{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,30]],"date-time":"2026-08-30T10:04:03Z","timestamp":1788084243490,"version":"build-2784847793"},"reference-count":155,"publisher":"Springer Science and Business Media LLC","issue":"7","license":[{"start":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T00:00:00Z","timestamp":1780358400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T00:00:00Z","timestamp":1780358400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Inflammopharmacol"],"published-print":{"date-parts":[[2026,7]]},"DOI":"10.1007\/s10787-026-02274-7","type":"journal-article","created":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T14:33:18Z","timestamp":1780410798000},"page":"4345-4365","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Decoding neuroinflammation: the critical role of NLRP3 inflammasome in Alzheimer\u2019s disease"],"prefix":"10.1007","volume":"34","author":[{"given":"Bharat","family":"Chaudhary","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sneha","family":"Kumari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prajjwal","family":"Sharma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rishika","family":"Dhapola","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohit","family":"Paidlewar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Balachandar","family":"Vellingiri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bikash","family":"Medhi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2616-0195","authenticated-orcid":false,"given":"Dibbanti","family":"HariKrishnaReddy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,6,2]]},"reference":[{"key":"2274_CR1","doi-asserted-by":"publisher","first-page":"1111","DOI":"10.1089\/ars.2014.5994","volume":"22","author":"JM Abais","year":"2015","unstructured":"Abais JM, Xia M, Zhang Y et al (2015) Redox regulation of NLRP3 inflammasomes: ROS as trigger or effector? Antioxid Redox Signal 22:1111\u20131129. https:\/\/doi.org\/10.1089\/ars.2014.5994","journal-title":"Antioxid Redox Signal"},{"key":"2274_CR2","doi-asserted-by":"publisher","first-page":"1281","DOI":"10.1007\/s00213-018-5137-8","volume":"236","author":"M Amani","year":"2019","unstructured":"Amani M, Shokouhi G, Salari A-A (2019) Minocycline prevents the development of depression-like behavior and hippocampal inflammation in a rat model of Alzheimer\u2019s disease. Psychopharmacology 236:1281\u20131292","journal-title":"Psychopharmacology"},{"key":"2274_CR3","doi-asserted-by":"publisher","first-page":"6299","DOI":"10.1016\/j.cell.2021.11.011","volume":"184","author":"L Andreeva","year":"2021","unstructured":"Andreeva L, David L, Rawson S et al (2021) NLRP3 cages revealed by full-length mouse NLRP3 structure control pathway activation. Cell 184:6299-6312.e22. https:\/\/doi.org\/10.1016\/j.cell.2021.11.011","journal-title":"Cell"},{"key":"2274_CR4","doi-asserted-by":"publisher","first-page":"1","DOI":"10.21775\/cimb.036.001","volume":"36","author":"Y Ano","year":"2020","unstructured":"Ano Y, Sakudo A, Onodera T (2020) Effect of microglial inflammation in prion disease. Curr Issues Mol Biol 36:1\u201312","journal-title":"Curr Issues Mol Biol"},{"key":"2274_CR5","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s11481-025-10210-9","volume":"20","author":"DR Ashvin","year":"2025","unstructured":"Ashvin DR, Kumari S et al (2025) Unraveling the immune puzzle: role of immunomodulation in Alzheimer\u2019s disease. J Neuroimmune Pharmacol 20:1\u201316. https:\/\/doi.org\/10.1007\/s11481-025-10210-9","journal-title":"J Neuroimmune Pharmacol"},{"key":"2274_CR6","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2021.720490","volume":"9","author":"A Bahat","year":"2021","unstructured":"Bahat A, MacVicar T, Langer T (2021) Metabolism and innate immunity meet at the mitochondria. Front Cell Dev Biol 9:720490","journal-title":"Front Cell Dev Biol"},{"key":"2274_CR7","doi-asserted-by":"publisher","first-page":"180","DOI":"10.1016\/j.yexcr.2017.11.015","volume":"362","author":"H Bai","year":"2018","unstructured":"Bai H, Yang B, Yu W et al (2018) Cathepsin B links oxidative stress to the activation of NLRP3 inflammasome. Exp Cell Res 362:180\u2013187","journal-title":"Exp Cell Res"},{"key":"2274_CR8","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1186\/s13195-023-01330-6","volume":"15","author":"D Balu","year":"2023","unstructured":"Balu D, Valencia-Olvera AC, Nguyen A et al (2023) A small-molecule TLR4 antagonist reduced neuroinflammation in female E4FAD mice. Alzheimers Res Ther 15:181. https:\/\/doi.org\/10.1186\/s13195-023-01330-6","journal-title":"Alzheimers Res Ther"},{"key":"2274_CR9","doi-asserted-by":"publisher","first-page":"787","DOI":"10.4049\/jimmunol.0901363","volume":"183","author":"FG Bauernfeind","year":"2009","unstructured":"Bauernfeind FG, Horvath G, Stutz A et al (2009) Cutting edge: NF-kappaB activating pattern recognition and cytokine receptors license NLRP3 inflammasome activation by regulating NLRP3 expression. J Immunol 183:787\u2013791. https:\/\/doi.org\/10.4049\/jimmunol.0901363","journal-title":"J Immunol"},{"key":"2274_CR10","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1177\/13872877241283677","volume":"102","author":"N Beder","year":"2024","unstructured":"Beder N, Belkhelfa M, Leklou H (2024) Involvement of inflammasomes in the pathogenesis of Alzheimer\u2019s disease. J Alzheimers Dis 102:11\u201329","journal-title":"J Alzheimers Dis"},{"key":"2274_CR11","doi-asserted-by":"publisher","first-page":"679","DOI":"10.1007\/s10787-024-01598-6","volume":"33","author":"V Bhardwaj","year":"2025","unstructured":"Bhardwaj V, Kumari S, Dhapola R et al (2025) Shedding light on microglial dysregulation in Alzheimer\u2019s disease: exploring molecular mechanisms and therapeutic avenues. Inflammopharmacology 33:679\u2013702. https:\/\/doi.org\/10.1007\/s10787-024-01598-6","journal-title":"Inflammopharmacology"},{"key":"2274_CR12","doi-asserted-by":"publisher","first-page":"692","DOI":"10.1038\/s41590-022-01185-3","volume":"23","author":"LK Billingham","year":"2022","unstructured":"Billingham LK, Stoolman JS, Vasan K et al (2022) Mitochondrial electron transport chain is necessary for NLRP3 inflammasome activation. Nat Immunol 23:692\u2013704","journal-title":"Nat Immunol"},{"key":"2274_CR13","doi-asserted-by":"publisher","unstructured":"Calvo-rodr\u00edguez M, Fuente C De, Garc\u00eda-durillo M, et al (2017) Aging and amyloid \u03b2 oligomers enhance responses, and neuron cell death in cultured rat hippocampal neurons. 1\u201313. https:\/\/doi.org\/10.1186\/s12974-017-0802-0","DOI":"10.1186\/s12974-017-0802-0"},{"key":"2274_CR14","doi-asserted-by":"publisher","first-page":"790","DOI":"10.1016\/j.immuni.2024.03.010","volume":"57","author":"S Castro-Gomez","year":"2024","unstructured":"Castro-Gomez S, Heneka MT (2024) Innate immune activation in neurodegenerative diseases. Immunity 57:790\u2013814. https:\/\/doi.org\/10.1016\/j.immuni.2024.03.010","journal-title":"Immunity"},{"key":"2274_CR15","doi-asserted-by":"publisher","unstructured":"Chaudhary B, Kumari S, Dhapola R, et al (2025) Calcium dysregulation in Alzheimer\u2019s disease: unraveling the molecular nexus of neuronal dysfunction and therapeutic opportunities. Biochem Pharmacol 242. https:\/\/doi.org\/10.1016\/j.bcp.2025.117211","DOI":"10.1016\/j.bcp.2025.117211"},{"key":"2274_CR16","doi-asserted-by":"publisher","first-page":"315","DOI":"10.1186\/s12974-022-02682-w","volume":"19","author":"C Chen","year":"2022","unstructured":"Chen C, Zhou Y, Ning X et al (2022) Directly targeting ASC by lonidamine alleviates inflammasome-driven diseases. J Neuroinflammation 19:315. https:\/\/doi.org\/10.1186\/s12974-022-02682-w","journal-title":"J Neuroinflammation"},{"key":"2274_CR17","doi-asserted-by":"publisher","DOI":"10.1038\/srep42370","volume":"7","author":"C Criscuolo","year":"2017","unstructured":"Criscuolo C, Fontebasso V, Middei S et al (2017) Entorhinal Cortex dysfunction can be rescued by inhibition of microglial RAGE in an Alzheimer\u2019s disease mouse model. Sci Rep 7:42370. https:\/\/doi.org\/10.1038\/srep42370","journal-title":"Sci Rep"},{"issue":"4","key":"2274_CR18","doi-asserted-by":"publisher","first-page":"1877","DOI":"10.1152\/physrev.00018.2018","volume":"99","author":"JF Cryan","year":"2019","unstructured":"Cryan JF, O'Riordan KJ, Cowan CS, Sandhu KV, Bastiaanssen TF, Boehme M, Codagnone MG, Cussotto S, Fulling C, Golubeva AV, Guzzetta KE (2019) The microbiota-gut-brain axis. Physiol Rev 99(4):1877\u20132013","journal-title":"Physiol Rev"},{"key":"2274_CR19","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2020.00444","volume":"14","author":"W Cui","year":"2020","unstructured":"Cui W, Sun C, Ma Y et al (2020) Inhibition of TLR4 induces M2 microglial polarization and provides neuroprotection via the NLRP3 inflammasome in Alzheimer\u2019s disease. Front Neurosci 14:444","journal-title":"Front Neurosci"},{"key":"2274_CR20","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms12504","author":"MJD Daniels","year":"2016","unstructured":"Daniels MJD, Rivers-Auty J, Schilling T et al (2016) Fenamate NSAIDs inhibit the NLRP3 inflammasome and protect against Alzheimer\u2019s disease in rodent models. Nat Commun. https:\/\/doi.org\/10.1038\/ncomms12504","journal-title":"Nat Commun"},{"key":"2274_CR21","doi-asserted-by":"publisher","first-page":"306","DOI":"10.1016\/j.bbi.2016.12.014","volume":"61","author":"C Dempsey","year":"2017","unstructured":"Dempsey C, Rubio Araiz A, Bryson KJ et al (2017) Inhibiting the NLRP3 inflammasome with MCC950 promotes non-phlogistic clearance of amyloid-\u03b2 and cognitive function in APP\/PS1 mice. Brain Behav Immun 61:306\u2013316. https:\/\/doi.org\/10.1016\/j.bbi.2016.12.014","journal-title":"Brain Behav Immun"},{"key":"2274_CR22","doi-asserted-by":"publisher","DOI":"10.1038\/nm.3893","author":"C Deng","year":"2021","unstructured":"Deng C, Cai X, Jin K, Wang Q (2021). Editorial\u202f: the NLRP neuroinflammation and its related mitochondrial impairment in neurodegeneration. https:\/\/doi.org\/10.1038\/nm.3893","journal-title":"Editorial : the NLRP Neuroinflammation and Its Related Mitochondrial Impairment in Neurodegeneration"},{"key":"2274_CR23","doi-asserted-by":"publisher","first-page":"1669","DOI":"10.1007\/s10787-021-00889-6","volume":"29","author":"R Dhapola","year":"2021","unstructured":"Dhapola R, Hota SS, Sarma P et al (2021) Recent advances in molecular pathways and therapeutic implications targeting neuroinflammation for Alzheimer\u2019s disease. Inflammopharmacology 29:1669\u20131681. https:\/\/doi.org\/10.1007\/s10787-021-00889-6","journal-title":"Inflammopharmacology"},{"key":"2274_CR24","doi-asserted-by":"publisher","first-page":"535","DOI":"10.1007\/s12035-021-02612-6","volume":"59","author":"R Dhapola","year":"2022","unstructured":"Dhapola R, Sarma P, Medhi B et al (2022) Recent advances in molecular pathways and therapeutic implications targeting mitochondrial dysfunction for Alzheimer\u2019s disease. Mol Neurobiol 59:535\u2013555. https:\/\/doi.org\/10.1007\/s12035-021-02612-6","journal-title":"Mol Neurobiol"},{"key":"2274_CR25","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s42826-023-00184-1","volume":"39","author":"R Dhapola","year":"2023","unstructured":"Dhapola R, Kumari S, Sharma P, HariKrishnaReddy D (2023) Insight into the emerging and common experimental in-vivo models of Alzheimer\u2019s disease. Lab Anim Res 39:1\u201318. https:\/\/doi.org\/10.1186\/s42826-023-00184-1","journal-title":"Lab Anim Res"},{"key":"2274_CR26","doi-asserted-by":"publisher","DOI":"10.1007\/s12035-025-05216-6","author":"R Dhapola","year":"2025","unstructured":"Dhapola R, Kumari S, Sharma P et al (2025a) Deciphering molecular and signaling pathways of extracellular vesicles-based therapeutics for Alzheimer\u2019s disease. Mol Neurobiol. https:\/\/doi.org\/10.1007\/s12035-025-05216-6","journal-title":"Mol Neurobiol"},{"key":"2274_CR27","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2025.149494","volume":"1851","author":"R Dhapola","year":"2025","unstructured":"Dhapola R, Kumari S, Sharma P et al (2025b) Advancements in autophagy perturbations in Alzheimer\u2019s disease: molecular aspects and therapeutics. Brain Res 1851:149494. https:\/\/doi.org\/10.1016\/j.brainres.2025.149494","journal-title":"Brain Res"},{"key":"2274_CR28","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2025.114902","volume":"159","author":"R Dhapola","year":"2025","unstructured":"Dhapola R, Paidlewar M, Kumari S et al (2025c) cGAS-STING and neurodegenerative diseases: a molecular crosstalk and therapeutic perspective. Int Immunopharmacol 159:114902. https:\/\/doi.org\/10.1016\/j.intimp.2025.114902","journal-title":"Int Immunopharmacol"},{"key":"2274_CR29","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.cytogfr.2026.01.001","volume":"88","author":"R Dhapola","year":"2026","unstructured":"Dhapola R, Kumari S, Sharma P, Paidlewar M (2026) Cytokine and growth factor reviews cytokine associated neuroinflammation in Parkinson \u2019 s disease\u202f: molecular pathways , therapeutic targets , and translational insights. Cytokine Growth Factor Rev 88:1\u201317. https:\/\/doi.org\/10.1016\/j.cytogfr.2026.01.001","journal-title":"Cytokine Growth Factor Rev"},{"key":"2274_CR30","doi-asserted-by":"publisher","first-page":"3047","DOI":"10.4049\/jimmunol.1701723","volume":"200","author":"EI Elliott","year":"2018","unstructured":"Elliott EI, Miller AN, Banoth B et al (2018) Cutting edge: mitochondrial assembly of the NLRP3 inflammasome complex is initiated at priming. J Immunol 200:3047\u20133052","journal-title":"J Immunol"},{"key":"2274_CR31","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2023.110287","volume":"120","author":"M Fan","year":"2023","unstructured":"Fan M, Wang C, Zhao X et al (2023) Parthenolide alleviates microglia\u2010mediated neuroinflammation via MAPK\/TRIM31\/NLRP3 signaling to ameliorate cognitive disorder. Int Immunopharmacol 120:110287. https:\/\/doi.org\/10.1016\/j.intimp.2023.110287","journal-title":"Int Immunopharmacol"},{"key":"2274_CR32","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2024.111869","volume":"131","author":"M Fang","year":"2024","unstructured":"Fang M, Xia F, Wang J et al (2024) The NLRP3 inhibitor, OLT1177 attenuates brain injury in experimental intracerebral hemorrhage. Int Immunopharmacol 131:111869","journal-title":"Int Immunopharmacol"},{"key":"2274_CR33","doi-asserted-by":"publisher","first-page":"1207","DOI":"10.1111\/cns.12983","volume":"24","author":"J Feng","year":"2018","unstructured":"Feng J, Wang J, Du Y et al (2018) Dihydromyricetin inhibits microglial activation and neuroinflammation by suppressing NLRP 3 inflammasome activation in APP\/PS 1 transgenic mice. CNS Neurosci Ther 24:1207\u20131218","journal-title":"CNS Neurosci Ther"},{"key":"2274_CR34","doi-asserted-by":"publisher","first-page":"2167","DOI":"10.15252\/embj.201695415","volume":"35","author":"MM Gaidt","year":"2016","unstructured":"Gaidt MM, Hornung V (2016) Pore formation by GSDMD is the effector mechanism of pyroptosis. EMBO J 35:2167\u20132169. https:\/\/doi.org\/10.15252\/embj.201695415","journal-title":"EMBO J"},{"key":"2274_CR35","doi-asserted-by":"publisher","first-page":"369","DOI":"10.1007\/s00018-022-04297-z","volume":"79","author":"C Gallo","year":"2022","unstructured":"Gallo C, Manzo E, Barra G et al (2022) Sulfavant A as the first synthetic TREM2 ligand discloses a homeostatic response of dendritic cells after receptor engagement. Cell Mol Life Sci 79:369","journal-title":"Cell Mol Life Sci"},{"key":"2274_CR36","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-023-01588-0","volume":"8","author":"C Gao","year":"2023","unstructured":"Gao C, Jiang J, Tan Y, Chen S (2023) Microglia in neurodegenerative diseases: mechanism and potential therapeutic targets. Signal Transduct Target Ther 8:359. https:\/\/doi.org\/10.1038\/s41392-023-01588-0","journal-title":"Signal Transduct Target Ther"},{"key":"2274_CR37","doi-asserted-by":"publisher","first-page":"2606","DOI":"10.1007\/s12035-018-1211-9","volume":"56","author":"ML Garcez","year":"2019","unstructured":"Garcez ML, Mina F, Bellettini-Santos T et al (2019) The involvement of NLRP3 on the effects of Minocycline in an AD-like pathology induced by \u03b2-Amyloid oligomers administered to mice. Mol Neurobiol 56:2606\u20132617. https:\/\/doi.org\/10.1007\/s12035-018-1211-9","journal-title":"Mol Neurobiol"},{"key":"2274_CR38","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2024-198326","volume":"144","author":"G Garcia-Manero","year":"2024","unstructured":"Garcia-Manero G, Abaza Y, Greenberg PL et al (2024) Preliminary safety and biomarker results of the NLRP3 inflammasome inhibitor DFV890 in adult patients with myeloid diseases: a phase 1b study. Blood 144:353. https:\/\/doi.org\/10.1182\/blood-2024-198326","journal-title":"Blood"},{"key":"2274_CR39","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2021.659097","volume":"12","author":"T Glaser","year":"2021","unstructured":"Glaser T, Oliveira-Giacomelli \u00c1, Petiz LL et al (2021) Antagonistic roles of P2X7 and P2Y2 receptors in neurodegenerative diseases. Front Pharmacol 12:659097. https:\/\/doi.org\/10.3389\/fphar.2021.659097","journal-title":"Front Pharmacol"},{"key":"2274_CR40","doi-asserted-by":"publisher","first-page":"579","DOI":"10.3233\/JAD-210660","volume":"84","author":"M Golzari-Sorkheh","year":"2021","unstructured":"Golzari-Sorkheh M, Brown CE, Weaver DF, Reed MA (2021) The NLRP3 inflammasome in the pathogenesis and treatment of Alzheimer\u2019s disease. J Alzheimers Dis 84:579\u2013598","journal-title":"J Alzheimers Dis"},{"key":"2274_CR41","doi-asserted-by":"publisher","first-page":"E9371","DOI":"10.1073\/pnas.1812744115","volume":"115","author":"JP Green","year":"2018","unstructured":"Green JP, Yu S, Mart\u00edn-S\u00e1nchez F et al (2018) Chloride regulates dynamic NLRP3-dependent ASC oligomerization and inflammasome priming. Proc Natl Acad Sci U S A 115:E9371\u2013E9380","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2274_CR42","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1016\/j.coi.2018.03.010","volume":"52","author":"I Hafner-Bratkovi\u010d","year":"2018","unstructured":"Hafner-Bratkovi\u010d I, Pelegr\u00edn P (2018) Ion homeostasis and ion channels in NLRP3 inflammasome activation and regulation. Curr Opin Immunol 52:8\u201317. https:\/\/doi.org\/10.1016\/j.coi.2018.03.010","journal-title":"Curr Opin Immunol"},{"key":"2274_CR43","doi-asserted-by":"publisher","first-page":"857","DOI":"10.1038\/ni.1636","volume":"9","author":"A Halle","year":"2008","unstructured":"Halle A, Hornung V, Petzold GC et al (2008) The NALP3 inflammasome is involved in the innate immune response to amyloid-beta. Nat Immunol 9:857\u2013865. https:\/\/doi.org\/10.1038\/ni.1636","journal-title":"Nat Immunol"},{"key":"2274_CR44","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s12974-020-02022-w","volume":"17","author":"HJ Ham","year":"2020","unstructured":"Ham HJ, Lee YS, Yun J et al (2020) K284\u20136111 alleviates memory impairment and neuroinflammation in Tg2576 mice by inhibition of Chitinase-3-like 1 regulating ERK-dependent PTX3 pathway. J Neuroinflammation 17:1\u201316","journal-title":"J Neuroinflammation"},{"key":"2274_CR45","doi-asserted-by":"publisher","DOI":"10.3390\/antiox12030722","author":"S Han","year":"2023","unstructured":"Han S, He Z, Hu X et al (2023) Inhibiting NLRP3 inflammasome activation by CY-09 helps to restore cerebral glucose metabolism in 3\u00d7Tg-AD mice. Antioxidants Basel. https:\/\/doi.org\/10.3390\/antiox12030722","journal-title":"Antioxidants Basel"},{"key":"2274_CR46","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2020.570711","volume":"11","author":"KL Hanslik","year":"2020","unstructured":"Hanslik KL, Ulland TK (2020) The role of microglia and the Nlrp3 inflammasome in Alzheimer\u2019s disease. Front Neurol 11:570711","journal-title":"Front Neurol"},{"key":"2274_CR47","doi-asserted-by":"publisher","DOI":"10.1038\/srep41802","volume":"7","author":"T Harach","year":"2017","unstructured":"Harach T, Marungruang N, Duthilleul N et al (2017) Reduction of Abeta amyloid pathology in APPPS1 transgenic mice in the absence of gut microbiota. Sci Rep 7:41802","journal-title":"Sci Rep"},{"key":"2274_CR48","doi-asserted-by":"publisher","first-page":"1733","DOI":"10.1111\/bph.13425","volume":"174","author":"J Haslund-Vinding","year":"2017","unstructured":"Haslund-Vinding J, McBean G, Jaquet V, Vilhardt F (2017) NADPH oxidases in oxidant production by microglia: activating receptors, pharmacology and association with disease. Br J Pharmacol 174:1733\u20131749. https:\/\/doi.org\/10.1111\/bph.13425","journal-title":"Br J Pharmacol"},{"key":"2274_CR49","doi-asserted-by":"publisher","first-page":"354","DOI":"10.1038\/nature16959","volume":"530","author":"Y He","year":"2016","unstructured":"He Y, Zeng MY, Yang D et al (2016) NEK7 is an essential mediator of NLRP3 activation downstream of potassium efflux. Nature 530:354\u2013357","journal-title":"Nature"},{"key":"2274_CR50","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-04947-6","volume":"9","author":"H He","year":"2018","unstructured":"He H, Jiang H, Chen Y et al (2018) Oridonin is a covalent NLRP3 inhibitor with strong anti-inflammasome activity. Nat Commun 9:2550. https:\/\/doi.org\/10.1038\/s41467-018-04947-6","journal-title":"Nat Commun"},{"key":"2274_CR51","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2021.643254","volume":"12","author":"JA Holbrook","year":"2021","unstructured":"Holbrook JA, Jarosz-Griffiths HH, Caseley E et al (2021) Neurodegenerative disease and the NLRP3 inflammasome. Front Pharmacol 12:643254","journal-title":"Front Pharmacol"},{"key":"2274_CR52","doi-asserted-by":"publisher","first-page":"669","DOI":"10.1038\/s41586-019-1769-z","volume":"575","author":"C Ising","year":"2019","unstructured":"Ising C, Venegas C, Zhang S et al (2019) NLRP3 inflammasome activation drives tau pathology. Nature 575:669\u2013673","journal-title":"Nature"},{"key":"2274_CR53","doi-asserted-by":"publisher","unstructured":"Ismael S, Wajidunnisa, Sakata K, et al (2021) ER stress associated TXNIP-NLRP3 inflammasome activation in hippocampus of human Alzheimer\u2019s disease. Neurochem Int 148:105104. https:\/\/doi.org\/10.1016\/j.neuint.2021.105104","DOI":"10.1016\/j.neuint.2021.105104"},{"key":"2274_CR54","doi-asserted-by":"publisher","first-page":"389","DOI":"10.1007\/s40265-023-01838-z","volume":"83","author":"N Jayabalan","year":"2023","unstructured":"Jayabalan N, Oronsky B, Cabrales P et al (2023) A review of RRx-001: a late-stage multi-indication inhibitor of NLRP3 activation and chronic inflammation. Drugs 83:389\u2013402. https:\/\/doi.org\/10.1007\/s40265-023-01838-z","journal-title":"Drugs"},{"key":"2274_CR55","doi-asserted-by":"publisher","first-page":"3574","DOI":"10.1111\/jnc.15788","volume":"168","author":"D Jha","year":"2024","unstructured":"Jha D, Bakker ENTP, Kumar R (2024) Mechanistic and therapeutic role of NLRP3 inflammasome in the pathogenesis of Alzheimer\u2019s disease. J Neurochem 168:3574\u20133598. https:\/\/doi.org\/10.1111\/jnc.15788","journal-title":"J Neurochem"},{"key":"2274_CR56","doi-asserted-by":"publisher","unstructured":"Jiang S, Maphis NM, Binder J, et al (2021) Proteopathic tau primes and activates interleukin-1\u03b2; via myeloid-cell-specific MyD88- and NLRP3-ASC-inflammasome pathway. Cell Rep 36:. https:\/\/doi.org\/10.1016\/j.celrep.2021.109720","DOI":"10.1016\/j.celrep.2021.109720"},{"key":"2274_CR57","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-022-02558-z","author":"P Jin","year":"2022","unstructured":"Jin P, Qi D, Cui Y et al (2022) Aprepitant attenuates NLRC4 \u2011 dependent neuronal pyroptosis via NK1R \/ PKC\u03b4 pathway in a mouse model of intracerebral hemorrhage. J Neuroinflammation. https:\/\/doi.org\/10.1186\/s12974-022-02558-z","journal-title":"J Neuroinflammation"},{"key":"2274_CR58","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2024.1402573","volume":"16","author":"F Karimani","year":"2024","unstructured":"Karimani F, Asgari Taei A, Abolghasemi-Dehaghani M-R et al (2024) Impairment of entorhinal cortex network activity in Alzheimer\u2019s disease. Front Aging Neurosci 16:1402573. https:\/\/doi.org\/10.3389\/fnagi.2024.1402573","journal-title":"Front Aging Neurosci"},{"key":"2274_CR59","doi-asserted-by":"publisher","first-page":"758","DOI":"10.1080\/08923973.2021.1981374","volume":"43","author":"A Karkhah","year":"2021","unstructured":"Karkhah A, Mahdiye S, Fereshteh P et al (2021) Indomethacin attenuates neuroinflammation and memory impairment in an STZ-induced model of Alzheimer\u2019s like disease. Immunopharmacol Immunotoxicol 43:758\u2013766. https:\/\/doi.org\/10.1080\/08923973.2021.1981374","journal-title":"Immunopharmacol Immunotoxicol"},{"key":"2274_CR60","doi-asserted-by":"publisher","unstructured":"Kelley N, Jeltema D, Duan Y, He Y (2019) The NLRP3 inflammasome: an overview of mechanisms of activation and regulation. Int J Mol Sci 20:. https:\/\/doi.org\/10.3390\/ijms20133328","DOI":"10.3390\/ijms20133328"},{"key":"2274_CR61","doi-asserted-by":"publisher","first-page":"686","DOI":"10.14283\/jpad.2023.109","volume":"10","author":"M Kiraly","year":"2023","unstructured":"Kiraly M, Foss JF, Giordano T (2023) Neuroinflammation, its role in Alzheimer\u2019s disease and therapeutic strategies. J Prev Alzheimers Dis 10:686\u2013698. https:\/\/doi.org\/10.14283\/jpad.2023.109","journal-title":"J Prev Alzheimers Dis"},{"key":"2274_CR62","doi-asserted-by":"publisher","DOI":"10.1002\/ctm2.1471","volume":"13","author":"B Klughammer","year":"2023","unstructured":"Klughammer B, Piali L, Nica A et al (2023) A powerful, reversible, selective, and orally administered small molecule NLRP3 inhibitor is selnoflast. Clin Transl Med 13:e1471","journal-title":"Clin Transl Med"},{"key":"2274_CR63","unstructured":"Kucharska E (2022) Targeting NLRP3-mediated neuroinflammation in Alzheimer \u2018 s disease treatment"},{"key":"2274_CR64","doi-asserted-by":"publisher","first-page":"943","DOI":"10.1007\/s10495-023-01848-y","volume":"28","author":"S Kumari","year":"2023","unstructured":"Kumari S, Dhapola R, Reddy DHK (2023a) Apoptosis in Alzheimer\u2019s disease: insight into the signaling pathways and therapeutic avenues. Apoptosis 28:943\u2013957. https:\/\/doi.org\/10.1007\/s10495-023-01848-y","journal-title":"Apoptosis"},{"key":"2274_CR65","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2023.102098","volume":"92","author":"S Kumari","year":"2023","unstructured":"Kumari S, Dhapola R, Sharma P et al (2023b) Implicative role of cytokines in neuroinflammation mediated AD and associated signaling pathways: current progress in molecular signaling and therapeutics. Ageing Res Rev 92:102098. https:\/\/doi.org\/10.1016\/j.arr.2023.102098","journal-title":"Ageing Res Rev"},{"key":"2274_CR66","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2025.102883","volume":"112","author":"S Kumari","year":"2025","unstructured":"Kumari S, Dhapola R, Sharma P et al (2025) Unravelling neuronal death mechanisms: the role of cytokines and chemokines in immune imbalance in Alzheimer\u2019s disease progression. Ageing Res Rev 112:102883. https:\/\/doi.org\/10.1016\/j.arr.2025.102883","journal-title":"Ageing Res Rev"},{"key":"2274_CR67","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2025.102928","volume":"113","author":"S Kumari","year":"2026","unstructured":"Kumari S, Dhapola R, Sharma P, Paidlewar M (2026) Three-dimensional human brain organoids\u202f: a next-generation model to decode Alzheimer \u2019 s disease. Ageing Res Rev 113:102928. https:\/\/doi.org\/10.1016\/j.arr.2025.102928","journal-title":"Ageing Res Rev"},{"key":"2274_CR68","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1146\/annurev-cellbio-101011-155745","volume":"28","author":"M Lamkanfi","year":"2012","unstructured":"Lamkanfi M, Dixit VM (2012) 10.1146\/annurev-cellbio-101011-155745. Annu Rev Cell Dev Biol 28:137\u2013161. https:\/\/doi.org\/10.1146\/annurev-cellbio-101011-155745","journal-title":"Annu Rev Cell Dev Biol"},{"key":"2274_CR69","doi-asserted-by":"publisher","DOI":"10.1016\/j.jlr.2024.100554","author":"X Li","year":"2024","unstructured":"Li X, Sallam T (2024) A (cholesterol) crystal clear path to inflammasome activation in atherosclerosis. J Lipid Res. https:\/\/doi.org\/10.1016\/j.jlr.2024.100554","journal-title":"J Lipid Res"},{"key":"2274_CR70","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1093\/abbs\/gmaa155","volume":"53","author":"C Li","year":"2021","unstructured":"Li C, Chen M, He X, Ouyang D (2021) A mini-review on ion fluxes that regulate NLRP3 inflammasome activation. Acta Biochim Biophys Sin (Shanghai) 53:131\u2013139. https:\/\/doi.org\/10.1093\/abbs\/gmaa155","journal-title":"Acta Biochim Biophys Sin (Shanghai)"},{"key":"2274_CR71","doi-asserted-by":"publisher","first-page":"145","DOI":"10.3164\/jcbn.22-105","volume":"73","author":"P Li","year":"2023","unstructured":"Li P, He Y, Yang Q et al (2023a) NEK7 inhibition attenuates A\u03b242-induced cognitive impairment by regulating TLR4\/NF-\u03baB and the NLRP3 inflammasome in mice. J Clin Biochem Nutr 73:145","journal-title":"J Clin Biochem Nutr"},{"key":"2274_CR72","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1016\/j.smhs.2023.09.009","volume":"5","author":"X Li","year":"2023","unstructured":"Li X, Jin Y, Ding X et al (2023b) Long-term exercise training inhibits inflammation by suppressing hippocampal NLRP3 in APP\/PS1 mice. Sport Med Heal Sci 5:329\u2013335. https:\/\/doi.org\/10.1016\/j.smhs.2023.09.009","journal-title":"Sport Med Heal Sci"},{"key":"2274_CR73","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3389\/fphar.2022.845185","volume":"13","author":"T Liang","year":"2022","unstructured":"Liang T, Zhang Y, Wu S et al (2022) The role of NLRP3 inflammasome in Alzheimer\u2019s disease and potential therapeutic targets. Front Pharmacol 13:1\u201321. https:\/\/doi.org\/10.3389\/fphar.2022.845185","journal-title":"Front Pharmacol"},{"key":"2274_CR74","doi-asserted-by":"publisher","DOI":"10.1111\/cns.14704","volume":"30","author":"J Liang","year":"2024","unstructured":"Liang J, Wang Y, Liu B et al (2024) Deciphering the intricate linkage between the gut microbiota and Alzheimer\u2019s disease: elucidating mechanistic pathways promising therapeutic strategies. CNS Neurosci Ther 30:e14704","journal-title":"CNS Neurosci Ther"},{"key":"2274_CR75","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2021.111405","volume":"138","author":"A Lindsay","year":"2021","unstructured":"Lindsay A, Hickman D, Srinivasan M (2021) A nuclear factor-kappa B inhibiting peptide suppresses innate immune receptors and gliosis in a transgenic mouse model of Alzheimer\u2019s disease. Biomed Pharmacother 138:111405. https:\/\/doi.org\/10.1016\/j.biopha.2021.111405","journal-title":"Biomed Pharmacother"},{"key":"2274_CR76","doi-asserted-by":"publisher","DOI":"10.3390\/ph14121221","author":"A Litwiniuk","year":"2021","unstructured":"Litwiniuk A, Baranowska-Bik A, Doma\u0144ska A et al (2021) Contribution of mitochondrial dysfunction combined with NLRP3 inflammasome activation in selected neurodegenerative diseases. Pharmaceuticals Basel. https:\/\/doi.org\/10.3390\/ph14121221","journal-title":"Pharmaceuticals Basel"},{"key":"2274_CR77","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1016\/j.molimm.2018.09.010","volume":"103","author":"Q Liu","year":"2018","unstructured":"Liu Q, Zhang D, Hu D et al (2018) The role of mitochondria in NLRP3 inflammasome activation. Mol Immunol 103:115\u2013124. https:\/\/doi.org\/10.1016\/j.molimm.2018.09.010","journal-title":"Mol Immunol"},{"key":"2274_CR78","doi-asserted-by":"publisher","first-page":"5026","DOI":"10.1007\/s12035-020-02073-3","volume":"57","author":"S Liu","year":"2020","unstructured":"Liu S, Gao J, Zhu M et al (2020) Gut microbiota and dysbiosis in Alzheimer\u2019s disease: implications for pathogenesis and treatment. Mol Neurobiol 57:5026\u20135043. https:\/\/doi.org\/10.1007\/s12035-020-02073-3","journal-title":"Mol Neurobiol"},{"key":"2274_CR79","doi-asserted-by":"crossref","unstructured":"Liu J, Yang Y, Guo Y, et al (2021) Z-Guggulsterone attenuates cognitive deficits and reduces amyloid-\u03b2 levels in APPswe\/PS1dE9 mice by inhibiting toll-like receptor 4 pathway","DOI":"10.21203\/rs.3.rs-763008\/v1"},{"key":"2274_CR80","doi-asserted-by":"publisher","DOI":"10.1186\/s13195-024-01599-1","volume":"16","author":"H Long","year":"2024","unstructured":"Long H, Simmons A, Mayorga A et al (2024) Preclinical and first-in-human evaluation of AL002, a novel TREM2 agonistic antibody for Alzheimer\u2019s disease. Alzheimers Res Ther 16:235. https:\/\/doi.org\/10.1186\/s13195-024-01599-1","journal-title":"Alzheimers Res Ther"},{"key":"2274_CR81","doi-asserted-by":"publisher","first-page":"32145","DOI":"10.1073\/pnas.2009680117","volume":"117","author":"N Lonnemann","year":"2020","unstructured":"Lonnemann N, Hosseini S, Marchetti C et al (2020) The NLRP3 inflammasome inhibitor OLT1177 rescues cognitive impairment in a mouse model of Alzheimer\u2019s disease. Proc Natl Acad Sci U S A 117:32145\u201332154. https:\/\/doi.org\/10.1073\/pnas.2009680117","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2274_CR82","doi-asserted-by":"publisher","first-page":"650","DOI":"10.1111\/jnc.14945","volume":"155","author":"A Lu\u010di\u016bnait\u0117","year":"2020","unstructured":"Lu\u010di\u016bnait\u0117 A, McManus RM, Jankunec M et al (2020) Soluble A\u03b2 oligomers and protofibrils induce NLRP3 inflammasome activation in microglia. J Neurochem 155:650\u2013661","journal-title":"J Neurochem"},{"key":"2274_CR83","doi-asserted-by":"publisher","first-page":"896","DOI":"10.3389\/fnins.2018.00896","volume":"12","author":"WJ Lukiw","year":"2018","unstructured":"Lukiw WJ, Cong L, Jaber V, Zhao Y (2018) Microbiome-derived lipopolysaccharide (LPS) selectively inhibits neurofilament light chain (NF-L) gene expression in human neuronal-glial (HNG) cells in primary culture. Front Neurosci 12:896","journal-title":"Front Neurosci"},{"key":"2274_CR84","doi-asserted-by":"publisher","first-page":"417","DOI":"10.1146\/annurev-pharmtox-031023-125300","volume":"64","author":"Q Ma","year":"2024","unstructured":"Ma Q, Lim CS (2024) Molecular activation of NLRP3 inflammasome by particles and crystals: a continuing challenge of immunology and toxicology. Annu Rev Pharmacol Toxicol 64:417\u2013433","journal-title":"Annu Rev Pharmacol Toxicol"},{"key":"2274_CR85","doi-asserted-by":"publisher","first-page":"625","DOI":"10.1002\/dneu.22409","volume":"77","author":"CJ Maturana","year":"2017","unstructured":"Maturana CJ, Aguirre A, Saez JC (2017) High glucocorticoid levels during gestation activate the inflammasome in hippocampal oligodendrocytes of the offspring. Dev Neurobiol 77:625\u2013642","journal-title":"Dev Neurobiol"},{"key":"2274_CR86","doi-asserted-by":"publisher","DOI":"10.1007\/s12035-025-04918-1","author":"R Maurya","year":"2025","unstructured":"Maurya R, Sharma A, Naqvi S (2025) Decoding NLRP3 inflammasome activation in Alzheimer\u2019s disease: a focus on receptor dynamics. Mol Neurobiol. https:\/\/doi.org\/10.1007\/s12035-025-04918-1","journal-title":"Mol Neurobiol"},{"key":"2274_CR87","doi-asserted-by":"publisher","first-page":"453","DOI":"10.1021\/acsinfecdis.4c00641","volume":"11","author":"CR McCutcheon","year":"2025","unstructured":"McCutcheon CR, Gaddy JA, Aronoff DM et al (2025) Group B Streptococcal membrane vesicles induce proinflammatory cytokine production and are sensed in an NLRP3 inflammasome-dependent mechanism in a human macrophage-like cell line. ACS Infect Dis 11:453\u2013462","journal-title":"ACS Infect Dis"},{"key":"2274_CR88","unstructured":"Mcdonald C (2023) ZyVersa therapeutics announces article published in brain pathology addressing inflammasome signaling proteins in Alzheimer \u2018 s disease tiberend strategic advisors , Inc ."},{"key":"2274_CR89","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2024.109941","volume":"252","author":"RM McManus","year":"2024","unstructured":"McManus RM, Latz E (2024) NLRP3 inflammasome signalling in Alzheimer\u2019s disease. Neuropharmacology 252:109941. https:\/\/doi.org\/10.1016\/j.neuropharm.2024.109941","journal-title":"Neuropharmacology"},{"key":"2274_CR90","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2023.1196413","volume":"14","author":"D Melchiorri","year":"2023","unstructured":"Melchiorri D, Merlo S, Micallef B et al (2023) Alzheimer\u2019s disease and neuroinflammation: will new drugs in clinical trials pave the way to a multi-target therapy? Front Pharmacol 14:1196413. https:\/\/doi.org\/10.3389\/fphar.2023.1196413","journal-title":"Front Pharmacol"},{"key":"2274_CR91","doi-asserted-by":"publisher","unstructured":"Merighi S, Nigro M, Travagli A, et al (2022) A(2A) Adenosine receptor: a possible therapeutic target for Alzheimer\u2019s disease by regulating NLRP3 inflammasome activity? Int J Mol Sci 23:. https:\/\/doi.org\/10.3390\/ijms23095056","DOI":"10.3390\/ijms23095056"},{"key":"2274_CR92","doi-asserted-by":"publisher","DOI":"10.1002\/alz.084622","volume":"20","author":"C Mirescu","year":"2024","unstructured":"Mirescu C (2024) Characterization of the first TREM2 small molecule agonist, VG-3927, for clinical development in Alzheimer\u2019s disease. Alzheimers Dement 20:e084622","journal-title":"Alzheimers Dement"},{"key":"2274_CR93","doi-asserted-by":"publisher","DOI":"10.3390\/cells14010036","author":"E Moustakli","year":"2025","unstructured":"Moustakli E, Stavros S, Katopodis P et al (2025) Oxidative stress and the NLRP3 inflammasome: focus on female fertility and reproductive health. Cells. https:\/\/doi.org\/10.3390\/cells14010036","journal-title":"Cells"},{"key":"2274_CR94","doi-asserted-by":"publisher","first-page":"1142","DOI":"10.1016\/j.immuni.2013.05.016","volume":"38","author":"R Mu\u00f1oz-Planillo","year":"2013","unstructured":"Mu\u00f1oz-Planillo R, Kuffa P, Mart\u00ednez-Col\u00f3n G et al (2013) K+ efflux is the common trigger of NLRP3 inflammasome activation by bacterial toxins and particulate matter. Immunity 38:1142\u20131153. https:\/\/doi.org\/10.1016\/j.immuni.2013.05.016","journal-title":"Immunity"},{"key":"2274_CR95","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1007\/s12017-013-8274-6","volume":"16","author":"N Murphy","year":"2014","unstructured":"Murphy N, Grehan B, Lynch MA (2014) Glial uptake of amyloid beta induces NLRP3 inflammasome formation via cathepsin-dependent degradation of NLRP10. Neuromolecular Med 16:205\u2013215","journal-title":"Neuromolecular Med"},{"key":"2274_CR96","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1016\/j.bbi.2023.11.031","volume":"116","author":"A Naeem","year":"2024","unstructured":"Naeem A, Prakash R, Kumari N et al (2024) MCC950 reduces autophagy and improves cognitive function by inhibiting NLRP3-dependent neuroinflammation in a rat model of Alzheimer\u2019s disease. Brain Behav Immun 116:70\u201384. https:\/\/doi.org\/10.1016\/j.bbi.2023.11.031","journal-title":"Brain Behav Immun"},{"key":"2274_CR97","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2023.121983","volume":"330","author":"P Nagar","year":"2023","unstructured":"Nagar P, Sharma P, Dhapola R et al (2023) Endoplasmic reticulum stress in Alzheimer\u2019s disease: molecular mechanisms and therapeutic prospects. Life Sci 330:121983. https:\/\/doi.org\/10.1016\/j.lfs.2023.121983","journal-title":"Life Sci"},{"key":"2274_CR98","doi-asserted-by":"publisher","first-page":"158","DOI":"10.1186\/s10020-024-00917-5","volume":"30","author":"ME Noureldeen","year":"2024","unstructured":"Noureldeen ME, Shahin NN, Amin HAA et al (2024) Parthenolide ameliorates 3-nitropropionic acid-induced Huntington\u2019s disease-like aberrations via modulating NLRP3 inflammasome, reducing microglial activation and inducing astrocyte shifting. Mol Med 30:158","journal-title":"Mol Med"},{"key":"2274_CR99","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2121353119","volume":"119","author":"U Ohto","year":"2022","unstructured":"Ohto U, Kamitsukasa Y, Ishida H et al (2022) Structural basis for the oligomerization-mediated regulation of NLRP3 inflammasome activation. Proc Natl Acad Sci U S A 119:e2121353119. https:\/\/doi.org\/10.1073\/pnas.2121353119","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2274_CR100","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2025.114691","volume":"156","author":"DS Padhy","year":"2025","unstructured":"Padhy DS, Vesmaker K, Banerjee S (2025) Neuroprotective potential of tranilast in streptozotocin-induced sporadic Alzheimer\u2019s disease model targeting TXNIP-NLRP3 inflammasome pathway. Int Immunopharmacol 156:114691. https:\/\/doi.org\/10.1016\/j.intimp.2025.114691","journal-title":"Int Immunopharmacol"},{"key":"2274_CR101","doi-asserted-by":"crossref","unstructured":"Qayyum N, Haseeb M, Kim MS, Choi S (2021) Role of thioredoxin-interacting protein in diseases and its therapeutic outlook. Int. J. Mol. Sci. 22","DOI":"10.3390\/ijms22052754"},{"key":"2274_CR102","doi-asserted-by":"publisher","first-page":"1488","DOI":"10.1038\/s12276-024-01261-8","volume":"56","author":"R Ramachandran","year":"2024","unstructured":"Ramachandran R, Manan A, Kim J, Choi S (2024) NLRP3 inflammasome: a key player in the pathogenesis of life-style disorders. Exp Mol Med 56:1488\u20131500. https:\/\/doi.org\/10.1038\/s12276-024-01261-8","journal-title":"Exp Mol Med"},{"key":"2274_CR103","doi-asserted-by":"publisher","DOI":"10.1038\/s41398-023-02557-5","volume":"13","author":"K Recourt","year":"2023","unstructured":"Recourt K, de Boer P, van der Ark P et al (2023) Characterization of the central nervous system penetrant and selective purine P2X7 receptor antagonist JNJ-54175446 in patients with major depressive disorder. Transl Psychiatry 13:266","journal-title":"Transl Psychiatry"},{"key":"2274_CR104","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2309579121","volume":"121","author":"P Rozario","year":"2024","unstructured":"Rozario P, Pinilla M, Gorse L et al (2024) Mechanistic basis for potassium efflux\u2013driven activation of the human NLRP1 inflammasome. Proc Natl Acad Sci U S A 121:e2309579121","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2274_CR105","doi-asserted-by":"publisher","DOI":"10.1186\/s13024-020-00396-2","volume":"15","author":"Z Ruan","year":"2020","unstructured":"Ruan Z, Delpech J-C, Venkatesan Kalavai S et al (2020) P2RX7 inhibitor suppresses exosome secretion and disease phenotype in P301S tau transgenic mice. Mol Neurodegener 15:47. https:\/\/doi.org\/10.1186\/s13024-020-00396-2","journal-title":"Mol Neurodegener"},{"key":"2274_CR106","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s13024-016-0088-1","volume":"11","author":"M Saresella","year":"2016","unstructured":"Saresella M, La Rosa F, Piancone F et al (2016) The NLRP3 and NLRP1 inflammasomes are activated in Alzheimer\u2019s disease. Mol Neurodegener 11:1\u201314","journal-title":"Mol Neurodegener"},{"key":"2274_CR107","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1074\/jbc.M110.139048","volume":"286","author":"C Schorn","year":"2011","unstructured":"Schorn C, Frey B, Lauber K et al (2011) Sodium overload and water influx activate the NALP3 inflammasome. J Biol Chem 286:35\u201341","journal-title":"J Biol Chem"},{"key":"2274_CR108","unstructured":"Sekhon P, Singh R, Song A (2022) Investigating the role of calcium ion mobilization in NLRP3 inflammasome activation of J774A. 1 macrophages and optimizing cell morphology and IL-1\u03b2 quantification protocols. Undergrad J Exp Microbiol Immunol 27:"},{"key":"2274_CR109","doi-asserted-by":"publisher","first-page":"624","DOI":"10.1080\/00207454.2016.1212854","volume":"127","author":"T Shabab","year":"2017","unstructured":"Shabab T, Khanabdali R, Moghadamtousi SZ et al (2017) Neuroinflammation pathways: a general review. Int J Neurosci 127:624\u2013633. https:\/\/doi.org\/10.1080\/00207454.2016.1212854","journal-title":"Int J Neurosci"},{"key":"2274_CR110","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1007\/s10753-022-01730-0","volume":"46","author":"B Sharma","year":"2023","unstructured":"Sharma B, Satija G, Madan A et al (2023) Role of NLRP3 inflammasome and its inhibitors as emerging therapeutic drug candidate for Alzheimer\u2019s disease: a review of mechanism of activation, regulation, and inhibition. Inflammation 46:56\u201387. https:\/\/doi.org\/10.1007\/s10753-022-01730-0","journal-title":"Inflammation"},{"key":"2274_CR111","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1016\/j.jneuroim.2013.04.016","volume":"260","author":"F Shi","year":"2013","unstructured":"Shi F, Yang Y, Kouadir M et al (2013) Inhibition of phagocytosis and lysosomal acidification suppresses neurotoxic prion peptide-induced NALP3 inflammasome activation in BV2 microglia. J Neuroimmunol 260:121\u2013125","journal-title":"J Neuroimmunol"},{"key":"2274_CR112","doi-asserted-by":"publisher","first-page":"665","DOI":"10.1002\/eji.201545855","volume":"46","author":"S Shi","year":"2016","unstructured":"Shi S, Liang D, Chen Y et al (2016) Gx-50 reduces \u03b2-amyloid-induced TNF-\u03b1, IL-1\u03b2, NO, and PGE2 expression and inhibits NF-\u03baB signaling in a mouse model of Alzheimer\u2019s disease. Eur J Immunol 46:665\u2013676","journal-title":"Eur J Immunol"},{"key":"2274_CR113","doi-asserted-by":"publisher","DOI":"10.1177\/20587392211058615","volume":"19","author":"Q Shi","year":"2021","unstructured":"Shi Q, Zheng Y-Y, Wang L et al (2021) Curcumin suppresses neuroinflammation to protect neurons by preventing NLRP3 inflammasome activation. Eur J Inflamm 19:20587392211058616. https:\/\/doi.org\/10.1177\/20587392211058615","journal-title":"Eur J Inflamm"},{"key":"2274_CR114","doi-asserted-by":"publisher","DOI":"10.1111\/imr.13365","author":"DC Shippy","year":"2024","unstructured":"Shippy DC, Evered AH, Ulland TK (2024) Ketone body metabolism and the NLRP3 inflammasome in Alzheimer\u2019s disease. Immunol Rev. https:\/\/doi.org\/10.1111\/imr.13365","journal-title":"Immunol Rev"},{"key":"2274_CR115","doi-asserted-by":"crossref","unstructured":"Shippy DC, Wilhelm C, Viharkumar PA, et al (2020) \u03b2 -Hydroxybutyrate inhibits inflammasome activation to attenuate Alzheimer\u2018s disease pathology. 5:1\u201312","DOI":"10.1186\/s12974-020-01948-5"},{"key":"2274_CR116","doi-asserted-by":"publisher","unstructured":"Shukla PK, Delotterie DF, Xiao J, et al (2021) Alterations in the Gut-Microbial-Inflammasome-Brain Axis in a Mouse Model of Alzheimer\u2019s Disease. Cells 10:. https:\/\/doi.org\/10.3390\/cells10040779","DOI":"10.3390\/cells10040779"},{"key":"2274_CR117","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2025.1550333","volume":"19","author":"C Singh Solorzano","year":"2025","unstructured":"Singh Solorzano C, Festari C, Mirabelli P et al (2025) Association between cognitive functioning and microbiota-gut-brain axis mediators in a memory clinic population. Front Cell Neurosci 19:1550333","journal-title":"Front Cell Neurosci"},{"key":"2274_CR118","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1016\/j.molcel.2017.08.017","volume":"68","author":"N Song","year":"2017","unstructured":"Song N, Liu Z-S, Xue W et al (2017) NLRP3 phosphorylation is an essential priming event for inflammasome activation. Mol Cell 68:185\u2013197","journal-title":"Mol Cell"},{"key":"2274_CR119","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-021-04420-1","volume":"12","author":"PM Soriano-Teruel","year":"2021","unstructured":"Soriano-Teruel PM, Garc\u00eda\u2011La\u00ednez G, Marco-Salvador M et al (2021) Identification of an ASC oligomerization inhibitor for the treatment of inflammatory diseases. Cell Death Dis 12:1155. https:\/\/doi.org\/10.1038\/s41419-021-04420-1","journal-title":"Cell Death Dis"},{"key":"2274_CR120","doi-asserted-by":"publisher","DOI":"10.1186\/s10194-023-01707-w","volume":"25","author":"S Sun","year":"2024","unstructured":"Sun S, Fan Z, Liu X et al (2024) Microglia TREM1-mediated neuroinflammation contributes to central sensitization via the NF-\u03baB pathway in a chronic migraine model. J Headache Pain 25:3. https:\/\/doi.org\/10.1186\/s10194-023-01707-w","journal-title":"J Headache Pain"},{"key":"2274_CR121","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1002\/eji.201848013","volume":"50","author":"T Suzuki","year":"2020","unstructured":"Suzuki T, Kohyama K, Moriyama K et al (2020) Extracellular ADP augments microglial inflammasome and NF-\u03baB activation via the P2Y12 receptor. Eur J Immunol 50:205\u2013219. https:\/\/doi.org\/10.1002\/eji.201848013","journal-title":"Eur J Immunol"},{"key":"2274_CR122","doi-asserted-by":"publisher","first-page":"477","DOI":"10.1038\/s41577-019-0165-0","volume":"19","author":"KV Swanson","year":"2019","unstructured":"Swanson KV, Deng M, Ting JP-Y (2019) The NLRP3 inflammasome: molecular activation and regulation to therapeutics. Nat Rev Immunol 19:477\u2013489. https:\/\/doi.org\/10.1038\/s41577-019-0165-0","journal-title":"Nat Rev Immunol"},{"key":"2274_CR123","doi-asserted-by":"publisher","first-page":"86","DOI":"10.1016\/j.immuni.2023.12.002","volume":"57","author":"E Tagliatti","year":"2024","unstructured":"Tagliatti E, Desiato G, Mancinelli S et al (2024) Trem2 expression in microglia is required to maintain normal neuronal bioenergetics during development. Immunity 57:86\u2013105","journal-title":"Immunity"},{"key":"2274_CR124","doi-asserted-by":"crossref","unstructured":"Tang H, Harte M (2021) Investigating Markers of the NLRP3 Inflammasome Pathway in Alzheimer\u2019s Disease: A Human Post-Mortem Study. Genes (Basel). 12","DOI":"10.3390\/genes12111753"},{"key":"2274_CR125","doi-asserted-by":"publisher","first-page":"1005","DOI":"10.1111\/bph.17373","volume":"182","author":"G Tao","year":"2025","unstructured":"Tao G, Wang X, Wang J et al (2025) Dihydro-resveratrol ameliorates NLRP3 inflammasome-mediated neuroinflammation via Bnip3-dependent mitophagy in Alzheimer\u2019s disease. Br J Pharmacol 182:1005\u20131024","journal-title":"Br J Pharmacol"},{"key":"2274_CR126","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s10753-022-01721-1","volume":"46","author":"S Thakur","year":"2023","unstructured":"Thakur S, Dhapola R, Sarma P et al (2023) Neuroinflammation in Alzheimer\u2019s disease: current progress in molecular signaling and therapeutics. Inflammation 46:1\u201317. https:\/\/doi.org\/10.1007\/s10753-022-01721-1","journal-title":"Inflammation"},{"key":"2274_CR127","doi-asserted-by":"publisher","first-page":"939","DOI":"10.3233\/JAD-210268","volume":"83","author":"M Van Zeller","year":"2021","unstructured":"Van Zeller M, Dias D, Sebasti\u00e3o AM, Valente CA (2021) NLRP3 inflammasome: A starring role in amyloid-\u03b2- and Tau-driven pathological events in Alzheimer\u2019s disease. J Alzheimers Dis 83:939\u2013961. https:\/\/doi.org\/10.3233\/JAD-210268","journal-title":"J Alzheimers Dis"},{"key":"2274_CR128","doi-asserted-by":"publisher","first-page":"355","DOI":"10.1038\/nature25158","volume":"552","author":"C Venegas","year":"2017","unstructured":"Venegas C, Kumar S, Franklin BS et al (2017) Microglia-derived ASC specks cross-seed amyloid-\u03b2 in Alzheimer\u2019s disease. Nature 552:355\u2013361","journal-title":"Nature"},{"key":"2274_CR129","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1016\/j.neurobiolaging.2017.03.016","volume":"55","author":"H-Y Wang","year":"2017","unstructured":"Wang H-Y, Lee K-C, Pei Z et al (2017a) PTI-125 binds and reverses an altered conformation of filamin A to reduce Alzheimer\u2019s disease pathogenesis. Neurobiol Aging 55:99\u2013114. https:\/\/doi.org\/10.1016\/j.neurobiolaging.2017.03.016","journal-title":"Neurobiol Aging"},{"key":"2274_CR130","doi-asserted-by":"publisher","first-page":"768","DOI":"10.3892\/mmr.2016.6070","volume":"15","author":"X Wang","year":"2017","unstructured":"Wang X, Xie X, Luo X et al (2017b) Inhibiting purinergic P2X7 receptors with the antagonist brilliant blue G is neuroprotective in an intranigral lipopolysaccharide animal model of Parkinson\u2019s disease. Mol Med Rep 15:768\u2013776. https:\/\/doi.org\/10.3892\/mmr.2016.6070","journal-title":"Mol Med Rep"},{"key":"2274_CR131","doi-asserted-by":"publisher","first-page":"3957","DOI":"10.3892\/mmr.2018.9349","volume":"18","author":"Z Wang","year":"2018","unstructured":"Wang Z, Zhou W, Dong H et al (2018) Dexmedetomidine pretreatment inhibits cerebral ischemia\/reperfusion-induced neuroinflammation via activation of AMPK. Mol Med Rep 18:3957\u20133964. https:\/\/doi.org\/10.3892\/mmr.2018.9349","journal-title":"Mol Med Rep"},{"key":"2274_CR132","doi-asserted-by":"crossref","unstructured":"Wang W, Huang F, Jiang W, et al (2020) Brilliant blue G attenuates neuro\u2011inflammation via regulating MAPKs and NF\u2011&kappa;B signaling pathways in lipopolysaccharide\u2011induced BV2 microglia cells. In: Exp Ther Med. Department of Rehabilitation, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, Jiangsu 221002, P.R. China Department of Neurology, The Affiliated Hospital of Jiangsu University, Zhenjiang, Jiangsu 212001, P.R. China Department of Neurology, T, p 116","DOI":"10.3892\/etm.2020.9244"},{"key":"2274_CR133","doi-asserted-by":"publisher","unstructured":"Wang W, Dernst A, Martin B, et al (2024) Butyrate and propionate are microbial danger signals that activate the NLRP3 inflammasome in human macrophages upon TLR stimulation. Cell Rep 43. https:\/\/doi.org\/10.1016\/j.celrep.2024.114736","DOI":"10.1016\/j.celrep.2024.114736"},{"key":"2274_CR134","doi-asserted-by":"publisher","first-page":"3769","DOI":"10.1007\/s00018-017-2550-9","volume":"74","author":"S Westfall","year":"2017","unstructured":"Westfall S, Lomis N, Kahouli I et al (2017) Microbiome, probiotics and neurodegenerative diseases: deciphering the gut brain axis. Cell Mol Life Sci 74:3769\u20133787","journal-title":"Cell Mol Life Sci"},{"key":"2274_CR135","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2023.110181","volume":"119","author":"J Wongpun","year":"2023","unstructured":"Wongpun J, Chanmanee T, Tocharus J, Chokchaisiri R (2023) The potential effects of festidinol treatment against the NLRP3 inflammasome and pyroptosis in D-galactose and aluminum chloride \u2013 induced Alzheimer \u2019 s-like pathology in mouse brain. Int Immunopharmacol 119:110181. https:\/\/doi.org\/10.1016\/j.intimp.2023.110181","journal-title":"Int Immunopharmacol"},{"key":"2274_CR136","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2020.101202","volume":"65","author":"A-G Wu","year":"2021","unstructured":"Wu A-G, Zhou X-G, Qiao G et al (2021a) Targeting microglial autophagic degradation in NLRP3 inflammasome-mediated neurodegenerative diseases. Ageing Res Rev 65:101202","journal-title":"Ageing Res Rev"},{"key":"2274_CR137","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3389\/fimmu.2021.766178","volume":"12","author":"X Wu","year":"2021","unstructured":"Wu X, Zeng H, Xu C et al (2021b) TREM1 regulates neuroin fl ammatory injury by modulate proin fl ammatory subtype transition of microglia and formation of neutrophil extracellular traps via interaction with SYK in experimental subarachnoid hemorrhage. Front Immunol 12:1\u201315. https:\/\/doi.org\/10.3389\/fimmu.2021.766178","journal-title":"Front Immunol"},{"key":"2274_CR138","doi-asserted-by":"publisher","DOI":"10.1155\/2022\/7924199","volume":"2022","author":"L Wu","year":"2022","unstructured":"Wu L, Xian X, Xu G et al (2022) Toll-Like Receptor 4: a promising therapeutic target for Alzheimer\u2019s disease. Mediators Inflamm 2022:7924199. https:\/\/doi.org\/10.1155\/2022\/7924199","journal-title":"Mediators Inflamm"},{"key":"2274_CR139","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.609441","volume":"11","author":"Z Xu","year":"2020","unstructured":"Xu Z, Chen Z, Wu X et al (2020) Distinct molecular mechanisms underlying potassium efflux for NLRP3 inflammasome activation. Front Immunol 11:609441","journal-title":"Front Immunol"},{"key":"2274_CR140","doi-asserted-by":"publisher","first-page":"1397","DOI":"10.1007\/s11010-022-04602-1","volume":"478","author":"X Xu","year":"2023","unstructured":"Xu X, Wu X, Yue G et al (2023) The role of Nod-like receptor protein 3 inflammasome activated by ion channels in multiple diseases. Mol Cell Biochem 478:1397\u20131410. https:\/\/doi.org\/10.1007\/s11010-022-04602-1","journal-title":"Mol Cell Biochem"},{"key":"2274_CR141","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-019-1413-8","volume":"10","author":"Y Yang","year":"2019","unstructured":"Yang Y, Wang H, Kouadir M et al (2019b) Recent advances in the mechanisms of NLRP3 inflammasome activation and its inhibitors. Cell Death Dis 10:128. https:\/\/doi.org\/10.1038\/s41419-019-1413-8","journal-title":"Cell Death Dis"},{"key":"2274_CR142","doi-asserted-by":"publisher","first-page":"724","DOI":"10.3389\/fimmu.2020.00724","volume":"11","author":"J Yang","year":"2020","unstructured":"Yang J, Wise L, Fukuchi K-I (2020) TLR4 cross-talk with NLRP3 inflammasome and complement signaling pathways in Alzheimer\u2019s disease. Front Immunol 11:724. https:\/\/doi.org\/10.3389\/fimmu.2020.00724","journal-title":"Front Immunol"},{"key":"2274_CR143","doi-asserted-by":"publisher","first-page":"1077222","DOI":"10.3389\/fphar.2022.1077222","volume":"13","author":"Z Yang","year":"2022","unstructured":"Yang Z, Liu J, Wei S et al (2022) A novel strategy for bioactive natural products targeting NLRP3 inflammasome in Alzheimer\u2019s disease. Front Pharmacol 13:1077222. https:\/\/doi.org\/10.3389\/fphar.2022.1077222","journal-title":"Front Pharmacol"},{"key":"2274_CR144","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2022.148206","volume":"1801","author":"Y Yang","year":"2023","unstructured":"Yang Y, Zhang J, Yang C et al (2023) Sulforaphane attenuates microglia-mediated neuronal damage by down-regulating the ROS\/autophagy\/NLRP3 signal axis in fibrillar A\u03b2-activated microglia. Brain Res 1801:148206. https:\/\/doi.org\/10.1016\/j.brainres.2022.148206","journal-title":"Brain Res"},{"key":"2274_CR145","doi-asserted-by":"publisher","unstructured":"Yang Y, Wang H, Kouadir M, et al (2019a) Recent advances in the mechanisms of NLRP3 inflammasome activation and its inhibitors. Cell Death Dis 10. https:\/\/doi.org\/10.1038\/s41419-019-1413-8","DOI":"10.1038\/s41419-019-1413-8"},{"key":"2274_CR146","doi-asserted-by":"publisher","first-page":"1977","DOI":"10.1007\/s12035-017-0467-9","volume":"55","author":"J Yin","year":"2018","unstructured":"Yin J, Zhao F, Chojnacki JE et al (2018) NLRP3 inflammasome inhibitor ameliorates amyloid pathology in a mouse model of Alzheimer\u2019s disease. Mol Neurobiol 55:1977\u20131987. https:\/\/doi.org\/10.1007\/s12035-017-0467-9","journal-title":"Mol Neurobiol"},{"key":"2274_CR147","doi-asserted-by":"publisher","first-page":"2560","DOI":"10.1007\/s11064-020-03121-z","volume":"45","author":"Y Zhang","year":"2020","unstructured":"Zhang Y, Zhao Y, Zhang J, Yang G (2020) Mechanisms of NLRP3 inflammasome activation: its role in the treatment of Alzheimer\u2019s Disease. Neurochem Res 45:2560\u20132572. https:\/\/doi.org\/10.1007\/s11064-020-03121-z","journal-title":"Neurochem Res"},{"key":"2274_CR148","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2021.136206","volume":"764","author":"Y Zhang","year":"2021","unstructured":"Zhang Y, Zhao Y, Zhang J et al (2021) Ginkgolide B inhibits NLRP3 inflammasome activation and promotes microglial M2 polarization in A\u03b21-42-induced microglia cells. Neurosci Lett 764:136206","journal-title":"Neurosci Lett"},{"key":"2274_CR149","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1186\/s13041-022-00969-w","volume":"15","author":"C Zhang","year":"2022","unstructured":"Zhang C, Kan X, Zhang B et al (2022a) The role of triggering receptor expressed on myeloid cells-1 (TREM-1) in central nervous system diseases. Mol Brain 15:84. https:\/\/doi.org\/10.1186\/s13041-022-00969-w","journal-title":"Mol Brain"},{"key":"2274_CR150","doi-asserted-by":"publisher","first-page":"8645714","DOI":"10.1155\/2022\/8645714","volume":"2022","author":"Y Zhang","year":"2022","unstructured":"Zhang Y, Xing C-J, Liu X et al (2022b) Thioredoxin-interacting protein (TXNIP) knockdown protects against sepsis-induced brain injury and cognitive decline in mice by suppressing oxidative stress and neuroinflammation. Oxid Med Cell Longev 2022:8645714","journal-title":"Oxid Med Cell Longev"},{"key":"2274_CR151","doi-asserted-by":"publisher","first-page":"4181","DOI":"10.7150\/ijbs.85158","volume":"19","author":"J Zhang","year":"2023","unstructured":"Zhang J, Zhang R, Li W et al (2023) I\u03baB kinase \u03b2 (IKK\u03b2): structure, transduction mechanism, biological function, and discovery of its inhibitors. Int J Biol Sci 19:4181","journal-title":"Int J Biol Sci"},{"key":"2274_CR152","doi-asserted-by":"publisher","first-page":"10923","DOI":"10.18632\/aging.102495","volume":"11","author":"X-Y Zheng","year":"2019","unstructured":"Zheng X-Y, Lv Y-D, Jin F-Y et al (2019) Kainic acid hyperphosphorylates tau via inflammasome activation in MAPT transgenic mice. Aging (Albany NY) 11:10923\u201310938. https:\/\/doi.org\/10.18632\/aging.102495","journal-title":"Aging (Albany NY)"},{"key":"2274_CR153","doi-asserted-by":"publisher","first-page":"911","DOI":"10.3233\/JAD-240012","volume":"99","author":"M Zhu","year":"2024","unstructured":"Zhu M, Liu Y, Chen C et al (2024) TLR4\/Rac1\/NLRP3 pathway mediates Amyloid-\u03b2-induced neuroinflammation in Alzheimer\u2019s Disease. J Alzheimers Dis 99:911\u2013925. https:\/\/doi.org\/10.3233\/JAD-240012","journal-title":"J Alzheimers Dis"},{"key":"2274_CR154","doi-asserted-by":"publisher","unstructured":"Zhu K, Jin X, Chi Z, et al (2021) Priming of NLRP3 in fl ammasome activation by Msn kinase MINK1 in macrophages. https:\/\/doi.org\/10.1038\/s41423-021-00761-1","DOI":"10.1038\/s41423-021-00761-1"},{"key":"2274_CR155","doi-asserted-by":"publisher","first-page":"7296","DOI":"10.1007\/s12035-025-04715-w","volume":"62","author":"R Zu","year":"2025","unstructured":"Zu R, Lu H, Liu W et al (2025) Research progress in the molecular mechanism of NLRP3 inflammasome in Alzheimer\u2019s Disease and regulation by natural plant products. Mol Neurobiol 62:7296\u20137312. https:\/\/doi.org\/10.1007\/s12035-025-04715-w","journal-title":"Mol Neurobiol"}],"container-title":["Inflammopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10787-026-02274-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10787-026-02274-7","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10787-026-02274-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T07:16:59Z","timestamp":1784704619000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10787-026-02274-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,2]]},"references-count":155,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2026,7]]}},"alternative-id":["2274"],"URL":"https:\/\/doi.org\/10.1007\/s10787-026-02274-7","relation":{},"ISSN":["0925-4692","1568-5608"],"issn-type":[{"value":"0925-4692","type":"print"},{"value":"1568-5608","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,2]]},"assertion":[{"value":"9 October 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 May 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 June 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare that the manuscript work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. The authors declare no competing interests.","order":1,"name":"Ethics","label":"Conflict of interest","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Yes.","order":2,"name":"Ethics","label":"Ethical approval","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":3,"name":"Ethics","label":"Consent to participate","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":4,"name":"Ethics","label":"Consent for publication","group":{"name":"EthicsHeading","label":"Declarations"}}]}}