{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T05:49:58Z","timestamp":1776318598487,"version":"3.50.1"},"reference-count":41,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T00:00:00Z","timestamp":1773014400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T00:00:00Z","timestamp":1773014400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Inflammopharmacol"],"published-print":{"date-parts":[[2026,4]]},"DOI":"10.1007\/s10787-026-02179-5","type":"journal-article","created":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T14:18:35Z","timestamp":1773065915000},"page":"2625-2637","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Ethanolic extract of propolis attenuates inflammation and promotes mucosal repair in an indomethacin-induced murine model of enteropathy"],"prefix":"10.1007","volume":"34","author":[{"given":"Oussama","family":"Medjeber","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hayet","family":"Rafa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kahina","family":"Touri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arezki","family":"Samer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sabrina","family":"Bouhara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zineb","family":"Djeraba","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chafia","family":"Touil-Boukoffa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2026,3,9]]},"reference":[{"key":"2179_CR1","unstructured":"Abcam (2025) Immunocytochemistry and immunofluorescence protocol Procedure for staining of cell cultures using immunofluorescence"},{"key":"2179_CR2","doi-asserted-by":"publisher","first-page":"1307394","DOI":"10.3389\/FMED.2024.1307394\/EPUB","volume":"11","author":"I Aggeletopoulou","year":"2024","unstructured":"Aggeletopoulou I, Kalafateli M, Tsounis EP, Triantos C (2024) Exploring the role of IL-1\u03b2 in inflammatory bowel disease pathogenesis. Front Med (Lausanne) 11:1307394. https:\/\/doi.org\/10.3389\/FMED.2024.1307394\/EPUB","journal-title":"Front Med (Lausanne)"},{"key":"2179_CR3","doi-asserted-by":"publisher","first-page":"3809","DOI":"10.1007\/s10787-024-01574-0","volume":"32","author":"H Aghamiri","year":"2024","unstructured":"Aghamiri H, Mohammadgholi-Beiki A, Rashidian R et al (2024) Zhumeria majdae essential oil attenuates TNBS-induced colitis in rats by regulating inflammatory and apoptotic pathways. Inflammopharmacology 32:3809\u20133824. https:\/\/doi.org\/10.1007\/s10787-024-01574-0","journal-title":"Inflammopharmacology"},{"key":"2179_CR4","doi-asserted-by":"publisher","first-page":"425","DOI":"10.1016\/j.cellsig.2010.10.017","volume":"23","author":"D Arias-Salvatierra","year":"2011","unstructured":"Arias-Salvatierra D, Silbergeld EK, Acosta-Saavedra LC, Calderon-Aranda ES (2011) Role of nitric oxide produced by iNOS through NF-\u03baB pathway in migration of cerebellar granule neurons induced by Lipopolysaccharide. Cell Signal 23:425\u2013435. https:\/\/doi.org\/10.1016\/j.cellsig.2010.10.017","journal-title":"Cell Signal"},{"key":"2179_CR5","doi-asserted-by":"publisher","first-page":"591","DOI":"10.1111\/J.1365-2796.2008.01953.X","volume":"263","author":"I Atreya","year":"2008","unstructured":"Atreya I, Atreya R, Neurath MF (2008) NF-kappaB in inflammatory bowel disease. J Intern Med 263:591\u2013596. https:\/\/doi.org\/10.1111\/J.1365-2796.2008.01953.X","journal-title":"J Intern Med"},{"key":"2179_CR6","doi-asserted-by":"publisher","first-page":"1358","DOI":"10.1136\/GUT.31.12.1358","volume":"31","author":"AK Banerjee","year":"1990","unstructured":"Banerjee AK, Peters TJ (1990) Experimental non-steroidal anti-inflammatory drug-induced enteropathy in the rat: similarities to inflammatory bowel disease and effect of thromboxane synthetase inhibitors. Gut 31:1358. https:\/\/doi.org\/10.1136\/GUT.31.12.1358","journal-title":"Gut"},{"key":"2179_CR7","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1007\/s00535-008-2266-6","volume":"44","author":"I Bjarnason","year":"2009","unstructured":"Bjarnason I, Takeuchi K (2009) Intestinal permeability in the pathogenesis of NSAID-induced enteropathy. J Gastroenterol 44:23\u201329. https:\/\/doi.org\/10.1007\/s00535-008-2266-6","journal-title":"J Gastroenterol"},{"key":"2179_CR8","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1016\/j.jep.2013.06.004","volume":"149","author":"MC B\u00fafalo","year":"2013","unstructured":"B\u00fafalo MC, Ferreira I, Costa G et al (2013) Propolis and its constituent caffeic acid suppress LPS-stimulated pro-inflammatory response by blocking NF-\u03baB and MAPK activation in macrophages. J Ethnopharmacol 149:84\u201392. https:\/\/doi.org\/10.1016\/j.jep.2013.06.004","journal-title":"J Ethnopharmacol"},{"key":"2179_CR9","doi-asserted-by":"publisher","unstructured":"da Silva LM, de Souza P, Jaouni SK, Al et al (2018) Propolis and its potential to treat gastrointestinal disorders. Evid Based Complement Alternat Med 2018:2035820. https:\/\/doi.org\/10.1155\/2018\/2035820","DOI":"10.1155\/2018\/2035820"},{"key":"2179_CR10","doi-asserted-by":"publisher","first-page":"C161","DOI":"10.1016\/j.jacc.2018.08.732","volume":"72","author":"T He","year":"2018","unstructured":"He T, Sui X, Sun W et al (2018) The protective effects and mechanism of total flavonoids of propolis on pathological cardiac hypertrophy and heart failure in mice. J Am Coll Cardiol 72:C161. https:\/\/doi.org\/10.1016\/j.jacc.2018.08.732","journal-title":"J Am Coll Cardiol"},{"key":"2179_CR11","doi-asserted-by":"publisher","first-page":"107036","DOI":"10.1016\/j.jff.2025.107036","volume":"134","author":"H Heshmatipour","year":"2025","unstructured":"Heshmatipour H, Vajdi M, Tabrizi FPF et al (2025) Effects of propolis supplementation on inflammation and oxidative stress markers: a GRADE-assessed systematic review and meta-analysis of clinical trials. J Funct Foods 134:107036. https:\/\/doi.org\/10.1016\/j.jff.2025.107036","journal-title":"J Funct Foods"},{"key":"2179_CR12","doi-asserted-by":"publisher","first-page":"3621","DOI":"10.3390\/IJMS26083621","volume":"26","author":"P Ioannou","year":"2025","unstructured":"Ioannou P, Katsoulieris E, Afratis NA (2025) Matrix dynamics and microbiome crosstalk: matrix metalloproteinases as key players in disease and therapy. Int J Mol Sci 2025 26:3621. https:\/\/doi.org\/10.3390\/IJMS26083621","journal-title":"Int J Mol Sci 2025"},{"key":"2179_CR13","doi-asserted-by":"publisher","first-page":"742","DOI":"10.1093\/IBD\/IZX100","volume":"24","author":"SR Knowles","year":"2018","unstructured":"Knowles SR, Graff LA, Wilding H et al (2018) Quality of life in inflammatory bowel disease: a systematic review and meta-analyses-part I. Inflamm Bowel Dis 24:742\u2013751. https:\/\/doi.org\/10.1093\/IBD\/IZX100","journal-title":"Inflamm Bowel Dis"},{"key":"2179_CR14","doi-asserted-by":"publisher","first-page":"894","DOI":"10.1023\/A:1014725024519","volume":"47","author":"T Kunikata","year":"2002","unstructured":"Kunikata T, Tanaka A, Miyazawa T et al (2002) 16,16-dimethyl prostaglandin E2 inhibits indomethacin-induced small intestinal lesions through EP3 and EP4 receptors. Dig Dis Sci 47:894\u2013904. https:\/\/doi.org\/10.1023\/A:1014725024519","journal-title":"Dig Dis Sci"},{"key":"2179_CR15","doi-asserted-by":"publisher","first-page":"138","DOI":"10.5946\/ce.2012.45.2.138","volume":"45","author":"YJ Lim","year":"2012","unstructured":"Lim YJ, Yang C-H (2012) Non-Steroidal Anti-Inflammatory Drug-Induced Enteropathy. Clin Endosc 45:138. https:\/\/doi.org\/10.5946\/ce.2012.45.2.138","journal-title":"Clin Endosc"},{"key":"2179_CR16","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2015.00551","author":"I Loddo","year":"2015","unstructured":"Loddo I, Romano C (2015) Inflammatory bowel disease: genetics, epigenetics, and pathogenesis. Front Immunol https:\/\/doi.org\/10.3389\/fimmu.2015.00551","journal-title":"Front Immunol"},{"key":"2179_CR17","doi-asserted-by":"publisher","first-page":"1469","DOI":"10.1007\/s10787-018-0460-6","volume":"26","author":"O Medjeber","year":"2018","unstructured":"Medjeber O, Touri K, Rafa H et al (2018) Ex vivo immunomodulatory effect of ethanolic extract of propolis during Celiac Disease: involvement of nitric oxide pathway. Inflammopharmacology 26:1469\u20131481. https:\/\/doi.org\/10.1007\/s10787-018-0460-6","journal-title":"Inflammopharmacology"},{"key":"2179_CR18","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1111\/apt.12160","volume":"37","author":"T Moln\u00e1r","year":"2013","unstructured":"Moln\u00e1r T, Lakatos PL, Farkas K et al (2013) Predictors of relapse in patients with Crohn\u2019s disease in remission after 1 year of biological therapy. Aliment Pharmacol Ther 37:225\u2013233. https:\/\/doi.org\/10.1111\/apt.12160","journal-title":"Aliment Pharmacol Ther"},{"key":"2179_CR19","doi-asserted-by":"publisher","first-page":"1223","DOI":"10.1038\/s41598-018-38125-x","volume":"9","author":"TL Morhardt","year":"2019","unstructured":"Morhardt TL, Hayashi A, Ochi T et al (2019) IL-10 produced by macrophages regulates epithelial integrity in the small intestine. Sci Rep 9:1223. https:\/\/doi.org\/10.1038\/s41598-018-38125-x","journal-title":"Sci Rep"},{"key":"2179_CR20","doi-asserted-by":"publisher","first-page":"1722","DOI":"10.1007\/BF01303184","volume":"38","author":"SNS Murthy","year":"1993","unstructured":"Murthy SNS, Cooper HS, Shim H et al (1993) Treatment of dextran sulfate sodium-induced murine colitis by intracolonic cyclosporin. Dig Dis Sci 38:1722\u20131734. https:\/\/doi.org\/10.1007\/BF01303184","journal-title":"Dig Dis Sci"},{"key":"2179_CR21","doi-asserted-by":"publisher","first-page":"e41120","DOI":"10.7759\/CUREUS.41120","volume":"15","author":"MA Muzammil","year":"2023","unstructured":"Muzammil MA, Fariha F, Patel T et al (2023) Advancements in inflammatory bowel disease: a narrative review of diagnostics, management, epidemiology, prevalence, patient outcomes, quality of life, and clinical presentation. Cureus 15:e41120. https:\/\/doi.org\/10.7759\/CUREUS.41120","journal-title":"Cureus"},{"key":"2179_CR22","doi-asserted-by":"publisher","first-page":"853","DOI":"10.1016\/S2468-1253(23)00154-1","volume":"8","author":"TL Parigi","year":"2023","unstructured":"Parigi TL, D\u2019Amico F, Abreu MT et al (2023) Difficult-to-treat inflammatory bowel disease: results from an international consensus meeting. Lancet Gastroenterol Hepatol 8:853\u2013859. https:\/\/doi.org\/10.1016\/S2468-1253(23)00154-1","journal-title":"Lancet Gastroenterol Hepatol"},{"key":"2179_CR23","doi-asserted-by":"publisher","first-page":"296","DOI":"10.1016\/j.ejphar.2008.02.067","volume":"587","author":"N Paulino","year":"2008","unstructured":"Paulino N, Abreu SRL, Uto Y et al (2008) Anti-inflammatory effects of a bioavailable compound, Artepillin C, in Brazilian propolis. Eur J Pharmacol 587:296\u2013301. https:\/\/doi.org\/10.1016\/j.ejphar.2008.02.067","journal-title":"Eur J Pharmacol"},{"key":"2179_CR25","doi-asserted-by":"publisher","unstructured":"Rafa H, Saoula H, Belkhelfa M et al (2013) IL-23\/IL-17A axis correlates with the nitric oxide pathway in inflammatory bowel disease: immunomodulatory effect of retinoic acid. 33:355\u2013368. https:\/\/doi.org\/10.1089\/JIR.2012.0063. https:\/\/home.liebertpub.com\/jir","DOI":"10.1089\/JIR.2012.0063"},{"key":"2179_CR24","doi-asserted-by":"publisher","first-page":"7353252","DOI":"10.1155\/2017\/7353252","volume":"2017","author":"H Rafa","year":"2017","unstructured":"Rafa H, Benkhelifa S, Aityounes S et al (2017) All-trans retinoic acid modulates TLR4\/NF-\u03baB signaling pathway targeting TNF-\u03b1 and nitric oxide synthase 2 expression in colonic mucosa during ulcerative colitis and colitis associated cancer. Mediators Inflamm 2017:7353252. https:\/\/doi.org\/10.1155\/2017\/7353252","journal-title":"Mediators Inflamm"},{"key":"2179_CR26","doi-asserted-by":"publisher","first-page":"323","DOI":"10.1038\/S41575-020-0273-0;SUBJMETA","volume":"17","author":"A Salas","year":"2020","unstructured":"Salas A, Hernandez-Rocha C, Duijvestein M et al (2020) JAK\u2013STAT pathway targeting for the treatment of inflammatory bowel disease. Nat Rev Gastroenterol Hepatol 17:323\u2013337. https:\/\/doi.org\/10.1038\/S41575-020-0273-0;SUBJMETA","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"2179_CR27","doi-asserted-by":"publisher","first-page":"1685","DOI":"10.1007\/s10787-022-00996-y","volume":"30","author":"A Samer","year":"2022","unstructured":"Samer A, Toumi R, Soufli I, Touil-Boukoffa C (2022) Cell-free probiotic supernatant (CFS) treatment alleviates indomethacin-induced enterocolopathy in BALB\/c mice by down-modulating inflammatory response and oxidative stress: potential alternative targeted treatment. Inflammopharmacology 30:1685\u20131703. https:\/\/doi.org\/10.1007\/s10787-022-00996-y","journal-title":"Inflammopharmacology"},{"key":"2179_CR28","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.jep.2007.05.012","volume":"113","author":"JM Sforcin","year":"2007","unstructured":"Sforcin JM (2007) Propolis and the immune system: a review. J Ethnopharmacol 113:1\u201314. https:\/\/doi.org\/10.1016\/j.jep.2007.05.012","journal-title":"J Ethnopharmacol"},{"key":"2179_CR29","doi-asserted-by":"publisher","first-page":"894","DOI":"10.1002\/ptr.5605","volume":"30","author":"JM Sforcin","year":"2016","unstructured":"Sforcin JM (2016) Biological properties and therapeutic applications of propolis. Phytother Res 30:894\u2013905. https:\/\/doi.org\/10.1002\/ptr.5605","journal-title":"Phytother Res"},{"key":"2179_CR30","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1007\/S12079-022-00695-X","volume":"17","author":"A Shahini","year":"2022","unstructured":"Shahini A, Shahini A (2022) Role of interleukin-6-mediated inflammation in the pathogenesis of inflammatory bowel disease: focus on the available therapeutic approaches and gut microbiome. J Cell Commun Signal 17:55. https:\/\/doi.org\/10.1007\/S12079-022-00695-X","journal-title":"J Cell Commun Signal"},{"key":"2179_CR31","doi-asserted-by":"publisher","first-page":"446","DOI":"10.5217\/ir.2017.15.4.446","volume":"15","author":"SJ Shin","year":"2017","unstructured":"Shin SJ, Noh C-K, Lim SG et al (2017) Non-steroidal anti-inflammatory drug-induced enteropathy. Intest Res 15:446. https:\/\/doi.org\/10.5217\/ir.2017.15.4.446","journal-title":"Intest Res"},{"key":"2179_CR32","doi-asserted-by":"publisher","unstructured":"Silva-Carvalho R, Baltazar F, Almeida-Aguiar C (2015) Propolis: a complex natural product with a plethora of biological activities that can be explored for drug development. Evid Based Complement Altern Med 2015:1\u201329. https:\/\/doi.org\/10.1155\/2015\/206439","DOI":"10.1155\/2015\/206439"},{"key":"2179_CR33","doi-asserted-by":"publisher","first-page":"100204","DOI":"10.1016\/j.eurox.2023.100204","volume":"19","author":"H Situmorang","year":"2023","unstructured":"Situmorang H, Hestiantoro A, Purbadi S et al (2023) Sulawesi propolis induces higher apoptotic activity and lower inflammatory activity in a rat endometriosis model. Eur J Obstet Gynecol Reprod Biol X 19:100204. https:\/\/doi.org\/10.1016\/j.eurox.2023.100204","journal-title":"Eur J Obstet Gynecol Reprod Biol X"},{"key":"2179_CR34","doi-asserted-by":"publisher","first-page":"353","DOI":"10.4292\/WJGPT.V7.I3.353","volume":"7","author":"I Soufli","year":"2016","unstructured":"Soufli I, Toumi R, Rafa H, Touil-Boukoffa C (2016) Overview of cytokines and nitric oxide involvement in immuno-pathogenesis of inflammatory bowel diseases. World J Gastrointest Pharmacol Ther 7:353. https:\/\/doi.org\/10.4292\/WJGPT.V7.I3.353","journal-title":"World J Gastrointest Pharmacol Ther"},{"key":"2179_CR35","doi-asserted-by":"publisher","first-page":"1293","DOI":"10.1007\/s10787-018-0487-8","volume":"26","author":"K Touri","year":"2018","unstructured":"Touri K, Belguendouz H, Medjeber O et al (2018) Propolis modulates NOS2\/arginase-1 pathway in tropomyosin-induced experimental autoimmune uveitis. Inflammopharmacology 26:1293\u20131303. https:\/\/doi.org\/10.1007\/s10787-018-0487-8","journal-title":"Inflammopharmacology"},{"key":"2179_CR36","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1016\/j.jchromb.2006.07.054","volume":"851","author":"D Tsikas","year":"2007","unstructured":"Tsikas D (2007) Analysis of nitrite and nitrate in biological fluids by assays based on the Griess reaction: appraisal of the Griess reaction in the l-arginine\/nitric oxide area of research. J Chromatogr B 851:51\u201370. https:\/\/doi.org\/10.1016\/j.jchromb.2006.07.054","journal-title":"J Chromatogr B"},{"key":"2179_CR37","doi-asserted-by":"publisher","first-page":"427","DOI":"10.1016\/J.EJPHAR.2004.07.042","volume":"500","author":"BJR Whittle","year":"2004","unstructured":"Whittle BJR (2004) Mechanisms underlying intestinal injury induced by anti-inflammatory COX inhibitors. Eur J Pharmacol 500:427\u2013439. https:\/\/doi.org\/10.1016\/J.EJPHAR.2004.07.042","journal-title":"Eur J Pharmacol"},{"key":"2179_CR38","doi-asserted-by":"publisher","first-page":"40317","DOI":"10.1038\/srep40317","volume":"7","author":"X Xiao","year":"2017","unstructured":"Xiao X, Nakatsu G, Jin Y et al (2017) Gut microbiota mediates protection against enteropathy induced by indomethacin. Sci Rep 7:40317. https:\/\/doi.org\/10.1038\/srep40317","journal-title":"Sci Rep"},{"key":"2179_CR39","doi-asserted-by":"publisher","unstructured":"Yan J, Bin, Luo MM, Chen ZY, He BH (2020) The function and role of the Th17\/Treg cell balance in inflammatory bowel disease. J Immunol Res 2020:8813558. https:\/\/doi.org\/10.1155\/2020\/8813558","DOI":"10.1155\/2020\/8813558"},{"key":"2179_CR40","doi-asserted-by":"publisher","DOI":"10.1002\/0471142735.im1401s83","author":"X Zhang","year":"2008","unstructured":"Zhang X, Goncalves R, Mosser DM (2008) The isolation and characterization of murine macrophages. Curr Protoc Immunol 83. https:\/\/doi.org\/10.1002\/0471142735.im1401s83","journal-title":"Curr Protoc Immunol"},{"key":"2179_CR41","doi-asserted-by":"publisher","first-page":"286","DOI":"10.1159\/000529879","volume":"108","author":"L Zhu","year":"2023","unstructured":"Zhu L, Guo J, Liu Q et al (2023) Lafutidine ameliorates indomethacin-induced small intestinal damage in rats by modifying the intestinal mucosal barrier, inflammation, and microbiota. Pharmacology 108:286\u2013300. https:\/\/doi.org\/10.1159\/000529879","journal-title":"Pharmacology"}],"container-title":["Inflammopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10787-026-02179-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10787-026-02179-5","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10787-026-02179-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T05:08:04Z","timestamp":1776316084000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10787-026-02179-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,9]]},"references-count":41,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026,4]]}},"alternative-id":["2179"],"URL":"https:\/\/doi.org\/10.1007\/s10787-026-02179-5","relation":{},"ISSN":["0925-4692","1568-5608"],"issn-type":[{"value":"0925-4692","type":"print"},{"value":"1568-5608","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3,9]]},"assertion":[{"value":"15 November 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 February 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 March 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}