{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,3]],"date-time":"2026-03-03T21:08:03Z","timestamp":1772572083471,"version":"3.50.1"},"reference-count":43,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2017,11,20]],"date-time":"2017-11-20T00:00:00Z","timestamp":1511136000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Int Ophthalmol"],"published-print":{"date-parts":[[2018,12]]},"DOI":"10.1007\/s10792-017-0768-z","type":"journal-article","created":{"date-parts":[[2017,11,20]],"date-time":"2017-11-20T09:53:50Z","timestamp":1511171630000},"page":"2553-2562","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Comparison of the neuroprotective effects of brimonidine tartrate and melatonin on retinal ganglion cells"],"prefix":"10.1007","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6261-1021","authenticated-orcid":false,"given":"Deniz","family":"Marangoz","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elif","family":"Guzel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Signem","family":"Eyuboglu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Asli","family":"Gumusel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ismail","family":"Seckin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ferda","family":"Ciftci","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bayram","family":"Yilmaz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ilgaz","family":"Yalvac","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2017,11,20]]},"reference":[{"key":"768_CR1","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1136\/bjo.2005.081224","volume":"90","author":"HA Quigley","year":"2006","unstructured":"Quigley HA, Broman AT (2006) The number of people with glaucoma worldwide in 2010 and 2020. Br J Ophthalmol 90:262\u2013267","journal-title":"Br J Ophthalmol"},{"key":"768_CR2","doi-asserted-by":"crossref","first-page":"2265","DOI":"10.1016\/j.ophtha.2007.02.005","volume":"114","author":"PY Ramulu","year":"2007","unstructured":"Ramulu PY, Corcoran KJ, Corcoran SL, Robin AL (2007) Utilization of various glaucoma surgeries and procedures in Medicare beneficiaries from 1995 to 2004. Ophthalmology 114:2265\u20132270","journal-title":"Ophthalmology"},{"key":"768_CR3","first-page":"2849","volume":"42","author":"E WoldeMussie","year":"2001","unstructured":"WoldeMussie E, Ruiz G, Wijono M, Wheeler LA (2001) Neuroprotection of retinal ganglion cells by brimonidine in rats with laser-induced chronic ocular hypertension. Invest Ophthalmol Vis Sci 42:2849\u20132855","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"768_CR4","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1001\/archopht.121.1.48","volume":"121","author":"MC Leske","year":"2003","unstructured":"Leske MC, Heijl A, Hussein M, Bengtsson B, Hyman L, Komaroff E (2003) Factors for glaucoma progression and the effect of treatment: the early manifest glaucoma trial. Arch Ophthalmol 121:48\u201356","journal-title":"Arch Ophthalmol"},{"key":"768_CR5","doi-asserted-by":"crossref","first-page":"1268","DOI":"10.1001\/archopht.120.10.1268","volume":"120","author":"A Heijl","year":"2002","unstructured":"Heijl A, Leske MC, Bengtsson B, Hyman L, Bengtsson B, Hussein M (2002) Reduction of intraocular pressure and glaucoma progression: results from the Early Manifest Glaucoma Trial. Arch Ophthalmol 120:1268\u20131279","journal-title":"Arch Ophthalmol"},{"key":"768_CR6","first-page":"65","volume":"40","author":"E Yoles","year":"1999","unstructured":"Yoles E, Wheeler LA, Schwartz M (1999) Alpha2-adrenoreceptor agonists are neuroprotective in a rat model of optic nerve degeneration. Invest Ophthalmol Vis Sci 40:65\u201373","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"Suppl 1","key":"768_CR7","doi-asserted-by":"crossref","first-page":"S47","DOI":"10.1016\/S0039-6257(03)00004-3","volume":"48","author":"L Wheeler","year":"2003","unstructured":"Wheeler L, WoldeMussie E, Lai R (2003) Role of alpha-2 agonists in neuroprotection. Surv Ophthalmol 48(Suppl 1):S47\u2013S51","journal-title":"Surv Ophthalmol"},{"key":"768_CR8","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1016\/S0022-3565(24)29683-X","volume":"296","author":"JE Donello","year":"2001","unstructured":"Donello JE, Padillo EU, Webster ML, Wheeler LA, Gil DW (2001) \u03b1(2)-Adrenoceptor agonists inhibit vitreal glutamate and aspartate accumulation and preserve retinal function after transient ischemia. J Pharmacol Exp Ther 296:216\u2013223","journal-title":"J Pharmacol Exp Ther"},{"key":"768_CR9","first-page":"2074","volume":"42","author":"MP Lafuente","year":"2001","unstructured":"Lafuente MP, Villegas-Perez MP, Sobrado-Calvo P, Garcia-Aviles A, Miralles de Imperial J, Vidal-Sanz M (2001) Neuroprotective effects of \u03b1(2)-selective adrenergic agonists against ischemia-induced retinal ganglion cell death. Invest Ophthalmol Vis Sci 42:2074\u20132084","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"325\u2013327","key":"768_CR10","first-page":"e1","volume":"142","author":"C Chiquet","year":"2006","unstructured":"Chiquet C, Claustrat B, Thuret G, Brun J, Cooper HM, Denis P (2006) Melatonin concentrations in aqueous humor of glaucoma patients. Am J Ophthalmol 142(325\u2013327):e1","journal-title":"Am J Ophthalmol"},{"key":"768_CR11","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1002\/bies.20777","volume":"30","author":"G Tosini","year":"2008","unstructured":"Tosini G, Pozdeyev N, Sakamoto K, Iuvone PM (2008) The circadian clock system in the mammalian retina. BioEssays 30:624\u2013633","journal-title":"BioEssays"},{"key":"768_CR12","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.smrv.2004.05.002","volume":"9","author":"J Arendt","year":"2005","unstructured":"Arendt J, Skene DJ (2005) Melatonin as a chronobiotic. Sleep Med Rev 9:25\u201339","journal-title":"Sleep Med Rev"},{"key":"768_CR13","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1016\/j.pneurobio.2010.12.004","volume":"93","author":"R Hardeland","year":"2011","unstructured":"Hardeland R, Cardinali DP, Srinivasan V, Spence DW, Brown GM, Pandi-Perumal SR (2011) Melatonin\u2014a pleiotropic, orchestrating regulator molecule. Prog Neurobiol 93:350\u2013384","journal-title":"Prog Neurobiol"},{"key":"768_CR14","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1046\/j.1365-2826.2001.00627.x","volume":"13","author":"PO Castrillon","year":"2001","unstructured":"Castrillon PO, Cardinali DP, Pazo D, Cutrera RA, Esquifino AI (2001) Effect of superior cervical ganglionectomy on 24-h variations in hormone secretion from the anterior hypophysis and in hypothalamic monoamine turnover during the preclinical phase of Freund\u2019s adjuvant arthritis in rats. J Neuroendocrinol 13:288\u2013295","journal-title":"J Neuroendocrinol"},{"key":"768_CR15","doi-asserted-by":"crossref","first-page":"116","DOI":"10.4068\/cmj.2012.48.2.116","volume":"48","author":"SW Park","year":"2012","unstructured":"Park SW, Lee HS, Sung MS, Kim SJ (2012) The effect of melatonin on retinal ganglion cell survival in ischemic retina. Chonnam Med J 48:116\u2013122","journal-title":"Chonnam Med J"},{"key":"768_CR16","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1124\/jpet.112.202036","volume":"346","author":"A Crooke","year":"2013","unstructured":"Crooke A, Huete-Toral F, Martinez-Aguila A, Martin-Gil A, Pintor J (2013) Melatonin and its analog 5-methoxycarbonylamino-N-acetyltryptamine potentiate adrenergic receptor-mediated ocular hypotensive effects in rabbits: significance for combination therapy in glaucoma. J Pharmacol Exp Ther 346:138\u2013145","journal-title":"J Pharmacol Exp Ther"},{"key":"768_CR17","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1124\/jpet.115.231456","volume":"357","author":"A Martinez-Aguila","year":"2016","unstructured":"Martinez-Aguila A, Fonseca B, Perez de Lara MJ, Pintor J (2016) Effect of melatonin and 5-Methoxycarbonylamino-N-Acetyltryptamine on the intraocular pressure of normal and glaucomatous mice. J Pharmacol Exp Ther 357:293\u2013299","journal-title":"J Pharmacol Exp Ther"},{"key":"768_CR18","doi-asserted-by":"crossref","first-page":"75","DOI":"10.18097\/pbmc20176301075","volume":"63","author":"NB Chesnokova","year":"2017","unstructured":"Chesnokova NB, Beznos OV, Lozinskaya NA et al (2017) Novel agonists of melatonin receptors as promising hypotensive and neuroprotective agents for therapy of glaucoma. Biomed Khim 63:75\u201380","journal-title":"Biomed Khim"},{"key":"768_CR19","doi-asserted-by":"crossref","first-page":"2180","DOI":"10.1038\/npp.2009.46","volume":"34","author":"G Ramirez-Rodriguez","year":"2009","unstructured":"Ramirez-Rodriguez G, Klempin F, Babu H, Benitez-King G, Kempermann G (2009) Melatonin modulates cell survival of new neurons in the hippocampus of adult mice. Neuropsychopharmacology 34:2180\u20132191","journal-title":"Neuropsychopharmacology"},{"key":"768_CR20","doi-asserted-by":"crossref","first-page":"62","DOI":"10.2500\/ajra.2016.30.4313","volume":"30","author":"S Koc","year":"2016","unstructured":"Koc S, Cayli S, Aksakal C et al (2016) Protective effects of melatonin and selenium against apoptosis of olfactory sensory neurons: a rat model study. Am J Rhinol Allergy 30:62\u201366","journal-title":"Am J Rhinol Allergy"},{"key":"768_CR21","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/j.neuropharm.2015.07.014","volume":"99","author":"I Buendia","year":"2015","unstructured":"Buendia I, Gomez-Rangel V, Gonzalez-Lafuente L et al (2015) Neuroprotective mechanism of the novel melatonin derivative Neu-P11 in brain ischemia related models. Neuropharmacology 99:187\u2013195","journal-title":"Neuropharmacology"},{"key":"768_CR22","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.neulet.2008.08.024","volume":"444","author":"PO Koh","year":"2008","unstructured":"Koh PO (2008) Melatonin prevents ischemic brain injury through activation of the mTOR\/p70S6 kinase signaling pathway. Neurosci Lett 444:74\u201378","journal-title":"Neurosci Lett"},{"key":"768_CR23","doi-asserted-by":"crossref","first-page":"1307","DOI":"10.1096\/fasebj.14.10.1307","volume":"14","author":"CV Borlongan","year":"2000","unstructured":"Borlongan CV, Yamamoto M, Takei N et al (2000) Glial cell survival is enhanced during melatonin-induced neuroprotection against cerebral ischemia. Faseb J 14:1307\u20131317","journal-title":"Faseb J"},{"key":"768_CR24","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/j.neulet.2004.08.068","volume":"371","author":"B Chetsawang","year":"2004","unstructured":"Chetsawang B, Govitrapong P, Ebadi M (2004) The neuroprotective effect of melatonin against the induction of c-Jun phosphorylation by 6-hydroxydopamine on SK-N-SH cells. Neurosci Lett 371:205\u2013208","journal-title":"Neurosci Lett"},{"key":"768_CR25","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1111\/j.1600-079X.1998.tb00380.x","volume":"25","author":"JC Mayo","year":"1998","unstructured":"Mayo JC, Sainz RM, Uria H, Antolin I, Esteban MM, Rodriguez C (1998) Inhibition of cell proliferation: a mechanism likely to mediate the prevention of neuronal cell death by melatonin. J Pineal Res 25:12\u201318","journal-title":"J Pineal Res"},{"issue":"7","key":"768_CR26","doi-asserted-by":"crossref","first-page":"1010","DOI":"10.2174\/1570159X15666170313123454","volume":"15","author":"M Shukla","year":"2017","unstructured":"Shukla M, Boontem P, Reiter RJ, Satayavivad J, Govitrapong P (2017) Mechanisms of melatonin in alleviating alzheimer\u2019s disease. Curr Neuropharmacol 15(7):1010\u20131031","journal-title":"Curr Neuropharmacol"},{"key":"768_CR27","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1111\/j.1600-079X.2006.00377.x","volume":"41","author":"JH Weishaupt","year":"2006","unstructured":"Weishaupt JH, Bartels C, Polking E et al (2006) Reduced oxidative damage in ALS by high-dose enteral melatonin treatment. J Pineal Res 41:313\u2013323","journal-title":"J Pineal Res"},{"key":"768_CR28","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1016\/j.neulet.2005.05.055","volume":"385","author":"D Ozdemir","year":"2005","unstructured":"Ozdemir D, Tugyan K, Uysal N et al (2005) Protective effect of melatonin against head trauma-induced hippocampal damage and spatial memory deficits in immature rats. Neurosci Lett 385:234\u2013239","journal-title":"Neurosci Lett"},{"key":"768_CR29","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1038\/sj.sc.3101508","volume":"41","author":"SF Erten","year":"2003","unstructured":"Erten SF, Kocak A, Ozdemir I, Aydemir S, Colak A, Reeder BS (2003) Protective effect of melatonin on experimental spinal cord ischemia. Spinal Cord 41:533\u2013538","journal-title":"Spinal Cord"},{"key":"768_CR30","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1006\/exnr.2001.7793","volume":"172","author":"MC Lee","year":"2001","unstructured":"Lee MC, Chung YT, Lee JH, Jung JJ, Kim HS, Kim SU (2001) Antioxidant effect of melatonin in human retinal neuron cultures. Exp Neurol 172:407\u2013415","journal-title":"Exp Neurol"},{"key":"768_CR31","doi-asserted-by":"crossref","first-page":"1078","DOI":"10.1136\/bjo.2003.037879","volume":"88","author":"AW Siu","year":"2004","unstructured":"Siu AW, Ortiz GG, Benitez-King G, To CH, Reiter RJ (2004) Effects of melatonin on the nitric oxide treated retina. Br J Ophthalmol 88:1078\u20131081","journal-title":"Br J Ophthalmol"},{"key":"768_CR32","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/j.neulet.2013.05.058","volume":"548","author":"E Dardiotis","year":"2013","unstructured":"Dardiotis E, Panayiotou E, Feldman ML et al (2013) Intraperitoneal melatonin is not neuroprotective in the G93ASOD1 transgenic mouse model of familial ALS and may exacerbate neurodegeneration. Neurosci Lett 548:170\u2013175","journal-title":"Neurosci Lett"},{"key":"768_CR33","doi-asserted-by":"crossref","first-page":"798","DOI":"10.1016\/j.exer.2008.02.008","volume":"86","author":"M Hernandez","year":"2008","unstructured":"Hernandez M, Urcola JH, Vecino E (2008) Retinal ganglion cell neuroprotection in a rat model of glaucoma following brimonidine, latanoprost or combined treatments. Exp Eye Res 86:798\u2013806","journal-title":"Exp Eye Res"},{"issue":"8","key":"768_CR34","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1111\/j.1442-9071.2011.02573.x","volume":"39","author":"S Pinar-Sueiro","year":"2011","unstructured":"Pinar-Sueiro S, Urcola H, Rivas MA, Vecino E (2011) Prevention of retinal ganglion cell swelling by systemic brimonidine in a rat experimental glaucoma model. Clin Exp Ophthalmol 39(8):799\u2013807","journal-title":"Clin Exp Ophthalmol"},{"issue":"3","key":"768_CR35","first-page":"340","volume":"9","author":"M Unlu","year":"2016","unstructured":"Unlu M, Aktas Z, Gocun PU, Ilhan SO, Hasanreisoglu M, Hasanreisoglu B (2016) Neuroprotective effect of systemic and\/or intravitreal rosuvastatin administration in rat glaucoma model. Int J Ophthalmol 9(3):340\u2013347","journal-title":"Int J Ophthalmol"},{"key":"768_CR36","first-page":"3451","volume":"41","author":"TW Mittag","year":"2000","unstructured":"Mittag TW, Danias J, Pohorenec G et al (2000) Retinal damage after 3 to 4\u00a0months of elevated intraocular pressure in a rat glaucoma model. Invest Ophthalmol Vis Sci 41:3451\u20133459","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"768_CR37","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1186\/1750-1326-6-4","volume":"6","author":"WS Lambert","year":"2011","unstructured":"Lambert WS, Ruiz L, Crish SD, Wheeler LA, Calkins DJ (2011) Brimonidine prevents axonal and somatic degeneration of retinal ganglion cell neurons. Mol Neurodegener 6:4","journal-title":"Mol Neurodegener"},{"key":"768_CR38","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1097\/ICU.0b013e32834372ec","volume":"22","author":"HV Danesh-Meyer","year":"2011","unstructured":"Danesh-Meyer HV (2011) Neuroprotection in glaucoma: recent and future directions. Curr Opin Ophthalmol 22:78\u201386","journal-title":"Curr Opin Ophthalmol"},{"key":"768_CR39","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1001\/archopht.120.6.797","volume":"120","author":"H Gao","year":"2002","unstructured":"Gao H, Qiao X, Cantor LB, WuDunn D (2002) Up-regulation of brain-derived neurotrophic factor expression by brimonidine in rat retinal ganglion cells. Arch Ophthalmol 120:797\u2013803","journal-title":"Arch Ophthalmol"},{"key":"768_CR40","doi-asserted-by":"crossref","first-page":"4515","DOI":"10.1167\/iovs.08-2078","volume":"49","author":"CJ Dong","year":"2008","unstructured":"Dong CJ, Guo Y, Agey P, Wheeler L, Hare WA (2008) \u03b12 adrenergic modulation of NMDA receptor function as a major mechanism of RGC protection in experimental glaucoma and retinal excitotoxicity. Invest Ophthalmol Vis Sci 49:4515\u20134522","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"768_CR41","first-page":"246","volume":"16","author":"KY Lee","year":"2010","unstructured":"Lee KY, Nakayama M, Aihara M, Chen YN, Araie M (2010) Brimonidine is neuroprotective against glutamate-induced neurotoxicity, oxidative stress, and hypoxia in purified rat retinal ganglion cells. Mol Vis 16:246\u2013251","journal-title":"Mol Vis"},{"key":"768_CR42","doi-asserted-by":"crossref","first-page":"15043","DOI":"10.1073\/pnas.0904400106","volume":"106","author":"K Baba","year":"2009","unstructured":"Baba K, Pozdeyev N, Mazzoni F et al (2009) Melatonin modulates visual function and cell viability in the mouse retina via the MT1 melatonin receptor. Proc Natl Acad Sci USA 106:15043\u201315048","journal-title":"Proc Natl Acad Sci USA"},{"key":"768_CR43","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.neulet.2011.02.056","volume":"494","author":"S Alcantara-Contreras","year":"2011","unstructured":"Alcantara-Contreras S, Baba K, Tosini G (2011) Removal of melatonin receptor type 1 increases intraocular pressure and retinal ganglion cells death in the mouse. Neurosci Lett 494:61\u201364","journal-title":"Neurosci Lett"}],"container-title":["International Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s10792-017-0768-z\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10792-017-0768-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10792-017-0768-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,27]],"date-time":"2025-06-27T04:49:42Z","timestamp":1750999782000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s10792-017-0768-z"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,11,20]]},"references-count":43,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2018,12]]}},"alternative-id":["768"],"URL":"https:\/\/doi.org\/10.1007\/s10792-017-0768-z","relation":{},"ISSN":["0165-5701","1573-2630"],"issn-type":[{"value":"0165-5701","type":"print"},{"value":"1573-2630","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,11,20]]}}}