{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T18:52:54Z","timestamp":1791917574778,"version":"4.3.4"},"reference-count":24,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2019,8,20]],"date-time":"2019-08-20T00:00:00Z","timestamp":1566259200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2019,8,20]],"date-time":"2019-08-20T00:00:00Z","timestamp":1566259200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100002657","name":"Istanbul \u00dcniversitesi","doi-asserted-by":"publisher","award":["30783"],"award-info":[{"award-number":["30783"]}],"id":[{"id":"10.13039\/501100002657","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Int Ophthalmol"],"published-print":{"date-parts":[[2020,1]]},"DOI":"10.1007\/s10792-019-01157-x","type":"journal-article","created":{"date-parts":[[2019,8,20]],"date-time":"2019-08-20T18:02:45Z","timestamp":1566324165000},"page":"151-158","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Sleep disturbance and cognitive decline in multiple sclerosis patients with isolated optic neuritis as the first demyelinating event"],"prefix":"10.1007","volume":"40","author":[{"given":"Recai","family":"T\u00fcrko\u011flu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G\u00fcl\u00e7in","family":"Benbir","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Selen","family":"\u00d6zyurt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erdil","family":"Arsoy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ece","family":"Akbay\u0131r","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Selin","family":"Turan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Derya","family":"Karadeniz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vuslat","family":"Y\u0131lmaz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mehmet","family":"Gencer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4483-0394","authenticated-orcid":false,"given":"Erdem","family":"T\u00fcz\u00fcn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2019,8,20]]},"reference":[{"key":"1157_CR1","doi-asserted-by":"publisher","first-page":"428","DOI":"10.1111\/jsr.12490","volume":"26","author":"AJ Hughes","year":"2017","unstructured":"Hughes AJ, Parmenter BA, Haselkorn JK, Lovera JF, Bourdette D, Boudreau E, Cameron MH, Turner AP (2017) Sleep and its associations with perceived and objective cognitive impairment in individuals with multiple sclerosis. J Sleep Res 26:428\u2013435","journal-title":"J Sleep Res"},{"key":"1157_CR2","doi-asserted-by":"publisher","first-page":"1525","DOI":"10.5665\/sleep.6012","volume":"39","author":"TJ Braley","year":"2016","unstructured":"Braley TJ, Kratz AL, Kaplish N, Chervin RD (2016) Sleep and cognitive function in multiple sclerosis. Sleep 39:1525\u20131533","journal-title":"Sleep"},{"key":"1157_CR3","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1016\/j.sleep.2012.11.019","volume":"14","author":"JA Palma","year":"2013","unstructured":"Palma JA, Urrestarazu E, Iriarte J (2013) Sleep loss as risk factor for neurologic disorders: a review. Sleep Med 14:229\u2013236","journal-title":"Sleep Med"},{"key":"1157_CR4","doi-asserted-by":"publisher","first-page":"505","DOI":"10.1016\/S0306-4530(01)00071-3","volume":"27","author":"C Heesen","year":"2002","unstructured":"Heesen C, Gold SM, Raji A, Wiedemann K, Schulz KH (2002) Cognitive impairment correlates with hypothalamo-pituitary-adrenal axis dysregulation in multiple sclerosis. Psychoneuroendocrinology 27:505\u2013517","journal-title":"Psychoneuroendocrinology"},{"key":"1157_CR5","doi-asserted-by":"publisher","first-page":"323","DOI":"10.1080\/01616412.2016.1275460","volume":"39","author":"E Kantorov\u00e1","year":"2017","unstructured":"Kantorov\u00e1 E, Pol\u00e1\u010dek H, Bitt\u0161ansk\u00fd M, Baranovi\u010dov\u00e1 E, Hnilicov\u00e1 P, \u010cierny D, Siv\u00e1k \u0160, Nos\u00e1\u013e V, Zele\u0148\u00e1k K, Kur\u010da E (2017) Hypothalamic damage in multiple sclerosis correlates with disease activity, disability, depression, and fatigue. Neurol Res 39:323\u2013330","journal-title":"Neurol Res"},{"key":"1157_CR6","doi-asserted-by":"publisher","DOI":"10.1007\/s10072-019-3708-z","author":"M Gencer","year":"2019","unstructured":"Gencer M, Akbay\u0131r E, \u015een M, Arsoy E, Y\u0131lmaz V, Bulut N, T\u00fcz\u00fcn E, T\u00fcrko\u011flu R (2019) Serum orexin-A levels are associated with disease progression and motor impairment in multiple sclerosis. Neurol Sci. \nhttps:\/\/doi.org\/10.1007\/s10072-019-3708-z","journal-title":"Neurol Sci"},{"key":"1157_CR7","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1177\/135245850100700110","volume":"7","author":"KM Myhr","year":"2001","unstructured":"Myhr KM, Riise T, Vedeler C, Nortvedt MW, Gr\u00f8nning R, Midgard R, Nyland HI (2001) Disability and prognosis in multiple sclerosis: demographic and clinical variables important for the ability to walk and awarding of disability pension. Mult Scler J 7:59\u201365","journal-title":"Mult Scler J"},{"key":"1157_CR8","doi-asserted-by":"publisher","first-page":"473","DOI":"10.1212\/WNL.53.3.473","volume":"53","author":"TL S\u00f8rensen","year":"1999","unstructured":"S\u00f8rensen TL, Frederiksen JL, Br\u00f8nnum-Hansen H, Petersen HC (1999) Optic neuritis as onset manifestation of multiple sclerosis: a nationwide, long-term survey. Neurology 53:473\u2013478","journal-title":"Neurology"},{"key":"1157_CR9","doi-asserted-by":"publisher","first-page":"190","DOI":"10.1080\/08820139.2018.1528270","volume":"48","author":"B D\u00fczel","year":"2019","unstructured":"D\u00fczel B, Tamam Y, \u00c7oban A, T\u00fcz\u00fcn E (2019) Adipokines in multiple sclerosis patients with and without optic neuritis as the first clinical presentation. Immunol Invest 48:190\u2013197","journal-title":"Immunol Invest"},{"key":"1157_CR10","doi-asserted-by":"publisher","first-page":"292","DOI":"10.1002\/ana.22366","volume":"69","author":"CH Polman","year":"2011","unstructured":"Polman CH, Reingold SC, Banwell B et al (2011) Diagnostic criteria for multiple sclerosis: 2010 revisions to the McDonald criteria. Ann Neurol 69:292\u2013302","journal-title":"Ann Neurol"},{"key":"1157_CR11","doi-asserted-by":"publisher","first-page":"597","DOI":"10.5664\/jcsm.2172","volume":"8","author":"RB Berry","year":"2012","unstructured":"Berry RB, Budhiraja R, Gottlieb DJ et al (2012) Rules for scoring respiratory events in sleep: update of the 2007 AASM manual for the scoring of sleep and associated events. Deliberations of the sleep apnea definitions task force of the American Academy of Sleep Medicine. J Clin Sleep Med 8:597\u2013619","journal-title":"J Clin Sleep Med"},{"key":"1157_CR12","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1016\/S1389-9457(03)00010-8","volume":"4","author":"RP Allen","year":"2003","unstructured":"Allen RP, Picchietti D, Hening WA, Trenkwalder C, Walters AS, Montplaisi J (2003) Restless legs syndrome diagnosis and epidemiology workshop at the National Institutes of Health; International Restless Legs Syndrome Study Group. Restless legs syndrome: diagnostic criteria, special considerations, and epidemiology: a report from the restless legs syndrome diagnosis and epidemiology workshop at the National Institutes of Health. Sleep Med 4:101\u2013119","journal-title":"Sleep Med"},{"key":"1157_CR13","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1007\/s11940-019-0544-7","volume":"21","author":"GK Sakkas","year":"2019","unstructured":"Sakkas GK, Giannaki CD, Karatzaferi C, Manconi M (2019) Sleep abnormalities in multiple sclerosis. Curr Treat Options Neurol 21:4","journal-title":"Curr Treat Options Neurol"},{"key":"1157_CR14","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1016\/j.neulet.2010.02.062","volume":"474","author":"E Papu\u0107","year":"2010","unstructured":"Papu\u0107 E, Stelmasiak Z, Grieb P, Pawe\u0142 G, Rejdak K (2010) CSF hypocretin-1 concentrations correlate with the level of fatigue in multiple sclerosis patients. Neurosci Lett 474:9\u201312","journal-title":"Neurosci Lett"},{"key":"1157_CR15","doi-asserted-by":"publisher","first-page":"2071","DOI":"10.1007\/s00415-018-8949-x","volume":"265","author":"U Kallweit","year":"2018","unstructured":"Kallweit U, Bassetti CLA, Oberholzer M, Fronczek R, B\u00e9guin M, Strub M, Lammers GJ (2018) Coexisting narcolepsy (with and without cataplexy) and multiple sclerosis: six new cases and a literature review. J Neurol 265:2071\u20132078","journal-title":"J Neurol"},{"key":"1157_CR16","doi-asserted-by":"publisher","first-page":"885","DOI":"10.1007\/s00415-004-0442-z","volume":"251","author":"Y Oka","year":"2004","unstructured":"Oka Y, Kanbayashi T, Mezaki T, Iseki K, Matsubayashi J, Murakami G, Matsui M, Shimizu T, Shibasaki H (2004) Low CSF hypocretin-1\/orexin-A associated with hypersomnia secondary to hypothalamic lesion in a case of multiple sclerosis. J Neurol 251:885\u2013886","journal-title":"J Neurol"},{"key":"1157_CR17","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1080\/13854046.2016.1241894","volume":"31","author":"S Hansen","year":"2017","unstructured":"Hansen S, Muenssinger J, Kronhofmann S, Lautenbacher S, Oschmann P, Keune PM (2017) Cognitive screening in multiple sclerosis: the five-point test as a substitute for the PASAT in measuring executive function. Clin Neuropsychol 31:179\u2013192","journal-title":"Clin Neuropsychol"},{"key":"1157_CR18","doi-asserted-by":"publisher","first-page":"839","DOI":"10.2147\/CIA.S69270","volume":"10","author":"NV Ferreira","year":"2015","unstructured":"Ferreira NV, Cunha PJ, da Costa DI, dos Santos F, Costa FO, Consolim-Colombo F, Irigoyen MC (2015) Association between functional performance and executive cognitive functions in an elderly population including patients with low ankle-brachial index. Clin Interv Aging 10:839\u2013846","journal-title":"Clin Interv Aging"},{"key":"1157_CR19","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1111\/j.1600-0404.2006.00744.x","volume":"115","author":"T Saunam\u00e4ki","year":"2007","unstructured":"Saunam\u00e4ki T, Jehkonen M (2007) A review of executive functions in obstructive sleep apnea syndrome. Acta Neurol Scand 115:1\u201311","journal-title":"Acta Neurol Scand"},{"key":"1157_CR20","doi-asserted-by":"publisher","first-page":"176","DOI":"10.1016\/j.yebeh.2018.12.028","volume":"92","author":"K Chakravarty","year":"2019","unstructured":"Chakravarty K, Shukla G, Poornima S, Agarwal P, Gupta A, Mohammed A, Ray S, Pandey RM, Goyal V, Srivastava A, Behari M (2019) Effect of sleep quality on memory, executive function, and language performance in patients with refractory focal epilepsy and controlled epilepsy versus healthy controls\u2014a prospective study. Epilepsy Behav 92:176\u2013183","journal-title":"Epilepsy Behav"},{"key":"1157_CR21","doi-asserted-by":"publisher","first-page":"2677","DOI":"10.1210\/endo.142.6.8197","volume":"142","author":"A Kalsbeek","year":"2001","unstructured":"Kalsbeek A, Fliers E, Romijn JA, La Fleur SE, Wortel J, Bakker O, Endert E, Buijs RM (2001) The suprachiasmatic nucleus generates the diurnal changes in plasma leptin levels. Endocrinology 142:2677\u20132685","journal-title":"Endocrinology"},{"key":"1157_CR22","doi-asserted-by":"publisher","first-page":"619","DOI":"10.1093\/sleep\/27.4.619","volume":"27","author":"S Zhang","year":"2004","unstructured":"Zhang S, Zeitzer JM, Yoshida Y, Wisor JP, Nishino S, Edgar DM, Mignot E (2004) Lesions of the suprachiasmatic nucleus eliminate the daily rhythm of hypocretin-1 release. Sleep 27:619\u2013627","journal-title":"Sleep"},{"key":"1157_CR23","doi-asserted-by":"publisher","first-page":"5817","DOI":"10.3390\/ijms14035817","volume":"14","author":"R Hardeland","year":"2013","unstructured":"Hardeland R (2013) Chronobiology of melatonin beyond the feedback to the suprachiasmatic nucleus-consequences to melatonin dysfunction. Int J Mol Sci 14:5817\u20135841","journal-title":"Int J Mol Sci"},{"key":"1157_CR24","doi-asserted-by":"publisher","first-page":"e12525","DOI":"10.1111\/jpi.12525","volume":"65","author":"R Hardeland","year":"2018","unstructured":"Hardeland R (2018) Melatonin and inflammation\u2014story of a double-edged blade. J Pineal Res 65:e12525","journal-title":"J Pineal Res"}],"container-title":["International Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10792-019-01157-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s10792-019-01157-x\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10792-019-01157-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,8,18]],"date-time":"2020-08-18T23:38:31Z","timestamp":1597793911000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s10792-019-01157-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,8,20]]},"references-count":24,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2020,1]]}},"alternative-id":["1157"],"URL":"https:\/\/doi.org\/10.1007\/s10792-019-01157-x","relation":{},"ISSN":["0165-5701","1573-2630"],"issn-type":[{"value":"0165-5701","type":"print"},{"value":"1573-2630","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,8,20]]},"assertion":[{"value":"10 April 2019","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 August 2019","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 August 2019","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and\/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"This article does not contain any studies with animals performed by any of the authors.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Human and animal rights"}},{"value":"Informed consent was obtained from all individual participants included in the study.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}}]}}