{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T16:18:10Z","timestamp":1778861890844,"version":"3.51.4"},"reference-count":87,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T00:00:00Z","timestamp":1774569600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T00:00:00Z","timestamp":1774569600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Inflammopharmacol"],"published-print":{"date-parts":[[2026,5]]},"DOI":"10.1007\/s10787-026-02207-4","type":"journal-article","created":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T00:10:09Z","timestamp":1774570209000},"page":"3387-3412","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Multi-target modulation of inflammatory pathways by Colchicum luteum in rheumatoid arthritis through experimental and in silico evidence"],"prefix":"10.1007","volume":"34","author":[{"given":"Iqra","family":"Farzeen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Salma","family":"Sultana","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sana","family":"Inam","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Asma","family":"Ashraf","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2026,3,27]]},"reference":[{"issue":"23","key":"2207_CR1","doi-asserted-by":"publisher","first-page":"4020","DOI":"10.3390\/nu16234020","volume":"16","author":"H Abbasi","year":"2024","unstructured":"Abbasi H, Sharif M, John P, Bhatti A, Hayat MQ, Mansoor Q (2024) Phytochemical, cytoprotective profiling, and anti-inflammatory potential of Colchicum luteum in rheumatoid arthritis: an experimental and simulation study. Nutrients 16(23):4020","journal-title":"Nutrients"},{"key":"2207_CR2","doi-asserted-by":"crossref","unstructured":"Abbott NJ (2022) Anatomy and physiology of the blood-brain barriers. In: Drug delivery to the brain: physiological concepts, methodologies and approaches. Springer, pp 3\u201325","DOI":"10.1007\/978-3-030-88773-5_1"},{"key":"2207_CR3","doi-asserted-by":"publisher","first-page":"1050453","DOI":"10.3389\/fphar.2022.1050453","volume":"13","author":"F Abdulhafiz","year":"2022","unstructured":"Abdulhafiz F, Reduan MFH, Hisam AH, Mohammad I, Wahab A, Hamid IRA, Mohammed FF, Nordin A, Shaari ML, R., Bakar LA (2022) LC\u2013TOF-MS\/MS and GC-MS based phytochemical profiling and evaluation of wound healing activity of Oroxylum Indicum (L.) Kurz (Beka). Front Pharmacol 13:1050453","journal-title":"Front Pharmacol"},{"issue":"4","key":"2207_CR4","doi-asserted-by":"publisher","first-page":"276","DOI":"10.4103\/japtr.japtr_440_22","volume":"13","author":"ZH Abdulhusain","year":"2022","unstructured":"Abdulhusain ZH, Mahdi MA, Abdulsahib WK, Jasim LS (2022) Anabasis articulata exerts an anti-arthritic effect on adjuvant-induced arthritis in rats. J Adv Pharm Tech Res 13(4):276\u2013280","journal-title":"J Adv Pharm Tech Res"},{"issue":"1","key":"2207_CR5","first-page":"696","volume":"11","author":"P Aghamohamad Zade","year":"2024","unstructured":"Aghamohamad Zade P, Bahrami S, Mohtashami R, Raei M, Gouvarchinghaleh E, H (2024) An overview of selected medicinal plants for reducing the clinical symptoms of rheumatoid arthritis. Int J Med Reviews 11(1):696\u2013703","journal-title":"Int J Med Reviews"},{"issue":"5","key":"2207_CR6","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1007\/s12032-023-01996-w","volume":"40","author":"S Agrawal","year":"2023","unstructured":"Agrawal S, Das R, Singh AK, Kumar P, Shukla PK, Bhattacharya I, Tripathi AK, Mishra SK, Tiwari KN (2023) Network pharmacology-based anti-pancreatic cancer potential of kaempferol and catechin of Trema orientalis L. through computational approach. Med Oncol 40(5):133","journal-title":"Med Oncol"},{"issue":"10","key":"2207_CR7","doi-asserted-by":"publisher","first-page":"230","DOI":"10.3390\/diseases12100230","volume":"12","author":"T Ahmad","year":"2024","unstructured":"Ahmad T, Kadam P, Bhiyani G, Ali H, Akbar M, Siddique MUM, Shahid M (2024) Artemisia pallens W. Attenuates inflammation and oxidative stress in Freund\u2019s complete adjuvant-induced rheumatoid arthritis in wistar rats. Diseases 12(10):230","journal-title":"Diseases"},{"key":"2207_CR8","doi-asserted-by":"publisher","first-page":"111864","DOI":"10.1016\/j.jep.2019.111864","volume":"238","author":"G Akhtar","year":"2019","unstructured":"Akhtar G, Shabbir A (2019) Urginea indica attenuated rheumatoid arthritis and inflammatory paw edema in diverse animal models of acute and chronic inflammation. J Ethnopharmacol 238:111864","journal-title":"J Ethnopharmacol"},{"issue":"8","key":"2207_CR9","doi-asserted-by":"publisher","first-page":"597","DOI":"10.1016\/j.it.2024.06.005","volume":"45","author":"DE Akinyemi","year":"2024","unstructured":"Akinyemi DE, Chevre R, Soehnlein O (2024) Neuro-immune crosstalk in hematopoiesis, inflammation, and repair. Trends Immunol 45(8):597\u2013608","journal-title":"Trends Immunol"},{"issue":"5","key":"2207_CR10","doi-asserted-by":"publisher","first-page":"863","DOI":"10.1007\/s00296-020-04731-0","volume":"41","author":"K Almutairi","year":"2021","unstructured":"Almutairi K, Nossent J, Preen D, Keen H, Inderjeeth C (2021) The global prevalence of rheumatoid arthritis: a meta-analysis based on a systematic review. Rheumatol Int 41(5):863\u2013877","journal-title":"Rheumatol Int"},{"issue":"1","key":"2207_CR11","doi-asserted-by":"publisher","first-page":"87","DOI":"10.3390\/plants12010087","volume":"12","author":"SH Aly","year":"2022","unstructured":"Aly SH, El-Hassab MA, Elhady SS, Gad HA (2022) Comparative metabolic study of Tamarindus indica L.\u2019s various organs based on GC\/MS analysis, in silico and in vitro anti-inflammatory and wound healing activities. Plants 12(1):87","journal-title":"Plants"},{"issue":"11","key":"2207_CR12","doi-asserted-by":"publisher","first-page":"5931","DOI":"10.3390\/ijms22115931","volume":"22","author":"M Arnittali","year":"2021","unstructured":"Arnittali M, Rissanou AN, Amprazi M, Kokkinidis M, Harmandaris V (2021) Structure and thermal stability of wtRop and RM6 proteins through all-atom molecular dynamics simulations and experiments. Int J Mol Sci 22(11):5931","journal-title":"Int J Mol Sci"},{"key":"2207_CR13","doi-asserted-by":"publisher","first-page":"131392","DOI":"10.1016\/j.foodchem.2021.131392","volume":"373","author":"VK Bajpai","year":"2022","unstructured":"Bajpai VK, Bahuguna A, Kumar V, Khan I, Alrokayan SH, Khan HA, Simal-Gandara J, Xiao J, Na M, Sonwal S (2022) Cellular antioxidant potential and inhibition of foodborne pathogens by a sesquiterpene ilimaquinone in cold storaged ground chicken and under temperature-abuse condition. Food Chem 373:131392","journal-title":"Food Chem"},{"issue":"1","key":"2207_CR14","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1093\/nar\/28.1.235","volume":"28","author":"HM Berman","year":"2000","unstructured":"Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE (2000) The protein data bank. Nucleic Acids Res 28(1):235\u2013242","journal-title":"Nucleic Acids Res"},{"issue":"6","key":"2207_CR15","doi-asserted-by":"publisher","first-page":"4188","DOI":"10.1039\/D3RA06297J","volume":"14","author":"K Bhattacharya","year":"2024","unstructured":"Bhattacharya K, Nath BC, Ahmed E, Khanal P, Chanu NR, Deka S, Das D, Shrivastava AK (2024) Integration of network pharmacology, molecular docking, and simulations to evaluate phytochemicals from Drymaria cordata against cervical cancer. RSC Adv 14(6):4188\u20134200","journal-title":"RSC Adv"},{"issue":"2","key":"2207_CR16","doi-asserted-by":"publisher","first-page":"459","DOI":"10.1021\/ct900549r","volume":"6","author":"P Bjelkmar","year":"2010","unstructured":"Bjelkmar P, Larsson P, Cuendet MA, Hess B, Lindahl E (2010) Implementation of the CHARMM force field in GROMACS: analysis of protein stability effects from correction maps, virtual interaction sites, and water models. J Chem Theory Comput 6(2):459\u2013466","journal-title":"J Chem Theory Comput"},{"key":"2207_CR17","doi-asserted-by":"publisher","first-page":"117498","DOI":"10.1016\/j.jep.2023.117498","volume":"321","author":"R Chalotra","year":"2024","unstructured":"Chalotra R, Dhanawat M, Chauhan S, Mujwar S, Gupta S (2024) Evaluation of Iris Kashmiriana Baker plant extracts against nociception and rheumatoid arthritis in experimental rats: a concept proof by In-silico model. J Ethnopharmacol 321:117498","journal-title":"J Ethnopharmacol"},{"issue":"2","key":"2207_CR18","doi-asserted-by":"publisher","first-page":"240","DOI":"10.1111\/jcpt.13060","volume":"45","author":"L Chen","year":"2020","unstructured":"Chen L, Qu H, Guo M, Zhang Y, Cui Y, Yang Q, Bai R, Shi D (2020) ANRIL and atherosclerosis. J Clin Pharm Ther 45(2):240\u2013248","journal-title":"J Clin Pharm Ther"},{"issue":"Suppl 1","key":"2207_CR19","doi-asserted-by":"publisher","first-page":"S34","DOI":"10.1186\/1471-2105-12-S1-S34","volume":"12","author":"I Chikalov","year":"2011","unstructured":"Chikalov I, Yao P, Moshkov M, Latombe J-C (2011) Learning probabilistic models of hydrogen bond stability from molecular dynamics simulation trajectories. BMC Bioinformatics 12(Suppl 1):S34","journal-title":"BMC Bioinformatics"},{"key":"2207_CR20","unstructured":"Costa D (2022) Characterising the role of inflammatory lipids in regulating systemic inflammation in arthritis, Cardiff University"},{"issue":"18","key":"2207_CR21","doi-asserted-by":"publisher","first-page":"2891","DOI":"10.3390\/diagnostics13182891","volume":"13","author":"Z Cvetkovi\u0107","year":"2023","unstructured":"Cvetkovi\u0107 Z, Panti\u0107 N, Cvetkovi\u0107 M, Virijevi\u0107 M, Sablji\u0107 N, Marinkovi\u0107 G, Milosavljevi\u0107 V, Pravdi\u0107 Z, Suvajd\u017ei\u0107-Vukovi\u0107 N, Mitrovi\u0107 M (2023) The role of the spleen and the place of splenectomy in autoimmune hemolytic anemia\u2014a review of current knowledge. Diagnostics 13(18):2891","journal-title":"Diagnostics"},{"issue":"1","key":"2207_CR22","doi-asserted-by":"publisher","first-page":"42717","DOI":"10.1038\/srep42717","volume":"7","author":"A Daina","year":"2017","unstructured":"Daina A, Michielin O, Zoete V (2017) SwissADME: a free web tool to evaluate pharmacokinetics, drug-likeness and medicinal chemistry friendliness of small molecules. Sci Rep 7(1):42717","journal-title":"Sci Rep"},{"key":"2207_CR23","doi-asserted-by":"crossref","unstructured":"Dallakyan S, Olson AJ (2015) Small-molecule library screening by docking with PyRx. In: Chemical biology: methods and protocols, pp 243\u2013250","DOI":"10.1007\/978-1-4939-2269-7_19"},{"key":"2207_CR24","doi-asserted-by":"publisher","first-page":"117991","DOI":"10.1016\/j.jep.2024.117991","volume":"328","author":"C Das","year":"2024","unstructured":"Das C, Ghosh G, Rath G, Das D, Kar B, Pradhan D, Rai VK, Rajwar TK, Halder J, Dash P (2024) Chemometric profiling and anti-arthritic activity of aerial parts of Glinus oppositifolius (L.) Aug. DC. J Ethnopharmacol 328:117991","journal-title":"J Ethnopharmacol"},{"issue":"21","key":"2207_CR25","doi-asserted-by":"publisher","first-page":"3867","DOI":"10.1021\/jm000292e","volume":"43","author":"WJ Egan","year":"2000","unstructured":"Egan WJ, Merz KM, Baldwin JJ (2000) Prediction of drug absorption using multivariate statistics. J Med Chem 43(21):3867\u20133877","journal-title":"J Med Chem"},{"issue":"1","key":"2207_CR26","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1186\/s13065-023-01011-3","volume":"17","author":"SA Ejaz","year":"2023","unstructured":"Ejaz SA, Farid A, Zargar S, Channar PA, Aziz M, Wani TA, Attaullah HM, Ujhan R, Tehzeeb A, Saeed A (2023) Computational and theoretical chemistry of newly synthesized and characterized 2, 2\u2019-(5, 5\u2019-(1, 4-phenylene) bis (1 H-tetrazole-5, 1-diyl)) bis-N-acetamides. BMC Chem 17(1):97","journal-title":"BMC Chem"},{"issue":"1","key":"2207_CR27","doi-asserted-by":"publisher","first-page":"155932582110697","DOI":"10.1177\/15593258211069720","volume":"20","author":"S Farooq","year":"2022","unstructured":"Farooq S, Shaheen G, Asif HM, Aslam MR, Zahid R, Rajpoot SR, Jabbar S, Zafar F (2022) Preliminary phytochemical analysis: in-vitro comparative evaluation of anti-arthritic and anti-inflammatory potential of some traditionally used medicinal plants. Dose-Response 20(1):15593258211069720","journal-title":"Dose-Response"},{"key":"2207_CR28","doi-asserted-by":"publisher","first-page":"103214","DOI":"10.1016\/j.jaut.2024.103214","volume":"146","author":"Q Geng","year":"2024","unstructured":"Geng Q, Xu J, Cao X, Wang Z, Jiao Y, Diao W, Wang X, Wang Z, Zhang M, Zhao L (2024) PPARG-mediated autophagy activation alleviates inflammation in rheumatoid arthritis. J Autoimmun 146:103214","journal-title":"J Autoimmun"},{"issue":"1","key":"2207_CR29","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1021\/cc9800071","volume":"1","author":"AK Ghose","year":"1999","unstructured":"Ghose AK, Viswanadhan VN, Wendoloski JJ (1999) A knowledge-based approach in designing combinatorial or medicinal chemistry libraries for drug discovery. 1. A qualitative and quantitative characterization of known drug databases. J Comb Chem 1(1):55\u201368","journal-title":"J Comb Chem"},{"issue":"6","key":"2207_CR30","doi-asserted-by":"publisher","first-page":"3281","DOI":"10.1007\/s10787-023-01357-z","volume":"31","author":"B Gul","year":"2023","unstructured":"Gul B, Anwar R, Saleem M, Ahmad M, Ullah MI, Kamran S (2023) Attenuation of CFA-induced arthritis through regulation of inflammatory cytokines and antioxidant mechanisms by Solanum nigrum L. leaves extracts. Inflammopharmacology 31(6):3281\u20133301","journal-title":"Inflammopharmacology"},{"issue":"4","key":"2207_CR31","doi-asserted-by":"publisher","first-page":"354","DOI":"10.15537\/smj.2016.4.14768","volume":"37","author":"G Harifi","year":"2016","unstructured":"Harifi G, Sibilia J (2016) Pathogenic role of platelets in rheumatoid arthritis and systemic autoimmune diseases: perspectives and therapeutic aspects. Saudi Med J 37(4):354","journal-title":"Saudi Med J"},{"key":"2207_CR32","doi-asserted-by":"crossref","unstructured":"Hidayat AFA, Mohamad SB (2025) Incorporating target protein structure flexibility and dynamics in computational drug discovery using ensemble-based docking analysis. J Vis Exp (JoVE) (220), e67174","DOI":"10.3791\/67174"},{"issue":"1","key":"2207_CR33","doi-asserted-by":"publisher","first-page":"44","DOI":"10.26656\/fr.2017.8(1).057","volume":"8","author":"M Hossain","year":"2024","unstructured":"Hossain M, Ahmad N, Alam M, Hossain M, Sarkar A (2024) Screening of different extraction methods for maximum production of total flavonoids, tannins, and antioxidants from Centella asiatica. Food Res 8(1):44\u201351","journal-title":"Food Res"},{"key":"2207_CR34","doi-asserted-by":"publisher","first-page":"114393","DOI":"10.1016\/j.intimp.2025.114393","volume":"152","author":"Y Hou","year":"2025","unstructured":"Hou Y, Yang Z, Ma J, Zhang B, Sun X, Li J, Liu J, Yang Z (2025) Identification of PTPRC as a potential serum biomarker in rheumatoid arthritis using bioinformatics analysis and molecular docking. Int Immunopharmacol 152:114393","journal-title":"Int Immunopharmacol"},{"issue":"1","key":"2207_CR35","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1016\/j.advms.2017.06.004","volume":"63","author":"M Hoxha","year":"2018","unstructured":"Hoxha M (2018) A systematic review on the role of eicosanoid pathways in rheumatoid arthritis. Adv Med Sci 63(1):22\u201329","journal-title":"Adv Med Sci"},{"issue":"19","key":"2207_CR36","doi-asserted-by":"publisher","first-page":"6323","DOI":"10.3390\/molecules27196323","volume":"27","author":"N Iftikhar","year":"2022","unstructured":"Iftikhar N, Saleem A, Akhtar MF, Abbas G, Shah S, Bibi S, Ashraf GM, Alghamdi BS, Abujamel TS (2022) In vitro and in vivo anti-arthritic potential of caralluma tuberculata NE Brown and its chemical characterization. Molecules 27(19):6323","journal-title":"Molecules"},{"key":"2207_CR37","doi-asserted-by":"publisher","first-page":"111347","DOI":"10.1016\/j.biopha.2021.111347","volume":"137","author":"GAA Jaleel","year":"2021","unstructured":"Jaleel GAA, Azab SS, El-Bakly WM, Hassan A (2021) Methyl palmitate attenuates adjuvant induced arthritis in rats by decrease of CD68 synovial macrophages. Biomed Pharmacother 137:111347","journal-title":"Biomed Pharmacother"},{"issue":"4","key":"2207_CR38","doi-asserted-by":"publisher","first-page":"689","DOI":"10.22271\/tpi.2021.v10.i4j.6038","volume":"10","author":"DG Joshi","year":"2021","unstructured":"Joshi DG, Jat RK, Patil SB (2021) In vitro protein denaturation and membrane stabilising anti-arthritic activity of aqueous extracts of bark of Ficus benghalensis L. against methotrexate. Pharma Innov J 10(4):689\u2013692","journal-title":"Pharma Innov J"},{"key":"2207_CR39","doi-asserted-by":"crossref","unstructured":"Juvale IIA, Hamid AAA, Abd Halim KB, Has ATC (2022) P-glycoprotein: new insights into structure, physiological function, regulation and alterations in disease. Heliyon, 8(6)","DOI":"10.1016\/j.heliyon.2022.e09777"},{"key":"2207_CR40","doi-asserted-by":"crossref","unstructured":"Kamau JK, Ngugi MP, Ngeranwa JN (2025) Anti-arthritic potential and mechanistic insights of methanol extract of Rhamnus prinoides Engl. in complete Freund\u2019s adjuvant-induced rats. Inflammopharmacology, 1\u201317","DOI":"10.1007\/s10787-025-01770-6"},{"issue":"4","key":"2207_CR41","first-page":"44","volume":"4","author":"A Kaur","year":"2012","unstructured":"Kaur A, Nain P, Nain J (2012) Herbal plants used in treatment of rheumatoid arthritis: a review. Int J Pharm Pharm Sci 4(4):44\u201357","journal-title":"Int J Pharm Pharm Sci"},{"issue":"3","key":"2207_CR42","doi-asserted-by":"publisher","first-page":"1705","DOI":"10.1007\/s10787-024-01445-8","volume":"32","author":"C Kaur","year":"2024","unstructured":"Kaur C, Mishra Y, Kumar R, Singh G, Singh S, Mishra V, Tambuwala MM (2024) Pathophysiology, diagnosis, and herbal medicine-based therapeutic implication of rheumatoid arthritis: an overview. Inflammopharmacology 32(3):1705\u20131720","journal-title":"Inflammopharmacology"},{"key":"2207_CR43","doi-asserted-by":"publisher","first-page":"114872","DOI":"10.1016\/j.biopha.2023.114872","volume":"164","author":"HA Khan","year":"2023","unstructured":"Khan HA, Ghufran M, Shams S, Jamal A, Ayaz M, Ullah M, Khan A, Khan MI, Awan ZA (2023) In-depth in-vitro and in-vivo anti-diabetic evaluations of Fagonia cretica mediated biosynthesized selenium nanoparticles. Biomed Pharmacother 164:114872","journal-title":"Biomed Pharmacother"},{"issue":"4","key":"2207_CR44","doi-asserted-by":"publisher","first-page":"431","DOI":"10.3390\/ph17040431","volume":"17","author":"G Khawaja","year":"2024","unstructured":"Khawaja G, El-Orfali Y (2024) Silibinin\u2019s effects against methotrexate-induced hepatotoxicity in adjuvant-induced arthritis rat model. Pharmaceuticals 17(4):431","journal-title":"Pharmaceuticals"},{"key":"2207_CR45","doi-asserted-by":"publisher","first-page":"114509","DOI":"10.1016\/j.biopha.2023.114509","volume":"161","author":"DY Kim","year":"2023","unstructured":"Kim DY, Sung J-H (2023) The effects of GPR40 agonists on hair growth are mediated by ANGPTL4. Biomed Pharmacother 161:114509","journal-title":"Biomed Pharmacother"},{"issue":"1\u20133","key":"2207_CR46","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1016\/S0169-409X(96)00423-1","volume":"23","author":"CA Lipinski","year":"1997","unstructured":"Lipinski CA, Lombardo F, Dominy BW, Feeney PJ (1997) Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings. Adv Drug Deliv Rev 23(1\u20133):3\u201325","journal-title":"Adv Drug Deliv Rev"},{"issue":"2","key":"2207_CR47","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1016\/j.pop.2018.02.010","volume":"45","author":"EA Littlejohn","year":"2018","unstructured":"Littlejohn EA, Monrad SU (2018) Early diagnosis and treatment of rheumatoid arthritis. Prim Care: Clin Office Pract 45(2):237\u2013255","journal-title":"Prim Care: Clin Office Pract"},{"key":"2207_CR48","doi-asserted-by":"publisher","first-page":"106570","DOI":"10.1016\/j.intimp.2020.106570","volume":"84","author":"P Liu","year":"2020","unstructured":"Liu P, Wang J, Wen W, Pan T, Chen H, Fu Y, Wang F, Huang JH, Xu S (2020) Cinnamaldehyde suppresses NLRP3 derived IL-1\u03b2 via activating succinate\/HIF-1 in rheumatoid arthritis rats. Int Immunopharmacol 84:106570","journal-title":"Int Immunopharmacol"},{"key":"2207_CR49","first-page":"100255","volume":"18","author":"M Mahajan","year":"2020","unstructured":"Mahajan M, Kuiry R, Pal PK (2020) Understanding the consequence of environmental stress for accumulation of secondary metabolites in medicinal and aromatic plants. J Appl Res Med Aromatic Plants 18:100255","journal-title":"J Appl Res Med Aromatic Plants"},{"issue":"2","key":"2207_CR50","doi-asserted-by":"publisher","first-page":"696","DOI":"10.1080\/07391102.2020.1817787","volume":"40","author":"R Majumder","year":"2022","unstructured":"Majumder R, Mandal M (2022) Screening of plant-based natural compounds as a potential COVID-19 main protease inhibitor: an in silico docking and molecular dynamics simulation approach. J Biomol Struct Dynamics 40(2):696\u2013711","journal-title":"J Biomol Struct Dynamics"},{"issue":"31","key":"2207_CR51","doi-asserted-by":"publisher","first-page":"19478","DOI":"10.1021\/acsomega.0c01670","volume":"5","author":"M Manan","year":"2020","unstructured":"Manan M, Saleem U, Akash MSH, Qasim M, Hayat M, Raza Z, Ahmad B (2020) Antiarthritic potential of comprehensively standardized extract of alternanthera bettzickiana: in vitro and in vivo studies. ACS omega 5(31):19478\u201319496","journal-title":"ACS omega"},{"issue":"9","key":"2207_CR52","doi-asserted-by":"publisher","first-page":"2228","DOI":"10.3390\/pharmaceutics15092228","volume":"15","author":"K Mashaal","year":"2023","unstructured":"Mashaal K, Shabbir A, Khan MA, Hameed H, Shahzad M, Irfan A, Shazly GA, Mobashar A, Akhtar T, Shaheryar ZA (2023) Anti-arthritic and immunomodulatory potential of methanolic, n-hexane, and ethyl acetate fractions of bark of Acacia modesta on complete Freund\u2019s adjuvant-induced arthritis in rats. Pharmaceutics 15(9):2228","journal-title":"Pharmaceutics"},{"issue":"1","key":"2207_CR53","doi-asserted-by":"publisher","first-page":"100123","DOI":"10.1016\/j.ccmp.2023.100123","volume":"4","author":"A Mazumder","year":"2024","unstructured":"Mazumder A, Acharyya RN, Kundu MK, Kundu P, Islam MA, Rahman MM (2024) Phytochemical screening and evaluation of pharmacological potential of Baliospermum solanifolium Leaf Extract. Clin Complement Med Pharmacol 4(1):100123","journal-title":"Clin Complement Med Pharmacol"},{"issue":"5","key":"2207_CR54","doi-asserted-by":"publisher","first-page":"1406","DOI":"10.3390\/jcm13051406","volume":"13","author":"I Minciuna","year":"2024","unstructured":"Minciuna I, Taru MG, Procopet B, Stefanescu H (2024) The interplay between liver sinusoidal endothelial cells, platelets, and neutrophil extracellular traps in the development and progression of metabolic dysfunction-associated steatotic liver disease. J Clin Med 13(5):1406","journal-title":"J Clin Med"},{"issue":"1","key":"2207_CR55","doi-asserted-by":"publisher","first-page":"11315","DOI":"10.1038\/s41598-017-11803-y","volume":"7","author":"RE Mitchell","year":"2017","unstructured":"Mitchell RE, Hassan M, Burton BR, Britton G, Hill EV, Verhagen J, Wraith DC (2017) IL-4 enhances IL-10 production in Th1 cells: implications for Th1 and Th2 regulation. Sci Rep 7(1):11315","journal-title":"Sci Rep"},{"issue":"8","key":"2207_CR56","doi-asserted-by":"publisher","first-page":"1567","DOI":"10.3390\/pr12081567","volume":"12","author":"AAB Mokaizh","year":"2024","unstructured":"Mokaizh AAB, Nour AH, Alazaiza MY, Mustafa SE, Omer MS, Nassani DE (2024) Extraction and characterization of biological phytoconstituents of commiphora gileadensis leaves using soxhlet method. Processes 12(8):1567","journal-title":"Processes"},{"issue":"12","key":"2207_CR57","doi-asserted-by":"publisher","first-page":"1841","DOI":"10.1021\/jm015507e","volume":"44","author":"I Muegge","year":"2001","unstructured":"Muegge I, Heald SL, Brittelli D (2001) Simple selection criteria for drug-like chemical matter. J Med Chem 44(12):1841\u20131846","journal-title":"J Med Chem"},{"issue":"4","key":"2207_CR58","doi-asserted-by":"publisher","first-page":"433","DOI":"10.2174\/1872210517666230822100324","volume":"18","author":"G Nautiyal","year":"2024","unstructured":"Nautiyal G, Sharma SK, Kaushik D, Pandey P (2024) Nano-based therapeutic strategies in management of rheumatoid arthritis. Recent Pat Nanotechnol 18(4):433\u2013456","journal-title":"Recent Pat Nanotechnol"},{"issue":"1","key":"2207_CR59","doi-asserted-by":"publisher","first-page":"825","DOI":"10.1007\/s10787-023-01391-x","volume":"32","author":"N Nazar","year":"2024","unstructured":"Nazar N, Mehmood MH, Siddique R, Faisal MN (2024) Assessment of antiarthritic potential of Asparagus dumosus using formaldehyde and CFA-induced arthritic models in rats via modulation of oxidative stress biomarkers and mRNA expression of IL-1b, IL-6, RANKL, OPG, TNF-\u03b1 and COX-2. Inflammopharmacology 32(1):825\u2013847","journal-title":"Inflammopharmacology"},{"issue":"9","key":"2207_CR60","doi-asserted-by":"publisher","first-page":"739","DOI":"10.2174\/13862073113169990002","volume":"16","author":"PK Ojha","year":"2013","unstructured":"Ojha PK, Roy K (2013) Exploring structural requirements for a class of nucleoside inhibitors (PfdUTPase) as antimalarials: first report on QSAR, pharmacophore mapping and multiple docking studies. Comb Chem High Throughput Screen 16(9):739\u2013757","journal-title":"Comb Chem High Throughput Screen"},{"issue":"1","key":"2207_CR61","doi-asserted-by":"publisher","first-page":"85","DOI":"10.5114\/bta.2021.103765","volume":"102","author":"CJ Ononamadu","year":"2021","unstructured":"Ononamadu CJ, Ibrahim A (2021) Molecular docking and prediction of ADME\/drug-likeness properties of potentially active antidiabetic compounds isolated from aqueous-methanol extracts of Gymnema sylvestre and Combretum micranthum. BioTechnologia 102(1):85","journal-title":"BioTechnologia"},{"issue":"1","key":"2207_CR62","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1186\/s43094-020-00163-6","volume":"7","author":"S Paul","year":"2021","unstructured":"Paul S, Modak D, Chattaraj S, Nandi D, Sarkar A, Roy J, Chaudhuri TK, Bhattacharjee S (2021) Aloe vera gel homogenate shows anti-inflammatory activity through lysosomal membrane stabilization and downregulation of TNF-\u03b1 and Cox-2 gene expressions in inflammatory arthritic animals. Future J Pharm Sci 7(1):12","journal-title":"Future J Pharm Sci"},{"issue":"1","key":"2207_CR63","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1002\/pro.3943","volume":"30","author":"EF Pettersen","year":"2021","unstructured":"Pettersen EF, Goddard TD, Huang CC, Meng EC, Couch GS, Croll TI, Morris JH, Ferrin TE (2021) UCSF ChimeraX: structure visualization for researchers, educators, and developers. Protein Sci 30(1):70\u201382","journal-title":"Protein Sci"},{"issue":"3","key":"2207_CR64","doi-asserted-by":"publisher","first-page":"2379","DOI":"10.1021\/acsomega.0c05698","volume":"6","author":"S Qasim","year":"2021","unstructured":"Qasim S, Alamgeer, Saleem M, Alotaibi NH, Bukhari SNA, Alharbi KS, Irfan HM, Anwar R (2021) Appraisal of the antiarthritic potential of prazosin via inhibition of proinflammatory cytokine TNF-\u03b1: a key player in rheumatoid arthritis. ACS Omega 6(3):2379\u20132388","journal-title":"ACS omega"},{"issue":"11","key":"2207_CR65","doi-asserted-by":"publisher","first-page":"2857","DOI":"10.3390\/cells10112857","volume":"10","author":"A-F Radu","year":"2021","unstructured":"Radu A-F, Bungau SG (2021) Management of rheumatoid arthritis: an overview. Cells 10(11):2857","journal-title":"Cells"},{"key":"2207_CR66","doi-asserted-by":"publisher","first-page":"689698","DOI":"10.3389\/fmed.2021.689698","volume":"8","author":"VC Rom\u00e3o","year":"2021","unstructured":"Rom\u00e3o VC, Fonseca JE (2021) Etiology and risk factors for rheumatoid arthritis: a state-of-the-art review. Front Med 8:689698","journal-title":"Front Med"},{"key":"2207_CR67","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1007\/s10787-019-00596-3","volume":"28","author":"A Saleem","year":"2020","unstructured":"Saleem A, Saleem M, Akhtar MF, Shahzad M, Jahan S (2020) Moringa rivae leaf extracts attenuate Complete Freund\u2019s adjuvant-induced arthritis in Wistar rats via modulation of inflammatory and oxidative stress biomarkers. Inflammopharmacology 28:139\u2013151","journal-title":"Inflammopharmacology"},{"key":"2207_CR68","doi-asserted-by":"crossref","unstructured":"Shah RK (2024) In silico docking, ADME\/drug likeness and molecular dynamics simulation analysis of few phytoconstituents to identify potential inhibitor of PBP 4 of Staphylococcus aureus. In: Proceedings of the Indian National Science Academy, 1\u201312","DOI":"10.1007\/s43538-024-00354-2"},{"issue":"16","key":"2207_CR69","doi-asserted-by":"publisher","first-page":"6125","DOI":"10.3390\/molecules28166125","volume":"28","author":"A Sharma","year":"2023","unstructured":"Sharma A, Goel A, Lin Z (2023) In vitro and in silico anti-rheumatic arthritis activity of nyctanthes arbor-tristis. Molecules 28(16):6125","journal-title":"Molecules"},{"issue":"7","key":"2207_CR70","doi-asserted-by":"publisher","first-page":"593","DOI":"10.1080\/17425255.2024.2365254","volume":"20","author":"YC Shin","year":"2024","unstructured":"Shin YC, Than N, Park SJ, Kim HJ (2024) Bioengineered human gut-on-a-chip for advancing non-clinical pharmaco-toxicology. Expert Opin Drug Metab Toxicol 20(7):593\u2013606","journal-title":"Expert Opin Drug Metab Toxicol"},{"issue":"4","key":"2207_CR71","doi-asserted-by":"publisher","first-page":"2445","DOI":"10.1007\/s10787-024-01512-0","volume":"32","author":"NT Sial","year":"2024","unstructured":"Sial NT, Malik A, Iqbal U, Mehmood MH, Rehman MFu (2024a) Novel antiarthritic mechanisms of azelaic acid against CFA-induced arthritis in rats by modulating pro-and anti-inflammatory cytokines network. Inflammopharmacology 32(4):2445\u20132462","journal-title":"Inflammopharmacology"},{"issue":"4","key":"2207_CR72","doi-asserted-by":"publisher","first-page":"2377","DOI":"10.1007\/s10787-024-01480-5","volume":"32","author":"NT Sial","year":"2024","unstructured":"Sial NT, Malik A, Iqbal U, Rehman MFU (2024b) Arbutin attenuates CFA-induced arthritis by modulating expression levels of 5-LOX, NF\u2013\u03baB, IL-17, PGE-2 and TNF-\u03b1. Inflammopharmacology 32(4):2377\u20132394","journal-title":"Inflammopharmacology"},{"issue":"5","key":"2207_CR73","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s10787-024-01537-5","volume":"32","author":"R Siddique","year":"2024","unstructured":"Siddique R, Muhammad F, Faisal MN, Akhtar B, Saleem A, Kousar S, Sharif A, Saeed M, Muhammad S (2024) Gingerol nanoparticles attenuate complete Freund adjuvant-induced arthritis in rats via targeting the RANKL\/OPG signaling pathway. Inflammopharmacology 32(5):1\u201316","journal-title":"Inflammopharmacology"},{"key":"2207_CR74","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s13020-020-00401-2","volume":"15","author":"Y Song","year":"2020","unstructured":"Song Y, Yang J, Jing W, Wang Q, Liu Y, Cheng X, Ye F, Tian J, Wei F, Ma S (2020) Systemic elucidation on the potential bioactive compounds and hypoglycemic mechanism of Polygonum multiflorum based on network pharmacology. Chin Med 15:1\u201315","journal-title":"Chin Med"},{"key":"2207_CR75","unstructured":"Tong W, HE L (2023) Effect of Shikonin on Synovitis in Mice with Collagen-induced Arthritis through MAPK1\/MAPK Pathway. Chin J Exp Tradit Med Formulae, 56\u201363"},{"key":"2207_CR76","doi-asserted-by":"publisher","first-page":"111536","DOI":"10.1016\/j.envres.2021.111536","volume":"201","author":"D Varaden","year":"2021","unstructured":"Varaden D, Leidland E, Lim S, Barratt B (2021) I am an air quality scientist\u2013using citizen science to characterise school children\u2019s exposure to air pollution. Environ Res 201:111536","journal-title":"Environ Res"},{"issue":"12","key":"2207_CR77","doi-asserted-by":"publisher","first-page":"2615","DOI":"10.1021\/jm020017n","volume":"45","author":"DF Veber","year":"2002","unstructured":"Veber DF, Johnson SR, Cheng H-Y, Smith BR, Ward KW, Kopple KD (2002) Molecular properties that influence the oral bioavailability of drug candidates. J Med Chem 45(12):2615\u20132623","journal-title":"J Med Chem"},{"issue":"12","key":"2207_CR78","doi-asserted-by":"publisher","first-page":"e14298","DOI":"10.1111\/eci.14298","volume":"54","author":"NI Vlachogiannis","year":"2024","unstructured":"Vlachogiannis NI, Verrou KM, Yavropoulou MP, Tektonidou M, Chrousos GP, Sfikakis PP (2024) Synovial expression of glucocorticoid receptor parallels fibroblast activation in patients with rheumatoid arthritis. Eur J Clin Invest 54(12):e14298","journal-title":"Eur J Clin Invest"},{"issue":"1","key":"2207_CR79","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1186\/s13020-024-00910-4","volume":"19","author":"W Wang","year":"2024","unstructured":"Wang W, Zhang Z-Q, Zhang Y-C, Wu Y-Q, Yang Z, Zheng Y-Z, Lu J-H, Tu P-F, Zeng K-W (2024) Cayratia albifolia CL Li exerts anti-rheumatoid arthritis effect by inhibiting macrophage activation and neutrophil extracellular traps (NETs). Chin Med 19(1):42","journal-title":"Chin Med"},{"issue":"1","key":"2207_CR80","doi-asserted-by":"publisher","first-page":"BSR20191136","DOI":"10.1042\/BSR20191136","volume":"40","author":"Q Wei","year":"2020","unstructured":"Wei Q, Lv F, Zhang H, Wang X, Geng Q, Zhang X, Li T, Wang S, Wang Y, Cui Y (2020) MicroRNA-101-3p inhibits fibroblast-like synoviocyte proliferation and inflammation in rheumatoid arthritis by targeting PTGS2. Biosci Rep 40(1):BSR20191136","journal-title":"Biosci Rep"},{"key":"2207_CR81","doi-asserted-by":"publisher","first-page":"693701","DOI":"10.3389\/fphar.2021.693701","volume":"12","author":"X Wei","year":"2021","unstructured":"Wei X, Hou W, Liang J, Fang P, Dou B, Wang Z, Sai J, Xu T, Ma C, Zhang Q (2021) Network pharmacology-based analysis on the potential biological mechanisms of sinisan against non-alcoholic fatty liver disease. Front Pharmacol 12:693701","journal-title":"Front Pharmacol"},{"key":"2207_CR82","doi-asserted-by":"crossref","unstructured":"Widyowati R, Pratama RR, Sholikhah I, Jain SK (2024) Herbal medicine and rheumatic disorders management and prevention. In: Herbal medicine phytochemistry: applications and trends. Springer, pp 723\u2013762","DOI":"10.1007\/978-3-031-43199-9_26"},{"key":"2207_CR83","doi-asserted-by":"publisher","first-page":"116852","DOI":"10.1016\/j.jep.2023.116852","volume":"317","author":"B Xiao","year":"2023","unstructured":"Xiao B, Li J, Qiao Z, Yang S, Kwan H-Y, Jiang T, Zhang M, Xia Q, Liu Z, Su T (2023) Therapeutic effects of Siegesbeckia orientalis L. And its active compound luteolin in rheumatoid arthritis: network pharmacology, molecular docking and experimental validation. J Ethnopharmacol 317:116852","journal-title":"J Ethnopharmacol"},{"key":"2207_CR84","doi-asserted-by":"publisher","first-page":"104496","DOI":"10.1016\/j.fbio.2024.104496","volume":"60","author":"S Yagi","year":"2024","unstructured":"Yagi S, Zengin G, Eldahshan OA, Singab ANB, Selvi S, Cetiz MV, Rodrigues MJ, Custodio L, Dall\u2019Acqua S, Elhawary EA (2024) Functional constituents of Colchicum lingulatum Boiss. & Spruner subsp. Rigescens K. Perss. extracts and their biological activities with different perspectives. Food Bioscience 60:104496","journal-title":"Food Biosci"},{"key":"2207_CR85","unstructured":"Yu M (2012) Computational modeling of protein dynamics with GROMACS and Java"},{"key":"2207_CR86","doi-asserted-by":"publisher","first-page":"109451","DOI":"10.1016\/j.cbi.2021.109451","volume":"341","author":"C Zhang","year":"2021","unstructured":"Zhang C, Ma K, Yang Y, Wang F, Li W (2021) Glaucocalyxin A suppresses inflammatory responses and induces apoptosis in TNF-a-induced human rheumatoid arthritis via modulation of the STAT3 pathway. Chemico-Biol Interact 341:109451","journal-title":"Chemico-Biol Interact"},{"issue":"4","key":"2207_CR87","doi-asserted-by":"publisher","first-page":"e202302387","DOI":"10.1002\/slct.202302387","volume":"9","author":"Z Zhao","year":"2024","unstructured":"Zhao Z, Song J, Shang Y, Shan M, Tang L, Pang T, Ye Q, Cheng G, Jiang G (2024) Design, synthesis, biological evaluation and docking study of a new series of 9-aminoacridine derivatives as anti\u2010inflammatory agents. ChemistrySelect 9(4):e202302387","journal-title":"ChemistrySelect"}],"container-title":["Inflammopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10787-026-02207-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10787-026-02207-4","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10787-026-02207-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T16:04:24Z","timestamp":1778861064000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10787-026-02207-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,27]]},"references-count":87,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026,5]]}},"alternative-id":["2207"],"URL":"https:\/\/doi.org\/10.1007\/s10787-026-02207-4","relation":{},"ISSN":["0925-4692","1568-5608"],"issn-type":[{"value":"0925-4692","type":"print"},{"value":"1568-5608","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3,27]]},"assertion":[{"value":"17 February 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 March 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 March 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"This research received necessary authorization from Animal Ethical Committee (AEC), Faculty of Zoology, GCUF. The Institutional Animal Ethics Committee authorized the animal experiments GCUF\/ERC\/\/665.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}}]}}