{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T00:40:37Z","timestamp":1792197637192,"version":"4.4.0"},"reference-count":91,"publisher":"Springer Science and Business Media LLC","issue":"10","license":[{"start":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T00:00:00Z","timestamp":1788307200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T00:00:00Z","timestamp":1788307200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Inflammopharmacol"],"published-print":{"date-parts":[[2026,10]]},"DOI":"10.1007\/s10787-026-02390-4","type":"journal-article","created":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T15:51:21Z","timestamp":1788364281000},"page":"6363-6388","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Curcumin as a natural therapeutic agent for osteoarthritis: molecular mechanisms, preclinical evidence, clinical applications, and future perspectives"],"prefix":"10.1007","volume":"34","author":[{"given":"Nalina","family":"Viswanathan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vidhyavathi","family":"Ramasamy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,9,2]]},"reference":[{"issue":"7","key":"2390_CR1","doi-asserted-by":"publisher","first-page":"6405","DOI":"10.3390\/ijms24076405","volume":"24","author":"R Giorgino","year":"2023","unstructured":"Giorgino R, Albano D, Fusco S, Peretti GM, Mangiavini L, Messina C (2023) Osteoarthritis: epidemiology, pathogenesis, and mesenchymal stem cells: what else is new? An update. Int J Mol Sci 24(7):6405. https:\/\/doi.org\/10.3390\/ijms24076405","journal-title":"Int J Mol Sci"},{"issue":"6","key":"2390_CR2","doi-asserted-by":"publisher","first-page":"503","DOI":"10.4062\/biomolther.2019.139","volume":"27","author":"YH Kang","year":"2019","unstructured":"Kang YH, Lee HJ, Lee CJ, Park JS (2019) Natural products as sources of novel drug candidates for the pharmacological management of osteoarthritis: a narrative review. Biomol Ther 27(6):503\u2013513. https:\/\/doi.org\/10.4062\/biomolther.2019.139","journal-title":"Biomol Ther"},{"issue":"2","key":"2390_CR3","doi-asserted-by":"publisher","DOI":"10.1016\/j.berh.2023.101836","volume":"37","author":"WJ Scheuing","year":"2023","unstructured":"Scheuing WJ, Reginato AM, Deeb M, Acer Kasman S (2023) The burden of osteoarthritis: is it a rising problem? Best Pract Res Clin Rheumatol 37(2):101836. https:\/\/doi.org\/10.1016\/j.berh.2023.101836","journal-title":"Best Pract Res Clin Rheumatol"},{"issue":"6","key":"2390_CR4","doi-asserted-by":"publisher","first-page":"681","DOI":"10.1111\/joim.13634","volume":"293","author":"M Englund","year":"2023","unstructured":"Englund M (2023) Osteoarthritis, part of life or a curable disease? A bird\u2019s-eye view. J Intern Med 293(6):681\u2013693. https:\/\/doi.org\/10.1111\/joim.13634","journal-title":"J Intern Med"},{"issue":"2","key":"2390_CR5","doi-asserted-by":"publisher","first-page":"222","DOI":"10.1007\/s12016-022-08941-1","volume":"64","author":"F Motta","year":"2023","unstructured":"Motta F, Barone E, Sica A, Selmi C (2023) Inflammaging and osteoarthritis. Clin Rev Allergy Immunol 64(2):222\u2013238. https:\/\/doi.org\/10.1007\/s12016-022-08941-1","journal-title":"Clin Rev Allergy Immunol"},{"issue":"1","key":"2390_CR6","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-023-01330-w","volume":"8","author":"Q Yao","year":"2023","unstructured":"Yao Q, Wu X, Tao C, Gong W, Chen M, Qu M et al (2023) Osteoarthritis: pathogenic signaling pathways and therapeutic targets. Signal Transduct Target Ther 8(1):56. https:\/\/doi.org\/10.1038\/s41392-023-01330-w","journal-title":"Signal Transduct Target Ther"},{"issue":"2","key":"2390_CR7","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1038\/s41584-021-00724-w","volume":"18","author":"T Hodgkinson","year":"2022","unstructured":"Hodgkinson T, Kelly DC, Curtin CM, O\u2019Brien FJ (2022) Mechanosignalling in cartilage: an emerging target for the treatment of osteoarthritis. Nat Rev Rheumatol 18(2):67\u201384. https:\/\/doi.org\/10.1038\/s41584-021-00724-w","journal-title":"Nat Rev Rheumatol"},{"key":"2390_CR8","doi-asserted-by":"publisher","first-page":"1060721","DOI":"10.3389\/fendo.2022.1060721","volume":"13","author":"R Lu","year":"2022","unstructured":"Lu R, He Z, Zhang W, Wang Y, Cheng P, Lv Z et al (2022) Oroxin B alleviates Osteoarthritis through anti-inflammation and inhibition of the PI3K\/AKT\/mTOR signaling pathway and enhancement of autophagy. Front Endocrinol 13:1060721. https:\/\/doi.org\/10.3389\/fendo.2022.1060721","journal-title":"Front Endocrinol"},{"key":"2390_CR9","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2024.116194","volume":"171","author":"X Deng","year":"2024","unstructured":"Deng X, Qu Y, Li M, Wu C, Dai J, Wei K et al (2024a) Sakuranetin reduces inflammation and chondrocyte dysfunction in osteoarthritis by inhibiting the PI3K\/AKT\/NF-\u03baB pathway. Biomed Pharmacother 171:116194. https:\/\/doi.org\/10.1016\/j.biopha.2024.116194","journal-title":"Biomed Pharmacother"},{"issue":"6","key":"2390_CR10","doi-asserted-by":"publisher","first-page":"1653","DOI":"10.1007\/s10787-021-00888-7","volume":"29","author":"MA Abdel-Aziz","year":"2021","unstructured":"Abdel-Aziz MA, Ahmed HMS, El-Nekeety AA, Abdel-Wahhab MA (2021) Osteoarthritis complications and the recent therapeutic approaches. Inflammopharmacology 29(6):1653\u20131667. https:\/\/doi.org\/10.1007\/s10787-021-00888-7","journal-title":"Inflammopharmacology"},{"issue":"11","key":"2390_CR11","doi-asserted-by":"publisher","first-page":"1689","DOI":"10.1038\/s12276-021-00710-y","volume":"53","author":"Y Cho","year":"2021","unstructured":"Cho Y, Jeong S, Kim H, Kang D, Lee J, Kang SB et al (2021) Disease-modifying therapeutic strategies in osteoarthritis: current status and future directions. Exp Mol Med 53(11):1689\u20131696. https:\/\/doi.org\/10.1038\/s12276-021-00710-y","journal-title":"Exp Mol Med"},{"issue":"4","key":"2390_CR12","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2024.e26289","volume":"10","author":"Q Zhou","year":"2024","unstructured":"Zhou Q, Liu J, Xin L, Fang Y, Hu Y, Qi Y et al (2024) Association between traditional Chinese medicine and osteoarthritis outcome: a 5-year matched cohort study. Heliyon 10(4):e26289. https:\/\/doi.org\/10.1016\/j.heliyon.2024.e26289","journal-title":"Heliyon"},{"issue":"1","key":"2390_CR13","doi-asserted-by":"publisher","DOI":"10.1186\/s13018-023-03570-6","volume":"18","author":"W Wang","year":"2023","unstructured":"Wang W, Shi H, Liu Y, Sun Y, Chen Y, Liu Z (2023a) Efficacy and safety of acupuncture for hand osteoarthritis: study protocol for a multicenter, randomized, sham-controlled clinical trial. J Orthop Surg Res 18(1):89. https:\/\/doi.org\/10.1186\/s13018-023-03570-6","journal-title":"J Orthop Surg Res"},{"issue":"1","key":"2390_CR14","doi-asserted-by":"publisher","first-page":"1861","DOI":"10.1080\/10717544.2021.1971798","volume":"28","author":"L Mao","year":"2021","unstructured":"Mao L, Wu W, Wang M, Guo J, Li H, Zhang S et al (2021) Targeted treatment for Osteoarthritis: drugs and delivery systems. Drug Delivery 28(1):1861\u20131876. https:\/\/doi.org\/10.1080\/10717544.2021.1971798","journal-title":"Drug Delivery"},{"key":"2390_CR15","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2023.1181619","volume":"11","author":"X Li","year":"2023","unstructured":"Li X, Han Y, Li G, Zhang Y, Wang J, Feng C (2023) Role of Wnt signaling pathway in joint development and cartilage degeneration. Front Cell Dev Biol 11:1181619. https:\/\/doi.org\/10.3389\/fcell.2023.1181619","journal-title":"Front Cell Dev Biol"},{"issue":"10","key":"2390_CR16","doi-asserted-by":"publisher","first-page":"1027","DOI":"10.1080\/1061186X.2023.2281861","volume":"31","author":"Z Iqbal","year":"2023","unstructured":"Iqbal Z, Xia J, Murtaza G, Shabbir M, Rehman K, Yujie L et al (2023) Targeting WNT signalling pathways as new therapeutic strategies for osteoarthritis. J Drug Target 31(10):1027\u20131049. https:\/\/doi.org\/10.1080\/1061186X.2023.2281861","journal-title":"J Drug Target"},{"key":"2390_CR17","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2023.109790","volume":"116","author":"W Wang","year":"2023","unstructured":"Wang W, Chu Y, Zhang P, Liang Z, Fan Z, Guo X et al (2023b) Targeting macrophage polarization as a promising therapeutic strategy for the treatment of osteoarthritis. Int Immunopharmacol 116:109790. https:\/\/doi.org\/10.1016\/j.intimp.2023.109790","journal-title":"Int Immunopharmacol"},{"key":"2390_CR18","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1016\/j.actbio.2022.10.007","volume":"154","author":"XL Xu","year":"2022","unstructured":"Xu XL, Xue Y, Ding JY, Zhu ZH, Wu XC, Song YJ et al (2022) Nanodevices for deep cartilage penetration. Acta Biomater 154:23\u201348. https:\/\/doi.org\/10.1016\/j.actbio.2022.10.007","journal-title":"Acta Biomater"},{"issue":"8","key":"2390_CR19","doi-asserted-by":"publisher","DOI":"10.3390\/nu14081607","volume":"14","author":"S Mathieu","year":"2022","unstructured":"Mathieu S, Soubrier M, Peirs C, Monfoulet LE, Boirie Y, Tournadre A (2022) A meta-analysis of the impact of nutritional supplementation on osteoarthritis symptoms. Nutrients 14(8):1607. https:\/\/doi.org\/10.3390\/nu14081607","journal-title":"Nutrients"},{"issue":"4","key":"2390_CR20","doi-asserted-by":"publisher","first-page":"589","DOI":"10.1007\/s00296-022-05244-8","volume":"43","author":"ZD Koroljevi\u0107","year":"2023","unstructured":"Koroljevi\u0107 ZD, Jordan K, Ivkovi\u0107 J, Bender DV, Peri\u0107 P (2023) Curcuma as an anti-inflammatory component in treating osteoarthritis. Rheumatol Int 43(4):589\u2013616. https:\/\/doi.org\/10.1007\/s00296-022-05244-8","journal-title":"Rheumatol Int"},{"key":"2390_CR21","doi-asserted-by":"publisher","first-page":"165","DOI":"10.2147\/DDDT.S445555","volume":"18","author":"C Yang","year":"2024","unstructured":"Yang C, Zhu Q, Chen Y, Ji K, Li S, Wu Q et al (2024) Review of the protective mechanism of curcumin on cardiovascular disease. Drug des Devel Ther 18:165\u2013192. https:\/\/doi.org\/10.2147\/DDDT.S445555","journal-title":"Drug des Devel Ther"},{"issue":"4","key":"2390_CR22","doi-asserted-by":"publisher","first-page":"693","DOI":"10.1002\/biof.2039","volume":"50","author":"T Abdul-Rahman","year":"2024","unstructured":"Abdul-Rahman T, Awuah WA, Mikhailova T, Kalmanovich J, Mehta A, Ng JC et al (2024) Antioxidant, anti-inflammatory and epigenetic potential of curcumin in Alzheimer\u2019s disease. BioFactors 50(4):693\u2013708. https:\/\/doi.org\/10.1002\/biof.2039","journal-title":"BioFactors"},{"issue":"6","key":"2390_CR23","doi-asserted-by":"publisher","DOI":"10.1042\/BSR20210817","volume":"41","author":"L Zeng","year":"2021","unstructured":"Zeng L, Yu G, Hao W, Yang K, Chen H (2021) The efficacy and safety of Curcuma longa extract and curcumin supplements on osteoarthritis: a systematic review and meta-analysis. Biosci Rep 41(6):BSR20210817. https:\/\/doi.org\/10.1042\/BSR20210817","journal-title":"Biosci Rep"},{"key":"2390_CR24","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.891822","volume":"13","author":"L Zeng","year":"2022","unstructured":"Zeng L, Yang T, Yang K, Yu G, Li J, Xiang W et al (2022) Efficacy and safety of curcumin and Curcuma longa extract in the treatment of arthritis: a systematic review and meta-analysis of randomized controlled trials. Front Immunol 13:891822. https:\/\/doi.org\/10.3389\/fimmu.2022.891822","journal-title":"Front Immunol"},{"issue":"31","key":"2390_CR25","doi-asserted-by":"publisher","first-page":"12","DOI":"10.5530\/phrev.2022.16.3","volume":"16","author":"J Neto","year":"2022","unstructured":"Neto J, Paix\u00e3o J, Vale A, David J, David J (2022) The use of Curcuma longa and its derivatives in the treatment of osteoarthritis: a scoping review. Pharmacogn Rev 16(31):12\u201321. https:\/\/doi.org\/10.5530\/phrev.2022.16.3","journal-title":"Pharmacogn Rev"},{"key":"2390_CR26","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2023.117493","volume":"321","author":"J Zhao","year":"2024","unstructured":"Zhao J, Liang G, Zhou G, Hong K, Yang W, Liu J et al (2024) Efficacy and safety of curcumin therapy for knee osteoarthritis: a Bayesian network meta-analysis. J Ethnopharmacol 321:117493. https:\/\/doi.org\/10.1016\/j.jep.2023.117493","journal-title":"J Ethnopharmacol"},{"key":"2390_CR27","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1007\/978-3-030-56153-6_16","volume-title":"Advances in experimental medicine and biology","author":"N Shokri-Mashhadi","year":"2021","unstructured":"Shokri-Mashhadi N, Bagherniya M, Askari G, Sathyapalan T, Sahebkar A (2021) A systematic review of the clinical use of curcumin for the treatment of osteoarthritis. In: Sahebkar A (ed) Advances in experimental medicine and biology, vol Vol. 1291. Springer, pp 265\u2013282. https:\/\/doi.org\/10.1007\/978-3-030-56153-6_16"},{"issue":"6","key":"2390_CR28","doi-asserted-by":"publisher","first-page":"461","DOI":"10.1177\/1941738109350438","volume":"1","author":"AJ Sophia Fox","year":"2009","unstructured":"Sophia Fox AJ, Bedi A, Rodeo SA (2009) The basic science of articular cartilage: structure, composition, and function. Sports Health 1(6):461\u2013468. https:\/\/doi.org\/10.1177\/1941738109350438","journal-title":"Sports Health"},{"issue":"4","key":"2390_CR29","doi-asserted-by":"publisher","first-page":"177","DOI":"10.3390\/jdb3040177","volume":"3","author":"H Akkiraju","year":"2015","unstructured":"Akkiraju H, Nohe A (2015) Role of chondrocytes in cartilage formation, progression of osteoarthritis and cartilage regeneration. J Dev Biol 3(4):177\u2013192. https:\/\/doi.org\/10.3390\/jdb3040177","journal-title":"J Dev Biol"},{"key":"2390_CR30","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2022.113092","volume":"151","author":"Z Jin","year":"2022","unstructured":"Jin Z, Chang B, Wei Y, Yang Y, Zhang H, Liu J et al (2022) Curcumin exerts chondroprotective effects against osteoarthritis by promoting AMPK\/PINK1\/Parkin-mediated mitophagy. Biomed Pharmacother 151:113092. https:\/\/doi.org\/10.1016\/j.biopha.2022.113092","journal-title":"Biomed Pharmacother"},{"issue":"5","key":"2390_CR31","first-page":"28","volume":"28","author":"T Yuan","year":"2022","unstructured":"Yuan T, Cai D, Hu B, Zhu Y, Qin J (2022) Therapeutic effects of curcumin on osteoarthritis and its protection of chondrocytes through the Wnt\/\u03b2-catenin signaling pathway. Altern Ther Health Med 28(5):28\u201337","journal-title":"Altern Ther Health Med"},{"issue":"9","key":"2390_CR32","doi-asserted-by":"publisher","first-page":"1434","DOI":"10.1016\/j.bcp.2007.01.005","volume":"73","author":"M Shakibaei","year":"2007","unstructured":"Shakibaei M, John T, Schulze-Tanzil G, Lehmann I, Mobasheri A (2007) Suppression of NF-\u03baB activation by curcumin leads to inhibition of expression of cyclooxygenase-2 and matrix metalloproteinase-9 in human articular chondrocytes: implications for the treatment of osteoarthritis. Biochem Pharmacol 73(9):1434\u20131445. https:\/\/doi.org\/10.1016\/j.bcp.2007.01.005","journal-title":"Biochem Pharmacol"},{"issue":"1","key":"2390_CR33","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1111\/os.12412","volume":"11","author":"JJ Zeng","year":"2019","unstructured":"Zeng JJ, Wang HD, Shen ZW, Yao XD, Wu CJ, Pan T (2019) Curcumin inhibits proliferation of synovial cells by downregulating expression of matrix metalloproteinase-3 in osteoarthritis. Orthop Surg 11(1):117\u2013125. https:\/\/doi.org\/10.1111\/os.12412","journal-title":"Orthop Surg"},{"key":"2390_CR34","doi-asserted-by":"publisher","DOI":"10.12688\/f1000research.2-147.v2","volume":"2","author":"AL Clutterbuck","year":"2013","unstructured":"Clutterbuck AL, Allaway D, Harris P, Mobasheri A (2013) Curcumin reduces prostaglandin E2, matrix metalloproteinase-3 and proteoglycan release in the secretome of interleukin-1\u03b2-treated articular cartilage. F1000Res 2:147. https:\/\/doi.org\/10.12688\/f1000research.2-147.v2","journal-title":"F1000Res"},{"issue":"2","key":"2390_CR35","first-page":"344","volume":"23","author":"KW Marshall","year":"1996","unstructured":"Marshall KW, Chan AD (1996) Bilateral canine model of osteoarthritis. J Rheumatol 23(2):344\u2013350","journal-title":"J Rheumatol"},{"key":"2390_CR36","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/8574386","author":"K Feng","year":"2019","unstructured":"Feng K, Ge Y, Chen Z, Li X, Liu Z, Li X et al (2019) Curcumin inhibits the PERK-eIF2\u03b1-CHOP pathway through promoting SIRT1 expression in oxidative stress-induced rat chondrocytes and ameliorates osteoarthritis progression in a rat model. Oxid Med Cell Longev. https:\/\/doi.org\/10.1155\/2019\/8574386","journal-title":"Oxid Med Cell Longev"},{"issue":"3","key":"2390_CR37","doi-asserted-by":"publisher","first-page":"353","DOI":"10.1002\/ddr.21509","volume":"80","author":"Y Zhang","year":"2019","unstructured":"Zhang Y, Zeng Y (2019) Curcumin reduces inflammation in knee osteoarthritis rats through blocking the TLR4\/MyD88\/NF-\u03baB signaling pathway. Drug Dev Res 80(3):353\u2013359. https:\/\/doi.org\/10.1002\/ddr.21509","journal-title":"Drug Dev Res"},{"issue":"10","key":"2390_CR38","doi-asserted-by":"publisher","first-page":"449","DOI":"10.1089\/jir.2017.0069","volume":"37","author":"Y Sun","year":"2017","unstructured":"Sun Y, Liu W, Zhang H, Li H, Liu J, Zhang F et al (2017) Curcumin prevents osteoarthritis by inhibiting the activation of inflammasome NLRP3. J Interferon Cytokine Res 37(10):449\u2013455. https:\/\/doi.org\/10.1089\/jir.2017.0069","journal-title":"J Interferon Cytokine Res"},{"issue":"6","key":"2390_CR39","doi-asserted-by":"publisher","DOI":"10.1590\/s0102-865020190060000004","volume":"34","author":"D Yan","year":"2019","unstructured":"Yan D, He B, Guo J, Li S, Wang J (2019) Involvement of TLR4 in the protective effect of intra-articular administration of curcumin on rat experimental osteoarthritis. Acta Cir Bras 34(6):e201900604. https:\/\/doi.org\/10.1590\/s0102-865020190060000004","journal-title":"Acta Cir Bras"},{"issue":"Suppl. 2","key":"2390_CR40","doi-asserted-by":"publisher","first-page":"153S","DOI":"10.1177\/19476035211043202","volume":"13","author":"A Nakahata","year":"2021","unstructured":"Nakahata A, Ito A, Nakahara R, Kishimoto A, Imaizumi A, Hashimoto T et al (2021) Intra-articular injections of curcumin monoglucuronide TBP1901 suppress articular cartilage damage and regulate subchondral bone alteration in an Osteoarthritis rat model. Cartilage 13(Suppl. 2):153S-167S. https:\/\/doi.org\/10.1177\/19476035211043202","journal-title":"Cartilage"},{"issue":"11","key":"2390_CR41","doi-asserted-by":"publisher","first-page":"940","DOI":"10.21037\/atm-21-2701","volume":"9","author":"P Wang","year":"2021","unstructured":"Wang P, Ye Y, Yuan W, Tan Y, Zhang S, Meng Q (2021) Curcumin exerts a protective effect on murine knee chondrocytes treated with IL-1\u03b2 through blocking the NF-\u03baB\/HIF-2\u03b1 signaling pathway. Ann Transl Med 9(11):940. https:\/\/doi.org\/10.21037\/atm-21-2701","journal-title":"Ann Transl Med"},{"issue":"1","key":"2390_CR42","doi-asserted-by":"publisher","first-page":"8176","DOI":"10.1038\/s41598-024-58375-2","volume":"14","author":"H Ye","year":"2024","unstructured":"Ye H, Long Y, Yang JM, Wu YL, Dong LY, Zhong YB et al (2024) Curcumin regulates autophagy through the SIRT3-SOD2-SASP signaling pathway to improve quadriceps femoris muscle atrophy in a knee Osteoarthritis rat model. Sci Rep 14(1):8176. https:\/\/doi.org\/10.1038\/s41598-024-58375-2","journal-title":"Sci Rep"},{"key":"2390_CR43","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2023.115309","volume":"166","author":"MM Saber","year":"2023","unstructured":"Saber MM, Mahmoud MM, Amin HM, Essam RM (2023) Therapeutic effects of combining curcumin and swimming in Osteoarthritis using a rat model. Biomed Pharmacother 166:115309. https:\/\/doi.org\/10.1016\/j.biopha.2023.115309","journal-title":"Biomed Pharmacother"},{"issue":"1","key":"2390_CR44","doi-asserted-by":"publisher","DOI":"10.1186\/s13075-016-1025-y","volume":"18","author":"Z Zhang","year":"2016","unstructured":"Zhang Z, Leong DJ, Xu L, He Z, Wang A, Navati M et al (2016) Curcumin slows osteoarthritis progression and relieves osteoarthritis-associated pain symptoms in a post-traumatic osteoarthritis mouse model. Arthritis Res Ther 18(1):128. https:\/\/doi.org\/10.1186\/s13075-016-1025-y","journal-title":"Arthritis Res Ther"},{"issue":"2","key":"2390_CR45","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1007\/s10068-019-00679-5","volume":"29","author":"HJ Park","year":"2020","unstructured":"Park HJ, Lee CK, Song SH, Yun JH, Lee A, Park HJ (2020) Highly bioavailable curcumin powder suppresses articular cartilage damage in rats with mono-iodoacetate-induced Osteoarthritis. Food Sci Biotechnol 29(2):251\u2013263. https:\/\/doi.org\/10.1007\/s10068-019-00679-5","journal-title":"Food Sci Biotechnol"},{"issue":"3","key":"2390_CR46","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0230228","volume":"15","author":"T Nicoliche","year":"2020","unstructured":"Nicoliche T, Maldonado DC, Faber J, Silva M (2020) Evaluation of the articular cartilage in the knees of rats with induced arthritis treated with curcumin. PLoS ONE 15(3):e0230228. https:\/\/doi.org\/10.1371\/journal.pone.0230228","journal-title":"PLoS ONE"},{"issue":"11","key":"2390_CR47","doi-asserted-by":"publisher","first-page":"727","DOI":"10.1590\/S0102-86502014001800006","volume":"29","author":"N Nonose","year":"2014","unstructured":"Nonose N, Pereira JA, Machado PR, Rodrigues MR, Sato DT, Martinez CA (2014) Oral administration of curcumin (Curcuma longa) can attenuate the neutrophil inflammatory response in zymosan-induced arthritis in rats. Acta Cir Bras 29(11):727\u2013734. https:\/\/doi.org\/10.1590\/S0102-86502014001800006","journal-title":"Acta Cir Bras"},{"issue":"11","key":"2390_CR48","doi-asserted-by":"publisher","first-page":"1625","DOI":"10.1002\/ptr.5174","volume":"28","author":"Y Panahi","year":"2014","unstructured":"Panahi Y, Rahimnia AR, Sharafi M, Alishiri G, Saburi A, Sahebkar A (2014) Curcuminoid treatment for knee osteoarthritis: a randomized double-blind placebo-controlled trial. Phytother Res 28(11):1625\u20131631. https:\/\/doi.org\/10.1002\/ptr.5174","journal-title":"Phytother Res"},{"issue":"6","key":"2390_CR49","doi-asserted-by":"publisher","first-page":"933","DOI":"10.1007\/s00776-014-0633-0","volume":"19","author":"Y Nakagawa","year":"2014","unstructured":"Nakagawa Y, Mukai S, Yamada S, Matsuoka M, Tarumi E, Hashimoto T et al (2014) Short-term effects of highly bioavailable curcumin for treating knee osteoarthritis: a randomized, double-blind, placebo-controlled prospective study. J Orthop Sci 19(6):933\u2013939. https:\/\/doi.org\/10.1007\/s00776-014-0633-0","journal-title":"J Orthop Sci"},{"issue":"1","key":"2390_CR50","doi-asserted-by":"publisher","first-page":"214","DOI":"10.1186\/s13063-019-3327-2","volume":"20","author":"D Shep","year":"2019","unstructured":"Shep D, Khanwelkar C, Gade P, Karad S (2019) Safety and efficacy of curcumin versus diclofenac in knee osteoarthritis: a randomized open-label parallel-arm study. Trials 20(1):214. https:\/\/doi.org\/10.1186\/s13063-019-3327-2","journal-title":"Trials"},{"issue":"2","key":"2390_CR51","doi-asserted-by":"publisher","first-page":"158","DOI":"10.2174\/1874471013666191223152658","volume":"16","author":"K Hashemzadeh","year":"2020","unstructured":"Hashemzadeh K, Davoudian N, Jaafari MR, Mirfeizi Z (2020) The effect of nanocurcumin in improvement of knee osteoarthritis: a randomized clinical trial. Curr Rheumatol Rev 16(2):158\u2013164. https:\/\/doi.org\/10.2174\/1874471013666191223152658","journal-title":"Curr Rheumatol Rev"},{"issue":"4","key":"2390_CR52","doi-asserted-by":"publisher","first-page":"436","DOI":"10.1089\/jmf.2020.0074","volume":"24","author":"L Calder\u00f3n-P\u00e9rez","year":"2021","unstructured":"Calder\u00f3n-P\u00e9rez L, Llaurad\u00f3 E, Companys J, Pla-Pag\u00e0 L, Boqu\u00e9 N, Puiggr\u00f3s F et al (2021) Acute effects of turmeric extracts on knee joint pain: a pilot randomized controlled trial. J Med Food 24(4):436\u2013440. https:\/\/doi.org\/10.1089\/jmf.2020.0074","journal-title":"J Med Food"},{"issue":"2","key":"2390_CR53","doi-asserted-by":"publisher","first-page":"209","DOI":"10.3109\/19390211.2015.1008611","volume":"13","author":"Y Panahi","year":"2016","unstructured":"Panahi Y, Alishiri GH, Parvin S, Sahebkar A (2016) Mitigation of systemic oxidative stress by curcuminoids in osteoarthritis: results of a randomized controlled trial. J Diet Suppl 13(2):209\u2013220. https:\/\/doi.org\/10.3109\/19390211.2015.1008611","journal-title":"J Diet Suppl"},{"issue":"10","key":"2390_CR54","doi-asserted-by":"publisher","first-page":"521","DOI":"10.1055\/s-0034-1384536","volume":"65","author":"AR Rahimnia","year":"2015","unstructured":"Rahimnia AR, Panahi Y, Alishiri G, Sharafi M, Sahebkar A (2015) Impact of supplementation with curcuminoids on systemic inflammation in patients with knee osteoarthritis: findings from a randomized double-blind placebo-controlled trial. Drug Res (Stuttg) 65(10):521\u2013525. https:\/\/doi.org\/10.1055\/s-0034-1384536","journal-title":"Drug Res (Stuttg)"},{"issue":"1","key":"2390_CR55","doi-asserted-by":"publisher","DOI":"10.1186\/s13075-019-1960-5","volume":"21","author":"Y Henrotin","year":"2019","unstructured":"Henrotin Y, Malaise M, Wittoek R, de Vlam K, Brasseur JP, Luyten FP et al (2019) Bio-optimized Curcuma longa extract is efficient on knee osteoarthritis pain: a double-blind multicenter randomized placebo-controlled three-arm study. Arthritis Res Ther 21(1):179. https:\/\/doi.org\/10.1186\/s13075-019-1960-5","journal-title":"Arthritis Res Ther"},{"issue":"3","key":"2390_CR56","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1016\/j.joca.2011.12.003","volume":"20","author":"PM van der Kraan","year":"2012","unstructured":"van der Kraan PM, van den Berg WB (2012) Chondrocyte hypertrophy and osteoarthritis: role in initiation and progression of cartilage degeneration? Osteoarthritis Cartilage 20(3):223\u2013232. https:\/\/doi.org\/10.1016\/j.joca.2011.12.003","journal-title":"Osteoarthritis Cartilage"},{"issue":"4","key":"2390_CR57","doi-asserted-by":"publisher","first-page":"3662","DOI":"10.3390\/ijms24043662","volume":"24","author":"L Petrigna","year":"2023","unstructured":"Petrigna L, Trovato B, Roggio F, Castorina A, Musumeci G (2023) Molecular assessment of healthy and pathological articular cartilages in physically active people: a scoping review. Int J Mol Sci 24(4):3662. https:\/\/doi.org\/10.3390\/ijms24043662","journal-title":"Int J Mol Sci"},{"issue":"12","key":"2390_CR58","doi-asserted-by":"publisher","first-page":"1575","DOI":"10.1016\/j.joca.2022.09.003","volume":"30","author":"S Han","year":"2022","unstructured":"Han S (2022) Osteoarthritis year in review 2022: biology. Osteoarthritis Cartilage 30(12):1575\u20131582. https:\/\/doi.org\/10.1016\/j.joca.2022.09.003","journal-title":"Osteoarthritis Cartilage"},{"issue":"1","key":"2390_CR59","doi-asserted-by":"publisher","DOI":"10.1186\/s13075-022-02859-x","volume":"24","author":"Y Liu","year":"2022","unstructured":"Liu Y, Zhang Z, Li T, Xu H, Zhang H (2022) Senescence in osteoarthritis: from mechanism to potential treatment. Arthritis Res Ther 24(1):174. https:\/\/doi.org\/10.1186\/s13075-022-02859-x","journal-title":"Arthritis Res Ther"},{"key":"2390_CR60","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2020.101249","volume":"66","author":"L Zheng","year":"2021","unstructured":"Zheng L, Zhang Z, Sheng P, Mobasheri A (2021) The role of metabolism in chondrocyte dysfunction and the progression of osteoarthritis. Ageing Res Rev 66:101249. https:\/\/doi.org\/10.1016\/j.arr.2020.101249","journal-title":"Ageing Res Rev"},{"key":"2390_CR61","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2022.114118","volume":"158","author":"J Liu","year":"2023","unstructured":"Liu J, Jia S, Yang Y, Piao L, Wang Z, Jin Z et al (2023) Exercise-induced meteorin-like protects chondrocytes against inflammation and pyroptosis in osteoarthritis by inhibiting PI3K\/Akt\/NF-\u03baB and NLRP3\/caspase-1\/GSDMD signaling. Biomed Pharmacother 158:114118. https:\/\/doi.org\/10.1016\/j.biopha.2022.114118","journal-title":"Biomed Pharmacother"},{"key":"2390_CR62","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2023.115707","volume":"215","author":"R Zhu","year":"2023","unstructured":"Zhu R, Wang Y, Ouyang Z, Hao W, Zhou F, Lin Y et al (2023) Targeting regulated chondrocyte death in osteoarthritis therapy. Biochem Pharmacol 215:115707. https:\/\/doi.org\/10.1016\/j.bcp.2023.115707","journal-title":"Biochem Pharmacol"},{"issue":"3","key":"2390_CR63","doi-asserted-by":"publisher","first-page":"395","DOI":"10.1007\/s12192-020-01079-z","volume":"25","author":"C Jiang","year":"2020","unstructured":"Jiang C, Luo P, Li X, Liu P, Li Y, Xu J (2020) Nrf2\/ARE is a key pathway for curcumin-mediated protection of temporomandibular joint chondrocytes from oxidative stress and inflammation. Cell Stress Chaperones 25(3):395\u2013406. https:\/\/doi.org\/10.1007\/s12192-020-01079-z","journal-title":"Cell Stress Chaperones"},{"issue":"5","key":"2390_CR64","doi-asserted-by":"publisher","first-page":"976","DOI":"10.1002\/cbin.11541","volume":"45","author":"T Chen","year":"2021","unstructured":"Chen T, Zhou R, Chen Y, Fu W, Wei X, Ma G et al (2021) Curcumin ameliorates IL-1\u03b2-induced apoptosis by activating autophagy and inhibiting the NF-\u03baB signaling pathway in rat primary articular chondrocytes. Cell Biol Int 45(5):976\u2013988. https:\/\/doi.org\/10.1002\/cbin.11541","journal-title":"Cell Biol Int"},{"issue":"14","key":"2390_CR65","doi-asserted-by":"publisher","first-page":"7645","DOI":"10.3390\/ijms22147645","volume":"22","author":"C Buhrmann","year":"2021","unstructured":"Buhrmann C, Brockmueller A, Mueller AL, Shayan P, Shakibaei M (2021) Curcumin attenuates environment-derived osteoarthritis by Sox9\/NF-\u03baB signaling axis. Int J Mol Sci 22(14):7645. https:\/\/doi.org\/10.3390\/ijms22147645","journal-title":"Int J Mol Sci"},{"issue":"4","key":"2390_CR66","doi-asserted-by":"publisher","first-page":"414","DOI":"10.3390\/nu9040414","volume":"9","author":"X Li","year":"2017","unstructured":"Li X, Feng K, Li J, Yu D, Fan Q, Tang T et al (2017) Curcumin inhibits apoptosis of chondrocytes through activation of ERK1\/2 signaling pathways and induction of autophagy. Nutrients 9(4):414. https:\/\/doi.org\/10.3390\/nu9040414","journal-title":"Nutrients"},{"key":"2390_CR67","doi-asserted-by":"publisher","DOI":"10.3389\/fbioe.2022.994816","volume":"10","author":"Q Sun","year":"2022","unstructured":"Sun Q, Yin W, Ru X, Liu C, Song B, Qian Z (2022) Dual role of injectable curcumin-loaded microgels for efficient repair of osteoarthritic cartilage injury. Front Bioeng Biotechnol 10:994816. https:\/\/doi.org\/10.3389\/fbioe.2022.994816","journal-title":"Front Bioeng Biotechnol"},{"key":"2390_CR68","doi-asserted-by":"publisher","DOI":"10.1177\/0963689721993776","volume":"30","author":"R Zhang","year":"2021","unstructured":"Zhang R, Zhang Q, Zou Z, Li Z, Jin M, An J et al (2021) Curcumin supplementation enhances bone marrow mesenchymal stem cells to promote the anabolism of articular chondrocytes and cartilage repair. Cell Transplant 30:0963689721993776. https:\/\/doi.org\/10.1177\/0963689721993776","journal-title":"Cell Transplant"},{"issue":"2","key":"2390_CR69","doi-asserted-by":"publisher","first-page":"643","DOI":"10.1016\/j.arthro.2021.08.032","volume":"38","author":"J Hernigou","year":"2022","unstructured":"Hernigou J, Verdonk P, Homma Y, Verdonk R, Goodman SB, Hernigou P (2022) Nonoperative and operative bone and cartilage regeneration and orthopaedic biologics of the hip: an orthoregeneration network foundation hip review. Arthrosc J Arthroscop Related Surg 38(2):643\u2013656. https:\/\/doi.org\/10.1016\/j.arthro.2021.08.032","journal-title":"Arthrosc J Arthroscop Related Surg"},{"issue":"20","key":"2390_CR70","doi-asserted-by":"publisher","first-page":"9680","DOI":"10.26355\/eurrev_202310_34139","volume":"27","author":"HY Wu","year":"2023","unstructured":"Wu HY, Yu HT, Kang B, Xuan YY, Zhang HQ, Li XS (2023) Curcumin nanoparticles and the therapeutic potential of curcumin for musculoskeletal disorders. Eur Rev Med Pharmacol Sci 27(20):9680\u20139702. https:\/\/doi.org\/10.26355\/eurrev_202310_34139","journal-title":"Eur Rev Med Pharmacol Sci"},{"issue":"1","key":"2390_CR71","doi-asserted-by":"publisher","first-page":"578","DOI":"10.1196\/annals.1329.067","volume":"1030","author":"G Schulze-Tanzil","year":"2004","unstructured":"Schulze-Tanzil G, Mobasheri A, Sendzik J, John T, Shakibaei M (2004) Effects of curcumin (diferuloylmethane) on nuclear factor kappaB signaling in interleukin-1\u03b2-stimulated chondrocytes. Ann N Y Acad Sci 1030(1):578\u2013586. https:\/\/doi.org\/10.1196\/annals.1329.067","journal-title":"Ann N Y Acad Sci"},{"issue":"5\u20136","key":"2390_CR72","doi-asserted-by":"publisher","first-page":"487","DOI":"10.1016\/j.aanat.2005.06.007","volume":"187","author":"M Shakibaei","year":"2005","unstructured":"Shakibaei M, Schulze-Tanzil G, John T, Mobasheri A (2005) Curcumin protects human chondrocytes from IL-1\u03b2-induced inhibition of collagen type II and \u03b21-integrin expression and activation of caspase-3: an immunomorphological study. Ann Anat 187(5\u20136):487\u2013497. https:\/\/doi.org\/10.1016\/j.aanat.2005.06.007","journal-title":"Ann Anat"},{"issue":"4","key":"2390_CR73","doi-asserted-by":"publisher","first-page":"168","DOI":"10.1007\/s00011-006-0067-z","volume":"55","author":"JK Jackson","year":"2006","unstructured":"Jackson JK, Higo T, Hunter WL, Burt HM (2006) The antioxidants curcumin and quercetin inhibit inflammatory processes associated with arthritis. Inflamm Res 55(4):168\u2013175. https:\/\/doi.org\/10.1007\/s00011-006-0067-z","journal-title":"Inflamm Res"},{"issue":"2","key":"2390_CR74","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1093\/rheumatology\/kei132","volume":"45","author":"S Lev-Ari","year":"2006","unstructured":"Lev-Ari S, Strier L, Kazanov D, Elkayam O, Lichtenberg D, Caspi D et al (2006) Curcumin synergistically potentiates the growth-inhibitory and pro-apoptotic effects of celecoxib in osteoarthritis synovial adherent cells. Rheumatology (Oxford) 45(2):171\u2013177. https:\/\/doi.org\/10.1093\/rheumatology\/kei132","journal-title":"Rheumatology (Oxford)"},{"issue":"10","key":"2390_CR75","doi-asserted-by":"publisher","first-page":"1205","DOI":"10.1016\/j.joca.2008.01.013","volume":"16","author":"S Toegel","year":"2008","unstructured":"Toegel S, Wu SQ, Piana C, Unger FM, Wirth M, Goldring MB et al (2008) Comparison between chondroprotective effects of glucosamine, curcumin, and diacerein in IL-1\u03b2-stimulated C-28\/I2 chondrocytes. Osteoarthritis Cartilage 16(10):1205\u20131212. https:\/\/doi.org\/10.1016\/j.joca.2008.01.013","journal-title":"Osteoarthritis Cartilage"},{"issue":"1","key":"2390_CR76","doi-asserted-by":"publisher","first-page":"428","DOI":"10.1111\/j.1749-6632.2009.04687.x","volume":"1171","author":"AL Clutterbuck","year":"2009","unstructured":"Clutterbuck AL, Mobasheri A, Shakibaei M, Allaway D, Harris P (2009) Interleukin-1\u03b2-induced extracellular matrix degradation and glycosaminoglycan release is inhibited by curcumin in an explant model of cartilage inflammation. Ann N Y Acad Sci 1171(1):428\u2013435. https:\/\/doi.org\/10.1111\/j.1749-6632.2009.04687.x","journal-title":"Ann N Y Acad Sci"},{"issue":"12","key":"2390_CR77","doi-asserted-by":"publisher","first-page":"899","DOI":"10.1007\/s00011-009-0063-1","volume":"58","author":"M Mathy-Hartert","year":"2009","unstructured":"Mathy-Hartert M, Jacquemond-Collet I, Priem F, Sanchez C, Lambert C, Henrotin Y (2009) Curcumin inhibits pro-inflammatory mediators and metalloproteinase-3 production by chondrocytes. Inflamm Res 58(12):899\u2013908. https:\/\/doi.org\/10.1007\/s00011-009-0063-1","journal-title":"Inflamm Res"},{"issue":"4","key":"2390_CR78","doi-asserted-by":"publisher","DOI":"10.1186\/ar3065","volume":"12","author":"C Buhrmann","year":"2010","unstructured":"Buhrmann C, Mobasheri A, Matis U, Shakibaei M (2010) Curcumin-mediated suppression of nuclear factor-\u03baB promotes chondrogenic differentiation of mesenchymal stem cells in a high-density co-culture microenvironment. Arthritis Res Ther 12(4):R127. https:\/\/doi.org\/10.1186\/ar3065","journal-title":"Arthritis Res Ther"},{"issue":"1\u20132","key":"2390_CR79","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1159\/000345345","volume":"91","author":"Q Yang","year":"2013","unstructured":"Yang Q, Wu S, Mao X, Wang W, Tai H (2013) Inhibition effect of curcumin on TNF-\u03b1 and MMP-13 expression induced by advanced glycation end products in chondrocytes. Pharmacology 91(1\u20132):77\u201385. https:\/\/doi.org\/10.1159\/000345345","journal-title":"Pharmacology"},{"issue":"2","key":"2390_CR80","doi-asserted-by":"publisher","first-page":"1837","DOI":"10.3892\/mmr.2017.6771","volume":"16","author":"J Wang","year":"2017","unstructured":"Wang J, Ma J, Gu JH, Wang FY, Shang XS, Tao HR et al (2017) Regulation of type II collagen, matrix metalloproteinase-13, and cell proliferation by interleukin-1\u03b2 is mediated by curcumin via inhibition of NF-\u03baB signaling in rat chondrocytes. Mol Med Rep 16(2):1837\u20131845. https:\/\/doi.org\/10.3892\/mmr.2017.6771","journal-title":"Mol Med Rep"},{"issue":"8","key":"2390_CR81","doi-asserted-by":"publisher","first-page":"762","DOI":"10.1248\/cpb.c17-00225","volume":"65","author":"Z Cao","year":"2017","unstructured":"Cao Z, Dou C, Dong S (2017) Curcumin inhibits chondrocyte hypertrophy of mesenchymal stem cells through Indian hedgehog and Notch signaling pathways. Chem Pharm Bull 65(8):762\u2013767. https:\/\/doi.org\/10.1248\/cpb.c17-00225","journal-title":"Chem Pharm Bull"},{"key":"2390_CR82","doi-asserted-by":"publisher","first-page":"146","DOI":"10.1016\/j.ejphar.2018.03.038","volume":"828","author":"P Zhao","year":"2018","unstructured":"Zhao P, Cheng J, Geng J, Yang M, Zhang Y, Zhang Q et al (2018) Curcumin protects rabbit articular chondrocytes against sodium nitroprusside-induced apoptosis in vitro. Eur J Pharmacol 828:146\u2013153. https:\/\/doi.org\/10.1016\/j.ejphar.2018.03.038","journal-title":"Eur J Pharmacol"},{"issue":"18","key":"2390_CR83","doi-asserted-by":"publisher","first-page":"10855","DOI":"10.1111\/jcmm.15714","volume":"24","author":"B Qiu","year":"2020","unstructured":"Qiu B, Xu X, Yi P, Hao Y (2020) Curcumin reinforces mesenchymal stem cell-derived exosomes in attenuating osteoarthritis via modulation of the miR-124\/NF-\u03baB and miR-143\/ROCK1\/TLR9 signaling pathways. J Cell Mol Med 24(18):10855\u201310865. https:\/\/doi.org\/10.1111\/jcmm.15714","journal-title":"J Cell Mol Med"},{"issue":"10","key":"2390_CR84","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2023.e20163","volume":"9","author":"Y Zhou","year":"2023","unstructured":"Zhou Y, Jia Z, Wang J, Huang S, Yang S, Xiao S et al (2023) Curcumin reverses erastin-induced chondrocyte ferroptosis by upregulating Nrf2. Heliyon 9(10):e20163. https:\/\/doi.org\/10.1016\/j.heliyon.2023.e20163","journal-title":"Heliyon"},{"issue":"5","key":"2390_CR85","doi-asserted-by":"publisher","first-page":"3313","DOI":"10.1007\/s00210-023-02785-y","volume":"397","author":"W Deng","year":"2024","unstructured":"Deng W, He Q, Zhang W (2024b) Analysis of the mechanism of curcumin against osteoarthritis using metabolomics and transcriptomics. Naunyn Schmiedebergs Arch Pharmacol 397(5):3313\u20133329. https:\/\/doi.org\/10.1007\/s00210-023-02785-y","journal-title":"Naunyn Schmiedebergs Arch Pharmacol"},{"key":"2390_CR86","doi-asserted-by":"publisher","first-page":"5039","DOI":"10.2147\/JIR.S459867","volume":"17","author":"X Wang","year":"2024","unstructured":"Wang X, Yu H, Zhang Y, Chang X, Liu C, Wen X et al (2024) Curcumin alleviates osteoarthritis through the p38 MAPK pathway: network pharmacological prediction and experimental confirmation. J Inflamm Res 17:5039\u20135056. https:\/\/doi.org\/10.2147\/JIR.S459867","journal-title":"J Inflamm Res"},{"key":"2390_CR87","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2020.106607","volume":"85","author":"M Atabaki","year":"2020","unstructured":"Atabaki M, Shariati-Sarabi Z, Tavakkol-Afshari J, Mohammadi M (2020) Significant immunomodulatory properties of curcumin in patients with osteoarthritis: a successful clinical trial in Iran. Int Immunopharmacol 85:106607. https:\/\/doi.org\/10.1016\/j.intimp.2020.106607","journal-title":"Int Immunopharmacol"},{"issue":"1","key":"2390_CR88","doi-asserted-by":"publisher","first-page":"305","DOI":"10.1186\/s12906-020-03105-0","volume":"20","author":"N Jamali","year":"2020","unstructured":"Jamali N, Adib-Hajbaghery M, Soleimani A (2020) The effect of curcumin ointment on knee pain in older adults with osteoarthritis: a randomized placebo trial. BMC Complement Med Ther 20(1):305. https:\/\/doi.org\/10.1186\/s12906-020-03105-0","journal-title":"BMC Complement Med Ther"},{"key":"2390_CR89","doi-asserted-by":"publisher","first-page":"117954412094847","DOI":"10.1177\/1179544120948471","volume":"13","author":"Y Nakagawa","year":"2020","unstructured":"Nakagawa Y, Mukai S, Yamada S, Murata S, Yabumoto H, Maeda T et al (2020) The efficacy and safety of highly bioavailable curcumin for treating knee osteoarthritis: a 6-month open-label prospective study. Clin Med Insights Arthritis Musculoskeletal Disorders 13:1179544120948471. https:\/\/doi.org\/10.1177\/1179544120948471","journal-title":"Clin Med Insights Arthritis Musculoskeletal Disorders"},{"key":"2390_CR90","doi-asserted-by":"publisher","DOI":"10.36948\/ijfmr.2026.v08i02.76380","author":"CN Raparthi","year":"2026","unstructured":"Raparthi CN (2026) Treatment of osteoarthritis using curcumin: a comprehensive review of evidence up to 2025. Int J Multidiscip Res. https:\/\/doi.org\/10.36948\/ijfmr.2026.v08i02.76380","journal-title":"Int J Multidiscip Res"},{"issue":"1","key":"2390_CR91","doi-asserted-by":"publisher","first-page":"156","DOI":"10.1177\/2156587216636747","volume":"22","author":"K Perkins","year":"2017","unstructured":"Perkins K, Sahy W, Beckett RD (2017) Efficacy of curcuma for treatment of osteoarthritis. J Evid Based Complement Altern Med 22(1):156\u2013165. https:\/\/doi.org\/10.1177\/2156587216636747","journal-title":"J Evid Based Complement Altern Med"}],"container-title":["Inflammopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10787-026-02390-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10787-026-02390-4","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10787-026-02390-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T23:55:19Z","timestamp":1792194919000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10787-026-02390-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,2]]},"references-count":91,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2026,10]]}},"alternative-id":["2390"],"URL":"https:\/\/doi.org\/10.1007\/s10787-026-02390-4","relation":{},"ISSN":["0925-4692","1568-5608"],"issn-type":[{"value":"0925-4692","type":"print"},{"value":"1568-5608","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,2]]},"assertion":[{"value":"10 July 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 August 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 September 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}