{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T00:40:34Z","timestamp":1792197634022,"version":"4.4.0"},"reference-count":77,"publisher":"Springer Science and Business Media LLC","issue":"10","license":[{"start":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T00:00:00Z","timestamp":1788307200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T00:00:00Z","timestamp":1788307200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Inflammopharmacol"],"published-print":{"date-parts":[[2026,10]]},"DOI":"10.1007\/s10787-026-02383-3","type":"journal-article","created":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T02:55:13Z","timestamp":1788317713000},"page":"6795-6802","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The lithium-magnesium-zinc axis under stress: regulation of N-glycosylation-linked proteostasis and Alzheimer\u2019s disease"],"prefix":"10.1007","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6586-7508","authenticated-orcid":false,"given":"John V.","family":"Schloss","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teresa","family":"Nguyen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,9,2]]},"reference":[{"issue":"8081","key":"2383_CR1","doi-asserted-by":"publisher","first-page":"712","DOI":"10.1038\/s41586-025-09335-xx","volume":"645","author":"L Aron","year":"2025","unstructured":"Aron L, Ngian ZK, Qiu C, Choi J, Liang M, Drake DM, Hamplova SE, Lacey EK, Roche P, Yuan M, Hazaveh SS, Lee EA, Bennett DA, Yankner BA (2025) Lithium deficiency and the onset of Alzheimer\u2019s disease. Nature 645(8081):712\u2013721. https:\/\/doi.org\/10.1038\/s41586-025-09335-xx","journal-title":"Nature"},{"issue":"4558","key":"2383_CR2","doi-asserted-by":"publisher","first-page":"408","DOI":"10.1126\/science.7046051","volume":"217","author":"RT Bartus","year":"1982","unstructured":"Bartus RT, Dean RL 3rd, Beer B, Lippa AS (1982) The cholinergic hypothesis of geriatric memory dysfunction. Science 217(4558):408\u2013414. https:\/\/doi.org\/10.1126\/science.7046051","journal-title":"Science"},{"issue":"1","key":"2383_CR3","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1016\/j.neurobiolaging.2003.03.001","volume":"25","author":"G Bartzokis","year":"2004","unstructured":"Bartzokis G (2004) Age-related myelin breakdown: a developmental model of cognitive decline and Alzheimer\u2019s disease. Neurobiol Aging 25(1):5\u201318. https:\/\/doi.org\/10.1016\/j.neurobiolaging.2003.03.001","journal-title":"Neurobiol Aging"},{"issue":"20","key":"2383_CR4","doi-asserted-by":"publisher","first-page":"9865","DOI":"10.1073\/pnas.1817815116","volume":"116","author":"E Blommaert","year":"2019","unstructured":"Blommaert E, P\u00e9anne R, Cherepanova NA, Rymen D, Staels F, Jaeken J, Race V, Keldermans L, Souche E, Corveleyn A, Sparkes R, Bhattacharya K, Devalck C, Schrijvers R, Foulquier F, Gilmore R, Matthijs G (2019) Mutations in MAGT1 lead to a glycosylation disorder with a variable phenotype. Proc Natl Acad Sci U S A 116(20):9865\u20139870. https:\/\/doi.org\/10.1073\/pnas.1817815116","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"4","key":"2383_CR5","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1016\/s0166-2236(03)00067-5","volume":"26","author":"AI Bush","year":"2003","unstructured":"Bush AI (2003) The metallobiology of Alzheimer\u2019s disease. Trends Neurosci 26(4):207\u2013214. https:\/\/doi.org\/10.1016\/s0166-2236(03)00067-5","journal-title":"Trends Neurosci"},{"issue":"5","key":"2383_CR6","doi-asserted-by":"publisher","first-page":"451","DOI":"10.1016\/0197-4580(89)90096-1","volume":"10","author":"CB Caputo","year":"1989","unstructured":"Caputo CB, Salama AI (1989) The amyloid proteins of Alzheimer\u2019s disease as potential targets for drug therapy. Neurobiol Aging 10(5):451\u2013461. https:\/\/doi.org\/10.1016\/0197-4580(89)90096-1","journal-title":"Neurobiol Aging"},{"issue":"Pt B","key":"2383_CR7","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2025.120504","volume":"393","author":"I Chan","year":"2026","unstructured":"Chan I, Maruff P, Pietrzak RH, Perin S, Lim YY (2026) Association between anxiety, stress, and cognition in middle-aged adults at risk for Alzheimer\u2019s disease: results from the healthy brain project. J Affect Disord 393(Pt B):120504. https:\/\/doi.org\/10.1016\/j.jad.2025.120504","journal-title":"J Affect Disord"},{"issue":"8","key":"2383_CR8","doi-asserted-by":"publisher","first-page":"2782","DOI":"10.1083\/jcb.201904004","volume":"218","author":"NA Cherepanova","year":"2019","unstructured":"Cherepanova NA, Venev SV, Leszyk JD, Shaffer SA, Gilmore R (2019) Quantitative glycoproteomics reveals new classes of STT3A- and STT3B-dependent N-glycosylation sites. J Cell Biol 218(8):2782\u20132796. https:\/\/doi.org\/10.1083\/jcb.201904004","journal-title":"J Cell Biol"},{"issue":"4","key":"2383_CR9","doi-asserted-by":"publisher","first-page":"1877","DOI":"10.1152\/physrev.00018.2018","volume":"99","author":"JF Cryan","year":"2019","unstructured":"Cryan JF, O\u2019Riordan KJ, Cowan CSM, Sandhu KV, Bastiaanssen TFS, Boehme M, Codagnone MG, Cussotto S, Fulling C, Golubeva AV, Guzzetta KE, Jaggar M, Long-Smith CM, Lyte JM, Martin JA, Molinero-Perez A, Moloney G, Morelli E, Morillas E, O\u2019Connor R, Cruz-Pereira JS, Peterson VL, Rea K, Ritz NL, Sherwin E, Spichak S, Teichman EM, van de Wouw M, Ventura-Silva AP, Wallace-Fitzsimons SE, Hyland N, Clarke G, Dinan TG (2019) The microbiota-gut-brain axis. Physiol Rev 99(4):1877\u20132013. https:\/\/doi.org\/10.1152\/physrev.00018.2018","journal-title":"Physiol Rev"},{"issue":"8000","key":"2383_CR10","doi-asserted-by":"publisher","first-page":"1403","DOI":"10.1016\/s0140-6736(76)91936-x","volume":"2","author":"P Davies","year":"1976","unstructured":"Davies P, Maloney AJ (1976) Selective loss of central cholinergic neurons in Alzheimer\u2019s disease. Lancet 2(8000):1403. https:\/\/doi.org\/10.1016\/s0140-6736(76)91936-x","journal-title":"Lancet"},{"issue":"5","key":"2383_CR11","doi-asserted-by":"publisher","first-page":"457","DOI":"10.1002\/ana.410270502","volume":"27","author":"ST DeKosky","year":"1990","unstructured":"DeKosky ST, Scheff SW (1990) Synapse loss in frontal cortex biopsies in Alzheimer\u2019s disease: correlation with cognitive severity. Ann Neurol 27(5):457\u2013464. https:\/\/doi.org\/10.1002\/ana.410270502","journal-title":"Ann Neurol"},{"issue":"14","key":"2383_CR12","doi-asserted-by":"publisher","first-page":"2220","DOI":"10.1091\/mbc.E14-03-0805","volume":"25","author":"D Dersh","year":"2014","unstructured":"Dersh D, Jones B, Argon Y (2014) OS-9 facilitates turnover of nonnative GRP94 marked by hyperglycosylation. Mol Biol Cell 25(14):2220\u20132234. https:\/\/doi.org\/10.1091\/mbc.E14-03-0805","journal-title":"Mol Biol Cell"},{"issue":"12","key":"2383_CR13","doi-asserted-by":"publisher","first-page":"1277","DOI":"10.1093\/glycob\/10.12.1277","volume":"10","author":"T Dupr\u00e9","year":"2000","unstructured":"Dupr\u00e9 T, Barnier A, de Lonlay P, Cormier-Daire V, Durand G, Codogno P, Seta N (2000) Defect in N-glycosylation of proteins is tissue-dependent in congenital disorders of glycosylation Ia. Glycobiology 10(12):1277\u20131281. https:\/\/doi.org\/10.1093\/glycob\/10.12.1277","journal-title":"Glycobiology"},{"issue":"11","key":"2383_CR14","doi-asserted-by":"publisher","first-page":"2490","DOI":"10.1161\/01.ATV.0000242903.41158.a1","volume":"26","author":"PS Gargalovic","year":"2006","unstructured":"Gargalovic PS, Gharavi NM, Clark MJ, Pagnon J, Yang WP, He A, Truong A, Baruch-Oren T, Berliner JA, Kirchgessner TG, Lusis AJ (2006) The unfolded protein response is an important regulator of inflammatory genes in endothelial cells. Arterioscler Thromb Vasc Biol 26(11):2490\u20132496. https:\/\/doi.org\/10.1161\/01.ATV.0000242903.41158.a1","journal-title":"Arterioscler Thromb Vasc Biol"},{"issue":"6355","key":"2383_CR15","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1038\/355033a0","volume":"355","author":"MJ Gething","year":"1992","unstructured":"Gething MJ, Sambrook J (1992) Protein folding in the cell. Nature 355(6355):33\u201345. https:\/\/doi.org\/10.1038\/355033a0","journal-title":"Nature"},{"issue":"3","key":"2383_CR16","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1016\/0306-9877(90)90095-v","volume":"31","author":"JL Glick","year":"1990","unstructured":"Glick JL (1990) Dementias: the role of magnesium deficiency and an hypothesis concerning the pathogenesis of Alzheimer\u2019s disease. Med Hypotheses 31(3):211\u2013225. https:\/\/doi.org\/10.1016\/0306-9877(90)90095-v","journal-title":"Med Hypotheses"},{"issue":"41","key":"2383_CR17","doi-asserted-by":"publisher","first-page":"17698","DOI":"10.1073\/pnas.1011736107","volume":"107","author":"JC Goodall","year":"2010","unstructured":"Goodall JC, Wu C, Zhang Y, McNeill L, Ellis L, Saudek V, Gaston JSH (2010) Endoplasmic reticulum stress-induced transcription factor, CHOP, is crucial for dendritic cell IL-23 expression. Proc Natl Acad Sci U S A 107(41):17698\u201317703. https:\/\/doi.org\/10.1073\/pnas.1011736107","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"2","key":"2383_CR18","doi-asserted-by":"publisher","first-page":"543","DOI":"10.1111\/j.1471-4159.1987.tb04127.x","volume":"48","author":"JT Greenamyre","year":"1987","unstructured":"Greenamyre JT, Penney JB, D\u2019Amato CJ, Young AB (1987) Dementia of the Alzheimer\u2019s type: changes in hippocampal L-[3H]glutamate binding. J Neurochem 48(2):543\u2013551. https:\/\/doi.org\/10.1111\/j.1471-4159.1987.tb04127.x","journal-title":"J Neurochem"},{"issue":"2","key":"2383_CR19","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1056\/NEJMoa1211851","volume":"368","author":"R Guerreiro","year":"2013","unstructured":"Guerreiro R, Wojtas A, Bras J, Carrasquillo M, Rogaeva E, Majounie E, Cruchaga C, Sassi C, Kauwe JS, Younkin S, Hazrati L, Collinge J, Pocock J, Lashley T, Williams J, Lambert JC, Amouyel P, Goate A, Rademakers R, Morgan K, Powell J, St George-Hyslop P, Singleton A, Hardy J, Alzheimer Genetic Analysis Group (2013) TREM2 variants in Alzheimer\u2019s disease. N Engl J Med 368(2):117\u2013127. https:\/\/doi.org\/10.1056\/NEJMoa1211851","journal-title":"N Engl J Med"},{"issue":"1","key":"2383_CR20","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-11947-x","volume":"7","author":"H Guo","year":"2017","unstructured":"Guo H, Camargo LM, Yeboah F, Digan ME, Niu H, Pan Y, Reiling S, Soler-Llavina G, Weihofen WA, Wang HR, Shanker YG, Stams T, Bill A (2017) A NMDA-receptor calcium influx assay sensitive to stimulation by glutamate and glycine\/D-serine. Sci Rep 7(1):11608. https:\/\/doi.org\/10.1038\/s41598-017-11947-x","journal-title":"Sci Rep"},{"issue":"5054","key":"2383_CR21","doi-asserted-by":"publisher","first-page":"184","DOI":"10.1126\/science","volume":"256","author":"JA Hardy","year":"1992","unstructured":"Hardy JA, Higgins GA (1992) Alzheimer\u2019s disease: the amyloid cascade hypothesis. Science 256(5054):184\u2013185. https:\/\/doi.org\/10.1126\/science","journal-title":"Science"},{"issue":"6","key":"2383_CR22","doi-asserted-by":"publisher","first-page":"1410","DOI":"10.1038\/s42255-026-01538-4","volume":"8","author":"TR Hawkinson","year":"2026","unstructured":"Hawkinson TR, Liu Z, Ribas RA, Medina T, Nielsen RS, Clarke HA, Ma X, Mueller AC, Plasencia AF, Sheer AL, Simpson ST, Soto CM, Sudderth J, Cai F, Cantrell AR, Colpaert MG, Shedlock CJ, Wu L, Young LEA, Kooser DD, Chen L, Ryan AM, Quinones S, Son J, Azadi P, Deberardinis RJ, Prokop S, Allison D, Yang S, Chen H, Huang Y, He X, Alonge KM, Guo J, Guo Y, Bian J, Vander Kooi CW, Gentry MS, Sun RC (2026) Hyperglycosylation is a metabolic driver of Alzheimer\u2019s disease. Nat Metab 8(6):1410\u20131425. https:\/\/doi.org\/10.1038\/s42255-026-01538-4","journal-title":"Nat Metab"},{"key":"2383_CR23","doi-asserted-by":"publisher","DOI":"10.1038\/srep03739","volume":"4","author":"P Horak","year":"2014","unstructured":"Horak P, Tomasich E, Va\u0148hara P, Kratochv\u00edlov\u00e1 K, Anees M, Marhold M, Lemberger CE, Gerschpacher M, Horvat R, Sibilia M, Pils D, Krainer M (2014) TUSC3 loss alters the ER stress response and accelerates prostate cancer growth in vivo. Sci Rep 4:3739. https:\/\/doi.org\/10.1038\/srep03739","journal-title":"Sci Rep"},{"issue":"12","key":"2383_CR24","doi-asserted-by":"publisher","first-page":"2319","DOI":"10.1038\/s42255-024-01174-w","volume":"6","author":"LE H\u00f8yland","year":"2024","unstructured":"H\u00f8yland LE, VanLinden MR, Niere M, Str\u00f8mland \u00d8, Sharma S, Dietze J, Tol\u00e5s I, Lucena E, Bifulco E, Sverkeli LJ, Cimadamore-Werthein C, Ashrafi H, Haukanes KF, van der Hoeven B, D\u00f6lle C, Davidsen C, Pettersen IKN, Tronstad KJ, Mj\u00f8s SA, Hayat F, Makarov MV, Migaud ME, Heiland I, Ziegler M (2024) Subcellular NAD+ pools are interconnected and buffered by mitochondrial NAD. Nat Metab 6(12):2319\u20132337. https:\/\/doi.org\/10.1038\/s42255-024-01174-w","journal-title":"Nat Metab"},{"key":"2383_CR25","doi-asserted-by":"publisher","first-page":"256","DOI":"10.1016\/j.bioactmat.2024.10.014","volume":"44","author":"J Huang","year":"2025","unstructured":"Huang J, Xue J, Huang J, Zhang X, Zhang H (2025) An injectable hyaluronic acid\/lithium calcium silicate soft tissue filler with vascularization and collagen regeneration. Bioact Mater 44:256\u2013268. https:\/\/doi.org\/10.1016\/j.bioactmat.2024.10.014","journal-title":"Bioact Mater"},{"key":"2383_CR26","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1017\/UPO9780987073051","volume-title":"Magnesium in the central nervous system","author":"S Iotti","year":"2011","unstructured":"Iotti S, Malucelli E (2011) Free magnesium concentration in the human brain. In: Vink R, Nechifor M (eds) Magnesium in the central nervous system. University of Adelaide Press, Adelaide, pp 3\u201312. https:\/\/doi.org\/10.1017\/UPO9780987073051"},{"issue":"2","key":"2383_CR27","doi-asserted-by":"publisher","DOI":"10.1002\/jimd.70163","volume":"49","author":"A Jain","year":"2026","unstructured":"Jain A, Budhraja R, Garapati K, Lam C, Schultz MJ, Kozicz T, Morava E, Pandey A (2026) Extensive hypoglycosylation of serum N-glycoproteins in SRD5A3 deficiency. J Inherit Metab Dis 49(2):e70163. https:\/\/doi.org\/10.1002\/jimd.70163","journal-title":"J Inherit Metab Dis"},{"issue":"2","key":"2383_CR28","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1056\/NEJMoa1211159","volume":"368","author":"T Jonsson","year":"2013","unstructured":"Jonsson T, Stefansson H, Steinberg S, Jonsdottir I, Jonsson PV, Snaedal J, Bjornsson S, Huttenlocher J, Levey AI, Lah JJ, Rujescu D, Hampel H, Giegling I, Andreassen OA, Engedal K, Ulstein I, Djurovic S, Ibrahim-Verbaas C, Hofman A, Ikram MA, van Duijn CM, Thorsteinsdottir U, Kong A, Stefansson K (2013) Variant of TREM2 associated with the risk of Alzheimer\u2019s disease. N Engl J Med 368(2):107\u2013116. https:\/\/doi.org\/10.1056\/NEJMoa1211159","journal-title":"N Engl J Med"},{"issue":"50","key":"2383_CR29","doi-asserted-by":"publisher","first-page":"51999","DOI":"10.1074\/jbc.M405522200","volume":"279","author":"KH Kim","year":"2004","unstructured":"Kim KH, Song MJ, Yoo EJ, Choe SS, Park SD, Kim JB (2004) Regulatory role of glycogen synthase kinase 3 for transcriptional activity of ADD1\/SREBP1c. J Biol Chem 279(50):51999\u201352006. https:\/\/doi.org\/10.1074\/jbc.M405522200","journal-title":"J Biol Chem"},{"issue":"2","key":"2383_CR30","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1159\/000119431","volume":"23","author":"GK Kirov","year":"1990","unstructured":"Kirov GK, Tsachev KN (1990) Magnesium, schizophrenia and manic-depressive disease. Neuropsychobiology 23(2):79\u201381. https:\/\/doi.org\/10.1159\/000119431","journal-title":"Neuropsychobiology"},{"issue":"5","key":"2383_CR31","doi-asserted-by":"publisher","first-page":"454","DOI":"10.1001\/jamapsychiatry.2022.0337","volume":"79","author":"O K\u00f6hler-Forsberg","year":"2022","unstructured":"K\u00f6hler-Forsberg O, Rohde C, Nierenberg AA, \u00d8stergaard SD (2022) Association of lithium treatment with the risk of osteoporosis in patients with bipolar disorder. JAMA Psychiat 79(5):454\u2013463. https:\/\/doi.org\/10.1001\/jamapsychiatry.2022.0337","journal-title":"JAMA Psychiat"},{"issue":"10","key":"2383_CR32","doi-asserted-by":"publisher","first-page":"535","DOI":"10.1042\/BCJ20240769","volume":"482","author":"L Kohrs","year":"2025","unstructured":"Kohrs L, Buettner FFR, Lokau J, Garbers C (2025) The biology of interleukin-6 family cytokines is regulated by glycosylation. Biochem J 482(10):535\u2013551. https:\/\/doi.org\/10.1042\/BCJ20240769","journal-title":"Biochem J"},{"issue":"11","key":"2383_CR33","doi-asserted-by":"publisher","first-page":"4044","DOI":"10.1073\/pnas.83.11.4044","volume":"83","author":"KS Kosik","year":"1986","unstructured":"Kosik KS, Joachim CL, Selkoe DJ (1986) Microtubule-associated protein tau (tau) is a major antigenic component of paired helical filaments in Alzheimer disease. Proc Natl Acad Sci U S A 83(11):4044\u20134048. https:\/\/doi.org\/10.1073\/pnas.83.11.4044","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"6163","key":"2383_CR34","doi-asserted-by":"publisher","first-page":"462","DOI":"10.1038\/332462a0","volume":"332","author":"Y Kozutsumi","year":"1988","unstructured":"Kozutsumi Y, Segal MS, Normington K, Gething MJ, Sambrook J (1988) The presence of malfolded proteins in the endoplasmic reticulum signals the induction of glucose-regulated proteins. Nature 332(6163):462\u2013464. https:\/\/doi.org\/10.1038\/332462a0","journal-title":"Nature"},{"issue":"6","key":"2383_CR35","doi-asserted-by":"publisher","first-page":"688","DOI":"10.1038\/s41593-022-01084-8","volume":"25","author":"JH Lee","year":"2022","unstructured":"Lee JH, Yang DS, Goulbourne CN, Im E, Stavrides P, Pensalfini A, Chan H, Bouchet-Marquis C, Bleiwas C, Berg MJ, Huo C, Peddy J, Pawlik M, Levy E, Rao M, Staufenbiel M, Nixon RA (2022) Faulty autolysosome acidification in Alzheimer\u2019s disease mouse models induces autophagic build-up of A\u03b2 in neurons, yielding senile plaques. Nat Neurosci 25(6):688\u2013701. https:\/\/doi.org\/10.1038\/s41593-022-01084-8","journal-title":"Nat Neurosci"},{"issue":"3","key":"2383_CR36","doi-asserted-by":"publisher","first-page":"693","DOI":"10.1111\/j.1432-1033.1993.tb17707.x","volume":"212","author":"AP Leech","year":"1993","unstructured":"Leech AP, Baker GR, Shute JK, Cohen MA, Gani D (1993) Chemical and kinetic mechanism of the inositol monophosphatase reaction and its inhibition by Li+. Eur J Biochem 212(3):693\u2013704. https:\/\/doi.org\/10.1111\/j.1432-1033.1993.tb17707.x","journal-title":"Eur J Biochem"},{"issue":"5226","key":"2383_CR37","doi-asserted-by":"publisher","first-page":"973","DOI":"10.1126\/science.7638622","volume":"269","author":"E Levy-Lahad","year":"1995","unstructured":"Levy-Lahad E, Wasco W, Poorkaj P, Romano DM, Oshima J, Pettingell WH, Yu CE, Jondro PD, Schmidt SD, Wang K et al (1995) Candidate gene for the chromosome 1 familial Alzheimer\u2019s disease locus. Science 269(5226):973\u2013977. https:\/\/doi.org\/10.1126\/science.7638622","journal-title":"Science"},{"issue":"10","key":"2383_CR38","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2026608118","volume":"118","author":"RC Li","year":"2021","unstructured":"Li RC, Wong MY, DiChiara AS, Hosseini AS, Shoulders MD (2021) Collagen\u2019s enigmatic, highly conserved N-glycan has an essential proteostatic function. Proc Natl Acad Sci U S A 118(10):e2026608118. https:\/\/doi.org\/10.1073\/pnas.2026608118","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"29","key":"2383_CR39","doi-asserted-by":"publisher","first-page":"10804","DOI":"10.1073\/pnas.0400348101","volume":"101","author":"F Liu","year":"2004","unstructured":"Liu F, Iqbal K, Grundke-Iqbal I, Hart GW, Gong CX (2004) O-GlcNAcylation regulates phosphorylation of tau: a mechanism involved in Alzheimer\u2019s disease. Proc Natl Acad Sci U S A 101(29):10804\u201310809. https:\/\/doi.org\/10.1073\/pnas.0400348101","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2383_CR40","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyt.2024.1431942","volume":"15","author":"Y Lv","year":"2024","unstructured":"Lv Y, Chen Y, Li X, Huang Q, Lu R, Ye J, Meng W, Fan C, Mo X (2024) Predicting psychiatric risk: IgG N-glycosylation traits as biomarkers for mental health. Front Psychiatry 15:1431942. https:\/\/doi.org\/10.3389\/fpsyt.2024.1431942","journal-title":"Front Psychiatry"},{"key":"2383_CR41","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrep.2026.102640","volume":"46","author":"LS Mahl","year":"2026","unstructured":"Mahl LS, Meyer AH (2026) Genomic insights into the tunicamycin-induced endoplasmic reticulum stress response in peripheral blood mononuclear cells: a comprehensive RNA sequencing analysis. Biochem Biophys Rep 46:102640. https:\/\/doi.org\/10.1016\/j.bbrep.2026.102640","journal-title":"Biochem Biophys Rep"},{"issue":"1","key":"2383_CR42","doi-asserted-by":"publisher","first-page":"134","DOI":"10.1016\/s0891-5849(96)00629-6","volume":"23","author":"WR Markesbery","year":"1997","unstructured":"Markesbery WR (1997) Oxidative stress hypothesis in Alzheimer\u2019s disease. Free Radic Biol Med 23(1):134\u2013147. https:\/\/doi.org\/10.1016\/s0891-5849(96)00629-6","journal-title":"Free Radic Biol Med"},{"issue":"37","key":"2383_CR43","doi-asserted-by":"publisher","first-page":"13638","DOI":"10.1074\/jbc.RA119.008903","volume":"294","author":"M Matsuda-Lennikov","year":"2019","unstructured":"Matsuda-Lennikov M, Biancalana M, Zou J, Ravell JC, Zheng L, Kanellopoulou C, Jiang P, Notarangelo G, Jing H, Masutani E, Oler AJ, Olano LR, Schulz BL, Lenardo MJ (2019) Magnesium transporter 1 (MAGT1) deficiency causes selective defects in N-linked glycosylation and expression of immune-response genes. J Biol Chem 294(37):13638\u201313656. https:\/\/doi.org\/10.1074\/jbc.RA119.008903","journal-title":"J Biol Chem"},{"issue":"1","key":"2383_CR44","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1038\/ng0597-88","volume":"16","author":"G Matthijs","year":"1997","unstructured":"Matthijs G, Schollen E, Pardon E, Veiga-Da-Cunha M, Jaeken J, Cassiman JJ, Van Schaftingen E (1997) Mutations in PMM2, a phosphomannomutase gene on chromosome 16p13, in carbohydrate-deficient glycoprotein type I syndrome (Jaeken syndrome). Nat Genet 16(1):88\u201392. https:\/\/doi.org\/10.1038\/ng0597-88","journal-title":"Nat Genet"},{"issue":"2","key":"2383_CR45","doi-asserted-by":"publisher","first-page":"296","DOI":"10.1016\/j.neuron.2014.12.032","volume":"85","author":"A Montagne","year":"2015","unstructured":"Montagne A, Barnes SR, Sweeney MD, Halliday MR, Sagare AP, Zhao Z, Toga AW, Jacobs RE, Liu CY, Amezcua L, Harrington MG, Chui HC, Law M, Zlokovic BV (2015) Blood-brain barrier breakdown in the aging human hippocampus. Neuron 85(2):296\u2013302. https:\/\/doi.org\/10.1016\/j.neuron.2014.12.032","journal-title":"Neuron"},{"issue":"10","key":"2383_CR46","doi-asserted-by":"publisher","first-page":"e320","DOI":"10.1038\/tp.2013.93","volume":"3","author":"M Moreno-Villanueva","year":"2013","unstructured":"Moreno-Villanueva M, Morath J, Vanhooren V, Elbert T, Kolassa S, Libert C, B\u00fcrkle A, Kolassa IT (2013) N-glycosylation profiling of plasma provides evidence for accelerated physiological aging in post-traumatic stress disorder. Transl Psychiatry 3(10):e320. https:\/\/doi.org\/10.1038\/tp.2013.93","journal-title":"Transl Psychiatry"},{"issue":"7","key":"2383_CR47","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0070410","volume":"8","author":"T Nagy","year":"2013","unstructured":"Nagy T, Frank D, K\u00e1tai E, Yahiro RK, Po\u00f3r VS, Montsk\u00f3 G, Zr\u00ednyi Z, Kov\u00e1cs GL, Miseta A (2013) Lithium induces ER stress and N-glycan modification in galactose-grown Jurkat cells. PLoS ONE 8(7):e70410. https:\/\/doi.org\/10.1371\/journal.pone.0070410","journal-title":"PLoS ONE"},{"issue":"23","key":"2383_CR48","doi-asserted-by":"publisher","DOI":"10.3390\/nu17233662","volume":"17","author":"DJ Nelson","year":"2025","unstructured":"Nelson DJ, Rosanoff A, von Ehrlich B (2025) Novel scale for clinical identification of adverse magnesium\/calcium imbalances: applications and perspectives. Nutrients 17(23):3662. https:\/\/doi.org\/10.3390\/nu17233662","journal-title":"Nutrients"},{"issue":"8","key":"2383_CR49","doi-asserted-by":"publisher","DOI":"10.1002\/alz.70497","volume":"21","author":"AG Palacios","year":"2025","unstructured":"Palacios AG, Zhang SX, Acosta M (2025) Diabetic retinopathy and Alzheimer\u2019s disease: convergence of the unfolded protein response in neurodegeneration. Alzheimers Dement 21(8):e70497. https:\/\/doi.org\/10.1002\/alz.70497","journal-title":"Alzheimers Dement"},{"issue":"1","key":"2383_CR50","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-025-65668-1","volume":"16","author":"G Park","year":"2025","unstructured":"Park G, Kim N, Kim SY, Lee H, Li CM, Seol JH, Choi SY, Jung YK (2025) TUSC3 regulates ERMA-mediated Mg2+ uptake for synaptic function and neurodevelopment. Nat Commun 16(1):9752. https:\/\/doi.org\/10.1038\/s41467-025-65668-1","journal-title":"Nat Commun"},{"issue":"4441","key":"2383_CR51","doi-asserted-by":"publisher","first-page":"297","DOI":"10.1126\/science.7367858","volume":"208","author":"DP Perl","year":"1980","unstructured":"Perl DP, Brody AR (1980) Alzheimer\u2019s disease: X-ray spectrometric evidence of aluminum accumulation in neurofibrillary tangle-bearing neurons. Science 208(4441):297\u2013299. https:\/\/doi.org\/10.1126\/science.7367858","journal-title":"Science"},{"issue":"12","key":"2383_CR52","doi-asserted-by":"publisher","DOI":"10.3390\/nu12123672","volume":"12","author":"G Pickering","year":"2020","unstructured":"Pickering G, Mazur A, Trousselard M, Bienkowski P, Yaltsewa N, Amessou M, Noah L, Pouteau E (2020) Magnesium status and stress: the vicious circle concept revisited. Nutrients 12(12):3672. https:\/\/doi.org\/10.3390\/nu12123672","journal-title":"Nutrients"},{"issue":"16","key":"2383_CR53","doi-asserted-by":"publisher","first-page":"9398","DOI":"10.1074\/jbc.271.16.9398","volume":"271","author":"A Pirskanen","year":"1996","unstructured":"Pirskanen A, Kaimio AM, Myllyl\u00e4 R, Kivirikko KI (1996) Site-directed Mutagenesis of Human Lysyl Hydroxylase Expressed in Insect Cells: identification of histidine residues and an aspartic acid residue critical for catalytic activity (\u2217). J Biol Chem 271(16):9398\u20139402. https:\/\/doi.org\/10.1074\/jbc.271.16.9398","journal-title":"J Biol Chem"},{"issue":"3","key":"2383_CR54","doi-asserted-by":"publisher","first-page":"1039","DOI":"10.1021\/acs.jproteome.4c00655","volume":"24","author":"P Ren","year":"2025","unstructured":"Ren P, Fu L, Gong X, Jia L, Lyu B, Wang M, Zhang S, Sun S, Zhao N, Xu Z, Zhu J (2025) Heterogeneities of site-specific N-glycosylation in the hippocampus of depression-like behavior models in mice induced by acute stress and chronic stress. J Proteome Res 24(3):1039\u20131052. https:\/\/doi.org\/10.1021\/acs.jproteome.4c00655","journal-title":"J Proteome Res"},{"issue":"23","key":"2383_CR55","doi-asserted-by":"publisher","first-page":"3671","DOI":"10.3390\/nu17233671","volume":"17","author":"A Rosanoff","year":"2025","unstructured":"Rosanoff A, von Ehrlich B, Nelson B (2025) A proposed scale to assess magnesium status using serum calcium and magnesium ratios. Nutrients 17(23):3671. https:\/\/doi.org\/10.3390\/nu17233671","journal-title":"Nutrients"},{"issue":"3","key":"2383_CR56","doi-asserted-by":"publisher","first-page":"720","DOI":"10.1006\/bbrc.2000.4169","volume":"280","author":"WJ Ryves","year":"2001","unstructured":"Ryves WJ, Harwood AJ (2001) Lithium inhibits glycogen synthase kinase-3 by competition for magnesium. Biochem Biophys Res Commun 280(3):720\u2013725. https:\/\/doi.org\/10.1006\/bbrc.2000.4169","journal-title":"Biochem Biophys Res Commun"},{"issue":"29","key":"2383_CR57","doi-asserted-by":"publisher","first-page":"15413","DOI":"10.1016\/S0021-9258(17)36269-5","volume":"260","author":"Y Sakakihara","year":"1985","unstructured":"Sakakihara Y, Volpe JJ (1985) Zn2+, not Ca2+, is the most effective cation for activation of dolichol kinase of mammalian brain. J Biol Chem 260(29):15413\u2013154139. https:\/\/doi.org\/10.1016\/S0021-9258(17)36269-5","journal-title":"J Biol Chem"},{"issue":"7","key":"2383_CR58","doi-asserted-by":"publisher","first-page":"1101","DOI":"10.1083\/jcb.200504035","volume":"170","author":"S Sarkar","year":"2005","unstructured":"Sarkar S, Floto RA, Berger Z, Imarisio S, Cordenier A, Pasco M, Cook LJ, Rubinsztein DC (2005) Lithium induces autophagy by inhibiting inositol monophosphatase. J Cell Biol 170(7):1101\u20131111. https:\/\/doi.org\/10.1083\/jcb.200504035","journal-title":"J Cell Biol"},{"key":"2383_CR59","doi-asserted-by":"publisher","DOI":"10.1016\/j.biotechadv.2024.108467","volume":"77","author":"G Scapin","year":"2024","unstructured":"Scapin G, \u00c7agdas E, Grav LM, Lewis NE, Goletz S, Hafkenscheid L (2024) Implications of glycosylation for the development of selected cytokines and their derivatives for medical use. Biotechnol Adv 77:108467. https:\/\/doi.org\/10.1016\/j.biotechadv.2024.108467","journal-title":"Biotechnol Adv"},{"issue":"8","key":"2383_CR60","doi-asserted-by":"publisher","first-page":"4651","DOI":"10.1007\/s10787-025-01868-x","volume":"33","author":"JV Schloss","year":"2025","unstructured":"Schloss JV (2025) Is dolichol pathway dysfunction a significant factor in Alzheimer\u2019s disease? Inflammopharmacology 33(8):4651\u20134658. https:\/\/doi.org\/10.1007\/s10787-025-01868-x","journal-title":"Inflammopharmacology"},{"issue":"5","key":"2383_CR61","doi-asserted-by":"publisher","first-page":"429","DOI":"10.1080\/07315724.1994.10718432","volume":"13","author":"MS Seelig","year":"1994","unstructured":"Seelig MS (1994) Consequences of magnesium deficiency on the enhancement of stress reactions; preventive and therapeutic implications. J Am Coll Nutr 13(5):429\u2013446. https:\/\/doi.org\/10.1080\/07315724.1994.10718432","journal-title":"J Am Coll Nutr"},{"issue":"41","key":"2383_CR62","doi-asserted-by":"publisher","first-page":"31164","DOI":"10.1074\/jbc.M110.149195","volume":"285","author":"PK Sengupta","year":"2010","unstructured":"Sengupta PK, Bouchie MP, Kukuruzinska MA (2010) N-glycosylation gene DPAGT1 is a target of the Wnt\/beta-catenin signaling pathway. J Biol Chem 285(41):31164\u201331173. https:\/\/doi.org\/10.1074\/jbc.M110.149195","journal-title":"J Biol Chem"},{"issue":"Pt 2","key":"2383_CR63","doi-asserted-by":"publisher","first-page":"484","DOI":"10.1242\/jcs.113035","volume":"126","author":"PK Sengupta","year":"2013","unstructured":"Sengupta PK, Bouchie MP, Nita-Lazar M, Yang HY, Kukuruzinska MA (2013) Coordinate regulation of N-glycosylation gene DPAGT1, canonical Wnt signaling and E-cadherin adhesion. J Cell Sci 126(Pt 2):484\u2013496. https:\/\/doi.org\/10.1242\/jcs.113035","journal-title":"J Cell Sci"},{"issue":"6534","key":"2383_CR64","doi-asserted-by":"publisher","first-page":"754","DOI":"10.1038\/375754a0","volume":"375","author":"R Sherrington","year":"1995","unstructured":"Sherrington R, Rogaev EI, Liang Y, Rogaeva EA, Levesque G, Ikeda M, Chi H, Lin C, Li G, Holman K, Tsuda T, Mar L, Foncin JF, Bruni AC, Montesi MP, Sorbi S, Rainero I, Pinessi L, Nee L, Chumakov I, Pollen D, Brookes A, Sanseau P, Polinsky RJ, Wasco W, Da Silva HA, Haines JL, Perkicak-Vance MA, Tanzi RE, Roses AD, Fraser PE, Rommens JM, St George-Hyslop PH (1995) Cloning of a gene bearing missense mutations in early-onset familial Alzheimer\u2019s disease. Nature 375(6534):754\u2013760. https:\/\/doi.org\/10.1038\/375754a0","journal-title":"Nature"},{"issue":"17","key":"2383_CR65","doi-asserted-by":"publisher","first-page":"3449","DOI":"10.1007\/s00018-019-03081-w","volume":"76","author":"R Shi","year":"2019","unstructured":"Shi R, Hu W, Zhang Y, Gao S, Smith AH, Ye J, Cai L, Graham LM, Li C (2019) Ascorbate inducible N259 glycans on prolyl 4-hydroxylase subunit \u03b11 promote hydroxylation and secretion of type I collagen. Cell Mol Life Sci 76(17):3449\u20133464. https:\/\/doi.org\/10.1007\/s00018-019-03081-w","journal-title":"Cell Mol Life Sci"},{"issue":"3","key":"2383_CR66","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0009505","volume":"5","author":"SJ Soscia","year":"2010","unstructured":"Soscia SJ, Kirby JE, Washicosky KJ, Tucker SM, Ingelsson M, Hyman B, Burton MA, Goldstein LE, Duong S, Tanzi RE, Moir RD (2010) The Alzheimer\u2019s disease-associated amyloid beta-protein is an antimicrobial peptide. PLoS ONE 5(3):e9505. https:\/\/doi.org\/10.1371\/journal.pone.0009505","journal-title":"PLoS ONE"},{"issue":"5","key":"2383_CR67","doi-asserted-by":"publisher","first-page":"1977","DOI":"10.1073\/pnas.90.5.1977","volume":"90","author":"WJ Strittmatter","year":"1993","unstructured":"Strittmatter WJ, Saunders AM, Schmechel D, Pericak-Vance M, Enghild J, Salvesen GS, Roses AD (1993) Apolipoprotein E: high-avidity binding to beta-amyloid and increased frequency of type 4 allele in late-onset familial Alzheimer disease. PNAS 90(5):1977\u20131981. https:\/\/doi.org\/10.1073\/pnas.90.5.1977","journal-title":"PNAS"},{"issue":"2","key":"2383_CR68","doi-asserted-by":"publisher","first-page":"363","DOI":"10.1016\/j.kint.2019.02.015","volume":"96","author":"CC Sung","year":"2019","unstructured":"Sung CC, Chen L, Limbutara K, Jung HJ, Gilmer GG, Yang CR, Lin SH, Khositseth S, Chou CL, Knepper MA (2019) RNA-Seq and protein mass spectrometry in microdissected kidney tubules reveal signaling processes initiating lithium-induced nephrogenic diabetes insipidus. Kidney Int 96(2):363\u2013377. https:\/\/doi.org\/10.1016\/j.kint.2019.02.015","journal-title":"Kidney Int"},{"issue":"1","key":"2383_CR69","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1016\/j.mehy.2003.12.045","volume":"63","author":"RH Swerdlow","year":"2004","unstructured":"Swerdlow RH, Khan SM (2004) A \u201cmitochondrial cascade hypothesis\u201d for sporadic Alzheimer\u2019s disease. Med Hypotheses 63(1):8\u201320. https:\/\/doi.org\/10.1016\/j.mehy.2003.12.045","journal-title":"Med Hypotheses"},{"issue":"1","key":"2383_CR70","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1007\/s12011-013-9762-0","volume":"155","author":"L Tao","year":"2013","unstructured":"Tao L, Zheng Y, Shen Z, Li Y, Tian X, Dou X, Qian J, Shen H (2013) Psychological stress-induced lower serum zinc and zinc redistribution in rats. Biol Trace Elem Res 155(1):65\u201371. https:\/\/doi.org\/10.1007\/s12011-013-9762-0","journal-title":"Biol Trace Elem Res"},{"key":"2383_CR71","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1186\/1471-230X-14-32","volume":"14","author":"X Tian","year":"2014","unstructured":"Tian X, Zheng Y, Li Y, Shen Z, Tao L, Dou X, Qian J, Shen H (2014) Psychological stress induced zinc accumulation and up-regulation of ZIP14 and metallothionein in rat liver. BMC Gastroenterol 14:32. https:\/\/doi.org\/10.1186\/1471-230X-14-32","journal-title":"BMC Gastroenterol"},{"key":"2383_CR72","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmet.2026.102400","volume":"110","author":"N Very","year":"2026","unstructured":"Very N, El Yazidi-Belkoura I (2026) Cross-talk between glycosylation pathways: mechanistic insights and implications for human diseases. Mol Metab 110:102400. https:\/\/doi.org\/10.1016\/j.molmet.2026.102400","journal-title":"Mol Metab"},{"issue":"2","key":"2383_CR73","first-page":"203","volume":"11","author":"JC Wallwork","year":"1987","unstructured":"Wallwork JC (1987) Zinc and the central nervous system. Prog Food Nutr Sci 11(2):203\u2013247","journal-title":"Prog Food Nutr Sci"},{"issue":"8","key":"2383_CR74","doi-asserted-by":"publisher","first-page":"871","DOI":"10.1038\/nm0896-871","volume":"2","author":"JZ Wang","year":"1996","unstructured":"Wang JZ, Grundke-Iqbal I, Iqbal K (1996) Glycosylation of microtubule-associated protein tau: an abnormal posttranslational modification in Alzheimer\u2019s disease. Nat Med 2(8):871\u2013875. https:\/\/doi.org\/10.1038\/nm0896-871","journal-title":"Nat Med"},{"issue":"12","key":"2383_CR75","doi-asserted-by":"publisher","first-page":"2148","DOI":"10.1016\/j.cell.2022.04.011","volume":"185","author":"A Weiss","year":"2022","unstructured":"Weiss A, Murdoch CC, Edmonds KA, Jordan MR, Monteith AJ, Perera YR, Rodr\u00edguez Nassif AM, Petoletti AM, Beavers WN, Munneke MJ, Drury SL, Krystofiak ES, Thalluri K, Wu H, Kruse ARS, DiMarchi RD, Caprioli RM, Spraggins JM, Chazin WJ, Giedroc DP, Skaar EP (2022) Zn regulated GTPase metalloprotein activator 1 modulates vertebrate zinc homeostasis. Cell 185(12):2148-2163.e27. https:\/\/doi.org\/10.1016\/j.cell.2022.04.011","journal-title":"Cell"},{"issue":"4","key":"2383_CR76","first-page":"213","volume":"3","author":"LS Wolfe","year":"1985","unstructured":"Wolfe LS, Ng Ying Kin NMK, Palo J, Bergeron C, Kotila M, Varonen S (1985) Dolichols are elevated in brain tissue from Alzheimer\u2019s disease, but not in urinary sediment from Alzheimer\u2019s disease and Down\u2019s syndrome. Neurochem Pathol 3(4):213\u2013221","journal-title":"Neurochem Pathol"},{"issue":"3","key":"2383_CR77","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1038\/s41594-018-0031-y","volume":"25","author":"J Yoo","year":"2018","unstructured":"Yoo J, Mashalidis EH, Kuk ACY, Yamamoto K, Kaeser B, Ichikawa S, Lee SY (2018) GlcNAc-1-P-transferase-tunicamycin complex structure reveals basis for inhibition of N-glycosylation. Nat Struct Mol Biol 25(3):217\u2013224. https:\/\/doi.org\/10.1038\/s41594-018-0031-y","journal-title":"Nat Struct Mol Biol"}],"container-title":["Inflammopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10787-026-02383-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10787-026-02383-3","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10787-026-02383-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T23:55:26Z","timestamp":1792194926000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10787-026-02383-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,2]]},"references-count":77,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2026,10]]}},"alternative-id":["2383"],"URL":"https:\/\/doi.org\/10.1007\/s10787-026-02383-3","relation":{},"ISSN":["0925-4692","1568-5608"],"issn-type":[{"value":"0925-4692","type":"print"},{"value":"1568-5608","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,2]]},"assertion":[{"value":"1 May 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 August 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 September 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors have no relevant financial or non-financial interests to disclose.","order":1,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Declarations"}}]}}