{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T12:56:54Z","timestamp":1790081814678,"version":"4.0.1"},"reference-count":37,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2019,11,23]],"date-time":"2019-11-23T00:00:00Z","timestamp":1574467200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2019,11,23]],"date-time":"2019-11-23T00:00:00Z","timestamp":1574467200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Int Ophthalmol"],"published-print":{"date-parts":[[2020,3]]},"DOI":"10.1007\/s10792-019-01227-0","type":"journal-article","created":{"date-parts":[[2019,11,23]],"date-time":"2019-11-23T17:02:57Z","timestamp":1574528577000},"page":"667-675","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Ophthalmic features and management outcomes of 30 children having Goldenhar syndrome"],"prefix":"10.1007","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2846-0597","authenticated-orcid":false,"given":"Manpreet","family":"Singh","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manpreet","family":"Kaur","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aditi Mehta","family":"Grewal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sonam","family":"Yangzes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deepti","family":"Yadav","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zoramthara","family":"Zadeng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pankaj","family":"Gupta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2019,11,23]]},"reference":[{"key":"1227_CR1","first-page":"243","volume":"1","author":"M Goldenhar","year":"1952","unstructured":"Goldenhar M (1952) Associations malformatives de l\u2019oeil et l\u2019oreille, en particulier le syndrome dermoide \u00e9pibulbaire-appendices auriculaires-fistula auris congenita et ses relations avec la dysostose mandibulo-faciale. J Genet Hum 1:243\u2013282","journal-title":"J Genet Hum"},{"key":"1227_CR2","doi-asserted-by":"publisher","first-page":"991","DOI":"10.1016\/S0022-3476(63)80233-4","volume":"63","author":"RJ Gorlin","year":"1963","unstructured":"Gorlin RJ, Jue KL, Jacobsen U, Goldschmidt E (1963) Oculoauriculovertebral dysplasia. J Pediatr 63:991\u2013999","journal-title":"J Pediatr"},{"key":"1227_CR3","first-page":"276","volume":"26","author":"MM Cohen Jr","year":"1989","unstructured":"Cohen MM Jr, Rollnick BR, Kaye CI (1989) Oculoauriculovertebral spectrum: an updated critique. Cleft Palate J 26:276\u2013286","journal-title":"Cleft Palate J"},{"key":"1227_CR4","first-page":"707","volume-title":"Syndromes of the head and neck","author":"RJ Gorlin","year":"1990","unstructured":"Gorlin RJ, Cohen MM, Levin LS (1990) Syndromes of the head and neck. Oxford University Press, New York, pp 707\u2013708"},{"key":"1227_CR5","doi-asserted-by":"publisher","first-page":"250","DOI":"10.1016\/0002-9394(73)91020-9","volume":"75","author":"JL Baum","year":"1973","unstructured":"Baum JL, Feingold M (1973) Ocular aspects of Goldenhar\u2019s syndrome. Am J Ophthalmol 75:250\u2013257","journal-title":"Am J Ophthalmol"},{"key":"1227_CR6","first-page":"147","volume":"30","author":"VA Rao","year":"1982","unstructured":"Rao VA, Rao S, Lamba PA (1982) Goldenhar\u2019s syndrome (an analysis of 10 cases and aetiological considerations). Indian J Ophthalmol 30:147\u2013149","journal-title":"Indian J Ophthalmol"},{"key":"1227_CR7","doi-asserted-by":"publisher","first-page":"555","DOI":"10.1016\/0002-9394(85)90681-6","volume":"100","author":"AM Mansour","year":"1985","unstructured":"Mansour AM, Wang F, Henkind P, Goldberg R, Shprintzen R (1985) Ocular findings in the facioauriculovertebral sequence (Goldenhar-Gorlin syndrome). Am J Ophthalmol 100:555\u2013559","journal-title":"Am J Ophthalmol"},{"key":"1227_CR8","doi-asserted-by":"publisher","first-page":"339","DOI":"10.1016\/0039-6257(89)90011-8","volume":"33","author":"AM Mansour","year":"1989","unstructured":"Mansour AM, Barber JC, Reinecke RD, Wang FM (1989) Ocular choristomas. Surv Ophthalmol 33:339\u2013358","journal-title":"Surv Ophthalmol"},{"key":"1227_CR9","doi-asserted-by":"publisher","first-page":"1529","DOI":"10.1016\/j.ophtha.2013.01.015","volume":"120","author":"JJ Khong","year":"2013","unstructured":"Khong JJ, Hardy TG, McNab AA (2013) Prevalence of Oculo-auriculo-vertebral Spectrum in Dermolipoma. Ophthalmology 120:1529\u20131532","journal-title":"Ophthalmology"},{"key":"1227_CR10","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1097\/IOP.0000000000000347","volume":"31","author":"HA Tawfik","year":"2015","unstructured":"Tawfik HA, Abdulhafez MH, Fouad YA (2015) Congenital upper eyelid coloboma: embryologic, nomenclatorial, nosologic, etiologic, pathogenetic, epidemiologic, clinical, and management perspectives. Ophthal Plast Reconstr Surg 31:1\u201312","journal-title":"Ophthal Plast Reconstr Surg"},{"key":"1227_CR11","doi-asserted-by":"publisher","first-page":"96","DOI":"10.22336\/rjo.2018.15","volume":"62","author":"S Schmitzer","year":"2018","unstructured":"Schmitzer S, Burcel M, D\u0103sc\u0103lescu D, Popteanu IC (2018) Goldenhar Syndrome -ophthalmologist\u2019s perspective. Rom J Ophthalmol 62:96\u2013104","journal-title":"Rom J Ophthalmol"},{"key":"1227_CR12","doi-asserted-by":"publisher","first-page":"151","DOI":"10.3928\/01913913-20090505-06","volume":"46","author":"AK Grover","year":"2009","unstructured":"Grover AK, Chaudhuri Z, Malik S, Bageja S, Menon V (2009) Congenital eyelid colobomas in 51 patients. J Pediatr Ophthalmol Strabismus 46:151\u2013159","journal-title":"J Pediatr Ophthalmol Strabismus"},{"key":"1227_CR13","doi-asserted-by":"publisher","first-page":"313","DOI":"10.1111\/j.1442-9071.1986.tb00465.x","volume":"14","author":"JR Collin","year":"1986","unstructured":"Collin JR (1986) Congenital upper lid coloboma. Aust N Z J Ophthalmol 14:313\u2013317","journal-title":"Aust N Z J Ophthalmol"},{"key":"1227_CR14","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1067\/mpa.2002.124651","volume":"6","author":"P Watts","year":"2002","unstructured":"Watts P, Michaeli-Cohen A, Abdolell M, Rootman D (2002) Outcome of lamellar keratoplasty for limbal dermoids in children. J AAPOS 6:209\u2013215","journal-title":"J AAPOS"},{"key":"1227_CR15","doi-asserted-by":"publisher","first-page":"114","DOI":"10.3928\/01913913-20110823-01","volume":"49","author":"A Pirouzian","year":"2012","unstructured":"Pirouzian A, Holz H, Merrill K, Sudesh R, Karlen K (2012) Surgical management of pediatric limbal dermoids with sutureless amniotic membrane transplantation and augmentation. J Pediatr Ophthalmol Strabismus 49:114\u2013149","journal-title":"J Pediatr Ophthalmol Strabismus"},{"key":"1227_CR16","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1097\/EJA.0000000000000556","volume":"34","author":"F Hasham","year":"2017","unstructured":"Hasham F, van Helmond N, Sidlow R (2017) Anaesthesia and orphan disease: difficult ventilation following intubation in Goldenhar syndrome. Eur J Anaesthesiol 34:181\u2013183","journal-title":"Eur J Anaesthesiol"},{"key":"1227_CR17","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1097\/SCS.0000000000000387","volume":"25","author":"K Bogusiak","year":"2014","unstructured":"Bogusiak K, Arkuszewski P, Skorek-Stachnik K, Kozakiewicz M (2014) Treatment strategy in Goldenhar syndrome. J Craniofac Surg 25:177\u2013183","journal-title":"J Craniofac Surg"},{"key":"1227_CR18","doi-asserted-by":"publisher","first-page":"1208","DOI":"10.1002\/ajmg.a.38151","volume":"173","author":"N Cohen","year":"2017","unstructured":"Cohen N, Cohen E, Gaiero A, Zecca S, Fichera G, Baldi F, Giordanetto JF, Mercier JM, Cohen A (2017) Maxillofacial features and systemic malformations in expanded spectrum Hemifacial Microsomia. Am J Med Genet A 173:1208\u20131218","journal-title":"Am J Med Genet A"},{"key":"1227_CR19","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1097\/MCD.0b013e328010d313","volume":"16","author":"C Tasse","year":"2007","unstructured":"Tasse C, Majewski F, B\u00f6hringer S, Fischer S, L\u00fcdecke HJ, Gillessen-Kaesbach G, Wieczorek D (2007) A family with autosomal dominant oculo-auriculo-vertebral spectrum. Clin Dysmorphol 16:1\u20137","journal-title":"Clin Dysmorphol"},{"key":"1227_CR20","doi-asserted-by":"publisher","first-page":"93","DOI":"10.2147\/TACG.S12643","volume":"4","author":"C Farra","year":"2011","unstructured":"Farra C, Yunis K, Yazbeck N, Majdalani M, Charafeddine L, Wakim R, Awwad J (2011) A Lebanese family with autosomal recessive oculo-auriculo-vertebral (OAV) spectrum and review of the literature: is OAV a genetically heterogeneous disorder? Appl Clin Genet 4:93\u201397","journal-title":"Appl Clin Genet"},{"key":"1227_CR21","doi-asserted-by":"publisher","first-page":"112","DOI":"10.1016\/S0022-3476(86)80783-1","volume":"108","author":"HC Soltan","year":"1986","unstructured":"Soltan HC, Holmes LB (1986) Familial occurrence of malformations possibly attributable to vascular abnormalities. J Pediatr 108:112\u2013114","journal-title":"J Pediatr"},{"key":"1227_CR22","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1111\/j.1601-6343.2007.00391.x","volume":"10","author":"JK Hartsfield","year":"2007","unstructured":"Hartsfield JK (2007) Review of etiologic heterogeneity of the oculo-auriculo-vertebral spectrum (Hemifacial Microsomia). Orthod Craniofac Res 10:121\u2013128","journal-title":"Orthod Craniofac Res"},{"key":"1227_CR23","doi-asserted-by":"crossref","unstructured":"Str\u00f6mland K, Miller M, Sj\u00f6green L, Johansson M, Joelsson BM, Billstedt E, Gillberg C, Danielsson S, Jacobsson C, Andersson-Norinder J, Granstr\u00f6m G (2007) Oculo-auriculo-vertebral spectrum: associated anomalies, functional deficits and possible developmental risk factors. Am J Med Genet A 143A: 1317\u20131325","DOI":"10.1002\/ajmg.a.31769"},{"key":"1227_CR24","doi-asserted-by":"publisher","first-page":"187","DOI":"10.3928\/0191-3913-20070301-15","volume":"44","author":"Z Chaudhuri","year":"2007","unstructured":"Chaudhuri Z, Grover AK, Bageja S, Jha SN, Mohan S (2007) Morning Glory Anomaly With Bilateral Choroidal Colobomas in a Patient With Goldenhar\u2019s Syndrome. J Pediatr Ophthalmol Strabismus 44:187\u2013189","journal-title":"J Pediatr Ophthalmol Strabismus"},{"key":"1227_CR25","doi-asserted-by":"publisher","first-page":"1327","DOI":"10.1016\/S0161-6420(84)34147-1","volume":"91","author":"S Margolis","year":"1984","unstructured":"Margolis S, Aleksic S, Charles N, McCarthy J, Greco A, Budzilovich G (1984) Retinal and optic nerve findings in Goldenhar-Gorlin syndrome. Ophthalmology 91:1327\u20131333","journal-title":"Ophthalmology"},{"key":"1227_CR26","doi-asserted-by":"publisher","first-page":"377","DOI":"10.1093\/tropej\/fmi020","volume":"51","author":"S Bayraktar","year":"2005","unstructured":"Bayraktar S, Bayraktar ST, Ataoglu E, Ayaz A, Elevli M (2005) Goldenhar\u2019s syndrome associated with multiple congenital anomalies. J Trop Paediatr 51:377\u2013379","journal-title":"J Trop Paediatr"},{"key":"1227_CR27","doi-asserted-by":"publisher","first-page":"297","DOI":"10.1007\/BF02426976","volume":"2","author":"ME Pierpont","year":"1982","unstructured":"Pierpont ME, Moller JH, Gorlin RJ, Edwards JE (1982) Congenital cardiac, pulmonary and vascular malformations in oculoauriculovertebral dysplasia. Pediatr Cardiol 2:297\u2013302","journal-title":"Pediatr Cardiol"},{"key":"1227_CR28","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1136\/bjo.55.3.145","volume":"55","author":"DI Bowen","year":"1971","unstructured":"Bowen DI, Collum LM, Rees DO (1971) Clinical aspects of oculo-auriculo-vertebral dysplasia. Br J Ophthalmol 55:145\u2013154","journal-title":"Br J Ophthalmol"},{"key":"1227_CR29","first-page":"17","volume":"316","author":"S Bhallil","year":"2010","unstructured":"Bhallil S, Benatiya I, El Abdouni O, Mahjoubi B (2010) Hicham T (2010) Goldenhar syndrome: ocular features. Bull Soc Belge Ophtalmol 316:17\u201319","journal-title":"Bull Soc Belge Ophtalmol"},{"key":"1227_CR30","doi-asserted-by":"publisher","first-page":"1001","DOI":"10.1016\/0002-9394(75)90685-6","volume":"79","author":"FJ Elsas","year":"1975","unstructured":"Elsas FJ, Green WR (1975) Epibulbar tumors in childhood. Am J Ophthalmol 79:1001\u20131007","journal-title":"Am J Ophthalmol"},{"key":"1227_CR31","doi-asserted-by":"publisher","first-page":"397","DOI":"10.1016\/j.ejmg.2005.04.015","volume":"48","author":"C Tasse","year":"2005","unstructured":"Tasse C, B\u00f6hringer S, Fischer S, L\u00fcdecke HJ, Albrecht B, Horn D, Janecke A, Kling R, K\u00f6nig R, Lorenz B, Majewski F, Maeyens E, Meinecke P, Mitulla B, Mohr C, Preischl M, Umstadt H, Kohlhase J, Gillessen-Kaesbach G, Wieczorek D (2005) Oculo-auriculo-vertebral spectrum (OAVS): clinical evaluation and severity scoring of 53 patients and proposal for a new classification. Eur J Med Genet 48:397\u2013411","journal-title":"Eur J Med Genet"},{"key":"1227_CR32","doi-asserted-by":"publisher","first-page":"361","DOI":"10.1002\/ajmg.1320260215","volume":"26","author":"BR Rollnick","year":"1987","unstructured":"Rollnick BR, Kaye CI, Nagatoshi K, Hauck W, Martin AO (1987) Oculoauriculovertebral dysplasia and variants: phenotypic characteristics of 294 patients. Am J Med Genet 26:361\u2013375","journal-title":"Am J Med Genet"},{"key":"1227_CR33","first-page":"277","volume":"18","author":"O Engiz","year":"2007","unstructured":"Engiz O, Balci S, Unsal M, Ozer S, Ozug KK, Aktas D (2007) 31 cases with oculoauriculovertebral dysplasia (Goldenhar syndrome): clinical, neuroradiologic, audiologic and cytogenetic findings. Genet Couns 18:277\u2013288","journal-title":"Genet Couns"},{"key":"1227_CR34","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1002\/uog.1118","volume":"24","author":"P Martinelli","year":"2004","unstructured":"Martinelli P, Maruotti G, Agangi A, Mazzarelli LL, Bifulco G, Paladini D (2004) Prenatal diagnosis of hemifacial microsomia and ipsilateral cerebellar hypoplasia in a fetus with oculoauriculovertebral spectrum. Ultrasound Obstet Gynecol 24:199\u2013201","journal-title":"Ultrasound Obstet Gynecol"},{"key":"1227_CR35","doi-asserted-by":"publisher","first-page":"944","DOI":"10.3174\/ajnr.A2892","volume":"33","author":"AA Abdel Razek","year":"2012","unstructured":"Abdel Razek AA, Elkhamary S, Al-Mesfer S, Alkatan HM (2012) Correlation of apparent diffusion coefficient at 3T with prognostic parameters of retinoblastoma. AJNR Am J Neuroradiol 33:944\u2013948","journal-title":"AJNR Am J Neuroradiol"},{"key":"1227_CR36","doi-asserted-by":"publisher","first-page":"775","DOI":"10.1259\/bjr\/32022497","volume":"84","author":"AA Razek","year":"2011","unstructured":"Razek AA, Elkhamary S (2011) MRI of retinoblastoma. Br J Radiol 84:775\u2013784","journal-title":"Br J Radiol"},{"key":"1227_CR37","doi-asserted-by":"publisher","first-page":"137","DOI":"10.4103\/2249-4847.179938","volume":"5","author":"M Kaur","year":"2016","unstructured":"Kaur M, Singh S, Singh M (2016) Congenital bilateral eyelid imbrication in a neonate: a rare case. J Clin Neonatol 5:137\u2013139","journal-title":"J Clin Neonatol"}],"container-title":["International Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10792-019-01227-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s10792-019-01227-0\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10792-019-01227-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,11,22]],"date-time":"2020-11-22T00:05:19Z","timestamp":1606003519000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s10792-019-01227-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,11,23]]},"references-count":37,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2020,3]]}},"alternative-id":["1227"],"URL":"https:\/\/doi.org\/10.1007\/s10792-019-01227-0","relation":{},"ISSN":["0165-5701","1573-2630"],"issn-type":[{"value":"0165-5701","type":"print"},{"value":"1573-2630","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,11,23]]},"assertion":[{"value":"29 June 2019","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 November 2019","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 November 2019","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"All authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"All procedures performed in studies involving human participants were in accordance with the ethical standards of the Post Graduate Institute of Medical Education and Research, Chandigarh, India, and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"An informed consent was obtained from all individual participants included in the study.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}}]}}