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Although the seeds represent a considerable portion of the whole fruit, scientific research on their phytochemistry and biological effects is still in its early stages. This study investigated the gastroprotective effect of the crude methanolic extract (CME-PA; 30\u2013300\u00a0mg\/kg), the fractions hexane (HF-PA; 100\u20131000\u00a0mg\/kg), dichloromethane (DCMF-PA; 30\u20131000\u00a0mg\/kg), and ethyl acetate (EAF-PA; 1000\u00a0mg\/kg) at doses proportional to their yields, as well as isolated compounds (\n                    <jats:bold>1<\/jats:bold>\n                    \u2013\n                    <jats:bold>4<\/jats:bold>\n                    ) and a mixture of compounds (\n                    <jats:bold>M<\/jats:bold>\n                    ). Gastroprotection was evaluated using the acidified ethanol-induced ulcer model. In addition, the study assessed histological, oxidative, and inflammatory parameters in the gastric mucosa, as well as the in vitro anti-\n                    <jats:italic>H. pylori<\/jats:italic>\n                    activity. Although CME-PA did not prevent the onset of gastric lesions, the HF-PA (300 and 1000\u00a0mg\/kg), DCMF-PA (1000\u00a0mg\/kg), and EAF-PA (1000\u00a0mg\/kg) fractions attenuated acidified ethanol\u2013induced injury by 56.73%, 74.93%, 80.53%, and 52.91%, respectively. Similarly, compounds\n                    <jats:bold>4<\/jats:bold>\n                    (300\u00a0mg\/kg) and\n                    <jats:bold>M<\/jats:bold>\n                    (1, 3, and 10\u00a0mg\/kg) reduced lesion formation by 52.16%, 56.02%, 66.90%, and 72.89%. Furthermore, compounds\n                    <jats:bold>4<\/jats:bold>\n                    (300\u00a0mg\/kg) and\n                    <jats:bold>M<\/jats:bold>\n                    (3\u00a0mg\/kg) increased PAS-stained mucin content. Notably, the mixture\n                    <jats:bold>M<\/jats:bold>\n                    , at all tested doses, enhanced the antioxidant defenses of the gastric mucosa and reduced inflammation. Despite these findings, the extract, fractions, and isolated compounds did not exhibit anti-\n                    <jats:italic>H. pylori<\/jats:italic>\n                    activity. Overall, this study provides promising phytochemical and pharmacological evidence, given the significant gastroprotective effects of fractions and isolated compounds against acidified ethanol\u2013induced gastric ulcers. These results highlight the potential of\n                    <jats:italic>P. americana<\/jats:italic>\n                    seeds, often regarded as a by-product of the fruit, as a valuable natural resource for the prevention of gastric ulcer disease.\n                  <\/jats:p>","DOI":"10.1007\/s10787-026-02419-8","type":"journal-article","created":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T16:37:16Z","timestamp":1791477436000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Gastroprotective potential of fatty compounds from Persea americana seed: an experimental report"],"prefix":"10.1007","author":[{"given":"Greice Rafaele","family":"Alves","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benhur Judah","family":"Cury","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruna","family":"Longo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandre","family":"Bella-Cruz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raphael Gilioli","family":"Heineck","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rafaela Carvalho","family":"Faustino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasmim Damian Pompeo","family":"Benevides","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luisa Mota","family":"da Silva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rivaldo","family":"Niero","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,10,8]]},"reference":[{"key":"2419_CR4","doi-asserted-by":"publisher","first-page":"e1900688","DOI":"10.1002\/mnfr.201900688","volume":"63","author":"N Ahmed","year":"2019","unstructured":"Ahmed N, Tcheng M, Roma A et al (2019) Avocatin B protects against lipotoxicity and improves insulin sensitivity in diet-induced obesity. 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