{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T15:09:40Z","timestamp":1788966580138,"version":"build-2803163510"},"reference-count":36,"publisher":"Springer Science and Business Media LLC","issue":"9","license":[{"start":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T00:00:00Z","timestamp":1786924800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T00:00:00Z","timestamp":1786924800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Inflammopharmacol"],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.1007\/s10787-026-02365-5","type":"journal-article","created":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T06:15:31Z","timestamp":1786947331000},"page":"6179-6194","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Evaluation of anti-arthritic activity of aripiprazole through multi models: new potential of an old drug"],"prefix":"10.1007","volume":"34","author":[{"given":"Aroosa","family":"Akber","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"family":"Alamgeer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hafiz Muhammad","family":"Irfan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shoaib","family":"Nawaz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,8,17]]},"reference":[{"issue":"1","key":"2365_CR1","doi-asserted-by":"publisher","first-page":"217","DOI":"10.30848\/PJB2021-1(13)","volume":"53","author":"M Abbas","year":"2021","unstructured":"Abbas M, Ansari MT (2021) Investigation and comparison of anti-inflammatory activities of different extracts of Cymbopogon citratus using various in vivo models. Pak J Bot 53(1):217\u2013226","journal-title":"Pak J Bot"},{"issue":"1","key":"2365_CR2","doi-asserted-by":"publisher","first-page":"217","DOI":"10.30848\/PJB2021-1(13)","volume":"53","author":"M Abbas","year":"2021","unstructured":"Abbas M, Ansari MT, Saeed-Ul-Hassan, Shabbir AJ (2021) Investigation and comparison of anti-inflammatory activities of different extracts of cymbopogon citratus using various in vivo models. Pak J Bot 53(1):217\u2013226","journal-title":"Pak J Bot"},{"key":"2365_CR3","doi-asserted-by":"publisher","first-page":"1","DOI":"10.9734\/JPRI\/2017\/32601","volume":"17","author":"L Adedayo","year":"2017","unstructured":"Adedayo L, Olawuyi D, Ojo A, Bamidele O, Onasanwo S, Ayoka AO (2017) The role of aripiprazole (an anti-psychotic drug) in the resolution of acute peripheral inflammation in male wistar rats. J Pharm Res Int 17:1\u20138","journal-title":"J Pharm Res Int"},{"issue":"1","key":"2365_CR4","doi-asserted-by":"publisher","first-page":"792","DOI":"10.1080\/13880209.2017.1280513","volume":"55","author":"S Alamgeer","year":"2017","unstructured":"Alamgeer S, Niazi SG, Uttra AM, Qaiser MN, Ahsan H (2017) Appraisal of anti-arthritic and nephroprotective potential of Cuscuta reflexa. Pharmaceut Biol 55(1):792\u2013798","journal-title":"Pharmaceut Biol"},{"issue":"05","key":"2365_CR5","first-page":"632","volume":"39","author":"SA Alamgeer","year":"2019","unstructured":"Alamgeer SA, Uttra AM, Hasan UH (2019) Alkaloids, flavonoids, polyphenols might be responsible for potent antiarthritic effect of Solanum nigrum. J Tradit Chin Med 39(05):632","journal-title":"J Tradit Chin Med"},{"issue":"3","key":"2365_CR6","first-page":"1183","volume":"33","author":"S Bashir","year":"2020","unstructured":"Bashir S, Niazi ZR (2020) Appraisal of in vitro, in vivo and multi-targeted molecular docking analysis of atorvastatin to elucidate its anti-arthritic potential. Pak J Pharm Sci 33(3):1183\u20131190","journal-title":"Pak J Pharm Sci"},{"issue":"1","key":"2365_CR7","first-page":"89","volume":"9","author":"IO Ben","year":"2016","unstructured":"Ben IO, Etim OE, Udo NM (2016) Anti-inflammatory effects of Napoleona imperialis P. Beauv (Lecythidaceae) on rat model of inflammation. J Health Sci Biomed Res Kleu 9(1):89","journal-title":"J Health Sci Biomed Res Kleu"},{"key":"2365_CR30","doi-asserted-by":"crossref","unstructured":"Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE (2000) The protein data bank. Nucleic Acids Res 28(1):235\u2013242","DOI":"10.1093\/nar\/28.1.235"},{"issue":"4","key":"2365_CR8","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1097\/00131746-200507000-00004","volume":"11","author":"F Centorrino","year":"2005","unstructured":"Centorrino F, Fogarty KV, Cimbolli P, Salvatore P, Thompson T-A, Sani G, Baldessarini RJ (2005) Aripiprazole: initial clinical experience with 142 hospitalized psychiatric patients. J Psychiatric Pract 11(4):241\u2013247","journal-title":"J Psychiatric Pract"},{"issue":"11","key":"2365_CR9","first-page":"842","volume":"13","author":"X-L Cheng","year":"2015","unstructured":"Cheng X-L, Xin-Guang L, Qi W, Ling Z, Lian-Wen Q, Ping LI (2015) Anti-inflammatory and anti-arthritic effects of Guge fengtong formula: in vitro and in vivo studies. Chin J Nat Med 13(11):842\u2013853","journal-title":"Chin J Nat Med"},{"key":"2365_CR31","doi-asserted-by":"crossref","unstructured":"Feldmann M, Brennan FM, Maini RN (1996) Role of cytokines in rheumatoid arthritis. Ann Rev Immunol 14(1):397\u2013440","DOI":"10.1146\/annurev.immunol.14.1.397"},{"issue":"4","key":"2365_CR10","first-page":"721","volume":"5","author":"K Gautam","year":"2013","unstructured":"Gautam K, Sharma S, Sharma KOMAL (2013) Comparative evaluation of anti-arthritic activity of Pongamia pinnata (Linn.) Pierre and Punica granatum Linn: an in vitro study. Int J Pharm Pharm Sci 5(4):721\u2013724","journal-title":"Int J Pharm Pharm Sci"},{"key":"2365_CR11","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1016\/j.ejphar.2017.07.032","volume":"813","author":"H Gholampour","year":"2017","unstructured":"Gholampour H, Moezi L, Shafaroodi HJE (2017) Aripiprazole prevents renal ischemia\/reperfusion injury in rats, probably through nitric oxide involvement. Eur J Pharmacol 813:17\u201323","journal-title":"Eur J Pharmacol"},{"issue":"7","key":"2365_CR12","doi-asserted-by":"publisher","first-page":"1835","DOI":"10.1111\/j.1476-5381.2009.00468.x","volume":"158","author":"A Gomaa","year":"2009","unstructured":"Gomaa A, Elshenawy M, Afifi N, Mohammed E, Thabit R (2009) Enhancement of the anti-inflammatory and anti-arthritic effects of theophylline by a low dose of a nitric oxide donor or non-specific nitric oxide synthase inhibitor. Br J Pharmacol 158(7):1835\u20131847","journal-title":"Br J Pharmacol"},{"issue":"4","key":"2365_CR13","doi-asserted-by":"publisher","first-page":"807","DOI":"10.3329\/bjp.v10i4.23779","volume":"10","author":"UH Hasan","year":"2015","unstructured":"Hasan UH, Uttra AM, Rasool S (2015) Evaluation of in vitro and in vivo anti-arthritic potential of Berberis calliobotrys. Bangladesh J Pharmacol 10(4):807\u2013819","journal-title":"Bangladesh J Pharmacol"},{"issue":"4","key":"2365_CR14","doi-asserted-by":"publisher","first-page":"781","DOI":"10.1007\/s10787-018-0543-4","volume":"27","author":"UH Hasan","year":"2019","unstructured":"Hasan UH, Shahzad M, Jahan S, Niazi ZR, Bukhari IA, Assiri AM, Riaz HJI (2019) Inhibitory effects of clematis orientalis aqueous ethanol extract and fractions on inflammatory markers in complete freund\u2019s adjuvant-induced arthritis in sprague-dawley rats. Inflammopharmacology 27(4):781\u2013797","journal-title":"Inflammopharmacology"},{"key":"2365_CR32","doi-asserted-by":"crossref","unstructured":"Hevener KE, Zhao W, Ball DM, Babaoglu K, Qi J, White SW, Lee RE (2009) Validation of molecular docking programs for virtual screening against dihydropteroate synthase. J Chem Inf Model 49(2):444\u2013460","DOI":"10.1021\/ci800293n"},{"key":"2365_CR33","doi-asserted-by":"crossref","unstructured":"Irwin JJ, Shoichet BK (2005) ZINC\u2212 a free database of commercially available compounds for virtual screening. J Chem Inf Model 45(1):177\u2013182","DOI":"10.1021\/ci049714+"},{"key":"2365_CR15","doi-asserted-by":"publisher","first-page":"123094","DOI":"10.1155\/2016\/1230294","volume":"2016","author":"W Kim","year":"2016","unstructured":"Kim W, Park S, Choi C, Kim YR, Park I, Seo C (2016) Evaluation of anti-inflammatory potential of the new ganghwaljetongyeum on adjuvant-induced inflammatory arthritis in rats. Evid Based Complement Altern Med 2016:123094","journal-title":"Evid Based Complement Altern Med"},{"issue":"2","key":"2365_CR16","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1177\/1721727X17719600","volume":"15","author":"H Lim","year":"2017","unstructured":"Lim H, Kim HJ, Jeong H, Park H-R (2017) Anti-inflammatory effects of 1-isothiocyanato-7-(methylsulfonyl) heptane by suppressing the NF\u03ba-B signaling pathway. Eur J Inflamm 15(2):57\u201365","journal-title":"Eur J Inflamm"},{"issue":"3","key":"2365_CR17","first-page":"250","volume":"18","author":"DE Masa\u2019il Greenaway","year":"2009","unstructured":"Masa\u2019il Greenaway DE (2009) Focus on aripiprazole: a review of its use in child and adolescent psychiatry. J Can Acad Child Adolescent Psychiatry 18(3):250","journal-title":"J Can Acad Child Adolescent Psychiatry"},{"key":"2365_CR34","doi-asserted-by":"crossref","unstructured":"McInnes IB, Schett G (2007) Cytokines in the pathogenesis of rheumatoid arthritis. Nat Rev Immunol 7(6):429\u2013442","DOI":"10.1038\/nri2094"},{"key":"2365_CR35","doi-asserted-by":"crossref","unstructured":"Morris GM, Huey R, Lindstrom W, Sanner MF, Belew RK, Goodsell DS, Olson AJ (2009) AutoDock4 and AutoDockTools4: automated docking with selective receptor flexibility. J Comput Chem 30(16):2785\u20132791","DOI":"10.1002\/jcc.21256"},{"issue":"2","key":"2365_CR18","first-page":"240","volume":"135","author":"V Nair","year":"2012","unstructured":"Nair V, Singh S, Gupta YK (2012) Evaluation of disease modifying activity of Coriandrum sativum in experimental models. Indian J Med Res 135(2):240","journal-title":"Indian J Med Res"},{"issue":"4","key":"2365_CR19","doi-asserted-by":"publisher","first-page":"447","DOI":"10.3736\/jcim20110415","volume":"9","author":"BV Owoyele","year":"2011","unstructured":"Owoyele BV, Adenekan OT, Soladoye AO (2011) Effects of honey on inflammation and nitric oxide production in Wistar rats. J Chin Integr Med 9(4):447\u2013452","journal-title":"J Chin Integr Med"},{"issue":"4","key":"2365_CR20","doi-asserted-by":"publisher","first-page":"1121","DOI":"10.1007\/s10787-020-00692-9","volume":"28","author":"S Qasim","year":"2020","unstructured":"Qasim S, Kalsoom S, Shahzad M, Irfan HM, Zafar MS, Bukhari IA, Afzal SJI (2020) Appraisal of disease-modifying potential of amlodipine as an anti-arthritic agent: new indication for an old drug. Inflammopharmacology 28(4):1121\u20131136","journal-title":"Inflammopharmacology"},{"issue":"6","key":"2365_CR21","doi-asserted-by":"publisher","first-page":"1918","DOI":"10.1007\/s10753-016-0427-y","volume":"39","author":"A Shabbir","year":"2016","unstructured":"Shabbir A, Shahzad M, Ali A, Zia-ur-Rehman MJI (2016) Discovery of new benzothiazine derivative as modulator of pro-and anti-inflammatory cytokines in rheumatoid arthritis. Inflammation 39(6):1918\u20131929","journal-title":"Inflammation"},{"key":"2365_CR22","doi-asserted-by":"publisher","first-page":"1710","DOI":"10.1016\/j.biopha.2017.11.118","volume":"97","author":"A Shabbir","year":"2018","unstructured":"Shabbir A, Batool SA, Basheer MI, Shahzad M, Sultana K, Tareen RB (2018) Ziziphora clinopodioides ameliorated rheumatoid arthritis and inflammatory paw edema in different models of acute and chronic inflammation. Biomed Pharmacother 97:1710\u20131721","journal-title":"Biomed Pharmacother"},{"key":"2365_CR23","unstructured":"Shaikh PZ (2011) Study of anti-inflammatory activity of ethanolic extract of Hemidesmus indicus roots in acute, subchronic and chronic inflammation in experimental animals. 2:1154\u20131173"},{"issue":"2","key":"2365_CR24","doi-asserted-by":"publisher","first-page":"353","DOI":"10.1016\/j.pharep.2014.09.007","volume":"67","author":"J Sobi\u015b","year":"2015","unstructured":"Sobi\u015b J, Rykaczewska-Czerwi\u0144ska M, \u015awi\u0119tochowska E, Gorczyca P (2015) Therapeutic effect of aripiprazole in chronic schizophrenia is accompanied by anti-inflammatory activity. Pharmacol Rep 67(2):353\u2013359","journal-title":"Pharmacol Rep"},{"key":"2365_CR36","doi-asserted-by":"crossref","unstructured":"\u0160udomov\u00e1 M, Hassan ST, Khan H, Rasekhian M, Nabavi SM (2019) A multi-biochemical and in silico study on anti-enzymatic actions of pyroglutamic acid against PDE-5, ACE, and urease using various analytical techniques: unexplored pharmacological properties and cytotoxicity evaluation. Biomolecules 9(9):392","DOI":"10.3390\/biom9090392"},{"issue":"3","key":"2365_CR25","doi-asserted-by":"publisher","first-page":"S1303","DOI":"10.1016\/S2221-1691(12)60405-5","volume":"2","author":"PB Udavant","year":"2012","unstructured":"Udavant PB, Satyanarayana SV, Upasani CD (2012) Preliminary screening of Cuscuta reflexa stems for anti inflammatory and cytotoxic activity. Asic Pac J Trop Biomed 2(3):S1303\u2013S1307","journal-title":"Asic Pac J Trop Biomed"},{"issue":"1","key":"2365_CR26","first-page":"1","volume":"17","author":"AM Uttra","year":"2017","unstructured":"Uttra AM, Hasan UH (2017) Anti-arthritic activity of aqueous-methanolic extract and various fractions of Berberis orthobotrys Bien ex Aitch. BMC Complement Altern Med 17(1):1\u201316","journal-title":"BMC Complement Altern Med"},{"issue":"1","key":"2365_CR27","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1016\/S0167-5273(02)00237-1","volume":"85","author":"J Walsmith","year":"2002","unstructured":"Walsmith J, Roubenoff R (2002) Cachexia in rheumatoid arthritis. Int J Cardiol 85(1):89\u201399","journal-title":"Int J Cardiol"},{"key":"2365_CR28","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.bcp.2017.12.006","volume":"148","author":"S Yoo","year":"2018","unstructured":"Yoo S, Kim M-Y, Cho JY (2018) Syk and Src-targeted anti-inflammatory activity of aripiprazole, an atypical antipsychotic. Biochem Pharmacol 148:1\u201312","journal-title":"Biochem Pharmacol"},{"issue":"4","key":"2365_CR29","doi-asserted-by":"publisher","first-page":"551","DOI":"10.2217\/pgs.14.25","volume":"15","author":"H Zhu","year":"2014","unstructured":"Zhu H, Deng F-Y, Mo X-B, Qiu Y-H, Lei S-F (2014) Pharmacogenetics and pharmacogenomics for rheumatoid arthritis responsiveness to methotrexate treatment: the 2013 update. Pharmacogenomics 15(4):551\u2013566","journal-title":"Pharmacogenomics"}],"container-title":["Inflammopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10787-026-02365-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10787-026-02365-5","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10787-026-02365-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T14:14:19Z","timestamp":1788963259000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10787-026-02365-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,17]]},"references-count":36,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2026,9]]}},"alternative-id":["2365"],"URL":"https:\/\/doi.org\/10.1007\/s10787-026-02365-5","relation":{"has-preprint":[{"id-type":"doi","id":"10.21203\/rs.3.rs-10139411\/v1","asserted-by":"object"}]},"ISSN":["0925-4692","1568-5608"],"issn-type":[{"value":"0925-4692","type":"print"},{"value":"1568-5608","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,17]]},"assertion":[{"value":"24 June 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 August 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 August 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}