{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,9]],"date-time":"2026-08-09T03:50:47Z","timestamp":1786247447619,"version":"build-2736575974"},"reference-count":28,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2020,2,17]],"date-time":"2020-02-17T00:00:00Z","timestamp":1581897600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2020,2,17]],"date-time":"2020-02-17T00:00:00Z","timestamp":1581897600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["HO 3277\/2-1"],"award-info":[{"award-number":["HO 3277\/2-1"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Int Ophthalmol"],"published-print":{"date-parts":[[2020,6]]},"DOI":"10.1007\/s10792-020-01306-7","type":"journal-article","created":{"date-parts":[[2020,2,17]],"date-time":"2020-02-17T08:05:35Z","timestamp":1581926735000},"page":"1403-1410","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["The impact of intraocular pressure fluctuations and other factors on conversion of ocular hypertension to primary open-angle glaucoma"],"prefix":"10.1007","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7989-9420","authenticated-orcid":false,"given":"Susanne","family":"Hopf","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Doris","family":"Schwantuschke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norbert","family":"Pfeiffer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jochem","family":"Koenig","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katharina","family":"Bell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esther Maria","family":"Hoffmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,2,17]]},"reference":[{"key":"1306_CR1","doi-asserted-by":"publisher","first-page":"1713","DOI":"10.2147\/OPTH.S116859","volume":"10","author":"N Tojo","year":"2016","unstructured":"Tojo N, Abe S, Miyakoshi M, Hayashi A (2016) Correlation between short-term and long-term intraocular pressure fluctuation in glaucoma patients. Clin Ophthalmol Auckl NZ 10:1713\u20131717. https:\/\/doi.org\/10.2147\/OPTH.S116859","journal-title":"Clin Ophthalmol Auckl NZ"},{"key":"1306_CR2","doi-asserted-by":"publisher","first-page":"134","DOI":"10.1097\/00061198-200004000-00002","volume":"9","author":"S Asrani","year":"2000","unstructured":"Asrani S, Zeimer R, Wilensky J et al (2000) Large diurnal fluctuations in intraocular pressure are an independent risk factor in patients with glaucoma. J Glaucoma 9:134\u2013142","journal-title":"J Glaucoma"},{"key":"1306_CR3","doi-asserted-by":"publisher","first-page":"997","DOI":"10.1016\/S0161-6420(99)00523-0","volume":"106","author":"B Berge\u00e5","year":"1999","unstructured":"Berge\u00e5 B, Bodin L, Svedbergh B (1999) Impact of intraocular pressure regulation on visual fields in open-angle glaucoma. Ophthalmology 106:997\u20131004. https:\/\/doi.org\/10.1016\/S0161-6420(99)00523-0(discussion 1004\u20131005)","journal-title":"Ophthalmology"},{"key":"1306_CR4","doi-asserted-by":"publisher","first-page":"1123.e3","DOI":"10.1016\/j.ophtha.2007.10.031","volume":"115","author":"J Caprioli","year":"2008","unstructured":"Caprioli J, Coleman AL (2008) Intraocular pressure fluctuation a risk factor for visual field progression at low intraocular pressures in the advanced glaucoma intervention study. Ophthalmology 115:1123.e3\u20131129.e3. https:\/\/doi.org\/10.1016\/j.ophtha.2007.10.031","journal-title":"Ophthalmology"},{"key":"1306_CR5","doi-asserted-by":"publisher","first-page":"1766","DOI":"10.1016\/j.ophtha.2011.01.047","volume":"118","author":"DC Musch","year":"2011","unstructured":"Musch DC, Gillespie BW, Niziol LM et al (2011) Intraocular pressure control and long-term visual field loss in the collaborative initial glaucoma treatment study. Ophthalmology 118:1766\u20131773. https:\/\/doi.org\/10.1016\/j.ophtha.2011.01.047","journal-title":"Ophthalmology"},{"key":"1306_CR6","doi-asserted-by":"publisher","first-page":"1627","DOI":"10.1016\/j.ophtha.2004.02.017","volume":"111","author":"K Nouri-Mahdavi","year":"2004","unstructured":"Nouri-Mahdavi K, Hoffman D, Coleman AL et al (2004) Predictive factors for glaucomatous visual field progression in the advanced glaucoma intervention study. Ophthalmology 111:1627\u20131635. https:\/\/doi.org\/10.1016\/j.ophtha.2004.02.017","journal-title":"Ophthalmology"},{"key":"1306_CR7","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1016\/j.ophtha.2006.07.060","volume":"114","author":"B Bengtsson","year":"2007","unstructured":"Bengtsson B, Leske MC, Hyman L et al (2007) Fluctuation of intraocular pressure and glaucoma progression in the early manifest glaucoma trial. Ophthalmology 114:205\u2013209. https:\/\/doi.org\/10.1016\/j.ophtha.2006.07.060","journal-title":"Ophthalmology"},{"key":"1306_CR8","doi-asserted-by":"publisher","first-page":"934","DOI":"10.1016\/j.ophtha.2007.08.012","volume":"115","author":"FA Medeiros","year":"2008","unstructured":"Medeiros FA, Weinreb RN, Zangwill LM et al (2008) Long-term intraocular pressure fluctuations and risk of conversion from ocular hypertension to glaucoma. Ophthalmology 115:934\u2013940. https:\/\/doi.org\/10.1016\/j.ophtha.2007.08.012","journal-title":"Ophthalmology"},{"key":"1306_CR9","doi-asserted-by":"publisher","first-page":"513","DOI":"10.1007\/s00417-004-1103-8","volume":"243","author":"B Bengtsson","year":"2005","unstructured":"Bengtsson B, Heijl A (2005) Diurnal IOP fluctuation: not an independent risk factor for glaucomatous visual field loss in high-risk ocular hypertension. Graefes Arch Clin Exp Ophthalmol Albrecht Von Graefes Arch F\u00fcr Klin Exp Ophthalmol 243:513\u2013518. https:\/\/doi.org\/10.1007\/s00417-004-1103-8","journal-title":"Graefes Arch Clin Exp Ophthalmol Albrecht Von Graefes Arch F\u00fcr Klin Exp Ophthalmol"},{"key":"1306_CR10","doi-asserted-by":"publisher","first-page":"948","DOI":"10.1038\/sj.eye.6702351","volume":"21","author":"JB Jonas","year":"2007","unstructured":"Jonas JB, Budde WM, Stroux A et al (2007) Diurnal intraocular pressure profiles and progression of chronic open-angle glaucoma. Eye Lond Engl 21:948\u2013951. https:\/\/doi.org\/10.1038\/sj.eye.6702351","journal-title":"Eye Lond Engl"},{"key":"1306_CR11","doi-asserted-by":"publisher","first-page":"1134","DOI":"10.1007\/s00347-012-2671-3","volume":"110","author":"AGM J\u00fcnemann","year":"2013","unstructured":"J\u00fcnemann AGM, Huchzermeyer C, Rejdak R (2013) Medicinal glaucoma therapy. What can we learn from large randomized clinical trials? Ophthalmol Z Dtsch Ophthalmol Ges 110:1134\u20131148. https:\/\/doi.org\/10.1007\/s00347-012-2671-3","journal-title":"Ophthalmol Z Dtsch Ophthalmol Ges"},{"key":"1306_CR12","doi-asserted-by":"publisher","first-page":"1989","DOI":"10.1016\/j.ophtha.2011.03.012","volume":"118","author":"MW Marcus","year":"2011","unstructured":"Marcus MW, de Vries MM, Junoy Montolio FG, Jansonius NM (2011) Myopia as a risk factor for open-angle glaucoma: a systematic review and meta-analysis. Ophthalmology 118:1989\u20131994.e2. https:\/\/doi.org\/10.1016\/j.ophtha.2011.03.012","journal-title":"Ophthalmology"},{"key":"1306_CR13","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1097\/01.ijg.0000151683.04410.f3","volume":"14","author":"B Bengtsson","year":"2005","unstructured":"Bengtsson B, Heijl A (2005) A long-term prospective study of risk factors for glaucomatous visual field loss in patients with ocular hypertension. J Glaucoma 14:135\u2013138","journal-title":"J Glaucoma"},{"key":"1306_CR14","doi-asserted-by":"publisher","first-page":"784","DOI":"10.1038\/eye.2016.86","volume":"30","author":"ML Salvetat","year":"2016","unstructured":"Salvetat ML, Zeppieri M, Tosoni C et al (2016) Baseline factors predicting the risk of conversion from ocular hypertension to primary open-angle glaucoma during a 10-year follow-up. Eye Lond Engl 30:784\u2013795. https:\/\/doi.org\/10.1038\/eye.2016.86","journal-title":"Eye Lond Engl"},{"key":"1306_CR15","doi-asserted-by":"publisher","first-page":"714","DOI":"10.1001\/archopht.120.6.714","volume":"120","author":"MO Gordon","year":"2002","unstructured":"Gordon MO, Beiser JA, Brandt JD et al (2002) The ocular hypertension treatment study: baseline factors that predict the onset of primary open-angle glaucoma. Arch Ophthalmol Chic Ill 1960 120:714\u2013720 (discussion 829\u2013830)","journal-title":"Arch Ophthalmol Chic Ill 1960"},{"key":"1306_CR16","doi-asserted-by":"publisher","first-page":"463","DOI":"10.1016\/j.ajo.2005.10.017","volume":"141","author":"EM Hoffmann","year":"2006","unstructured":"Hoffmann EM, Medeiros FA, Sample PA et al (2006) Relationship between patterns of visual field loss and retinal nerve fiber layer thickness measurements. Am J Ophthalmol 141:463\u2013471. https:\/\/doi.org\/10.1016\/j.ajo.2005.10.017","journal-title":"Am J Ophthalmol"},{"key":"1306_CR17","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1016\/j.ophtha.2006.05.075","volume":"114","author":"S Miglior","year":"2007","unstructured":"Miglior S, Pfeiffer N et al (2007) Predictive factors for open-angle glaucoma among patients with ocular hypertension in the European glaucoma prevention study. Ophthalmology 114:3\u20139. https:\/\/doi.org\/10.1016\/j.ophtha.2006.05.075","journal-title":"Ophthalmology"},{"key":"1306_CR18","doi-asserted-by":"publisher","first-page":"1315","DOI":"10.1136\/bjophthalmol-2013-303980","volume":"98","author":"MC Leidl","year":"2014","unstructured":"Leidl MC, Choi CJ, Syed ZA, Melki SA (2014) Intraocular pressure fluctuation and glaucoma progression: what do we know? Br J Ophthalmol 98:1315\u20131319. https:\/\/doi.org\/10.1136\/bjophthalmol-2013-303980","journal-title":"Br J Ophthalmol"},{"key":"1306_CR19","doi-asserted-by":"publisher","first-page":"1010","DOI":"10.1001\/archopht.125.8.1010","volume":"125","author":"S Hong","year":"1960","unstructured":"Hong S, Seong GJ (1960) Hong YJ (2007) Long-term intraocular pressure fluctuation and progressive visual field deterioration in patients with glaucoma and low intraocular pressures after a triple procedure. Arch Ophthalmol Chic Ill 125:1010\u20131013. https:\/\/doi.org\/10.1001\/archopht.125.8.1010","journal-title":"Arch Ophthalmol Chic Ill"},{"key":"1306_CR20","doi-asserted-by":"publisher","first-page":"347","DOI":"10.1007\/s10792-007-9149-3","volume":"28","author":"V Dayanir","year":"2008","unstructured":"Dayanir V, Aydin S, Okyay P (2008) The association of office intraocular pressure fluctuation in ocular hypertension with frequency doubling technology perimetry abnormality. Int Ophthalmol 28:347\u2013353. https:\/\/doi.org\/10.1007\/s10792-007-9149-3","journal-title":"Int Ophthalmol"},{"key":"1306_CR21","doi-asserted-by":"publisher","first-page":"366","DOI":"10.1016\/j.ophtha.2004.11.030","volume":"112","author":"S Miglior","year":"2005","unstructured":"Miglior S, Zeyen T, Pfeiffer N et al (2005) Results of the European glaucoma prevention study. Ophthalmology 112:366\u2013375. https:\/\/doi.org\/10.1016\/j.ophtha.2004.11.030","journal-title":"Ophthalmology"},{"key":"1306_CR22","doi-asserted-by":"publisher","first-page":"138","DOI":"10.1097\/01.icu.0000193079.55240.18","volume":"17","author":"RK Parrish","year":"2006","unstructured":"Parrish RK (2006) The European glaucoma prevention study and the ocular hypertension treatment study: why do two studies have different results? Curr Opin Ophthalmol 17:138\u2013141. https:\/\/doi.org\/10.1097\/01.icu.0000193079.55240.18","journal-title":"Curr Opin Ophthalmol"},{"key":"1306_CR23","doi-asserted-by":"publisher","first-page":"3178","DOI":"10.1167\/iovs.06-1315","volume":"48","author":"CK-S Leung","year":"2007","unstructured":"Leung CK-S, Cheng ACK, Chong KKL et al (2007) Optic disc measurements in myopia with optical coherence tomography and confocal scanning laser ophthalmoscopy. Invest Ophthalmol Vis Sci 48:3178\u20133183. https:\/\/doi.org\/10.1167\/iovs.06-1315","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"1306_CR24","doi-asserted-by":"publisher","first-page":"715","DOI":"10.1007\/s00347-016-0304-y","volume":"113","author":"EM Hoffmann","year":"2016","unstructured":"Hoffmann EM, Lamparter J (2016) Differentiation of ocular hypertension. Ophthalmol Z Dtsch Ophthalmol Ges 113:715\u2013728. https:\/\/doi.org\/10.1007\/s00347-016-0304-y","journal-title":"Ophthalmol Z Dtsch Ophthalmol Ges"},{"key":"1306_CR25","doi-asserted-by":"publisher","first-page":"230","DOI":"10.1007\/s00347-004-1150-x","volume":"102","author":"N Pfeiffer","year":"2005","unstructured":"Pfeiffer N (2005) Results of the \u201cocular hypertension treatment study\u201d. Ophthalmol Z Dtsch Ophthalmol Ges 102:230\u2013234. https:\/\/doi.org\/10.1007\/s00347-004-1150-x","journal-title":"Ophthalmol Z Dtsch Ophthalmol Ges"},{"key":"1306_CR26","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1016\/j.ophtha.2009.06.061","volume":"117","author":"CK Leung","year":"2010","unstructured":"Leung CK, Ye C, Weinreb RN et al (2010) Retinal nerve fiber layer imaging with spectral-domain optical coherence tomography a study on diagnostic agreement with heidelberg retinal tomograph. Ophthalmology 117:267\u2013274. https:\/\/doi.org\/10.1016\/j.ophtha.2009.06.061","journal-title":"Ophthalmology"},{"key":"1306_CR27","doi-asserted-by":"publisher","first-page":"e455","DOI":"10.1097\/IJG.0000000000000291","volume":"25","author":"L Colombo","year":"2016","unstructured":"Colombo L, Bertuzzi F, Rulli E, Miglior S (2016) Correlations between the individual risk for glaucoma and RNFL and optic disc morphometrical evaluations in ocular hypertensive patients. J Glaucoma 25:e455\u2013462. https:\/\/doi.org\/10.1097\/IJG.0000000000000291","journal-title":"J Glaucoma"},{"key":"1306_CR28","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1016\/j.ajo.2014.10.028","volume":"159","author":"S Miglior","year":"2015","unstructured":"Miglior S, Zeyen T, Hoffmann EM et al (2015) Predictive value of heidelberg retina tomograph parameters for the development of glaucoma in the European glaucoma prevention study. Am J Ophthalmol 159:265\u2013276.e1. https:\/\/doi.org\/10.1016\/j.ajo.2014.10.028","journal-title":"Am J Ophthalmol"}],"container-title":["International Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10792-020-01306-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s10792-020-01306-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10792-020-01306-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,2,18]],"date-time":"2021-02-18T23:06:57Z","timestamp":1613689617000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s10792-020-01306-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,2,17]]},"references-count":28,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2020,6]]}},"alternative-id":["1306"],"URL":"https:\/\/doi.org\/10.1007\/s10792-020-01306-7","relation":{},"ISSN":["0165-5701","1573-2630"],"issn-type":[{"value":"0165-5701","type":"print"},{"value":"1573-2630","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,2,17]]},"assertion":[{"value":"18 September 2019","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 February 2020","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 February 2020","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare that there is no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"The study was supported by a DFG (German research Foundation) grant (HO 3277\/2\u20131). Formal approval from the local ethics committee (Medical Ethical Committee of the State Chamber of Medicine of Rhineland Palatinate in Mainz, Germany) was according to their statute not required for this kind of retrospective study including clinical routine data only.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"The patients gave informed consent about data collection and analysis.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}}]}}