{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T08:01:41Z","timestamp":1784707301495,"version":"3.55.0"},"reference-count":64,"publisher":"Springer Science and Business Media LLC","issue":"7","license":[{"start":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T00:00:00Z","timestamp":1781222400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T00:00:00Z","timestamp":1781222400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100008132","name":"Universidade Federal De Pernambuco","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100008132","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Inflammopharmacol"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Natural products derived from medicinal plants represent an important source of bioactive compounds with potential therapeutic applications in the management of pain and inflammatory disorders. In this study, the chemical profile and pharmacological activities of the aqueous extract obtained from the fruit peel of\n                    <jats:italic>Myrciaria floribunda<\/jats:italic>\n                    (AeMf) were investigated. Chemical characterization was performed using high-performance liquid chromatography coupled with electrospray ionization mass spectrometry (HPLC\u2013ESI\u2013MS\u207f). The antinociceptive activity of AeMf was evaluated in mice using acetic acid\u2013induced abdominal writhing, formalin, and tail immersion tests, while the anti-inflammatory potential was assessed through carrageenan-induced paw edema and peritonitis models. Chromatographic analysis revealed a chemical profile predominantly composed of organic acids and related metabolites, including quinic acid, citrate, maleate, and a fatty acid hexoside. In nociceptive models, AeMf produced a significant and dose-dependent reduction in acetic acid\u2013induced writhing and markedly decreased paw-licking behavior in both phases of the formalin test. In addition, the extract increased tail withdrawal latency in the thermal nociception assay, indicating the involvement of both peripheral and central analgesic mechanisms. In inflammatory models, AeMf significantly inhibited carrageenan-induced paw edema, reduced leukocyte and neutrophil migration to the peritoneal cavity, and markedly suppressed the production of pro-inflammatory cytokines, including TNF-\u03b1 and IL-1\u03b2. Collectively, these findings demonstrate that AeMf exerts potent antinociceptive and anti-inflammatory effects, likely mediated through the modulation of inflammatory mediators and cellular recruitment. The results highlight the therapeutic potential of\n                    <jats:italic>Myrciaria floribunda<\/jats:italic>\n                    as a promising natural source of bioactive compounds for the development of novel strategies for pain and inflammation management.\n                  <\/jats:p>","DOI":"10.1007\/s10787-026-02294-3","type":"journal-article","created":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T06:36:52Z","timestamp":1781246212000},"page":"4643-4655","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Chemical characterization and antinociceptive and anti-inflammatory activities of the aqueous extract of Myrciaria floribunda (H. West ex Willd.) O. Berg fruit peel"],"prefix":"10.1007","volume":"34","author":[{"given":"Simone Patricia","family":"De Freitas Rosa","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Izabelly Bianca","family":"da Silva Santos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wendel C\u00e9sar eSilva","family":"Pereira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tha\u00eds Vit\u00f3ria Freitas","family":"de Souza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paulo Henrique Eloi","family":"Fernandes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriela Ribeiro","family":"de Sousa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 Fernandes","family":"da Silva Cardoso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alisson Mac\u00e1rio","family":"de Oliveira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M\u00e1rcia Vanusa","family":"da Silva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W\u00eandeo Kennedy","family":"Costa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Tereza","family":"dos Santos Correia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,6,12]]},"reference":[{"key":"2294_CR1","doi-asserted-by":"publisher","unstructured":"Abdellatif KRA, Abdelall EKA, Elshemy HAH, El-Nahass ES, Abdel-Fattah MM, Abdelgawad YYM (2021) New indomethacin analogs as selective COX-2 inhibitors: Synthesis, COX-1\/2 inhibitory activity, anti-inflammatory, ulcerogenicity, histopathological, and docking studies. Arch Pharm (Weinheim). 354(4):e2000328. https:\/\/doi.org\/10.1002\/ardp.202000328","DOI":"10.1002\/ardp.202000328"},{"issue":"2","key":"2294_CR2","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1080\/07388551.2019.1709799","volume":"40","author":"A Amato","year":"2020","unstructured":"Amato A, Becci A, Beolchini F (2020) Citric acid bioproduction: the technological innovation change. Crit Rev Biotechnol 40(2):199\u2013212. https:\/\/doi.org\/10.1080\/07388551.2019.1709799","journal-title":"Crit Rev Biotechnol"},{"issue":"2","key":"2294_CR3","doi-asserted-by":"publisher","first-page":"105","DOI":"10.51507\/j.jams.2022.15.2.105","volume":"15","author":"IPR Arg\u00f4lo","year":"2022","unstructured":"Arg\u00f4lo IPR, Parisi JR, Silva JRTD, Silva MLD (2022) Participation of Potential Transient Receptors in the Antinociceptive Effect of Pharmacopuncture. J Acupunct Meridian Stud 15(2):105\u2013113. https:\/\/doi.org\/10.51507\/j.jams.2022.15.2.105","journal-title":"J Acupunct Meridian Stud"},{"key":"2294_CR4","doi-asserted-by":"publisher","unstructured":"Bannon AW, Malmberg AB (2007) Models of nociception: hot-plate, tail-flick, and formalin tests in rodents. Curr Protoc Neurosci. 2007 Oct;Chapter 8:Unit 8.9. https:\/\/doi.org\/10.1002\/0471142301.ns0809s41","DOI":"10.1002\/0471142301.ns0809s41"},{"key":"2294_CR5","doi-asserted-by":"publisher","unstructured":"Barbosa DCDS, Holanda VN, Ghosh A, Maia RT, da Silva WV, Lima VLM, da Silva MV, Dos Santos Correia MT, de Figueiredo RCBQ (2022) Leishmanicidal and cytotoxic activity of essential oil from the fruit peel of Myrciaria floribunda (H. West ex Willd.) O. Berg: Molecular docking and molecular dynamics simulations of its major constituent onto Leishmania enzyme targets. J Biomol Struct Dyn. 40(23):13001\u201313016. https:\/\/doi.org\/10.1080\/07391102.2021.1978320","DOI":"10.1080\/07391102.2021.1978320"},{"issue":"4","key":"2294_CR6","doi-asserted-by":"publisher","first-page":"3408","DOI":"10.1080\/02648725.2022.2122303","volume":"40","author":"T Benali","year":"2024","unstructured":"Benali T, Bakrim S, Ghchime R, Benkhaira N, El Omari N, Balahbib A, Taha D, Zengin G, Hasan MM, Bibi S, Bouyahya A (2024) Pharmacological insights into the multifaceted biological properties of quinic acid. Biotechnol Genet Eng Rev 40(4):3408\u20133437. https:\/\/doi.org\/10.1080\/02648725.2022.2122303","journal-title":"Biotechnol Genet Eng Rev"},{"issue":"5","key":"2294_CR7","doi-asserted-by":"publisher","first-page":"480","DOI":"10.1016\/j.ejpain.2009.08.005","volume":"14","author":"K B\u00f6lcskei","year":"2010","unstructured":"B\u00f6lcskei K, T\u00e9kus V, D\u00e9zsi L, Szolcs\u00e1nyi J, Petho G (2010) Antinociceptive desensitizing actions of TRPV1 receptor agonists capsaicin, resiniferatoxin and N- oleoyldopamine as measured by determination of the noxious heat and cold thresholds in the rat. Eur J Pain 14(5):480\u2013486. https:\/\/doi.org\/10.1016\/j.ejpain.2009.08.005","journal-title":"Eur J Pain"},{"issue":"7986","key":"2294_CR8","doi-asserted-by":"publisher","first-page":"415","DOI":"10.1038\/s41586-023-06685-2","volume":"623","author":"N Caronni","year":"2023","unstructured":"Caronni N, La Terza F, Vittoria FM, Barbiera G, Mezzanzanica L, Cuzzola V, Ostuni R (2023) IL-1\u03b2+ macrophages fuel pathogenic inflammation in pancreatic cancer. Nature 623(7986):415\u2013422","journal-title":"Nature"},{"key":"2294_CR9","doi-asserted-by":"publisher","unstructured":"Choi JY, Lee JW, Jang H, Kim JG, Lee MK, Hong JT, Lee MS, Hwang BY (2021) Quinic acid esters from Erycibe obtusifolia with antioxidant and tyrosinase inhibitory activities. Nat Prod Res. 35(18):3026\u20133032. https:\/\/doi.org\/10.1080\/14786419.2019.1684285","DOI":"10.1080\/14786419.2019.1684285"},{"issue":"7","key":"2294_CR10","doi-asserted-by":"publisher","first-page":"2234","DOI":"10.3390\/molecules27072234","volume":"27","author":"JS Costa","year":"2022","unstructured":"Costa JS, Andrade WMS, de Figueiredo RO, Santos PVL, Freitas JJDS, Setzer WN, da Silva JKR, Maia JGS, Figueiredo PLB (2022) Chemical Composition and Variability of the Volatile Components of Myrciaria Species Growing in the Amazon Region. Molecules 27(7):2234. https:\/\/doi.org\/10.3390\/molecules27072234","journal-title":"Molecules"},{"issue":"1","key":"2294_CR11","doi-asserted-by":"publisher","first-page":"595","DOI":"10.1007\/s10787-023-01351-5","volume":"32","author":"WK Costa","year":"2024","unstructured":"Costa WK, Guimar\u00e3es VB, da Fons\u00eaca BMB, Ferreira MRA, Soares LAL, Napole\u00e3o TH, Paiva PMG, Dos Santos Correia MT, Dos Santos FAB, de Oliveira AM, da Silva MV (2024) Development of gel containing Psidium glaziovianum essential oil has in vitro antimicrobial activity and improves healing of excisional wounds in mice. Inflammopharmacology 32(1):595\u2013602. https:\/\/doi.org\/10.1007\/s10787-023-01351-5","journal-title":"Inflammopharmacology"},{"key":"2294_CR12","doi-asserted-by":"publisher","unstructured":"Costa WK, do Nascimento MF, Dos Santos CRB, Dede Oliveira FariasAguiar JCR, do Amaral Ferraz Navarro DM, Napole\u00e3o TH, Dos Santos Correia MT, Brayner FA, de Oliveira AM, da Silva MV (2022) Oral administration of essential oil from Psidium glaziovianum Kiaersk leaves alleviates pain and inflammation in mice. Inflammopharmacology. 30(2):599\u2013607. https:\/\/doi.org\/10.1007\/s10787-022- 00940\u20130","DOI":"10.1007\/s10787-022"},{"key":"2294_CR13","doi-asserted-by":"publisher","first-page":"102905","DOI":"10.1016\/j.tice.2025.102905","volume":"95","author":"FM El-Demerdash","year":"2025","unstructured":"El-Demerdash FM, Mohammed LT, Mohamed TM (2025) Modulatory effect of Eruca vesicaria seeds essential oil on acetamiprid nephrotoxicity via oxidative stress inhibition and regulation of Cox-2, TNF-\u03b1, and PPAR-\u03b1 pathways. Tissue Cell 95:102905. https:\/\/doi.org\/10.1016\/j.tice.2025.102905","journal-title":"Tissue Cell"},{"issue":"1","key":"2294_CR14","doi-asserted-by":"publisher","first-page":"139","DOI":"10.22092\/ari.2019.127569.1387","volume":"76","author":"A Esmaili","year":"2021","unstructured":"Esmaili A, Kamyab M, Fatemikia H, Ahmadzadeh H, Movahed A, Kim E, Mohamadpour Dounighi N, Salemi A, Seyedian R (2021) Experimental Evaluation of Mouse Hind Paw Edema Induced by Iranian Naja oxiana Venom. Arch Razi Inst 76(1):139\u2013147. https:\/\/doi.org\/10.22092\/ari.2019.127569.1387","journal-title":"Arch Razi Inst"},{"issue":"13","key":"2294_CR15","doi-asserted-by":"publisher","first-page":"866747","DOI":"10.3389\/fimmu.2022.866747","volume":"16","author":"JG Filep","year":"2022","unstructured":"Filep JG (2022) Targeting Neutrophils for Promoting the Resolution of Inflammation. Front Immunol 16(13):866747. https:\/\/doi.org\/10.3389\/fimmu.2022.866747","journal-title":"Front Immunol"},{"issue":"3","key":"2294_CR16","doi-asserted-by":"publisher","first-page":"511","DOI":"10.1016\/j.pain.2013.11.015","volume":"155","author":"M Fischer","year":"2014","unstructured":"Fischer M, Carli G, Raboisson P, Reeh P (2014) The interphase of the formalin test. Pain 155(3):511\u2013521. https:\/\/doi.org\/10.1016\/j.pain.2013.11.015","journal-title":"Pain"},{"key":"2294_CR17","doi-asserted-by":"publisher","unstructured":"Fok ET, Moorlag SJCFM, Negishi Y, Groh LA, Dos Santos JC, Gr\u00e4we C, Monge VV, Craenmehr DDD, van Roosmalen M, da Cunha Jolvino DP, Migliorini LB, Neto AS, Severino P, Vermeulen M, Joosten LAB, Netea MG, Fanucchi S, Mhlanga MM (2024) A chromatin-regulated biphasic circuit coordinates IL-1\u03b2-mediated inflammation. Nat Genet. 56(1):85\u201399. https:\/\/doi.org\/10.1038\/s41588-023- 01598\u20132.","DOI":"10.1038\/s41588-023"},{"key":"2294_CR18","doi-asserted-by":"publisher","unstructured":"Haro-Gonz\u00e1lez JN, Castillo-Herrera GA, Mart\u00ednez-Vel\u00e1zquez M, Espinosa-Andrews H (2021) Clove Essential Oil (Syzygium aromaticum L. Myrtaceae): Extraction, Chemical Composition, Food Applications, and Essential Bioactivity for Human Health. Molecules. 26(21):6387. https:\/\/doi.org\/10.3390\/molecules26216387","DOI":"10.3390\/molecules26216387"},{"issue":"2","key":"2294_CR19","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1038\/s41423-021-00832-3","volume":"19","author":"A Herrero-Cervera","year":"2022","unstructured":"Herrero-Cervera A, Soehnlein O, Kenne E (2022) Neutrophils in chronic inflammatory diseases. Cell Mol Immunol 19(2):177\u2013191","journal-title":"Cell Mol Immunol"},{"issue":"6","key":"2294_CR20","doi-asserted-by":"publisher","first-page":"16597","DOI":"10.1007\/s11356-022-23343-8","volume":"30","author":"HHA Hijazy","year":"2023","unstructured":"Hijazy HHA, Dahran N, Althagafi HA, Alharthi F, Habotta OA, Oyouni AAA, Algahtani M, Theyab A, Al-Amer O, Lokman MS, Alsharif KF, Albrakati A, Amin HK, Dawood SM, Kassab RB, Ellethy RA (2023) Thymoquinone counteracts oxidative and inflammatory machinery in carrageenan-induced murine paw edema model. Environ Sci Pollut Res Int 30(6):16597\u201316611","journal-title":"Environ Sci Pollut Res Int"},{"issue":"2","key":"2294_CR21","doi-asserted-by":"publisher","first-page":"1239","DOI":"10.3390\/ijms25021239","volume":"25","author":"P Hu","year":"2024","unstructured":"Hu P, Yuan M, Guo B, Lin J, Yan S, Huang H, Chen JL, Wang S, Ma Y (2024) Citric Acid Promotes Immune Function by Modulating the Intestinal Barrier. Int J Mol Sci 25(2):1239. https:\/\/doi.org\/10.3390\/ijms25021239","journal-title":"Int J Mol Sci"},{"issue":"1","key":"2294_CR22","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1016\/0304-3959(87)90088-1","volume":"30","author":"S Hunskaar","year":"1987","unstructured":"Hunskaar S, Hole K (1987) The formalin test in mice: dissociation between inflammatory and non-inflammatory pain. Pain 30(1):103\u2013114","journal-title":"Pain"},{"issue":"2","key":"2294_CR23","doi-asserted-by":"publisher","first-page":"231","DOI":"10.1007\/s10517-024-06162-4","volume":"177","author":"EA Ivanova","year":"2024","unstructured":"Ivanova EA, Vasilchuk AG, Voronina TA (2024) Protein Kinase A Inhibitor Attenuates the Antinociceptive Effect of NMDA-Receptor Channel Antagonists in the Capsaicin Test in Mice. Bull Exp Biol Med 177(2):231\u2013234","journal-title":"Bull Exp Biol Med"},{"key":"2294_CR24","doi-asserted-by":"publisher","unstructured":"Jaffal S, Thipayarat A, Alqaraleh S, Wongwiwat J, Supanivatin P (2025) Jasmine sambac L. essential oil attenuates inflammation and pain via TRPV1. Inflammopharmacology. 33(10):6099\u20136110. https:\/\/doi.org\/10.1007\/s10787-025- 01929\u20131","DOI":"10.1007\/s10787-025"},{"key":"2294_CR25","doi-asserted-by":"publisher","unstructured":"Jena S, Ray A, Mohanta O, Das PK, Sahoo A, Nayak S, Panda PC (2022) Neocinnamomum caudatum Essential Oil Ameliorates Lipopolysaccharide-Induced Inflammation and Oxidative Stress in RAW 264.7 Cells by Inhibiting NF-\u03baB Activation and ROS Production. Molecules. 27(23):8193. https:\/\/doi.org\/10.3390\/molecules27238193","DOI":"10.3390\/molecules27238193"},{"issue":"5","key":"2294_CR26","doi-asserted-by":"publisher","first-page":"1034","DOI":"10.1021\/acs.jpcb.1c05050","volume":"126","author":"C Jeong","year":"2022","unstructured":"Jeong C, Franklin R, Edler KJ, Vanommeslaeghe K, Krueger S, Curtis JE (2022) Styrene- Maleic Acid Copolymer Nanodiscs to Determine the Shape of Membrane Proteins. J Phys Chem B 126(5):1034\u20131044. https:\/\/doi.org\/10.1021\/acs.jpcb.1c05050","journal-title":"J Phys Chem B"},{"issue":"1","key":"2294_CR27","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1186\/s12906-015-0558-y","volume":"15","author":"A Khatun","year":"2015","unstructured":"Khatun A, Imam MZ, Rana MS (2015) Antinociceptive effect of methanol extract of leaves of Persicaria hydropiper in mice. BMC Complement Altern Med 15(1):63","journal-title":"BMC Complement Altern Med"},{"issue":"1","key":"2294_CR28","doi-asserted-by":"publisher","first-page":"22","DOI":"10.3390\/molecules29010022","volume":"29","author":"E Ksi\u0105\u017cek","year":"2023","unstructured":"Ksi\u0105\u017cek E (2023) Citric Acid: Properties, Microbial Production, and Applications in Industries. Molecules 29(1):22. https:\/\/doi.org\/10.3390\/molecules29010022","journal-title":"Molecules"},{"issue":"12","key":"2294_CR29","doi-asserted-by":"publisher","first-page":"1619","DOI":"10.3390\/biom14121619","volume":"14","author":"E Kumamoto","year":"2024","unstructured":"Kumamoto E (2024) Anesthetic- and Analgesic-Related Drugs Modulating Both Voltage- Gated Na+ and TRP Channels. Biomolecules 14(12):1619. https:\/\/doi.org\/10.3390\/biom14121619","journal-title":"Biomolecules"},{"issue":"6","key":"2294_CR30","doi-asserted-by":"publisher","first-page":"425","DOI":"10.4196\/kjpp.2009.13.6.425","volume":"13","author":"YB Kwon","year":"2009","unstructured":"Kwon YB, Jeong YC, Kwon JK, Son JS, Kim KW (2009) The antinociceptive effect of sigma-1 receptor antagonist, BD1047, in a capsaicin induced headache model in rats. Korean J Physiol Pharmacol 13(6):425\u2013429. https:\/\/doi.org\/10.4196\/kjpp.2009.13.6.425","journal-title":"Korean J Physiol Pharmacol"},{"key":"2294_CR31","unstructured":"Lapa AJ, Souccar C, Lima-Landman TR, Castro MAS, Lima TCM (2008) Plantas medicinais: m\u00e9todos de avalia\u00e7\u00e3o da atividade farmacol\u00f3gica. Sociedade Brasileira de Plantas Medicinais, 144"},{"issue":"1","key":"2294_CR32","doi-asserted-by":"publisher","first-page":"2374608","DOI":"10.1080\/19490976.2024.2374608","volume":"16","author":"S Li","year":"2024","unstructured":"Li S, Cai Y, Guan T, Zhang Y, Huang K, Zhang Z, Cao W, Guan X (2024) Quinic acid alleviates high-fat diet-induced neuroinflammation by inhibiting DR3\/IKK\/NF-\u03baB signaling via gut microbial tryptophan metabolites. Gut Microbes 16(1):2374608. https:\/\/doi.org\/10.1080\/19490976.2024.2374608","journal-title":"Gut Microbes"},{"key":"2294_CR33","doi-asserted-by":"publisher","first-page":"272","DOI":"10.1016\/j.jconrel.2023.10.030","volume":"364","author":"D Lin","year":"2023","unstructured":"Lin D, Xu X, Chen L, Chen L, Deng M, Chen J, Ren Z, Lei L, Wang J, Deng J, Li X (2023) Supramolecular nanofiber of indomethacin derivative confers highly cyclooxygenase-2 (COX-2) selectivity and boosts anti-inflammatory efficacy. J Control Release 364:272\u2013282. https:\/\/doi.org\/10.1016\/j.jconrel.2023.10.030","journal-title":"J Control Release"},{"key":"2294_CR34","doi-asserted-by":"publisher","first-page":"627725","DOI":"10.3389\/fmed.2021.627725","volume":"8","author":"X Liu","year":"2021","unstructured":"Liu X, Zhang JT, Hu Y, Shan WQ, Wang ZH, Fu QY, Fu DN, Ji J, Liu T (2021) Formalin itch test: low-dose formalin induces histamine-independent, TRPA1-mediated itch in mice. Front Med 8:627725. https:\/\/doi.org\/10.3389\/fmed.2021.627725","journal-title":"Front Med"},{"issue":"17","key":"2294_CR35","doi-asserted-by":"publisher","first-page":"10016","DOI":"10.3390\/ijms231710016","volume":"23","author":"K Louis-Gray","year":"2022","unstructured":"Louis-Gray K, Tupal S, Premkumar LS (2022) TRPV1: a common denominator mediating antinociceptive and antiemetic effects of cannabinoids. Int J Mol Sci 23(17):10016. https:\/\/doi.org\/10.3390\/ijms231710016","journal-title":"Int J Mol Sci"},{"key":"2294_CR36","doi-asserted-by":"publisher","unstructured":"Moraes \u00c2AB, Ferreira OO, da Costa LS, Almeida LQ, Varela ELP, Cascaes MM, de Jesus Pereira Franco C, Perc\u00e1rio S, Nascimento LDD, de Oliveira MS, Andrade EHA (2022) Phytochemical Profile, Preliminary Toxicity, and Antioxidant Capacity of the Essential Oils of Myrciaria floribunda (H. West ex Willd.) O. Berg. and Myrcia sylvatica (G. Mey) DC. (Myrtaceae). Antioxidants (Basel). 11(10):2076. https:\/\/doi.org\/10.3390\/antiox11102076.","DOI":"10.3390\/antiox11102076"},{"issue":"5","key":"2294_CR37","doi-asserted-by":"publisher","first-page":"603","DOI":"10.4196\/kjpp.25.039","volume":"29","author":"TQ Nguyen","year":"2025","unstructured":"Nguyen TQ, Tran TQN, Jang SH, Park SA, Han SK (2025) Inhibitory action of citronellol on the substantia gelatinosa neurons of the trigeminal subnucleus caudalis in juvenile mice. Korean J Physiol Pharmacol 29(5):603\u2013611. https:\/\/doi.org\/10.4196\/kjpp.25.039","journal-title":"Korean J Physiol Pharmacol"},{"key":"2294_CR38","doi-asserted-by":"publisher","first-page":"394632022111113","DOI":"10.1177\/03946320221111135","volume":"36","author":"JH Oh","year":"2022","unstructured":"Oh JH, Kim SH, Kwon OK, Kim JH, Oh SR, Han SB, Park JW, Ahn KS (2022) Purpurin suppresses atopic dermatitis via TNF-\u03b1\/IFN-\u03b3-induced inflammation in HaCaT cells. Int J Immunopathol Pharmacol 36:3946320221111135. https:\/\/doi.org\/10.1177\/03946320221111135","journal-title":"Int J Immunopathol Pharmacol"},{"key":"2294_CR39","doi-asserted-by":"publisher","first-page":"289","DOI":"10.1016\/j.yrtph.2018.04.004","volume":"95","author":"AM Oliveira","year":"2018","unstructured":"Oliveira AM, de Luna Freire MO, da Silva WAV, Ferreira MRA, Paiva PMG, Soares LAL, Napole\u00e3o TH (2018a) Saline extract of Pilosocereus gounellei stem has antinociceptive effect in mice without showing acute toxicity and altering motor coordination. Regul Toxicol Pharmacol 95:289\u2013297","journal-title":"Regul Toxicol Pharmacol"},{"key":"2294_CR40","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1016\/j.foodchem.2017.12.053","volume":"248","author":"LM Oliveira","year":"2018","unstructured":"Oliveira LM, Porte A, de Oliveira Godoy RL, da Costa Souza M, Pacheco S, de Araujo Santiago MCP, Gouv\u00eaa ACMS, da Silva de Mattos do Nascimento L, Borguini RG (2018b) Chemical characterization of Myrciaria floribunda (H. West ex Willd) fruit. Food Chem 248:247\u2013252. https:\/\/doi.org\/10.1016\/j.foodchem.2017.12.053","journal-title":"Food Chem"},{"key":"2294_CR41","doi-asserted-by":"publisher","first-page":"125630","DOI":"10.1016\/j.foodchem.2019.125630","volume":"306","author":"D Paulo Farias","year":"2020","unstructured":"Paulo Farias D, Neri-Numa IA, de Ara\u00fajo FF, Pastore GM (2020) A critical review of some fruit trees from the Myrtaceae family as promising sources for food applications with functional claims. Food Chem 306:125630. https:\/\/doi.org\/10.1016\/j.foodchem.2019.125630","journal-title":"Food Chem"},{"key":"2294_CR42","doi-asserted-by":"publisher","first-page":"110774","DOI":"10.1016\/j.brainresbull.2023.110774","volume":"203","author":"K Rahimi","year":"2023","unstructured":"Rahimi K, Zalaghi M, Shehnizad EG, Salari G, Baghdezfoli F, Ebrahimifar A (2023) The effects of alpha-pinene on inflammatory responses and oxidative stress in the formalin test. Brain Res Bull 203:110774. https:\/\/doi.org\/10.1016\/j.brainresbull.2023.110774","journal-title":"Brain Res Bull"},{"issue":"1","key":"2294_CR43","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1016\/0160-5402(89)90019-3","volume":"21","author":"K Ramabadran","year":"1989","unstructured":"Ramabadran K, Bansinath M, Turndorf H, Puig MM (1989) Tail immersion test for the evaluation of a nociceptive reaction in mice. Methodol Consider J Pharmacol Methods 21(1):21\u201331","journal-title":"Methodol Consider J Pharmacol Methods"},{"issue":"20","key":"2294_CR44","doi-asserted-by":"publisher","first-page":"4800","DOI":"10.3390\/molecules29204800","volume":"29","author":"A Renny","year":"2024","unstructured":"Renny A, Sidhic J, Tom A, Kuttithodi AM, Job JT, Rajagopal R, Alfarhan A, Narayanankutty A (2024) Methanol Extract of Thottea siliquosa (Lam.) Ding Hou Leaves Inhibits Carrageenan- and Formalin-Induced Paw Edema in Mice. Molecules 29(20):4800. https:\/\/doi.org\/10.3390\/molecules29204800","journal-title":"Molecules"},{"issue":"3","key":"2294_CR45","doi-asserted-by":"publisher","first-page":"573","DOI":"10.1016\/j.cbi.2013.03.014","volume":"203","author":"ER Rios","year":"2013","unstructured":"Rios ER, Rocha NF, Carvalho AM, Vasconcelos LF, Dias ML, de Sousa DP, de Sousa FC, Fonteles MM (2013) TRP and ASIC channels mediate the antinociceptive effect of citronellyl acetate. Chem Biol Interact 203(3):573\u2013579. https:\/\/doi.org\/10.1016\/j.cbi.2013.03.014","journal-title":"Chem Biol Interact"},{"key":"2294_CR46","doi-asserted-by":"publisher","first-page":"128382","DOI":"10.1016\/j.biortech.2022.128382","volume":"369","author":"L Risanto","year":"2023","unstructured":"Risanto L, Adi DTN, Fajriutami T, Teramura H, Fatriasari W, Hermiati E, Kahar P, Kondo A, Ogino C (2023) Pretreatment with dilute maleic acid enhances the enzymatic digestibility of sugarcane bagasse and oil palm empty fruit bunch fiber. Bioresour Technol 369:128382. https:\/\/doi.org\/10.1016\/j.biortech.2022.128382","journal-title":"Bioresour Technol"},{"issue":"5","key":"2294_CR47","doi-asserted-by":"publisher","first-page":"613","DOI":"10.1161\/ATVBAHA.121.317168","volume":"42","author":"W Rong","year":"2022","unstructured":"Rong W, Liu C, Li X, Wan N, Wei L, Zhu W, Bai P, Li M, Ou Y, Li F, Wang L, Wu X, Liu J, Xing M, Zhao X, Liu H, Zhang H, Lyu A (2022) Caspase-8 Promotes Pulmonary Hypertension by Activating Macrophage-Associated Inflammation and IL-1\u03b2 (Interleukin 1\u03b2) Production. Arterioscler Thromb Vasc Biol 42(5):613\u2013631. https:\/\/doi.org\/10.1161\/ATVBAHA.121.317168","journal-title":"Arterioscler Thromb Vasc Biol"},{"issue":"3","key":"2294_CR48","doi-asserted-by":"publisher","first-page":"1069","DOI":"10.1007\/s10787-023-01136-w","volume":"31","author":"M Sadeghi","year":"2023","unstructured":"Sadeghi M, Dehnavi S, Asadirad A, Xu S, Majeed M, Jamialahmadi T, Johnston TP, Sahebkar A (2023) Curcumin and chemokines: mechanism of action and therapeutic potential in inflammatory diseases. Inflammopharmacology 31(3):1069\u20131093. https:\/\/doi.org\/10.1007\/s10787-023-01136-w","journal-title":"Inflammopharmacology"},{"issue":"1\u20132","key":"2294_CR49","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1024\/0300-9831\/a000620","volume":"91","author":"S Salem","year":"2021","unstructured":"Salem S, Leghouchi E, Soulimani R, Bouayed J (2021) Reduction of paw edema and liver oxidative stress in carrageenan-induced acute inflammation by Lobaria pulmonaria and Parmelia caperata, lichen species, in mice. Int J Vitam Nutr Res 91(1\u20132):143\u2013151. https:\/\/doi.org\/10.1024\/0300-9831\/a000620","journal-title":"Int J Vitam Nutr Res"},{"key":"2294_CR50","doi-asserted-by":"publisher","unstructured":"Santos de Moraes PG, da Silva Santos IB, Silva VBG, Dede Oliveira FariasAguiar JCR, do Amaral Ferraz Navarro DM, de Oliveira AM, Dos Santos Correia MT, Costa WK, da Silva MV (2023) Essential oil from leaves of Myrciaria floribunda (H. West ex Willd.) O. Berg has antinociceptive and anti-inflammatory potential. Inflammopharmacology. 31(6):3143\u20133151. https:\/\/doi.org\/10.1007\/s10787-023- 01300\u20132.","DOI":"10.1007\/s10787-023"},{"key":"2294_CR51","doi-asserted-by":"publisher","unstructured":"Santos IBDS, Santos Dos Santos B, de Oliveira JRS, Costa WK, Zagmignan A, da Silva LCN, Ferreira MRA, Lermen VL, Lermen MSBS, da Silva AG, Ximenes RM, Soares LAL, Paiva PMG, Lima VLM, Correia MTDS, da Silva MV (2020) Antioxidant Action and In Vivo Anti-Inflammatory and Antinociceptive Activities of Myrciaria floribunda Fruit Peels: Possible Involvement of Opioidergic System. Adv Pharmacol Pharm Sci. 2020:1258707. https:\/\/doi.org\/10.1155\/2020\/1258707","DOI":"10.1155\/2020\/1258707"},{"key":"2294_CR52","doi-asserted-by":"publisher","unstructured":"Santos-Neves PS, Bezerra-Silva A, Gomes MTD, ACAF, MIUO, Voeks RA, EMCN, Funch LS (2024) Biocultural heritage of the Caatinga: a systematic review of Myrtaceae and its multiple uses. Biol Rev Camb Philos Soc. 99(5):1791\u20131805. https:\/\/doi.org\/10.1111\/brv.13092","DOI":"10.1111\/brv.13092"},{"key":"2294_CR53","doi-asserted-by":"publisher","first-page":"116443","DOI":"10.1016\/j.jep.2023.116443","volume":"312","author":"VBG Silva","year":"2023","unstructured":"Silva VBG, Barros da Fons\u00eaca BM, de Oliveira R, Farias de Aguiar JC et al (2023) Chemical composition, antinociceptive and anti-inflammatory effects in mice of the essential oil of Psidium cattleyanum Sabine leaves. J Ethnopharmacol 312:116443. https:\/\/doi.org\/10.1016\/j.jep.2023.116443","journal-title":"J Ethnopharmacol"},{"key":"2294_CR54","doi-asserted-by":"publisher","unstructured":"Silva Santos IB, de Freitas Rosa SP, Pereira WCE, Dos Santos BS, de Lima NTR, Filho JMB, de Oliveira AM, Napole\u00e3o TH, Dos Santos Correia MT, Costa WK, da Silva MV (2025) In vitro antioxidant activity and in vivo antinociceptive and anti- inflammatory effects of the hydroethanolic extract from leaves of Myrciaria floribunda (H. West ex Willd.) O. Berg in Swiss mice. Inflammopharmacology. 33(10):6273\u20136285. https:\/\/doi.org\/10.1007\/s10787-025-01972-y","DOI":"10.1007\/s10787-025-01972-y"},{"issue":"5","key":"2294_CR55","doi-asserted-by":"publisher","first-page":"893","DOI":"10.3390\/plants10050893","volume":"10","author":"KS Silva-Alves","year":"2021","unstructured":"Silva-Alves KS, Ferreira-da-Silva FW, Coelho-de-Souza AN, Leal-Cardoso JH (2021) Essential Oil of Croton zehntneri Prevents Conduction Alterations Produced by Diabetes Mellitus on Vagus Nerve. Plants (Basel) 10(5):893. https:\/\/doi.org\/10.3390\/plants10050893","journal-title":"Plants (Basel)"},{"key":"2294_CR56","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1016\/j.jep.2017.02.025","volume":"200","author":"RR Sim\u00f5es","year":"2017","unstructured":"Sim\u00f5es RR, Coelho ID, Junqueira SC, Pigatto GR, Salvador MJ, Santos AR, Faria FM (2017) Oral treatment with essential oil of Hyptis spicigera Lam. (Lamiaceae) reduces acute pain and inflammation in mice: Potential interactions with transient receptor potential (TRP) ion channels. J Ethnopharmacol 200:8\u201315. https:\/\/doi.org\/10.1016\/j.jep.2017.02.025","journal-title":"J Ethnopharmacol"},{"key":"2294_CR57","doi-asserted-by":"publisher","unstructured":"Singh S, Anshita D, Ravichandiran V (2021) MCP-1: Function, regulation, and involvement in disease. Int Immunopharmacol. 2021 Dec;101(Pt B):107598. https:\/\/doi.org\/10.1016\/j.intimp.2021.107598. Epub 2021 May 20.","DOI":"10.1016\/j.intimp.2021.107598"},{"issue":"8","key":"2294_CR58","doi-asserted-by":"publisher","first-page":"1609","DOI":"10.3390\/polym14081609","volume":"14","author":"LL Siqueira Patriota","year":"2022","unstructured":"Siqueira Patriota LL, Ramos D, E Silva MG, Dos Santos ACLA, Silva YA, Paiva PMG, Pontual EV et al (2022) Inhibition of Carrageenan-Induced Acute Inflammation in Mice by the Microgramma vacciniifolia Frond Lectin (MvFL). Polymers (Basel). 14(8):1609. https:\/\/doi.org\/10.3390\/polym14081609","journal-title":"Polymers (Basel)."},{"issue":"2022","key":"2294_CR59","doi-asserted-by":"publisher","first-page":"5524107","DOI":"10.1155\/2022\/5524107","volume":"13","author":"BP Sousa-Neto","year":"2022","unstructured":"Sousa-Neto BP, Cunha FVM, Nunes DB, Gomes BS, Amorim LV, Lopes EM, Gutierrez SJC, Almeida FRC, Arcanjo DDR, Souza MFV, Oliveira FA (2022) Anti-Inflammatory and Antioxidant Effects of the Indole-Derived N-Salicyloyltryptamine on Peritonitis and Joint Disability Induced by Carrageenan in Rodents. Evid Based Compl Alternat Med 13(2022):5524107. https:\/\/doi.org\/10.1155\/2022\/5524107","journal-title":"Evid Based Compl Alternat Med"},{"issue":"3","key":"2294_CR60","doi-asserted-by":"publisher","first-page":"155932582211198","DOI":"10.1177\/15593258221119877","volume":"20","author":"D Srebro","year":"2022","unstructured":"Srebro D, Rajkovi\u0107 K, Do\u017ei\u0107 B, Vujovi\u0107 KS, Brki\u0107 BM, Mili\u0107 P, Vu\u010dkovi\u0107 S (2022) Investigation of the Antinociceptive Activity of the Hydroethanolic Extract of Junglas nigra Leaf by the Tail-Immersion and Formalin Pain Tests in Rats. Dose Response 20(3):15593258221119876. https:\/\/doi.org\/10.1177\/15593258221119877","journal-title":"Dose Response"},{"issue":"13","key":"2294_CR61","doi-asserted-by":"publisher","first-page":"4260","DOI":"10.3390\/molecules27134260","volume":"27","author":"W Thitinarongwate","year":"2022","unstructured":"Thitinarongwate W, Nimlamool W, Khonsung P, Mektrirat R, Kunanusorn P (2022) Anti- Inflammatory Activity of Essential Oil from Zingiber ottensii Valeton in Animal Models. Molecules 27(13):4260. https:\/\/doi.org\/10.3390\/molecules27134260","journal-title":"Molecules"},{"issue":"6","key":"2294_CR62","doi-asserted-by":"publisher","first-page":"1104","DOI":"10.1002\/jimd.12669","volume":"46","author":"K Vliet","year":"2023","unstructured":"Vliet K, Dijkstra AM, Bouva MJ, van der Krogt J, Bijsterveld K, van der Sluijs F et al (2023) Maleic acid is a biomarker for maleylacetoacetate isomerase deficiency; implications for newborn screening of tyrosinemia type 1. J Inherit Metab Dis 46(6):1104\u20131113. https:\/\/doi.org\/10.1002\/jimd.12669","journal-title":"J Inherit Metab Dis"},{"issue":"3","key":"2294_CR63","doi-asserted-by":"publisher","first-page":"158","DOI":"10.1038\/s41584-021-00738-4","volume":"18","author":"L Wang","year":"2022","unstructured":"Wang L, Luqmani R, Udalova IA (2022) The role of neutrophils in rheumatic disease- associated vascular inflammation. Nat Rev Rheumatol 18(3):158\u2013170. https:\/\/doi.org\/10.1038\/s41584-021-00738-4","journal-title":"Nat Rev Rheumatol"},{"issue":"4","key":"2294_CR64","doi-asserted-by":"publisher","first-page":"218","DOI":"10.1017\/neu.2013.57","volume":"26","author":"Q Zhou","year":"2014","unstructured":"Zhou Q, Bao Y, Zhang X, Zeng L, Wang L, Wang J, Jiang W (2014) Optimal interval for hot water immersion tail-flick test in rats. Acta Neuropsychiatr 26(4):218\u2013222. https:\/\/doi.org\/10.1017\/neu.2013.57","journal-title":"Acta Neuropsychiatr"}],"container-title":["Inflammopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10787-026-02294-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10787-026-02294-3","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10787-026-02294-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T07:16:13Z","timestamp":1784704573000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10787-026-02294-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,12]]},"references-count":64,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2026,7]]}},"alternative-id":["2294"],"URL":"https:\/\/doi.org\/10.1007\/s10787-026-02294-3","relation":{},"ISSN":["0925-4692","1568-5608"],"issn-type":[{"value":"0925-4692","type":"print"},{"value":"1568-5608","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,12]]},"assertion":[{"value":"26 March 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 June 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 June 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. The authors declare no competing interests.","order":1,"name":"Ethics","label":"Conflicts of interest","group":{"name":"EthicsHeading","label":"Declarations"}}]}}