{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T08:57:02Z","timestamp":1790585822227,"version":"4.1.0"},"reference-count":70,"publisher":"Springer Science and Business Media LLC","license":[{"start":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T00:00:00Z","timestamp":1790467200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T00:00:00Z","timestamp":1790467200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Inflammopharmacol"],"DOI":"10.1007\/s10787-026-02404-1","type":"journal-article","created":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T04:46:10Z","timestamp":1790484370000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Elucidating the anti-arthritic potential of Crinum asiaticum L. through the TNF signalling pathway: an integrated computational pharmacology, in-vitro and in-vivo approach"],"prefix":"10.1007","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6840-084X","authenticated-orcid":false,"given":"Diptirani","family":"Rath","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Subhasish","family":"Sahoo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Om Archita","family":"Panda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandesh Kumar","family":"Pattanaik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Swarna Prava","family":"Lenka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,9,27]]},"reference":[{"issue":"2","key":"2404_CR1","doi-asserted-by":"publisher","first-page":"1422","DOI":"10.3390\/cimb45020093","volume":"45","author":"A Alghamdi","year":"2023","unstructured":"Alghamdi A, Abouzied AS, Alamri A, Anwar S, Ansari M, Khadra I, Zaki YH, Gomha SM (2023) Synthesis, molecular docking, and dynamic simulation targeting main protease (Mpro) of new, thiazole clubbed pyridine scaffolds as potential COVID-19 inhibitors. Curr Issues Mol Biol 45(2):1422\u20131442. https:\/\/doi.org\/10.3390\/cimb45020093","journal-title":"Curr Issues Mol Biol"},{"key":"2404_CR2","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines13020454","author":"P Ansari","year":"2025","unstructured":"Ansari P, Reberio AD, Ansari NJ, Kumar S, Khan JT, Chowdhury S, Abd El-Mordy FM, Hannan JMA, Flatt PR, Abdel-Wahab YHA, Seidel V (2025) Therapeutic potential of medicinal plants and their phytoconstituents in diabetes, cancer, infections, cardiovascular diseases, inflammation and gastrointestinal disorders. Biomedicines. https:\/\/doi.org\/10.3390\/biomedicines13020454","journal-title":"Biomedicines"},{"key":"2404_CR3","doi-asserted-by":"publisher","unstructured":"Bazzi-Allahri F, Shiri F, Ahmadi S, Toropova, AP, and Toropov AA (2024) SMILES-based QSAR virtual screening to identify potential therapeutics for COVID-19 by targeting 3CLpro and RdRp viral proteins. BMC Chem, 18(1). https:\/\/doi.org\/10.1186\/s13065-024-01302-3","DOI":"10.1186\/s13065-024-01302-3"},{"key":"2404_CR4","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2022.113126","author":"R Ben Mrid","year":"2022","unstructured":"Ben Mrid R, Bouchmaa N, Ainani H, El Fatimy R, Malka G, Mazini L (2022) Anti-rheumatoid drugs advancements: new insights into the molecular treatment of rheumatoid arthritis. Biomed Pharmacother. https:\/\/doi.org\/10.1016\/j.biopha.2022.113126","journal-title":"Biomed Pharmacother"},{"key":"2404_CR5","doi-asserted-by":"publisher","DOI":"10.3892\/wasj.2025.345","author":"A Bhakta","year":"2025","unstructured":"Bhakta A, Gambhir L, Verma R (2025) Pathogenesis and treatment of rheumatoid arthritis with focus on herbal therapeutic approaches (Review). World Acad Sci J. https:\/\/doi.org\/10.3892\/wasj.2025.345","journal-title":"World Acad Sci J"},{"issue":"9","key":"2404_CR6","doi-asserted-by":"publisher","first-page":"368","DOI":"10.1007\/s00011-006-6026-x","volume":"55","author":"X Cai","year":"2006","unstructured":"Cai X, Wong YF, Zhou H, Liu Q, Xie Y, Jiang ZH, Bian ZX, Xu HX, Liu L (2006) Manipulation of the induction of adjuvant arthritis in Sprague-Dawley rats. Inflamm Res 55(9):368\u2013377. https:\/\/doi.org\/10.1007\/s00011-006-6026-x","journal-title":"Inflamm Res"},{"key":"2404_CR7","doi-asserted-by":"publisher","DOI":"10.1016\/j.phytochem.2025.114383","author":"W Chaichompoo","year":"2025","unstructured":"Chaichompoo W, Rojsitthisak P, Supaweera N, Poldorn P, Pabuprapap W, Chunglok W, Wongnongwa Y, Suksamrarn A (2025) Amaryllidaceae alkaloids with nitric oxide inhibitory activity from the leaves of Crinum asiaticum L. var. asiaticum. Phytochemistry. https:\/\/doi.org\/10.1016\/j.phytochem.2025.114383","journal-title":"Phytochemistry"},{"key":"2404_CR8","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2025.1615519","author":"Y Chen","year":"2025","unstructured":"Chen Y, Deng Y, Zheng H, Li B, Yang Y, Huang J, Yuan H, Wang M, Wang W, Yu H (2025) Xuetongsu attenuates synovial inflammation in rheumatoid arthritis by inhibiting the IL-23\/IL-17\/NF-\u03baB inflammatory axis. Front Pharmacol. https:\/\/doi.org\/10.3389\/fphar.2025.1615519","journal-title":"Front Pharmacol"},{"key":"2404_CR9","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/474616","author":"M Choudhary","year":"2014","unstructured":"Choudhary M, Kumar V, Gupta P, Singh S (2014) Investigation of antiarthritic potential of Plumeria alba L. leaves in acute and chronic models of arthritis. BioMed Res Int. https:\/\/doi.org\/10.1155\/2014\/474616","journal-title":"BioMed Res Int"},{"key":"2404_CR10","doi-asserted-by":"publisher","DOI":"10.1038\/srep42717","author":"A Daina","year":"2017","unstructured":"Daina A, Michielin O, Zoete V (2017) SwissADME: a free web tool to evaluate pharmacokinetics, drug-likeness and medicinal chemistry friendliness of small molecules. Sci Rep. https:\/\/doi.org\/10.1038\/srep42717","journal-title":"Sci Rep"},{"issue":"47","key":"2404_CR11","doi-asserted-by":"publisher","first-page":"44955","DOI":"10.1021\/acsomega.3c06374","volume":"8","author":"E Dar","year":"2023","unstructured":"Dar E, Mobashar A, Shabbir A, Mushtaq MN, Anjum I, Gaafar ARZ, Nafidi HA, Bourhia M (2023) Mechanistic evaluation of antiarthritic effects of Citronellol in CFA-induced arthritic rats. ACS Omega 8(47):44955\u201344963. https:\/\/doi.org\/10.1021\/acsomega.3c06374","journal-title":"ACS Omega"},{"key":"2404_CR12","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2024.118944","volume":"337","author":"C Das","year":"2025","unstructured":"Das C, Kar P, Dash P, Pradhan D, Rai VK, Rajwar TK, Halder J, Babu S, Sardar KK, Raha A, Das D, Manoharadas S, Kar B, Ghosh G, Rath G (2025) Protective effect of Tecoma stans (L.) Juss.ex Kunth in CFA-induced arthritic rats. J Ethnopharmacol 337:118944. https:\/\/doi.org\/10.1016\/j.jep.2024.118944","journal-title":"J Ethnopharmacol"},{"key":"2404_CR13","doi-asserted-by":"publisher","unstructured":"Farrugia M, and Baron B (2016a) The role of TNF-\u03b1 in rheumatoid arthritis: a focus on regulatory T cells. J Clin Trans Res, 2(3). https:\/\/doi.org\/10.18053\/jctres.02.201603.005","DOI":"10.18053\/jctres.02.201603.005"},{"key":"2404_CR14","doi-asserted-by":"publisher","unstructured":"Farrugia M, and Baron B (2016b) The role of TNF-\u03b1 in rheumatoid arthritis: a focus on regulatory T cells. J Clin Trans Res, 2(3). https:\/\/doi.org\/10.18053\/jctres.02.201603.005","DOI":"10.18053\/jctres.02.201603.005"},{"key":"2404_CR15","doi-asserted-by":"publisher","DOI":"10.3390\/ph17081019","author":"E Fikry","year":"2024","unstructured":"Fikry E, Orfali R, Tawfeek N, Perveen S, Ghafar S, El-Domiaty MM, El-Shafae AM (2024) Unveiling the bioactive efficacy of Cupressus sempervirens \u2018Stricta\u2019 essential oil: composition, in vitro activities, and in silico analyses. Pharmaceuticals (Basel). https:\/\/doi.org\/10.3390\/ph17081019","journal-title":"Pharmaceuticals (Basel)"},{"key":"2404_CR16","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1016\/j.ijbiomac.2022.10.117","volume":"224","author":"S Gorantla","year":"2023","unstructured":"Gorantla S, Puppala ER, Naidu VGM, Saha RN, Singhvi G (2023) Hyaluronic acid-coated proglycosomes for topical delivery of tofacitinib in rheumatoid arthritis condition: formulation design, in vitro, ex vivo characterization, and in vivo efficacy studies. Int J Biol Macromol 224:207\u2013222. https:\/\/doi.org\/10.1016\/j.ijbiomac.2022.10.117","journal-title":"Int J Biol Macromol"},{"key":"2404_CR17","doi-asserted-by":"publisher","DOI":"10.1007\/s44466-025-00022-0","author":"Z He","year":"2026","unstructured":"He Z, Hao H, Chen B, Li X, Mao D, Jin Y, Zhao K, Chen G (2026) Pathogenesis and therapeutic strategies of osteoarthritis: roles of immune cells, inflammatory mediators, and pathogenic signaling pathways. Immun Inflamm. https:\/\/doi.org\/10.1007\/s44466-025-00022-0","journal-title":"Immun Inflamm"},{"key":"2404_CR18","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2025.120321","author":"HS Heo","year":"2025","unstructured":"Heo HS, Cho MH, Chung KS, Lee CW, Yoon YS, Lee SH, An HJ, Lee KT (2025) In vitro and in vivo anti-inflammatory and chondroprotective effects of standardized hot water extract from Hydrangea serrata (Thunb.) Ser. via modulation of NF-\u03baB and MAPK pathways. J Ethnopharmacol. https:\/\/doi.org\/10.1016\/j.jep.2025.120321","journal-title":"J Ethnopharmacol"},{"key":"2404_CR19","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2025.121023","volume":"358","author":"B Hou","year":"2026","unstructured":"Hou B, Xu A, Wen Y, Hua M, Ma X, Cui L, Zhu X, Cai W, Duoji B, Ji Y, Sun H (2026) Siwei Zangmu Xiang alleviates rheumatoid arthritis via regulating RAGE signaling pathway: integration of UPLC-Q-TOF-MS, network pharmacology, and in vivo\/in vitro studies. J Ethnopharmacol 358:121023. https:\/\/doi.org\/10.1016\/j.jep.2025.121023","journal-title":"J Ethnopharmacol"},{"key":"2404_CR20","doi-asserted-by":"publisher","unstructured":"Hu XX, Wu Y Jing Zhang J, and Wei W (2019). T-cells interact with B cells, dendritic cells, and fibroblast-like synoviocytes as hub-like key cells in rheumatoid arthritis. In International Immunopharmacology (Vol. 70, pp. 428\u2013434). Elsevier B.V. https:\/\/doi.org\/10.1016\/j.intimp.2019.03.008","DOI":"10.1016\/j.intimp.2019.03.008"},{"key":"2404_CR21","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2021.114853","author":"ATMR Islam","year":"2022","unstructured":"Islam ATMR, Hasan MM, Islam MT, Tanaka N (2022) Ethnobotanical study of plants used by the Munda ethnic group living around the Sundarbans, the world\u2019s largest mangrove forest in southwestern Bangladesh. J Ethnopharmacol. https:\/\/doi.org\/10.1016\/j.jep.2021.114853","journal-title":"J Ethnopharmacol"},{"key":"2404_CR22","doi-asserted-by":"publisher","unstructured":"Jayaraman A, Venkatachalapathy R, Prakash K, and Aruljothi KN (2026) Computational insights into the allosteric modulation of E. coli type 1 fimbriae by curcumin: FimH, FimG, FimF, FimA, FimD through docking, dynamics, DFT, MMGBSA analysis. J Mol Gr Modelling, 145. https:\/\/doi.org\/10.1016\/j.jmgm.2026.109351","DOI":"10.1016\/j.jmgm.2026.109351"},{"key":"2404_CR23","doi-asserted-by":"publisher","DOI":"10.3390\/ijms26031204","author":"ME Kim","year":"2025","unstructured":"Kim ME, Lee JS (2025) Advances in the regulation of inflammatory mediators in nitric oxide synthase: implications for disease modulation and therapeutic approaches. Int J Mol Sci. https:\/\/doi.org\/10.3390\/ijms26031204","journal-title":"Int J Mol Sci"},{"key":"2404_CR24","doi-asserted-by":"publisher","DOI":"10.1177\/11779322241233436","author":"MK Kingsley","year":"2024","unstructured":"Kingsley MK, Rao GK, Bhat BV (2024) Effectiveness of narciclasine in suppressing the inflammatory response in sepsis: molecular docking and in silico studies. Bioinf Biol Insights. https:\/\/doi.org\/10.1177\/11779322241233436","journal-title":"Bioinf Biol Insights"},{"key":"2404_CR25","doi-asserted-by":"publisher","DOI":"10.3390\/molecules25102337","author":"D Koutov\u00e1","year":"2020","unstructured":"Koutov\u00e1 D, Maafi N, Havelek R, Opletal L, Blunden G, \u0158ez\u00e1\u010dov\u00e1 M, Cahl\u00edkov\u00e1 L (2020) Chemical and biological aspects of montanine-type alkaloids isolated from plants of the Amaryllidaceae family. Molecules. https:\/\/doi.org\/10.3390\/molecules25102337","journal-title":"Molecules"},{"key":"2404_CR26","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpha.2025.101382","author":"J Kuai","year":"2025","unstructured":"Kuai J, Chen Z, He J, Wang F, Wei W (2025) Promising TNF-\u03b1 inhibitors: targeting pathogenic TNF-\u03b1\/TNFR signaling to restore Th17\/Treg balance in rheumatoid arthritis. J Pharm Anal. https:\/\/doi.org\/10.1016\/j.jpha.2025.101382","journal-title":"J Pharm Anal"},{"key":"2404_CR27","doi-asserted-by":"publisher","first-page":"283","DOI":"10.1016\/j.jep.2018.11.006","volume":"231","author":"C Lee","year":"2019","unstructured":"Lee C, Kim SY, Eum S, Paik JH, Bach TT, Darshetkar AM, Choudhary RK, Hai DV, Quang BH, Thanh NT, Choi S (2019) Ethnobotanical study on medicinal plants used by local Van Kieu ethnic people of Bac Huong Hoa nature reserve, Vietnam. J Ethnopharmacol 231:283\u2013294. https:\/\/doi.org\/10.1016\/j.jep.2018.11.006","journal-title":"J Ethnopharmacol"},{"key":"2404_CR28","doi-asserted-by":"publisher","unstructured":"Liang H, Li C, Wang Y, Hu Y, Zhao X, Luo N, Zhang Q, Li J, and Guo J (2026) Total flavonoids of Drynaria fortunei ameliorates rheumatoid arthritis by suppressing P. copri-mediated Th17 cell differentiation. J Ethnopharmacol, 358, 120970. https:\/\/doi.org\/10.1016\/j.jep.2025.120970","DOI":"10.1016\/j.jep.2025.120970"},{"key":"2404_CR29","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1016\/j.sajb.2020.06.004","volume":"136","author":"MF Mahomoodally","year":"2021","unstructured":"Mahomoodally MF, Sadeer NB, Suroowan S, Jugreet S, Lobine D, Rengasamy KRR (2021) Ethnomedicinal, phytochemistry, toxicity and pharmacological benefits of poison bulb \u2013 Crinum asiaticum L. S Afr J Bot 136:16\u201329. https:\/\/doi.org\/10.1016\/j.sajb.2020.06.004","journal-title":"S Afr J Bot"},{"key":"2404_CR30","doi-asserted-by":"publisher","first-page":"73","DOI":"10.2147\/OARRR.S523778","volume":"17","author":"A Mamasaidov","year":"2025","unstructured":"Mamasaidov A, Sakibaev K, Zhumabaeva S, Isakov U, Eshbaeva CA, Abdyllaev J, Abdikhalilov B, Salieva RS (2025) Impact of biological therapies on quality of life in rheumatoid arthritis: a narrative review. Open Access Rheumatol Res Rev 17:73\u201386. https:\/\/doi.org\/10.2147\/OARRR.S523778","journal-title":"Open Access Rheumatol Res Rev"},{"issue":"2","key":"2404_CR31","doi-asserted-by":"publisher","first-page":"106","DOI":"10.1007\/s40203-025-00386-6","volume":"13","author":"DR Martin","year":"2025","unstructured":"Martin DR, Ajmal A, Meyer M, Madiehe AM (2025) In silico identification of phytoconstituents from Capparis sepiaria as interleukin-1 inhibitors for rheumatoid arthritis: molecular docking, ADMET profiling, and molecular dynamics simulation. In Silico Pharmacol 13(2):106. https:\/\/doi.org\/10.1007\/s40203-025-00386-6","journal-title":"In Silico Pharmacol"},{"issue":"17","key":"2404_CR32","doi-asserted-by":"publisher","first-page":"8173","DOI":"10.3390\/ijms26178173","volume":"26","author":"V Mihaylova","year":"2025","unstructured":"Mihaylova V, Tomov D, Karalilova R, Batalov Z, Batalov A, Sarafian V, Kazakova M (2025) Effects of Methotrexate and tofacitinib on mitochondrial function and oxidative stress in human synovial cells in vitro. Int J Molr Sci 26(17):8173. https:\/\/doi.org\/10.3390\/ijms26178173","journal-title":"Int J Molr Sci"},{"key":"2404_CR33","doi-asserted-by":"publisher","first-page":"435","DOI":"10.1016\/j.sajb.2024.04.050","volume":"169","author":"O Mohanta","year":"2024","unstructured":"Mohanta O, Ray A, Gadnayak A, Champati BB, Jena S, Sahoo A, Das PK, Kamila PK, Nayak S, Panda PC (2024) Anisomeles indica (L.) Kuntze leaf essential oil ameliorates LPS-induced inflammation in RAW 264.7 cells: an integrated approach of network pharmacology and experimental validation. S Afr J Bot 169:435\u2013451. https:\/\/doi.org\/10.1016\/j.sajb.2024.04.050","journal-title":"S Afr J Bot"},{"key":"2404_CR34","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2024.e24120","author":"D Mohanty","year":"2024","unstructured":"Mohanty D, Padhee S, Sahoo C, Jena S, Sahoo A, Chandra Panda P, Nayak S, Ray A (2024) Integrating network pharmacology and experimental verification to decipher the multitarget pharmacological mechanism of Cinnamomum zeylanicum essential oil in treating inflammation. Heliyon. https:\/\/doi.org\/10.1016\/j.heliyon.2024.e24120","journal-title":"Heliyon"},{"issue":"4","key":"2404_CR35","doi-asserted-by":"publisher","first-page":"100","DOI":"10.1007\/s12032-025-02665-w","volume":"42","author":"D Mohanty","year":"2025","unstructured":"Mohanty D, Padhee S, Priyadarshini A, Kerry RG, Dash B, Sahoo A, Jena S, Panda PC, Khan HA, Nayak S, Ray A (2025) Integrative approach to decipher pharmacological mechanism of Cinnamomum zeylanicum essential oil in prostate cancer. Med Oncol 42(4):100. https:\/\/doi.org\/10.1007\/s12032-025-02665-w","journal-title":"Med Oncol"},{"key":"2404_CR36","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2024.117943","author":"JJ Nair","year":"2024","unstructured":"Nair JJ, van Staden J (2024) Anti-inflammatory effects of the plant family Amaryllidaceae. J Ethnopharmacol. https:\/\/doi.org\/10.1016\/j.jep.2024.117943","journal-title":"J Ethnopharmacol"},{"issue":"1","key":"2404_CR37","doi-asserted-by":"publisher","first-page":"85","DOI":"10.5114\/bta.2021.103765","volume":"102","author":"CJ Ononamadu","year":"2021","unstructured":"Ononamadu CJ, Ibrahim A (2021) Molecular docking and prediction of ADME\/drug-likeness properties of potentially active antidiabetic compounds isolated from aqueous-methanol extracts of Gymnema sylvestre and Combretum micranthum. Biotechnologia 102(1):85\u201399. https:\/\/doi.org\/10.5114\/bta.2021.103765","journal-title":"Biotechnologia"},{"key":"2404_CR38","doi-asserted-by":"publisher","unstructured":"Ouari S, Benzidane N, Merakeb MS, Bencharif C, Arrar L, and Bribi N (2025) Inula viscosa (L). Aiton leaves extract ameliorate arthritis by antioxidative and anti-inflammatory effects in formaldehyde-induced arthritis in mice. J Ethnopharmacol, 339. https:\/\/doi.org\/10.1016\/j.jep.2024.119154","DOI":"10.1016\/j.jep.2024.119154"},{"key":"2404_CR39","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2024.e35971","author":"S Padhee","year":"2024","unstructured":"Padhee S, Mohanty D, Sahoo A, Jena S, Chandra Panda P, Ray A, Nayak S (2024) Exploring the mechanism of action of Vanda tessellata extract for the treatment of osteoarthritis through network pharmacology, molecular modelling and experimental assays. Heliyon. https:\/\/doi.org\/10.1016\/j.heliyon.2024.e35971","journal-title":"Heliyon"},{"key":"2404_CR40","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2025.119637","author":"L Pan","year":"2025","unstructured":"Pan L, Zhou T, Maimaiti K, Xu H, Ma G (2025) Anti-rheumatoid arthritis effects of Caragana acanthophylla Kom. on collagen-induced arthritis and the anti-inflammatory activity of polyphenols as main active components. J Ethnopharmacol. https:\/\/doi.org\/10.1016\/j.jep.2025.119637","journal-title":"J Ethnopharmacol"},{"issue":"5","key":"2404_CR41","doi-asserted-by":"publisher","first-page":"176","DOI":"10.7324\/JAPS.2026.286618","volume":"16","author":"SK Pattanaik","year":"2026","unstructured":"Pattanaik SK, Pattanaik S, Pattanaik S, Jena S, Rath D (2026a) Modulation of inflammatory pathways by Caryota mitis in rheumatoid arthritis: in-vitro and in-vivo insights. J Appl Pharm Sci 16(5):176\u2013186. https:\/\/doi.org\/10.7324\/JAPS.2026.286618","journal-title":"J Appl Pharm Sci"},{"key":"2404_CR42","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2025.120854","author":"SK Pattanaik","year":"2026","unstructured":"Pattanaik SK, Sahoo S, Acharya SK, Barad PK, Pattanaik S, Rath D (2026b) Crateva magna (Lour.) DC ameliorates rheumatoid arthritis via TNF-signalling pathways: an integration of in-silico, in-vitro and in-vivo approach. J Ethnopharmacol. https:\/\/doi.org\/10.1016\/j.jep.2025.120854","journal-title":"J Ethnopharmacol"},{"issue":"16","key":"2404_CR43","doi-asserted-by":"publisher","first-page":"1536023","DOI":"10.3389\/fphar.2025.1536023","volume":"5","author":"Q Peng","year":"2025","unstructured":"Peng Q, Wang J, Li K, Xia C, Yao C, Guo Q, Gong X, Tang X, Jiang Q (2025) Effects of plant active substances in rheumatoid arthritis\u2014a systematic review and network meta-analysis. Front Pharmacol 5(16):1536023. https:\/\/doi.org\/10.3389\/fphar.2025.1536023","journal-title":"Front Pharmacol"},{"issue":"2","key":"2404_CR44","doi-asserted-by":"publisher","first-page":"799","DOI":"10.1007\/s10787-024-01589-7","volume":"33","author":"PM Pereira","year":"2025","unstructured":"Pereira PM, de Almeida-Junior S, de Melo Taveira NN, de Melo EM, Santos MFC, do Nascimento LCG, Rodrigues MA, Aldana-Mej\u00eda JA, Silva MLAe, Ambr\u00f3sio SR, Bastos JK, Ross SA, Furtado RA (2025) Therapeutic efficacy of brown propolis from Araucaria sp. in modulating rheumatoid arthritis. Inflammopharmacology 33(2):799\u2013807. https:\/\/doi.org\/10.1007\/s10787-024-01589-7","journal-title":"Inflammopharmacology"},{"key":"2404_CR45","doi-asserted-by":"publisher","unstructured":"Puppala ER, Prasad N, Prakash AN, Abubakar M, Syamprasad NP, Gangasani JK, and Naidu VGM (2024) Mesua assamica (King & Prain) kosterm. bark ethanolic extract attenuates rheumatoid arthritis via down-regulating TLR4\/NF-\u03baB\/COX-2\/iNOS and activation of Nrf2\/HO-1 pathways: a comprehensive study on in-vitro and in-vivo models. J Ethnopharmacol, 335, 118671. https:\/\/doi.org\/10.1016\/j.jep.2024.118671","DOI":"10.1016\/j.jep.2024.118671"},{"key":"2404_CR46","doi-asserted-by":"publisher","DOI":"10.3390\/cells10112857","author":"AF Radu","year":"2021","unstructured":"Radu AF, Bungau SG (2021) Management of rheumatoid arthritis: an overview. Cells. https:\/\/doi.org\/10.3390\/cells10112857","journal-title":"Cells"},{"key":"2404_CR47","doi-asserted-by":"publisher","first-page":"442","DOI":"10.1016\/j.jep.2016.09.026","volume":"192","author":"D Rath","year":"2016","unstructured":"Rath D, Kar DM, Panigrahi SK, Maharana L (2016) Antidiabetic effects of Cuscuta reflexa Roxb. in streptozotocin induced diabetic rats. J Ethnopharmacol 192:442\u2013449. https:\/\/doi.org\/10.1016\/j.jep.2016.09.026","journal-title":"J Ethnopharmacol"},{"issue":"1","key":"2404_CR48","doi-asserted-by":"publisher","first-page":"431","DOI":"10.1186\/s12951-024-02670-7","volume":"22","author":"S Ren","year":"2024","unstructured":"Ren S, Xu Y, Dong X, Mu Q, Chen X, Yu Y, Su G (2024) Nanotechnology-empowered combination therapy for rheumatoid arthritis: principles, strategies, and challenges. J Nanobiotechnol 22(1):431. https:\/\/doi.org\/10.1186\/s12951-024-02670-7","journal-title":"J Nanobiotechnol"},{"issue":"12","key":"2404_CR49","doi-asserted-by":"publisher","first-page":"7461","DOI":"10.1007\/s10787-025-01973-x","volume":"33","author":"A Rida","year":"2025","unstructured":"Rida A, Anjum F, Altwaijry N, Alshehri EH, Elsadek MF, Asif M (2025) Targeted suppression of cytokine-mediated inflammation in rheumatoid arthritis by Melia azedarach L. extract. Inflammopharmacology 33(12):7461\u20137478. https:\/\/doi.org\/10.1007\/s10787-025-01973-x","journal-title":"Inflammopharmacology"},{"key":"2404_CR50","doi-asserted-by":"publisher","DOI":"10.3390\/biom12101442","author":"SAA Rizvi","year":"2022","unstructured":"Rizvi SAA, Einstein GP, Tulp OL, Sainvil F, Branly R (2022) Introduction to traditional medicine and their role in prevention and treatment of emerging and re-emerging diseases. Biomolecules. https:\/\/doi.org\/10.3390\/biom12101442","journal-title":"Biomolecules"},{"key":"2404_CR51","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2021.689698","author":"VC Rom\u00e3o","year":"2021","unstructured":"Rom\u00e3o VC, Fonseca JE (2021) Etiology and risk factors for rheumatoid arthritis: a state-of-the-art review. Front Med. https:\/\/doi.org\/10.3389\/fmed.2021.689698","journal-title":"Front Med"},{"key":"2404_CR52","doi-asserted-by":"publisher","DOI":"10.1016\/j.humgen.2024.201364","author":"S Sabarathinam","year":"2025","unstructured":"Sabarathinam S, Venkatachalapathy R, Jayaraman A (2025) Metformin\u2019s modulation of gut microbiota and its implications for Non-Alcoholic Fatty Liver Disease (NAFLD): a network pharmacology and molecular dynamics study. Hum Gene Ther. https:\/\/doi.org\/10.1016\/j.humgen.2024.201364","journal-title":"Hum Gene Ther"},{"key":"2404_CR53","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2022.116076","volume":"304","author":"S Sahoo","year":"2023","unstructured":"Sahoo S, Rath D, Kar DM, Pattanaik S (2023) Hepatoprotective potency of Litsea glutinosa (L.) C.B. Rob. leaf methanol extract on H2O2-induced toxicity in HepG2 cells. J Ethnopharmacol 304:116076. https:\/\/doi.org\/10.1016\/j.jep.2022.116076","journal-title":"J Ethnopharmacol"},{"key":"2404_CR54","doi-asserted-by":"publisher","DOI":"10.1002\/cbdv.202501635","author":"S Sahoo","year":"2025","unstructured":"Sahoo S, Panda OA, Pattanaik SK, Pattanaik S, Ray A, Kar DM, Rath D (2025) Exploring the underlying mechanism of action of Lippia nodiflora on wound healing based on network pharmacology, molecular docking, and experimental validation. Chem Biodivers. https:\/\/doi.org\/10.1002\/cbdv.202501635","journal-title":"Chem Biodivers"},{"key":"2404_CR55","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2026.121517","volume":"364","author":"S Sahoo","year":"2026","unstructured":"Sahoo S, Pattanaik SK, Barad PK, Mahapatra JR, Acharya SK, Pattanaik S, Rath D (2026) Phytochemical profiling and system-level mechanistic insights into the anti-arthritic activity of Barleria cristata: evidence from in-silico network pharmacology, molecular docking, in-vitro and in-vivo studies. J Ethnopharmacol 364:121517. https:\/\/doi.org\/10.1016\/j.jep.2026.121517","journal-title":"J Ethnopharmacol"},{"key":"2404_CR56","doi-asserted-by":"publisher","unstructured":"Sahoo S, Khan HA, Kar DM, Pattanaik S, and Rath D (2024) LC-QTOF-MS\/MS metabolic profiling and hepatoprotective effects of Litsea monopetala bark methanol extract against liver injury in rats and HepG2 cells. Cell Mol Biol, 70(9), 156\u2013169. https:\/\/doi.org\/10.14715\/cmb\/2024.70.9.22","DOI":"10.14715\/cmb\/2024.70.9.22"},{"key":"2404_CR57","doi-asserted-by":"publisher","first-page":"937","DOI":"10.1016\/j.sajb.2022.04.055","volume":"149","author":"MK Shukla","year":"2022","unstructured":"Shukla MK, Singh SK, Pandey S, Gupta PK, Choudhary A, Jindal DK, Dua K, Kumar D (2022) Potential immunomodulatory activities of plant products. S Afr J Bot 149:937\u2013943. https:\/\/doi.org\/10.1016\/j.sajb.2022.04.055","journal-title":"S Afr J Bot"},{"issue":"8","key":"2404_CR58","doi-asserted-by":"publisher","first-page":"8771","DOI":"10.1096\/fj.201802440R","volume":"33","author":"A Stark","year":"2019","unstructured":"Stark A, Schwenk R, Wack G, Zuchtriegel G, Hatemler MG, Br\u00e4utigam J, Schmidtko A, Reichel CA, Bischoff I, F\u00fcrst R (2019) Narciclasine exerts anti-inflammatory actions by blocking leukocyte\u2013endothelial cell interactions and down-regulation of the endothelial TNF receptor 1. FASEB J 33(8):8771\u20138781. https:\/\/doi.org\/10.1096\/fj.201802440R","journal-title":"FASEB J"},{"issue":"1","key":"2404_CR59","doi-asserted-by":"publisher","first-page":"102036","DOI":"10.1016\/j.berh.2025.102036","volume":"39","author":"P Uke","year":"2025","unstructured":"Uke P, Maharaj A, Adebajo A (2025) A review on the epidemiology of rheumatoid arthritis: an update and trends from current literature. Best Practice Res Clinic Rheumatol 39(1):102036. https:\/\/doi.org\/10.1016\/j.berh.2025.102036","journal-title":"Best Practice Res Clinic Rheumatol"},{"issue":"224","key":"2404_CR60","doi-asserted-by":"publisher","first-page":"482","DOI":"10.1016\/j.jep.2018.06.018","volume":"5","author":"AM Uttra","year":"2018","unstructured":"Uttra AM, Shahzad M, Shabbir A, Jahan S (2018) Ephedra gerardiana aqueous ethanolic extract and fractions attenuate Freund Complete Adjuvant induced arthritis in Sprague Dawley rats by downregulating PGE2, COX2, IL-1\u03b2, IL-6, TNF-\u03b1, NF-kB and upregulating IL-4 and IL-10. J Ethnopharmacol 5(224):482\u2013496. https:\/\/doi.org\/10.1016\/j.jep.2018.06.018","journal-title":"J Ethnopharmacol"},{"issue":"1","key":"2404_CR61","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1016\/j.jaim.2017.09.007","volume":"11","author":"A Vysakh","year":"2020","unstructured":"Vysakh A, Jayesh K, Helen LR, Jyothis M, Latha MS (2020) Acute oral toxicity and anti-inflammatory evaluation of methanolic extract of Rotula aquatica roots in Wistar rats. J Ayurveda Integr Med 11(1):45\u201352. https:\/\/doi.org\/10.1016\/j.jaim.2017.09.007","journal-title":"J Ayurveda Integr Med"},{"key":"2404_CR62","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2024.119175","volume":"340","author":"F Wang","year":"2025","unstructured":"Wang F, Liu M, Tang Q, Sun H, Yang G, Sun J (2025a) Anti-rheumatic arthritis efficacy of Pueraria montana extract against type-II collagen-induced rheumatoid arthritis rat model an in vitro and in vivo assessment. J Ethnopharmacol 340:119175. https:\/\/doi.org\/10.1016\/j.jep.2024.119175","journal-title":"J Ethnopharmacol"},{"issue":"16","key":"2404_CR63","doi-asserted-by":"publisher","first-page":"1613679","DOI":"10.3389\/fphar.2025.1613679","volume":"6","author":"W Wang","year":"2025","unstructured":"Wang W, Wang Z, Ling A, Zhang C, Lv M, Huang L, Niu Y (2025b) Research progress in treatment of rheumatoid arthritis with Sinomenine and related formulations based on different administration routes. Front Pharmacol 6(16):1613679. https:\/\/doi.org\/10.3389\/fphar.2025.1613679","journal-title":"Front Pharmacol"},{"key":"2404_CR64","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2026.121796","author":"Z Wang","year":"2026","unstructured":"Wang Z, Xie X, Lei F, Gao J, Zhang Q, Li X, Tao Q, Xu Y (2026) Zhiwang decoction inhibits the inflammatory response and macrophage polarization in rheumatoid arthritis by mediating the PI3K\/AKT phosphorylation pathway through cellular communication network factor 1. J Ethnopharmacol. https:\/\/doi.org\/10.1016\/j.jep.2026.121796","journal-title":"J Ethnopharmacol"},{"issue":"6","key":"2404_CR65","doi-asserted-by":"publisher","first-page":"4993","DOI":"10.3892\/mmr.2019.10759","volume":"20","author":"J Yang","year":"2019","unstructured":"Yang J, Wang J, Liang X, Zhao H, Lu J, Ma Q, Jing B, Tian F (2019) IL-1\u03b2 increases the expression of inflammatory factors in synovial fluid-derived fibroblast-like synoviocytes via activation of the NF-\u03baB-mediated ERK-STAT1 signaling pathway. Mol Med Rep 20(6):4993\u20135001. https:\/\/doi.org\/10.3892\/mmr.2019.10759","journal-title":"Mol Med Rep"},{"issue":"1","key":"2404_CR66","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1186\/s12906-020-02909-4","volume":"20","author":"L Zhang","year":"2020","unstructured":"Zhang L, Shi X, Huang Z, Mao J, Mei W, Ding L, Zhang L, Xing R, Wang P (2020) Network pharmacology approach to uncover the mechanism governing the effect of radix achyranthis bidentatae on osteoarthritis. BMC Complement Med Ther 20(1):121. https:\/\/doi.org\/10.1186\/s12906-020-02909-4","journal-title":"BMC Complement Med Ther"},{"key":"2404_CR67","doi-asserted-by":"publisher","unstructured":"Zhang Y, Jin H, Jia W, Liu Y, Wang Y, Xue S, Liu Y, and Hao H (2025) Ermiao San attenuating rheumatoid arthritis via PI3K\/AKT\/mTOR signaling activate HIF-1\u03b1 induced glycolysis. J Ethnopharmacol, 345. https:\/\/doi.org\/10.1016\/j.jep.2025.119615","DOI":"10.1016\/j.jep.2025.119615"},{"key":"2404_CR68","doi-asserted-by":"publisher","unstructured":"Zhang Z, Gao X, Liu S, Wang Q, Wang Y, Hou S, Wang J, and Zhang Y (2025) Global, regional, and national epidemiology of rheumatoid arthritis among people aged 20\u201354\u00a0years from 1990 to 2021. Sci Rep, 15(1). https:\/\/doi.org\/10.1038\/s41598-025-92150-1","DOI":"10.1038\/s41598-025-92150-1"},{"key":"2404_CR69","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2026.121552","author":"Y Zhao","year":"2026","unstructured":"Zhao Y, Gao K, Zhao Y, Feng C, Liu H, Shi L, Sun W (2026) Shaoyao gancao decoction ameliorates rheumatoid arthritis via inhibition of TNF-\u03b1\/NF-\u03baB signaling pathway. J Ethnopharmacol. https:\/\/doi.org\/10.1016\/j.jep.2026.121552","journal-title":"J Ethnopharmacol"},{"issue":"2","key":"2404_CR70","doi-asserted-by":"publisher","first-page":"555","DOI":"10.3892\/mmr.2021.12194","volume":"24","author":"Y Zhao","year":"2021","unstructured":"Zhao Y, Chen Y, Wang J, Zhu X, Wang K, Li Y, Zhou F (2021) Ginkgolide J protects human synovial cells SW982 via suppression of p38-dependent production of pro-inflammatory mediators. Mol Med Rep 24(2):555. https:\/\/doi.org\/10.3892\/mmr.2021.12194","journal-title":"Mol Med Rep"}],"container-title":["Inflammopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10787-026-02404-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10787-026-02404-1","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10787-026-02404-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T08:16:41Z","timestamp":1790583401000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10787-026-02404-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,27]]},"references-count":70,"alternative-id":["2404"],"URL":"https:\/\/doi.org\/10.1007\/s10787-026-02404-1","relation":{},"ISSN":["0925-4692","1568-5608"],"issn-type":[{"value":"0925-4692","type":"print"},{"value":"1568-5608","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,27]]},"assertion":[{"value":"2 July 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 September 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 September 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare that they have no known conflict of interest or personal relationships that could have appeared to influence the work reported in this paper.","order":1,"name":"Ethics","label":"Conflict of interest","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Animal experimentation was performed strictly in accordance with institutional ethical regulations and was authorised by the IAEC under approval number IAEC\/SPS\/SOA\/275\/2025.","order":2,"name":"Ethics","label":"Ethical approval","group":{"name":"EthicsHeading","label":"Declarations"}}]}}