{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,30]],"date-time":"2025-08-30T16:51:26Z","timestamp":1756572686910,"version":"3.37.3"},"reference-count":21,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2019,10,19]],"date-time":"2019-10-19T00:00:00Z","timestamp":1571443200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2019,10,19]],"date-time":"2019-10-19T00:00:00Z","timestamp":1571443200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100003453","name":"Natural Science Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2014A030310213"],"award-info":[{"award-number":["2014A030310213"]}],"id":[{"id":"10.13039\/501100003453","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Int Ophthalmol"],"published-print":{"date-parts":[[2020,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>Distribution of intermediate filament (IF) proteins in normal extraocular muscles (EOMs) showed that the EOMs differ significantly from the other muscles in the body with respect to their IFs composition, including desmin and nestin. The aim of the present study was to investigate the pathological changes in the medial rectus (MR) in patients with concomitant exotropia (XT).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Forty-six MR muscle samples from 46 patients with XT were analyzed pathologically and processed for immunohistochemistry with specific antibodies against desmin and nestin.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Although most of MR muscles remained normal structures relatively, they presented high expression of desmin, and in contrast, nestin was absent in a large proportion of the MR muscles.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Desmin, which is downregulated in normal EOMs, had high expression in MR muscles of patients with XT. Nestin, which is present in a high proportion of normal EOMs, was downregulated in MR muscles of patients with XT.<\/jats:p><\/jats:sec>","DOI":"10.1007\/s10792-019-01197-3","type":"journal-article","created":{"date-parts":[[2019,10,19]],"date-time":"2019-10-19T15:39:07Z","timestamp":1571499547000},"page":"403-410","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Intermediate filaments in the medial rectus muscles in patients with concomitant exotropia"],"prefix":"10.1007","volume":"40","author":[{"given":"Tao","family":"Shen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing","family":"Lin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiuling","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0639-1543","authenticated-orcid":false,"given":"Daming","family":"Deng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2019,10,19]]},"reference":[{"issue":"4","key":"1197_CR1","doi-asserted-by":"publisher","first-page":"409","DOI":"10.1136\/bjo.2004.053678","volume":"89","author":"A Arora","year":"2005","unstructured":"Arora A, Williams B, Arora AK, McNamara R, Yates J, Fielder A (2005) Decreasing strabismus surgery. Br J Ophthalmol 89(4):409\u2013412. https:\/\/doi.org\/10.1136\/bjo.2004.053678","journal-title":"Br J Ophthalmol"},{"issue":"1","key":"1197_CR2","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1016\/j.jaapos.2013.10.019","volume":"18","author":"R Rabinowitz","year":"2014","unstructured":"Rabinowitz R, Demer JL (2014) Muscle path length in horizontal strabismus. J AAPOS 18(1):4\u20139. https:\/\/doi.org\/10.1016\/j.jaapos.2013.10.019","journal-title":"J AAPOS"},{"issue":"4","key":"1197_CR3","doi-asserted-by":"publisher","first-page":"1419","DOI":"10.1167\/iovs.02-0638","volume":"44","author":"D Kjellgren","year":"2003","unstructured":"Kjellgren D, Thornell LE, Andersen J, Pedrosa-Domellof F (2003) Myosin heavy chain isoforms in human extraocular muscles. Invest Ophthalmol Vis Sci 44(4):1419\u20131425","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"7","key":"1197_CR4","first-page":"1608","volume":"41","author":"F Pedrosa-Domellof","year":"2000","unstructured":"Pedrosa-Domellof F, Holmgren Y, Lucas CA, Hoh JF, Thornell LE (2000) Human extraocular muscles: unique pattern of myosin heavy chain expression during myotube formation. Invest Ophthalmol Vis Sci 41(7):1608\u20131616","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"12","key":"1197_CR5","doi-asserted-by":"publisher","first-page":"4233","DOI":"10.1167\/iovs.04-0456","volume":"45","author":"D Kjellgren","year":"2004","unstructured":"Kjellgren D, Thornell LE, Virtanen I, Pedrosa-Domellof F (2004) Laminin isoforms in human extraocular muscles. Invest Ophthalmol Vis Sci 45(12):4233\u20134239. https:\/\/doi.org\/10.1167\/iovs.04-0456","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"7","key":"1197_CR6","doi-asserted-by":"publisher","first-page":"3226","DOI":"10.1167\/iovs.08-3333","volume":"50","author":"JX Liu","year":"2009","unstructured":"Liu JX, Willison HJ, Pedrosa-Domellof F (2009) Immunolocalization of GQ1b and related gangliosides in human extraocular neuromuscular junctions and muscle spindles. Invest Ophthalmol Vis Sci 50(7):3226\u20133232. https:\/\/doi.org\/10.1167\/iovs.08-3333","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"1","key":"1197_CR7","doi-asserted-by":"publisher","first-page":"217","DOI":"10.3892\/mmr.2012.1149","volume":"7","author":"Y Zhu","year":"2013","unstructured":"Zhu Y, Deng D, Long C, Jin G, Zhang Q, Shen H (2013) Abnormal expression of seven myogenesis-related genes in extraocular muscles of patients with concomitant strabismus. Mol Med Rep 7(1):217\u2013222. https:\/\/doi.org\/10.3892\/mmr.2012.1149","journal-title":"Mol Med Rep"},{"issue":"8","key":"1197_CR8","doi-asserted-by":"publisher","first-page":"5151","DOI":"10.1167\/iovs.14-14316","volume":"55","author":"AH Janbaz","year":"2014","unstructured":"Janbaz AH, Lindstrom M, Liu JX, Pedrosa Domellof F (2014) Intermediate filaments in the human extraocular muscles. Invest Ophthalmol Vis Sci 55(8):5151\u20135159. https:\/\/doi.org\/10.1167\/iovs.14-14316","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"9","key":"1197_CR9","doi-asserted-by":"publisher","first-page":"3856","DOI":"10.1167\/iovs.03-0160","volume":"44","author":"JL Demer","year":"2003","unstructured":"Demer JL, Oh SY, Clark RA, Poukens V (2003) Evidence for a pulley of the inferior oblique muscle. Invest Ophthalmol Vis Sci 44(9):3856\u20133865","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"6","key":"1197_CR10","first-page":"1125","volume":"36","author":"JL Demer","year":"1995","unstructured":"Demer JL, Miller JM, Poukens V, Vinters HV, Glasgow BJ (1995) Evidence for fibromuscular pulleys of the recti extraocular muscles. Invest Ophthalmol Vis Sci 36(6):1125\u20131136","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"6","key":"1197_CR11","first-page":"373","volume":"100","author":"M Gralek","year":"1998","unstructured":"Gralek M, Krawczyk T (1998) Pathomorphological evaluation of the extraocular muscles during strabismus. Klin Oczna 100(6):373\u2013375","journal-title":"Klin Oczna"},{"issue":"8","key":"1197_CR12","doi-asserted-by":"publisher","first-page":"1076","DOI":"10.1038\/eye.2008.133","volume":"22","author":"SH Kim","year":"2008","unstructured":"Kim SH, Cho YA, Park CH, Uhm CS (2008) The ultrastructural changes of tendon axonal profiles of medial rectus muscles according to duration in patients with intermittent exotropia. Eye 22(8):1076\u20131081. https:\/\/doi.org\/10.1038\/eye.2008.133","journal-title":"Eye"},{"issue":"5","key":"1197_CR13","doi-asserted-by":"publisher","first-page":"827","DOI":"10.1083\/jcb.124.5.827","volume":"124","author":"H Li","year":"1994","unstructured":"Li H, Choudhary SK, Milner DJ, Munir MI, Kuisk IR, Capetanaki Y (1994) Inhibition of desmin expression blocks myoblast fusion and interferes with the myogenic regulators MyoD and myogenin. J Cell Biol 124(5):827\u2013841","journal-title":"J Cell Biol"},{"issue":"2","key":"1197_CR14","doi-asserted-by":"publisher","first-page":"422","DOI":"10.1006\/dbio.1995.8070","volume":"172","author":"G Weitzer","year":"1995","unstructured":"Weitzer G, Milner DJ, Kim JU, Bradley A, Capetanaki Y (1995) Cytoskeletal control of myogenesis: a desmin null mutation blocks the myogenic pathway during embryonic stem cell differentiation. Dev Biol 172(2):422\u2013439. https:\/\/doi.org\/10.1006\/dbio.1995.8070","journal-title":"Dev Biol"},{"issue":"6","key":"1197_CR15","doi-asserted-by":"publisher","first-page":"1283","DOI":"10.1083\/jcb.150.6.1283","volume":"150","author":"DJ Milner","year":"2000","unstructured":"Milner DJ, Mavroidis M, Weisleder N, Capetanaki Y (2000) Desmin cytoskeleton linked to muscle mitochondrial distribution and respiratory function. J Cell Biol 150(6):1283\u20131298","journal-title":"J Cell Biol"},{"issue":"1","key":"1197_CR16","doi-asserted-by":"publisher","first-page":"216","DOI":"10.1006\/dbio.1994.1248","volume":"165","author":"AM Kachinsky","year":"1994","unstructured":"Kachinsky AM, Dominov JA, Miller JB (1994) Myogenesis and the intermediate filament protein, nestin. Dev Biol 165(1):216\u2013228. https:\/\/doi.org\/10.1006\/dbio.1994.1248","journal-title":"Dev Biol"},{"key":"1197_CR17","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1016\/S0074-7696(08)62030-6","volume":"134","author":"K Albers","year":"1992","unstructured":"Albers K, Fuchs E (1992) The molecular biology of intermediate filament proteins. Int Rev Cytol 134:243\u2013279","journal-title":"Int Rev Cytol"},{"issue":"Pt 4","key":"1197_CR18","doi-asserted-by":"crossref","first-page":"1291","DOI":"10.1242\/jcs.106.4.1291","volume":"106","author":"T Sejersen","year":"1993","unstructured":"Sejersen T, Lendahl U (1993) Transient expression of the intermediate filament nestin during skeletal muscle development. J Cell Sci 106(Pt 4):1291\u20131300","journal-title":"J Cell Sci"},{"issue":"43","key":"1197_CR19","doi-asserted-by":"publisher","first-page":"7267","DOI":"10.1038\/sj.onc.1207946","volume":"23","author":"SK Singh","year":"2004","unstructured":"Singh SK, Clarke ID, Hide T, Dirks PB (2004) Cancer stem cells in nervous system tumors. Oncogene 23(43):7267\u20137273. https:\/\/doi.org\/10.1038\/sj.onc.1207946","journal-title":"Oncogene"},{"issue":"4","key":"1197_CR20","doi-asserted-by":"publisher","first-page":"862","DOI":"10.1378\/chest.10-1121","volume":"139","author":"S Ryuge","year":"2011","unstructured":"Ryuge S, Sato Y, Wang GQ, Matsumoto T, Jiang SX, Katono K, Inoue H, Satoh Y, Masuda N (2011) Prognostic significance of nestin expression in resected non-small cell lung cancer. Chest 139(4):862\u2013869. https:\/\/doi.org\/10.1378\/chest.10-1121","journal-title":"Chest"},{"issue":"5","key":"1197_CR21","doi-asserted-by":"publisher","first-page":"587","DOI":"10.1038\/eye.2014.29","volume":"28","author":"A Awadein","year":"2014","unstructured":"Awadein A, Eltanamly RM, Elshazly M (2014) Intermittent exotropia: relation between age and surgical outcome: a change-point analysis. Eye 28(5):587\u2013593. https:\/\/doi.org\/10.1038\/eye.2014.29","journal-title":"Eye"}],"container-title":["International Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10792-019-01197-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s10792-019-01197-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10792-019-01197-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,10,2]],"date-time":"2022-10-02T05:14:07Z","timestamp":1664687647000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s10792-019-01197-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,10,19]]},"references-count":21,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2020,2]]}},"alternative-id":["1197"],"URL":"https:\/\/doi.org\/10.1007\/s10792-019-01197-3","relation":{},"ISSN":["0165-5701","1573-2630"],"issn-type":[{"type":"print","value":"0165-5701"},{"type":"electronic","value":"1573-2630"}],"subject":[],"published":{"date-parts":[[2019,10,19]]},"assertion":[{"value":"9 April 2019","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 October 2019","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 October 2019","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"All authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and\/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"Informed consent was obtained from all individual participants included in the study.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}}]}}