{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,11]],"date-time":"2026-10-11T19:03:51Z","timestamp":1791745431968,"version":"4.3.4"},"reference-count":61,"publisher":"Springer Science and Business Media LLC","issue":"7","license":[{"start":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T00:00:00Z","timestamp":1781481600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T00:00:00Z","timestamp":1781481600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Inflammopharmacol"],"published-print":{"date-parts":[[2026,7]]},"DOI":"10.1007\/s10787-026-02291-6","type":"journal-article","created":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T03:17:35Z","timestamp":1781493455000},"page":"4537-4550","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Epigallocatechin-3-gallate (EGCG) as a molecular chaperone and network rebalancer in neurodegenerative diseases"],"prefix":"10.1007","volume":"34","author":[{"given":"Husni","family":"Farah","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Media Hamed","family":"Ahmed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaker","family":"Al-Hasnaawei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Malathi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Swati","family":"Mishra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anima","family":"Nanda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vimal","family":"Arora","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashish Singh","family":"Chauhan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,6,15]]},"reference":[{"key":"2291_CR1","unstructured":"Aljoudi S, Chang-gonzalez A, Durie A, Dayna C, Deol PH, Deossa RAO, Esposto J (2021) Protein society diversity award winners"},{"key":"2291_CR2","first-page":"101930","volume":"41","author":"FG BABAEI","year":"2025","unstructured":"Babaei FG, Saburi E, Forouzanfar F, Asgari M, Keshavarzi Z, Hajali V (2025) Effect of epigallocatechin-3-gallate (EGCG) on cognitive functioning and the expression of APP and BDNF in the hippocampus of rats with streptozotocin-induced Alzheimer-like disease. Biochem Biophys Rep 41:101930","journal-title":"Biochem Biophys Rep"},{"key":"2291_CR3","doi-asserted-by":"publisher","first-page":"982","DOI":"10.3390\/ph14100982","volume":"14","author":"JM BRIMSON","year":"2021","unstructured":"Brimson JM, Malar P, Thitilertdecha DS, Kabra P, Tencomnao AT, Prasansuklab A (2021) Plant polyphenols for aging health: implication from their autophagy modulating properties in age-associated diseases. Pharmaceuticals 14:982","journal-title":"Pharmaceuticals"},{"key":"2291_CR4","doi-asserted-by":"publisher","first-page":"654","DOI":"10.3390\/molecules30030654","volume":"30","author":"L CAPASSO","year":"2025","unstructured":"Capasso L, De Masi L, Sirignano C, Maresca V, Basile A, Nebbioso A, Rigano D, Bontempo P (2025) Epigallocatechin gallate (EGCG): pharmacological properties, biological activities and therapeutic potential. Molecules 30:654","journal-title":"Molecules"},{"key":"2291_CR5","doi-asserted-by":"publisher","first-page":"9250066","DOI":"10.26599\/FSHW.2024.9250066","volume":"14","author":"B CHANG","year":"2025","unstructured":"Chang B, Jiang Y, Feng C, Li B, Mei J, Niu C (2025) Effect of purine diet on prognosis of deep brain stimulation for Parkinson\u2019s disease. Food Sci Hum Wellness 14:9250066","journal-title":"Food Sci Hum Wellness"},{"key":"2291_CR6","doi-asserted-by":"publisher","first-page":"154887","DOI":"10.1016\/j.phymed.2023.154887","volume":"126","author":"X CHENG","year":"2024","unstructured":"Cheng X, Li H, Zhao H, Liu D, Zhu Z, Zhang LZ, Peng W (2024) Quercetin: a promising therapy for diabetic encephalopathy through inhibition of hippocampal ferroptosis. Phytomedicine 126:154887","journal-title":"Phytomedicine"},{"key":"2291_CR7","unstructured":"Dubreuil C (2022) Glycine-assisted regeneration of the antioxidant activity of (+)-catechin and its derivatives. McGill University (Canada)"},{"key":"2291_CR8","unstructured":"Elbakary B (2021) The role of phytochemicals in modulating breast cancer resistance protein at the blood-brain barrier and the blood-tumour barrier. Aston University"},{"key":"2291_CR9","doi-asserted-by":"publisher","first-page":"621","DOI":"10.1080\/17435889.2025.2462521","volume":"20","author":"Z ESMAEILI","year":"2025","unstructured":"Esmaeili Z, Shavali Gilani P, Khosravani M, Motamedi M, Maleknejad S, Adabi M, Sadighara P (2025) Nanotechnology-driven EGCG: bridging antioxidant and therapeutic roles in metabolic and cancer pathways. Nanomedicine 20:621\u2013636","journal-title":"Nanomedicine"},{"key":"2291_CR10","unstructured":"Ferguson D (2025) Integrative design of ADAMTS partial agonists within a multi-hallmark therapeutic framework. The beginning of paving the way toward a functional cure for neurodegenerative disorders"},{"key":"2291_CR11","doi-asserted-by":"publisher","first-page":"4414","DOI":"10.1021\/acsbiomaterials.0c00188","volume":"6","author":"L FERNANDES","year":"2020","unstructured":"Fernandes L, Pereira-neves M, Azevedo A, Foguel Epara\u00fajoj D, Palhano FL (2020) Green tea polyphenol microparticles based on the oxidative coupling of EGCG inhibit amyloid aggregation\/cytotoxicity and serve as a platform for drug delivery. ACS Biomaterials Sci Eng 6:4414\u20134423","journal-title":"ACS Biomaterials Sci Eng"},{"key":"2291_CR12","doi-asserted-by":"publisher","first-page":"767","DOI":"10.3390\/biom11050767","volume":"11","author":"PB GONCALVES","year":"2021","unstructured":"Goncalves PB, Sodero ACR, Cordeiro Y (2021) Green tea epigallocatechin-3-gallate (EGCG) targeting protein misfolding in drug discovery for neurodegenerative diseases. Biomolecules 11:767","journal-title":"Biomolecules"},{"key":"2291_CR13","doi-asserted-by":"publisher","first-page":"1405","DOI":"10.1080\/10286020.2024.2371040","volume":"26","author":"Z HUI","year":"2024","unstructured":"Hui Z, Lai-Fa W, Xue-Qin W, Ling D, Bin-Sheng H, Li J-M (2024) Mechanisms and therapeutic potential of chinonin in nervous system diseases. J Asian Nat Prod Res 26:1405\u20131420","journal-title":"J Asian Nat Prod Res"},{"key":"2291_CR14","doi-asserted-by":"crossref","unstructured":"Jeyabalan JB, Veintramuthu Pandiav, Dhanasekaran Ssivasamyr M, Justin A (2025) Converging pathologies in neurodegeneration: the mechanistic interplay between \u03b1-Synuclein and Tau in Alzheimer\u2019s and Parkinson\u2019s. Neurol Sci, 1\u201311","DOI":"10.1007\/s10072-025-08421-2"},{"key":"2291_CR15","unstructured":"Kaur G (2020) Nanoparticles based drug delivery platform to improve oral uptake for the treatment of Alzheimer\u2019s disease"},{"key":"2291_CR16","doi-asserted-by":"publisher","first-page":"920128","DOI":"10.1155\/2013\/920128","volume":"2013","author":"JJ Kim","year":"2013","unstructured":"Kim JJ, Tan Y, Xiao L, Sun Y-L, Qu X (2013) Green tea polyphenol epigallocatechin-3\u2010gallate enhance glycogen synthesis and inhibit lipogenesis in hepatocytes. BioMed Res Int, 2013:920128","journal-title":"BioMed Res Int"},{"key":"2291_CR17","doi-asserted-by":"publisher","first-page":"1425839","DOI":"10.3389\/fnut.2024.1425839","volume":"11","author":"S LI","year":"2024","unstructured":"Li S, Wang Z, Liu G, Chen M (2024) Neurodegenerative diseases and catechins:(\u2013)-epigallocatechin-3-gallate is a modulator of chronic neuroinflammation and oxidative stress. Front Nutr 11:1425839","journal-title":"Front Nutr"},{"key":"2291_CR18","doi-asserted-by":"publisher","first-page":"3274","DOI":"10.3390\/ijms20133274","volume":"20","author":"F LIMANAQI","year":"2019","unstructured":"Limanaqi F, Biagioni F, Busceti CL, Ryskalin L, Polzella M, Frati A, Fornai F (2019) Phytochemicals bridging autophagy induction and alpha-synuclein degradation in parkinsonism. Int J Mol Sci 20:3274","journal-title":"Int J Mol Sci"},{"key":"2291_CR19","doi-asserted-by":"publisher","first-page":"9205","DOI":"10.3390\/ijms24119205","volume":"24","author":"S LIU","year":"2023","unstructured":"Liu S, Jia Y, Meng S, Luo Y, Yang Q, Pan Z (2023) Mechanisms of and potential medications for oxidative stress in ovarian granulosa cells: a review. Int J Mol Sci 24:9205","journal-title":"Int J Mol Sci"},{"key":"2291_CR20","doi-asserted-by":"crossref","unstructured":"Liu Y, Chen Z-J, Fei Y, Yu X, Chen G (2025) Investigating the therapeutic potential of epigallocatechin gallate (EGCG) for chronic pain management: Mechanisms, applications, and future perspectives. Fitoterapia, 106646","DOI":"10.1016\/j.fitote.2025.106646"},{"key":"2291_CR22","doi-asserted-by":"publisher","first-page":"395","DOI":"10.3389\/fphar.2019.00395","volume":"10","author":"H LUO","year":"2019","unstructured":"Luo H, Xiang Y, Qu X, Liu H, Liu C, Li G, Han L, Qin X (2019) Apelin-13 suppresses neuroinflammation against cognitive deficit in a streptozotocin-induced rat model of Alzheimer\u2019s disease through activation of BDNF-TrkB signaling pathway. Front Pharmacol 10:395","journal-title":"Front Pharmacol"},{"key":"2291_CR21","doi-asserted-by":"publisher","first-page":"0537","DOI":"10.34133\/research.0537","volume":"7","author":"F LUO","year":"2024","unstructured":"Luo F, Guo Liul, Liang M, Chen J, Shi L, Cheng Xliuh Y, Du Y (2024) Deciphering and targeting the ESR2\u2013miR-10a-5p\u2013BDNF axis in the prefrontal cortex: advancing postpartum depression understanding and therapeutics. Research 7:0537","journal-title":"Research"},{"key":"2291_CR23","doi-asserted-by":"publisher","first-page":"e14189","DOI":"10.1111\/jfbc.14189","volume":"46","author":"S Mehmood","year":"2022","unstructured":"Mehmood S, Maqsood M, Mahtab N, Khan MI, Sahar A, Zaib S, Gul S (2022) Epigallocatechin gallate: phytochemistry, bioavailability, utilization challenges, and strategies. J Food Biochem, 46, e14189","journal-title":"J Food Biochem"},{"key":"2291_CR24","doi-asserted-by":"publisher","first-page":"340","DOI":"10.3390\/ijms24010340","volume":"24","author":"D MOKRA","year":"2022","unstructured":"Mokra D, Joskova M, Mokry J (2022) Therapeutic effects of green tea polyphenol (\u2013)-Epigallocatechin-3-Gallate (EGCG) in relation to molecular pathways controlling inflammation, oxidative stress, and apoptosis. Int J Mol Sci 24:340","journal-title":"Int J Mol Sci"},{"key":"2291_CR25","doi-asserted-by":"publisher","first-page":"2140001","DOI":"10.1142\/S2251237321400013","volume":"9","author":"A MONDAL","year":"2021","unstructured":"Mondal A, Khan Meh, Ghosh P, De P (2021) Future direction of designing antioxidant polymers in modulating protein aggregation process. J Mol Eng Mater 9:2140001","journal-title":"J Mol Eng Mater"},{"key":"2291_CR26","doi-asserted-by":"publisher","first-page":"1271","DOI":"10.1016\/j.fct.2007.10.006","volume":"46","author":"H-K NA","year":"2008","unstructured":"Na H-K, Surh Y-J (2008) Modulation of Nrf2-mediated antioxidant and detoxifying enzyme induction by the green tea polyphenol EGCG. Food Chem Toxicol 46:1271\u20131278","journal-title":"Food Chem Toxicol"},{"key":"2291_CR27","doi-asserted-by":"publisher","first-page":"1193","DOI":"10.3390\/antiox14101193","volume":"14","author":"OC OWEGIE","year":"2025","unstructured":"Owegie OC, Davizon-Castillo Kennedyqp P, Yang M (2025) Thiol isomerases: enzymatic mechanisms, models of oxidation, and antagonism by galloylated polyphenols. Antioxidants 14:1193","journal-title":"Antioxidants"},{"key":"2291_CR28","doi-asserted-by":"publisher","first-page":"3177","DOI":"10.3390\/molecules30153177","volume":"30","author":"N PARVIN","year":"2025","unstructured":"Parvin N, Aslam M, Joo SW, Mandal TK (2025) Nano-phytomedicine: harnessing plant-derived phytochemicals in nanocarriers for targeted human health applications. Molecules 30:3177","journal-title":"Molecules"},{"key":"2291_CR29","first-page":"217","volume":"59","author":"S PATRA","year":"2008","unstructured":"Patra S, Rizzi F, Silva A, Rugina D, Bettuzzi S (2008) Molecular targets of (-)-epigallocatechin-3-gallate (EGCG): specificity and interaction with membrane lipid rafts. J Physiol Pharmacol 59:217\u2013235","journal-title":"J Physiol Pharmacol"},{"key":"2291_CR30","doi-asserted-by":"publisher","first-page":"371","DOI":"10.3390\/biom12030371","volume":"12","author":"A PAYNE","year":"2022","unstructured":"Payne A, Nahashon S, Taka E, Adinew GM, Soliman KF (2022) Epigallocatechin-3-Gallate (EGCG): New therapeutic perspectives for neuroprotection, aging, and neuroinflammation for the modern age. Biomolecules 12:371","journal-title":"Biomolecules"},{"key":"2291_CR31","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1208\/s12249-025-03145-0","volume":"26","author":"M QUTUB","year":"2025","unstructured":"Qutub M, Tatode Hussainum, Premchandani A, Umekar Tkhanr M, Taksande J, Singanwad P (2025) Nano-engineered epigallocatechin gallate (egcg) delivery systems: overcoming bioavailability barriers to unlock clinical potential in cancer therapy. AAPS PharmSciTech 26:137","journal-title":"AAPS PharmSciTech"},{"key":"2291_CR32","unstructured":"Rehak P (2021) Molecular dynamics simulations of material assembly, growth, and transport. University of Illinois Chicago"},{"key":"2291_CR33","doi-asserted-by":"publisher","first-page":"1295","DOI":"10.3390\/molecules23061295","volume":"23","author":"K SAEKI","year":"2018","unstructured":"Saeki K, Hayakawa S, Nakano S, Ito S, Oishi Y, Suzuki Y, Isemura M (2018) In vitro and in silico studies of the molecular interactions of epigallocatechin-3-O-gallate (EGCG) with proteins that explain the health benefits of green tea. Molecules 23:1295","journal-title":"Molecules"},{"key":"2291_CR34","doi-asserted-by":"publisher","first-page":"10382","DOI":"10.1080\/10408398.2022.2068500","volume":"63","author":"R SAHADEVAN","year":"2023","unstructured":"Sahadevan R, Singh S, Binoy A, Sadhukhan S (2023) Chemico-biological aspects of (\u2013)-epigallocatechin-3-gallate (EGCG) to improve its stability, bioavailability and membrane permeability: Current status and future prospects. Crit Rev Food Sci Nutr 63:10382\u201310411","journal-title":"Crit Rev Food Sci Nutr"},{"key":"2291_CR35","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1111\/febs.16122","volume":"289","author":"HM SANDERS","year":"2022","unstructured":"Sanders HM, Jovcevski B, Marty MT, Pukala TL (2022) Structural and mechanistic insights into amyloid-\u03b2 and \u03b1\u2010synuclein fibril formation and polyphenol inhibitor efficacy in phospholipid bilayers. FEBS J 289:215\u2013230","journal-title":"FEBS J"},{"key":"2291_CR36","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1016\/j.phrs.2011.02.007","volume":"64","author":"S SANG","year":"2011","unstructured":"Sang S, Ho Lambertjd C-T, Yang CS (2011) The chemistry and biotransformation of tea constituents. Pharmacol Res 64:87\u201399","journal-title":"Pharmacol Res"},{"key":"2291_CR37","doi-asserted-by":"publisher","first-page":"908","DOI":"10.1038\/s41419-022-05343-1","volume":"13","author":"J SARKAR","year":"2022","unstructured":"Sarkar J, Das M, Howlader MSI, Prateeksha P, Barthels D, Das H (2022) Epigallocatechin-3-gallate inhibits osteoclastic differentiation by modulating mitophagy and mitochondrial functions. Cell Death Dis 13:908","journal-title":"Cell Death Dis"},{"key":"2291_CR38","doi-asserted-by":"publisher","first-page":"144","DOI":"10.3390\/life10080144","volume":"10","author":"F SCOLLO","year":"2020","unstructured":"Scollo F, La Rosa C (2020) Amyloidogenic intrinsically disordered proteins: new insights into their self-assembly and their interaction with membranes. Life 10:144","journal-title":"Life"},{"key":"2291_CR39","doi-asserted-by":"publisher","first-page":"12579","DOI":"10.1038\/s41598-020-69429-6","volume":"10","author":"SK SONAWANE","year":"2020","unstructured":"Sonawane SK, Chidambaram H, Boral D, Gorantla NV, Balmik AA, Dangi A, Ramasamy S, Marelli UK, Chinnathambi S (2020) EGCG impedes human Tau aggregation and interacts with Tau. Sci Rep 10:12579","journal-title":"Sci Rep"},{"key":"2291_CR40","doi-asserted-by":"publisher","first-page":"12411","DOI":"10.3390\/ijms140612411","volume":"14","author":"M STEFANI","year":"2013","unstructured":"Stefani M, Rigacci S (2013) Protein folding and aggregation into amyloid: the interference by natural phenolic compounds. Int J Mol Sci 14:12411\u201312457","journal-title":"Int J Mol Sci"},{"key":"2291_CR41","doi-asserted-by":"publisher","first-page":"15631","DOI":"10.1038\/s41598-025-00182-4","volume":"15","author":"J SUN","year":"2025","unstructured":"Sun J, Zhuang C, Li CX, Yu L, Jin W (2025) Mechanistic insights into synergistic effects using coupled PK-PD modeling. Sci Rep 15:15631","journal-title":"Sci Rep"},{"key":"2291_CR42","doi-asserted-by":"publisher","first-page":"1161","DOI":"10.3390\/cells14151161","volume":"14","author":"M TANAKA","year":"2025","unstructured":"Tanaka M (2025) Parkinson\u2019s disease: bridging gaps, building biomarkers, and reimagining clinical translation. Cells 14:1161","journal-title":"Cells"},{"key":"2291_CR43","doi-asserted-by":"publisher","first-page":"485","DOI":"10.1007\/s11101-023-09894-9","volume":"23","author":"P UPADHYAY","year":"2024","unstructured":"Upadhyay P, Ghosh A, Sarangthem V, Singh TD (2024) Nanocarrier mediated co-delivery of phytochemicals and chemo-drugs: an emerging strategy to combat lung cancer in a systemic way. Phytochem Rev 23:485\u2013527","journal-title":"Phytochem Rev"},{"key":"2291_CR44","unstructured":"Vaidya T (2020) Multiscale and translational quantitative systems-based modeling and simulation for efficacy and safety assessment of anti-cancer agents. University of Florida"},{"key":"2291_CR45","doi-asserted-by":"crossref","unstructured":"Valdenassi L, Chirumbolo S (2025) Phytochemicals as chemical promoters of the adaptive chaos in health recovery. A modelling investigation. Chem Biodivers, e202500078","DOI":"10.1002\/cbdv.202500078"},{"key":"2291_CR46","doi-asserted-by":"publisher","first-page":"1460","DOI":"10.3390\/antiox12071460","volume":"12","author":"V VALVERDE-SALAZAR","year":"2023","unstructured":"Valverde-Salazar V, Ruiz-Gabarre D, Garc\u00eda-Escudero V (2023) Alzheimer\u2019s disease and green tea: epigallocatechin-3-gallate as a modulator of inflammation and oxidative stress. Antioxidants 12:1460","journal-title":"Antioxidants"},{"key":"2291_CR47","doi-asserted-by":"publisher","first-page":"640","DOI":"10.1016\/j.cell.2025.10.034","volume":"189","author":"J-L WANG","year":"2026","unstructured":"Wang J-L, Shao Shax-Y, Zhang Y, Huang Z-H, Lin S-M, Zhang Hgans-Y N, Xia X-Y, Sun Y-N (2026) Elucidating pathway-selective biased CCKBR agonism for Alzheimer\u2019s disease treatment. Cell 189:640\u2013658 e22","journal-title":"Cell"},{"key":"2291_CR48","doi-asserted-by":"publisher","first-page":"6516","DOI":"10.1021\/acs.chemrev.5b00562","volume":"116","author":"G WEI","year":"2016","unstructured":"Wei G, Xi W, Nussinov R, Ma B (2016) Protein ensembles: how does nature harness thermodynamic fluctuations for life? The diverse functional roles of conformational ensembles in the cell. Chem Rev 116:6516\u20136551","journal-title":"Chem Rev"},{"key":"2291_CR50","doi-asserted-by":"publisher","first-page":"8829","DOI":"10.1021\/jf401779z","volume":"61","author":"X WU","year":"2013","unstructured":"Wu X, He W, Zhang Yaol, Liu H, Wang Z, Ye WY, Cao J (2013) Characterization of binding interactions of (\u2013)-epigallocatechin-3-gallate from green tea and lipase. J Agric Food Chem 61:8829\u20138835","journal-title":"J Agric Food Chem"},{"key":"2291_CR49","doi-asserted-by":"publisher","first-page":"204","DOI":"10.1016\/j.freeradbiomed.2024.08.031","volume":"224","author":"B WU","year":"2024","unstructured":"Wu B, Zhu Xiaoq, Tang LH, Peng W (2024) Icariin targets p53 to protect against ceramide-induced neuronal senescence: implication in Alzheimer\u2019s disease. Free Radic Biol Med 224:204\u2013219","journal-title":"Free Radic Biol Med"},{"key":"2291_CR51","doi-asserted-by":"publisher","first-page":"bbab080","DOI":"10.1093\/bib\/bbab080","volume":"22","author":"J XIANG","year":"2021","unstructured":"Xiang J, Zhang J, Zheng R, Li X, Li M (2021) NIDM: network impulsive dynamics on multiplex biological network for disease-gene prediction. Brief Bioinform 22:bbab080","journal-title":"Brief Bioinform"},{"key":"2291_CR52","doi-asserted-by":"publisher","first-page":"11275","DOI":"10.3390\/ijms241411275","volume":"24","author":"L XIANG","year":"2023","unstructured":"Xiang L, Wang Y, Liu S, Liu B, Jin X, Cao X (2023) Targeting protein aggregates with natural products: an optional strategy for neurodegenerative diseases. Int J Mol Sci 24:11275","journal-title":"Int J Mol Sci"},{"key":"2291_CR53","doi-asserted-by":"publisher","first-page":"1841","DOI":"10.1021\/acschemneuro.0c00277","volume":"11","author":"C ZHAN","year":"2020","unstructured":"Zhan C, Chen Y, Tang Y, Wei G (2020) Green tea extracts EGCG and EGC display distinct mechanisms in disrupting A\u03b242 protofibril. ACS Chem Neurosci 11:1841\u20131851","journal-title":"ACS Chem Neurosci"},{"key":"2291_CR54","doi-asserted-by":"publisher","first-page":"176724","DOI":"10.1016\/j.ejphar.2024.176724","volume":"977","author":"H ZHANG","year":"2024","unstructured":"Zhang H, Wang Wangl, He Xdengl, Yi BX, Li J (2024) Mangiferin alleviated poststroke cognitive impairment by modulating lipid metabolism in cerebral ischemia\/reperfusion rats. Eur J Pharmacol 977:176724","journal-title":"Eur J Pharmacol"},{"key":"2291_CR55","doi-asserted-by":"publisher","first-page":"1581320","DOI":"10.3389\/fphar.2025.1581320","volume":"16","author":"H ZHANG","year":"2025","unstructured":"Zhang H, Zhu C, Zhou X, Wang L, Deng L, He B, Li J (2025) Edaravone dexborneol protected neurological function by targeting NRF2\/ARE and NF-\u03baB\/AIM2 pathways in cerebral ischemia\/reperfusion injury. Front Pharmacol 16:1581320","journal-title":"Front Pharmacol"},{"key":"2291_CR56","doi-asserted-by":"publisher","first-page":"e0192083","DOI":"10.1371\/journal.pone.0192083","volume":"13","author":"X ZHAO","year":"2018","unstructured":"Zhao X, Li R, Jin H, Jin H, Wang Y, Zhang W, Wang H, Chen W (2018) Epigallocatechin-3-gallate confers protection against corticosterone-induced neuron injuries via restoring extracellular signal-regulated kinase 1\/2 and phosphatidylinositol-3 kinase\/protein kinase B signaling pathways. PLoS ONE 13:e0192083","journal-title":"PLoS ONE"},{"key":"2291_CR58","unstructured":"Zhou L (2013) Elucidation of pro-oxidant mechanisms of the bioactive polyphenol,(-)-epigallocatechin gallate, in food emulsions"},{"key":"2291_CR59","doi-asserted-by":"publisher","first-page":"387","DOI":"10.1186\/s12859-020-03682-4","volume":"21","author":"R ZHOU","year":"2020","unstructured":"Zhou R, Lu Z, Luo H, Zeng Xiangj M, li M (2020) NEDD: a network embedding based method for predicting drug-disease associations. BMC Bioinformatics 21:387","journal-title":"BMC Bioinformatics"},{"key":"2291_CR57","doi-asserted-by":"crossref","unstructured":"Zhou C, Chen Yuz, Zhang Tchenq, Xu Ycaij C, Yu L (2025) Tanshinone IIA attenuates cerebral-ischemia-reperfusion-induced neuroinflammation by inhibiting the TLR4\/NF-\u03baB signaling cascade: a study integrating network pharmacology, bioinformatics, and experimental validation. Phytomedicine, 157548","DOI":"10.1016\/j.phymed.2025.157548"},{"key":"2291_CR60","doi-asserted-by":"publisher","first-page":"1232","DOI":"10.3390\/foods13081232","volume":"13","author":"Y ZHUANG","year":"2024","unstructured":"Zhuang Y, Quan W, Wang X, Cheng Y, Jiao Y (2024) Comprehensive review of EGCG modification: esterification methods and their impacts on biological activities. Foods 13:1232","journal-title":"Foods"},{"key":"2291_CR61","doi-asserted-by":"publisher","first-page":"4027","DOI":"10.3390\/ijms22084027","volume":"22","author":"I ZWOLAK","year":"2021","unstructured":"Zwolak I (2021) Epigallocatechin gallate for management of heavy metal-induced oxidative stress: mechanisms of action, efficacy, and concerns. Int J Mol Sci 22:4027","journal-title":"Int J Mol Sci"}],"container-title":["Inflammopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10787-026-02291-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10787-026-02291-6","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10787-026-02291-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T08:02:20Z","timestamp":1784707340000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10787-026-02291-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,15]]},"references-count":61,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2026,7]]}},"alternative-id":["2291"],"URL":"https:\/\/doi.org\/10.1007\/s10787-026-02291-6","relation":{},"ISSN":["0925-4692","1568-5608"],"issn-type":[{"value":"0925-4692","type":"print"},{"value":"1568-5608","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,15]]},"assertion":[{"value":"1 January 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 April 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 June 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. The authors declare the following financial interests\/personal relationships which may be considered as potential competing interests.","order":1,"name":"Ethics","label":"Conflict of interest","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":2,"name":"Ethics","label":"Ethical approval","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":3,"name":"Ethics","label":"Consent for publication","group":{"name":"EthicsHeading","label":"Declarations"}}]}}