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Piast\u00f3w \u015al\u0105skich we Wroc\u0142awiu","award":["STM.C240.17.037"],"award-info":[{"award-number":["STM.C240.17.037"]}]},{"DOI":"10.13039\/100007819","name":"Allergan","doi-asserted-by":"publisher","award":["PG-2018-10478"],"award-info":[{"award-number":["PG-2018-10478"]}],"id":[{"id":"10.13039\/100007819","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Int Ophthalmol"],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n<jats:sec>\n<jats:title>Purpose<\/jats:title>\n<jats:p>To evaluate the efficacy of postoperative management with 5-fluorouracil injections after XEN Gel Stent implantation.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Methods<\/jats:title>\n<jats:p>Prospective real-world evidence study included 39 eyes (of 36 patients) with primary open-angle glaucoma without previous glaucoma surgery and with uncontrolled intraocular pressure (IOP), glaucoma progression, or intolerance to IOP-lowering therapy. Patients underwent mitomycin C-augmented XEN implantation either as a stand-alone procedure or combined with cataract extraction. 5-Fluorouracil subconjunctival injections were a first-choice therapy for bleb failure and were administered according to predetermined criteria (analogous to pro re nata regimen in age-related macular degeneration treatment). Primary outcome was unqualified success, defined as postoperative IOP\u2009&lt;\u200918\u00a0mmHg and &gt;\u200920% reduction from medicated baseline without any antiglaucoma medications and no detected glaucoma progression.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Results<\/jats:title>\n<jats:p>At median follow-up of 8\u00a0months (range 3\u201324\u00a0months), IOP decreased from a medicated baseline value of 23\u00a0mmHg (95% CI 21\u201324\u00a0mmHg) to 13\u00a0mmHg (95% CI 12\u201315\u00a0mmHg) and number of medications decreased from 3 (95% CI 2\u20133) to 0 (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.0001 for both). Median number of 5-fluorouracil injections per eye was 3 (95% CI 2\u20133), and median time to first injection was 0.5\u00a0months (95% CI 0.25\u20133\u00a0months) after surgery. Thirteen eyes (33.3%) underwent \u2265\u20091 needling, and surgical revision was performed in three cases (7.7%). The primary outcome measure, which allows performing additional procedures, was achieved in 27 eyes (69%).<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Conclusions<\/jats:title>\n<jats:p>5-Fluorouracil subconjunctival injections are safe and effective in postoperative management of bleb failure after XEN implantation and represent a viable alternative to other methods.<\/jats:p>\n<\/jats:sec>","DOI":"10.1007\/s10792-019-01168-8","type":"journal-article","created":{"date-parts":[[2019,10,2]],"date-time":"2019-10-02T15:04:07Z","timestamp":1570028647000},"page":"235-246","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Efficacy of postoperative management with 5-fluorouracil injections after XEN Gel Stent implantation"],"prefix":"10.1007","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9103-2141","authenticated-orcid":false,"given":"Ewa","family":"Wa\u0142ek","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1099-4876","authenticated-orcid":false,"given":"Joanna","family":"Prze\u017adziecka-Do\u0142yk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iwona","family":"Helemejko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4020-3203","authenticated-orcid":false,"given":"Marta","family":"Misiuk-Hoj\u0142o","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2019,10,1]]},"reference":[{"key":"1168_CR1","doi-asserted-by":"publisher","first-page":"1301","DOI":"10.1016\/j.jcrs.2014.01.032","volume":"40","author":"RA Lewis","year":"2014","unstructured":"Lewis RA (2014) Ab interno approach to the subconjunctival space using a collagen glaucoma stent. 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