{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T19:47:26Z","timestamp":1777664846231,"version":"3.51.4"},"reference-count":22,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2016,2,27]],"date-time":"2016-02-27T00:00:00Z","timestamp":1456531200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Int Ophthalmol"],"published-print":{"date-parts":[[2016,12]]},"DOI":"10.1007\/s10792-016-0192-9","type":"journal-article","created":{"date-parts":[[2016,2,27]],"date-time":"2016-02-27T07:53:47Z","timestamp":1456559627000},"page":"841-844","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Histopathological changes on the ocular surface of New Zealand white rabbits after instillation of a fixed combination of 0.09\u00a0% xanthan gum and 0.1\u00a0% chondroitin sulfate"],"prefix":"10.1007","volume":"36","author":[{"given":"Ang\u00e9lica Y.","family":"Contreras-Rubio","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leopoldo","family":"Baiza-Dur\u00e1n","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oscar","family":"Olvera-Monta\u00f1o","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M\u00f3nica","family":"Miranda-Robles","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9","family":"Bonilla-Garc\u00eda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arieh","family":"Mercado-Sesma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2016,2,27]]},"reference":[{"key":"192_CR1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1159\/000131066","volume":"41","author":"J Tiffany","year":"2008","unstructured":"Tiffany J (2008) The normal tear film. Dev Ophthalmol 41:1\u201320","journal-title":"Dev Ophthalmol"},{"key":"192_CR2","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1111\/j.1444-0938.2011.00634.x","volume":"95","author":"U Stahl","year":"2012","unstructured":"Stahl U, Wilcox M, Stapleton F (2012) Osmolality and tear film dynamics. Clin Exp Optom 95:3\u201311","journal-title":"Clin Exp Optom"},{"key":"192_CR3","doi-asserted-by":"crossref","first-page":"1631","DOI":"10.1016\/j.jcrs.2007.06.019","volume":"33","author":"R Mont\u00e9s-Mic\u00f3","year":"2007","unstructured":"Mont\u00e9s-Mic\u00f3 R (2007) Role of the tear film in the optical quality of the human eye. J Cataract Refract Surg 33:1631\u20131635","journal-title":"J Cataract Refract Surg"},{"key":"192_CR4","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1097\/00003226-199811000-00002","volume":"17","author":"ME Stern","year":"1998","unstructured":"Stern ME, Beuerman RW, Fox RI, Gao J, Mircheff AK, Pflugfelder SC (1998) The pathology of dry eye: the interaction between the ocular surface and lacrimal glands. Cornea 17:584\u2013589","journal-title":"Cornea"},{"key":"192_CR5","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1007\/BF02159975","volume":"219","author":"M T\u00f6r\u00f6k","year":"1982","unstructured":"T\u00f6r\u00f6k M, S\u00fcveges I (1982) Morphological changes in dry eye syndrome. Graefes Arch Clin Exp Opthalmol 219:24\u201328","journal-title":"Graefes Arch Clin Exp Opthalmol"},{"key":"192_CR6","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1001\/archopht.120.3.330","volume":"120","author":"KS Kunet","year":"2002","unstructured":"Kunet KS, Tisdale AS, Gipson IK (2002) Goblet cell numbers and epithelial proliferation in the conjunctiva of patients with dry eye syndrome treated with cyclosporine. Arch Opthalmol 120:330\u2013337","journal-title":"Arch Opthalmol"},{"key":"192_CR7","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/j.jtos.2013.02.002","volume":"11","author":"M Alves","year":"2013","unstructured":"Alves M et al (2013) Dry eye disease treatment: a systematic review of published trials and a critical appraisal of therapeutic strategies. Ocul Surf 11:185\u2013192","journal-title":"Ocul Surf"},{"key":"192_CR8","first-page":"185","volume":"11","author":"TJ Liesegang","year":"2013","unstructured":"Liesegang TJ (2013) Viscoelastic substances in ophthalmology. Ocul Surf 11:185\u2013192","journal-title":"Ocul Surf"},{"key":"192_CR9","doi-asserted-by":"crossref","first-page":"3305","DOI":"10.1016\/S0142-9612(01)00167-3","volume":"22","author":"J Nepp","year":"2001","unstructured":"Nepp J et al (2001) The clinical use of viscoelastic artificial tears and sodium chloride in dry eye syndrome. Biomaterials 22:3305\u20133310","journal-title":"Biomaterials"},{"key":"192_CR10","first-page":"1329","volume":"25","author":"ME Hammer","year":"1984","unstructured":"Hammer ME, Burch TG (1984) Viscous corneal protection by sodium hyaluronate chondroitin sulfate, and methylcellulose. Investig Ophthalmol Vis Sci 25:1329\u20131332","journal-title":"Investig Ophthalmol Vis Sci"},{"key":"192_CR11","doi-asserted-by":"crossref","first-page":"42035","DOI":"10.1002\/app.42035","volume":"132","author":"DFS Petri","year":"2015","unstructured":"Petri DFS (2015) Xanthan gum: a versatile biopolymer for medical and technological applications. J Appl Polym Sci 132:42035","journal-title":"J Appl Polym Sci"},{"key":"192_CR12","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.ijbiomac.2013.08.024","volume":"62","author":"M Bhowmik","year":"2013","unstructured":"Bhowmik M, Kumari P, Sarkar G et al (2013) Effect of xanthan gum and guar gum on in situ gelling ophthalmic drug delivery system based on poloxamer-407. Int J Biol Macromol 62:117\u2013123","journal-title":"Int J Biol Macromol"},{"key":"192_CR13","doi-asserted-by":"crossref","first-page":"2553","DOI":"10.1167\/iovs.07-0069","volume":"48","author":"CS Paiva De","year":"2007","unstructured":"De Paiva CS, Villarreal AL, Corrales RM et al (2007) Dry Eye-induced conjunctival epithelial squamous metaplasia is modulated by interferon-\u03b3. Investig Ophthalmol Vis Sci 48:2553\u20132560","journal-title":"Investig Ophthalmol Vis Sci"},{"key":"192_CR14","first-page":"1419","volume":"8","author":"M Moshirfar","year":"2014","unstructured":"Moshirfar M, Pierson K, Hanamaikai K et al (2014) Artificial tears potpourri: a literature review. Clin Ophthalmol 8:1419\u20131433","journal-title":"Clin Ophthalmol"},{"key":"192_CR15","doi-asserted-by":"crossref","first-page":"1579","DOI":"10.1038\/eye.2012.211","volume":"26","author":"MQ Rahman","year":"2012","unstructured":"Rahman MQ, Chuah K-S, Macdonald ECA, Trusler JPM, Ramesh K (2012) The effect of pH, dilution, and temperature on the viscosity of ocular lubricants-shift in rheological parameters and potential clinical significance. Eye 26:1579\u20131584","journal-title":"Eye"},{"key":"192_CR16","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1016\/S0002-9394(14)74226-6","volume":"103","author":"MB Limberg","year":"1987","unstructured":"Limberg MB et al (1987) Topical application of hyaluronate acid and chondroitin sulfate in the treatment of dry eyes. Am J Ophthalmol 103:194\u2013197","journal-title":"Am J Ophthalmol"},{"key":"192_CR17","doi-asserted-by":"crossref","first-page":"3915","DOI":"10.4049\/jimmunol.147.11.3915","volume":"147","author":"J Stadler","year":"1991","unstructured":"Stadler J, Stefanovic-Racic M, Billiar TR et al (1991) Articular chondrocytes synthetize nitric oxide in response to cytokines and lipopolysaccharide. J Immunol 147:3915\u20133920","journal-title":"J Immunol"},{"key":"192_CR18","unstructured":"Amico C, Tornetta T, Scifo C, Blanco AR (2014) Antioxidant effect of 0.2\u00a0% xanthan gum in ocular surface corneal epithelial cells. Curr Eye Res, pp 1\u20135"},{"key":"192_CR19","first-page":"727","volume":"6","author":"F Faraldi","year":"2012","unstructured":"Faraldi F, Papa V, Santoro D et al (2012) A new eye gel containing sodium hyaluronate and xanthan gum for the management of post-traumatic corneal abrasions. Clin Ophthalmol 6:727\u2013731","journal-title":"Clin Ophthalmol"},{"key":"192_CR20","doi-asserted-by":"crossref","first-page":"189","DOI":"10.3341\/kjo.2007.21.4.189","volume":"21","author":"JW Moon","year":"2007","unstructured":"Moon JW, Lee HJ, Shin KC et al (2007) Short term effects of topical cyclosporine and viscoelastic on the ocular surfaces in patients with dry eye. Kor J Ophthalmol 21:189\u2013194","journal-title":"Kor J Ophthalmol"},{"key":"192_CR21","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/S0161-6420(97)30330-3","volume":"104","author":"SC Pflugfelder","year":"1997","unstructured":"Pflugfelder SC, Tseng SC, Yoshino K et al (1997) Correlation of goblet cell density and mucosal epithelial membrane mucin expression with rose Bengal staining in patients with ocular irritation. Ophthalmology 104:223\u2013235","journal-title":"Ophthalmology"},{"issue":"4","key":"192_CR22","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.1002\/jps.10106","volume":"91","author":"J Ceulemans","year":"2002","unstructured":"Ceulemans J, Vinckier I, Ludwig A (2002) The use of xanthan gum in an ophthalmic liquid dosage form: rheological characterization of the interaction with mucin. J Pharm Sci 91(4):1117\u20131127","journal-title":"J Pharm Sci"}],"container-title":["International Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10792-016-0192-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s10792-016-0192-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10792-016-0192-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10792-016-0192-9","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,14]],"date-time":"2024-06-14T17:11:10Z","timestamp":1718385070000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s10792-016-0192-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,2,27]]},"references-count":22,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2016,12]]}},"alternative-id":["192"],"URL":"https:\/\/doi.org\/10.1007\/s10792-016-0192-9","relation":{},"ISSN":["0165-5701","1573-2630"],"issn-type":[{"value":"0165-5701","type":"print"},{"value":"1573-2630","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,2,27]]}}}