{"key":"2166_CR45","doi-asserted-by":"publisher","DOI":"10.1186\/s13020-023-00833-6","author":"Q Xu","year":"2023","unstructured":"Xu Q, Kong H, Ren S, Meng F, Liu R, Jin H, Zhang J (2023) Coix seed oil alleviates synovial angiogenesis through suppressing HIF-1\u03b1\/VEGF-A signaling pathways via SIRT1 in collagen-induced arthritis rats. Chin Med. https:\/\/doi.org\/10.1186\/s13020-023-00833-6","journal-title":"Chin Med"},{"key":"2166_CR46","doi-asserted-by":"publisher","first-page":"35875","DOI":"10.1021\/acsomega.2c04407","volume":"7","author":"S Yeo","year":"2022","unstructured":"Yeo S, Kim MJ, Shim YK, Yoon I, Lee WK (2022) Solid lipid nanoparticles of curcumin designed for enhanced bioavailability and anticancer efficiency. ACS Omega 7:35875\u201335884. https:\/\/doi.org\/10.1021\/acsomega.2c04407","journal-title":"ACS Omega"},{"key":"2166_CR47","doi-asserted-by":"publisher","first-page":"285","DOI":"10.1007\/978-981-16-5003-1_9","volume":"5","author":"J Zhou","year":"2022","unstructured":"Zhou J, Wang F, Qu Y, Sun H, Liu Z (2022) Lesions of Bones and Joints Associated with Rheumatism. Radiol Infect Inflamm Dis 5:285\u2013332. https:\/\/doi.org\/10.1007\/978-981-16-5003-1_9","journal-title":"Radiol Infect Inflamm Dis"}],"container-title":["Inflammopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10787-026-02166-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10787-026-02166-w","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10787-026-02166-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T05:08:00Z","timestamp":1776316080000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10787-026-02166-w"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,5]]},"references-count":47,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026,4]]}},"alternative-id":["2166"],"URL":"https:\/\/doi.org\/10.1007\/s10787-026-02166-w","relation":{},"ISSN":["0925-4692","1568-5608"],"issn-type":[{"value":"0925-4692","type":"print"},{"value":"1568-5608","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3,5]]},"assertion":[{"value":"22 December 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 February 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 March 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"Ethical approval for the study was taken from the relevant institutional ethics committee.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical Approval"}},{"value":"All in vivo experimental procedures were performed in accordance with the National Biosafety Rules (2005), Punjab Animal Health Act (2019), Punjab Biosafety Rules (2014) and institutional bioethical guidelines. Prior approval was granted by the Institutional Bioethics Committee (Approval No. D. No. 2288\/ORIC).","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Human\/Animal Rights"}}]}}