{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,18]],"date-time":"2026-07-18T06:01:57Z","timestamp":1784354517473,"version":"3.55.0"},"reference-count":56,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T00:00:00Z","timestamp":1779235200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T00:00:00Z","timestamp":1779235200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"name":"Ministry of Science and Technology, Taiwan","award":["MOST 111-2314-B-303 -007 -MY3"],"award-info":[{"award-number":["MOST 111-2314-B-303 -007 -MY3"]}]},{"DOI":"10.13039\/501100012542","name":"Dalin Tzu Chi Hospital","doi-asserted-by":"publisher","award":["DTCRD113-I-01-01"],"award-info":[{"award-number":["DTCRD113-I-01-01"]}],"id":[{"id":"10.13039\/501100012542","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100020595","name":"National Science and Technology Council","doi-asserted-by":"publisher","award":["NSTC 114-2314-B-303 -024 -MY3"],"award-info":[{"award-number":["NSTC 114-2314-B-303 -024 -MY3"]}],"id":[{"id":"10.13039\/100020595","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Inflammopharmacol"],"published-print":{"date-parts":[[2026,6]]},"DOI":"10.1007\/s10787-026-02262-x","type":"journal-article","created":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T11:24:21Z","timestamp":1779276261000},"page":"4239-4252","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Inhibiting pyruvate carboxylase as a potential therapeutic strategy for alleviating rheumatoid arthritis"],"prefix":"10.1007","volume":"34","author":[{"given":"Szu-Wei","family":"Huang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui-Chun","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hsien-Bin","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pin-Chen","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming-Chi","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,5,20]]},"reference":[{"issue":"9","key":"2262_CR1","doi-asserted-by":"publisher","first-page":"1782","DOI":"10.1161\/ATVBAHA.116.307830","volume":"36","author":"A Aarup","year":"2016","unstructured":"Aarup A, Pedersen TX, Junker N, Christoffersen C, Bartels ED, Madsen M, Nielsen CH, Nielsen LB (2016) Hypoxia-Inducible Factor-1alpha Expression in Macrophages Promotes Development of Atherosclerosis. Arterioscler Thromb Vasc Biol 36(9):1782\u20131790","journal-title":"Arterioscler Thromb Vasc Biol"},{"issue":"3","key":"2262_CR2","doi-asserted-by":"publisher","first-page":"603","DOI":"10.1002\/jcsm.12280","volume":"9","author":"PVG Alabarse","year":"2018","unstructured":"Alabarse PVG, Lora PS, Silva JMS, Santo RCE, Freitas EC, de Oliveira MS, Almeida AS, Immig M, Teixeira VON, Filippin LI, Xavier RM (2018) Collagen-induced arthritis as an animal model of rheumatoid cachexia. J Cachexia Sarcopenia Muscle 9(3):603\u2013612","journal-title":"J Cachexia Sarcopenia Muscle"},{"issue":"5","key":"2262_CR3","doi-asserted-by":"publisher","first-page":"1495","DOI":"10.3892\/ijmm.2017.3143","volume":"40","author":"H Bian","year":"2017","unstructured":"Bian H, Li F, Wang W, Zhao Q, Gao S, Ma J, Li X, Ren W, Qin C, Qi J (2017) MAPK\/p38 regulation of cytoskeleton rearrangement accelerates induction of macrophage activation by TLR4, but not TLR3. Int J Mol Med 40(5):1495\u20131503","journal-title":"Int J Mol Med"},{"key":"2262_CR4","doi-asserted-by":"publisher","first-page":"1590797","DOI":"10.3389\/fphar.2025.1590797","volume":"16","author":"Y Bu","year":"2025","unstructured":"Bu Y, Li Z, Wang C, Yu Y, Liu C, Sun Y, Sun Z, Gong W, Luo J, Yue Z (2025) Anemoside B4 targets RAGE to attenuate ferroptosis in sepsis-induced acute lung injury. Front Pharmacol 16:1590797","journal-title":"Front Pharmacol"},{"issue":"6","key":"2262_CR5","doi-asserted-by":"publisher","first-page":"1291","DOI":"10.1016\/j.cmet.2019.03.014","volume":"29","author":"DA Cappel","year":"2019","unstructured":"Cappel DA, Deja S, Duarte JAG, Kucejova B, I\u00f1igo M, Fletcher JA, Fu X, Berglund ED, Liu T, Elmquist JK, Hammer S, Mishra P, Browning JD, Burgess SC (2019) Pyruvate-Carboxylase-Mediated Anaplerosis Promotes Antioxidant Capacity by Sustaining TCA Cycle and Redox Metabolism in Liver. Cell Metab 29(6):1291\u20131305e8","journal-title":"Cell Metab"},{"issue":"10","key":"2262_CR6","doi-asserted-by":"publisher","first-page":"1317","DOI":"10.1038\/ncb3233","volume":"17","author":"S Cardaci","year":"2015","unstructured":"Cardaci S, Zheng L, MacKay G, van den Broek NJ, MacKenzie ED, Nixon C, Stevenson D, Tumanov S, Bulusu V, Kamphorst JJ, Vazquez A, Fleming S, Schiavi F, Kalna G, Blyth K, Strathdee D, Gottlieb E (2015) Pyruvate carboxylation enables growth of SDH-deficient cells by supporting aspartate biosynthesis. Nat Cell Biol 17(10):1317\u20131326","journal-title":"Nat Cell Biol"},{"key":"2262_CR7","doi-asserted-by":"publisher","first-page":"1179973","DOI":"10.1155\/2023\/1179973","volume":"2023","author":"J Chen","year":"2023","unstructured":"Chen J, Sun N, Li F, Li H, Tian J, Zheng S, Zhang L, Wang H, Luo Y (2023) Carnosol Alleviates Collagen-Induced Arthritis by Inhibiting Th17-Mediated Immunity and Favoring Suppressive Activity of Regulatory T Cells. Biomed Res Int 2023:1179973","journal-title":"Biomed Res Int"},{"issue":"3","key":"2262_CR8","doi-asserted-by":"publisher","first-page":"678","DOI":"10.1002\/art.23284","volume":"58","author":"C Clavel","year":"2008","unstructured":"Clavel C, Nogueira L, Laurent L, Iobagiu C, Vincent C, Sebbag M, Serre G (2008) Induction of macrophage secretion of tumor necrosis factor alpha through Fcgamma receptor IIa engagement by rheumatoid arthritis-specific autoantibodies to citrullinated proteins complexed with fibrinogen. Arthritis Rheum 58(3):678\u2013688","journal-title":"Arthritis Rheum"},{"issue":"10","key":"2262_CR9","doi-asserted-by":"publisher","first-page":"e594","DOI":"10.1016\/S2665-9913(23)00211-4","volume":"5","author":"GBDRA Collaborators","year":"2023","unstructured":"Collaborators GBDRA (2023) Global, regional, and national burden of rheumatoid arthritis, 1990\u20132020, and projections to 2050: a systematic analysis of the Global Burden of Disease Study 2021. Lancet Rheumatol 5(10):e594\u2013e610","journal-title":"Lancet Rheumatol"},{"issue":"11","key":"2262_CR10","doi-asserted-by":"publisher","first-page":"12214","DOI":"10.3390\/cimb46110725","volume":"46","author":"J Cui","year":"2024","unstructured":"Cui J, Chai S, Liu R, Shen G (2024) Targeting PGK1: A New Frontier in Breast Cancer Therapy Under Hypoxic Conditions. Curr Issues Mol Biol 46(11):12214\u201312229","journal-title":"Curr Issues Mol Biol"},{"issue":"10416","key":"2262_CR11","doi-asserted-by":"publisher","first-page":"2019","DOI":"10.1016\/S0140-6736(23)01525-8","volume":"402","author":"A Di Matteo","year":"2023","unstructured":"Di Matteo A, Bathon JM, Emery P (2023) Rheumatoid arthritis. Lancet 402(10416):2019\u20132033","journal-title":"Lancet"},{"issue":"1","key":"2262_CR12","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1097\/BOR.0000000000000356","volume":"29","author":"BR England","year":"2017","unstructured":"England BR, Thiele GM, Mikuls TR (2017) Anticitrullinated protein antibodies: origin and role in the pathogenesis of rheumatoid arthritis. Curr Opin Rheumatol 29(1):57\u201364","journal-title":"Curr Opin Rheumatol"},{"issue":"4","key":"2262_CR13","doi-asserted-by":"publisher","first-page":"102776","DOI":"10.1016\/j.autrev.2021.102776","volume":"20","author":"FA Figus","year":"2021","unstructured":"Figus FA, Piga M, Azzolin I, McConnell R, Iagnocco A (2021) Rheumatoid arthritis: Extra-articular manifestations and comorbidities. Autoimmun Rev 20(4):102776","journal-title":"Autoimmun Rev"},{"issue":"3","key":"2262_CR14","doi-asserted-by":"publisher","first-page":"e509","DOI":"10.1002\/mco2.509","volume":"5","author":"Y Gao","year":"2024","unstructured":"Gao Y, Zhang Y, Liu X (2024) Rheumatoid arthritis: pathogenesis and therapeutic advances. MedComm (2020), 5(3):e509","journal-title":"MedComm"},{"issue":"4","key":"2262_CR15","doi-asserted-by":"publisher","first-page":"e18136","DOI":"10.1111\/jcmm.18136","volume":"28","author":"C Guo","year":"2024","unstructured":"Guo C, Yue Y, Wang B, Chen S, Li D, Zhen F, Liu L, Zhu H, Xie M (2024) Anemoside B4 alleviates arthritis pain via suppressing ferroptosis-mediated inflammation. J Cell Mol Med, 28(4),e18136.","journal-title":"J Cell Mol Med"},{"key":"2262_CR16","doi-asserted-by":"publisher","first-page":"108658","DOI":"10.1016\/j.bioorg.2025.108658","volume":"163","author":"W Guo","year":"2025","unstructured":"Guo W, Liu D, Chen Y, Ma B, Yuan F, Li H, Dai F, Hu Y, Chen Y (2025) Recent advances in small molecular inhibitors of pyruvate carboxylase for human diseases. Bioorg Chem 163:108658","journal-title":"Bioorg Chem"},{"key":"2262_CR17","first-page":"25","volume":"2","author":"F Habarou","year":"2015","unstructured":"Habarou F, Brassier A, Rio M, Chretien D, Monnot S, Barbier V, Barouki R, Bonnefont JP, Boddaert N, Chadefaux-Vekemans B, Le Moyec L, Bastin J, Ottolenghi C, de Lonlay P (2015) Pyruvate carboxylase deficiency: An underestimated cause of lactic acidosis. Mol Genet Metab Rep 2:25\u201331","journal-title":"Mol Genet Metab Rep"},{"key":"2262_CR18","doi-asserted-by":"publisher","first-page":"154416","DOI":"10.1016\/j.phymed.2022.154416","volume":"106","author":"Q Han","year":"2022","unstructured":"Han Q, Deng LR, Zou M, Tang HZ, Huang CY, Chen FJ, Tomlinson B, Li YH (2022) Anemoside B4 protects against chronic relapsing colitis in mice by modulating inflammatory response, colonic transcriptome and the gut microbiota. Phytomedicine 106:154416","journal-title":"Phytomedicine"},{"key":"2262_CR19","doi-asserted-by":"crossref","unstructured":"Hunneyball IM, Crossley MJ, Spowage M (1986) Pharmacological studies of antigen-induced arthritis in BALB\/c mice. I. Characterization of the arthritis and the effects of steroidal and non-steroidal anti-inflammatory agents. Agents Actions, 18(3\u20134), 384\u2009\u2013\u200993.","DOI":"10.1007\/BF01965002"},{"issue":"1","key":"2262_CR20","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1186\/s40170-021-00256-7","volume":"9","author":"VA Kiesel","year":"2021","unstructured":"Kiesel VA, Sheeley MP, Coleman MF, Cotul EK, Donkin SS, Hursting SD, Wendt MK, Teegarden D (2021) Pyruvate carboxylase and cancer progression. Cancer Metab 9(1):20","journal-title":"Cancer Metab"},{"issue":"6","key":"2262_CR21","doi-asserted-by":"publisher","first-page":"e97501","DOI":"10.1371\/journal.pone.0097501","volume":"9","author":"S Kim","year":"2014","unstructured":"Kim S, Hwang J, Xuan J, Jung YH, Cha HS, Kim KH (2014) Global metabolite profiling of synovial fluid for the specific diagnosis of rheumatoid arthritis from other inflammatory arthritis. PLoS ONE, 9(6),e97501.","journal-title":"PLoS ONE"},{"issue":"20","key":"2262_CR22","doi-asserted-by":"publisher","first-page":"10922","DOI":"10.3390\/ijms222010922","volume":"22","author":"N Kondo","year":"2021","unstructured":"Kondo N, Kuroda T, Kobayashi D (2021) Cytokine Networks in the Pathogenesis of Rheumatoid Arthritis. Int J Mol Sci 22(20):10922","journal-title":"Int J Mol Sci"},{"issue":"1","key":"2262_CR23","doi-asserted-by":"publisher","first-page":"108","DOI":"10.1186\/s13075-019-1896-9","volume":"21","author":"NS Lai","year":"2019","unstructured":"Lai NS, Yu HC, Tung CH, Huang KY, Huang HB, Lu MC (2019) Increased peptidylarginine deiminases expression during the macrophage differentiation and participated inflammatory responses. Arthritis Res Ther 21(1):108","journal-title":"Arthritis Res Ther"},{"issue":"10","key":"2262_CR24","doi-asserted-by":"publisher","first-page":"e567","DOI":"10.1016\/S2665-9913(23)00240-0","volume":"5","author":"CS Lau","year":"2023","unstructured":"Lau CS (2023) Burden of rheumatoid arthritis and forecasted prevalence to 2050. Lancet Rheumatol 5(10):e567\u2013e568","journal-title":"Lancet Rheumatol"},{"issue":"3","key":"2262_CR25","doi-asserted-by":"publisher","first-page":"345","DOI":"10.1007\/s00011-023-01840-x","volume":"73","author":"QH Liang","year":"2024","unstructured":"Liang QH, Li QR, Chen Z, Lv LJ, Lin Y, Jiang HL, Wang KX, Xiao MY, Kang NX, Tu PF, Ji SL, Deng KJ, Gao HW, Zhang L, Li K, Ge F, Xu GQ, Yang SL, Liu YL, Xu QM (2024) Anemoside B4, a new pyruvate carboxylase inhibitor, alleviates colitis by reprogramming macrophage function. Inflamm Res 73(3):345\u2013362","journal-title":"Inflamm Res"},{"issue":"9","key":"2262_CR26","doi-asserted-by":"publisher","first-page":"1903483","DOI":"10.1002\/advs.201903483","volume":"7","author":"Q Lin","year":"2020","unstructured":"Lin Q, He Y, Wang X, Zhang Y, Hu M, Guo W, He Y, Zhang T, Lai L, Sun Z, Yi Z, Liu M, Chen Y (2020) Targeting Pyruvate Carboxylase by a Small Molecule Suppresses Breast Cancer Progression. Adv Sci (Weinh) 7(9):1903483","journal-title":"Adv Sci (Weinh)"},{"issue":"1","key":"2262_CR27","doi-asserted-by":"publisher","first-page":"423","DOI":"10.1038\/s41420-022-01214-y","volume":"8","author":"Y Liu","year":"2022","unstructured":"Liu Y, Liu C, Pan Y, Zhou J, Ju H, Zhang Y (2022) Pyruvate carboxylase promotes malignant transformation of papillary thyroid carcinoma and reduces iodine uptake. Cell Death Discov 8(1):423","journal-title":"Cell Death Discov"},{"key":"2262_CR28","doi-asserted-by":"publisher","first-page":"28","DOI":"10.3389\/fmolb.2016.00028","volume":"3","author":"J Lloberas","year":"2016","unstructured":"Lloberas J, Valverde-Estrella L, Tur J, Vico T, Celada A (2016) Mitogen-Activated Protein Kinases and Mitogen Kinase Phosphatase 1: A Critical Interplay in Macrophage Biology. Front Mol Biosci 3:28","journal-title":"Front Mol Biosci"},{"issue":"3","key":"2262_CR29","doi-asserted-by":"publisher","first-page":"558","DOI":"10.1007\/s10875-012-9841-6","volume":"33","author":"MC Lu","year":"2013","unstructured":"Lu MC, Lai NS, Yin WY, Yu HC, Huang HB, Tung CH, Huang KY, Yu CL (2013) Anti-citrullinated protein antibodies activated ERK1\/2 and JNK mitogen-activated protein kinases via binding to surface-expressed citrullinated GRP78 on mononuclear cells. J Clin Immunol 33(3):558\u2013566","journal-title":"J Clin Immunol"},{"key":"2262_CR30","doi-asserted-by":"publisher","first-page":"936167","DOI":"10.3389\/fimmu.2022.936167","volume":"13","author":"A Marrocco","year":"2022","unstructured":"Marrocco A, Ortiz LA (2022) Role of metabolic reprogramming in pro-inflammatory cytokine secretion from LPS or silica-activated macrophages. Front Immunol 13:936167","journal-title":"Front Immunol"},{"key":"2262_CR31","doi-asserted-by":"publisher","first-page":"285","DOI":"10.1186\/s12967-014-0285-z","volume":"12","author":"AR Moore","year":"2014","unstructured":"Moore AR, Allden S, Bourne T, Denis MC, Kranidioti K, Okoye R, Sotsios Y, Stencel Z, Vugler A, Watt G, Shaw S (2014) Collagen II antibody-induced arthritis in Tg1278TNFko mice: optimization of a novel model to assess treatments targeting human TNFalpha in rheumatoid arthritis. J Transl Med 12:285","journal-title":"J Transl Med"},{"key":"2262_CR32","doi-asserted-by":"publisher","first-page":"966089","DOI":"10.3389\/fonc.2022.966089","volume":"12","author":"J Ngamkham","year":"2022","unstructured":"Ngamkham J, Siritutsoontorn S, Saisomboon S, Vaeteewoottacharn K, Jitrapakdee S (2022) CRISPR Cas9-mediated ablation of pyruvate carboxylase gene in colon cancer cell line HT-29 inhibits growth and migration, induces apoptosis and increases sensitivity to 5-fluorouracil and glutaminase inhibitor. Front Oncol 12:966089","journal-title":"Front Oncol"},{"issue":"4","key":"2262_CR33","doi-asserted-by":"publisher","first-page":"337","DOI":"10.3899\/jrheum.2023-0334","volume":"51","author":"LJ O\u2019Neil","year":"2024","unstructured":"O\u2019Neil LJ, Alpizar-Rodriguez D, Deane KD (2024) Rheumatoid Arthritis: The Continuum of Disease and Strategies for Prediction, Early Intervention, and Prevention. J Rheumatol 51(4):337\u2013349","journal-title":"J Rheumatol"},{"issue":"2","key":"2262_CR34","doi-asserted-by":"publisher","first-page":"537","DOI":"10.1016\/j.bbadis.2016.11.021","volume":"1863","author":"P Phannasil","year":"2017","unstructured":"Phannasil P, Ansari IH, Azzouny E, Longacre M, Rattanapornsompong MJ, Burant K, MacDonald CF, M. J., Jitrapakdee S (2017) Mass spectrometry analysis shows the biosynthetic pathways supported by pyruvate carboxylase in highly invasive breast cancer cells. Biochim Biophys Acta Mol Basis Dis 1863(2):537\u2013551","journal-title":"Biochim Biophys Acta Mol Basis Dis"},{"issue":"7","key":"2262_CR35","doi-asserted-by":"publisher","first-page":"527","DOI":"10.1038\/nri846","volume":"2","author":"RM Pope","year":"2002","unstructured":"Pope RM (2002) Apoptosis as a therapeutic tool in rheumatoid arthritis. Nat Rev Immunol 2(7):527\u2013535","journal-title":"Nat Rev Immunol"},{"issue":"11","key":"2262_CR36","doi-asserted-by":"publisher","first-page":"916","DOI":"10.3390\/cells13110916","volume":"13","author":"GSD Purvis","year":"2024","unstructured":"Purvis GSD, McNeill E, Wright B, Channon KM, Greaves DR (2024) Ly6C(hi) Monocytes Are Metabolically Reprogrammed in the Blood during Inflammatory Stimulation and Require Intact OxPhos for Chemotaxis and Monocyte to Macrophage Differentiation. Cells 13(11):916","journal-title":"Cells"},{"issue":"6","key":"2262_CR37","doi-asserted-by":"publisher","first-page":"e17167","DOI":"10.1016\/j.heliyon.2023.e17167","volume":"9","author":"B Qiu","year":"2023","unstructured":"Qiu B, Yuan P, Du X, Jin H, Du J, Huang Y (2023) Hypoxia inducible factor-1alpha is an important regulator of macrophage biology. Heliyon, 9(6),e17167.","journal-title":"Heliyon"},{"issue":"Pt 3","key":"2262_CR38","doi-asserted-by":"publisher","first-page":"491","DOI":"10.1042\/BST0360491","volume":"36","author":"H Sandler","year":"2008","unstructured":"Sandler H, Stoecklin G (2008) Control of mRNA decay by phosphorylation of tristetraprolin. Biochem Soc Trans 36(Pt 3):491\u2013496","journal-title":"Biochem Soc Trans"},{"issue":"1","key":"2262_CR39","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1038\/s41392-021-00807-w","volume":"7","author":"Y Shu","year":"2022","unstructured":"Shu Y, Yang N, Cheng N, Zou Z, Zhang W, Bei Y, Shi Q, Qin M, Zhu WG, Shen P (2022) Intervening pyruvate carboxylase stunts tumor growth by strengthening anti-tumor actions of tumor-associated macrophages. Signal Transduct Target Ther 7(1):34","journal-title":"Signal Transduct Target Ther"},{"key":"2262_CR40","doi-asserted-by":"publisher","first-page":"152","DOI":"10.1016\/j.bcp.2019.03.029","volume":"165","author":"E Siouti","year":"2019","unstructured":"Siouti E, Andreakos E (2019) The many facets of macrophages in rheumatoid arthritis. Biochem Pharmacol 165:152\u2013169","journal-title":"Biochem Pharmacol"},{"issue":"1","key":"2262_CR41","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1016\/S0014-5793(99)01717-2","volume":"465","author":"M Suzuki","year":"2000","unstructured":"Suzuki M, Tetsuka T, Yoshida S, Watanabe N, Kobayashi M, Matsui N, Okamoto T (2000) The role of p38 mitogen-activated protein kinase in IL-6 and IL-8 production from the TNF-alpha- or IL-1beta-stimulated rheumatoid synovial fibroblasts. FEBS Lett 465(1):23\u201327","journal-title":"FEBS Lett"},{"issue":"7444","key":"2262_CR42","doi-asserted-by":"publisher","first-page":"238","DOI":"10.1038\/nature11986","volume":"496","author":"GM Tannahill","year":"2013","unstructured":"Tannahill GM, Curtis AM, Adamik J, Palsson-McDermott EM, McGettrick AF, Goel G, Frezza C, Bernard NJ, Kelly B, Foley NH, Zheng L, Gardet A, Tong Z, Jany SS, Corr SC, Haneklaus M, Caffrey BE, Pierce K, Walmsley S, Beasley FC, Cummins E, Nizet V, Whyte M, Taylor CT, Lin H, Masters SL, Gottlieb E, Kelly VP, Clish C, Auron PE, Xavier RJ, O\u2019Neill LA (2013) Succinate is an inflammatory signal that induces IL-1\u03b2 through HIF-1\u03b1. Nature 496(7444):238\u2013242","journal-title":"Nature"},{"key":"2262_CR43","doi-asserted-by":"publisher","first-page":"RP92741","DOI":"10.7554\/eLife.92741","volume":"13","author":"M Tian","year":"2024","unstructured":"Tian M, Yang L, Zhao Z, Li J, Wang L, Yin Q, Hu W, Lou Y, Du J, Zhao P (2024) TIPE drives a cancer stem-like phenotype by promoting glycolysis via PKM2\/HIF-1alpha axis in melanoma. Elife 13:RP92741","journal-title":"Elife"},{"key":"2262_CR44","doi-asserted-by":"publisher","first-page":"2377","DOI":"10.2147\/JIR.S499345","volume":"18","author":"L Tong","year":"2025","unstructured":"Tong L, Qiu J, Xu Y, Lian S, Xu Y, Wu X (2025) Programmed Cell Death in Rheumatoid Arthritis. J Inflamm Res 18:2377\u20132393","journal-title":"J Inflamm Res"},{"issue":"7","key":"2262_CR45","doi-asserted-by":"publisher","first-page":"1284","DOI":"10.1016\/j.joca.2016.02.005","volume":"24","author":"M Udo","year":"2016","unstructured":"Udo M, Muneta T, Tsuji K, Ozeki N, Nakagawa Y, Ohara T, Saito R, Yanagisawa K, Koga H, Sekiya I (2016) Monoiodoacetic acid induces arthritis and synovitis in rats in a dose- and time-dependent manner: proposed model-specific scoring systems. Osteoarthritis Cartilage 24(7):1284\u20131291","journal-title":"Osteoarthritis Cartilage"},{"key":"2262_CR46","doi-asserted-by":"publisher","first-page":"1462","DOI":"10.3389\/fimmu.2019.01462","volume":"10","author":"A Viola","year":"2019","unstructured":"Viola A, Munari F, Sanchez-Rodriguez R, Scolaro T, Castegna A (2019) The Metabolic Signature of Macrophage Responses. Front Immunol 10:1462","journal-title":"Front Immunol"},{"key":"2262_CR48","doi-asserted-by":"publisher","first-page":"101815","DOI":"10.1016\/j.redox.2020.101815","volume":"38","author":"Q Wang","year":"2021","unstructured":"Wang Q, Wang P, Qin Z, Yang X, Pan B, Nie F, Bi H (2021) Altered glucose metabolism and cell function in keloid fibroblasts under hypoxia. Redox Biol 38:101815","journal-title":"Redox Biol"},{"issue":"16","key":"2262_CR47","doi-asserted-by":"publisher","first-page":"6210","DOI":"10.7150\/ijbs.75434","volume":"18","author":"J Wang","year":"2022","unstructured":"Wang J, Yang P, Yu T, Gao M, Liu D, Zhang J, Lu C, Chen X, Zhang X, Liu Y (2022) Lactylation of PKM2 Suppresses Inflammatory Metabolic Adaptation in Pro-inflammatory Macrophages. Int J Biol Sci 18(16):6210\u20136225","journal-title":"Int J Biol Sci"},{"key":"2262_CR49","doi-asserted-by":"publisher","first-page":"140","DOI":"10.1111\/j.1749-6632.2003.tb06042.x","volume":"987","author":"CM Weyand","year":"2003","unstructured":"Weyand CM, Goronzy JJ (2003) Ectopic germinal center formation in rheumatoid synovitis. Ann N Y Acad Sci 987:140\u2013149","journal-title":"Ann N Y Acad Sci"},{"issue":"1","key":"2262_CR50","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1111\/imr.12838","volume":"294","author":"CM Weyand","year":"2020","unstructured":"Weyand CM, Goronzy JJ (2020) Immunometabolism in the development of rheumatoid arthritis. Immunol Rev 294(1):177\u2013187","journal-title":"Immunol Rev"},{"issue":"7446","key":"2262_CR51","doi-asserted-by":"publisher","first-page":"445","DOI":"10.1038\/nature12034","volume":"496","author":"TA Wynn","year":"2013","unstructured":"Wynn TA, Chawla A, Pollard JW (2013) Macrophage biology in development, homeostasis and disease. Nature 496(7446):445\u2013455","journal-title":"Nature"},{"key":"2262_CR52","doi-asserted-by":"publisher","first-page":"961708","DOI":"10.3389\/fimmu.2022.961708","volume":"13","author":"L Xu","year":"2022","unstructured":"Xu L, Chang C, Jiang P, Wei K, Zhang R, Jin Y, Zhao J, Xu L, Shi Y, Guo S, He D (2022) Metabolomics in rheumatoid arthritis: Advances and review. Front Immunol 13:961708","journal-title":"Front Immunol"},{"key":"2262_CR53","doi-asserted-by":"crossref","unstructured":"Yang Y, Kim SC, Yu T, Yi YS, Rhee MH, Sung GH, Yoo BC, Cho JY (2014) Functional roles of p38 mitogen-activated protein kinase in macrophage-mediated inflammatory responses. Mediators Inflamm, 2014: 352371","DOI":"10.1155\/2014\/352371"},{"issue":"16","key":"2262_CR54","doi-asserted-by":"publisher","first-page":"5720","DOI":"10.3390\/ijms21165720","volume":"21","author":"HC Yu","year":"2020","unstructured":"Yu HC, Tung CH, Huang KY, Huang HB, Lu MC (2020) The essential role of peptidylarginine deiminases 2 for cytokines secretion, apoptosis, and cell adhesion in macrophage. Int J Mol Sci 21(16):5720","journal-title":"Int J Mol Sci"},{"issue":"9","key":"2262_CR55","doi-asserted-by":"publisher","first-page":"2708","DOI":"10.1002\/art.21236","volume":"52","author":"Q Zhang","year":"2005","unstructured":"Zhang Q, Badell IR, Schwarz EM, Boulukos KE, Yao Z, Boyce BF, Xing L (2005) Tumor necrosis factor prevents alendronate-induced osteoclast apoptosis in vivo by stimulating Bcl-xL expression through Ets-2. Arthritis Rheum 52(9):2708\u20132718","journal-title":"Arthritis Rheum"},{"key":"2262_CR56","doi-asserted-by":"crossref","unstructured":"Zhao LN, Wang RL, Liu RX, Zheng MR, Zhao L, Li BF, Li JL, Liu DS, He XX, Peng QB, Li K, Lin TX, Liu YY, He SP, Lu J, Zheng SY, Liu X, Huang FZ (2025) Pyruvate carboxylase in macrophages aggravates atherosclerosis by regulating metabolism reprogramming to promote inflammatory responses through the hypoxia-inducible factor-1 signaling pathway. Adv Sci (Weinh), 12(29), e17128.","DOI":"10.1002\/advs.202417128"}],"container-title":["Inflammopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10787-026-02262-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10787-026-02262-x","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10787-026-02262-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T13:02:44Z","timestamp":1781701364000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10787-026-02262-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,20]]},"references-count":56,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2026,6]]}},"alternative-id":["2262"],"URL":"https:\/\/doi.org\/10.1007\/s10787-026-02262-x","relation":{},"ISSN":["0925-4692","1568-5608"],"issn-type":[{"value":"0925-4692","type":"print"},{"value":"1568-5608","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,20]]},"assertion":[{"value":"14 September 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 May 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 May 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"None.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}