{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T22:18:30Z","timestamp":1792189110371,"version":"4.4.0"},"reference-count":21,"publisher":"Springer Science and Business Media LLC","issue":"12","license":[{"start":{"date-parts":[[2019,6,18]],"date-time":"2019-06-18T00:00:00Z","timestamp":1560816000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2019,6,18]],"date-time":"2019-06-18T00:00:00Z","timestamp":1560816000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Int Ophthalmol"],"published-print":{"date-parts":[[2019,12]]},"DOI":"10.1007\/s10792-019-01137-1","type":"journal-article","created":{"date-parts":[[2019,6,18]],"date-time":"2019-06-18T17:02:33Z","timestamp":1560877353000},"page":"2889-2896","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Therapeutic penetrating keratoplasty for acanthamoeba keratitis: a review of cases, complications and predictive factors"],"prefix":"10.1007","volume":"39","author":[{"given":"Mehdi","family":"Roozbahani","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristin M.","family":"Hammersmith","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher J.","family":"Rapuano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Parveen K.","family":"Nagra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiang","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2019,6,18]]},"reference":[{"key":"1137_CR1","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/484892","author":"B Clarke","year":"2012","unstructured":"Clarke B, Sinha A, Parmar DN, Sykakis E (2012) Advances in the diagnosis and treatment of acanthamoeba keratitis. J Ophthalmol. \nhttps:\/\/doi.org\/10.1155\/2012\/484892","journal-title":"J Ophthalmol"},{"key":"1137_CR2","doi-asserted-by":"publisher","first-page":"713","DOI":"10.1097\/ICO.0000000000000804","volume":"35","author":"NJ Maycock","year":"2016","unstructured":"Maycock NJ, Jayaswal R (2016) Update on acanthamoeba keratitis: diagnosis, treatment, and outcomes. Cornea 35:713\u2013720","journal-title":"Cornea"},{"key":"1137_CR3","doi-asserted-by":"publisher","first-page":"1431","DOI":"10.1136\/bjophthalmol-2017-310806","volume":"102","author":"N Carnt","year":"2018","unstructured":"Carnt N, Robaei D, Minassian DC, Dart JKG (2018) Acanthamoeba keratitis in 194 patients: risk factors for bad outcomes and severe inflammatory complications. B J Ophthalmol 102:1431\u20131435","journal-title":"B J Ophthalmol"},{"key":"1137_CR4","doi-asserted-by":"publisher","first-page":"435","DOI":"10.1097\/ICO.0b013e3181ec905f","volume":"30","author":"HF Chew","year":"2011","unstructured":"Chew HF, Yildiz EH, Hammersmith KM, Eagle RC Jr, Rapuano CJ, Laibson PR et al (2011) Clinical outcomes and prognostic factors associated with acanthamoeba keratitis. Cornea 30:435\u2013441","journal-title":"Cornea"},{"key":"1137_CR5","doi-asserted-by":"publisher","first-page":"164","DOI":"10.1016\/j.jtos.2015.01.002","volume":"13","author":"C Jiang","year":"2015","unstructured":"Jiang C, Sun X, Wang Z, Zhang Y (2015) Acanthamoeba keratitis: clinical characteristics and management. Ocular Surf 13:164\u2013168","journal-title":"Ocular Surf"},{"key":"1137_CR6","doi-asserted-by":"publisher","first-page":"1383","DOI":"10.1016\/j.ophtha.2014.01.031","volume":"121","author":"D Robaei","year":"2014","unstructured":"Robaei D, Carnt N, Minassian DC, Dart JK (2014) The impact of topical corticosteroid use before diagnosis on the outcome of acanthamoeba keratitis. Ophthalmology 121:1383\u20131388","journal-title":"Ophthalmology"},{"key":"1137_CR7","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1016\/j.ophtha.2014.07.052","volume":"122","author":"D Robaei","year":"2015","unstructured":"Robaei D, Carnt N, Minassian DC, Dart JK (2015) Therapeutic and optical keratoplasty in the management of acanthamoeba keratitis: risk factors, outcomes, and summary of the literature. Ophthalmology 122:17\u201324","journal-title":"Ophthalmology"},{"key":"1137_CR8","doi-asserted-by":"publisher","first-page":"130","DOI":"10.1097\/ICO.0b013e31826429bd","volume":"32","author":"N Bouheraoua","year":"2013","unstructured":"Bouheraoua N, Gaujoux T, Goldschmidt P, Chaumeil C, Laroche L, Borderie VM (2013) Prognostic factors associated with the need for surgical treatments in acanthamoeba keratitis. Cornea 32:130\u2013136","journal-title":"Cornea"},{"key":"1137_CR9","doi-asserted-by":"publisher","first-page":"1080","DOI":"10.1016\/j.ajo.2005.07.031","volume":"140","author":"ST Awwad","year":"2005","unstructured":"Awwad ST, Parmar DN, Heilman M, Bowman RW, McCulley JP, Cavanagh HD (2005) Results of penetrating keratoplasty for visual rehabilitation after acanthamoeba keratitis. A J Ophthalmol 140:1080\u20131084","journal-title":"A J Ophthalmol"},{"key":"1137_CR10","doi-asserted-by":"publisher","first-page":"864","DOI":"10.1016\/j.ophtha.2008.12.029","volume":"116","author":"AS Kitzmann","year":"2009","unstructured":"Kitzmann AS, Goins KM, Sutphin JE, Wagoner MD (2009) Keratoplasty for treatment of acanthamoeba keratitis. Ophthalmology 116:864\u2013869","journal-title":"Ophthalmology"},{"key":"1137_CR11","first-page":"736","volume":"137","author":"WL Chen","year":"2004","unstructured":"Chen WL, Wu CY, Hu FR, Wang IJ (2004) Therapeutic penetrating keratoplasty for microbial keratitis in Taiwan from 1987 to 2001. A J Ophthalmol 137:736\u2013743","journal-title":"A J Ophthalmol"},{"key":"1137_CR12","doi-asserted-by":"publisher","first-page":"666","DOI":"10.1111\/j.1600-0420.2007.01086.x","volume":"86","author":"RT Kashiwabuchi","year":"2008","unstructured":"Kashiwabuchi RT, de Freitas D, Alvarenga LS, Vieira L, Contarini P, Sato E et al (2008) Corneal graft survival after therapeutic keratoplasty for acanthamoeba keratitis. Acta Ophthalmol 86:666\u2013669","journal-title":"Acta Ophthalmol"},{"key":"1137_CR13","first-page":"2885","volume":"42","author":"K McClellan","year":"2001","unstructured":"McClellan K, Howard K, Niederkorn JY, Alizadeh H (2001) Effect of steroids on acanthamoeba cysts and trophozoites. Invest Ophthalmol Visual Sci 42:2885\u20132893","journal-title":"Invest Ophthalmol Visual Sci"},{"key":"1137_CR14","doi-asserted-by":"publisher","first-page":"2299","DOI":"10.2147\/OPTH.S92176","volume":"9","author":"L Bajracharya","year":"2015","unstructured":"Bajracharya L, Gurung R (2015) Outcome of therapeutic penetrating keratoplasty in a tertiary eye care center in Nepal. Clin Ophthalmol 9:2299\u20132304","journal-title":"Clin Ophthalmol"},{"key":"1137_CR15","doi-asserted-by":"publisher","first-page":"739","DOI":"10.1097\/ICO.0b013e318203217c","volume":"30","author":"LS Lim","year":"2011","unstructured":"Lim LS, Arundhati A, Tan DT (2011) Sequential therapeutic penetrating keratoplasty with cryopreserved and fresh corneal tissue for severe infectious keratitis: a case-control study. Cornea 30:739\u2013743","journal-title":"Cornea"},{"key":"1137_CR16","doi-asserted-by":"publisher","first-page":"529","DOI":"10.1016\/j.jcjo.2013.05.017","volume":"48","author":"Y Liu","year":"2013","unstructured":"Liu Y, Jia H, Shi X, Wang J, Ning Y, He B et al (2013) Minimal trephination penetrating keratoplasty for severe fungal keratitis complicated with hypopyon. Can J Ophthalmol 48:529\u2013534","journal-title":"Can J Ophthalmol"},{"key":"1137_CR17","doi-asserted-by":"publisher","first-page":"755","DOI":"10.1016\/j.ajo.2007.01.015","volume":"143","author":"SE Ti","year":"2007","unstructured":"Ti SE, Scott JA, Janardhanan P, Tan DT (2007) Therapeutic keratoplasty for advanced suppurative keratitis. A J Ophthalmol 143:755\u2013762","journal-title":"A J Ophthalmol"},{"key":"1137_CR18","doi-asserted-by":"publisher","first-page":"668","DOI":"10.1016\/j.ophtha.2011.10.016","volume":"119","author":"J Shimazaki","year":"2012","unstructured":"Shimazaki J, Iseda A, Satake Y, Shimazaki-Den S (2012) Efficacy and safety of long-term corticosteroid eye drops after penetrating keratoplasty: a prospective, randomized, clinical trial. Ophthalmology 119:668\u2013673","journal-title":"Ophthalmology"},{"key":"1137_CR19","doi-asserted-by":"publisher","first-page":"927","DOI":"10.1097\/ICO.0000000000001239","volume":"36","author":"P Huang","year":"2017","unstructured":"Huang P, Tepelus T, Vickers LA, Baghdasaryan E, Huang J, Irvine JA et al (2017) Quantitative analysis of depth, distribution, and density of cysts in acanthamoeba keratitis using confocal microscopy. Cornea 36:927\u2013932","journal-title":"Cornea"},{"key":"1137_CR20","doi-asserted-by":"publisher","first-page":"862","DOI":"10.1111\/his.12237","volume":"63","author":"Y Sun","year":"2013","unstructured":"Sun Y, Hong J, Zhang P, Peng R, Xiao G (2013) Pathological characteristics of the different stages of acanthamoeba keratitis. Histopathology 63:862\u2013868","journal-title":"Histopathology"},{"key":"1137_CR21","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1051\/parasite\/2015010","volume":"22","author":"J Lorenzo-Morales","year":"2015","unstructured":"Lorenzo-Morales J, Khan NA, Walochnik J (2015) An update on acanthamoeba keratitis: diagnosis, pathogenesis and treatment. Parasite 22:10","journal-title":"Parasite"}],"container-title":["International Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10792-019-01137-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s10792-019-01137-1\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10792-019-01137-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,6,16]],"date-time":"2020-06-16T23:05:24Z","timestamp":1592348724000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s10792-019-01137-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,6,18]]},"references-count":21,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2019,12]]}},"alternative-id":["1137"],"URL":"https:\/\/doi.org\/10.1007\/s10792-019-01137-1","relation":{},"ISSN":["0165-5701","1573-2630"],"issn-type":[{"value":"0165-5701","type":"print"},{"value":"1573-2630","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,6,18]]},"assertion":[{"value":"17 May 2018","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 June 2019","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 June 2019","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"There is no conflict of interest to declare.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}